Ayu最新文献

{"title":"Comparative evaluation of a modified endodontic approach using <i>Curcuma longa</i> L. and conventional pulpectomy in primary molars: A randomized clinical trial.","authors":"Putta Sai Sahiti,&nbsp;Rekhalakshmi Kamatham","doi":"10.4103/ayu.AYU_12_20","DOIUrl":"10.4103/ayu.AYU_12_20","url":null,"abstract":"<p><strong>Background: </strong>Turmeric (<i>Curcuma longa</i>) is known for its anti-inflammatory and anti-septic properties.</p><p><strong>Aim: </strong>The aim is to compare a modified endodontic approach using turmeric and conventional Metapex^® pulpectomy in primary molars.</p><p><strong>Materials and methods: </strong>Thirty children, in the age range of 4-9 years, with at least one primary mandibular molar indicated for pulpectomy, were included. Teeth were randomly assigned to turmeric and Metapex^® groups. For those that were assigned to turmeric, after coronal and radicular pulp extirpation, a freshly prepared paste of turmeric powder and methyl cellulose (2:1) with saline was packed in the coronal pulp chamber. In the Metapex^® group, a conventional pulpectomy was performed. Clinical and radiographic success was recorded at 3-, 6-, and 12-month follow-up visits. The data was statistically analyzed using the Chi-square test.</p><p><strong>Results: </strong>There were no clinical and radiographic failures at 3- and 6-month visits in both groups. The 12-month evaluation revealed clinical success rates of 92% (12 out of 13) and 100% (14 out of 14) for turmeric and Metapex^®, respectively, whereas, the radiographic success rates were 85% (12 out of 13) for turmeric and 93% (13 out of 14) for Metapex^®. No statistically significant differences were found between the groups at different follow-ups (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>A modified endodontic approach using turmeric and conventional Metapex^® pulpectomy did not differ significantly in total success after 12 months.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/af/AYU-42-130.PMC10251285.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9619004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Add-on effect of Ayurvedic treatment protocol for diabetic retinopathy: A randomized controlled clinical study.","authors":"V Krishna Kumar,&nbsp;B Vaghela Dharmendra Singh,&nbsp;Rajagopala Manjusha","doi":"10.4103/ayu.AYU_208_19","DOIUrl":"10.4103/ayu.AYU_208_19","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR), the leading cause of visual disability in diabetics, is a significant complication of diabetes mellitus. Currently available conventional treatments for DR have certain limitations, considering which Ayurvedic treatment protocol was designed.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the clinical efficacy of the Ayurvedic treatment protocol for DR.</p><p><strong>Materials and methods: </strong>This was a randomized, controlled, black box design clinical study conducted from April 2016 to September 2017 by the department of Shalakya Tantra of a tertiary academic hospital in Western India. A hundred patients of DR in the age group 30-70 years were randomly divided into two groups by simple random sampling using computer-generated random number tables. In the trial group (<i>n</i> = 70), the preparatory phase included <i>Dipana-Pachana</i> (stomachic and digestant), <i>Koshtha Shodhana</i> (mild therapeutic purgation), and <i>Shiro Virechana</i> (eliminative nasal medication). The treatment phase included <i>Marsha Nasya</i> (nasal medication) and <i>Pratimarsha Nasya</i> (nasal medication of mild dose) with <i>Durvadi Ghrita</i>, <i>Takra Dhara</i> (pouring medicated buttermilk over the scalp) with <i>Siddha Takra</i>, and intake of <i>Rasayana Yoga</i> (treatment duration - 3 months). In the control group (<i>n</i> = 30), patients were kept under conservative treatment and observed during the trial period of 3 months. Patients of both groups continued with their treatment for diabetes and DR if any. Two follow-ups were done at an interval of 15 days. The primary outcomes were objective signs like best-corrected visual acuity (BCVA); ophthalmoscopic signs such as superficial hemorrhages, dot-blot hemorrhages, hard exudates, cotton wool spots, neovascularization disc, neovascularization elsewhere, and fibrovascular proliferation; subjective symptoms such as diminished vision, blurred vision, frequent changes in presbyopia glasses, perception of flashes of light, floaters, and problem for dark adaptation. The secondary outcomes were fasting blood sugar (FBS), postprandial blood sugar (PPBS), urine sugar, serum cholesterol, hemoglobin (Hb), glycosylated HbA1C, liver function test, and renal function test outcomes were assessed before and after the treatment.</p><p><strong>Results: </strong>Ninety participants were included in the analysis of the primary outcome (62 in the trial and 28 in the control group). The trial group provided better results which were statistically significant on dot-blot hemorrhages, superficial hemorrhages, hard exudates, BCVA, FBS, and serum cholesterol. Both the groups provided almost similar effects in PPBS, Hb, HbA1C, and urine sugar which were statistically insignificant. Adverse effects were not reported in any of the patient among either groups.</p><p><strong>Conclusion: </strong>Ayurvedic treatment protocol is safe and effective in DR.</","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/92/AYU-42-118.PMC10251286.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9619005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An observational study on acceptability, palatability, and safety of <i>Ayurveda</i> immunity booster kit for the prevention of COVID-19 in frontline workers in Jaipur, India.","authors":"Sarvesh Kumar Singh,&nbsp;Kshipra Rajoria,&nbsp;Sanjeev Sharma,&nbsp;Pawan Kumar Godatwar,&nbsp;Suman Sharma,&nbsp;Mita Kotecha,&nbsp;Sarvesh Kumar Agrawal,&nbsp;Rajendra Prasad Sharma,&nbsp;Shobhnath Yadav,&nbsp;Ramkishor Joshi","doi":"10.4103/ayu.ayu_16_22","DOIUrl":"10.4103/ayu.ayu_16_22","url":null,"abstract":"<p><strong>Background: </strong>National Institute of Ayurveda, Jaipur, India, had distributed <i>Ayurveda</i> immunity booster kit (AIBK) (prepared at own pharmacy and comprising <i>Chyawanprasha -</i> 300 g, <i>Vyadhi Kshamatva Kwatha</i> - 300 g, and <i>Vyadhi Kshamatva</i> capsule - 30 g) for 15 days among the health-care workers, sanitation workers, and security and police staff engaged in the containment zones for prevention of COVID-19.</p><p><strong>Aim: </strong>The aim of present study was to explore the medication that may be effective in prevention of the COVID -19. Hence, this study was done to assess the compliance of these medicines and their effects in the prevention of COVID-19.</p><p><strong>Methods: </strong>One thousand seven hundred and fourteen frontline workers were provided with the AIBK for 15 days from April 24, 2020, to June 27, 2020. Data of frontline workers who had participated in AIBK and completed the treatment regimen with 2 weeks of follow-up after treatment with complete available data for safety, palatability, efficacy, and compliance were included in the study. Any adverse event needing hospitalization or medication, drug compliance and palatability, and appearance of the symptoms of COVID-19 or testing positive for COVID-19 were the outcome measures.</p><p><strong>Results: </strong>Out of 1714 participants, 1003 participants were found to be eligible for this analysis. The median age of these participants was 39 years (range, 19-70), and males accounted for 90.1% (904 of 1003). A total of 7.5% of participants (75 of 1003) reported having adverse events after taking the study treatment. None of the participants reported any serious adverse effects after the administration of the AIBK. The acceptability of the AIBK was as high as 97.4%. None of the participants reported positive for COVID-19 results or COVID-19 symptoms up to 2 weeks of follow-up after completion of the study treatment.</p><p><strong>Conclusion: </strong>The acceptability of AIBK is good and indicates its role in the prevention of COVID-19-like illness, hence further randomized control trials or cohort studies can be done to assess the mechanism of action and efficacy of AIBK as the preventive strategy in COVID-19.