Arquivos de neuro-psiquiatria最新文献

Self-compassion in migraine: associations with depression, anxiety, and clinical characteristics. 偏头痛的自我同情：与抑郁、焦虑和临床特征的关系。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-05-01 Epub Date: 2026-04-28 DOI: 10.1055/s-0046-1820105

Ruken Simsekoglu, Zarife Tugce Yıldız, Nilay Garipbas

{"title":"Self-compassion in migraine: associations with depression, anxiety, and clinical characteristics.","authors":"Ruken Simsekoglu, Zarife Tugce Yıldız, Nilay Garipbas","doi":"10.1055/s-0046-1820105","DOIUrl":"10.1055/s-0046-1820105","url":null,"abstract":"Background: Self-compassion (SC), defined as a positive and accepting attitude towards oneself during times of suffering or failure, is receiving more attention in the context of chronic pain disorders. However, very little is known regarding the link between SC, psychological symptoms, and migraine features.Objective: To compare the SC levels of migraine patients to those of healthy controls and investigate the relationships among SC, anxiety, depression, and migraine features.Methods: This cross-sectional study comprised 90 healthy controls (age: 35 ± 9.8 years, 75 female patients) and 98 migraine sufferers (age: 36.7 ± 11.3 years, 84 female patients). The Beck depression inventory, Beck anxiety inventory, and self-compassion scale were completed by the participants.Results: The SC levels were considerably lower in migraine patients. Patients with chronic migraine performed worse than those with episodic migraines on the self-kindness, common humanity, and mindfulness subscales. Patients with medication overuse also had reduced SC. Higher isolation scores were linked to aura presence.Conclusion: We found impaired SC in individuals with migraine, and a connection with greater emotional distress and migraine characteristics. These results demonstrate the possible value of emphasizing SC in migraine therapies, especially for those who suffer from chronic migraine, aura, or medication overuse.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 5","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated dysphagia masking myasthenia gravis diagnosis. 孤立性吞咽困难掩盖重症肌无力的诊断。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-05-01 Epub Date: 2026-03-11 DOI: 10.1055/s-0046-1817045

Isabella Lopes Lusvarghi, Eduarda Heringer Bernis, Rafaela Gatti Lopes, Rafaela Costa Vieira, Breno Franco Silveira Fernandes, Davi Teixeira Urzêdo Queiroz

{"title":"Isolated dysphagia masking myasthenia gravis diagnosis.","authors":"Isabella Lopes Lusvarghi, Eduarda Heringer Bernis, Rafaela Gatti Lopes, Rafaela Costa Vieira, Breno Franco Silveira Fernandes, Davi Teixeira Urzêdo Queiroz","doi":"10.1055/s-0046-1817045","DOIUrl":"10.1055/s-0046-1817045","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by fluctuating skeletal muscle weakness. We report a 61-year-old woman presenting with progressive dysphagia as the sole initial symptom for 15 months, leading to diagnostic delay. Esophageal manometry suggested ineffective motility, and electroneuromyography was normal, reinforcing a non-neurological hypothesis. During hospitalization for worsening dysphagia, cervical magnetic resonance imaging (MRI) incidentally revealed an anterior mediastinal nodule consistent with thymoma. Pulse corticosteroid therapy caused abrupt clinical deterioration, prompting neurological evaluation. Pyridostigmine produced marked improvement within 48 hours, and acetylcholine receptor antibody testing confirmed MG (18.7 nmol/L, radioimmunoassay). Robotic thymectomy revealed a type AB thymoma. The patient remains stable on azathioprine 2.5 mg/kg/day, with oncologic follow-up. This case highlights that MG should be considered in persistent unexplained dysphagia, particularly when symptoms worsen after corticosteroid exposure. Early recognition avoids morbidity and unnecessary invasive procedures.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 5","pages":"1-4"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of transient ischemic attack in a low- and middle-income country: a critical analysis. 低收入和中等收入国家短暂性脑缺血发作的管理：一项批判性分析。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-04-01 Epub Date: 2026-04-07 DOI: 10.1055/s-0046-1818606

Marcos Vinicius Sousa Varão, Guilherme Nobre Nogueira

引用次数: 0

Choreiform Wilson's disease and a distinctive 7-Tesla magnetic resonance imaging finding. 舞蹈样威尔逊氏病和独特的7-特斯拉磁共振成像发现。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-04-01 Epub Date: 2026-03-23 DOI: 10.1055/s-0046-1817044

Ana Rosa Santana, Igor Vilela Brum, Izaely Ramos Prates, Júlio Melão Cordeiro, Rubens Gisbert Cury, Leandro Tavares Lucato, Egberto Reis Barbosa, Jacy Bezerra Parmera

