Arquivos de neuro-psiquiatria最新文献

{"title":"Relationship between food triggers and sensory hypersensitivity in patients with migraine.","authors":"Aline Vitali-Silva, Valéria Aparecida Bello, Regina Célia Poli-Frederico, Carlos Eduardo Coral de Oliveira, Edna Maria Vissoci Reiche, Beatriz Bagatim Bossa, Debora Villas Boas Rezende, Bárbara Ferreira Khouri, Raimundo Pereira Silva-Néto","doi":"10.1055/s-0044-1793934","DOIUrl":"https://doi.org/10.1055/s-0044-1793934","url":null,"abstract":"<p><strong>Background: </strong> The recognition of food as the trigger of attacks occurs in approximately 25% of individuals with migraine. However, differentiating migraine food triggers and prodrome symptoms is still a challenge.</p><p><strong>Objective: </strong> To understand the association of clinical characteristics of migraine with food triggers and to identify predictors of food triggers.</p><p><strong>Methods: </strong> Patients with migraine diagnosed according to the criteria of the third edition of the International Classification of Headache Disorders (ICHD-3) were evaluated for the presence or absence of food triggers.</p><p><strong>Results: </strong> In total, 502 patients with migraine were investigated, and they were divided into two groups: those with food triggers (58.4%) and those without food triggers (41.6%). The main food triggers were alcohol (44%), chocolate (42%), cheese (27.7%), excess carbohydrates (27.7%), coffee (21.8%), cold cuts (16%), and citrus fruits (11.9%). Aura and excessive use of analgesics were more frequent among patients with food triggers (<i>p</i> = 0.022). Photophobia and osmophobia were associated with the presence of a food trigger (<i>p</i> < 0.001). There was a greater impact of migraine in the presence of food triggers (<i>p</i> = 0.002). Through binary logistic regression, we identified clinical predictors of food triggers, such as photophobia and osmophobia.</p><p><strong>Conclusion: </strong> The presence of a food trigger was significantly associated with photophobia and osmophobia. Osmophobia might be another mechanism by which patients perceive foods as triggers for their migraine attacks.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 11","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability in chronic ischemic stroke: analysis during the sleep-wake cycle.","authors":"Natalia Buitrago-Ricaurte, Fatima Dumas Cintra, Jean Faber, Gisele Sampaio Silva","doi":"10.1055/s-0044-1791660","DOIUrl":"10.1055/s-0044-1791660","url":null,"abstract":"<p><strong>Background: </strong> Alterations of the autonomic nervous system (ANS) in the chronic stage of ischemic stroke (IS) are not well understood. Heart rate variability (HRV) provides a noninvasive approach to assess autonomic function.</p><p><strong>Objective: </strong> To compare the HRV parameters during the sleep-wake cycle between patients with IS in the chronic stage and healthy subjects.</p><p><strong>Methods: </strong> We conducted a retrospective transversal study based on clinical records and 24-hour electrocardiogram (EKG) monitoring registries of 179 patients with a confirmed IS diagnosis and 184 age- and sex-matched healthy subjects. Circadian variation was calculated according to the variation of the total autonomic activity (VTAI) and the parasympathetic activity (VPAI) indexes. Comparisons were performed using nonparametric tests. Multivariable analyses were performed with canonical discriminant analysis (CDA) and a three-way analysis of variance (ANOVA). Statistical significance was established with a confidence level of 95%.</p><p><strong>Results: </strong> During waking hours, the healthy group exhibited higher variability in the time domain and frequency domain parameters: standard deviation of NN intervals (SDNN, <i>p</i> < 0.001) and of the average NN intervals (SDANN, <i>p</i> < 0.001), as well as low-frequency (LF) band (<i>p</i> < 0.001). During sleep, the difference was higher in the high-frequency (HF) band (<i>p</i> < 0.001), and lower in the low-/high-frequency ratio (LF/HF, <i>p</i> < 0.001). Both VPAI and VTAI showed less significant difference in IS patients (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong> There was diminished heart vagal activity among IS patients, as measured through HRV. During sleep, this is likely caused by an imbalance in the sympathetic and parasympathetic systems shifting through the sleep phases. These imbalances could persist over time in patients with IS, lasting months after the initial injury.