Australian Veterinary Journal最新文献

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Time course of clinical signs and mortality in dogs with severe perioperative acute kidney injury: A scoping review 围手术期严重急性肾损伤犬的临床症状和死亡率的时间过程:范围综述。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-05-27 DOI: 10.1111/avj.13454
C.T. Quinn
{"title":"Time course of clinical signs and mortality in dogs with severe perioperative acute kidney injury: A scoping review","authors":"C.T. Quinn","doi":"10.1111/avj.13454","DOIUrl":"10.1111/avj.13454","url":null,"abstract":"<p>Perioperative acute kidney injury (AKI) is a potential cause of anaesthetic mortality in dogs. The time delay between anaesthetic recovery, onset of clinical signs and any subsequent mortality may result in under-recognition of this complication. This review aimed to explore the literature reporting dogs with severe AKI after general anaesthesia and surgery. Firstly, to determine the time course between anaesthesia recovery and onset of clinical signs, and between recovery and any mortality. Secondly, to identify the common clinical signs and signalment of dogs with perioperative AKI. PubMed and CAB abstracts data bases using the terms “(acute kidney injury OR acute renal failure) AND dog AND (anaesthesia OR surgery)”; and ResearchRabbit were searched. Peer reviewed publications in English describing dogs that developed AKI with overt clinical signs after anaesthesia were included. Number of postoperative days until onset of clinical signs and death; along with signalment and the reported clinical signs leading to AKI diagnosis were extracted. Nine publications describing a total of 31 dogs were included in the review. Clinical signs were typically first seen 2–4 days postoperatively (range 1–14). Death/euthanasia occurred in 5 dogs; between 3 and 60 days postoperatively. Persistent renal dysfunction occurred in 4 survivors. The most common clinical signs were anorexia, lethargy, polyuria/polydipsia and vomiting. Female and larger breed dogs especially Labradors and Golden Retrievers were overrepresented. Knowledge of this time course may improve postoperative monitoring and recognition of perioperative AKI in dogs.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 7","pages":"443-449"},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13454","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors related to resilience for mid- to late-career-stage veterinarians: a qualitative study 职业生涯中后期兽医心理弹性的相关因素:一项定性研究。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-05-22 DOI: 10.1111/avj.13453
IF van Gelderen, SM Matthew, ML McArthur
{"title":"Factors related to resilience for mid- to late-career-stage veterinarians: a qualitative study","authors":"IF van Gelderen,&nbsp;SM Matthew,&nbsp;ML McArthur","doi":"10.1111/avj.13453","DOIUrl":"10.1111/avj.13453","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to explore how resilience in mid- to late-career stage veterinarians in Australia is shaped by interactions between job demands, personal and contextual resources, strategies and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Semistructured interviews with 17 mid- to late-career stage veterinarians were conducted with questions modelled on prior research investigating veterinarians' experiences, teacher well-being and resilience. The Job Demands-Resources model guided thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mid- to late-career stage veterinarians described how resilience is shaped by interactions between (1) demands of the job, (2) resources available, (3) strategies used and (4) resilience outcomes. Job demands and job resources categories were sub-divided into four and seven themes respectively according to whether characteristics were based on personal or contextual factors. Strategies were grouped into seven themes representing intentional ways that veterinarians made effective use of resources. Three themes in the Outcomes category represented positive outcomes that were enabled through dynamic interaction between demands, resources and strategies undertaken to realise outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>This study did not explore relationships between perceptions of resilience and veterinary work type, practice location, age or gender. Interviews were conducted before the global COVID-19 pandemic, and results do not reflect any associated psychological impacts from that event.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Resilience in mid- to late-career veterinarians is a dynamic process driven by the interplay of demands, resources, intentional actions and outcomes. Although personal resources can be developed over time, job demands are largely contextual. Effective management practices can mitigate challenges and foster resilience.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 7","pages":"388-400"},"PeriodicalIF":1.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inducing emesis in Australian dogs and cats: agents, adverse effects and antiemetic administration 诱发呕吐在澳大利亚狗和猫:代理人,不良反应和止吐管理。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-05-06 DOI: 10.1111/avj.13449
