Arquivos de neuro-psiquiatria最新文献_第4页

Galvanic vestibular stimulation to rehabilitate postural instability in Parkinson's disease. 前庭电刺激对帕金森病患者体位不稳定的修复作用。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806812

Anna Paula Batista de Ávila Pires, Ludimila Labanca, Paulo Pereira Christo, Maurício Campelo Tavares, Jordana Carvalhais Barroso, Maria Luiza Diniz, Denise Utsch Gonçalves

{"title":"Galvanic vestibular stimulation to rehabilitate postural instability in Parkinson's disease.","authors":"Anna Paula Batista de Ávila Pires, Ludimila Labanca, Paulo Pereira Christo, Maurício Campelo Tavares, Jordana Carvalhais Barroso, Maria Luiza Diniz, Denise Utsch Gonçalves","doi":"10.1055/s-0045-1806812","DOIUrl":"https://doi.org/10.1055/s-0045-1806812","url":null,"abstract":"Background: Galvanic vestibular stimulation (GVS) is a non-invasive technique employed to rehabilitate balance by delivering low-intensity, short-duration electrical stimulation to the mastoid bones, effectively activating the vestibulospinal tract.Objective: To evaluate the effects of GVS on balance in patients with Parkinson's disease (PD) and postural instability.Methods: In this clinical study, 25 PD patients with postural instability in the ON phase (best effect of dopaminergic medication) underwent GVS. Balance was assessed using the Berg Balance Scale (BBS), the Timed Up and Go (TUG) test, and posturography on a force platform. Electrical current intensity was progressively increased between the mastoids, starting at 1.0 mA and reaching 3.5 mA by the 6th session, with this level maintained until the 8th session. Stimulation duration began at 9 minutes in the 1st session, increased to 30 minutes by the 3rd session, and was sustained through the 8th session.Results: A blinded comparison of pre- and post-GVS evaluations demonstrated significant improvements in BBS (p = 0.00001) and TUG (p = 0.00003) scores. Posturography showed an increase in the stability limit area (p = 0.026) and the general balance index (p = 0.001).Conclusion: In the therapeutic management of postural instability in PD, GVS emerges as a promising complementary strategy for enhancing balance. Further research is needed to determine whether these improvements persist after GVS cessation.Registration of clinical trial: https://ensaiosclinicos.gov.br/rg/RBR-22j8728.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 3","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1055/s-0045-1806749

引用次数: 0

Characteristics of traumatic brain injury in children and adolescents hospitalized in a Brazilian trauma reference center: a retrospective cross-sectional study. 巴西创伤参考中心住院儿童和青少年创伤性脑损伤的特点：一项回顾性横断面研究。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806743

José Roberto Tude Melo, Caio Vinicius de Almeida Chaves, Cindy Kawano, Maria Antonia Coladeti Fernandes, Reem Hussin, Jean Gonçalves de Oliveira, José Carlos Esteves Veiga

{"title":"Characteristics of traumatic brain injury in children and adolescents hospitalized in a Brazilian trauma reference center: a retrospective cross-sectional study.","authors":"José Roberto Tude Melo, Caio Vinicius de Almeida Chaves, Cindy Kawano, Maria Antonia Coladeti Fernandes, Reem Hussin, Jean Gonçalves de Oliveira, José Carlos Esteves Veiga","doi":"10.1055/s-0045-1806743","DOIUrl":"https://doi.org/10.1055/s-0045-1806743","url":null,"abstract":"Background: Approximately 20% of victims of traumatic brain injury (TBI) in Brazil are children and adolescents, with more than 900 deaths per year.Objective: To describe the characteristics and epidemiological profile of children and adolescents with TBI in the city of São Paulo, Brazil, according to age groups and metropolitan area of occurrence of the events leading to trauma.Methods: We conducted a retrospective cross-sectional study with a review of consecutive medical records of children and adolescents with TBI hospitalized and treated at a level-1 trauma center in São Paulo between 2019 and 2023.Results: In the period proposed for the study, 196 children and adolescents suffered TBIs. They had a median age of 5 (interquartile range [IQR] 10-1.75) years and were predominantly boys (71%), of white skin color/race (55%), and coming from the north zone of the metropolitan region of São Paulo (44%). Domestic accidents were the main causes of TBI (61%), followed by traffic accidents (24%). The mean length of hospital stay was of 13 (standard deviation [SD] ± 26) days, and the in-hospital mortality rate was of 3%.Conclusion: We found a predominance of children and adolescents with TBI coming from the north zone of the metropolitan region of São Paulo, with a prevalence of falls from heights above the ground among children ≤ 9 years of age and trampling among children older than this age. Preventive actions must be established after reflections on socioeconomic issues and considering the metropolitan area where the accidents occur and the age group.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 3","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateral ventricle central neurocytoma with lipidization: a case report of an underrecognized presentation. 侧脑室中枢神经细胞瘤伴脂化：一例未被充分认识的表现。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806925

