Arquivos de neuro-psiquiatria最新文献_第4页

Association between the levels of gamma-glutamyl transpeptidase and the risk of stroke: systematic review and meta-analysis. -谷氨酰转肽酶水平与卒中风险之间的关系：系统回顾和荟萃分析。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-07-15 DOI: 10.1055/s-0045-1809936

Gustavo Adolfo Vásquez-Tirado, Stefany M Nieto-Rivera, Claudia Vanessa Quispe-Castañeda, Edinson Dante Meregildo-Rodríguez, Leslie Jacqueline Liñán-Díaz, Wilson Marcial Guzmán-Aguilar

{"title":"Association between the levels of gamma-glutamyl transpeptidase and the risk of stroke: systematic review and meta-analysis.","authors":"Gustavo Adolfo Vásquez-Tirado, Stefany M Nieto-Rivera, Claudia Vanessa Quispe-Castañeda, Edinson Dante Meregildo-Rodríguez, Leslie Jacqueline Liñán-Díaz, Wilson Marcial Guzmán-Aguilar","doi":"10.1055/s-0045-1809936","DOIUrl":"10.1055/s-0045-1809936","url":null,"abstract":"Stroke is influenced by numerous factors, both modifiable and non-modifiable. Among these, gamma-glutamyl transpeptidase (GGT) serves as a prognostic biomarker in cardiovascular diseases and, within this context, in neurological conditions like stroke.To determine whether an association exists between GGT and both ischemic and hemorrhagic strokes.A systematic and comprehensive literature search was conducted across 5 databases, encompassing studies published from their inception to January 28, 2024, following a population, exposure, comparator, outcome, and study (PECOS) framework. Ten primary studies meeting the eligibility criteria were selected.Our findings, based on a meta-analysis of the ten studies, indicate an increased risk of ischemic and hemorrhagic strokes in patients with elevated GGT levels, after excluding outliers. The analysis demonstrated a significant association, with a relative risk of 1.42 (95%CI: 1.01-1.99; I2 = 19%) for hemorrhagic stroke and 1.22 (95%CI: 1.10-1.36; I2 = 49%) for ischemic stroke.Our study reveals an elevated risk of stroke in patients with high GGT levels, demonstrating a 42% higher likelihood of hemorrhagic stroke and a 22% increased risk of ischemic stroke.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 7","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active tuberculosis and multiple sclerosis: the importance of screening before treatment. 活动性肺结核与多发性硬化：治疗前筛查的重要性。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-08-04 DOI: 10.1055/s-0045-1810406

Leizian de Souza Amorim, Paloma Peter Travassos Zaidan, Felipe Toscano Lins de Menezes, Enedina Maria Lobato de Oliveira

{"title":"Active tuberculosis and multiple sclerosis: the importance of screening before treatment.","authors":"Leizian de Souza Amorim, Paloma Peter Travassos Zaidan, Felipe Toscano Lins de Menezes, Enedina Maria Lobato de Oliveira","doi":"10.1055/s-0045-1810406","DOIUrl":"10.1055/s-0045-1810406","url":null,"abstract":"Tuberculosis (TB), a chronic infection caused by the Mycobacterium tuberculosis complex, has an increased risk of reactivation in conditions that affect the immune system, such as MS, and its treatment with disease-modifying drugs (DMDs). The present is a retrospective study of 2,036 patients diagnosed with MS followed at the Department of Neurology and Neurosurgery of Escola Paulista de Medicina, Universidade Federal de São Paulo, from February 1994 to September 2023. Of that total, 6 were included in this case series, taking different DMDs: fingolimod (n = 2), interferon beta 1a (n = 2), glatiramer acetate (n = 1) and cyclophosphamide (n = 1). In our study, two patients experienced worsening disability during tuberculosis treatment, while three others had increased disability after completing treatment. We reinforce the importance of screening all patients eligible for DMD treatment, especially the highly effective modern ones, and the importance of developing research-based guidelines for screening infectious diseases among patients with MS.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 7","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Headaches in juvenile systemic lupus erythematosus patients: a cross-sectional study. 青少年系统性红斑狼疮患者的头痛：一项横断面研究。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-08-04 DOI: 10.1055/s-0045-1810407