J Tsitonakis, E Hall, A Quain
{"title":"Inducing emesis in Australian dogs and cats: agents, adverse effects and antiemetic administration","authors":"J Tsitonakis,&nbsp;E Hall,&nbsp;A Quain","doi":"10.1111/avj.13449","DOIUrl":"10.1111/avj.13449","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe the agents used by Australian veterinarians in inducing emesis in dogs and cats, adverse effects and antiemetic administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An anonymous online mixed-methods survey incorporating closed and open-ended questions was distributed to Australian veterinarians via e-newsletters and social media between April and June 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 317 valid responses, 316 respondents induced emesis in a dog (99.7%) and 128 (40.4%) induced emesis in a cat in the previous 12 months. The most common protocols were subcutaneous injection of apomorphine (n = 310/316, 98.1%) for dogs and intramuscular injection of dexmedetomidine or medetomidine (n = 79/128, 61.7%) for cats. Respondents reported significantly reduced success (n = 74/128, 57.8%) inducing emesis in cats compared with dogs (n = 312/316, 98.7%) (P ≤ 0.001). Sedation was the most reported adverse effect for both species. The subconjunctival route of apomorphine was found to significantly increase the risk of adverse effects in dogs, compared with the subcutaneous route (P = 0.03). Antiemetics were more frequently administered to dogs than cats. Univariable logistical regression analysis revealed that veterinarians with fewer than 5 years' experience were significantly more likely to use an antiemetic drug when inducing vomiting in dogs (P = 0.05) compared with veterinarians with 31 or more years of experience.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings enable clinicians to benchmark practices against those of their peers, characterise adverse effects associated with emesis induction and refine their technique to improve patient welfare. A more reliable means of inducing emesis in cats is needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 7","pages":"433-442"},"PeriodicalIF":1.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of vector-borne pathogens Ehrlichia canis, Babesia spp. and Dirofilaria immitis in dogs in Townsville, far north Queensland 昆士兰州北部汤斯维尔市犬中媒介传播病原体犬埃利希体、巴贝斯虫和免疫迪罗丝虫的流行情况。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-05-04 DOI: 10.1111/avj.13450
K Gerber, JA Picard, J Elliman, CJ Joone, Y Indrawirawan, CC Constantinoiu
{"title":"Prevalence of vector-borne pathogens Ehrlichia canis, Babesia spp. and Dirofilaria immitis in dogs in Townsville, far north Queensland","authors":"K Gerber,&nbsp;JA Picard,&nbsp;J Elliman,&nbsp;CJ Joone,&nbsp;Y Indrawirawan,&nbsp;CC Constantinoiu","doi":"10.1111/avj.13450","DOIUrl":"10.1111/avj.13450","url":null,"abstract":"<p><i>Ehrlichia canis</i>, <i>Babesia</i> spp. and <i>Dirofilaria immitis</i> are blood-borne pathogens transmitted to dogs by arthropods. The aim of the current study was to investigate the prevalence of <i>E. canis</i>, <i>Babesia</i> spp. and <i>D. immitis</i> in domestic dogs, aged 6 months or older, in Townsville, in far north Queensland, Australia. Dogs were recruited through convenience sampling, with the assistance of local veterinary clinics and James Cook University staff and students. Up to 3 ml of blood was collected per dog, into EDTA vacutainer tubes. Testing for <i>E. canis</i> and <i>Babesia</i> spp. was performed through qPCR, with a second PCR used to identify the species in <i>Babesia</i>-positive cases. Testing for <i>D. immitis</i> was performed using a commercial antigen detection kit and the modified Knott's test (MKT); microfilariae identity was confirmed by morphological features and qPCR. Of 301 dogs sampled, none tested positive for <i>E. canis</i>, whereas 9 (3.0%, 95% CI 1.1–4.9%) tested positive for <i>Babesia vogeli</i>, and 15 (5.0%; 95% CI 2.5–7.5%) tested positive for <i>D. immitis</i>, based on the combined antigen and MKT results.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 7","pages":"430-432"},"PeriodicalIF":1.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracic radiographic findings of canine spirocercosis in Australia 澳大利亚犬螺旋体病的胸片表现。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-05-01 DOI: 10.1111/avj.13447
