Ayu最新文献

{"title":"Efficacy of <i>Vamana Karma</i> (therapeutic emesis) followed by <i>Darvyadi Kwatha</i> (herbal decoction) in the management of prediabetes (<i>Prameha</i>) - A single-arm clinical trial.","authors":"Uttamram Yadav,&nbsp;Santosh Kumar Bhatted","doi":"10.4103/ayu.ayu_417_20","DOIUrl":"10.4103/ayu.ayu_417_20","url":null,"abstract":"<p><strong>Background: </strong>Prediabetes is an alarming condition to control and prevent from developing diabetes mellitus which occurs due to the change in lifestyle and food habits. Timely untreated prediabetes turn into type-2 diabetes mellitus within a year and systemic complications such as retinopathy, nephropathy, and neuropathy could occur and in later stage multi system damage could take place.</p><p><strong>Aims: </strong>The ai of this study is to evaluate the efficacy of <i>Vamana Karma</i> (therapeutic emesis) with <i>Ikshuvaku Yoga</i> and followed by oral administration of <i>Darvyadi Kwatha</i> (herbal decoction) in the management of prediabetes.</p><p><strong>Materials and methods: </strong>After approval of IEC and registration under clinical trial registry of India, 20 patients suffering from prediabetes were registered in the trial. Diagnosis criteria were hemoglobin A1c (HBA1c), fasting blood sugar (FBS) and postprandial blood sugar (PPBS), and assessment criteria includes HBA1c, FBS, PPBS, along with improvement in <i>Agnibala</i> (strength of digestion and metabolism), <i>Dehabala</i> (physical strength) and <i>Satvabala</i> (mental strength), relief sign and symptom of prediabetes (<i>Prameha</i>), and improvement in quality of life (SF-36 Score). Classical <i>Vamana Karma</i> followed by oral administration of <i>Darvyadi Kwatha</i> was done. Total duration of treatment was 45 days and last follow-up was done on the 120^th day. Student's <i>t</i>- test was used for the analysis of parametric data.</p><p><strong>Results: </strong>After the treatment were observed that there is improvement in subjective as well as in objective parameters. Statistically highly significant result was observed in HBA1c (BT [day 0] Mean score 6.25 and AT [day 120] 5.63 [<i>P</i> < 0.001]), FBS (BT [day 0] mean score 120.05 and AT [day 120] 93.31 [<i>P</i> < 0.001]) and PPBS (BT [day 0] mean score 165.26 and AT [day 120] 112.84 [<i>P</i> < 0.001]), sign and symptoms of <i>Prameha, Dehabala, Agnibala, Satvabala</i>, and quality of life (SF-36 Score).</p><p><strong>Conclusion: </strong>The present clinical study concludes that therapeutic emesis (bio purification) followed by <i>Darvyadi Kwatha</i> as internal medicine shows significant result in treating prediabetes (<i>Prameha</i>) safely and effectively also control and prevent developing diabetes mellitus. None of the patient converted to diabetes mellitus on the day 120.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/45/AYU-42-30.PMC9893903.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of external application of oil and gel dosage forms of <i>Aragvadhadi</i> formulation in combination with <i>Rasayana Churna</i> in the management of <i>Shwitra</i> (vitiligo) - An open-labeled comparative clinical trial.","authors":"Sarika Makwana,&nbsp;Dipali Parekh,&nbsp;Prashant Bedarkar,&nbsp;Biswajyoti Patgiri","doi":"10.4103/ayu.AYU_323_20","DOIUrl":"10.4103/ayu.AYU_323_20","url":null,"abstract":"<p><strong>Introduction: </strong><i>Aragvadhadi Taila</i> (ART) is one of the herbomineral formulations mentioned in Chakradatta indicated in <i>Shwitra</i> (vitiligo). Modification of <i>Taila</i> form into gel form reduces the risk of contamination in view of arsenical contents (<i>Manahshila</i>, <i>Haratala</i>) assures precise dose administration at desired site (by avoiding spreading). The gel is a comparatively acceptable dosage form than that of medicated oil.</p><p><strong>Aim: </strong>The aim of the study is to evaluate the comparative efficacy of <i>Aragvadhadi</i> formulation in <i>Taila</i> (ART: <i>Aragvadhadi Taila</i>) and gel (ARG: <i>Aragvadhadi</i> gel) dosage forms with the internal administration of <i>Rasayana Churna</i> in the management of <i>Shwitra</i>.