Arquivos de neuro-psiquiatria最新文献

{"title":"Recovery estimates and prognostic factors for oculomotor nerve palsy.","authors":"Daniel Lucio Willing, Alice Giotta Lucifero, Marcos Devanir Silva da Costa, Juan Carlos Ahumada-Vizcaíno, Raphael Wuo-Silva, Feres Chaddad-Neto","doi":"10.1055/s-0046-1827066","DOIUrl":"10.1055/s-0046-1827066","url":null,"abstract":"<p><strong>Background: </strong>Third cranial nerve (III CN) palsy is an extremely disabling condition with several etiologies and clinical onsets. Identifying the underlying causes and individual risk factors is critical to determine prognosis and guide treatment.</p><p><strong>Objective: </strong>To analyze factors associated with III CN palsy, estimate recovery rates across different etiologies, and identify independent predictors of recovery, considering patient characteristics and comorbidities.</p><p><strong>Methods: </strong>A retrospective study was performed, including demographics and neurological data of a consecutive series of patients affected by III CN palsy from 2010 onwards. All patients underwent neurological examination, routine neuroimaging, and follow-up. Kaplan-Meier curve and the log-rank method were used to estimate recovery rates by etiology. Univariate and multivariate logistic regressions assessed patient-specific factors as independent predictors of recovery. Statistical significance was fixed as <i>p</i>-value < 0.05.</p><p><strong>Results: </strong>Overall, 50 patients were included. The prevailing causative factors were microangiopathy in 36% and miscellaneous in 36% of cases. Hypertension (50%), diabetes mellitus (34%), and cardiovascular diseases (14%) were the predominant comorbidities. Total recovery of the oculomotor function was found in 46% of patients. Kaplan-Meier analysis reported microangiopathy and syndromes as etiological factors significantly related to early recovery time. Age and pupillary involvement emerged as significant independent prognostic factors.</p><p><strong>Conclusion: </strong>The etiology significantly influences the recovery estimates of the oculomotor function. At the same time, patients' age, pupillary involvement, and especially hypertension as a comorbidity were the main predictive factors of good outcomes. More extensive studies are required to confirm these findings and include then in clinical practice.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lost in translation: why pharmacological trials keep failing in acute spinal cord injury.","authors":"Abelardo Q C Araujo","doi":"10.1055/s-0046-1827054","DOIUrl":"10.1055/s-0046-1827054","url":null,"abstract":"<p><strong>Abstract: </strong>Despite four decades of translational research, no pharmacological agent has been approved for acute traumatic spinal cord injury (SCI) based on class-I evidence. The current narrative review critically examines the seven agents evaluated in phase-II to -III clinical trials-methylprednisolone (MPSS), GM-1 monosialotetrahexosylganglioside, minocycline, riluzole, anti-Nogo-A antibody NG101, VX-210, and granulocyte colony-stimulating factor (G-CSF)-with emphasis on quantitative effect estimates, confidence intervals, and mechanisms of translational failure. Polylaminin, under phase-I evaluation approved by the Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária, ANVISA, in Portuguese), is discussed in the context of disproportionate public communication relative to the stage of evidence; available human data are limited to a small, uncontrolled, unreviewed pilot study insufficient for efficacy inferences. High-dose MPSS conferred no motor recovery benefit in a meta-analysis of 1,863 participants and was significantly associated with gastrointestinal hemorrhage (odds ratio [OR] = 2.07; 95%CI: 1.02-4.20) and respiratory infections (OR = 1.73; 95%CI: 1.12-2.68). Furthermore, GM-1 ganglioside, G-CSF, and VX-210 failed to meet the prespecified primary endpoints. Minocycline produced inconclusive results in an underpowered phase-II study. Riluzole (Riluzole in Spinal Cord Injury Study [RISCIS]), which was prematurely terminated at 55% of enrollment due to the coronavirus disease 2019 (COVID-19) pandemic, showed a significant motor benefit in patients classified as grade C according to the American Spinal Injury Association (ASIA) Impairment Scale (AIS) (+8.0 points; 95%CI: 1.5-14.4; 2-tailed <i>p</i> = 0.034). The Nogo Inhibition in Spinal Cord Injury (NISCI) trial (2025), the most methodologically rigorous SCI trial to date, demonstrated no primary endpoint benefit but identified functional signals in motor-incomplete injuries. In total, six structural domains of translational failure are identified and methodological solutions proposed.