{"title":"Haratala Shodhana在Rasamanikya和Guduchi Ghana治疗Ekakushtha(银屑病)疗效中的作用:一项双盲随机临床试验。","authors":"Dipali Narendrakumar Parekh, Dharmishtha Bopaliya, Dilipkumar Prajapati, Prashant Bedarkar, B J Patgiri","doi":"10.4103/ayu.ayu_292_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong><i>Rasamanikya</i> (RM) and <i>Guduchi Ghana</i> (GG) are well-known formulations for treating skin disorders in <i>Ayurveda</i>. The drug RM is prepared from <i>Shuddha Haratala</i> (processed orpiment) as a single ingredient. In the present study, RM was prepared from the <i>Haratala</i>, which was <i>Shodhita</i>, with two different media, viz., <i>Kushmanda</i> <i>Swarasa</i> and <i>Churnodaka</i>. In the classics, the preparation of RM is mentioned in the <i>Kushmanda</i> <i>Shodhita</i> <i>Haratala</i>. However, the availability and cost of <i>Kushmanda</i> are the main points of concern in the present era. <i>Shodhana</i> of <i>Haratala</i> by <i>Churnodaka</i> is more cost-effective than <i>Kushmanda</i> <i>Swarasa</i>.</p><p><strong>Aim: </strong>The aim of this study is to evaluate the comparative efficacy of RM prepared by <i>Churnodaka Shodhita Haratala</i> (CSHRM) and RM prepared by <i>Kushmanda Shodhita Haratala</i> (KSHRM) with GG in <i>Ekakustha</i> (psoriasis).</p><p><strong>Materials and methods: </strong>The study was a randomized double-blind study involving 76 patients with <i>Ekakushtha</i> that were randomly divided into two groups. Patients registered in group A (n = 37) were treated with CSHRM with GG (125 mg + 375 mg) and group B (n = 36) with KSHRM with GG (125 mg + 375 mg) for 8 weeks. The Wilcoxon signed rank test and paired t-test were applied to evaluate the effect of therapy in the individual group for subjective criteria like the PASI score, <i>Matsyashakalopamam</i> (looks like the scales of a fish), <i>Rukshata</i> (dryness), <i>Aswedanam</i> (anhydrosis), <i>Daha</i> (burning), <i>Strava</i> (discharge), <i>Unnati</i> (raised patches), <i>Kandu</i> (itching), <i>Mahavastu</i> (broad-based), and <i>Vaivarnya</i> (discoloration), while the comparison of results between the groups for the same was done by applying the Coefficient of Variation (CV).</p><p><strong>Result: </strong>CSHRM with GG showed better results in all signs and symptoms except <i>Matsyaskalopamam</i>, <i>Aswedanam</i>, <i>Strava</i>, <i>Mahavastu</i>, <i>Nindra</i> and DLQI in terms of the coefficient of variation. In both groups, statistically highly significant (P > 0.001) improvement was found in the signs and symptoms of <i>Ekakushtha</i>. However, the difference between the groups was statistically nonsignificant.</p><p><strong>Conclusion: </strong><i>Rasamanikya</i> prepared with both media <i>Shodhita</i> <i>Haratala</i> along with <i>Guduchi Ghana</i> was discovered to be a safe and effective psoriasis treatment.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/c9/AYU-42-76.PMC10158648.pdf","citationCount":"0","resultStr":"{\"title\":\"Role of <i>Haratala Shodhana</i> in the therapeutic efficacy of <i>Rasamanikya</i> along with <i>Guduchi Ghana</i> in the treatment of <i>Ekakushtha</i> (psoriasis): A double-blind randomised clinical trial.\",\"authors\":\"Dipali Narendrakumar Parekh, Dharmishtha Bopaliya, Dilipkumar Prajapati, Prashant Bedarkar, B J Patgiri\",\"doi\":\"10.4103/ayu.ayu_292_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong><i>Rasamanikya</i> (RM) and <i>Guduchi Ghana</i> (GG) are well-known formulations for treating skin disorders in <i>Ayurveda</i>. The drug RM is prepared from <i>Shuddha Haratala</i> (processed orpiment) as a single ingredient. In the present study, RM was prepared from the <i>Haratala</i>, which was <i>Shodhita</i>, with two different media, viz., <i>Kushmanda</i> <i>Swarasa</i> and <i>Churnodaka</i>. In the classics, the preparation of RM is mentioned in the <i>Kushmanda</i> <i>Shodhita</i> <i>Haratala</i>. However, the availability and cost of <i>Kushmanda</i> are the main points of concern in the present era. <i>Shodhana</i> of <i>Haratala</i> by <i>Churnodaka</i> is more cost-effective than <i>Kushmanda</i> <i>Swarasa</i>.</p><p><strong>Aim: </strong>The aim of this study is to evaluate the comparative efficacy of RM prepared by <i>Churnodaka Shodhita Haratala</i> (CSHRM) and RM prepared by <i>Kushmanda Shodhita Haratala</i> (KSHRM) with GG in <i>Ekakustha</i> (psoriasis).