P Thong, B Hopper, G Tenni, Z Lenard
{"title":"Thoracic radiographic findings of canine spirocercosis in Australia","authors":"P Thong,&nbsp;B Hopper,&nbsp;G Tenni,&nbsp;Z Lenard","doi":"10.1111/avj.13447","DOIUrl":"10.1111/avj.13447","url":null,"abstract":"<p>Canine spirocercosis in Australia has been poorly described in the veterinary literature. The objectives of this multicentre retrospective case series were to increase the awareness of veterinarians (including teleradiology providers) regarding <i>Spirocerca lupi</i> in Australia and to describe the thoracic radiographic findings of dogs infected with <i>S. lupi</i> with comparison to other endemic regions. Fifty-nine dogs with a diagnosis of canine spirocercosis were recruited from veterinary practices located in subtropical and tropical Australia. Many (54/59; 92%) originated from Mount Isa, Queensland, due to proactive screening. Thoracic radiographs identified 42 oesophageal masses in 35/59 (59%) of affected dogs. Identification of oesophageal masses was nearly always facilitated by oesophageal gaseous distension after gastro-oesophageal endoscopy, sedation or anaesthesia (33/35, 94%). Oesophageal masses were most frequently centred at T8. Where the aorta was visualised, aortic enlargement was detected in 17/42 (40%) dogs. Spondylitis was frequently detected (32/59; 54%) and most frequently located at T8-11. Spondylosis deformans was less frequently detected (14/59; 24%) but in 7/14 (50%) studies it was present concurrently with spondylitis. Spondylitis had varied morphological features, some of which were contrary to previously reported definitions. Despite this, the radiographic appearance of spondylitis allowed relatively reliable differentiation from spondylosis deformans and added significant confidence to the radiographic diagnosis of spirocercosis. Pleural effusion (5/59; 8%) was the most frequent additional radiographic finding. In conclusion, thoracic radiographic findings of canine spirocercosis in Australia are similar to other endemic regions and <i>S. lupi</i> is present in multiple regions of Australia not previously reported.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 6","pages":"354-367"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing updated haematological and biochemical reference intervals for urban brushtail possums (Trichosurus vulpecula) in Australia 澳大利亚城市帚尾负鼠(Trichosurus vulpecula)最新血液学和生化参考区间的建立。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-04-21 DOI: 10.1111/avj.13444
C Marschner, A Geisler-Edge, Y Chao, N Courtman
{"title":"Establishing updated haematological and biochemical reference intervals for urban brushtail possums (Trichosurus vulpecula) in Australia","authors":"C Marschner,&nbsp;A Geisler-Edge,&nbsp;Y Chao,&nbsp;N Courtman","doi":"10.1111/avj.13444","DOIUrl":"10.1111/avj.13444","url":null,"abstract":"<p>Reference intervals (RIs) or reference ranges are crucial tools in clinical practice and research, aiding in the interpretation of laboratory test results by providing values expected in a healthy population. This paper provides haematology and biochemistry reference intervals and ranges established from a population of urban brushtail possums (<i>Trichosurus vulpecula</i>) captured for health assessment on Sydney University campus, Australia.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 7","pages":"411-415"},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pig carcass decomposition dynamics: Insights into carcass disposal for emergency animal disease management 猪胴体分解动力学:对紧急动物疾病管理的胴体处理的见解。
IF 1.7 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-04-20 DOI: 10.1111/avj.13440
O Schlosberg, BD Cowled, J Torpy, A Höger, RE Thompson, TS Barnes, K Richards, RN Hall, EEC Leslie
