{"title":"Guggulu和Shallaki为基础的Ksharasutra联合Triphala Guggulu口服治疗Bhagandara w.s.r.瘘管的疗效:一项开放标记随机对照临床研究。","authors":"Aditya Nema, Sanjay Kumar Gupta, Tukaram Dudhamal, Vyasdeva Mahanta","doi":"10.4103/ayu.AYU_156_16","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Bhagandara</i> is a disease of ano-rectal region and can be correlated with fistula-in-ano. <i>Ksharasutra</i> (application of medicated thread) is being practiced for ano-rectal disorders, particularly in <i>Bhagandara</i>. <i>Guggulu</i>-based <i>Ksharasutra</i> has shown good results in previous studies. Literatures and experiments of <i>Shallaki</i> showed anti-inflammatory, antifungal, analgesic, wound healing properties and <i>Shallaki</i> <i>Niryasa</i> (resin of <i>Boswellia serrate</i> Roxb.) is also having binding effect. Here, <i>Shallaki</i>-based <i>Ksharasutra</i> is used in comparison of <i>Guggulu</i>-based <i>Ksharasutra</i> with <i>Triphala</i> <i>Guggulu</i> orally for better outcome in the management of <i>Bhagandara</i>.</p><p><strong>Aim: </strong>The aim of this study was to evaluate and compare the efficacy of <i>Guggulu</i> and <i>Shallaki</i> based <i>Ksharasutra</i> with <i>Triphala</i> <i>Guggulu</i> orally in the management of <i>Bhagandara</i>.</p><p><strong>Materials and methods: </strong>Total 46 patients were registered and randomly allocated by computer generated chart by into three groups. In group A (<i>n</i> = 15), <i>Guggulu</i>-based <i>Ksharasutra</i> was applied in fistula-in-ano without any oral medication; in group B (<i>n</i> = 16), <i>Guggulu</i>-based <i>Ksharasutra</i> was applied with <i>Triphala</i> <i>Guggulu</i> orally; and in group C (<i>n</i> = 15), <i>Shallaki</i>-based <i>Ksharasutra</i> was applied with <i>Triphala</i> <i>Guggulu</i> orally. Patients were assessed for pain, discharge, itching and swelling in the affected region and unit cutting time (UCT) of fistulous tract. <i>Ksharasutra</i> was changed by railroad technique on weekly based follow-up till complete healing of the tract occurred.</p><p><strong>Results: </strong>In group A, relief in pain, discharge, and swelling was found and was statistically highly significant while insignificant result was found in itching after cut through of the fistulous tract and the same results were found in group B (<i>n</i> = 14) and group C (<i>n</i> = 15). The mean UCT was higher in group A (8.94 days/cm) than in group C (8.43 days/cm) and in group B (8.59 days/cm).</p><p><strong>Conclusion: </strong><i>Shallaki</i> based <i>Ksharasutra</i> is more effective in cutting of fistula track while <i>Guggulu</i> based <i>Ksharasutra</i> is more effective in pain relief in the treatment of <i>Bhagandara</i>, along with oral <i>Triphala</i> <i>Guggulu</i> as compared to <i>Guggulu</i> based <i>Ksharasutra</i> with and without <i>Triphala</i> <i>Guggulu</i> orally.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/44/AYU-41-211.PMC9261991.pdf","citationCount":"0","resultStr":"{\"title\":\"Efficacy of <i>Guggulu</i> and <i>Shallaki</i> based <i>Ksharasutra</i> with <i>Triphala Guggulu</i> orally in the management of <i>Bhagandara</i> w.s.r. to fistula-in-ano: A open labelled randomized comparative clinical study.\",\"authors\":\"Aditya Nema, Sanjay Kumar Gupta, Tukaram Dudhamal, Vyasdeva Mahanta\",\"doi\":\"10.4103/ayu.AYU_156_16\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><i>Bhagandara</i> is a disease of ano-rectal region and can be correlated with fistula-in-ano. <i>Ksharasutra</i> (application of medicated thread) is being practiced for ano-rectal disorders, particularly in <i>Bhagandara</i>. <i>Guggulu</i>-based <i>Ksharasutra</i> has shown good results in previous studies. Literatures and experiments of <i>Shallaki</i> showed anti-inflammatory, antifungal, analgesic, wound healing properties and <i>Shallaki</i> <i>Niryasa</i> (resin of <i>Boswellia serrate</i> Roxb.) is also having binding effect. Here, <i>Shallaki</i>-based <i>Ksharasutra</i> is used in comparison of <i>Guggulu</i>-based <i>Ksharasutra</i> with <i>Triphala</i> <i>Guggulu</i> orally for better outcome in the management of <i>Bhagandara</i>.</p><p><strong>Aim: </strong>The aim of this study was to evaluate and compare the efficacy of <i>Guggulu</i> and <i>Shallaki</i> based <i>Ksharasutra</i> with <i>Triphala</i> <i>Guggulu</i> orally in the management of <i>Bhagandara</i>.</p><p><strong>Materials and methods: </strong>Total 46 patients were registered and randomly allocated by computer generated chart by into three groups. In group A (<i>n</i> = 15), <i>Guggulu</i>-based <i>Ksharasutra</i> was applied in fistula-in-ano without any oral medication; in group B (<i>n</i> = 16), <i>Guggulu</i>-based <i>Ksharasutra</i> was applied with <i>Triphala</i> <i>Guggulu</i> orally; and in group C (<i>n</i> = 15), <i>Shallaki</i>-based <i>Ksharasutra</i> was applied with <i>Triphala</i> <i>Guggulu</i> orally. Patients were assessed for pain, discharge, itching and swelling in the affected region and unit cutting time (UCT) of fistulous tract. <i>Ksharasutra</i> was changed by railroad technique on weekly based follow-up till complete healing of the tract occurred.