Arquivos de neuro-psiquiatria最新文献

Charcot revived. 夏科恢复。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-06-01 Epub Date: 2025-06-11 DOI: 10.1055/s-0045-1804489

Hélio A G Teive

引用次数: 0

A moral history of seizures: reported causes of seizures in the nineteenth century. 癫痫发作的道德史：19世纪癫痫发作的报告原因。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-06-01 DOI: 10.1055/s-0045-1806829

Márcio Pinheiro Lima, Elza Márcia Targas Yacubian

引用次数: 0

Amyloid immunotherapy for Alzheimer's disease: the case for cautious adoption. 淀粉样蛋白免疫疗法治疗阿尔茨海默病：谨慎采用的案例。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-05-09 DOI: 10.1055/s-0045-1807718

Jonathan M Schott, Charles R Marshall

引用次数: 0

Could minor neurological dysfunction be a type of non-cerebral palsy motor impairment? 轻微的神经功能障碍可能是一种非脑性麻痹运动障碍吗？

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-06-01 DOI: 10.1055/s-0045-1809359

Ana Paula Hamad, Carla Andrea Tanuri Cardoso Caldas, Isabella Cristina Mendes de Sá E Silva, Marina Estima Neiva Nunes

{"title":"Could minor neurological dysfunction be a type of non-cerebral palsy motor impairment?","authors":"Ana Paula Hamad, Carla Andrea Tanuri Cardoso Caldas, Isabella Cristina Mendes de Sá E Silva, Marina Estima Neiva Nunes","doi":"10.1055/s-0045-1809359","DOIUrl":"https://doi.org/10.1055/s-0045-1809359","url":null,"abstract":"Non-cerebral palsy motor impairments have been increasing over time, especially in preterm-born children, with a variety of labels, including, but not limited to, developmental coordination disorder and minor neurological dysfunction. They may not only negatively affect the child in their daily life activities, but are also associated with cognitive, emotional, and behavioral disorders, as well as decreased academic performance. Since there is a paucity of literature on non-cerebral palsy motor impairment, the main objective of the present study is to assess minor neurological dysfunction in the context of neurodevelopment. We reviewed the medical literature using the following search terms: preterm infants; follow-up; non-cerebral palsy motor impairment or disability; minor neurological dysfunction; developmental coordination disorder; neurological soft signs; and Touwen Neurological Examination. We compiled evidence-based data on minor neurological dysfunction critical domains, diagnosis, etiological factors and the influence of age and puberty in minor neurological signs. We also listed the cohort studies that used the Touwen Neurological Examination for premature or term-born follow-up, including those that suggest an association between minor neurological dysfunction and developmental coordination disorder as a motor impairment beyond cerebral palsy. Moreover, we found significant evidence of a correlation involving minor neurological dysfunction and cognitive, behavioral, and learning abilities, which, all in all, means that these children particularly deserve special attention regarding social, educational and healthcare resources. Furthermore, since motor activity seems to play an important role in the physical, mental, and neurological health of typical children, different approaches to education could have a positive impact on neurological development.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 5","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibodies against beta-amyloid protein (lecanemab and donanemab) should not be used in the treatment of Alzheimer's disease. 抗β -淀粉样蛋白单克隆抗体（lecanemab和donanemab）不应用于治疗阿尔茨海默病。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-05-09 DOI: 10.1055/s-0045-1808082

Ricardo Nitrini, Adalberto Studart-Neto

引用次数: 0

Paul Hoffmann and the cutaneous silent period test. 保罗·霍夫曼和皮肤静默期试验。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-06-01 DOI: 10.1055/s-0045-1806826

Otto Jesus Hernández Fustes, Cláudia Suemi Kamoi Kay, Paulo José Lorenzoni, Renata Dal-Prá Ducci, Paula Raquel do Vale Pascoal Rodrigues, Rosana Herminia Scola

引用次数: 0

Telemedicine transforming stroke care in Piauí: an analysis of a state-wide initiative's first year. 远程医疗在Piauí改变中风护理：对一个州范围内的倡议第一年的分析。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-06-01 DOI: 10.1055/s-0045-1807719

