Arquivos de neuro-psiquiatria最新文献_第3页

Impulsiveness levels among patients with medication-overuse headache accompanying chronic migraine or tension-type headache. 药物滥用性头痛伴慢性偏头痛或紧张性头痛患者的冲动水平。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-13 DOI: 10.1055/s-0045-1807716

Ruken Simsekoglu, Nestug Keskin, Tugba Cankay, Sumeyye Cakmak, Temel Tombul

{"title":"Impulsiveness levels among patients with medication-overuse headache accompanying chronic migraine or tension-type headache.","authors":"Ruken Simsekoglu, Nestug Keskin, Tugba Cankay, Sumeyye Cakmak, Temel Tombul","doi":"10.1055/s-0045-1807716","DOIUrl":"https://doi.org/10.1055/s-0045-1807716","url":null,"abstract":"Impulsiveness in primary headaches is not well understood.To analyze impulsiveness in patients with medication-overuse headache (MOH) and either chronic migraines or chronic tension-type headaches (TTHs).This cross-sectional study included 119 participants (96 female) divided into 3 groups: the migraine with MOH (M-O, n = 44, age = 36.6 ± 11.1), the tension-type headache with MOH group (TTH-O, n = 38, age = 42.6 ± 11.8), and the healthy control group (HC, n = 37, age = 36.9 ± 13.1). The Barratt Impulsiveness Scale-11 Short Form (BIS-11 SF), Beck's Depression Inventory (BDI), Beck's Anxiety Inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI) were used to assess impulsiveness, depression, anxiety, and sleep quality, respectively.Impulsiveness levels were significantly higher in the M-O (p < 0.01) and TTH-O (p < 0.01) groups compared with the HC. However, no significant difference in impulsiveness was found between the M-O and TTH-O (p > 0.05). The PSQI scores were significantly higher in the M-O and TTH-O compared with the HC (p < 0.01). Additionally, anxiety scores were notably higher in the M-O compared with both the TTH-O and HC (p < 0.01).The present study, which compared the M-O and TTH-O groups with HC in terms of impulsiveness, with no significant differences in parameters such as age, gender, schooling, frequency of headache attacks, and disease onset duration, concluded that both patient groups exhibited higher impulsiveness compared with the controls. Furthermore, the lack of difference in impulsiveness between MO and chronic TTH-O patients with a common denominator of MOH suggests that it may be associated with MOH, which is a shared subset of two distinct headache disorders.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EGR2 gene mutations: lessons learned from 4 cases. 4例EGR2基因突变的经验教训。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-26 DOI: 10.1055/s-0045-1809331

Wilson Marques

引用次数: 0

Efficacy and safety of glucagon-like peptide 1 agonists for Parkinson's disease: a systematic review and meta-analysis. 胰高血糖素样肽1激动剂治疗帕金森病的疗效和安全性：系统综述和荟萃分析

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-04-27 DOI: 10.1055/s-0045-1806824

Luis O S Nogueira, Roberto A S V Mazetto, Maria L R Defante, Vânio L J Antunes, Ocílio Ribeiro Gonçalves, Angela Maria Sandini Corso, Marcus V Della Coletta, Dayany Leonel Boone, Walderico Silva Machado Filho, Vanderci Borges, Henrique Ballalai Ferraz