</p><p><strong>Materials and methods: </strong>The study was a randomized open labeled, involving 66 patients of <i>Shwitra</i> that were randomly divided into two groups. Patients registered in group A (<i>n</i> = 34) were treated with local applications of ART and group B (<i>n</i> = 32) with ARG for 2 months. <i>Rasayana Churna</i> (3 g), along with the equal quantity of honey and <i>Ghrita</i> was given twice a day after the meal in both groups. Wilcoxon signed-rank test was applied to evaluate the effect of therapy in the individual group for subjective criteria like vitiligo area scoring index score, size and number of patches, <i>Rukshata</i> (dryness), <i>Saparidaha</i> (burning sensation), <i>Bahalatva</i> (thickening), <i>Kandu</i> (itching) while the comparison of results between the groups for the same by applying Coefficient of Variation (CV).</p><p><strong>Results: </strong>Group B showed better and consistent results in all signs and symptoms except <i>Rukshata, Saparidaha</i> in terms of Coefficient of Variation. In both the groups, statistically highly significant improvement was found in signs and symptoms of <i>Shwitra</i> such as <i>Saparidaha, Kandu</i>, size of patches and number of patches; however, the difference between the groups was statistically insignificant.</p><p><strong>Conclusion: </strong>Both the forms (ART, ARG) of <i>Aragvadhadi</i> formulation along with <i>Rasayana Churna</i> were found as a safe and effective treatment in vitiligo with significant pigment regeneration capacity as topical use for application over 2 months.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/78/AYU-42-19.PMC9893897.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9230752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacodynamic appraisal of wound-healing herbs of <i>Sushruta Samhita</i>.","authors":"Vishal Kumar,&nbsp;Tanuja Manoj Nesari,&nbsp;Shivani Ghildiyal,&nbsp;Rahul Sherkhane","doi":"10.4103/ayu.AYU_34_20","DOIUrl":"10.4103/ayu.AYU_34_20","url":null,"abstract":"Background: In Sushruta Samhita, various medicinal plants as single and compound formulations having Vrana-Shodhana (wound cleansing) and Vrana-Ropana (wound healing) potential are enumerated. There are no published data available on these wound-healing medicinal plants of Sushruta Samhita. The effectivee management of wound is necessary in the immunocompromised and chronic wounds patients as they take more time to heal. Aim: To review and systematically analyze wound-healing medicinal plants and their modus-operandi on the basis of pharmacodynamics attributes, i.e., Rasa (taste), Veerya (potency), and Vipaka (biotransformation) in the various stages of healing. Materials and methods: Review of Sushruta Samhita was done to gather wound-healing medicinal plants; pharmacodynamics attributes were gatherd from various Nighantus to understand their role in wound healing. The contemporary information about wound-healing mechanism was gathered from PubMed to interpitate the rational use of plants in the various stages of wound healing. Results: The study suggests that 43 medicinal plants have Vrana-Shodhana activity, 48 have Vrana-Ropana and 62 have both Vrana-Shodhana and Vrana-Ropana potential. Medicinal plants with Vrana-Shodhana category are having predominance of Katu (pungent), Tikta (bitter) and Kashaya (astriengent) Rasa. Plants under Vrana-Ropana are having Madhura, Kashaya Rasa (sweet taste), Madhura Vipaka (sweet biotransform) and Sheeta Veerya (cold potency). Conclusion: Plants having Tikta, Kashaya Rasa, Katu Vipaka, and Sheeta Veerya may be useful in the inflammatory stage, plants having Madhura, Kashaya Rasa and Sheeta Veerya may be useful in the prolifiratory stage and plants having Madhura Rasa, Sheeta Veerya, and Madhura Vipaka may be useful in the remodeling stage. The present review will help to give the directions to the researchers for the development of effective wound-healing medicines for wounds.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/77/AYU-42-1.PMC9893898.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9230750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifertility effect of methanolic extract of <i>Butea monosperma</i> (Lam.) Taub. flower in male albino rats.","authors":"Shaista Parween,&nbsp;Hena Kausar,&nbsp;Imtiyaz Alam,&nbsp;Shamshun Nehar","doi":"10.4103/ayu.AYU_91_20","DOIUrl":"10.4103/ayu.AYU_91_20","url":null,"abstract":"<p><strong>Background: </strong>Search for an effective, feasible, and safe male contraceptive has been one of the major public health challenges. The present contraceptive methods are either permanent or impractical. Herbal methods are considered safe, and thus, their acceptability is higher than other prospective methods.