Ayu最新文献

{"title":"Central nervous system depressant activity of <i>Jatamansi</i> (<i>Nardostachys jatamansi</i> DC.) rhizome.","authors":"Kalpesh Panara,&nbsp;Mukeshkumar Nariya,&nbsp;Nishteswar Karra","doi":"10.4103/ayu.AYU_251_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_251_20","url":null,"abstract":"<p><strong>Background: </strong>Sleep disorders have a comparatively high prevalence worldwide and create a burden on the health system. Pharmacological agents used for insomnia are associated with considerable side effects. Therefore, searching for safe and effective agents from plant-based natural sources is a worthy effort. <i>Jatamansi</i> (<i>Nardostachys</i> <i>jatamansi</i> DC.) rhizome has been recommended for insomnia and mental conditions in the Indian system of medicine.</p><p><strong>Aim: </strong>This study aimed to determine central nervous system (CNS) depressant activity of <i>Jatamansi</i> (<i>N</i>. <i>jatamansi)</i> rhizome on experimental animals.</p><p><strong>Materials and methods: </strong>Gross behavior study and open field test (locomotor activity) were performed by using Charle's foster albino rats whereas rota-rod test and pentobarbital-induced sleep test in <i>Swiss albino</i> mice. Animals were divided into 3 groups (per model) having six animals in each group. The control group was treated with water, the standard group with diazepam and the test drug with powder of <i>N</i>. <i>Jatamansi</i> rhizome. Results were calculated by one-way ANOVA and <i>post hoc</i> test with <i>P</i> < 0.05 as significant.</p><p><strong>Results: </strong>Data suggested that <i>Jatamansi</i> did not produce a significant effect on the behavior of animals. It reduced the horizontal activity significantly (<i>P</i> < 0.001) in the open field apparatus. The test drug did not show a significant decrease in latency of fall-off time in rota-rod performance in mice. Still, it exerted a significant effect by a reduction in latency of onset of sleep (<i>P</i> < 0.01) and also extended the total duration of sleep (<i>P</i> < 0.05) in albino mice in comparison to the control group.</p><p><strong>Conclusion: </strong>This study shows that <i>Jatamansi</i> rhizome powder possesses CNS depressant activity without affecting gross behavior and muscle coordination in rats.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 4","pages":"250-254"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/a6/AYU-41-250.PMC9261992.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40489987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reformations- A need for Ayurveda education.","authors":"Mandip Goyal","doi":"10.4103/ayu.ayu_79_22","DOIUrl":"https://doi.org/10.4103/ayu.ayu_79_22","url":null,"abstract":"The persistence and popularity of any medical science depend on the status of its upgradation. Continuous pooling of the information is required to keep any science alive and to make it applicable and suitable per the need of the society: the same is applicable to traditional systems of medicine. The Information available in the texts of traditional medicines, though is widely used by the physicians and experts, however there is extreme need to rethink and reform the information education and practices of traditional systems of in a way, it can be easily accepted in the present era. The first step to achieving this goal is the reforming of the education system. The education pattern of the traditional system should be in a format where students are taught and trained in a manner that they inculcate in themselves the thought process of thinking in a that helps to understand the ancient science in the parlance ofmodern advancements. The students trained in this way may become the torchbearer of traditional medicine where they are capable to apply the medical science appropriately. This will also build in them a real sense of confidence and trust in their own system.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 4","pages":"209-210"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/86/AYU-41-209.PMC9261996.