Arquivos de neuro-psiquiatria最新文献

{"title":"The effect of technology use on sleep quality in primary school-aged children.","authors":"Feyza Dereli, Merve Ercan","doi":"10.1055/s-0046-1827211","DOIUrl":"10.1055/s-0046-1827211","url":null,"abstract":"<p><strong>Background: </strong>Childhood sleep problems are an increasing public health concern. Although screen-based technology use is a potential cause, the specific effects of distinct screen-based behaviors on children's sleep remain unclear.</p><p><strong>Objective: </strong>To examine associations between technology use characteristics and sleep quality among primary school-aged children.</p><p><strong>Methods: </strong>The present descriptive and correlational study was conducted based on parent reports from 600 primary school students. Sleep quality was assessed using the Children's Sleep Habits Questionnaire (CSHQ). The following were investigated: sociodemographic variables, television, tablet, and smartphone usage times; the presence of technological devices in the children's rooms; and technology use before bedtime. Group comparisons were made using non-parametric tests, and a multiple linear regression analysis was used to examine the independent predictors of the CSHQ total score.</p><p><strong>Results: </strong>The mean CSAQ score for children was 52.79 ± 6.73, and 98.7% of participants were above the clinical sleep problem threshold. The utilization of technological devices was found to be associated with a substantial effect on sleep quality. The utilization of technology prior to bedtime, in addition to smartphone usage that exceeds 2 hours per day, has been demonstrated to be significantly associated with elevated CSHQ scores. In the multiple regression analysis, it was identified that smartphone use (> 2 hours/day) was the strongest independent predictor of sleep quality (β = 0.34; <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The findings of the present study indicate that smartphone use, particularly before bedtime and for extended periods, has a substantial and adverse effect on the quality of sleep in elementary school children.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional neurological disorder: characterization, diagnosis, and outcome predictors in a Brazilian cohort.","authors":"Lucas D'Andréa, Antonio Asciutti, Jordana Borges Camargo Diniz, Eduardo Genaro Mutarelli, Bruna Bartorelli","doi":"10.1055/s-0046-1827064","DOIUrl":"10.1055/s-0046-1827064","url":null,"abstract":"<p><strong>Background: </strong>Functional neurological disorder (FND) is a prevalent, disabling neuropsychiatric condition recognized as a distinct clinical entity characterized by positive neurological signs. Despite growing international research, Brazilian data on this disoder remain scarce and predictors of clinical outcomes are poorly established.</p><p><strong>Objective: </strong>To describe the clinical profile of patients with FND in a Brazilian outpatient cohort and investigate predictors of functional improvement.</p><p><strong>Methods: </strong>We retrospectively analyzed medical records of 29 patients diagnosed with FND at the Somatic Disorders Outpatient Unit (SOMA) of the Institute of Psychiatry of Hospital das Clínicas, Universidade de São Paulo (IPq-HCFMUSP). Psychiatric diagnoses were established by board-certified psychiatrists using Diagnostic and Statistical Manual of Mental Disorders 5^th edition (DSM-5) criteria and structured clinical interview. Clinical features, psychiatric comorbidities, and therapeutic interventions were recorded. A multivariable Firth's bias-reduced logistic regression identified predictors of functional improvement.</p><p><strong>Results: </strong>The cohort included predominantly cisgender women (75.9%), with a mean age of 33.6 ± 13 years. The most common presentations were pain (51.7%) and paresis (48.3%); others included psychogenic nonepileptic seizures (PNES), sensory disturbances, and speech alterations. The most frequent positive neurological sign was Hoover's sign (20.7%). Psychiatric comorbidities included mood (44.8%), anxiety (20.7%), and personality disorders (10.3%). Overall, 31% achieved functional improvement. Group psychotherapy with a psychodynamic orientation significantly increased odds of improvement (<i>p</i> = 0.036); eutony also showed a positive association (odds ratio [OR] = 5.68; <i>p</i> < 0.05). Absence of mood disorders was associated with lower odds of improvement (OR = 0.36; 95% confidence interval: 0.11-0.99; <i>p</i> = 0.048).</p><p><strong>Conclusion: </strong>The present is the first Brazilian study to employ multivariable modeling to identify predictors of functional outcomes in FND. Group psychotherapy and eutony were associated with improvement, reinforcing the value of multidisciplinary approaches and highlighting the importance of Latin American clinical data.