Arquivos de neuro-psiquiatria最新文献_第2页

Postictal status and clinical variables in adults with epilepsy. 成人癫痫患者的术后状态和临床变量。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI: 10.1055/s-0045-1811625

Cecília Fusco Agostinho, Glória M A S Tedrus

{"title":"Postictal status and clinical variables in adults with epilepsy.","authors":"Cecília Fusco Agostinho, Glória M A S Tedrus","doi":"10.1055/s-0045-1811625","DOIUrl":"https://doi.org/10.1055/s-0045-1811625","url":null,"abstract":"Symptoms in the postictal period are often neglected by professionals and patients/family members.To relate the characteristics of the postictal period with the clinical variables of adult patients with epilepsy.Prospectively, the clinical characteristics of the postictal period were related to the clinical variables and the scores on the Hospital Anxiety and Depression Scale (HADS) and Mini-Mental State Examination (MMSE) of 70 patients with epilepsy.The mean age was 47.6 years old, and 34 (48.6%) patients were male, the mean age at onset of epilepsy was 20.3 years old, the epileptic syndrome was structural in 48 cases, the mean score in the MMSE was 23.6, the mean score in the HADS-anxiety was 7.3, and in the HADS-depression it was 5.6. Postictal manifestation occurred in 59 (84.2%) cases, with prolonged duration in 22 (37.2%) cases. There was a difference in the duration and presence of postictal manifestation according to age at the onset of epilepsy. Higher HADS-anxiety scores were associated with the presence of confusion in the postictal period (t-test; 9.3 ± 6.8 versus 5.8 ± 4.8; p = 0.015). Lower MMSE scores were related to postictal anxiety and sleepiness/headache/confusion. Left-sided epileptiform activity (EA) was associated with postictal sleepiness/headache/confusion. There was a difference in postictal manifestation according to epileptic syndrome.The characteristics of the postictal period differed according to the age of onset, the type of seizure, and the epileptic syndrome. Different symptoms in the postictal period were associated with the scores on HADS anxiety, MMSE, and left-sided EA on the electroencephalogram.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 9","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcitonin gene-related peptide monoclonal antibodies and medication-overuse headache: stopping excessive pain medication is still necessary. 降钙素基因相关肽单克隆抗体与药物过度使用头痛：停止过度止痛药仍然是必要的。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1055/s-0045-1809332

Pedro Augusto Sampaio Rocha-Filho

引用次数: 0

A Brazilian Minamata disease? Neurologists must be aware of mercury exposure and intoxication. 巴西的水俣病？神经科医生必须注意汞暴露和中毒。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI: 10.1055/s-0045-1811622

Gustavo Maximiano-Alves, Eder Leandro da Silva Dantas, Maria Elena Crespo-Lopez, José Luiz Martins do Nascimento

{"title":"A Brazilian Minamata disease? Neurologists must be aware of mercury exposure and intoxication.","authors":"Gustavo Maximiano-Alves, Eder Leandro da Silva Dantas, Maria Elena Crespo-Lopez, José Luiz Martins do Nascimento","doi":"10.1055/s-0045-1811622","DOIUrl":"https://doi.org/10.1055/s-0045-1811622","url":null,"abstract":"Mercury intoxication poses a significant challenge and growing threat to public health, particularly in the Amazon region. Despite a known history of neurological damage, as evidenced by Japan's Minamata disease, mercury intoxication remains underdiagnosed in Brazil. This review underscores the need for increased clinical awareness among neurologists, as mercury exposure has been linked to over 250 neurological symptoms, including cognitive impairment, cerebellar ataxia, peripheral neuropathy, and psychiatric disturbances. The Indigenous and riverside populations in the Amazon present a high prevalence of cognitive and motor deficits, tremors, and sensory disturbances, which are associated with mercury body burdens. Diagnosis relies on a combination of clinical suspicion, environmental exposure history, and biomonitoring through hair and urine analyses. Given the widespread environmental contamination and potential long-term health consequences, neurologists must be vigilant in recognizing and managing mercury-related neurotoxicity, particularly in vulnerable Brazilian populations.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 9","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erdheim-Chester manifesting purely as a neurological disease. 厄德海姆-切斯特症候群纯粹表现为神经系统疾病

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-09-01 Epub Date: 2025-06-21 DOI: 10.1055/s-0045-1809403

Lídia Laura Salvador Ramos, Iago Resende Carvalho, Diogo Fernandes Dos Santos, Andrea de Martino Luppi, Bruno de Carvalho Dornelas

引用次数: 0

Assessment of possible small fiber Neuropathy in early-stage vitamin B12 deficiency using electrophysiological methods. 利用电生理方法评估早期维生素B12缺乏症可能的小纤维神经病变。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-09-01 Epub Date: 2025-09-19 DOI: 10.1055/s-0045-1811722