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Guggulu</i> and <i>Shallaki</i> based <i>Ksharasutra</i> with <i>Triphala Guggulu</i> orally in the management of <i>Bhagandara</i> w.s.r. to fistula-in-ano: A open labelled randomized comparative clinical study.","authors":"Aditya Nema,&nbsp;Sanjay Kumar Gupta,&nbsp;Tukaram Dudhamal,&nbsp;Vyasdeva Mahanta","doi":"10.4103/ayu.AYU_156_16","DOIUrl":"https://doi.org/10.4103/ayu.AYU_156_16","url":null,"abstract":"<p><strong>Background: </strong><i>Bhagandara</i> is a disease of ano-rectal region and can be correlated with fistula-in-ano. <i>Ksharasutra</i> (application of medicated thread) is being practiced for ano-rectal disorders, particularly in <i>Bhagandara</i>. <i>Guggulu</i>-based <i>Ksharasutra</i> has shown good results in previous studies. Literatures and experiments of <i>Shallaki</i> showed anti-inflammatory, antifungal, analgesic, wound healing properties and <i>Shallaki</i> <i>Niryasa</i> (resin of <i>Boswellia serrate</i> Roxb.) is also having binding effect. Here, <i>Shallaki</i>-based <i>Ksharasutra</i> is used in comparison of <i>Guggulu</i>-based <i>Ksharasutra</i> with <i>Triphala</i> <i>Guggulu</i> orally for better outcome in the management of <i>Bhagandara</i>.</p><p><strong>Aim: </strong>The aim of this study was to evaluate and compare the efficacy of <i>Guggulu</i> and <i>Shallaki</i> based <i>Ksharasutra</i> with <i>Triphala</i> <i>Guggulu</i> orally in the management of <i>Bhagandara</i>.</p><p><strong>Materials and methods: </strong>Total 46 patients were registered and randomly allocated by computer generated chart by into three groups. In group A (<i>n</i> = 15), <i>Guggulu</i>-based <i>Ksharasutra</i> was applied in fistula-in-ano without any oral medication; in group B (<i>n</i> = 16), <i>Guggulu</i>-based <i>Ksharasutra</i> was applied with <i>Triphala</i> <i>Guggulu</i> orally; and in group C (<i>n</i> = 15), <i>Shallaki</i>-based <i>Ksharasutra</i> was applied with <i>Triphala</i> <i>Guggulu</i> orally. Patients were assessed for pain, discharge, itching and swelling in the affected region and unit cutting time (UCT) of fistulous tract. <i>Ksharasutra</i> was changed by railroad technique on weekly based follow-up till complete healing of the tract occurred.</p><p><strong>Results: </strong>In group A, relief in pain, discharge, and swelling was found and was statistically highly significant while insignificant result was found in itching after cut through of the fistulous tract and the same results were found in group B (<i>n</i> = 14) and group C (<i>n</i> = 15). The mean UCT was higher in group A (8.94 days/cm) than in group C (8.43 days/cm) and in group B (8.59 days/cm).</p><p><strong>Conclusion: </strong><i>Shallaki</i> based <i>Ksharasutra</i> is more effective in cutting of fistula track while <i>Guggulu</i> based <i>Ksharasutra</i> is more effective in pain relief in the treatment of <i>Bhagandara</i>, along with oral <i>Triphala</i> <i>Guggulu</i> as compared to <i>Guggulu</i> based <i>Ksharasutra</i> with and without <i>Triphala</i> <i>Guggulu</i> orally.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 4","pages":"211-217"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/44/AYU-41-211.PMC9261991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40489988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative pharmacognosy and phytochemical evaluation of leaf, root and stem of <i>Psoralea corylifolia</i> Linn. (<i>Bakuchi</i>).","authors":"Sarika Makwana,&nbsp;Nikhil Mehere,&nbsp;Prashant Bedarkar,&nbsp;Patgiri Biswajyoti,&nbsp;C R Harisha","doi":"10.4103/ayu.ayu_79_21","DOIUrl":"https://doi.org/10.4103/ayu.ayu_79_21","url":null,"abstract":"<p><strong>Background: </strong><i>Psoralea</i> <i>corylifolia</i> Linn. (<i>P</i>. <i>Corylifolia</i> L.), frequently familiar as <i>Bakuchi</i> in Samskrit, is an endangered and medicinally important plant. Its medicinal usage is reported in Indian pharmaceutical codex, the Chinese, British and the American Pharmacopoeia, and in different traditional systems of medicines such as Ayurveda, Unani and Siddha. However, no scientifically pharmacognosy study has been reported on leaf, root, and stem part of <i>P</i>. <i>Corylifolia</i> L. Classics emphasized the use of leaf, root and stem of <i>P</i>. <i>Corylifolia</i> L. for on the management of dental carries, diarrhea<b>,</b> dysentery, etc., in the form of local application as well as internal administration.</p><p><strong>Aim: </strong>The aim of this study was to evaluate comparative pharmacognosy, phytochemical studies, and physicochemical analysis of leaf, root and stem of <i>P</i>. <i>Corylifolia</i> L.</p><p><strong>Materials and methods: </strong>Studies of leaf, root, stem, and their powder for phytochemical tests, histochemical tests, psoralen chemical test, and physicochemical analysis were performed by standard methods.