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 11","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type-1 spinal muscular atrophy cohort before and after disease-modifying therapies.","authors":"Brenda Klemm Arci Mattos de Freitas Alves, Alexandra Prufer de Queiroz Campos Araujo, Flávia Nardes Dos Santos, Márcia Gonçalves Ribeiro","doi":"10.1055/s-0044-1791757","DOIUrl":"10.1055/s-0044-1791757","url":null,"abstract":"<p><strong>Background: </strong> Spinal muscular atrophy (SMA-5q) is a neurodegenerative disease characterized by progressive muscle atrophy, hypotonia, and weakness, with SMA 1 presenting symptoms within the first 6 months of life. Disease-modifying therapies have been approved, with better outcomes with earlier treatment.</p><p><strong>Objective: </strong> To describe the safety and clinical efficacy of disease-modifying therapies based on <i>SMN1</i> and <i>SMN2</i> gene strategies concerning motor, respiratory, and bulbar function. Patients with SMA 1 were divided into 2 groups: those exclusively on nusinersen (group 1) and those transitioning to onasemnogene abeparvovec (OA) (group 2).</p><p><strong>Methods: </strong> Over 18 months, patients were assessed using the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) scale, developmental milestones, ventilation needs and duration, nutritional support needs, consistency of food, and signs of dysphagia. There were ten patients, divided between the groups; in group 1, the average age for starting nusinersen was 53.6 (12-115) months, and, in group 2, the age was 7 (1-12) months for nusinersen and 15.2 (10-19) months for OA.</p><p><strong>Results: </strong> Our results indicate that 70% of patients reached some motor milestones, with group 1 increasing by 10.2 points on the CHOP-INTEND scale, while group 2 increased by 33 points. Additionally, 90% of the patients experienced no respiratory decline, and 30% maintained oral feeding. No serious adverse effects or deaths were recorded.</p><p><strong>Conclusion: </strong> Both groups showed improvement in motor function and stabilization of respiratory and bulbar function, with the difference between the groups possibly being related to the earlier treatment initiation. Thus, the present study provides valuable insights into the real-world safety and clinical efficacy of disease-modifying therapies for SMA 1 patients.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 11","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of disease-modifying therapies in SMA-5q type 1 and the importance of early diagnosis of the disease.","authors":"Edmar Zanoteli","doi":"10.1055/s-0044-1800927","DOIUrl":"https://doi.org/10.1055/s-0044-1800927","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 11","pages":"1-2"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone graft migration into the spinal canal after endoscopic lumbar interbody fusion: a rare postoperative complication.","authors":"Isaac C Slagel, Mohammed Sabawi, Leonardo Furtado Freitas","doi":"10.1055/s-0044-1793911","DOIUrl":"https://doi.org/10.1055/s-0044-1793911","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 11","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial doppler ultrasonography in neurocysticercosis.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1055/s-0044-1792017","DOIUrl":"https://doi.org/10.1055/s-0044-1792017","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 10","pages":"1"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused neurological assessment to differentiate essential tremor from functional tremor.","authors":"Thiago Trajano da Silva, Igor Vilela Brum, Isadora Santos Ferreira, Jacy Bezerra Parmera","doi":"10.1055/s-0044-1788267","DOIUrl":"10.1055/s-0044-1788267","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 10","pages":"1-2"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why should a 5q spinal muscular atrophy neonatal screening program be started?","authors":"Michele Michelin Becker, Flávia Nardes, Tamara Dangouloff, Laurent Servais, Alexandra Prufer de Queiroz Campos Araujo, Juliana Gurgel-Giannetti","doi":"10.1055/s-0044-1791201","DOIUrl":"10.1055/s-0044-1791201","url":null,"abstract":"<p><p>Spinal muscular atrophy (SMA) is a genetic neuromuscular progressive disorder that is currently treatable. The sooner the disease-modifying therapies are started, the better the prognosis. Newborn screening for SMA, which is already performed in many countries, has been scheduled to begin in the near future. The development of a well-organized program is paramount to achieve favorable outcomes for the child who is born with the disease and for the costs involved in health care. We herein present a review paper hoping to point out that SMA neonatal screening is urgent and will not increase the cost of its care.