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/26/AYU-42-111.PMC10251284.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9992404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of <i>Haratala Shodhana</i> in the therapeutic efficacy of <i>Rasamanikya</i> along with <i>Guduchi Ghana</i> in the treatment of <i>Ekakushtha</i> (psoriasis): A double-blind randomised clinical trial.","authors":"Dipali Narendrakumar Parekh,&nbsp;Dharmishtha Bopaliya,&nbsp;Dilipkumar Prajapati,&nbsp;Prashant Bedarkar,&nbsp;B J Patgiri","doi":"10.4103/ayu.ayu_292_21","DOIUrl":"10.4103/ayu.ayu_292_21","url":null,"abstract":"<p><strong>Introduction: </strong><i>Rasamanikya</i> (RM) and <i>Guduchi Ghana</i> (GG) are well-known formulations for treating skin disorders in <i>Ayurveda</i>. The drug RM is prepared from <i>Shuddha Haratala</i> (processed orpiment) as a single ingredient. In the present study, RM was prepared from the <i>Haratala</i>, which was <i>Shodhita</i>, with two different media, viz., <i>Kushmanda</i> <i>Swarasa</i> and <i>Churnodaka</i>. In the classics, the preparation of RM is mentioned in the <i>Kushmanda</i> <i>Shodhita</i> <i>Haratala</i>. However, the availability and cost of <i>Kushmanda</i> are the main points of concern in the present era. <i>Shodhana</i> of <i>Haratala</i> by <i>Churnodaka</i> is more cost-effective than <i>Kushmanda</i> <i>Swarasa</i>.</p><p><strong>Aim: </strong>The aim of this study is to evaluate the comparative efficacy of RM prepared by <i>Churnodaka Shodhita Haratala</i> (CSHRM) and RM prepared by <i>Kushmanda Shodhita Haratala</i> (KSHRM) with GG in <i>Ekakustha</i> (psoriasis).</p><p><strong>Materials and methods: </strong>The study was a randomized double-blind study involving 76 patients with <i>Ekakushtha</i> that were randomly divided into two groups. Patients registered in group A (n = 37) were treated with CSHRM with GG (125 mg + 375 mg) and group B (n = 36) with KSHRM with GG (125 mg + 375 mg) for 8 weeks. The Wilcoxon signed rank test and paired t-test were applied to evaluate the effect of therapy in the individual group for subjective criteria like the PASI score, <i>Matsyashakalopamam</i> (looks like the scales of a fish), <i>Rukshata</i> (dryness), <i>Aswedanam</i> (anhydrosis), <i>Daha</i> (burning), <i>Strava</i> (discharge), <i>Unnati</i> (raised patches), <i>Kandu</i> (itching), <i>Mahavastu</i> (broad-based), and <i>Vaivarnya</i> (discoloration), while the comparison of results between the groups for the same was done by applying the Coefficient of Variation (CV).</p><p><strong>Result: </strong>CSHRM with GG showed better results in all signs and symptoms except <i>Matsyaskalopamam</i>, <i>Aswedanam</i>, <i>Strava</i>, <i>Mahavastu</i>, <i>Nindra</i> and DLQI in terms of the coefficient of variation. In both groups, statistically highly significant (P > 0.001) improvement was found in the signs and symptoms of <i>Ekakushtha</i>. However, the difference between the groups was statistically nonsignificant.</p><p><strong>Conclusion: </strong><i>Rasamanikya</i> prepared with both media <i>Shodhita</i> <i>Haratala</i> along with <i>Guduchi Ghana</i> was discovered to be a safe and effective psoriasis treatment.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/c9/AYU-42-76.PMC10158648.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Dhatri Lauha</i> in the management of iron deficiency anemia: A prospective open-label single-arm multi-center trial.","authors":"Narayanam Srikanth,&nbsp;Bhogavalli Chandrasekhara Rao,&nbsp;Babita Yadav,&nbsp;Amit Kumar Rai,&nbsp;Sophia Jameela,&nbsp;Rakesh Kumar Rana,&nbsp;Richa Singhal,&nbsp;Shruti Khanduri,&nbsp;Bhagwan Sahai Sharma,&nbsp;Pratap Makhija","doi":"10.4103/ayu.ayu_379_21","DOIUrl":"10.4103/ayu.ayu_379_21","url":null,"abstract":"<p><strong>Background: </strong>The burden of iron-deficiency anemia (IDA) remains persistently high in India due to the poor tolerability of oral iron supplementation. Therefore, more focus is required to explore traditional medicine for safe and effective options for managing IDA.