</p><p><strong>Result: </strong>All the different parts of the plant exhibit oleoresin and other cellular contents, i.e., vessels fibers, lignified pitted vessels, etc., in pharmacognosy studies. In phytochemical study; observations indicate that coumarins, steroids, and flavonoids are present in leaf, stem, and root samples. Basified alcoholic extracts of powders of all test samples showed yellowish color of fluorescence at 366 nm whereas none of the samples showed any color at 254 nm during chemical test of psoralen.</p><p><strong>Conclusion: </strong>Pharmacognostical study on leaf, root and stem of <i>Bakuchi</i> (<i>P. corylifolia</i> L.) contributed Certain pharmacognostical parameters i.e; oleoresin, vascular bundles, parenchyma cells with rhomboidal crystals, pericyclic fibres etc parameters that will be applicable for authentication and identification of the parts of drug. There is a need to focus on the preliminary throughput phytochemical screening of plants for their probable use in therapeutics. As no published evidences are developed on comparative pharmacognosy and preliminary physicochemical analysis of leaf, root and stem of <i>P. corylifolia</i> L. plant, the results documented in the present study may be used as a standard in subsequent studies. These observations can be of use for further research studies.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 4","pages":"235-241"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/23/AYU-41-235.PMC9261993.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40489991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptogenic and immunomodulatory activity of Virgozest <i>Avaleha</i> - An ayurvedic proprietary formulation.","authors":"Devang Y Joshi,&nbsp;Nidhi Ranpariya,&nbsp;Mukeshkumar B Nariya","doi":"10.4103/ayu.ayu_57_21","DOIUrl":"https://doi.org/10.4103/ayu.ayu_57_21","url":null,"abstract":"<p><strong>Introduction: </strong><i>Rasayana</i> (rejuvenator) or adaptogenic drugs have been proved to produce the complete potential to prevent diseases and degenerative changes that leads to diseases and promote longevity by providing strength and immunity. Virgozest <i>Avaleha</i> is a poly-herbal formulation claimed to serve as adaptogenic, and immunomodulatory, as a health tonic, enriched with dry fruits, and ingredients containing natural supplements of Vitamin E and proteins.</p><p><strong>Aim: </strong>To evaluate the adaptogenic activity and humoral immune activity of virgozest <i>Avaleha</i> in Wistar albino rats.</p><p><strong>Materials and methods: </strong>Virgozest <i>Avaleha</i> was evaluated for adaptogenic activity against swimming stress-induced changes and hypothermia in albino rats. The humoral immune activity of virgozest <i>Avaleha</i> was evaluated against sheep red blood cells (SRBCs)-induced response in albino rats with the inclusion of cyclophosphamide as immune suppressant agent.</p><p><strong>Results: </strong>In adaptogenic activity, virgozest <i>Avaleha</i> (450 and 900 mg/kg) exhibited an increase in physical activity, decrease in stress-induced hypothermia, and serum cortisol level when compared to the stress control group of albino rats. In humoral immune activity, virgozest <i>Avaleha</i> reversed the effects of cyclophosphamide-induced adverse changes on spleen and lymph node, and produced a significant increase in serum antibody titer in SRBCs-sensitized rats.</p><p><strong>Conclusion: </strong>The present study concluded that virgozest <i>Avaleha</i> has adaptogenic and humoral immune activity in Wistar albino rats, which may suggest the <i>Rasayana</i> like properties of Ayurvedic formulation.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 4","pages":"255-261"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/a9/AYU-41-255.PMC9261994.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Guduchighana Vati in asymptomatic and mild-to-moderate cases of coronavirus disease-19: A randomized controlled pilot study","authors":"A. Rai, U. Shukla, Nitin Ujjaliya, Pankaj Gupta, V. Khare, B. Yadav, Hetalben Amin, Rakesh Rana, Arunabh Tripathi, S. Khanduri, B. Sharma, B. Chandrasekhararao, Narayanam Srikanth, K. Dhiman","doi":"10.4103/ayu.ayu_11_21","DOIUrl":"https://doi.org/10.4103/ayu.ayu_11_21","url":null,"abstract":"Background: Currently, there is no approved treatment for the management of coronavirus disease (COVID-19). Drug repurposing of existing medications could be a possible way to find out a novel therapeutic entity