{"title":"Pig carcass decomposition dynamics: Insights into carcass disposal for emergency animal disease management","authors":"O Schlosberg,&nbsp;BD Cowled,&nbsp;J Torpy,&nbsp;A Höger,&nbsp;RE Thompson,&nbsp;TS Barnes,&nbsp;K Richards,&nbsp;RN Hall,&nbsp;EEC Leslie","doi":"10.1111/avj.13440","DOIUrl":"10.1111/avj.13440","url":null,"abstract":"<p>Australia is free from many economically devastating emergency animal diseases (EADs) that threaten livestock production in neighbouring countries. In Australia, an important consideration for EAD control is managing susceptible feral animal populations, especially in remote and inaccessible areas where carcass disposal poses considerable logistical challenges. One proposed solution is to utilise natural decomposition above ground through the ‘destroy and let lie’ (D&amp;LL) method, relying on post-mortem changes in carcass temperature and pH to inactivate the EAD agent. We investigated temperature and pH changes in pig carcasses from death until end-stage decomposition at two locations in Queensland to gain insights into how carcasses left <i>in situ</i> decompose under Australian conditions. Using regression modelling, we identified days since humane killing, air temperature, rainfall, relative humidity, anatomical site and study location as significant predictors of carcass pH and temperature. Although the observed carcass pH and temperature conditions did not meet African swine fever virus (ASFV) inactivation thresholds, foot-and-mouth disease virus (FMDV) was likely to be inactivated in the thoracic cavity, superficial and deep skeletal muscle and abdominal cavity of most carcasses. However, FMDV inactivation thresholds were not reached in bone marrow and brain. This suggests that these carcasses may potentially remain infectious with ASFV and FMDV <i>in situ</i> under the experimental conditions encountered, based on the inactivation thresholds selected. Despite this, culling large portions of a feral pig population, in conjunction with D&amp;LL disposal approach, may still support disease control imperatives during an EAD response by reducing live pig numbers and disease transmission.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 9","pages":"542-558"},"PeriodicalIF":1.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brucella suis in feral pigs in Australia: what is the risk? 澳大利亚野猪感染猪布鲁氏菌的风险是什么?
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-04-20 DOI: 10.1111/avj.13441
CC Kneipp, D Marshall, ME Westman, R Malik, MA Stevenson, SM Mor, AK Wiethoelter
{"title":"Brucella suis in feral pigs in Australia: what is the risk?","authors":"CC Kneipp,&nbsp;D Marshall,&nbsp;ME Westman,&nbsp;R Malik,&nbsp;MA Stevenson,&nbsp;SM Mor,&nbsp;AK Wiethoelter","doi":"10.1111/avj.13441","DOIUrl":"10.1111/avj.13441","url":null,"abstract":"<p>In Australia, feral pigs (<i>Sus scrofa</i>) are the primary host for <i>Brucella suis</i>. The incidence of <i>B. suis</i> brucellosis in dogs in Queensland (QLD) and New South Wales (NSW) has increased, likely due to hunting and consumption of feral pig meat. This study aimed to update estimates of <i>B. suis</i> seroprevalence and spatial distribution in feral pigs and assess the risk of transmission to dogs. Serology results from 686 feral pigs in QLD and NSW were analysed, with seroprevalence correlated to pig population density. Serology results from 3074 dogs in QLD and NSW were mapped to local government areas (LGAs) and compared with pig density. Raw feral pig meat sold for pet consumption was tested for <i>B. suis</i>. Thirty-seven feral pigs were seropositive, with a survey adjusted true seroprevalence of 17% (95% confidence interval [CI] 12% to 22%) in QLD and 11% (95% CI 8% to 14%) in NSW. No positive spatial autocorrelation between positive and negative pigs was identified. Six hundred dogs from 26 QLD LGAs and 37 NSW LGAs were seropositive, showing a positive association with pig density. <i>Brucella suis</i> DNA was detected in commercially sold feral pig meat. This study found an increased prevalence and geographical expansion of infected pig populations potentially increasing the risk for <i>B. suis</i> transmission. The wide distribution and high level of detection in at-risk dogs highlight the links to pig hunting. Investigating human and dog cases could help identify infected pig populations, enabling hunters to reduce contact with infected pigs in those areas.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 7","pages":"379-387"},"PeriodicalIF":1.3,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of feline infectious peritonitis in cats with molnupiravir: clinical observations and outcomes for 54 cases 莫努匹拉韦治疗猫感染性腹膜炎54例临床观察及疗效观察。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-04-15 DOI: 10.1111/avj.13433
TM Clark, SJ Coggins, R Korman, J King, R Malik
