Australian Veterinary Journal最新文献

{"title":"Rectal mast cell tumour in a dog with lower grade features of biological aggressiveness","authors":"LYC Tay,&nbsp;L Brockley","doi":"10.1111/avj.13402","DOIUrl":"10.1111/avj.13402","url":null,"abstract":"<p>An 8-year-old, neutered female, Australian Silky Terrier presented to her primary veterinarian with non-specific clinical signs of general unwellness, shaking, lethargy, inappetence and no defecation for 2–3 days. A rectal mass was found on physical examination. The rectal mass was surgically resected and histopathology was consistent with a mast cell tumour (MCT) with a mitotic count of 0 per 2.37mm². The dog had follow-up chemotherapy protocol comprising of vinblastine and prednisolone and was doing well with no evidence of tumour recurrence 30 weeks post surgical resection and is still alive and clinically normal at the time of writing, 9 months post initial diagnosis. Primary MCTs of the gastrointestinal tract have previously been reported to be associated with a poor prognosis. This is the first report of a canine rectal mast cell tumour with lower grade features of biological aggressiveness and a possibly more favourable prognosis compared with the current published literature.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 3","pages":"116-120"},"PeriodicalIF":1.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series report: Equine coronavirus in Australia","authors":"S Horner,&nbsp;GF Agne,&nbsp;DP Byrne,&nbsp;ME Bain,&nbsp;BM Lynch,&nbsp;WR Gow,&nbsp;E-LJMM Verdegaal","doi":"10.1111/avj.13392","DOIUrl":"10.1111/avj.13392","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Equine Coronavirus (ECoV) can cause gastrointestinal disease and was first described in 2000 in the USA followed by several international outbreak case reports. Disease manifestation is characterised by vague clinical signs, including mild pyrexia, lethargy and anorexia. Morbidity ranges greatly from 10% to 83%. Although uncommon, ECoV may result in death secondary to disruption to the gastrointestinal barrier causing endotoxaemia and hyperammonaemic encephalopathy. Unfortunately to date, there is no vaccine available to prevent ECoV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case reports</h3>\u0000 \u0000 <p>Three faecal quantitative polymerase chain reaction (qPCR)-positive ECoV cases are described that presented with mild to severe colic signs: a 2-year-old Miniature Pony gelding from South Australia, an 8-year-old Arabian Riding Pony gelding, and a 6-year-old Warmblood mare, both from Western Australia. The diagnosis was based on a positive faecal qPCR, which is currently the gold standard diagnostic tool. All horses in this case series survived after medical management. The Miniature Pony presented with anorexia and mild colic signs. On day 5, the pony revealed severe colic signs unresponsive to analgesia along with severe abdominal distension secondary to caecal distension requiring surgical intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>To the authors' knowledge, this case series is the first published report of ECoV cases in Australia, and it adds both to the clinical description of the disease in horses and to the differential diagnosis list of colic signs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 1-2","pages":"56-62"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of clinical features, management and outcomes in dogs and cats with Eastern Brown Snake envenomation (2016–2022)","authors":"SK Day,&nbsp;KJ Nash,&nbsp;MJ Midwinter,&nbsp;WA Goodwin","doi":"10.1111/avj.13399","DOIUrl":"10.1111/avj.13399","url":null,"abstract":"<p>Australian Eastern brown snakes (<i>Pseudonaja textilis</i>) can cause venom-induced consumptive coagulopathy (VICC) in envenomated dogs and cats due to toxin-induced consumption of clotting factors. The objective of this study was to describe presenting clinical signs, prevalence of VICC and haemorrhage, VICC resolution timelines and patient outcomes in a population of dogs and cats with Eastern brown snake envenomation (EBSE). Data from dogs and cats presenting with EBSE were retrospectively evaluated. Univariable and multivariable analyses were performed to test predictor variable effects on outcomes. Animals who were euthanased for financial reasons on presentation were excluded from treatment and outcome analysis. Two-hundred and forty dogs and 98 cats were included. On presentation, 66% (159/240) of dogs had lower motor neuropathy (LMN), 31% (74/240) had preparalytic collapse and 