to combat the COVID-19. Aim: To determine the clinical efficacy and safety of an Ayurveda intervention (Guduchighana Vati) in asymptomatic and mild-to-moderate cases of COVID-19. Materials and methods: This was an open-label randomized controlled pilot study with a sample size of 30 participants (15 in each arm). The participants were asymptomatic or mild to moderate cases of COVID-19. Guduchighana Vati 500 mg twice daily for 10 days was administered in the study group and Hydroxychloroquine for 5 days in the control group. Paracetamol, Vitamin C, Multivitamin, and Zinc were also provided in the control group. The main outcome measures were to negative real-time reverse transcription–polymerase chain reaction (RT-PCR) assay for COVID-19, proportion of participants with negative RT-PCR for COVID-19 at 5th and 10th day, proportion of participants with clinical recovery, improvement in laboratory parameters, and incidence of adverse drug reaction/adverse event (ADR/AE). The results of RT-PCR and clinical recovery were compared between groups using Chi-square test. The data related to laboratory parameters were compared within group using paired sample t-test/Wilcoxon signed-rank test and between groups using independent sample t-test/Mann–Whitney test. Results: The proportion of participants with negative RT-PCR for COVID-19 in the Guduchighana Vati group (93.3%) was better as compared to the control group (66.6%) till 10th day of the study period. Though, the results are statistically not significant (P = 0.068). All the symptomatic patients in the Guduchighana Vati group clinically recovered whereas one patient remained symptomatic in the control group on the 5th day. No symptoms of COVID-19 were observed at 10th day in both the groups. No ADR/serious adverse event were observed during the study period in either of the groups. Conclusion: In this study on asymptomatic and mild to moderate cases of COVID-19, Guduchighana Vati showed numerically better proportion of participants with negative RT-PCR assay for COVID-19 and reduced time to clinical improvement which requires confirmation through studies with larger sample size. Although, the study outcomes are statistically not significant which may be due to small sample size.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"20 1","pages":"188 - 196"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81701607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative pharmaceutico-analytical study of Rasamanikya prepared by two different Shodhana media of Haratala (orpiment)","authors":"Dipali Parekh, Sarika M. Makwana, P. Bedarkar, B. Patgiri","doi":"10.4103/ayu.AYU_261_19","DOIUrl":"https://doi.org/10.4103/ayu.AYU_261_19","url":null,"abstract":"Introduction: Foremost, Rasamanikya is described in Rasendra Chintamani by Acharya Dhundhuknath. It is a formulation that is prepared from the arsenical drug, i.e., orpiment (Haratala). Haratala is classified under Uparasa Varga in Rasa classics and is also included under Schedule E1 in D and C act 1940. In classics, there are so many media mentioned for purification process (Shodhana) of orpiment. In the present study, Kushmanda Swarasa (juice of Benincasa hispida [Thunb.] Cogn) and Churnodaka (lime water) are adopted as the purification media for orpiment. Aim: The aim of this study was to standardize the pharmaceutical procedure of Rasamanikya and develop a comparative analytical profile of both the formulation, i.e., Rasamanikya prepared by Kushmanda Swarasa and Churnodaka Shodhita Haratala. Materials and methods: The study was carried out in two stages as follows: Shodhana of Haratala and preparation of Rasamanikya by Kupipakwa method. Both the samples of Rasamanikya were analyzed for organoleptic and physicochemical parameters. The samples of final products were also analyzed through sophisticated analytical parameters, i.e., X-ray diffraction (XRD), Inductively coupled plasma-atomic emission spectroscopy (ICP-AES), CHNS and O, Field emission gun-scanning electron microscopy (FEG-SEM), Fourier transform infrared spectroscopy (FTIR) and Thermo-gravimetric analysis (TGA). Results: Average 2 h duration was required for the preparation of Rasamanikya formulation from 600 g of purified orpiment. In XRD analysis, both samples have different diffraction patterns. In ICP-AES analysis, both samples have the same percentage of arsenic. More percentage loss was noted in the TGA of Rasamanikya prepared with Churnodaka Shodhita Haratala than that of Kushmanda Swarasa Shodhita Haratala. Conclusion: Rasamanikya prepared by two different media of Shodhita Haratala did not found to have a substantial difference in pharmaceutical procedure. However, there was a considerable difference in the analytical study. Kupipakwa procedure can be used for large-scale preparation.