</p><p><strong>Results: </strong>In group A, relief in pain, discharge, and swelling was found and was statistically highly significant while insignificant result was found in itching after cut through of the fistulous tract and the same results were found in group B (<i>n</i> = 14) and group C (<i>n</i> = 15). The mean UCT was higher in group A (8.94 days/cm) than in group C (8.43 days/cm) and in group B (8.59 days/cm).</p><p><strong>Conclusion: </strong><i>Shallaki</i> based <i>Ksharasutra</i> is more effective in cutting of fistula track while <i>Guggulu</i> based <i>Ksharasutra</i> is more effective in pain relief in the treatment of <i>Bhagandara</i>, along with oral <i>Triphala</i> <i>Guggulu</i> as compared to <i>Guggulu</i> based <i>Ksharasutra</i> with and without <i>Triphala</i> <i>Guggulu</i> orally.</p>\",\"PeriodicalId\":8720,\"journal\":{\"name\":\"Ayu\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/44/AYU-41-211.PMC9261991.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ayu\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ayu.AYU_156_16\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/6/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.AYU_156_16","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/6/3 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:Bhagandara是一种肛肠区疾病，可与肛瘘相关。Ksharasutra(应用药物线)正在用于肛肠疾病，特别是在巴甘达拉。以古古鲁为基础的Ksharasutra在之前的研究中显示出良好的结果。文献和实验表明，夏拉木具有抗炎、抗真菌、镇痛、伤口愈合等作用，夏拉木树脂也具有结合作用。在这里，Shallaki-based Ksharasutra被用来比较guguulu -based Ksharasutra和Triphala guguulu口服药，以获得更好的治疗效果。目的:本研究的目的是评价和比较古古鲁和夏拉基口服法与Triphala古古鲁口服法治疗大腹大肠炎的疗效。材料与方法:纳入46例患者，采用计算机生成图表法随机分为3组。A组(n = 15)采用guggulu - Ksharasutra治疗瘘管，不使用任何口服药物;B组(n = 16)采用gugugulu为基础的Ksharasutra联合Triphala gugugulu口服;C组(n = 15)应用夏拉基法经加口服三七。评估患者患区疼痛、分泌物、瘙痒、肿胀及瘘道单位切割时间(UCT)。在每周一次的随访中，采用铁路技术改变经络，直至尿道完全愈合。结果:A组患者疼痛、分泌物、肿胀均有明显缓解，且差异有统计学意义，而瘘道切开后瘙痒无统计学意义，B组(n = 14)、C组(n = 15)差异无统计学意义。A组平均UCT (8.94 d /cm)高于C组(8.43 d /cm)和B组(8.59 d /cm)。结论:以Shallaki为基础的经切瘘道更有效，而以guguulu为基础的经切瘘道更有效，与口服Triphala gugugululu相比，以guguulu为基础的经切瘘术与口服Triphala gugugululu相比，在治疗Bhagandara时口服Triphala gugugululu更有效。
Efficacy of Guggulu and Shallaki based Ksharasutra with Triphala Guggulu orally in the management of Bhagandara w.s.r. to fistula-in-ano: A open labelled randomized comparative clinical study.
Background: Bhagandara is a disease of ano-rectal region and can be correlated with fistula-in-ano. Ksharasutra (application of medicated thread) is being practiced for ano-rectal disorders, particularly in Bhagandara. Guggulu-based Ksharasutra has shown good results in previous studies. Literatures and experiments of Shallaki showed anti-inflammatory, antifungal, analgesic, wound healing properties and ShallakiNiryasa (resin of Boswellia serrate Roxb.) is also having binding effect. Here, Shallaki-based Ksharasutra is used in comparison of Guggulu-based Ksharasutra with TriphalaGuggulu orally for better outcome in the management of Bhagandara.
Aim: The aim of this study was to evaluate and compare the efficacy of Guggulu and Shallaki based Ksharasutra with TriphalaGuggulu orally in the management of Bhagandara.
Materials and methods: Total 46 patients were registered and randomly allocated by computer generated chart by into three groups. In group A (n = 15), Guggulu-based Ksharasutra was applied in fistula-in-ano without any oral medication; in group B (n = 16), Guggulu-based Ksharasutra was applied with TriphalaGuggulu orally; and in group C (n = 15), Shallaki-based Ksharasutra was applied with TriphalaGuggulu orally. Patients were assessed for pain, discharge, itching and swelling in the affected region and unit cutting time (UCT) of fistulous tract. Ksharasutra was changed by railroad technique on weekly based follow-up till complete healing of the tract occurred.
Results: In group A, relief in pain, discharge, and swelling was found and was statistically highly significant while insignificant result was found in itching after cut through of the fistulous tract and the same results were found in group B (n = 14) and group C (n = 15). The mean UCT was higher in group A (8.94 days/cm) than in group C (8.43 days/cm) and in group B (8.59 days/cm).
Conclusion: Shallaki based Ksharasutra is more effective in cutting of fistula track while Guggulu based Ksharasutra is more effective in pain relief in the treatment of Bhagandara, along with oral TriphalaGuggulu as compared to Guggulu based Ksharasutra with and without TriphalaGuggulu orally.
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