Daniella Karassawa Zanoni, Osorio Lopes Abath Neto, Nitesh Shekhrajka, Márcio Luís Duarte, Leonardo Furtado Freitas

引用次数: 0

Practical recommendations for diagnosis, management, and follow-up of Niemann-Pick type-C disease patients: a Brazilian perspective. Niemann-Pick - c型疾病患者诊断、管理和随访的实用建议：巴西视角

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-05-09 DOI: 10.1055/s-0045-1807714

Dafne Dain Gandelman Horovitz, André Pessoa, Marcondes Cavalcante França Junior, Roberto Giugliani, Carolina Fischinger Moura de Souza, Emília Katiane Embiruçu, Pedro Braga-Neto, Charles Marques Lourenço

{"title":"Practical recommendations for diagnosis, management, and follow-up of Niemann-Pick type-C disease patients: a Brazilian perspective.","authors":"Dafne Dain Gandelman Horovitz, André Pessoa, Marcondes Cavalcante França Junior, Roberto Giugliani, Carolina Fischinger Moura de Souza, Emília Katiane Embiruçu, Pedro Braga-Neto, Charles Marques Lourenço","doi":"10.1055/s-0045-1807714","DOIUrl":"https://doi.org/10.1055/s-0045-1807714","url":null,"abstract":"Niemann-Pick type-C (NPC) disease is a rare genetic condition with a clinical spectrum ranging from a fatal prenatally-presenting and quickly lethal disorder to an adult-onset chronic neurodegenerative condition. Given the scarcity of information regarding NPC disease in Brazil, a group of experts decided to discuss some disease-related aspects at the national level. The present manuscript describes the results of a Brazilian consensus meeting conducted to propose recommendations for the diagnosis, management, and follow-up of NPC disease in Brazil, considering the clinical practice point of view. These recommendations include patient characteristics on clinical presentation, as systemic and neurological manifestations according to the age group and atypical manifestations; a flowchart for diagnostic confirmation, considering the Brazilian scenario; and treatment, encompassing disease-modifying therapy, supportive care, and patients' follow-up. The expert panel provided an objective basis of recommendations on NPC diagnosis and management in Brazil. The authors expect that this manuscript will help clinicians to identify, adequately treat and follow-up NPC patients in Brazil.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 3","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mobility parameters in individuals with Parkinson's disease with and without freezing of gait. 评估帕金森病患者在步态冻结和不冻结情况下的活动参数。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-27 DOI: 10.1055/s-0045-1806821

Cristiane Ramos de Morais, Tamine T C Capato, Ariana Moura Cabral, Adriano de Oliveira Andrade

{"title":"Evaluation of mobility parameters in individuals with Parkinson's disease with and without freezing of gait.","authors":"Cristiane Ramos de Morais, Tamine T C Capato, Ariana Moura Cabral, Adriano de Oliveira Andrade","doi":"10.1055/s-0045-1806821","DOIUrl":"https://doi.org/10.1055/s-0045-1806821","url":null,"abstract":"Background: Individuals with Parkinson's disease (PD) often experience gait disturbances, and one of the most disabling is freezing of gait (FOG), which is characterized by the inability to initiate or continue walking. To identify its impact on the mobility of PD patients, it is necessary to objectively assess mobility and conduct systematic gait evaluations.Objective: To evaluate mobility and gait parameters in individuals with PD with and without FOG.Methods: The present cross-sectional study included a group of individuals with PD, divided into those with and without FOG, and a healthy control group. The Timed Up and Go (TUG) test was used to evaluate gait and mobility of the participants. Activities of daily living and motor performance in PD patients were assessed through parts II and III of the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS), while FOG was assessed through the New Freezing of Gait Questionnaire (NFOG-Q).Results: A significant difference between the case and control groups was observed in the mean time it took to perform the TUG test, regardless of FOG, during the off-medication state. Unlike the group without FOG, there was a difference in the time it took to perform the tests between medication states in the group with FOG. Additionally, a correlation was found between TUG time and MDS-UPDRS scores in the FOG group.Conclusion: Mobility in PD is influenced by medication effect and the presence of FOG. The results highlight the importance of objective and systematic gait evaluations to identify mobility problems, develop effective rehabilitation strategies, and optimize pharmacological treatments, especially for individuals with FOG.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 3","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocysticercosis and cerebral hemodynamic changes: can transcranial Doppler be the key? 神经囊虫病与脑血流动力学改变：经颅多普勒是关键吗？

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-03-25 DOI: 10.1055/s-0045-1804918

Prateek Kumar Panda, Indar Kumar Sharawat

引用次数: 0

Do patients with cervical dystonia present a greater risk and more fear of falling? 颈肌张力障碍患者是否有更大的跌倒风险和更大的跌倒恐惧？

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-27 DOI: 10.1055/s-0045-1806822

Sibele Yoko Mattozo Takeda, Ana Félix de Souza, Iara Ferreira Penteado, Djanira Aparecida da Luz Veronez, Hélio Afonso Ghizoni Teive