{"title":"Treatment of feline infectious peritonitis in cats with molnupiravir: clinical observations and outcomes for 54 cases","authors":"TM Clark,&nbsp;SJ Coggins,&nbsp;R Korman,&nbsp;J King,&nbsp;R Malik","doi":"10.1111/avj.13433","DOIUrl":"10.1111/avj.13433","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the clinical applications and treatment outcomes using molnupiravir for the treatment of naturally occurring feline infectious peritonitis virus (FIPv).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ninety-two client-owned cats with confirmed or presumptive FIP were retrospectively recruited from 35 veterinary practices, primarily in Australia, between February 2023 and March 2024. Cats were categorised based on treatment received: Cohort A: Molnupiravir treatment: monotherapy, maintenance or rescue therapy; Cohort B: Remdesivir and/or GS-441524 treatment. Seventy-eight cats were enrolled. Molnupiravir was administered orally for a median of 84 days, at a median dose of 13.3 mg/kg BID. Remission was defined as the resolution of FIP-related signs with (i) normalisation of serum globulin concentrations and A:G ratio (≥0.6), or (ii) sustained clinical remission for at least 100 days after stopping anti-viral therapy. Cure rate was defined as the percentage of cats achieving sustained remission, without requiring rescue therapy or experiencing a relapsed disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Molnupiravir monotherapy resulted in a cure rate of 72% (13/18) while molnupiravir maintenance therapy achieved a cure rate of 86% (25/29), and molnupiravir utilised as a rescue therapy achieved a cure rate of 100% (7/7). Treatment with remdesivir/GS-441524 resulted in a cure rate of 71% (17/24 cats). Survival analysis revealed no difference in outcomes between cats treated with molnupiravir monotherapy and those treated with remdesivir/GS-441524. Adverse events associated with molnupiravir therapy included neutropenia, and transient elevations in hepatic enzymes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Molnupiravir demonstrated comparable survival outcomes to remdesivir/GS-441524 for treating FIP and serves as an accessible, effective option across various presentations, including ocular and neurologic forms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 6","pages":"339-353"},"PeriodicalIF":1.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of complications from perioperative urinary catheterisation in horses 马围手术期尿导尿并发症的发生率。
IF 1.3 4区 农林科学
Australian Veterinary Journal Pub Date : 2025-04-05 DOI: 10.1111/avj.13445
CT Quinn
{"title":"Incidence of complications from perioperative urinary catheterisation in horses","authors":"CT Quinn","doi":"10.1111/avj.13445","DOIUrl":"10.1111/avj.13445","url":null,"abstract":"<p>Catheterisation of the urinary bladder is a common procedure during perioperative care of horses. Benefits of urinary catheters include a reduction in the risk of recovery-associated slip hazards as a consequence of voided urine and the measurement of urine output during anaesthesia. However, there is little information regarding the risks associated with this procedure. A retrospective cohort study was undertaken in horses admitted to a university teaching hospital for surgery during which a urinary catheter was placed perioperatively. Data were retrieved from clinical records including signalment, procedure type, presence of pre-existing urinary/renal pathology, timing of catheter placement, complications from catheterisation, injuries during recovery and total volume of urine. Records were searched for evidence of urinary tract infections (UTI) or urethral strictures at any time following catheterisation. Descriptive statistics were calculated for numerical data. A total of 218 horses were included. The majority of catheters (<i>n</i> = 157, 70.7%) were placed immediately prior to recovery. The median volume of urine collected during anaesthesia was 4.89 mL/kg (0.0–37.66 mL/kg). The duration of catheterisation ranged from less than 20 min to 4 days. Complications occurred in three horses (1.4%) where the catheter could not be passed through the urethra, resulting in minor urethral trauma in one case. No clinical signs of UTI or urethral stricture were reported in any horse post-catheterisation. Short-term placement of urinary catheters during the perioperative period has a low incidence of complications. Difficulty inserting the catheter is occasionally encountered and may result in urethral injury.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 6","pages":"319-321"},"PeriodicalIF":1.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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