</p><p><strong>Aim: </strong>To assess the clinical safety and efficacy of <i>Dhatri Lauha</i> in patients with IDA.</p><p><strong>Materials and methods: </strong>An open-label, prospective, single-arm, multi-center trial was conducted at 12 centers with a sample size of 40 participants per study site. Patients with IDA aged 18-60 years with hemoglobin levels in the range of 6-10gm/dl, mean corpuscular volume (MCV) <80 fl, mean corpuscular hemoglobin concentration (MCHC) <34 μg/dl, serum ferritin <30 μg/dl and serum iron <50 μg/dl were included in the study. <i>Dhatri Lauha</i> 500 mg capsule was administered twice daily with lukewarm water after meals for 45 days. The primary outcome measure was the change in hemoglobin (Hb%) level from baseline to day 45. Secondary outcome measures included the change in MCV, MCHC, serum iron and ferritin levels, incidence of adverse events, and change in safety parameters (liver and kidney function tests). The mean (statistical) change in outcome measures from baseline to day 45 was compared using a paired sample t-test.</p><p><strong>Results: </strong>Out of 458 participants enrolled in the study, 400 contributed to the final analysis. A significant difference was observed in the outcome parameters such as Hb%, MCV, MCHC, serum ferritin, and serum iron levels (<i>P</i> < 0.001) after 45 days of treatment. Mean Hb% changed from 8.46 ± 1.14 g/dl at baseline to 9.18 ± 1.61 g/dl on day 45 (<i>P</i> < 0.001). LFT and KFT were within the normal limits after the study period. No participant withdrew from the study due to adverse events.</p><p><strong>Conclusions: </strong><i>Dhatri Lauha</i> is a safe intervention and can be expected to improve hemoglobin levels, red blood cell parameters, and iron stores in patients with IDA. Future RCTs with a larger sample size, standard care as control and a longer follow-up may produce more accurate and reliable results.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/94/AYU-42-69.PMC10158651.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nutritional value and antioxidant activity of <i>Leea macrophylla</i> Roxb. ex Hornem. root and leaf.","authors":"Sarvade Dattatray Durgadas,&nbsp;Acharya Rabinarayan","doi":"10.4103/ayu.AYU_88_19","DOIUrl":"10.4103/ayu.AYU_88_19","url":null,"abstract":"<p><strong>Background: </strong><i>Hanshia dabar</i> or <i>hathkan</i> is one of the folklore plant of Odisha, the botanical source of which is <i>Leea macrophylla</i> Roxb. ex Hornem., family Vitaceae. Its root and leaves are eaten as vegetables, and used for <i>Rasayana</i> purpose (tonic and alterative properties).</p><p><strong>Aim: </strong>The aim is to assess the nutritive value and antioxidant potential of the root and leaves of <i>L. macrophylla</i> with compound leaf.</p><p><strong>Materials and methods: </strong>Nutritional parameters such as energy value, carbohydrate, protein, true protein, fat, mineral contents, and Vitamin A, Vitamin C of the root and leaves of the plant were evaluated with standard procedures. The <i>in vitro</i> antioxidant properties of the root and leaf of <i>L. macrophylla</i> were screened through 1,1diphenyl2picrylhydrazyl (DPPH) assay, the ferric reducing antioxidant power (FRAP) assay, and phosphomolybdenum assay.</p><p><strong>Results: </strong>Root is having higher energy value (391.87 Kcal/100 g) as compared to leaf (353.62 Kcal/100 g). <i>L. macrophylla</i> root and leaf showed the presence of carbohydrates (30.65% and 21.72%), protein (8.78% and 9.37%), true protein (6.85% and 7.23%), fat (0.77% and 1.89%), iron (723.80 ppm and 285.07 ppm), zinc (26.51 ppm and 13.75 ppm), manganese (44.88 ppm and 35.00 ppm), phosphorous (0.07 ppm and 0.03 ppm), calcium (7806.90 ppm and 3862.80 ppm), Vitamin A (3.63 mg/g and 2.47 mg/g), and Vitamin C (8.49 mg/g and 6.7 mg/g), respectively. Percentage scavenging of DPPH radical was found to rise with an increase in concentration. IC50 values of root and leaf, by DPPH assay, were 66.46 and 110.68 μg/ml, respectively. In the FRAP assay, the antioxidant activity of the methanolic extract of leaf (507.06 μmol/l) was found to be more than root (455.93 μmol/l). The total antioxidant capacity of root and leaf were 20.15 and 17.90 mg, equivalent to ascorbic acid on a dry weight basis, respectively.