Elif Simin Issi

{"title":"Assessment of possible small fiber Neuropathy in early-stage vitamin B12 deficiency using electrophysiological methods.","authors":"Elif Simin Issi","doi":"10.1055/s-0045-1811722","DOIUrl":"10.1055/s-0045-1811722","url":null,"abstract":"Small fiber neuropathy (SFN) affects thinly myelinated and unmyelinated fibers, often presenting with subtle clinical signs that are undetectable in routine nerve conduction studies. Vitamin B12 deficiency is a known risk factor for SFN, yet early-stage cases frequently remain undiagnosed. Sympathetic skin response (SSR) and cutaneous silent period (CSP) are noninvasive electrophysiological techniques used to assess autonomic and somatic small fiber function.The present study aimed to evaluate the diagnostic utility of SSR and CSP in detecting possible subclinical small-fiber neuropathy (pSFN) in individuals with early-stage vitamin B12 deficiency.The present observational study included 28 patients with vitamin B12 deficiency who had nonspecific complaints, Douleur Neuropathique en 4 Questions (DN4) scores < 4, and normal nerve conduction studies, along with 25 healthy controls. Electrophysiological testing involved SSR recordings from all extremities and CSP measurements from the right median and sural nerves.In the patient group, Median Nerve Cutaneous Silent Period (MN-CSP) and Tibialis Anterior -Sural Cutaneous Silent Period (TA-sural CSP) durations were significantly shorter, while termination and onset latencies were prolonged compared with controls. MN-CSP and TA-sural CSP durations demonstrated high diagnostic accuracy. Sympathetic skin response latencies were significantly prolonged in both hands and feet, indicating autonomic dysfunction. No significant differences were observed in SSR amplitudes.Sympathetic skin response and CSP are valuable tools for detecting possible subclinical SFN in vitamin B12 deficiency. Sympathetic skin response effectively identified autonomic dysfunction, while CSP provided additional diagnostic value for somatic small fiber impairment. Combining SSR and CSP may enhance early detection of pSFN in vitamin B12 deficiency and allow timely intervention.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 9","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuroscience of music perception: a narrative review. 音乐感知的神经科学：叙述性回顾。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-09-01 Epub Date: 2025-08-31 DOI: 10.1055/s-0045-1811233

Renan Barros Domingues, Luísa Aires Domingues, Victor Rebelo Procaci, José Luiz Pedroso

引用次数: 0

Profile and postrehabilitation outcome of patients with vertigo in a clinic in Southern Santa Catarina. 南圣卡塔琳娜州一家诊所眩晕患者的概况和康复后结果。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.1055/s-0045-1811175

Emanuela Hannoff Pilon, Vitor Benincá-Fernandes, Letícia Fernandes, Karina Rossa, Tatiana Pizzolotto Bruch

{"title":"Profile and postrehabilitation outcome of patients with vertigo in a clinic in Southern Santa Catarina.","authors":"Emanuela Hannoff Pilon, Vitor Benincá-Fernandes, Letícia Fernandes, Karina Rossa, Tatiana Pizzolotto Bruch","doi":"10.1055/s-0045-1811175","DOIUrl":"https://doi.org/10.1055/s-0045-1811175","url":null,"abstract":"For the purposes of the present study, we define vertigo as the sensation of rotation of the environment or of the person moving. The demand for care for this complaint has been increasing; therefore, it is important to know the profile of patients treated with this complaint, the causes, the comorbidities, the associated factors, and the response of these individuals to rehabilitation.To analyze the epidemiological profile of patients reporting vertigo and their outcome after physiotherapeutic rehabilitation.We conducted a descriptive cross-sectional study of secondary data analysis. The sample was collected through a census in a specialized clinic in the south of the state of Santa Catarina, Brazil. Individuals were evaluated through a questionnaire developed by the authors, which covered the patient's demographic and clinical data. The statistical analysis was performed using the IBM SPSS Statistics for Windows (IBM Corp.) software, version 23.0.A total of 200 medical records were evaluated, 5 of which were excluded due to non-adherence to treatment, totaling a sample of 195 patients. Their mean age was of 51.18 ± 16.84 years, 62.6% were female subjects, and benign paroxysmal positional vertigo (BPPV) was the most prevalent cause (55.9%), with associated symptoms such as tinnitus (30.8%) and depression and/or anxiety (29.2%). Of the 195 patients, 193 responded positively to the vestibular rehabilitation treatment, and the vertigo of 58% improved after 1 session.The population older than 50 years of age is the most affected by vertigo, especially women, with BPPV as the main cause and associated symptoms such as tinnitus, depression, and anxiety. Most patients improved after the first vestibular rehabilitation session.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 8","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cerebellum and psychiatric disorders: unraveling its role in mental health. 小脑和精神疾病：揭示其在心理健康中的作用。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.1055/s-0045-1810408

Pedro Braga-Neto, Maria Wanessa Barbosa Dos Santos, Stephanie Suzanne de Oliveira Scott, Renato Puppi Munhoz, Luiz Eduardo Novis, José Luiz Pedroso, Orlando Graziani Povoas Barsottini

引用次数: 0

Adrenocorticotropic hormone combined with vigabatrin as a second-line therapy for West syndrome. 促肾上腺皮质激素联合维加巴特林作为西氏综合征的二线治疗。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-08-01 Epub Date: 2025-08-20 DOI: 10.1055/s-0045-1811172