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral small vessel disease: pearls and pitfalls from unexplored risk factors to treatment.","authors":"Letícia Escorse Requião, Armando da Silva Rosa, Silvana Silva Macedo, Yasmin Curi de Almeida, Trajano Aguiar Pires Gonçalves, Iago Blanco Bacchiega, Rui Kleber do Vale Martins Filho, Maria Clara Zanon Zotin, Octávio Marques Pontes Neto","doi":"10.1055/s-0046-1829036","DOIUrl":"10.1055/s-0046-1829036","url":null,"abstract":"<p><strong>Abstract: </strong>Cerebral small vessel disease (CSVD) is a major cause of ischemic stroke and cognitive impairment, often accompanied by gait disturbances and neuropsychiatric symptoms that remain underrecognized. Age and hypertension are key risk factors, but emerging evidence points to the influence of genetic polymorphisms and clonal hematopoieses. The pathophysiology of CSVD is closely linked to neuroimaging features, as outlined in the Standards for Reporting Vascular changes on neuroimaging (STRIVE) criteria, which reflect the two most prevalent mechanisms: arteriosclerosis and cerebral amyloid angiopathy. As a clinico-radiological syndrome, CSVD encompasses imaging and histopathological findings. Despite its burden on function and quality of life, treatment remains limited to risk factor control. Ongoing studies aim to clarify the underlying mechanisms, validate biomarkers and identify novel therapeutic targets.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploding head syndrome's clinical features and an evaluation of polysomnographic findings.","authors":"Kübra Mehel Metin, Selda Keskin Güler, Sinan Yetkin, Tahir Kurtuluş Yoldaş","doi":"10.1055/s-0046-1825765","DOIUrl":"10.1055/s-0046-1825765","url":null,"abstract":"<p><strong>Background: </strong>Exploding head syndrome (EHS) is defined by the sudden onset of a short-term loud sounds or explosion-like sensation in the head during sleep, or sleep-wake transitions.</p><p><strong>Objective: </strong>To evaluate the clinical characteristics and polysomnographic (PSG) findings of patients diagnosed with EHS.</p><p><strong>Methods: </strong>The files of patients with an EHS diagnosis were retrospectively examined. Patients' clinical characteristics; PGS data; and results from the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI) and Beck Depression and Anxiety Inventory were evaluated. Also, PSG findings were compared with control group data.</p><p><strong>Results: </strong>In total, 26 patients with EHS and 22 healthy controls were included in our study. The 16 patients who underwent PSG testing and the control group were similar in terms of age and gender. The total sleep time (<i>p</i> = 0.001), sleep efficiency (<i>p</i> < 0.001), and rapid eye movement (REM) percentage (<i>p</i> = 0.019) were significantly lower in the patient group. The sleep latency (<i>p</i> = 0.001), wakefulness after sleep onset (<i>p</i> = 0.001), N1 percentage (<i>p</i> = 0.010), and PSQI score (<i>p</i> = 0.016) were significantly higher in the EHS group. Furthermore, 96% of the patients reported stress, and 84% of the patients had difficulties falling asleep.</p><p><strong>Conclusion: </strong>In this study the features of EHS are characterized and insomnia patterns emerge from PSG data. Examination with PSG should be considered in the presence of sleep disorders that disrupt sleep continuity. Patients' awareness about EHS should be increased, and people should be educated on taking sleep hygiene measures to strengthen sleep structure.