{"title":"Efficacy and safety of glucagon-like peptide 1 agonists for Parkinson's disease: a systematic review and meta-analysis.","authors":"Luis O S Nogueira, Roberto A S V Mazetto, Maria L R Defante, Vânio L J Antunes, Ocílio Ribeiro Gonçalves, Angela Maria Sandini Corso, Marcus V Della Coletta, Dayany Leonel Boone, Walderico Silva Machado Filho, Vanderci Borges, Henrique Ballalai Ferraz","doi":"10.1055/s-0045-1806824","DOIUrl":"https://doi.org/10.1055/s-0045-1806824","url":null,"abstract":"Background: Recent research on Parkinson's disease (PD) therapy has highlighted glucagon-like peptide 1 (GLP-1) agonists as potential therapeutic agents. However, recent randomized controlled trials (RCTs) have shown mixed results regarding the use of this medication.Objective: To perform a meta-analysis comparing GLP-1 agonists with placebo or standard PD treatment in adult PD patients.Methods: We systematically searched the PubMed, Embase and Cochrane Central databases. The efficacy outcomes were assessed through the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) and the 39-item Parkinson's Disease Questionnaire (PDQ-39). We also assessed adverse events. Dichotomous data were compared using the risk ratio (RR), and continuous endpoints were pooled using the mean difference (MD).Results: We included 4 RCTs, with a total of 514 patients. In every study, the Hoehn and Yahr stage was < 3. The pooled analysis demonstrated that the use of GLP-1 agonists was not associated with an improvement in the scores on parts I, II, III, and IV of the MDS-UPDRS at 6 and 12 months of follow-up. Neither did quality of life (PDQ-39) show significant differences among the groups, and a higher risk of gastrointestinal adverse events and weight loss was observed with the use of GLP-1 agonists. A subgroup analysis further confirmed the lack of clinical benefits of the intervention regarding all of these efficacy outcomes, and the intervention also significantly reduced result heterogeneity.Conclusion: In 1 year, GLP-1 agonists failed to improve motor and non-motor features of PD. Additional high-quality studies are needed to draw more robust conclusions about this treatment.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-10"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brás Cubas, Quincas Borba, and Rubião: portraits of neuropsychiatry in the novels of Machado de Assis. Brás古巴、昆卡斯·博尔巴和鲁比<e:1>奥：马查多·德·阿西斯小说中的神经精神病学肖像。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-04-27 DOI: 10.1055/s-0045-1806828

Juliana de Castro Vilanova, Antonione Santos Bezerra Pinto, Giuliano da Paz Oliveira

{"title":"Brás Cubas, Quincas Borba, and Rubião: portraits of neuropsychiatry in the novels of Machado de Assis.","authors":"Juliana de Castro Vilanova, Antonione Santos Bezerra Pinto, Giuliano da Paz Oliveira","doi":"10.1055/s-0045-1806828","DOIUrl":"https://doi.org/10.1055/s-0045-1806828","url":null,"abstract":"The intersection of literature and neuroscience provides a fascinating way to explore human behavior through fictional narratives. Brazilian literature, particularly the work of Machado de Assis, excels in portraying characters with neuropsychiatric conditions. This work aims to establish connections between the fictional representations of human behavior in Machado's classic works and neurological conditions described by contemporary neuroscience. In The Posthumous Memoirs of Brás Cubas and Quincas Borba, Machado's characters exhibit behaviors that align with modern neurological diagnoses. For example, Brás Cubas experiences episodes resembling delirium, characterized by mental confusion and altered cognition, while Quincas Borba shows traits of attention deficit hyperactivity disorder (ADHD) and bipolar disorder. Rubião, the protagonist of Quincas Borba, meets certain criteria for dementia, displaying visual hallucinations and cognitive fluctuations. By analyzing Machado's characters through a neuropsychiatric lens, we can appreciate his remarkable ability to depict complex mental conditions, many of which were not fully understood by medicine at the time.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxford Cognitive Screen - Brazilian Portuguese version (OCS-Br): assessment of vascular cognitive impairment. 牛津认知屏幕-巴西葡萄牙语版（OCS-Br）：血管认知障碍的评估。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-20 DOI: 10.1055/s-0045-1806919

Claudia Cristina Ferreira Ramos, Marcelo Vilela Machado João, Caroline Suemi Ogusuku, Sonia Maria Dozzi Brucki