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a self-administered version of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R).","authors":"Thais Alves Cunha, Laura Carvalheira Dourado, Glauciane Costa Santana, Mário Teruo Yanagiura, Leonardo Judson Galvão-Lima, Sancha Helena de Lima Vale, José Brandão-Neto, Mário Emílio Teixeira Dourado-Junior, Lucia Leite-Lais","doi":"10.1055/s-0046-1827063","DOIUrl":"10.1055/s-0046-1827063","url":null,"abstract":"<p><strong>Background: </strong>The Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is a standard tool for evaluating functional decline in patients with ALS. Despite its clinical value, administration by healthcare professionals can be time-consuming and resource intensive.</p><p><strong>Objective: </strong>To assess the reliability and feasibility of a self-administration version of the ALSFRS-R as an alternative for use in clinical and research settings.</p><p><strong>Methods: </strong>The present was an observational, analytical, prospective, single-center study involving ALS patients followed at the Neurology Outpatient Clinic of the Hospital Universitário Onofre Lopes (HUOL). Three independent assessments of the ALSFRS-R were conducted: one self-administered version and two interviewer-administered versions performed by different researchers during face-to-face consultations. Interrater reliability was assessed using intraclass correlation coefficients (ICCs), and agreement among the three versions was analyzed using Bland-Altman plots.</p><p><strong>Results: </strong>A total of 43 participants were included in the study, with a mean age of 57 ± 11.67 years. The ICCs indicated high reliability for both the total ALSFRS-R score and its functional domains. Linear regression analyses demonstrated strong agreement between the two researchers (R² = 0.98, <i>p</i> < 0.001), as well as between each researcher and the self-administered version (R² = 0.90 and 0.88, respectively). Bland-Altman analyses showed minimal bias and acceptable limits of agreement across all comparisons.</p><p><strong>Conclusion: </strong>The self-administered version of the ALSFRS-R demonstrated high reliability and strong agreement with the researcher-administered versions, supporting its potential use for remote monitoring of ALS patients. Nonetheless, it should not replace professional assessments in clinical trial settings. Further research is warranted to validate its applicability in broader clinical contexts and diverse patient populations.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed diagnosis of cluster headache in Portugal.","authors":"Lénia Silva, Tiago Millner, Mariana Cabral, Aurora Costa, Pedro Almeida, Beatriz Barreto, Madalena Pinto, Rafael Dias, Stefanie Moreira, Gonçalo V Bonifácio, Sofia Marinho Pinto, Rita Castro, Ivânia Alves, Ana Luísa Rocha, Sara Varanda, Andreia Costa, Carlos Andrade","doi":"10.1055/s-0046-1827040","DOIUrl":"10.1055/s-0046-1827040","url":null,"abstract":"<p><strong>Background: </strong>Cluster headache (CH) has well-defined diagnostic criteria, but its diagnostic delay (DD) remains substantial, averaging 3.6 to 9 years, leading to inappropriate treatments and significant psychosocial and socioeconomic burdens.</p><p><strong>Objective: </strong>To identify demographic and clinical factors associated with DD in CH to promote earlier diagnosis.</p><p><strong>Methods: </strong>A multicenter cross-sectional study recruited 64 patients with episodic or chronic CH from 6 Portuguese neurology centers. Participants completed an online questionnaire covering demographics, clinical features, prior consultations, diagnoses, and treatments. Diagnostic delay was defined as the time from symptom onset to formal diagnosis. Correlation tests and multiple linear regression were performed to identify predictors of DD.</p><p><strong>Results: </strong>The mean DD was of 6.4 ± 8.3 (range: 0-39) years, with 46.9% experiencing delays > 4 years. No sex differences were observed. Younger age at onset (ρ = -0.45; <i>p</i> < 0.001); attack onset between midnight and 3 am (<i>p</i> = 0.029), and eyelid edema (<i>p</i> = 0.001) were associated with shorter DD. The number of pain episodes before neurology consultation strongly correlated with DD (ρ = 0.92; <i>p</i> < 0.001), underscoring the impact of referral delays. Most patients (59.4%) received alternative diagnoses, mainly migraine and sinusitis. Prior triptan (<i>p</i> = 0.037) and topiramate use (<i>p</i> = 0.012) were linked to longer DD. Multivariate models highlighted age at onset and clinical features as primary predictors, explaining nearly 60% of variance.</p><p><strong>Conclusion: </strong>Diagnostic delay in CH remains considerable in Portugal. Increasing awareness among primary care physicians and non-neurologist specialists is crucial to reduce DD and inappropriate treatments. Further research should clarify the role of educational level and support targeted interventions for timely recognition.