Irapuá Ferreira Ricarte, Ícaro Araújo de Sousa, Romilto Costa Pacheco Neto, Arthur de Oliveira Veras, Camila Victória da Silva, Cristina Calmon de Araújo Mascarenhas, Matheus Felipe da Silva, Gisele Sampaio Silva, Octávio Marques Pontes-Neto

{"title":"Telemedicine transforming stroke care in Piauí: an analysis of a state-wide initiative's first year.","authors":"Irapuá Ferreira Ricarte, Ícaro Araújo de Sousa, Romilto Costa Pacheco Neto, Arthur de Oliveira Veras, Camila Victória da Silva, Cristina Calmon de Araújo Mascarenhas, Matheus Felipe da Silva, Gisele Sampaio Silva, Octávio Marques Pontes-Neto","doi":"10.1055/s-0045-1807719","DOIUrl":"https://doi.org/10.1055/s-0045-1807719","url":null,"abstract":"Prior to October 2022, stroke patients in Piaui lacked access to both stroke unit care and thrombolytic treatment, until the implementation of a telemedicine-based stroke care program.To conduct a descriptive analysis of patients suspected of stroke who received telemedicine-based care in Piauí during the first year of the program's implementation.We conducted a retrospective analysis of 868 patients treated from October 2022 to September 2023 under the state-wide stroke care program, which includes 6 Stroke Treatment Centers distributed around the state. Utilizing data from the JOIN telemedicine platform, the analysis focused on patient demographics, stroke types, treatment timelines, and outcomes of thrombolytic treatment.The cohort included 868 patients, with a mean age of 67.2 years, out of whom 55.5% were male. Chronic hypertension was reported in 57.8% and diabetes in 22.5% of the patients. The average onset-to-door time was 3.3 hours, door-to-computed tomography time was 23 minutes, and door-to-needle time averaged 67 minutes. Thrombolysis was administered to 15.6% of all stroke cases, with 31.8% among those being ischemic strokes. Among patients who arrived within the thrombolytic time window, the rate was 27.3%.The introduction of a telemedicine-based stroke care program in Piauí has significantly enhanced access to essential stroke treatments, demonstrating its effectiveness in overcoming healthcare disparities. The initiative's success underscores the potential of telemedicine as a scalable model for improving stroke care in regions with limited healthcare resources. Future efforts will focus on reducing treatment times and expanding stroke care infrastructure to ensure comprehensive patient care.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 5","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiamyloid therapies for Alzheimer's disease: an experts' dialogue on facts and controversies. 阿尔茨海默病的抗淀粉样蛋白疗法：关于事实和争议的专家对话。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-05-09 DOI: 10.1055/s-0045-1808083

Paulo Caramelli

引用次数: 0

Endovascular thrombectomy for large-core stroke: a meta-analysis with trial sequential analysis. 大核卒中的血管内血栓切除术：一项荟萃分析与试验序列分析。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1055/s-0045-1806827

Marco Antonnio Rocha Dos Santos, Pierludovico Moro, Abner Lucas Balduino de Souza, Lauren Nirta, Thaís Pereira Mendes, Laura de Lima Xavier, Ming-Chieh Ding