Luciana de Paula Souza, Danielle Caldas Bufara, Tallulah Spina Tensini, Sergio Antonio Antoniuk, Gustavo L Franklin, Ana Chrystina de Souza Crippa

{"title":"Adrenocorticotropic hormone combined with vigabatrin as a second-line therapy for West syndrome.","authors":"Luciana de Paula Souza, Danielle Caldas Bufara, Tallulah Spina Tensini, Sergio Antonio Antoniuk, Gustavo L Franklin, Ana Chrystina de Souza Crippa","doi":"10.1055/s-0045-1811172","DOIUrl":"https://doi.org/10.1055/s-0045-1811172","url":null,"abstract":"West syndrome is an epileptic encephalopathy for which combination therapies with adrenocorticotropic hormone and vigabatrin have emerged as new treatment options.To evaluate the clinical and electroencephalographic remission rates, tolerability, and relapse rates in patients with West syndrome who failed primary treatment and underwent sequential therapy with vigabatrin and adrenocorticotropic hormone.We included 39 patients with West syndrome from 2 specialized centers, aged 2 to 120 months. The patients were treated with intramuscular tetracosactide depot added to vigabatrin and were prospectively followed up for ≥ 1 year. The outcomes were clinical, and electroencephalographic remission rates at 7 and 30 days and 1 year following combined therapy initiation, progression to other epilepsy types, therapy tolerability, and relapse rates were recorded.Of the original sample, 71% of the subjects were boys, and 87% had a known etiology. The clinical and electroencephalographic remission rates were 46.1%, 94.8% (p = 0.001), and 74.1% (p = 0.01) at 7 and 30 days, and 1 year after the initiation of combined therapy, respectively. At the 1-year follow-up, adverse effects were observed in 86.0% and the relapse rate was 21.6%. After a median follow-up of 21 months, 73.6% of the patients developed epilepsy.Combined therapy demonstrated a favorable efficacy profile in achieving clinical and electroencephalographic remission but was associated with significant seizure relapse rates in the medium term. Thus, it represents a feasible option for patients in whom initial treatment has failed.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 8","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticotherapy versus adrenocorticotropic hormone for treating West syndrome: a systematic review and meta-analysis. 皮质疗法与促肾上腺皮质激素治疗西综合征：系统回顾和荟萃分析。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.1055/s-0045-1811173

Elizabeth Honorato de Farias, Anderson Matheus Pereira da Silva, Karlos Daniell Araújo Dos Santos, Altair Pereira de Melo Neto, Aishwarya Koppanatham, Júlia Cappi Aguiar Moraes Souza, Niels Pacheco-Barrios, Gabrielle de Souza Rocha, Gustavo Sousa Noleto

{"title":"Corticotherapy versus adrenocorticotropic hormone for treating West syndrome: a systematic review and meta-analysis.","authors":"Elizabeth Honorato de Farias, Anderson Matheus Pereira da Silva, Karlos Daniell Araújo Dos Santos, Altair Pereira de Melo Neto, Aishwarya Koppanatham, Júlia Cappi Aguiar Moraes Souza, Niels Pacheco-Barrios, Gabrielle de Souza Rocha, Gustavo Sousa Noleto","doi":"10.1055/s-0045-1811173","DOIUrl":"10.1055/s-0045-1811173","url":null,"abstract":"Although it is known that the most commonly used therapies for West syndrome (WS) are intramuscular adrenocorticotropic hormone (ACTH) and oral prednisolone, there is still controversy in the literature regarding the equivalence of their effects.We aimed to present an updated review comparing the therapeutic and adverse effects of ACTH therapy versus corticosteroids in children with West syndrome (WS).The PubMed, EMBASE, and Cochrane Central databases were searched. The outcomes of interest selected were spasm cessation on day 14 of therapy, cessation of hypsarrhythmia and adverse effects such as weight gain, infection, irritability, and hypertension. Studies were reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and a meta-analysis was performed. We compared the results using the risk ratio (RR) and odds ratio (OR). for the binary outcomes, with 95% confidence intervals (CI) and a random-effects model. Statistical analysis was performed using RevMan 5.1.7.Compared with corticoids, ACTH was associated with a significant increase in weight (RR: 1.41; 95% CI: 1.01-1.97; p = 0.04). There was no significant difference in cessation of spasms on day 14 (OR: 0.91; 95% CI: 0.47-1.47; p = 0.79), hypsarrhythmia (OR: 0.97; 95% CI: 0.22-4.34), irritability (RR: 0.78; 95% CI: 0.30-1.99), hypertension (RR: 0.64; 95% CI: 0.35-1.15; p = 0.14), and infection (RR: 0.69; 95% CI: 0.19-2.50; p = 0.57).This study provides robust evidence regarding the safety and efficacy of ACTH or corticoids in children with WS. However, the significant heterogeneity between studies restricts the analysis, emphasizing the need for additional research to assess the best WS treatment option.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 8","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0