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe cytotoxic edema after CAR-T cell therapy for acute lymphoblastic leukemia.","authors":"Victor Rebelo Procaci, Maria Luiza Lacerda, Luis Filipe de Souza Godoy, João Victor Luisi de Moura, Angela Sauter Dalbem, Mariana Nassif Kerbauy, Lucila Nassif Kerbauy","doi":"10.1055/s-0046-1825766","DOIUrl":"10.1055/s-0046-1825766","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-3"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors related to neurological disability after the implementation of the first stroke unit in a remote region of Brazil.","authors":"Ana Rosa Ribeiro Fonseca, Allex Jardim da Fonseca, Lívia Maria da Silva Martins, Caio Cayres de Queiroz, Joab Ferreira de Oliveira Júnior, Ananda de Melo Albuquerque, Kelven Henrique Silva de Sousa, Raquel Gaio de Matos, Gustavo Procópio Silva, Ruan Lucas de Almeida Mangueira, André Machado de Siqueira","doi":"10.1055/s-0046-1827210","DOIUrl":"10.1055/s-0046-1827210","url":null,"abstract":"<p><strong>Background: </strong>Stroke is the main public health problem in Brazil.</p><p><strong>Objective: </strong>To evaluate the incidence of moderate-to-severe disability in patients admitted to the Stroke Unit in Roraima (2024), and estimate the impact of Stroke Unit implementation on neurological outcomes compared with historical data.</p><p><strong>Methods: </strong>This hospital-based observational cohort study assessed factors associated with moderate-to-severe disability in patients admitted to the Stroke Unit. Clinical and sociodemographic data were collected using a semistructured questionnaire. Participants were evaluated daily until discharge or death using the National Institutes of Health stroke scale (NIHSS).</p><p><strong>Results: </strong>A total of 400 patients was included. Mean age was 64.2 ± 15.8 years, and 52% of patients were male. Most cases were of ischemic stroke (82.2%), followed by wake-up stroke (13%), transient ischemic attack (TIA: 10%), and hemorrhagic stroke (1%). Systemic arterial hypertension (SAH: 57.1%), and diabetes (33.1%) were the most frequent comorbidities. Nearly 80% of patients were discharged, and the mortality rate was 3.7%. According to the modified Rankin Scale (mRS), moderate-to-severe disability at day 90 was associated with age > 70 years (RR = 1.45; 95% CI = 1.02-4.53), previous stroke (RR = 1.35; 95% CI = 1.12-3.42), and structural heart disease (RR = 1.80; 95% CI = 1.23-3.28). Thrombolytic therapy was performed in 12.5% of cases and reduced moderate-to-severe sequelae by 50%.</p><p><strong>Conclusion: </strong>Stroke Unit implementation represented a significant advance in stroke care in Roraima, reducing sequelae severity and mortality, including among older patients. However, access to thrombolytic therapy remains limited due to delayed hospital admission.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signs and symptoms in spatial neglect syndrome: a systematic review and meta-analysis.","authors":"Tiago Costa da Silva, Davi Telécio Firmino, Camilla Vanessa Araújo Soares, Adriana M T Nepomuceno, Alex T Meira","doi":"10.1055/s-0046-1827209","DOIUrl":"10.1055/s-0046-1827209","url":null,"abstract":"<p><strong>Background: </strong>Stroke is the second leading cause of mortality in the general population. Spatial neglect syndrome is one of the most common complications following stroke and is associated with poor prognosis, including prolonged hospitalization.</p><p><strong>Objective: </strong>To examine the main clinical signs and symptoms associated with spatial neglect in stroke patients in the literature.</p><p><strong>Methods: </strong>The present systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. The Grading of Recommendations Assessment, Development and Evaluation approach was applied to assess the certainty of evidence, and the data were processed with RevMan Web (The Cochrane Collaboration).</p><p><strong>Results: </strong>A total of 362 articles were assessed, out of which 23 were included. A strong correlation was observed between clinical events and the presence of spatial neglect syndrome compared to control groups (oculomotor exploratory behavior [<i>p</i> < 0.00001; 95% CI 4.03-22.41], difficulty detecting stimuli on the left side (<i>p</i> < 0.0001; 95% CI 3.20-24.89), and prolonged reaction time to left-sided stimuli (<i>p</i> = 0.004; 95% CI 1.11-273.20). The present study confirms that spatial neglect syndrome presents as a clinically diverse condition. The quantitative analysis demonstrated that abnormal oculomotor behavior is the most robust and consistent clinical predictor for diagnosis. Other frequent symptoms included delayed reaction times and impaired detection of stimuli in the left visual field. Additionally, the presence of hemianopia and the crossed legs sign were also associated with spatial neglect syndrome among others.</p><p><strong>Conclusion: </strong>The symptomatology described may serve as an indication of spatial neglect syndrome. Therefore, the present meta-analysis highlights the clinical importance of early identification and targeted evaluation in stroke cases.