Arquivos de neuro-psiquiatria最新文献_第4页

The relevance of magnetic resonance imaging in the era of Alzheimer's disease biomarkers.

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1055/s-0045-1801863

Marcio Luiz Figueredo Balthazar

引用次数: 0

Reply to the letter to "Cultural adaptation and reliability assessment of the Hammersmith neonatal neurological examination for Brazilian newborns at risk of cerebral palsy".

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1055/s-0045-1802323

Mayara Thais Correr, Luzia Iara Pfeifer

引用次数: 0

Factors influencing quality of life in patients with temporal lobe epilepsy.

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI: 10.1055/s-0045-1802552

Amina Tani, Nawal Adali

{"title":"Factors influencing quality of life in patients with temporal lobe epilepsy.","authors":"Amina Tani, Nawal Adali","doi":"10.1055/s-0045-1802552","DOIUrl":"https://doi.org/10.1055/s-0045-1802552","url":null,"abstract":"Background: Temporal lobe epilepsy (TLE) predisposes individuals to cognitive difficulties and psychosocial consequences. Evaluating its impact on quality of life (QOL) is essential for patient care.Objective: To identify factors influencing QOL in low-income patients with TLE.Methods: An institution-based cross-sectional study was conducted on 40 patients with TLE during neurological consultations at a day clinic in Agadir, Morocco. The Quality of Life in Epilepsy Inventory-31 (QOLIE-31) was used to measure QOL. Multivariate linear regression analysis was performed to assess the associations between QOL and demographic, clinical, psychiatric, social, and cognitive variables. Results were considered statistically significant at a p-value < 0.05.Results: The mean overall QOL score was 48.14 ± 22.02. Among the seven scales of the QOLIE-31, the Seizure Worry scale had the lowest mean score. Cognitive function, social support, and self-esteem were positively associated with QOL. In contrast, memory complaints, seizure duration, seizure frequency, anxiety, and depression were negatively associated with QOL.Conclusion: While current interventions primarily target seizure control, our findings emphasize the need for holistic approaches that address both cognitive and psychosocial challenges to optimize QOL.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 1","pages":"1-10"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of lipid metabolism in cognitive impairment. 脂质代谢在认知障碍中的作用。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.1055/s-0044-1792097

Meifang Xu, Liyuan Wang, Yun Meng, Guiqiong Kang, Qing Jiang, Tao Yan, Fengyuan Che

{"title":"The role of lipid metabolism in cognitive impairment.","authors":"Meifang Xu, Liyuan Wang, Yun Meng, Guiqiong Kang, Qing Jiang, Tao Yan, Fengyuan Che","doi":"10.1055/s-0044-1792097","DOIUrl":"10.1055/s-0044-1792097","url":null,"abstract":"Alzheimer's disease (AD), diabetic cognitive impairment (DCI), and vascular dementia (VD) are considered the most common causes of severe cognitive impairment in clinical practice. Numerous factors can influence their progression, and many studies have recently revealed that metabolic disorders play crucial roles in the progression of cognitive impairment. Mounting evidence indicate that the regulation of lipid metabolism is a major factor in maintaining brain homeostasis. Generally, abnormalities in lipid metabolism can affect amyloid-beta (Aβ) deposition, tau hyperphosphorylation, and insulin resistance through lipid metabolic signaling cascades; affect the neuronal membrane structure, neurotransmitter synthesis and release; and promote synapse growth, which can impact neural signal transmission and exacerbate disease progression in individuals with cognitive impairment, including AD, DCI, and VD. Moreover, apolipoprotein E (APOE), a key protein in lipid transport, is involved in the occurrence and development of the aforementioned diseases by regulating lipid metabolism. The present article mainly discusses how lipid metabolic disorders in the brain microenvironment are involved in regulating the progression of cognitive impairment, and it explores the regulatory effects of targeting the key lipid transport protein APOE in the context of the role of lipid metabolism in the common pathogenesis of three diseases-Aβ deposition, tau hyperphosphorylation, and insulin resistance-which will help elucidate the potential of targeting lipid metabolism for the treatment of cognitive impairment.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 1","pages":"1-13"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory pathway abnormalities in Parkinson's disease.

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1055/s-0045-1801844

Rafaela Valiengo de Souza, Liliane Aparecida Fagundes Silva, Carla Gentile Matas

{"title":"Auditory pathway abnormalities in Parkinson's disease.","authors":"Rafaela Valiengo de Souza, Liliane Aparecida Fagundes Silva, Carla Gentile Matas","doi":"10.1055/s-0045-1801844","DOIUrl":"https://doi.org/10.1055/s-0045-1801844","url":null,"abstract":"Background: Parkinson's disease (PD) is a degenerative, progressive, chronic disease that mainly affects the central nervous system, caused by dopamine deficiency. One of the ways to evaluate the central nervous system is with auditory evoked potentials (AEP).Objective: To characterize the audiometric responses, and the auditory brainstem response (ABR), and cortical auditory evoked potentials (CAEP) in individuals with PD.Methods: Thirty-two patients aged between 40 and 81 of both sexes were assessed, 16 with PD (study group [SG]) and 16 without PD (control group [CG]) matched for sex and age. The subjects were assessed using pure tone audiometry, ABR with click stimuli, and CAEP using the oddball paradigm with tone burst and speech stimuli. The results were compared between the groups using a repeated measures analysis of variance (ANOVA) test.Results: In pure-tone audiometry, significantly higher hearing thresholds were found in the SG at 6 and 8 kHz. For the ABR, no differences were observed between groups. The CAEP analysis did not find statistical differences in the latencies between the groups, however, the SG presented smaller amplitudes of P1-N1, P2-N2, and N2-P3 than the CG.Conclusion: The results of this study showed a significantly higher threshold in higher frequencies in PD. Although no differences were observed at the brainstem level, the decrease in amplitude of all components in patients with PD in the CAEP suggests a deficit in both automatic and attentional cortical processing of acoustic stimuli.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 1","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurology pioneers in Japan. 日本神经病学的先驱。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.1055/s-0044-1791661

Hélio A Ghizoni Teive, Léo Coutinho, Francisco E C Cardoso, Shoji Tsuji

引用次数: 0

Letter to "Cultural adaptation and reliability assessment of the Hammersmith neonatal neurological examination for Brazilian newborns at risk of cerebral palsy".