</p><p><strong>Conclusion: </strong>Root and leaf of <i>L. macrophylla</i> has the highest energy value, contains carbohydrate, protein, fat, iron, zinc, manganese, phosphorous, calcium, Vitamin A, and Vitamin C, and possesses antioxidant capacity.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6a/de/AYU-42-87.PMC10158650.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine and technology: A need for the health-care system.","authors":"Mandip Goyal","doi":"10.4103/ayu.ayu_5_23","DOIUrl":"10.4103/ayu.ayu_5_23","url":null,"abstract":"Human civilization has witnessed numerous changes to evolve itself since its inception. Every revolution that was taken either catastrophically or by gradual procedure by our ancestors themselves had evolved the generation for good, be it the straight posture of homo‐ sapiens, its colonization habits, or the human civilization itself. As every coin has both sides, despite many pitfalls, humans kept evolving themselves in pursuit of a more congenial future.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/64/AYU-42-67.PMC10158653.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9486168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognosy, phytochemistry, and molecular studies of an important medicinal herb <i>Achillea millefolium</i> L.","authors":"Prasanna Kumar,&nbsp;R Shruthi,&nbsp;I Bindu,&nbsp;P Raghavendra","doi":"10.4103/ayu.ayu_401_21","DOIUrl":"10.4103/ayu.ayu_401_21","url":null,"abstract":"<p><strong>Background: </strong><i>Achillea</i> <i>millefolium</i> L. is traditionally important medicinal herb used for the treatment of various ailments from the centuries. Recent studies showed its biological activities on hay fever, hepato-biliary disorders, and as appetite enhancing drug. It is also reported to be used for the treatments of skin inflammations, wounds, cuts, and abrasions.</p><p><strong>Aim: </strong>To investigate preliminary pharmacognostical, phytochemical, and molecular parameters of aerial parts of the drug.</p><p><strong>Materials and methods: </strong><i>A. millefolium</i> was identified and collected from the Himalaya region. The material is properly dried, macro-and microscopic evaluation, phytochemical and molecular studies as per the standard quality control and WHO guidelines.</p><p><strong>Results: </strong>The leaves are pinnately lobed, inflorescence compound corymbose. Nonglandular trichomes are uni-seriate, multicellular, and smooth walled; glandular trichomes are bicellular, present throughout the aerial parts. The endodermis is evident in the stem and leaf mesophyll is equifacial. The partial genome sequence analysis showed similarity toward studied species, which can clearly distinguish it from other species of the genus <i>Achillea</i>. The best chromatographic separation was observed with ascentis express C18, 2.7 μm, 100 mm × 4.6 mm. The flavonoids and phenolic acids have shown maximum absorbance at 330 nm. The system suitability parameters such as theoretical plate, tailing factor, and resolution met the acceptance criteria with United States pharmacopeia (USP).</p><p><strong>Conclusion: </strong>The findings of this study will be helpful for the precise identification of the raw drug of <i>A. millefolium</i> from its closely allied species.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/8b/AYU-42-93.PMC10158652.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of <i>Punarnavadi Mandura</i> for haematinic activity against mercuric chloride-induced anemia in albino rats.","authors":"V K Kori,&nbsp;B Ravishankar,&nbsp;K S Patel","doi":"10.4103/ayu.AYU_294_20","DOIUrl":"10.4103/ayu.AYU_294_20","url":null,"abstract":"<p><strong>Background: </strong><i>Punarnavadi</i> <i>Mandura</i>, a compound Ayurvedic formulation, is one of the most commonly used medicine in the treatment of anemia (<i>Pandu</i>) in Ayurveda. The safety profile of this formulation is well established; however, no pharmacological study has been reported to provide the scientific basis for its use in the treatment of anemia.