</p><p><strong>Materials and methods: </strong>The study was a randomized double-blind study involving 76 patients with <i>Ekakushtha</i> that were randomly divided into two groups. Patients registered in group A (n = 37) were treated with CSHRM with GG (125 mg + 375 mg) and group B (n = 36) with KSHRM with GG (125 mg + 375 mg) for 8 weeks. The Wilcoxon signed rank test and paired t-test were applied to evaluate the effect of therapy in the individual group for subjective criteria like the PASI score, <i>Matsyashakalopamam</i> (looks like the scales of a fish), <i>Rukshata</i> (dryness), <i>Aswedanam</i> (anhydrosis), <i>Daha</i> (burning), <i>Strava</i> (discharge), <i>Unnati</i> (raised patches), <i>Kandu</i> (itching), <i>Mahavastu</i> (broad-based), and <i>Vaivarnya</i> (discoloration), while the comparison of results between the groups for the same was done by applying the Coefficient of Variation (CV).</p><p><strong>Result: </strong>CSHRM with GG showed better results in all signs and symptoms except <i>Matsyaskalopamam</i>, <i>Aswedanam</i>, <i>Strava</i>, <i>Mahavastu</i>, <i>Nindra</i> and DLQI in terms of the coefficient of variation. In both groups, statistically highly significant (P > 0.001) improvement was found in the signs and symptoms of <i>Ekakushtha</i>. However, the difference between the groups was statistically nonsignificant.</p><p><strong>Conclusion: </strong><i>Rasamanikya</i> prepared with both media <i>Shodhita</i> <i>Haratala</i> along with <i>Guduchi Ghana</i> was discovered to be a safe and effective psoriasis treatment.</p>\",\"PeriodicalId\":8720,\"journal\":{\"name\":\"Ayu\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/c9/AYU-42-76.PMC10158648.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ayu\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ayu.ayu_292_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/3/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.ayu_292_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/16 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Role of Haratala Shodhana in the therapeutic efficacy of Rasamanikya along with Guduchi Ghana in the treatment of Ekakushtha (psoriasis): A double-blind randomised clinical trial.
Introduction: Rasamanikya (RM) and Guduchi Ghana (GG) are well-known formulations for treating skin disorders in Ayurveda. The drug RM is prepared from Shuddha Haratala (processed orpiment) as a single ingredient. In the present study, RM was prepared from the Haratala, which was Shodhita, with two different media, viz., KushmandaSwarasa and Churnodaka. In the classics, the preparation of RM is mentioned in the KushmandaShodhitaHaratala. However, the availability and cost of Kushmanda are the main points of concern in the present era. Shodhana of Haratala by Churnodaka is more cost-effective than KushmandaSwarasa.
Aim: The aim of this study is to evaluate the comparative efficacy of RM prepared by Churnodaka Shodhita Haratala (CSHRM) and RM prepared by Kushmanda Shodhita Haratala (KSHRM) with GG in Ekakustha (psoriasis).
Materials and methods: The study was a randomized double-blind study involving 76 patients with Ekakushtha that were randomly divided into two groups. Patients registered in group A (n = 37) were treated with CSHRM with GG (125 mg + 375 mg) and group B (n = 36) with KSHRM with GG (125 mg + 375 mg) for 8 weeks. The Wilcoxon signed rank test and paired t-test were applied to evaluate the effect of therapy in the individual group for subjective criteria like the PASI score, Matsyashakalopamam (looks like the scales of a fish), Rukshata (dryness), Aswedanam (anhydrosis), Daha (burning), Strava (discharge), Unnati (raised patches), Kandu (itching), Mahavastu (broad-based), and Vaivarnya (discoloration), while the comparison of results between the groups for the same was done by applying the Coefficient of Variation (CV).
Result: CSHRM with GG showed better results in all signs and symptoms except Matsyaskalopamam, Aswedanam, Strava, Mahavastu, Nindra and DLQI in terms of the coefficient of variation. In both groups, statistically highly significant (P > 0.001) improvement was found in the signs and symptoms of Ekakushtha. However, the difference between the groups was statistically nonsignificant.
Conclusion: Rasamanikya prepared with both media ShodhitaHaratala along with Guduchi Ghana was discovered to be a safe and effective psoriasis treatment.