Arquivos de neuro-psiquiatria最新文献_第2页

Tenecteplase in acute ischemic stroke: a new era in thrombolysis. 替奈普酶在急性缺血性卒中中的应用：溶栓的新时代。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-06-01 DOI: 10.1055/s-0045-1808088

Gisele Sampaio Silva, Eva Rocha, Octávio Marques Pontes-Neto, Sheila Ouriques Martins

引用次数: 0

Unmasking vertebral artery stump syndrome in recurrent posterior strokes treated with endovascular therapy. 血管内治疗复发性卒中后椎动脉残端综合征的揭露。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-06-01 DOI: 10.1055/s-0045-1806833

Leonardo Furtado Freitas, Kevin J Abrams, Márcio Luís Duarte, Guilherme C Dabus

引用次数: 0

Association among blood pressure, antihypertensive drugs, and amyotrophic lateral sclerosis. 血压、抗高血压药物与肌萎缩性侧索硬化症的关系。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/s-0045-1804922

Zhiguang Li, Yan Li, Jiankai Zhao, Feifei Zhang, Wei Dang, Yanan Jia, Fei Guo, Lixin Guo

{"title":"Association among blood pressure, antihypertensive drugs, and amyotrophic lateral sclerosis.","authors":"Zhiguang Li, Yan Li, Jiankai Zhao, Feifei Zhang, Wei Dang, Yanan Jia, Fei Guo, Lixin Guo","doi":"10.1055/s-0045-1804922","DOIUrl":"https://doi.org/10.1055/s-0045-1804922","url":null,"abstract":"Background: Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease. The impacts of antihypertensive drugs and blood pressure (BP) on ALS are currently debatable.Objective: To evaluate the causal relationship involving antihypertensive drugs, BP, and ALS through a Mendelian randomization (MR) analysis.Methods: The causal relationship between BP and ALS was evaluated by a bidirectional two-sample MR analysis. Then, a sensitivity analysis was performed using a secondary BP genome-wide association study. The drug-target MR was employed to evaluate the impact of antihypertensive drugs on ALS. Furthermore, we used cis-expression quantitative trait loci (cis-eQTLs) data from brain tissue and blood to validate the positive results by a summary-based MR method.Results: We found that an increment in systolic BP (SBP) could elevate the risk of ALS (inverse-variance weighted [IVW] odds ratio [OR] = 1.003; 95% confidence interval [95%CI]: 1.001-1.006; per 10-mmHg increment) and ALS might be protected by angiotensin-converting enzyme inhibitors (ACEIs; OR = 0.970; 95%CI: 0.956-0.984; p = 1.96 × 10-5; per 10-mmHg decrement). A causal relationship was not observed between diastolic BP and other antihypertensive drugs in ALS.Conclusion: In the present study, genetic support for elevated SBP serves as a risk factor for ALS. Besides, ACEIs hold promise as a candidate for ALS.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 5","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giancarlo Comi: a legacy in neurology and multiple sclerosis research. 詹卡洛·科米：神经病学和多发性硬化症研究的遗产。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-04-27 DOI: 10.1055/s-0045-1806830

Maria Fernanda Mendes

引用次数: 0

Genetic and clinical spectrum of early growth response 2-related Charcot-Marie-Tooth disease in a Brazilian cohort. 巴西队列中与早期生长反应2相关的腓骨肌萎缩症的遗传和临床谱

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806820

Eduardo Boiteux Uchôa Cavalcanti, Savana Camilla de Lima Santos, Christian Marques Couto, Galeno Vieira Rocha, Maria Cristina Del Negro Barroso Freitas, Osvaldo José Moreira do Nascimento

