Haratala Shodhana在Rasamanikya和Guduchi Ghana治疗Ekakushtha(银屑病)疗效中的作用:一项双盲随机临床试验。

Ayu Pub Date : 2021-04-01 Epub Date: 2023-03-16 DOI:10.4103/ayu.ayu_292_21
Dipali Narendrakumar Parekh, Dharmishtha Bopaliya, Dilipkumar Prajapati, Prashant Bedarkar, B J Patgiri
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引用次数: 0

摘要

简介:Rasamanikya(RM)和Guduchi Ghana(GG)是阿育吠陀中治疗皮肤疾病的著名配方。药物RM是由Shuddha Haratala(加工雌黄)作为单一成分制备的。在本研究中,RM是用两种不同的介质,即Kushmanda Swarasa和Churnodaka,从Shodhita的Haratala制备的。在经典中,Kushmanda Shodhita Haratala中提到了RM的准备。然而,Kushmanda的可用性和成本是当今时代关注的主要问题。Churnodaka的Shodhana of Haratala比Kushmanda Swarasa更具成本效益。目的:本研究的目的是评估Churnodaka-Shodhita Haratala(CSHRM)和Kushman达·Shodhita哈拉塔拉(KSHRM)制备的RM与GG在Ekakustha(银屑病)中的比较疗效。材料和方法:该研究是一项随机双盲研究,涉及76名Ekakushtha患者将其随机分为两组。A组(n=37)的患者接受CSHRM加GG(125 mg+375 mg)治疗,B组(n=36)接受KSHRM加GG(125mg+375 mg.)治疗8周。根据主观标准,如PASI评分、Matsyashakalopamam(看起来像鱼的鳞片)、Rukshata(干燥)、Aswedanam(脱水)、Daha(烧伤)、Strava(出院)、Unnati(凸起的斑块)、Kandu(瘙痒)、Mahavastu(基础广泛)和Vaivarnya(变色),应用Wilcoxon符号秩检验和配对t检验来评估个体组的治疗效果,结果:CSHRM和GG在除Matsyaskalopam、Aswedanam、Strava、Mahavastu、Nindra和DLQI外的所有体征和症状方面均表现出较好的变异系数。在两组中,Ekakushtha的体征和症状均有统计学意义的显著改善(P>0.001)。然而,两组之间的差异在统计学上并不显著。结论:用Shodhita Haratala和Guduchi Ghana两种介质制备Rasamanikya是一种安全有效的银屑病治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Role of <i>Haratala Shodhana</i> in the therapeutic efficacy of <i>Rasamanikya</i> along with <i>Guduchi Ghana</i> in the treatment of <i>Ekakushtha</i> (psoriasis): A double-blind randomised clinical trial.

Role of <i>Haratala Shodhana</i> in the therapeutic efficacy of <i>Rasamanikya</i> along with <i>Guduchi Ghana</i> in the treatment of <i>Ekakushtha</i> (psoriasis): A double-blind randomised clinical trial.

Role of <i>Haratala Shodhana</i> in the therapeutic efficacy of <i>Rasamanikya</i> along with <i>Guduchi Ghana</i> in the treatment of <i>Ekakushtha</i> (psoriasis): A double-blind randomised clinical trial.

Role of Haratala Shodhana in the therapeutic efficacy of Rasamanikya along with Guduchi Ghana in the treatment of Ekakushtha (psoriasis): A double-blind randomised clinical trial.

Introduction: Rasamanikya (RM) and Guduchi Ghana (GG) are well-known formulations for treating skin disorders in Ayurveda. The drug RM is prepared from Shuddha Haratala (processed orpiment) as a single ingredient. In the present study, RM was prepared from the Haratala, which was Shodhita, with two different media, viz., Kushmanda Swarasa and Churnodaka. In the classics, the preparation of RM is mentioned in the Kushmanda Shodhita Haratala. However, the availability and cost of Kushmanda are the main points of concern in the present era. Shodhana of Haratala by Churnodaka is more cost-effective than Kushmanda Swarasa.

Aim: The aim of this study is to evaluate the comparative efficacy of RM prepared by Churnodaka Shodhita Haratala (CSHRM) and RM prepared by Kushmanda Shodhita Haratala (KSHRM) with GG in Ekakustha (psoriasis).

Materials and methods: The study was a randomized double-blind study involving 76 patients with Ekakushtha that were randomly divided into two groups. Patients registered in group A (n = 37) were treated with CSHRM with GG (125 mg + 375 mg) and group B (n = 36) with KSHRM with GG (125 mg + 375 mg) for 8 weeks. The Wilcoxon signed rank test and paired t-test were applied to evaluate the effect of therapy in the individual group for subjective criteria like the PASI score, Matsyashakalopamam (looks like the scales of a fish), Rukshata (dryness), Aswedanam (anhydrosis), Daha (burning), Strava (discharge), Unnati (raised patches), Kandu (itching), Mahavastu (broad-based), and Vaivarnya (discoloration), while the comparison of results between the groups for the same was done by applying the Coefficient of Variation (CV).

Result: CSHRM with GG showed better results in all signs and symptoms except Matsyaskalopamam, Aswedanam, Strava, Mahavastu, Nindra and DLQI in terms of the coefficient of variation. In both groups, statistically highly significant (P > 0.001) improvement was found in the signs and symptoms of Ekakushtha. However, the difference between the groups was statistically nonsignificant.

Conclusion: Rasamanikya prepared with both media Shodhita Haratala along with Guduchi Ghana was discovered to be a safe and effective psoriasis treatment.

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