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13387871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A map of neurology medical residency in Brazil in 2025: really a nation?","authors":"Rairis B Nascimento","doi":"10.1055/s-0046-1827162","DOIUrl":"10.1055/s-0046-1827162","url":null,"abstract":"<p><strong>Background: </strong>Neurology is a medical specialty that involves the study of various pathologies recognized for their high prevalence, morbidity and mortality. To keep up with this epidemiological scenario, we need adequately-trained professionals, whose academic training has its fundamental stage in medical residency.</p><p><strong>Objective: </strong>To characterize the existing medical residency programs (MRPs) in Neurology in Brazil in 2025, considering the availability of positions and the distribution of services throughout the country.</p><p><strong>Methods: </strong>An active search was conducted for MRP announcements for 2025 using advanced online search tools between October 2024 and March 2025. The list of medical residencies and specializations available on the website of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN, in Portuguese) was used as an initial reference.</p><p><strong>Results: </strong>A total of 50 calls for applications for Neurology for 2025 were evaluated, and 332 vacancies were found, offered by 101 different programs throughout Brazil. Overall, 51.81% of the vacancies (172 positions) were concentrated in the Southeastern region, with 30.72% (102 positions) located in the state of São Paulo. In total, 5 (18,52%) Brazilian states (Acre, Amapá, Rondônia, Roraima, and Tocantins), all in the Northern region, do not offer a Neurology MRP.</p><p><strong>Conclusion: </strong>An unequal distribution of medical residency vacancies in Neurology in Brazil is evident, and this pattern converges with other realities of medicine in the country, repeating current patterns of distribution of physicians and neurologists.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-4"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to think of genetic causes for rhabdomyolysis? A Brazilian single-center exploratory study.","authors":"Aldrin Pedroza Martins, Alberto Rolim Muro Martinez, Anamarli Nucci, Marcondes Cavalcante França Júnior","doi":"10.1055/s-0046-1827166","DOIUrl":"10.1055/s-0046-1827166","url":null,"abstract":"<p><strong>Background: </strong>Rhabdomyolysis is a potentially life-threatening condition that can result from genetic causes. Despite that, little is known about the genetic underpinnings behind monogenic rhabdomyolysis in Brazil.</p><p><strong>Objective: </strong>To address the frequency and predictive factors for monogenic causes of rhabdomyolysis in a Brazilian series.</p><p><strong>Methods: </strong>Patients presenting with rhabdomyolysis at Universidade Estadual de Campinas (UNICAMP) from April 2024 to October 2025 were selected. Rhabdomyolysis was defined when (1) there was at least 1 episode of creatine kinase (CK) levels ≥ 5x upper limit of normal (ULN) not better explained by exogeneous factors and (2) at least 1 of the RHABDO criteria (R - recurrent episodes of exertional rhabdomyolysis; H - hyperCKemia persisting more than 8 weeks after event; A: accustomed physical exercise; B - blood creatine kinase (CK) > 50x ULN; D - drug ingestion/medication/supplements or other exogenous and endogenous factors cannot sufficiently explain the rhabdomyolysis severity; O - other family members affected / other exertional symptoms [e.g., cramps or myalgia]). was met. A 2-step genetic investigation was undertaken: first a 50-gene panel enriched in metabolic myopathy genes and for those with negative results, whole exome sequencing (WES). Clinical and demographic data of patients with and without gene etiology were then compared.</p><p><strong>Results: </strong>We identified 20 patients, 8 of whom were men, with mean age at the first episode of rhabdomyolysis of 19.5 (2-50) years old. Monogenic etiology was found in 9 of the patients. The associated genes were <i>PYGM</i> (most frequent), <i>CPT II</i>, <i>ACADS</i>, <i>ACADM</i>, <i>ANO5</i>, <i>DYSF</i> and <i>FKTN</i>. Creatine kinase ≥ 5x ULN persisting for more than 8 weeks after the event (<i>p</i> = 0.0081), myalgia (<i>p</i> 0.028), objective weakness (<i>p</i> = 0.049) and parental consanguinity (<i>p</i> = 0.0090) were more frequent in the group with genetic cause.