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"103 1","pages":"197 - 207"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82736945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Vyoshadi Guggulu and Shadushana Churna in the management of subclinical hypothyroidism: An open labelled randomized comparative pilot clinical trial","authors":"V. B. Sharma, B. Padhar, H. Meena, S. Mathur","doi":"10.4103/ayu.ayu_359_20","DOIUrl":"https://doi.org/10.4103/ayu.ayu_359_20","url":null,"abstract":"Background: Subclinical hypothyroidism (SCH) is defined as a mildly reduced function of the thyroid gland having elevated serum thyroid-stimulating hormone (TSH) level and normal concentrations of free tri-iodothyronine (FT3), free tetra-iodothyronine (FT4), T3 and T4. It occurs due to “Agnimandya” (low metabolic activity) at the systemic and cellular level. Vyoshadi Guggulu and Shadushana Churna having its effect on Agni (a root cause of SCH) are expected to prevent overt hypothyroidism and revert subclinical stage to euthyroid. Aim: This study was planned to evaluate and compare the efficacy of Vyoshadi Guggulu and Shadushana Churna in the management of Dhatvagnimandya with special reference to sub-clinical hypothyroidism (SCH). Materials and methods: Patients having serum TSH levels between 5 and 10 mlU/L and normal T3 and T4 values were diagnosed as SCH. A total of 30 patients were registered and randomly divided into two groups. In group A, patients were treated with Vyoshadi Guggulu (6 g), while in group B with Shadushana Churna (3 g) twice a day after lunch and dinner for 60 days. The assessment was done through changes in baseline and after treatment values of serum TSH level. Outcomes of the trial were analyzed using SigmaStat 4.0 version (trial) software. Student's paired t-test was used for within-group assessment, while unpaired t-test was used for intergroup comparison of the normally distributed parametric data. Observations and Results: Ten patients in group A and 11 in group B could complete the course of treatment. The findings revealed that therapy in group A and B showed decrease of 16.61% (P = 0.0494) and 26.29% (P = 0.0140) in serum TSH, respectively, 1.80% (P = 0.025) and 1.36% (P = 0.019) decrease in body mass index (BMI), respectively. The decrease in TSH and BMI was statistically significant in each group. In comparison, the decrease in serum TSH (P = 0.384) and BMI (P = 0.677) was statistically insignificant. Conclusions: Vyoshadi Guggulu and Shadushana Churna are statistically equally effective to reduce serum TSH and BMI in the management of SCH.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"102 1","pages":"181 - 187"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90075544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Virechana, Triphaladi decoction with processed Guggulu in the management of ovarian cyst - A pilot study","authors":"Matangee Pandya, S. Donga, L. Dei, A. Thakar","doi":"10.4103/ayu.AYU_254_19","DOIUrl":"https://doi.org/10.4103/ayu.AYU_254_19","url":null,"abstract":"Background: Ovarian cyst is an emerging problem among the women of reproductive age group. Most of the ovarian cyst (80%–85%) are benign, and two-thirds of these occur in women between 20 and 44 years of age. They may be identified in asymptomatic women during routine pelvic examination or may produce symptoms. Management of the ovarian cyst through surgery is available to meet urgent need of the patient, but to establish a satisfactory conservatory medical treatment is the need of the hour. According to Ayurveda, ovarian cysts can be managed on the line of Kaphaja Granthi (nodular/glandular swellings by Kapha Dosha) and Vidradhi (abscess). Aim: The aim of this study was to evaluate the clinical efficacy of Virechana (therapeutic purgation), Triphaladi Kashaya (decoction) with processed Guggulu (Commiphora mukul Engl.) in the management of ovarian cyst. Materials and methods: 16 patients were included in this clinical study and among them, 15 patients completed the treatment and one patient was dropped out from the trial. Patients were given Virechana followed by Triphaladi