Brain activity and autonomic regulation in untreated migraine patients.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Arquivos de neuro-psiquiatria Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI:10.1055/s-0045-1808085

Isabel Oliveira Monteiro, Juliana Novakovic, Miguel K Rodrigues, Joel S Cunha Neto, Maíra O V Rela, Mayron F Oliveira

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引用次数: 0

Abstract

Migraine causes intense pain, significant disability, deficits in attention and memory, slowed information processing, and cognitive disorders. However, it is unclear how migraine, cardiovascular, and cerebral issues impact daily life or relate to future adverse events.To evaluate the brain activity and autonomic regulation in untreated migraine patients.In the present case-control study, we compared untreated migraine patients with healthy controls. The participants underwent cognitive testing (Stroop Color Test, Trail Making Test, Addenbrooke's Cognitive Examination, and Reaction Time Test), brain activity measurement (MindWave Mobile), and autonomic regulation assessment via heart rate variability (Polar V800).No differences were found between the groups in terms of cognitive test scores. However, the healthy controls consistently showed increased variation in brain activity during the cognitive tests, while migraine patients exhibited decreased activity across all tests (p < 0.05). During the Stroop Color Test, the controls showed a positive change in brain activity (Δ = 5.12 ± 3.64) while the migraine patients showed a negative change (Δ = -5.41 ± 2.21). In addition, the control group demonstrated a normal autonomic response, with increased sympathetic activity (low-frequency [LF] band: 70.2-84.4 Hz) and decreased parasympathetic activity (high-frequency [HF] band: 29.6-15.6 Hz) during cognitive tasks (p < 0.05). In contrast, the migraine group showed imbalanced autonomic regulation, characterized by minimal changes in both sympathetic (LF band: 74.0-74.8 Hz) and parasympathetic activity (HF band: 25.9-25.1 Hz) (p > 0.05).Despite the similar cognitive test scores, migraine patients exhibited reduced variation in brain activity during cognitive tests and an imbalanced autonomic regulation, characterized by decreased sympathetic activity and increased parasympathetic activity.

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未经治疗的偏头痛患者的脑活动和自主神经调节。

偏头痛会导致剧烈疼痛、严重残疾、注意力和记忆力减退、信息处理速度减慢和认知障碍。然而，目前尚不清楚偏头痛、心血管和大脑问题如何影响日常生活或与未来的不良事件有关。评估未经治疗的偏头痛患者的脑活动和自主神经调节。在本病例对照研究中，我们比较了未经治疗的偏头痛患者和健康对照者。参与者进行了认知测试（Stroop Color Test, Trail Making Test, Addenbrooke’s cognitive Examination, and Reaction Time Test），脑活动测量（MindWave Mobile），以及通过心率变异性进行自主调节评估（Polar V800）。在认知测试分数方面，两组之间没有发现差异。然而，健康对照组在认知测试中一致显示出大脑活动增加的变化，而偏头痛患者在所有测试中都表现出活动减少（p p p > 0.05）。尽管认知测试得分相似，但偏头痛患者在认知测试中表现出大脑活动变化减少和自主神经调节不平衡，其特征是交感神经活动减少和副交感神经活动增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de neuro-psiquiatria 医学-精神病学

CiteScore

2.10

自引率

7.10%

发文量

262

审稿时长

4-8 weeks

期刊介绍： Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology. The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.