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1055/s-0045-1802309

Tathiana Ghisi de Souza

引用次数: 0

Charcot's Russian pupils. 沙尔科的俄罗斯学生

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI: 10.1055/s-0044-1789226

Hélio Afonso Ghizoni Teive, Léo Coutinho, Carlos Henrique Ferreira Camargo

引用次数: 0

Dengue and severe dengue with neurological complications: a challenge for prevention and control. 登革热和伴有神经系统并发症的严重登革热：预防和控制的挑战。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2024-12-01 Epub Date: 2024-12-03 DOI: 10.1055/s-0044-1792091

Emanuelle de Oliveira Francelino, Marzia Puccioni-Sohler

{"title":"Dengue and severe dengue with neurological complications: a challenge for prevention and control.","authors":"Emanuelle de Oliveira Francelino, Marzia Puccioni-Sohler","doi":"10.1055/s-0044-1792091","DOIUrl":"10.1055/s-0044-1792091","url":null,"abstract":"Dengue is the main urban arbovirus in the Americas. The disease manifests in a varied spectrum: from asymptomatic cases to those with neurological involvement, which is considered a severe form of the disease. Its annual reemergence represents a serious public health problem. The rise in the number of cases causes an increase in the number of patients with neurological manifestations of the disease, which can range from headaches to more serious conditions such as encephalitis and Guillain-Barré syndrome, with high potential of death or sequelae. Dengue prevention and control strategies should also be a concern for neurologists. The aim of the present study is to carry out a narrative review of the current methods to prevent dengue fever and its severe forms, such as cases with neurological complications. The main control measures include vaccination, which is still carried out on a small scale, vector control, and individual protection. The CYD-TDV/Dengvaxia and TAK-003/DENVax vaccines, licensed for use by the Brazilian National Health Regulatory Agency (Agência Nacional de Vigilância Sanitária, ANVISA, in Portuguese), show efficacy against hospitalizations of 72.7% (95% confidence interval [95%CI]: 62.3-80.3%) and of 90.4% (95%CI: 82.6-94.7%) respectively. The TV003/TV005 vaccine, which is being studied by Intituto Butantan in Brazil, shows promising results, with an efficacy of 79.6% for symptomatic dengue. Vector control is based on biotechnological and behavioral measures, as well as on the improvement of basic sanitation conditions. The main individual protection measure is the use of topical repellents (icaridin). All of these actions represent important tools for the prevention of dengue fever and its neurological complications.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Median nerve impairment in leprosy: how does it differ from the classic carpal tunnel syndrome? 麻风病的正中神经损伤：与经典腕管综合征有何不同？

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1055/s-0044-1792092

Pedro Henrique Sirotheau Corrêa Alves, Fernanda de Oliveira Cirino, Leonardo Peixoto Garcia, João Paulo Moreira Fernandes, Andrea De Martino Luppi, Douglas Eulálio Antunes, Raquel Campos Pereira, Wilson Marques Junior, Isabela Maria Bernardes Goulart, Diogo Fernandes Dos Santos

{"title":"Median nerve impairment in leprosy: how does it differ from the classic carpal tunnel syndrome?","authors":"Pedro Henrique Sirotheau Corrêa Alves, Fernanda de Oliveira Cirino, Leonardo Peixoto Garcia, João Paulo Moreira Fernandes, Andrea De Martino Luppi, Douglas Eulálio Antunes, Raquel Campos Pereira, Wilson Marques Junior, Isabela Maria Bernardes Goulart, Diogo Fernandes Dos Santos","doi":"10.1055/s-0044-1792092","DOIUrl":"10.1055/s-0044-1792092","url":null,"abstract":"Background: Carpal tunnel syndrome (CTS) has already been described as a possible form of neural leprosy presentation. However, the median nerve can be involved in this neuropathy in proximal segments and, sometimes, with an asymmetric impairment of the digital branches.Objective: To detail the pattern of median nerve impairment through nerve conduction study (NCS) and ultrasound evaluation.Methods: This cross-sectional study comprises 15 primary neural leprosy (PNL) patients and 14 patients with CTS who underwent peripheral nerve ultrasonography and NCS evaluation.Results: From the total, 92.8% of patients with CTS and 80% with PNL had bilateral impairment of the median nerve, with 27 nerves in each group. Considering the cross-sectional area (CSA) of the tunnel (Mt) segment, 63% of the nerves in the CTS and 74.1% in the PNL groups were found to be thickened, with an average CSA of 13.4 ± 4.4 and 12.4 ± 4.6, respectively (p = 0.18). The CSA of the proximal tunnel (Mpt) segment showed thickening in only 3.7% in the CTS group and 96.3% in the PNL (p < 0.0001), with an average of 6.6 ± 1.3 and 17.0 ± 6.7, respectively (p < 0.001). Finally, 88.9% of the nerves in the PNL group and only 7.4% in the CSA (p < 0.0001) showed a reduction in conduction velocity in the distal forearm, with an average of 41.0 ± 6.3 and 53.2 ± 5.2, respectively (p < 0.0001).Conclusion: The presence of neural thickening and demyelinating impairment in the segments proximal to the carpal tunnel favors the diagnosis of leprosy.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 12","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0