Kashaya (50 ml) with processed Guggulu (1 g) orally twice a day before meal for 60 days. The patients were followed up till 1 month. The assessment was carried out on subjective parameters such as lower abdominal pain, backache, and dysmenorrhea as well as objective parameters such as ovarian cyst size and volume by four-dimensional gray scale and color doppler sonography. Cancer antigen 125 was also assessed before and after treatment. Results were statistically analyzed using Wilcoxon signed-rank test and Student's t-test by sigma statistical tool (version 3.5, Systat Software Inc., United States). Results: Significant results were observed in subjective parameters such as lower abdominal pain (93.11%), backache (81.81) and dysmenorrhea (90.90%) as well as objective parameters such as reduction in size of the cyst (60%) and complete resolution of the cyst (26.66%). Conclusion: Triphaladi Kashaya with processed Guggulu is more effective in hemorrhagic cyst and simple cyst rather than other cyst, due to Shothahara properties which may have effectively curtailed the progress of ovarian cyst.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"25 1","pages":"166 - 172"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90350318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Laksha Churna and Madhu Pratisarana after ultrasonic scaling in the management of Dantasharkara (dental calculus): An open-label, standard controlled randomized clinical trial","authors":"Divyarani Kathad, Hemangi Shukla, M. Goyal","doi":"10.4103/ayu.AYU_274_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_274_20","url":null,"abstract":"Background: Dental calculus is one of the major problems in dentistry, which is characterized by calcified mass that forms on and adheres to the surface of teeth resulting in bad breath, receding gums and chronically inflamed gingiva. It can be correlated with Dantasharkara (dental calculus), which is characterized by the collection of hardened accumulation of Mala (tartar) at the junction of teeth and gums. Ultrasonic scalars are used for the removal of dental calculus for convenience. In texts, Laksha Churna (powder of Laccifer lacca Kerr) has been mentioned as Vranaropaka (wound healing) and indicated for the eliminating plaque through cleaning and polishing tooth surfaces. Aim: This study was aimed to evaluate the clinical efficacy of local application of Laksha Churna and Madhu (honey) Pratisarana after Dantasharkara Nirharana (scaling of dental calculus) in the management of Dantasharkara (dental calculus). Materials and methods: Patients having calculus deposition, fulfilling the inclusion criteria were selected. In group A, Pratisarana with Laksha Churna (powder) 1 g and Madhu as per requirement was given, whereas in group B, chlor-hexidine gluconate 0.2% for gargling was given for 2 weeks. Ultrasonic scaling was done in both groups before given trial drugs. The outcomes were calculated on the base on changes in score of the subjective parameters like pain, inflammation of gum, bleeding gums, halitosis as well as objective parameters like oral hygiene index, debris index, calculus index, gingival index, and periodontal index. For analysing the effect of the result, Wilcoxon signed-rank test for nonparametric paired data and paired t-test for quantitative parametric paired data was applied. Results: After analysing the data, it was found that Ultrasonic scaling of dental calculus followed by Pratisaraņa of honey with Laksha Churna provided statistically significant improvement in calculus index (97.77%) in debris index (84.44%), in oral hygiene index(96.66%), in gingival index (83.33%)and showed 96.15% improvement in periodontal index, whereas Ultrasonic scaling of dental calculus followed by gargling with chlorhexidine gluconate 0.2% provided 80% improvement in calculus index, 70% in debris index, 90% in oral hygiene index, in gingival index by 73.06%, and 93.75% improvement periodontal index which was statistically significant. Conclusion: The present study indicates Dantasharkara Nirharana followed by Pratisarana of Laksha Churna and Madhu is comparatively more effective than conventional standard treatment protocol (ultrasonic scaling and chlorhexidine gluconate mouth wash) in the management of dental calculus.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"70 1","pages":"173 - 180"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77193831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}