</p><p><strong>Conclusion: </strong>After properly exclusion of exogenous etiologies, monogenic causes accounted for nearly half of the cases of rhabdomyolysis. Genetic testing should be pursued in those patients with persistent CK elevation, presence of myalgia, objective weakness or parental consanguinity.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging role of high-intensity focused ultrasound (HIFU) as a symptomatic treatment for Parkinson's disease and essential tremor: a narrative review.","authors":"Karina Silveira Massruha, Ananda Carolina Moraes de Falcone, Isadora Santos Ferreira, Jacy Bezerra Parmera, Polyana Vulcano de Toledo Piza, Rodrigo Gobbo Garcia, Ellison Fernando Cardoso, Luis Filipe de Souza Godoy, Stephany Tueini Toogood, Anna Verena de Carvalho Leite, Rubens Gisbert Cury","doi":"10.1055/s-0046-1827056","DOIUrl":"10.1055/s-0046-1827056","url":null,"abstract":"<p><strong>Abstract: </strong>The high-intensity focused ultrasound (HIFU) technique has become precise, incisionless, and ablative for treating essential tremor (ET) and Parkinson's disease (PD), driven by advances in magnetic resonance imaging (MRI) thermometry and tractography. The current review integrates the main clinical outcomes associated with established and emerging HIFU targets, synthesizing efficacy data, adverse effect (AE) patterns, and procedural characteristics relevant to clinical decision-making. In ET, ventral intermediate nucleus (VIM) thalamotomy results in tremor reductions ranging from 56 to 81%, with a long-term sustained benefit of approximately 73%. In tremor-dominant PD (TdPD), VIM ablation achieves tremor suppression of approximately 62%. Comparatively, HIFU-guided subthalamotomy provides broader motor benefits, with 53 to 57.8% improvement in the Movement Disorder Society's Unified Parkinson's Disease Rating Scale, Part III (MDS-UPDRS III), as well as significant reductions in rigidity and bradykinesia. Pallidotomy improves \"off\" state motor symptoms and dyskinesias, whereas pallidothalamic tractotomy leads to 52% global motor improvement and 91% tremor reduction. The AEs vary according to the targets. In VIM procedures, gait imbalance (16-40%) and sensory disturbances (9-26%) predominate, along with dysarthria and dysmetria. Lesions to the subthalamic nucleus (STN) are most commonly associated with dysarthria (10-26%) and gait instability (15-48%). Procedures targeting the globus pallidus internus (GPi) or pallidothalamic tract (PTT) may also present with gait instability or dysarthria, which are generally mild and transient. Although the SDR has historically limited eligibility, recent evidence demonstrates that patients with SDR ≤ 0.40 may still experience meaningful improvement, supporting more individualized selection. In the current therapeutic landscape, HIFU offers immediate clinical benefits, absence of implanted hardware, and simplified recovery, positioning it as an alternative or complementary therapy to deep brain stimulation (DBS).</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinson's disease-associated psychosis in a Brazilian sample: prevalence and clinical profile.","authors":"Henrique Nascimento Dourado, Isabelle Jacqueline Weber Oliveira, Camila Caroso Lobo, Gustavo Cavalcante Procópio, Ana Emanuela Coelho Pessoa Lima, Guilherme Teixeira Valença","doi":"10.1055/s-0046-1829035","DOIUrl":"10.1055/s-0046-1829035","url":null,"abstract":"<p><strong>Background: </strong>Psychosis is a frequent and disabling non-motor complication of Parkinson's disease (PD). Reported prevalence varies widely, and data in Brazilian cohorts remain scarce.</p><p><strong>Objective: </strong>To estimate the prevalence of PD-associated psychosis (PDP) in a Brazilian cohort and to describe its sociodemographic and clinical profile.