</p><p><strong>Aim: </strong>To evaluate the hematinic effect of <i>Punarnavadi</i> <i>Mandura</i> against mercuric chloride-induced anemia in albino rats.</p><p><strong>Materials and methods: </strong>The test drug (<i>Punarnavadi</i> <i>Mandura</i>) was suspended in distilled water and administered orally in a dose of 450 mg/kg for 30 days in rats. Anemia was induced by simultaneous administration of mercuric chloride (9 mg/kg) for 30 consecutive days. Body weight was noted for each animals. At the end, haematological parameters, anaemia markers like serum iron, ferritin, and total iron binding capacity (TIBC), as well as relative weight of organs and histopathology investigation, were examined.</p><p><strong>Results: </strong>Exposure of mercuric chloride to rats for 30 days resulted in a significant decrease of body weight, an increase in the weight of the liver and kidney and a decrease in hemoglobin content. It also decreased serum ferritin to a significant extent and increased serum TIBC. Histopathology of the liver shows macro fatty changes, vacuolization, marked necrosis, and severe degenerative changes, while the kidney shows cell infiltration. All these changes were significantly attenuated by the administration of <i>Punarnavadi</i> <i>Mandura</i>.</p><p><strong>Conclusion: </strong>The present data indicate that <i>Punarnavadi</i> <i>Mandura</i> has possessing marked cytoprotective activity, significantly attenuated the HgCl₂-induced adverse changes on red blood cell related parameters, and showing hematinic activity in albino rats.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/43/AYU-42-103.PMC10158649.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9432580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between <i>Vedic</i> personality traits (<i>Sattva, Rajas</i>, and <i>Tamas</i>) with life satisfaction and perceived stress in healthy university students: A cross-sectional study.","authors":"Shubham Sharma,&nbsp;Praerna Hemant Bhargav,&nbsp;Pooja Singh,&nbsp;Hemant Bhargav,&nbsp;Shivarama Varambally","doi":"10.4103/ayu.ayu_98_21","DOIUrl":"10.4103/ayu.ayu_98_21","url":null,"abstract":"<p><strong>Introduction: </strong><i>Trigunas</i> are three basic mental attributes of a personality according to Indian <i>Vedic</i> literature that explains the relationship between mental attributes and human behavior. The three attributes are <i>Tamas</i> (tendency toward lethargy and rigidity), <i>Rajas</i> (tendency toward ambition and activity) and <i>Sattva</i> (tendency toward selfless service), respectively. Satisfaction with life and perceived stress are the important determinants of one's quality of life.</p><p><strong>Aim: </strong>A cross-sectional study assessed the relationship between <i>Trigunas</i>, life satisfaction and perceived stress.</p><p><strong>Materials and methods: </strong>The study recruited 121 willing healthy university students (75 females) with general health questionnaire scores ≤3. All participants were assessed using standardized psychometric tools.</p><p><strong>Results: </strong>Spearman two-tailed correlation test revealed <i>Sattva</i> to have positive correlation with life satisfaction (<i>r</i> = 0.503) and negative correlation with perceived stress (<i>r</i> = -0.302) and other two <i>Gunas</i> (<i>Tamas</i>: <i>R</i> = -0.77; <i>Rajas</i>: <i>R</i> = -0.75), respectively. On the other hand, both <i>Rajas</i> and <i>Tamas</i> correlated positively with perceived stress (<i>Raja</i>s: <i>R</i> = 0.183; <i>Tamas</i>: <i>R</i> = 0.321) and negatively with life satisfaction (<i>Rajas</i>: <i>R</i> = -0.40; <i>Tamas</i>: <i>R</i> = -0.36).</p><p><strong>Conclusion: </strong>This cross-sectional study on university students in India suggests an association of <i>Vedic</i> personality traits (<i>Sattva, Rajas</i> and <i>Tamas Gunas</i>) with life satisfaction, and perceived stress.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/ab/AYU-42-39.PMC9893901.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}