{"title":"Oxford Cognitive Screen - Brazilian Portuguese version (OCS-Br): assessment of vascular cognitive impairment.","authors":"Claudia Cristina Ferreira Ramos, Marcelo Vilela Machado João, Caroline Suemi Ogusuku, Sonia Maria Dozzi Brucki","doi":"10.1055/s-0045-1806919","DOIUrl":"10.1055/s-0045-1806919","url":null,"abstract":"Cognitive impairment is prevalent in stroke patients and is rarely diagnosed. Cognitive deficits involving language functions, praxis, visuospatial and visuoconstructive skills, as well as memory, are prominent. The cognitive assessment tests available do not address some specific characteristics of stroke patients and present essential limitations concerning the most compromised cognitive domains.To determine the performance profile of the Oxford Cognitive Screen - Brazilian Portuguese version (OCS-Br) in cognitively-healthy individuals and to evaluate its ability to screen for cognitive impairment in individuals after ischemic stroke.We conducted an observational and descriptive study with cognitively-healthy individuals and patients with a history of stroke. The healthy individuals were recruited at the Neurology Clinic of the Outpatient Center of Universidade de São Caetano do Sul and the João Castaldelli Integrated Center for Health and Education for the Elderly, in the city of São Caetano do Sul, state of São Paulo. The stroke patients were recruited at the same Neurology Clinic and among subjects referred from Hospital Municipal de Emergências Albert Sabin and admitted to the Stroke Unit of Hospital Santa Marcelina, in the city of São Paulo, from September 2021 to July 2023.The study included 108 participants, 50 (46.3%) in the stroke group and 58 (53.7%) in the healthy group. When comparing the OCS-Br scores between the groups, we found a significant difference in writing tasks, executive functions (attention, change of strategy), and memory.Our results show the need for adequate monitoring and rehabilitation of poststroke patients. The advantages of the OCS-Br are: its focus on specific cognitive aspects of stroke, such as visual inattention and visual field testing; the assessment of patients with aphasia and visual impairment; and its prognostic value to predict long-term functioning.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic performance of the Brief Cognitive Screening Battery-Indonesian version in detecting cognitive impairment. 简易认知筛查电池-印尼版在检测认知障碍中的诊断性能。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-06-01 DOI: 10.1055/s-0045-1809335

Fasihah Irfani Fitri, Dina Nazriani, Octaviasari Agatha Dachi, Ricardo Nitrini, Paulo Caramelli

{"title":"Diagnostic performance of the Brief Cognitive Screening Battery-Indonesian version in detecting cognitive impairment.","authors":"Fasihah Irfani Fitri, Dina Nazriani, Octaviasari Agatha Dachi, Ricardo Nitrini, Paulo Caramelli","doi":"10.1055/s-0045-1809335","DOIUrl":"https://doi.org/10.1055/s-0045-1809335","url":null,"abstract":"Neuropsychological and functional assessments are crucial for identifying the transition from healthy aging to dementia. While brief cognitive batteries have become popular for their practicality, most have been developed in high-income countries, neglecting the diverse educational backgrounds found in developing nations.This study focuses on the Brief Cognitive Screening Battery (BCSB) adapted for Indonesia (BCSB-INA), aiming to investigate its diagnostic accuracy in detecting cognitive impairment among older adults.This cross-sectional study was conducted at the Memory Clinic of Universitas Sumatera Utara Hospital from January to August 2024, including participants aged 50 and above. Subjects underwent cognitive assessments using MoCA-INA and BCSB-INA. Data analysis involved ROC curves to evaluate the tests' accuracy.A total of 140 subjects were included, with significant differences in cognitive test scores between those with cognitive impairment and normal individuals. The BCSB-INA demonstrated good diagnostic performance, with an AUC of 0.875 when including the Clock Drawing Test (CDT) and 0.810 without it. The development of a multivariate model further enhances its diagnostic capabilities, allowing for more tailored intervention strategies.The BCSB-INA represents an important improvement in cognitive assessment for older adults in Indonesia, showing good sensitivity and specificity. Continued research and updates to cognitive assessment tools are crucial to meet the increasing demand for effective dementia screening in diverse populations.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A decade of whole-exome sequencing in Brazilian Neurology: from past insights to future perspectives. 巴西神经病学的十年全外显子组测序：从过去的见解到未来的观点。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-13 DOI: 10.1055/s-0045-1807715

Caio Robledo D'Angioli Costa Quaio, Thiago Yoshinaga Tonholo Silva, Orlando G Barsottini, Sarah Teixeira Camargos, Marcondes C França, Jonas A Saute, Wilson Marques, Fernando Kok, José Luiz Pedroso