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 10","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A predictive score for atrial fibrillation in poststroke patients.","authors":"Caroliny Trevisan Teixeira, Vanessa Rizelio, Alexandre Robles, Levi Coelho Maia Barros, Gisele Sampaio Silva, João Brainer Clares de Andrade","doi":"10.1055/s-0044-1788271","DOIUrl":"10.1055/s-0044-1788271","url":null,"abstract":"<p><strong>Background: </strong> Atrial fibrillation (AF) is a risk factor for cerebral ischemia. Identifying the presence of AF, especially in paroxysmal cases, may take time and lacks clear support in the literature regarding the optimal investigative approach; in resource-limited settings, identifying a higher-risk group for AF can assist in planning further investigation.</p><p><strong>Objective: </strong> To develop a scoring tool to predict the risk of incident AF in the poststroke follow-up.</p><p><strong>Methods: </strong> A retrospective longitudinal study with data collected from electronic medical records of patients hospitalized and followed up for cerebral ischemia from 2014 to 2021 at a tertiary stroke center. Demographic, clinical, laboratory, electrocardiogram, and echocardiogram data, as well as neuroimaging data, were collected. Stepwise logistic regression was employed to identify associated variables. A score with integer numbers was created based on beta coefficients. Calibration and validation were performed to evaluate accuracy.</p><p><strong>Results: </strong> We included 872 patients in the final analysis. The score was created with left atrial diameter ≥ 42 mm (2 points), age ≥ 70 years (1 point), presence of septal aneurysm (2 points), and score ≥ 6 points at admission on the National Institutes of Health Stroke Scale (NIHSS; 1 point). The score ranges from 0 to 6. Patients with a score ≥ 2 points had a fivefold increased risk of having AF detected in the follow-up. The area under the curve (AUC) was of 0.77 (0.72-0.85).</p><p><strong>Conclusion: </strong> We were able structure an accurate risk score tool for incident AF, which could be validated in multicenter samples in future studies.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 10","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absolute beta power in exercisers and nonexercisers in preparation for the oddball task.","authors":"Marcos Machado, Renato Fonseca, Giovanna Zanchetta, Carlos Amoroso, Alexandre Vasconcelos, Élida Costa, Eduardo Nicoliche, Mariana Gongora, Marco Orsini, Renan Vicente, Silmar Teixeira, Henning Budde, Mauricio Cagy, Bruna Velasques, Pedro Ribeiro","doi":"10.1055/s-0044-1791518","DOIUrl":"10.1055/s-0044-1791518","url":null,"abstract":"<p><strong>Background: </strong> High levels of physical conditioning are associated with improvements in cognitive performance. In this sense, electroencephalographic (ECG) correlates are used to investigate the enhancing role of physical exercise on executive functions. Oscillations in the β frequency range are proposed to be evident during sensorimotor activity.</p><p><strong>Objective: </strong> To investigate the ECG changes influenced by aerobic and resistance exercises performed in an attention task by analyzing the differences in absolute β power in the prefrontal and frontal regions before, during, and after the oddball paradigm in practitioners and nonpractitioners of physical exercise.</p><p><strong>Methods: </strong> There were 15 physical activity practitioners (aged 27 ± 4.71) and 15 nonpractitioners (age 28 ± 1.50) recruited. A two-way analysis of variance (ANOVA) was implemented to observe the main effect and the interaction between groups and moments (rest 1, pre-stimulus, and rest 2).</p><p><strong>Results: </strong> An interaction between group and moment factors was observed for Fp1 (<i>p</i> < 0.001); Fp2 (<i>p</i> = 0.001); F7 (<i>p</i> < 0.001); F8 (<i>p</i> < 0.001); F3 (<i>p</i> < 0.001); Fz (<i>p</i> < 0.001); and F4 (<i>p</i> < 0.001). Electrophysiological findings clarified exercisers' specificity and neural efficiency in each prefrontal and frontal subarea.</p><p><strong>Conclusion: </strong> Our findings lend support to the current understanding of the cognitive processes underlying physical exercise and provide new evidence on the relationship between exercise and cortical activity.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 10","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}