</p><p><strong>Aims: </strong>In the present study, oral administration of methanolic extract of <i>Butea monosperma</i> (Lam.) Taub. flower was investigated for its potential role in the modulation of fertility in male albino rats.</p><p><strong>Materials and methods: </strong>Healthy male albino rats were randomly distributed into three groups, i.e., a control and two groups administered with 50 and 500 mg/kg body weight/day of methanolic extract of <i>B. monosperma</i> flower for 30, 90, and 180 days, respectively. Fertility records were maintained throughout the experimental period. At the end of experiment, animals were sacrificed and the weight of reproductive organs, sperm characteristics, and histopathology of testicular and epididymal tissues were evaluated. A 45-day withdrawal period was also investigated for parameters as described above for each group.</p><p><strong>Results: </strong>A 40% decline in fertility rate was evident in rats administered with 500 mg/kg of <i>B. monosperma</i> flower extract for 180 consecutive days. A significant reduction in testicular and epididymal weight was observed in these animals. Sperm count, motility, and viability were also reduced significantly in animals treated for 180 days. Histological evaluation of testicular cells indicated distortions in germ cell arrangements at various stages of spermatogenesis. Following 45 days of withdrawal, the resumption of normal functional and histological characteristics was apparent.</p><p><strong>Conclusion: </strong>Based on the abnormalities present in the sperm characteristics and damages in testicular histology, it was confirmed that methanolic extract of <i>B. monosperma</i> flower contain antifertility potential.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/f4/AYU-42-57.PMC9893902.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9230753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of diet supplemented with <i>Lepidium sativum (Chandrashoor)</i> on expressed breast milk volume in hypogalactic mothers - An open-label noncross-over randomized trial.","authors":"Manjiri Ranade,&nbsp;Nikhil Mudgalkar","doi":"10.4103/ayu.ayu_457_20","DOIUrl":"10.4103/ayu.ayu_457_20","url":null,"abstract":"<p><strong>Background: </strong>Hypogalactia is the common condition, especially in preterm deliveries. Some herbs in Indian medicines such as <i>Lepidium sativum L.</i> (<i>L. sativum</i>) have galactogogeus effects. The galactogogeus effect of <i>L. sativum (Chandrashoora)</i> has not been quantified in randomized control trials in humans till date. We intend to study the galactogogeus effects of <i>L. sativum</i> in hypogalactic mothers through an open-label noncross-over trial.</p><p><strong>Materials and methods: </strong>The target population were women who had delivered infants <32 weeks gestation with no lower limit to gestational age and their babies admitted in neonatal intensive care unit for prematurity. Participants who were taking specific drugs as a result of their primary illnesses, such as chemotherapy, sedatives, or antiseziure medications, were excluded. The randomization was achieved with computer-generated random number table. The experimental group (<i>n</i> = 23) received 2.5 g of <i>L. sativum (Chandrashoora</i>) seeds each day, soaked in luke warm water for half an hour in the morning, along with instructions about how to take the seeds. The control group did not receive any medication (<i>n</i> = 23). According to the institutional procedure, participants were trained to express breast milk six times using a breast pump. The amount of milk extracted was measured every day for 28 days. The difference in milk production between the two groups at 28 days was the primary endpoint. The secondary endpoint was to asses if any of the trial medicines had any adverse drug effects.</p><p><strong>Results: </strong>A total of 46 participants completed the study till 28 days. In both groups, demographic factors were comparable. The study group surpassed the control group in terms of breast milk volume slowly and reached statistical significance (<i>P</i> = 0.00002) after 28 days of therapy. No adverse drug effects were reported by the participants.</p><p><strong>Conclusion: </strong>There was statistically significant improvement in breast milk production at 28 days in hypogalactic mothers in the experimental group. <i>L. sativum</i> can be used as cheap alternatives to costly medicines to improve lactation with minimal costs and no adverse drug reactions.