{"title":"A decade of whole-exome sequencing in Brazilian Neurology: from past insights to future perspectives.","authors":"Caio Robledo D'Angioli Costa Quaio, Thiago Yoshinaga Tonholo Silva, Orlando G Barsottini, Sarah Teixeira Camargos, Marcondes C França, Jonas A Saute, Wilson Marques, Fernando Kok, José Luiz Pedroso","doi":"10.1055/s-0045-1807715","DOIUrl":"https://doi.org/10.1055/s-0045-1807715","url":null,"abstract":"Over the last decade, whole-exome sequencing (WES) has become a standard diagnostic tool, significantly transforming the landscape of clinical genetics and playing a pivotal role in the diagnosis of neurogenetic diseases. This revolutionary shift has left a lasting impact on the field of neurology in Brazil. The current review article examines key developments and milestones achieved in Brazil through the application of WES in neurology and discusses forthcoming challenges and essential steps to advance molecular diagnosis. Several studies report the use of WES to diagnose genetic disorders with neurological manifestations in Brazil, underscoring the growing importance of molecular diagnosis in neurogenetics. These studies often provide detailed phenotypic analyses and clinical descriptions, offering valuable insights into the genetic underpinnings of several neurological conditions. Many reports highlight the use of WES in the investigation of complex neurological conditions in Brazil, such as neurodevelopmental disorders, hereditary spastic paraplegia, movement disorders, and ataxia. The discovery of new genes implicated in monogenic diseases with neurological manifestations through WES was a significant breakthrough. Despite these advances, the availability of large cohort studies on rare diseases in Brazil remains limited, hindering the ability to generalize findings and explore the full spectrum of genetic diversity. However, a few larger cohort studies have substantially contributed to our understanding of rare diseases and specific neurological disorders.While WES has limitations and may eventually be supplanted by more advanced diagnostic tools, it left a permanent mark on the neurology field in Brazil. The field of neurogenetics is set to become increasingly important in the future.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-14"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing female sexual dysfunction in patients with relapsing-remitting multiple sclerosis. 评估复发缓解型多发性硬化症患者的女性性功能障碍。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806819

Elisa Matias Vieira de Melo, Flavia Fairbanks Lima de Oliveira Ruano, Maria Fernanda Mendes, Guilherme Sciascia do Olival

{"title":"Assessing female sexual dysfunction in patients with relapsing-remitting multiple sclerosis.","authors":"Elisa Matias Vieira de Melo, Flavia Fairbanks Lima de Oliveira Ruano, Maria Fernanda Mendes, Guilherme Sciascia do Olival","doi":"10.1055/s-0045-1806819","DOIUrl":"10.1055/s-0045-1806819","url":null,"abstract":"Background: Multiple sclerosis (MS) affects mainly young people of reproductive age with significant lifelong repercussions, among which sexual dysfunction (SD) is one of the most neglected during routine clinical care.Objective: To evaluate SD in female patients diagnosed with relapsing-remitting MS (RRMS).Methods: This cross-sectional analytic study was performed at the Santa Casa de São Paulo Hospital, Faculdade de Ciências Médicas, São Paulo, Brazil, between November 2020 and March 2022. The sample included 80 female patients diagnosed with RRMS and 106 healthy controls. Questionnaires probing sexual dysfunction (the Multiple Sclerosis Intimacy and Sexuality Questionnaire - MSISQ-19 and the Female Sexual Function Index - FSFI) and depression and anxiety (the Hospital Anxiety and Depression Scale - HADS, the Beck Depression Inventory - BDI; and the Beck Anxiety Inventory - BAI) were applied.Results: A high prevalence of SD in both groups (43.4% and 38.8% for the RRMS and control groups, respectively) was identified by the FSFI analysis. A statistically higher prevalence (56.3%) of sexual dysfunction was detected in RRMS patients when using the MSISQ-19 tool to assess sexuality in this population compared with the FSFI scale (p = 0.016).Conclusion: A high prevalence of SD was found in both MS patients and healthy controls as measured by the FSFI. However, the specific tool (MSISQ-19) revealed a higher prevalence of SD in MS patients. Thus, the use of MSISQ-19 for the diagnosis and management of SD in this patient group is recommended.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 4","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Before executive dysfunction is attributed to fibromyalgia, other causes must be thoroughly ruled out. 在将执行功能障碍归因于纤维肌痛之前，必须彻底排除其他原因。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-04-01 Epub Date: 2025-05-26 DOI: 10.1055/s-0045-1805074

Josef Finsterer

引用次数: 0

Addressing pediatric traumatic brain injury in Brazil: a call for targeted prevention. 解决巴西儿童创伤性脑损伤：呼吁有针对性的预防。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806814

Gisele Sampaio Silva

引用次数: 0