Bryan Silva Marques Cajado, Renata Lopes Francisco Andrade, Maria Angelina Carvalho Pereira, Marcelo Melo Aragão, Maria Teresa Terreri

{"title":"Headaches in juvenile systemic lupus erythematosus patients: a cross-sectional study.","authors":"Bryan Silva Marques Cajado, Renata Lopes Francisco Andrade, Maria Angelina Carvalho Pereira, Marcelo Melo Aragão, Maria Teresa Terreri","doi":"10.1055/s-0045-1810407","DOIUrl":"10.1055/s-0045-1810407","url":null,"abstract":"Juvenile systemic lupus erythematosus (jSLE) often involves the central nervous system, with headache being the most common symptom.To describe the frequency, characteristics, and impact on quality of life of headaches in jSLE patients.We conducted a cross-sectional study with jSLE patients under the age of 19 years through chart reviews and questionnaires. The participants underwent clinical and neurological exams, assessments of disease activity and damage, and evaluations of headache characteristics. Quality-of-life impacts were measured using the Brazilian Portuguese version of the Pediatric Quality of Life Inventory (PedsQL), and cognitive function was assessed with the Mini-Mental State Examination.Out of 34 patients enrolled, 17 presented with headaches (which were more prevalent in female subjects). The age of the patients at the time of the evaluation ranged from 8 to 18 years, and the mean age at headache onset was of 11.3 years. Most participants with headaches reported having episodic headaches (76.5%), no perimenstrual crises (73.3%), and a family history of migraines (88.2%). Additionally, most patients reported physical activity (35.3%) and stress (58.8%) as triggers. Patients with headaches had significantly lower PedsQL scores compared with those without headaches, both in health and activities (61.76 versus 73.71 respectively; p = 0.04) and feelings (42.65 versus 60.35 respectively; p = 0.049).Headaches were more prevalent in female jSLE patients, and the most subjects experienced migraines as the primary cause of headache. Patients with headaches presented lower scores on quality-of-life questionnaires. These findings highlight the need for a comprehensive approach to headache management in jSLE to enhance patient well-being.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 7","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The best of both worlds: deep brain stimulation or high-frequency focused ultrasound for tremor refractory syndromes. 两者兼而有之：深部脑刺激或高频聚焦超声治疗震颤难治性综合征。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 DOI: 10.1055/s-0045-1808084

Carina França, Rubens Gisbert Cury

引用次数: 0

Practical issues in the management of sleep, anxiety, and mood disorders in primary headaches. 原发性头痛患者睡眠、焦虑和情绪障碍管理的实际问题。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1055/s-0045-1809881

Patrick Emanuell Mesquita Sousa-Santos, Mario Fernando Prieto Peres

引用次数: 0

Clinical characterization, natural history, and neuroimaging of cerebellar ataxia after abdominal surgery. 腹部手术后小脑性共济失调的临床特征、自然病史和神经影像学。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-07-15 DOI: 10.1055/s-0045-1809934

Victor Rebelo Procaci, Thiago Yoshinaga Tonholo Silva, Raphael Pinheiro Camurugy da Hora, Orlando Graziani Povoas Barsottini, José Luiz Pedroso