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/22/AYU-42-35.PMC9893899.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative diuretic evaluation of fruit and root of <i>Gokshura</i> (<i>Tribulus terrestris</i> Linn.) in albino rats.","authors":"Ankitha Sudheendran,&nbsp;M A Shajahan,&nbsp;S Premlal","doi":"10.4103/ayu.AYU_154_17","DOIUrl":"10.4103/ayu.AYU_154_17","url":null,"abstract":"<p><strong>Background: </strong><i>Gokshura Moola</i> (root of <i>Tribulus terrestris</i> Linn.) is one among the ingredients of <i>Dashamoola</i>, a group of ten medicinal plants principally comprising roots as the useful part. In practice instead of root, fruit of <i>Gokshura</i> is widely used in most of the preparations of <i>Dashamoola</i> in Kerala. <i>Dashamoola</i> occupies a significant role in a wide range of Ayurvedic formulations and holds a major share in the drug manufacturing industry. This high demand of <i>Dashamoola</i>, leads the use of fruit instead of its root and implies the need to compare the efficacy of root and fruit of <i>Gokshura</i>.</p><p><strong>Aim: </strong>This study is planned to assess whether fruit of <i>Gokshura</i> can be substituted for its root using the parameter of diuretic activity in Wistar albino rats.</p><p><strong>Materials and methods: </strong>Wistar albino rats were divided in to four groups. The group I control group and group II standard group was orally administered with carboxymethyl cellulose 2% in normal saline and furosemide (20 mg/kg) respectively. Group III was administered orally with decoction of <i>Gokshura</i> root and groups IV with <i>Gokshura</i> fruit decoction, with a dose of 8.64 ml/kg. The diuretic effect was evaluated by measuring urine volume, Na⁺, K⁺ and Cl^- ion content in urine. The results were analyzed by applying one-way ANOVA and LSD Post hoc pairwise comparison test.</p><p><strong>Results: </strong>Both test drugs in group III and group IV provided significant increase in urine output when compared to the control group (<i>P</i> < 0.001). Decoction of <i>Gokshura</i> root provided a significant increase in comparison to decoction of <i>Gokshura</i> fruit in regards of sodium (<i>P</i> < 0.01), potassium (<i>P</i> < 0.001), and chloride ion (<i>P</i> < 0.05) excretion.</p><p><strong>Conclusion: </strong>Diuretic action of both root and fruit of <i>Gokshura</i> is similar in terms of urine volume, but root is more effective in the basis of ionic excretion. Hence, while treating patients suffering from ionic imbalance, it is better to use fruit of <i>Gokshura</i> for protecting the ionic balance during diuresis. In all other conditions, root can be used for a better diuretic activity.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/f6/AYU-42-52.PMC9893904.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9230747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of <i>Vrikshayurveda</i> treatments on physiological attributes and production of diterpenoids in <i>Andrographis paniculata</i> (Burm.f.) Nees.","authors":"Gireesh M Ankad,&nbsp;Jagadishchandra Hiremath,&nbsp;Sandeep Ramchandra Pai,&nbsp;Harsha V Hegde","doi":"10.4103/ayu.ayu_311_21","DOIUrl":"10.4103/ayu.ayu_311_21","url":null,"abstract":"<p><strong>Background: </strong>An ancient text on plant life <i>Vrikshayurveda</i> mentions the use of horticulture treatments, <i>Kunapa Jala</i> (KJ) and <i>Panchagavya</i> (PG) (cow milk, cow ghee, cow curd, cow dung, and cow urine) to enhance the efficiency of plants.</p><p><strong>Aim: </strong>An experiment was conducted to evaluate the effect of KJ and PG application on total leaf area, leaf area index (LAI) leaf area duration (LAD), crop growth rate (CGR), relative growth rate (RGR), and net assimilation rate (NAR); production of andrographolide (A1), neoandrographolide (A2), and 14-deoxy-11,12-didehydroandrographolide (A3) of the <i>Andrographis paniculata</i> (Burm.f.) Nees.</p><p><strong>Materials and methods: </strong>The experiment was conducted in randomized block design with six treatments, namely control, KJ, PG, farmyard manure, inorganic fertilizer, and humic acid. Simultaneous detection of contents was carried out using reversed-phase-ultra-flow liquid chromatography (RP-UFLC). The parameters were studied at 30, 60, 90, and 120 days after sowing (DAS).