引用次数: 0

High purpose in life of older adults is associated with younger age, higher education, and being female. 老年人生活的高目标与年轻、高等教育和女性有关。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-04-01 Epub Date: 2026-04-07 DOI: 10.1055/s-0046-1818610

Sabrina Aparecida da Silva, Gabriela Dos Santos, Tiago Nascimento Ordonez, Wellington Lourenço Oliveira, Diana Dos Santos Bacelar, Maria Antonia Antunes de Souza, Laydiane Alves Costa, Henrique Salmazo da Silva, Beatriz Aparecida Ozello Gutierrez, Rosa Yuka Sato Chubaci, Sonia Maria Dozzi Brucki, Thais Bento Lima da Silva

{"title":"High purpose in life of older adults is associated with younger age, higher education, and being female.","authors":"Sabrina Aparecida da Silva, Gabriela Dos Santos, Tiago Nascimento Ordonez, Wellington Lourenço Oliveira, Diana Dos Santos Bacelar, Maria Antonia Antunes de Souza, Laydiane Alves Costa, Henrique Salmazo da Silva, Beatriz Aparecida Ozello Gutierrez, Rosa Yuka Sato Chubaci, Sonia Maria Dozzi Brucki, Thais Bento Lima da Silva","doi":"10.1055/s-0046-1818610","DOIUrl":"10.1055/s-0046-1818610","url":null,"abstract":"Purpose in life (PiL) is an important aspect of psychological wellbeing, which can be influenced by sociodemographic factors.To analyze the relationship between sociodemographic variables and PiL in older individuals.A quantitative study that evaluated 189 participants using the PiL Scale (PLS) was conducted. Participants were divided into two groups according to median PLS score. The Mann-Whitney U-test was used to assess group differences, given the non-normal distribution of variables. Spearman's bivariate correlations and a stepwise logistic regression model were applied to identify predictors of PiL.Of the total participants, 77.25% were female. The mean age was significantly lower in the high PiL group (p = 0.017). Spearman's correlations revealed a weak negative relationship between age and PiL (rho = -0.151; p = .038) and a weak positive relationship between schooling and PiL (rho = 0.156; p = 0.032). Logistic regression indicated that higher education (OR = 1.087; p = 0.017) and being female (OR = 2.546; p = 0.018) were associated with higher PiL.High PiL was associated with higher education and being female. Although age showed a negative correlation, the variable did not remain an independent predictor in the final multivariate model.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 4","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mercury exposure and Minamata disease in Brazil: evidence or alarm? 巴西汞暴露与水俣病：证据还是警报？

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-04-01 Epub Date: 2026-04-28 DOI: 10.1055/s-0046-1817051

Marcos Vinicius Sousa Varão, Guilherme Nobre Nogueira, Gunter Gerson

引用次数: 0

Comment on "Is the experience of chronic pain different in frail older adults? A cross-sectional exploratory study". 对“体弱多病的老年人的慢性疼痛体验不同吗？”横断面探索性研究”。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-04-01 Epub Date: 2026-04-07 DOI: 10.1055/s-0046-1818605

Shyam Sundar Sah, Abhishek Kumbhalwar

引用次数: 0

Reply to 'Mercury exposure and Minamata disease in Brazil: evidence or alarm?' 回复“巴西汞暴露与水俣病：证据还是警报？”

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-04-01 Epub Date: 2026-04-28 DOI: 10.1055/s-0046-1820106

Gustavo Maximiano-Alves, Eder Leandro da Silva Dantas, Maria Elena Crespo-Lopez, José Luiz Martins do Nascimento

引用次数: 0

Anti-CGRP monoclonal antibodies for chronic migraine with medication-overuse headache: a conservative meta-analysis. 抗cgrp单克隆抗体治疗慢性偏头痛伴药物滥用性头痛：一项保守荟萃分析。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-03-01 Epub Date: 2026-02-27 DOI: 10.1055/s-0046-1817018

Luana Miyahira Makita, Gabriela das Graças Dos Santos Carolino, Yuri Gubitose de Souza, Heloísa Carneiro Brito, Mariana Oliveira, Giovana Schlichta Adriano Kojima, Milena Ramos Tomé, Júlia Dos Santos Monteiro, Yasmin Bastos Faller, Elcio Juliato Piovesan, Mario Fernando Prieto Peres