{"title":"Clinical characterization, natural history, and neuroimaging of cerebellar ataxia after abdominal surgery.","authors":"Victor Rebelo Procaci, Thiago Yoshinaga Tonholo Silva, Raphael Pinheiro Camurugy da Hora, Orlando Graziani Povoas Barsottini, José Luiz Pedroso","doi":"10.1055/s-0045-1809934","DOIUrl":"10.1055/s-0045-1809934","url":null,"abstract":"The rates of complications after major abdominal surgeries remain high, despite the advances in pre- and postoperative care and surgical techniques. In these cases, neurological disorders mainly include stroke and delirium, with a high increase of morbidity. Ataxia is rarely a consequence of abdominal procedures like, more often being related to long-term complications of bariatric surgery due to chronic vitamin deficiency.To describe seven cases of ataxia following major abdominal surgeries and propose a prophylactic approach.A retrospective case series in which medical records of patients from the Ataxia Unit of Universidade Federal de São Paulo were evaluated from January 2007 to August 2024. We identified seven patients who developed acute cerebellar ataxia after gastrointestinal surgery. Demographic, clinical, laboratory, neuroimaging, and treatment data were extracted. Descriptive statistics was used to summarize findings.There were two cases that evolved with neurological improvement, and five remained with severe cerebellar ataxia. Brain imaging showed cerebellar atrophy in three patients and signs of Wernicke encephalopathy in two.This case series describes an unusual form of acute ataxia with poor outcomes, possibly related to complications from major abdominal surgery. Early intervention and prophylactic supplementation with vitamins B1 and B12 in patients receiving TPN should be considered to avoid such severe neurological complications.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 7","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

40 years of CEPARM: transforming amyloidosis related to transthyretin from neglect to recognition. 40年的CEPARM：将甲状腺转甲状腺素相关淀粉样变性从忽视转变为认识。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-06-20 DOI: 10.1055/s-0045-1809401

Marcia Waddington Cruz, Marleide da Mota Gomes

引用次数: 0

Magnetic resonance imaging in the diagnosis of HTLV-1-associated myelopathy. 磁共振成像在htlv -1相关性脊髓病诊断中的应用。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.1055/s-0045-1809935

João Marcos Carvalho, Sheila Nunes Ferraz, José Abraão Neto, Saul Schnitman, Augusto M Carvalho, Edgar M Carvalho

{"title":"Magnetic resonance imaging in the diagnosis of HTLV-1-associated myelopathy.","authors":"João Marcos Carvalho, Sheila Nunes Ferraz, José Abraão Neto, Saul Schnitman, Augusto M Carvalho, Edgar M Carvalho","doi":"10.1055/s-0045-1809935","DOIUrl":"10.1055/s-0045-1809935","url":null,"abstract":"The main neurologic manifestation of definitive human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy (HAM) is spastic paraparesis, but it only occurs in 5% of the patients. In contrast, about 40% of HTLV-1-infected subjects present symptoms of urologic dysfunction, including nocturia, urgency, and incontinence, which may progress to an inability to void urine. As these patients do not present motor dysfunction, they are classified as probable HAM. Atrophy of the thoracic spinal cord (SC) is the main abnormality found on magnetic resonance image (MRI) scans of patients with definitive HAM, but damage to the SC has not been reported in patients with probable HAM.To determine if, through an evaluation of the metrics of conventional MRI, we can detect a decrease in the area of the SC in patients with probable HAM.Infection by HTLV-1 was herein diagnosed by a Western blot, and the MRI scan was performed using a 1.5-T scanner. Atrophy was considered when the SC area was less than 25% of the intrathecal area.We observed a progressive reduction in all segments of the SC area among HTLV-1 carriers, patients with probable and definitive HAM. Significantly, 48.3% of patients with probable HAM presented atrophy of the lumbar area.Using MRI metrics, the present study shows the atrophy of lumbar segments of the SC area in patients who present urinary symptoms associated with HTLV-1 but without motor dysfunction.","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"83 7","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误表。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-08-25 DOI: 10.1055/s-0045-1809947

引用次数: 0

Conventional MRI's diagnostic role in HTLV-1-associated myelopathy reframed. 传统MRI在htlv -1相关脊髓病中的诊断作用被重新定义。

IF 1.6 4区医学

Arquivos de neuro-psiquiatria Pub Date : 2025-07-01 Epub Date: 2025-08-15 DOI: 10.1055/s-0045-1811520

Abelardo Q C Araújo

引用次数: 0