</p><p><strong>Results: </strong>KJ produced higher leaf area and LAI at 90 DAS, LAD between 90 and 120 DAS. PG produced higher CGR, RGR, and NAR between 60 and 90 DAS. RP-UFLC analysis revealed the maximum amount of ingredients at 120 DAS. At this stage, PG treatment recorded the maximum amount of A1, A2, and A3.</p><p><strong>Conclusion: </strong><i>Kunapa Jala</i> and <i>Panchagavya</i> treatments were better or at par on physiological parameters and production of diterpenoids of <i>A. paniculata</i>.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/82/AYU-42-45.PMC9893900.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Pandughni Vati</i> & <i>Punarnavadi Mandura Vati</i> in the managment of <i>Pandu</i> w.s.r. iron deficiency anemia in children- An open labelled comparative clinical trial.","authors":"V K Kori,&nbsp;K S Patel","doi":"10.4103/ayu.AYU_206_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_206_20","url":null,"abstract":"<p><strong>Background: </strong>Anemia is a public health problem worldwide, and its prevalence in India is higher than any other south asian countries. Iron deficiency anemia (IDA) is having larger share out of all types of anaemia's. Symptomatology of IDA resembles with <i>Kapha</i> dominant variety of <i>Pandu</i>. <i>Pandughni</i> <i>Vati</i> (PV) and <i>Punarnavadi</i> <i>Mandura</i> (PM) <i>Vati</i> mentioned in Ayurveda are being used in clinical practice since long.</p><p><strong>Aim: </strong>To assess the efficacy of <i>Pandughni</i> <i>Vati</i> and compare its clinical efficacy with <i>Punarnavadi Mandura Vati</i> in the management of <i>Pandu</i> ws.r. iron deficiency anemia in children.</p><p><strong>Materials and methods: </strong>Present clinical study was a randomized trial for management of iron deficiency anemia aged 2-16 years. Out of total 91 patients enrolled, 60 completed the study and divided into two groups. In group A, <i>Pandughni Vati</i> (trial drug) and in group B, <i>Punarnavadi Mandura Vati</i> in the management of <i>Pandu</i> ws.r. iron deficiency anemia in children. (standard drug) were given to 30-30 patients respectively for a duration of 90 days in age specific doses. Patients were assessed by clinical signs and symptoms of <i>Pandu</i> and investigation parameters like complete blood count, serum iron, serum ferritin and total iron binding capacity (TIBC) on baseline and after 90 days of treatment. Statistical analysis was carried out by Sigma Stat software.</p><p><strong>Results: </strong>On comparison, highly significant difference was found between two groups in subjective parameters such as <i>Panduta</i> (pallor), <i>Daurbalya</i> (weakness), <i>Hriddrava</i> (palpitation), <i>Akshikuta Shotha</i> (periorbital oedema), <i>Pindikodweshtana</i> (leg cramps) and <i>Shwasa</i> (breathlessness) whereas objective and saturation percentage except serum ferritin.</p><p><strong>Conclusion: </strong>The study revealed that, both the drugs; <i>Pandughni Vati</i> and <i>Punarnavadi Mandura Vati</i> were equally effective in the management of IDA so, it could be concluded that <i>Pandughni Vati</i>, can be used as mineral-free, safe, easily obtainable, palatable, cost-effective alternative drug of choice in alternative of <i>Punarnavadi Mandura</i> in iron deficiency anemia in children.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/4a/AYU-41-218.PMC9261995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40489989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and antimicrobial study of <i>Trinakantamani (Amber</i>) <i>Pishti</i>.","authors":"Namrata Joshi,&nbsp;Meena Rani Ahuja,&nbsp;Gopal Krishan Rastogi,&nbsp;Manoj Kumar Dash","doi":"10.4103/ayu.AYU_155_19","DOIUrl":"https://doi.org/10.4103/ayu.AYU_155_19","url":null,"abstract":"<p><strong>Background: </strong><i>Trinakantamani</i> <i>Pishti</i> (TMP) is a cardio-tonic (<i>Hridya</i>), styptic (<i>Rakta</i> <i>Stambhaka</i>), astringent (<i>Kashaya</i>) formulation frequently used in varieties of bleeding disorders such as bloody diarrhea (<i>Raktatisaara</i>), <i>Raktarsha</i> (bleeding piles), and disorders of excessive menstruation (<i>Atyartava</i>). Still, no published data is available regarding its characterization.</p><p><strong>Aim: </strong>To generate a fingerprint for raw and processed TMP using sophisticated instrumental techniques to assess antimicrobial activity of TMP.</p><p><strong>Materials and methods: </strong>Three samples of TMP were prepared using the standard reference method. Characterization of TMP was carried out by Fourier-transform infrared spectroscopy (FTIR), energy dispersive X-ray analysis (EDEX) with scanning electron microscopy, powder X-ray diffraction (XRD)<b>.