{"title":"Anti-CGRP monoclonal antibodies for chronic migraine with medication-overuse headache: a conservative meta-analysis.","authors":"Luana Miyahira Makita, Gabriela das Graças Dos Santos Carolino, Yuri Gubitose de Souza, Heloísa Carneiro Brito, Mariana Oliveira, Giovana Schlichta Adriano Kojima, Milena Ramos Tomé, Júlia Dos Santos Monteiro, Yasmin Bastos Faller, Elcio Juliato Piovesan, Mario Fernando Prieto Peres","doi":"10.1055/s-0046-1817018","DOIUrl":"10.1055/s-0046-1817018","url":null,"abstract":"Chronic migraine (CM) is often complicated by medication-overuse headache (MOH), worsening disability. Although withdrawal of overused medications is recommended, adherence is poor and relapse is frequent. Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway may offer an effective preventive option without requiring discontinuation, but current evidence is limited by few and heterogeneous randomized controlled trials (RCTs).To systematically assess the efficacy and safety of anti-CGRP mAbs in treating CM with MOH (CM + MOH) under a conservative approach.The PubMed, Embase, and Cochrane Central databases were searched for RCTs comparing anti-CGRP mAbs with placebo in adults with CM + MOH. The primary outcome was the mean change in monthly migraine days (MMDs) at 3 months. The secondary outcomes included acute medication use, disability, drug overuse resolution, response rate, and adverse events (AEs). Random-effects models with Sidik-Jonkman estimator and Knapp-Hartung adjustments pooled effect sizes.We included seven RCTs, totalling 3,094 patients. Anti-CGRP mAbs significantly reduced MMDs (mean difference [MD] = -0.35; 95%CI: -0.43 to -0.26) and acute medication use (MD = -0.35; 95%CI: -0.51 to -0.19) compared with placebo. Higher rates, of ≥ 50%, of response (risk ratio [RR] = 1.94; 95%CI: 1.60-2.34) and drug overuse resolution (RR = 1.38; 95%CI: 1.04-1.83) were observed, with no significant increase in AEs (RR = 1.09; 95%CI: 0.85-1.40).Anti-CGRP mAbs were effective and well tolerated in CM + MOH, representing a viable alternative, especially for patients unable to discontinue acute medications. Further research should assess long-term outcomes and subgroup effects.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 3","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Sociodemographic Profile of Familial Amyotrophic Lateral Sclerosis Type 8 Compared to the Sporadic Form. 家族性肌萎缩侧索硬化症8型与散发型的临床和社会人口学特征比较

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2026-03-01 Epub Date: 2026-03-23 DOI: 10.1055/s-0046-1817037

Danilo Jorge da Silva, Sophia Calabria da Silveira, Leonardo Cruz de Souza, Marcelo Maroco Cruzeiro, Thiago Cardoso Vale

{"title":"Clinical and Sociodemographic Profile of Familial Amyotrophic Lateral Sclerosis Type 8 Compared to the Sporadic Form.","authors":"Danilo Jorge da Silva, Sophia Calabria da Silveira, Leonardo Cruz de Souza, Marcelo Maroco Cruzeiro, Thiago Cardoso Vale","doi":"10.1055/s-0046-1817037","DOIUrl":"10.1055/s-0046-1817037","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a rare degenerative disease of motor neurons, predominantly sporadic, with approximately 10% of the cases showing familial inheritance.To characterize the clinical and sociodemographic profile of patients with familial ALS type 8 (fALS8) and compare it with sporadic ALS (sALS).We reviewed the medical records (1997-2022) from a specialized Brazilian center. Patients with a confirmed diagnosis of ALSs were included, and sociodemographic and clinical data were collected.The sample was composed of 89 ALS patients, with a slight female predominance (53%) and a high frequency of fALS8 cases (45%). The fALS8 patients were diagnosed at a younger age, at approximately 50 years, compared to 53 years among the sALS patients (p = 0.043). Lower limb onset predominated in the fALS8 group (87%), while the sALS group showed more heterogeneous presentations, including bulbar onset (14%). The time until the diagnosis was significantly longer in the fALS8 group compared to the sALS group, both from symptom onset (approximately 51 versus 30 months respectively; p < 0.001) and after admission to a specialized center (7 versus 4 months respectively; p = 0.002). Dysphagia and gastrostomy were more frequent in the sALS group compared to the fALS8 group (p = 0.02 and p < 0.01 respectively), and older age at diagnosis was associated with worse functional scores.The fALS8 group presented with distinct clinical and demographic features compared to the sALS group, including younger age at diagnosis, more homogeneous symptom onset, and lower frequency of dysphagia and need for gastrostomy. The diagnosis was more delayed in the fALS8 group, and older age at diagnosis was associated with worse functional status. The current study contributes to the scarce data on fALS8 in South America.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 3","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0