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and neuromuscular disorders: a comprehensive review.","authors":"Christian Messina","doi":"10.1055/s-0046-1829037","DOIUrl":"10.1055/s-0046-1829037","url":null,"abstract":"<p><strong>Abstract: </strong>Emerging evidence highlights a bidirectional interaction between the gut microbiota (GM) and the neuromuscular system, suggesting that microbial composition and metabolic activity may play a pivotal role in the pathophysiology of several neuromuscular diseases (NMDs). This comprehensive review synthesizes current evidence on GM alterations across a broad spectrum of NMDs, emphasizing their potential implications for disease mechanisms and management. Gut microbial shifts have been consistently associated with immune dysregulation, systemic inflammation, and metabolic disturbances that may contribute to neuromuscular dysfunction. Beyond their pathogenetic relevance, these alterations hold diagnostic and therapeutic promise. Probiotic supplementation, dietary modulation, and other microbiota-targeted strategies have shown preliminary benefits in alleviating symptoms and improving metabolic balance in selected NMDs, although existing studies remain limited and heterogeneous. This review offers an integrative perspective, positioning the GM not only as a potential biomarker for diagnosis and disease monitoring but also as a novel therapeutic target. A deeper understanding of the gut-muscle-nerve axis could pave the way for more personalized and mechanism-based approaches in neuromuscular medicine, particularly for disorders where disease-modifying treatments are still lacking. Further well-designed, longitudinal, and mechanistic studies are warranted to elucidate causal relationships and translate microbiome research into clinical application.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and comprehensive validation of the Neurological Outcome Scale for Traumatic Brain Injury (NOS-TBI) into Brazilian Portuguese.","authors":"Karina T Weber, Luciana B M Alves, Monica C Braga, Suleimy C Mazin, Brunna R Pileggi, Millene R Camilo, Viviane A Guimaraes, Clara M A Barreira, Frederico Alessio-Alves, Aline S Carvalho, Aline C Pacheco-Castilho, João P Leite, Dylan J Edwards, Octavio M Pontes-Neto, Taiza G S Edwards","doi":"10.1055/s-0046-1829021","DOIUrl":"10.1055/s-0046-1829021","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a leading cause of disability in Brazil and worldwide. National and multinational clinical trials in TBI require global standardization of outcome measures. The original English version of the Neurological Outcome Scale for TBI (NOS-TBI) is a valid and valuable neurological assessment tool. However, NOS-TBI has not yet been validated in Brazilian Portuguese.</p><p><strong>Objective: </strong>To perform the translation, cultural adaptation, and validation of the NOS-TBI in a Brazilian cohort of individuals with TBI.</p><p><strong>Methods: </strong>We conducted the translation and cultural adaptation of the NOS-TBI scale to Brazilian Portuguese, followed by an analysis of psychometric properties: internal consistency; interrater reliability; concurrent validity in relation to Revised Trauma Score (RTS) and Glasgow Coma Scale (GCS); and convergent validity in relation to Functional Independence Measure (FIM), and Extended Glasgow Outcome Scale (GOS-E). We assessed 255 subjects with TBI, age 42 ± 17.9 years, male-to-female ratio of 4.2:1. The interrater reliability analysis was conducted in a subcohort of 136 subjects, 85.3% male, aged 40.3 ± 17.5 years.</p><p><strong>Results: </strong>The Brazilian Portuguese NOS-TBI showed excellent consistency and interrater reliability. The intraclass correlation coefficient (ICC) revealed excellent interrater agreement. The concurrent validity showed strong correlations of the NOS-TBI with both GCS and RTS at admission. For convergent validity, moderate correlations were observed for both GOS-E and FIM.</p><p><strong>Conclusion: </strong>The Brazilian Portuguese NOS-TBI is valid, reliable, and can be used in clinical practice and scientific studies. Globally, developing relevant and reliable clinical scales in different languages, such as the NOS-TBI, can facilitate multinational studies in the field.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 9","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antônio Austregésilo Rodrigues de Lima (1876-1960) on his 150th anniversary: the polymath of Brazilian neurology.","authors":"Marleide da Mota Gomes, Marcos Raimundo Gomes de Freitas","doi":"10.1055/s-0046-1827167","DOIUrl":"10.1055/s-0046-1827167","url":null,"abstract":"<p><strong>Abstract: </strong>The present study reexamines the enduring impact of Antônio Austregésilo Rodrigues de Lima (1876-1960), a pioneer who shaped Brazil's medical landscape. Austregésilo did not just introduce European medical traditions-particularly those of Jean-Martin Charcot and Emil Kraepelin-to Brazil; he reimagined them to address the country's unique struggles with infectious diseases, weak institutions, and rapid social change. His work spanned clinical practice, political advocacy, literature, and education, revealing a career defined by innovation and a relentless drive to professionalize medicine. Yet, Austregésilo's legacy is not without its contradictions. While he helped legitimize neurology in Brazil, his contributions also reflect the ethical, social, and gender biases of his time. This paper argues that his story is ultimately one of creative adaptation-a testament to how global medical knowledge is reshaped within the realities of a postcolonial society.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}