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in a Brazilian movement disorders outpatient clinic between May and December of 2022. Adult patients with idiopathic PD defined by the United Kingdom's Parkinson's Disease Society Brain Bank criteria were consecutively evaluated. Sociodemographic and clinical variables were collected. Psychosis was assessed using the diagnosis criteria proposed by the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health (NINDS/NIMH) and graded with the Movement Disorders Society's Unified PD Rating Scale (MDS-UPDRS). Cognitive screening was performed using the Mini-Mental State Examination (MMSE), and disease severity was assessed with the modified Hoehn & Yahr scale (mH&Y). Neuropsychiatric symptoms were evaluated with the Neuropsychiatric Inventory Questionnaire (NPI-Q). Descriptive analyses and exploratory univariate comparisons were performed.</p><p><strong>Results: </strong>In total, 75 patients were included. The median age was 68 years (IQR: 59.5-74.5), and the mean age at PD onset was 56.0 ±  9.8 years. Median disease duration was 10 years (IQR: 6-14.5). Most patients were male (54.7%) and self-identified as Mixed-race (48.6%) or Black (31.1%). According to the mH&Y scale, 82.7% had mild-to-moderate disease. Furthermore, PDP was diagnosed in 18 patients (24%) according to NINDS/NIMH criteria. Minor phenomena and hallucinations were the most frequent psychotic manifestations, each occurring in 72.2% of PDP cases.</p><p><strong>Conclusion: </strong>In this Brazilian cohort, PDP had a prevalence of 24%. These findings reinforce that psychosis is a frequent non-motor manifestation of PD and highlight the importance of systematic clinical screening in routine care.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter on: \"Assessment of heart rate variability and occurrence of falls in Alzheimer's disease: an exploratory study\".","authors":"Etika Rana, Sanam Maurya","doi":"10.1055/s-0046-1827045","DOIUrl":"10.1055/s-0046-1827045","url":null,"abstract":"","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-2"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arquivos de Neuro-Psiquiatria, 80 years: part 3 (1983-2002).","authors":"Caio Levi Mendes Costa, Gabriel Ramos de Oliveira Gondim, Emanuela Freire Caetano Davi, Nayana Freire de Almeida Fontes, Bernardo de Gusmão Baumflek Baptista, Thais Graniço Baumflek, Francisco de Assis Aquino Gondim","doi":"10.1055/s-0046-1827065","DOIUrl":"10.1055/s-0046-1827065","url":null,"abstract":"<p><strong>Background: </strong>Arquivos de Neuro-Psiquiatria (ANP) celebrated 80 years in 2023. We have previously evaluated the publication trends throughout the journal's first 40 years.</p><p><strong>Objective: </strong>To analyze the publication trends, authorship, and editorial patterns of the volumes 41 to 60 of ANP.</p><p><strong>Methods: </strong>We analyzed the volumes 41 to 60 of ANP (1983-2002). Data were tabulated independently by five blinded researchers and crossverified by two independent researchers.</p><p><strong>Results: </strong>From 1983 to 2002, 20 volumes, 91 issues and 2,424 articles were published. We analyzed 2,066 articles after excluding nonresearch papers (1,159 original articles and 770 case reports). Compared with the first 20 years, there was a significant increase in the total number of authors/article (3.96 vs. 2.73, <i>p</i> < 0.00001), a significant increase of female authors, from 11 to 28.6% (<i>p</i> < 0.05), and a decrease in the number of pages/article (<i>p</i> < 0.05). Lineu Cesar Werneck, Hélio Afonso Ghizoni Teive, and Milberto Scaff were the most prolific authors. Most of the articles focused on Neurology/Child Neurology subjects, with a progressive decreased percentage of Psychiatry papers and increase in Basic Research contributions. There was a linear increase in the total number of articles from 1983 to 2002 as detected by regression analysis (R² = 0.9134; <i>p</i> < 0.0001) and an exponential increase from 1943 to 2002 (R² = 0.9046; <i>p</i> < 0.0001). Most of the articles were written in Brazilian Portuguese, by authors from Southeastern Brazil (60.2%).</p><p><strong>Conclusion: </strong>The years 1983 to 2002 marked the transition to the current ANP format: minimal Psychiatry contributions; greater contribution from Southern Brazilian states; and, starting in 1999, greater acknowledgment of sponsorship from research agencies and postgraduate training.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 8","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}