{"title":"Genetic and clinical spectrum of early growth response 2-related Charcot-Marie-Tooth disease in a Brazilian cohort.","authors":"Eduardo Boiteux Uchôa Cavalcanti, Savana Camilla de Lima Santos, Christian Marques Couto, Galeno Vieira Rocha, Maria Cristina Del Negro Barroso Freitas, Osvaldo José Moreira do Nascimento","doi":"10.1055/s-0045-1806820","DOIUrl":"https://doi.org/10.1055/s-0045-1806820","url":null,"abstract":"Background: Charcot-Marie-Tooth (CMT) disease is a genetically diverse group of hereditary neuropathies. Most studies on the frequency of CMT subtypes report that the early growth response 2 (EGR2) gene accounts for less than 1% of cases. However, data regarding the epidemiology and clinical characteristics of EGR2-related CMT in Central and South America remain limited.Objective: To characterize the clinical and genetic features of EGR2-related CMT in a Brazilian cohort.Methods: We retrospectively analyzed clinical and ancillary data from four individuals with confirmed molecular diagnosis of EGR2-related CMT. Patients were categorized based on age of onset, motor nerve conduction velocity of the ulnar nerve, and nerve biopsy findings when available. Next-generation sequencing was utilized for genetic analysis.Results: Pathogenic and likely pathogenic variants were identified exclusively in the three zinc-finger domains of EGR2, including a novel variant, c.1234G > C (p.Glu412Gln). Patients exhibited significant variation in clinical severity and phenotypes. Dysphagia, respiratory complications, and scoliosis were prominent features.Conclusion: Our findings corroborate the complex and varied clinical presentations of EGR2-related CMT, highlighting respiratory issues and dysphagia as significant features. Comprehensive clinical assessment and early genetic diagnosis are essential for managing this condition's diverse phenotypic spectrum.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics. 左旋多巴引起的运动障碍仍然是巴西运动障碍诊所的一个主要临床问题。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-20 DOI: 10.1055/s-0045-1806922

Vitor Tumas, Manuelina Mariana Capellari Macruz Brito, Vanderci Borges, Henrique Ballalai Ferraz, Cyrus P Zabetian, Ignacio F Mata, Bruno Lopes Santos-Lobato

{"title":"Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics.","authors":"Vitor Tumas, Manuelina Mariana Capellari Macruz Brito, Vanderci Borges, Henrique Ballalai Ferraz, Cyrus P Zabetian, Ignacio F Mata, Bruno Lopes Santos-Lobato","doi":"10.1055/s-0045-1806922","DOIUrl":"10.1055/s-0045-1806922","url":null,"abstract":"Levodopa-induced dyskinesia (LID) remains a significant motor complication in Parkinson's disease (PD), although opinions differ on its clinical relevance.To explore the current prevalence and impact of LID, we analyzed two cohorts from the Latin American Research Consortium on the Genetics of Parkinson's Disease from movement disorder clinics in the city of São Paulo, Brazil, recruited 10 years apart.The cohorts included 187 individuals diagnosed with PD in phase 1 (2007-2014) and 224 in phase 2 (2021-2022). The presence and functional impact of LID were measured using part IV (items 4.1 and 4.2 respectively) of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).The analysis revealed that LID frequency increased from 34.7 in phase 1 to 54.9% in phase 2 (more recent), with functional impact rising from 25.1 to 38.8%.The findings suggest that LID remains a relevant clinical issue in clinics specialized in movement disorders in Brazil, with no reduction in prevalence throughout the last decade. Further studies from other regions and less specialized neurology centers may help understand this motor complication in Brazil and in other developing countries.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of myasthenia gravis is increased in inflammatory bowel disease. 重症肌无力的患病率在炎症性肠病中增加。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-13 DOI: 10.1055/s-0045-1807717

Antônio Miguel Furtado Leitão, Florian P Thomas, Marcellus Henrique Loiola Ponte de Souza, Lúcia Libanez Bessa Campelo Braga, Francisco de Assis Aquino Gondim

{"title":"The prevalence of myasthenia gravis is increased in inflammatory bowel disease.","authors":"Antônio Miguel Furtado Leitão, Florian P Thomas, Marcellus Henrique Loiola Ponte de Souza, Lúcia Libanez Bessa Campelo Braga, Francisco de Assis Aquino Gondim","doi":"10.1055/s-0045-1807717","DOIUrl":"10.1055/s-0045-1807717","url":null,"abstract":"Comorbid autoimmune disorders affect approximately 0.2% of the population. A second autoimmune disease occurs in up to 15% of myasthenia gravis (MG) patients.To evaluate the association between MG and inflammatory bowel disease (IBD).We conducted a cross-sectional study involving a Brazilian cohort of IBD patients and a literature review.In 2022, we found 1 MG patient with ulcerative colitis and 3 with Crohn's disease out of 606 IBD patients (0.66% prevalence). The patient with UC and MG died in April 2024. The mean IBD onset age was 33.5 ± 2.7; patients were 45.8 ± 7.3-years-old at evaluation. Further, 2 patients were acetylcholine receptor antibody positive, 1 was anti-muscle specific kinase positive, and 1 seronegative. Also, 3 had abnormal repetitive nerve stimulation, all had normal nerve conduction studies, abnormal skin wrinkling test, and mild small fiber neuropathy. None had thymoma and/or underwent thymectomy. According to the MG Foundation's classification, one was class V, one IVb, and two IIa. The MG diagnosis was masked by immunotherapy in all. The prevalence ratio of MG in IBD patients versus the proportion of MG among all patients in our center was 8.56 (p < 0.0001, CI = 3.1-23.5). Considering the lowest and highest prevalence of this condition reported in the literature, the ratio is 44.0 (p < 0.0001, CI: 16.3-118.4) and 26.4 (p < 0.0001, CI: 9.8-70.6), respectively.The prevalence of MG is higher in IBD, may include muscle specific kinase positive disease (first report in the literature) and frequently overlaps with other autoimmune conditions and small fiber neuropathy.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A physiotherapy protocol* for stroke patients in acute hospital settings: expert consensus from the Brazilian early stroke rehabilitation task force. 急性住院卒中患者的物理治疗方案*：巴西早期卒中康复工作组的专家共识。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806924