30% (72/240) had signs of haemorrhage. In cats, 94% (92/98) had LMN, and only 5% (5/98) had haemorrhage. Ninety-two percent of dogs (209/226) and cats (81/88) were diagnosed with VICC on presentation and median time to normalisation of coagulation tests was 24 hours. Median hospitalisation length was 1.5 days for dogs (lower quartile [LQ]–upper quartile [UQ]: 1.0–3.0) and 2 days for cats (LQ – UQ: 1.0–2.5). Dogs presenting with LMN and no history of preparalytic collapse had significantly longer hospitalisation times (median 2.25 vs. 1.0 days, <i>P</i>-value &lt;0.001; median 2.0 vs. 1.0 days, <i>P</i>-value &lt;0.001 respectively). Odds of survival was lower in dogs with LMN (odds ratio [OR]: 0.23) and in the pooled multivariable analysis of dogs and cats with haemorrhage (OR: 0.39). The administration of antivenom overall was found to confer a survival advantage; however analysis failed to show increased odds of survival with administration of more than 4000 units. Overall, 89% (187/210) of dogs and 75% (58/77) of cats survived to discharge.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 3","pages":"77-87"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do Australian veterinarians perceive professional conduct in their profession?","authors":"Q Huang,&nbsp;I Van Gelderen","doi":"10.1111/avj.13400","DOIUrl":"10.1111/avj.13400","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Professional skills required for meeting standards of veterinary professional conduct demanded by the public, colleagues and the community are recognised as being equally important to the technical skills required of a veterinarian. To reflect current standards in the profession, this project describes how Australian veterinarians perceive aspects of veterinary professional conduct.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using an anonymous survey, opinions of Australian veterinarians were sought on perceptions of importance of professional conduct criteria derived from the eight standards listed in the Australian Veterinary Association's Code of Professional Conduct. Participants rated the importance of 15 statements on a six-point Likert scale. Univariable analysis of 98 completed responses was conducted where impacts of age, gender, career stage and the industry on the dependent variable (response to each statement) were evaluated using ordinary logistic regression analysis in R studio where odd ratios (ORs) were determined, and significance was at P &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The statement revealing the highest mean score with respect to perceived importance was ‘that veterinarians hold the health, welfare and respectful treatment of animals as a key concern’. Results indicated high levels of consensus with nine of 15 statements revealing no significant differences based on age, gender, career stage, and for all statements no significant difference based on nature of work. Six statements demonstrating significant differences were based on either gender, age or career stage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides insights into how Australian veterinarians perceive professional conduct. Results provide an aid for future study development and contribute to the discussion of veterinary professionalism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 1-2","pages":"66-72"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of screw placement order on range of proximal tibial fragment rotation adjustment and osteotomy gap formation when using manual reduction during tibial plateau levelling osteotomy (TPLO)","authors":"LYC Tay,&nbsp;SR Snelling","doi":"10.1111/avj.13396","DOIUrl":"10.1111/avj.13396","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the optimal first proximal screw position which permits proximal tibial fragment rotation adjustment while minimising osteotomy gap formation when a manual reduction technique is used for TPLO in dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>TPLOs were performed on bone models using Synthes 3.5-mm TPLO implants with a jig but without the use of an anti-rotational pin. The osteotomy was held in manual reduction with pointed reduction forceps placed across the proximal tibial fragment while the first three screws were applied. The first two screws were placed in the non-locking holes of the distal stem of the plate as per manufacturer's screw placement order guidelines. The third screw was placed in one of the three locking screw positions in the head of the plate, denoted as the ‘cranial’, ‘proximal’ and ‘caudal’ screw positions. After the first three screws were placed, the range of possible proximal tibial fragment rotation change (up to 6 mm in each direction) and the resultant cranial and caudal osteotomy gaps were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proximal screw position minimises cranial osteotomy gap formation with negative rotation changes to the proximal tibial fragment. The caudal screw position minimises caudal osteotomy gap formation with positive rotation changes to the proximal tibial fragment. Rotation change had a greater effect on cranial osteotomy gaps compared to caudal osteotomy gaps. The cranial screw position had the most limited osteotomy rotation change.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The proximal screw position should be placed first in the head of the plate to allow proximal tibial fragment rotation adjustment while minimising osteotomy gap formation when using a manual reduction technique when performing a TPLO.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 4","pages":"182-189"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptospiral infection in domestic mares in North Queensland","authors":"AL Alayil,&nbsp;PF Horwood,&nbsp;B Gummow,&nbsp;JA Picard,&nbsp;CJ Joone","doi":"10.1111/avj.13395","DOIUrl":"10.1111/avj.13395","url":null,"abstract":"<p><i>Leptospira</i> species are found worldwide, favouring tropical regions, and infect a wide range of animal species. Although renal persistence in infected individuals and excretion in urine is thought to be the primary mechanism of disease transmission, recent reports have suggested that persistence in the reproductive tract may be a feature in certain species, including the horse. The aim of this study was to investigate leptospiral infection, particularly within the reproductive tract, in healthy, non-breeding mares. Serum and endometrial swab samples were collected from 50 mares from the James Cook University Teaching Animal Herd, as well as, where possible, free-catch urine (<i>n</i> = 19). Sera were screened for antibodies to 24 <i>Leptospira</i> serovars, using the microscopic agglutination test (MAT). Endometrial and urine samples underwent real-time PCR testing, targeting the leptospiral <i>rrs</i> gene. Overall, the seroprevalence of leptospirosis was 48% (95% CI: 34%–62%), with serovars Arborea, Bratislava and Australis detected most frequently. PCR positive results were obtained from 1 of 50 (2%) endometrial swabs and 2 of 19 (11%) urine samples. This is the first report of serovar Bratislava in horses in Australia.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 1-2","pages":"63-65"},"PeriodicalIF":1.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of perioperative mortality in pet rabbits in Australia","authors":"EG Pieper,&nbsp;JE Carter,&nbsp;SM Firestone,&nbsp;HR Baron","doi":"10.1111/avj.13391","DOIUrl":"10.1111/avj.13391","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Domestic rabbits have higher perioperative mortality rates (1.39%–4.8%) compared with dogs and cats (0.1%–0.2%), with cardiovascular and respiratory complications reported most. Understanding anaesthetic risk factors is essential to minimise mortality risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine the perioperative mortality risks and risk factors in rabbits undergoing general anaesthesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study evaluated 1757 records of rabbits that underwent general anaesthesia with inhaled isoflurane, categorised by the American Society of Anesthesiologists (ASA) physical status classification system (January 2019–April 2023). Data were collected on physical characteristics, anaesthetic protocol, airway management and patient outcomes. Potential risk factors were analysed using multivariable logistic regression modelling guided by directed acyclic graphs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The perioperative mortality risk was 2.05% (95% CI: 1.39, 2.71). Increased mortality was most associated with poorer health status (ASA score) and non-routine procedures. Following induction of anaesthesia, rabbits with a body mass of less than 1 kg (RR: 7.57, 95% CI: 1.18, 61.2) and Netherland Dwarf rabbits (RR: 23.4, 95% CI: 2.75, 200) were at higher risk. The use of a supraglottic airway device was protective against mortality during anaesthesia compared with endotracheal tubes (RR: 0.27, 95% CI 0, 3.78) and anaesthetic masks (RR: 0.42, 95% CI: 0, 3.71). Increased mortality was observed with a fentanyl-based protocol compared with a medetomidine-based protocol (RR: 4.62, 95% CI: 0.477, 44.7).