{"title":"Endovascular thrombectomy for large-core stroke: a meta-analysis with trial sequential analysis.","authors":"Marco Antonnio Rocha Dos Santos, Pierludovico Moro, Abner Lucas Balduino de Souza, Lauren Nirta, Thaís Pereira Mendes, Laura de Lima Xavier, Ming-Chieh Ding","doi":"10.1055/s-0045-1806827","DOIUrl":"10.1055/s-0045-1806827","url":null,"abstract":"Recent studies have reported that endovascular thrombectomy (ET) may improve neurological outcomes in large-core stroke.We performed a systematic review and meta-analysis to compare the pooled efficacy and safety of ET and of the best medical treatment among patients with large-core stroke.We searched the PubMed/MEDLINE, Scopus, and Cochrane databases from inception to November 2023. The inclusion criteria were randomized controlled trials (RCTs) comparing ET and the best medical treatment available among patients with large-core stroke (Alberta Stroke Program Early Computed Tomography Score [ASPECTS] < 6 or ischemic core > 50 mL on perfusion imaging) within 24 hours of symptom onset.We included 6 RTCs comprising 1,887 patients (ET group: n = 945). Endovascular thrombectomy was associated with good neurological outcomes (odds ratio [OR]: 2.92; 95% confidence interval [95%CI]: 2.17-3.93), or independent walking (OR: 2.22; 95%CI: 1.72-2.86). Trial sequential analysis confirmed a robust statistical significance for good neurological outcomes favoring ET. Endovascular thrombectomy was associated with higher risks of developing intracranial bleeding (OR: 2.65; 95%CI: 1.35-5.22) and symptomatic intracranial bleeding (OR: 1.83; 95%CI: 1.14-2.94). There were no differences between the groups regarding mortality or decompressive craniectomy. Patients submitted to non-contrast computed tomography (CT) with CT angiography (CTA) scans were analyzed separately and showed good neurological outcomes, comparable to those of the patients submitted to other imaging modalities (OR: 3.24; 95%CI: 1.52-6.92).Endovascular thrombectomy was associated with good neurological outcomes and independent walking in patients with large-core acute ischemic stroke. However, it was also associated with an increased risk of developing intracranial bleeding. Non-contrast head CT with CTA scans may be appropriate for screening patients to undergo ET.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 5","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How the use of FDG PET is improving the diagnosis of dementia in a reference center in Recife, Brazil. 在巴西累西腓的一个参考中心，FDG PET的使用如何改善痴呆的诊断。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-05-21 DOI: 10.1055/s-0045-1808086

Luisa Couceiro de Albuquerque Macêdo, Raphaelly Ribeiro Campos, Luiz Eduardo Duarte Borges Nunes, Mariana Gonçalves Maciel Pinheiro, Alberto Henrique Torres Trindade da Silva, Maria Regina Vendas Carneiro Leão, Aldson Dos Santos Silva, Felipe Alves Mourato, Simone Cristina Soares Brandão, Breno José Alencar Pires Barbosa

{"title":"How the use of FDG PET is improving the diagnosis of dementia in a reference center in Recife, Brazil.","authors":"Luisa Couceiro de Albuquerque Macêdo, Raphaelly Ribeiro Campos, Luiz Eduardo Duarte Borges Nunes, Mariana Gonçalves Maciel Pinheiro, Alberto Henrique Torres Trindade da Silva, Maria Regina Vendas Carneiro Leão, Aldson Dos Santos Silva, Felipe Alves Mourato, Simone Cristina Soares Brandão, Breno José Alencar Pires Barbosa","doi":"10.1055/s-0045-1808086","DOIUrl":"https://doi.org/10.1055/s-0045-1808086","url":null,"abstract":"Since the advent of 18F-2-fluoro-2-deoxy-D-glucose ([18F]FDG, henceforth, FDG) in the 1970s as a neurochemical tracer, FDG positron emission tomography (PET) has been used for research in dementia and to help diagnose dementing neurodegenerative disorders. However, FDG PET is still unavailable in most centers, especially those in low- and middle-income countries, and there is limited data on biomarkers from patients in diverse populations, such Latin Americans.To analyze the main indications and how the use of FDG PET helped improve the diagnosis of dementia in a specialized center in Recife, one of the largest cities in Northeastern Brazil.We retrospectively analyzed data from 62 individuals under follow-up at our center between 2018 and 2023 who had a clinical diagnosis of dementia or mild cognitive impairment and underwent FDG PET scans.In 21/29 (72.4%) patients, FDG PET helped investigate the types of atypical neurodegenerative dementias; in 14/24 (58.3%), it clarified the clinical question in the investigation of early-onset dementia syndromes; and, in 9 cases, it was performed to differentiate between degenerative and non-degenerative dementias.These numbers may set the foundation for further longitudinal analyses and collaborative studies including participants from Northeastern Brazil.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 5","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0