Pharmacognosy, phytochemistry, and molecular studies of an important medicinal herb Achillea millefolium L.

Ayu Pub Date : 2021-04-01 Epub Date: 2023-03-16 DOI:10.4103/ayu.ayu_401_21
Prasanna Kumar, R Shruthi, I Bindu, P Raghavendra
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Abstract

Background: Achillea millefolium L. is traditionally important medicinal herb used for the treatment of various ailments from the centuries. Recent studies showed its biological activities on hay fever, hepato-biliary disorders, and as appetite enhancing drug. It is also reported to be used for the treatments of skin inflammations, wounds, cuts, and abrasions.

Aim: To investigate preliminary pharmacognostical, phytochemical, and molecular parameters of aerial parts of the drug.

Materials and methods: A. millefolium was identified and collected from the Himalaya region. The material is properly dried, macro-and microscopic evaluation, phytochemical and molecular studies as per the standard quality control and WHO guidelines.

Results: The leaves are pinnately lobed, inflorescence compound corymbose. Nonglandular trichomes are uni-seriate, multicellular, and smooth walled; glandular trichomes are bicellular, present throughout the aerial parts. The endodermis is evident in the stem and leaf mesophyll is equifacial. The partial genome sequence analysis showed similarity toward studied species, which can clearly distinguish it from other species of the genus Achillea. The best chromatographic separation was observed with ascentis express C18, 2.7 μm, 100 mm × 4.6 mm. The flavonoids and phenolic acids have shown maximum absorbance at 330 nm. The system suitability parameters such as theoretical plate, tailing factor, and resolution met the acceptance criteria with United States pharmacopeia (USP).

Conclusion: The findings of this study will be helpful for the precise identification of the raw drug of A. millefolium from its closely allied species.

Abstract Image

Abstract Image

Abstract Image

一种重要中草药千叶Achillea millefolium L.的生药学、植物化学和分子研究。
背景:百年来,山艾是治疗各种疾病的传统重要草药。最近的研究表明,它对花粉热、肝胆疾病和食欲增强药物具有生物学活性。据报道,它还可用于治疗皮肤炎症、伤口、割伤和擦伤。目的:初步研究该药地上部分的生药学、植物化学和分子参数。材料和方法:从喜马拉雅地区鉴定和采集了千层草。根据标准质量控制和世界卫生组织指南,对材料进行适当干燥、宏观和微观评估、植物化学和分子研究。结果:叶羽状浅裂,花序复合伞房状。非陆地毛状体是单序列的,多细胞的,和光滑的壁;腺毛是双细胞的,存在于整个地上部分。内皮层在茎部明显,叶肉等面。部分基因组序列分析显示,与所研究的物种相似,可以清楚地将其与Achillea属的其他物种区分开来。用ascentis express C18,2.7μm,100 mm×4.6 mm进行了最佳色谱分离。黄酮类化合物和酚酸在330 nm处显示出最大吸光度。系统适用性参数,如理论板、拖尾因子和分辨率,符合美国药典(USP)的验收标准。结论:本研究结果将有助于从其近缘种中准确鉴定千层草的原料药。
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Ayu
Ayu
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