</b> Antibacterial activity was carried out by the well-diffusion method.</p><p><strong>Results: </strong>Analysis by scanning electron microscope revealed maximum particle size <5 μm and <3 μm in the raw sample and TMP, respectively. Minimum particle size in TMP ranges from 1 to 2 μm and 701 nm. EDEX analysis shows carbon and oxygen as major constituents while Na, Mg, Ca, Si, Fe, and S were present in traces. XRD pattern indicates the amorphous nature of the drug, while FTIR analysis reveals the presence of functional groups such as O-H, CO2, C = O, C-N, N-H. Heavy metals, total microbial count, and microbial limit test were found to be under permissible limits. Anti-microbial study against tested pathogens <i>Staphylococcus</i> <i>aureus</i>, <i>Escherichia</i> <i>coli</i>, <i>Pseudomonas</i> <i>aeruginosa</i> and <i>Salmonella</i> <i>typhimurium</i> did not show any effect of TMP.</p><p><strong>Conclusion: </strong>The results of EDEX study showed that <i>Pishti</i> samples have the small particle size i.e., 701nm than the raw i.e., 1-2 μm, which may facillitate absobtion of drug into the body. All heavy metals in the samples were within the permissible limit. Carbon, hydrogen and oxygen are the chief elements of drug which confirms similarity to the <i>Amber</i>, Since the present work is the first published literature on characterization and anti-microbial study on TMP, the outcome can be considered as fingerprint for the drug prepared using the mentioned reference method.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/40/AYU-41-225.PMC9261990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40489990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic composition, antioxidant and anti-fibrotic effects of <i>Sesbania grandiflora</i> L. (<i>Agastya</i>) - An edible medicinal plant.","authors":"Saravanakumar Arthanari,&nbsp;Parthiban Periyasamy","doi":"10.4103/ayu.AYU_198_19","DOIUrl":"https://doi.org/10.4103/ayu.AYU_198_19","url":null,"abstract":"<p><strong>Background: </strong><i>Sesbania</i> <i>grandiflora</i> (<i>S</i>. <i>grandiflora</i>/<i>Agastya</i>) is an edible Indian traditional medicinal plant widely used as dietary supplements and possesses various pharmacological activities.</p><p><strong>Aims: </strong>The aim is to evaluate aqueous ethanol extract of <i>S</i>. <i>grandiflora</i> leaves and flowers for its anti-oxidant and anti-proliferative and anti-fibrotic effects using activated rat hepatic stellate cell (HSC)-T6.</p><p><strong>Material and methods: </strong>The antioxidant activities of these plant extracts were assessed as per the standard methods and the total phenolic and flavonoid contents were examined by folin ciocalteu reagent and colorimetric methods respectively. The anti-proliferation assay was conducted by using a cyto X cell viability assay kit. The anti-fibrotic effect was investigated by measuring the hydroxyproline content and gene expression analysis of the two main fibrogenic cytokines in activated HSC-T6 cells: Transforming growth factor-beta (TGF-β) and alpha-smooth muscle actin (α-SMA).</p><p><strong>Results: </strong>The aqueous ethanol extract of <i>S</i>. <i>grandiflora</i> leaves showed the highest antioxidant activity in a concentration-dependent manner. These findings were well correlated with the total phenols and flavonoids contents. The aqueous ethanol extract of <i>S</i>. <i>grandiflora</i> leaf and flower significantly reduced the proliferation of activated HSC-T6 cells. Regarding the anti-fibrotic effect, the hydroxyproline content was significantly reduced in a concentration-dependent manner during the extract treatment. In gene expression analysis, the treatment without extracts drastically up-regulated the fibrogenic cytokines (TGF-β and α-SMA), whereas the treatment with extracts significantly reduced these alterations.</p><p><strong>Conclusion: </strong>Results of present study revealed the significant antioxidant potential of the aqueous ethanol extract of <i>S</i>. <i>grandiflora</i> leaves and flowers. Among two extracts, <i>S</i>. <i>grandiflora</i> leaves demonstrated greater antioxidant, anti-fibrotic capacity with lower inhibiting concentrations corresponding to 50% values than <i>S</i>. <i>grandiflora</i> flowers.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/b6/AYU-41-242.PMC9261989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}