Iara Maso, Gustavo José Luvizutto, Jéssica Mariana de Aquino Miranda, Carla Ferreira do Nascimento, Luana Aparecida Miranda Bonome, Elen Beatriz Pinto, Fabiane Maria Klitzke, Ricardo Machado Souza, Carla Heloisa Cabral Moro, Rodrigo Bazan, Pedro Antonio Pereira de Jesus, Eduardo de Melo Carvalho Rocha, Cesar Minelli, Sheila Ouriques Martins, Jussara Almeida de Oliveira Baggio

{"title":"A physiotherapy protocol* for stroke patients in acute hospital settings: expert consensus from the Brazilian early stroke rehabilitation task force.","authors":"Iara Maso, Gustavo José Luvizutto, Jéssica Mariana de Aquino Miranda, Carla Ferreira do Nascimento, Luana Aparecida Miranda Bonome, Elen Beatriz Pinto, Fabiane Maria Klitzke, Ricardo Machado Souza, Carla Heloisa Cabral Moro, Rodrigo Bazan, Pedro Antonio Pereira de Jesus, Eduardo de Melo Carvalho Rocha, Cesar Minelli, Sheila Ouriques Martins, Jussara Almeida de Oliveira Baggio","doi":"10.1055/s-0045-1806924","DOIUrl":"https://doi.org/10.1055/s-0045-1806924","url":null,"abstract":"The present protocol provides general recommendations based on the best evidence currently available for physiotherapists to use as a guide for the care of stroke patients during hospitalization. The Brazilian Early Stroke Rehabilitation Task Force, comprising physical therapy experts and researchers from different Brazilian states, was organized to develop this care protocol based on a bibliographical survey, including meta-analyses, systematic reviews, clinical trials, and other more recent and relevant scientific publications. Professionals working in stroke units were also included in the task force to ensure the practicality of the protocol in different contexts. This protocol provides guidance on assessment strategies, safety criteria for the mobilization of patients with stroke, recommendations for mobilization and proper positioning, as well as evidence-based practices for treatment during hospitalization, including preventive measures for shoulder pain and shoulder-hand syndrome. The protocol also provides information on the organization of the physiotherapy service at stroke units, guidelines for hospital discharge, and quality indicators for physiotherapy services. We have included detailed activities that can be performed during mobilization in the supplementary material, such as postural control training, sensory and perceptual stimulation, task-oriented training, and activities involving an enriched environment. The protocol was written in a user-friendly format to facilitate its application in different social and cultural contexts, utilizing resources readily available in most clinical settings.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-18"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-mediated insights into clinical and specific autoantibodies in acute and chronic immune-mediated nodo-paranodopathies. 急性和慢性免疫介导的淋巴结副病的临床和特异性自身抗体免疫介导的见解。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-03-19 DOI: 10.1055/s-0045-1805073

Marcus Vinícius Magno Gonçalves, Pedro José Tomaselli, Wilson Marques Junior

引用次数: 0

Pointing the trident in the right direction: recognizing spinal neurosarcoidosis through a specific MRI pattern. 将三叉戟指向正确的方向：通过特定的MRI模式识别脊髓神经结节病。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-13 DOI: 10.1055/s-0045-1807720

Alena Khalil, Kevin J Abrams, Márcio Luís Duarte, Leonardo Furtado Freitas

引用次数: 0