{"title":"Do patients with cervical dystonia present a greater risk and more fear of falling?","authors":"Sibele Yoko Mattozo Takeda, Ana Félix de Souza, Iara Ferreira Penteado, Djanira Aparecida da Luz Veronez, Hélio Afonso Ghizoni Teive","doi":"10.1055/s-0045-1806822","DOIUrl":"https://doi.org/10.1055/s-0045-1806822","url":null,"abstract":"Background: Cervical dystonia (CD) is a movement disorder characterized by involuntary contractions that affect the muscles of the cervical region, causing movements in a twisting pattern. Its chronic-progressive nature can lead to pain, impaired mobility, and greater propensity to falls.Objective: To verify gait and balance characteristics and their correlation with the risk and fear of falling in 46 CD patients.Methods: The present was a descriptive and cross-sectional study. For the assessments, we sued the Berg Balance Scale (BBE), the Tinetti Scale (also known as the Performance-Oriented Mobility Assessment, POMA), the Dynamic Gait Index (DGI), the Fall Efficacy Scale-International (FES-I), and the Functional Reach Test (FRT). The patients were recruited during their routine consultations, before the administration of botulinum toxin. For data analysis, we used the BioEstat 5.0 software (free) to verify the distribution of samples (Shapiro-Wilk test) and the correlations among variables (Spearman test) considering p ≤ 0.05%.Results: The results showed that the patients presented gait changes related to static and dynamic components of balance. Therefore, we observed a greater propensity to falls, with a correlation involving lack of balance, a greater risk of falling and, consequently, more fear of falling.Conclusion: We verified that changes in the balance of CD patients have a negative impact on gait, increase the risk and the fear of falling, and can lead the individual to restrict their activity levels.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 3","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STAC3 gene congenital myopathy and malignant hyperthermia: a crossroads between neurology and anesthesia. STAC3基因先天性肌病和恶性高热：神经病学和麻醉的十字路口。

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-04-22 DOI: 10.1055/s-0045-1806734

Mary Santos Silva, Ricardo Nakamura, Marcia Rosana Arjona, Thue Peres Colferai Del Monaco, Mauricio Luiz Malito, Taís Oliveira Sampaio, Samantha Lopes de Oliveira, Juliana Silva de Almeida Magalhães, Marcela Camara Machado-Costa, Helga Cristina Almeida Silva

{"title":"STAC3 gene congenital myopathy and malignant hyperthermia: a crossroads between neurology and anesthesia.","authors":"Mary Santos Silva, Ricardo Nakamura, Marcia Rosana Arjona, Thue Peres Colferai Del Monaco, Mauricio Luiz Malito, Taís Oliveira Sampaio, Samantha Lopes de Oliveira, Juliana Silva de Almeida Magalhães, Marcela Camara Machado-Costa, Helga Cristina Almeida Silva","doi":"10.1055/s-0045-1806734","DOIUrl":"https://doi.org/10.1055/s-0045-1806734","url":null,"abstract":"STAC3 gene congenital myopathy and malignant hyperthermia (MH) represent an important crossroads between neurology and anesthesia, where the prompt recognition of the clinical characteristics, and the collaboration between neurologists and anesthesiologists, are essential to early diagnosis and prevention of adverse critical events. This gene is associated with a congenital myopathy first reported as Native American myopathy (NAM), a rare condition characterized by dysmorphisms, contractures, muscular complaints, and scoliosis. As a rare pharmacogenetic hypermetabolic disease, MH is triggered by halogenated agents and/or succinylcholine, linked to variants in the RYR1, CACNA1S, or STAC3 genes. Our objective was to analyze the characteristics of a Brazilian case series of STAC3 gene myopathy associated with MH and to review previous reports. We report three MH crises, in two boys and one girl, 2 to 15 years old. All of them received halogenated agents and one additionally received succinylcholine. Two patients presented two to four previous uneventful general anesthesia. The MH crises in this series of patients with STAC3 gene mutations demonstrated variable clinical characteristics (expressivity) and occurrence (penetrance). Neuromuscular patients with findings suggestive of STAC3 myopathy should increase diagnostic suspicion regarding the risk of MH. Conversely, the careful evaluation of the anesthetic antecedents of neuromuscular patients can help to restrict the candidate genes. Additionally, Brazilian neurologists can notify neurological patients with antecedents of adverse events during anesthesia to the Brazilian Registry of Neurological Diseases (Registro Brasileiro de Doenças Neurológicas, REDONE, in Portuguese).","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 3","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How great was the influence of his origins and descendants on Charcot's behaviors? 他的出身和后代对夏可行为的影响有多大？

IF 1 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-03-01 Epub Date: 2025-05-09 DOI: 10.1055/s-0045-1806921

Hélio A Ghizoni Teive, Léo Coutinho, Carlos Henrique Ferreira Camargo, Gustavo L Franklin, Olivier Walusinsi

引用次数: 0