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Perioperative mortality was multifactorial, with health status, surgical complexity and physical characteristics representing primary risk factors. Clinicians should choose a suitable anaesthetic protocol, implement effective airway control and follow precautions for brachycephalic rabbit breeds.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 1-2","pages":"3-12"},"PeriodicalIF":1.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations into disease associations with feline immunodeficiency virus (FIV) infection in lions (Panthera leo) in Australia: a case–control study","authors":"A Dabydeen,&nbsp;KV Herrin,&nbsp;L Woolfenden,&nbsp;E Hall,&nbsp;ME Westman,&nbsp;JM Norris","doi":"10.1111/avj.13394","DOIUrl":"10.1111/avj.13394","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Feline immunodeficiency virus (FIV) is a highly mutable retrovirus with numerous species-specific strains, such as those infecting domestic cats (&lt;i&gt;Felis catus,&lt;/i&gt; FIV&lt;sub&gt;Fca&lt;/sub&gt;) and wild populations of nondomestic cats including lions (&lt;i&gt;Panthera leo&lt;/i&gt;, FIV&lt;sub&gt;Ple&lt;/sub&gt;). When FIV&lt;sub&gt;Fca&lt;/sub&gt; infection manifests as disease in domestic cats, common presentations include lymphadenopathy, lymphoid malignancies, oral cavity disease, immunological dysfunctions and neurological abnormalities. In contrast to domestic cats, there has been little published evidence of direct FIV&lt;sub&gt;Ple&lt;/sub&gt; disease associations in lions. The objective of the study, therefore, was to conduct a longitudinal case–control comparison of clinical findings and survival analysis of FIV&lt;sub&gt;Ple&lt;/sub&gt;-infected and FIV&lt;sub&gt;Ple&lt;/sub&gt;-uninfected captive lions to investigate possible FIV&lt;sub&gt;Ple&lt;/sub&gt; disease associations in nondomestic felids in Australia.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Between 2005 and 2023, 38 lions were recruited from zoos across Australia. Lions had been FIV tested as part of a routine diagnostic service. The 38 lions included in the study comprised 15 FIV-infected (9 males, 6 females) and 23 FIV-uninfected (9 males, 14 females) animals. Lifetime longitudinal clinical histories and clinicopathological data collected by zoos for these lions were interrogated, including survival data.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;FIV-infected lions were more likely to be reported with lower mean corpuscular volume (MCV) (fL) (P = 0.015), monocytes (%) (P = 0.023), chloride (mmol/L) (P = 0.016) and phosphate (mmol/L) (P = 0.029), but with a higher mean corpuscular hemoglobin concentration (MCHC) (g/L) (P = 0.001) and bicarbonate (mmol/L) (P = 0.035), than FIV-uninfected lions. The disease associations usually seen in domestic cats with FIV infection were not observed in lions, and there was no difference in survival between FIV-infected and FIV-uninfected lions. The main limitation of the study was a small sample size dictated by the number of lions able to be recruited from zoos in Australia over an 18-year period.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Few differences were found between case and control groups, suggesting that FIV-infected lions did not experience clinicopathological changes that predisposed them to future disease compared with FIV-uninfected lions. Further research will help to determine whether these results are indicative of a general absence of FIV-associated disease in captive lions, or the result of nonpathogenic FIV&lt;sub&gt;Ple&lt;/sub&gt; subtype(s) present in Austr","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 1-2","pages":"48-55"},"PeriodicalIF":1.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joseph O'BRIEN 1927–2022","authors":"P O'Brien,&nbsp;J Grieve,&nbsp;D Moen","doi":"10.1111/avj.13389","DOIUrl":"10.1111/avj.13389","url":null,"abstract":"","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"102 12","pages":"646-647"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcome of 73 dogs with iron EDTA molluscicide ingestion in Melbourne, Australia (2013–2019)","authors":"CA Lauinger,&nbsp;L Wright,&nbsp;L Smart","doi":"10.1111/avj.13388","DOIUrl":"10.1111/avj.13388","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The objective of this study was to describe the clinical features, treatments and outcomes of dogs with iron ethylenediaminetetraacetate (EDTA) molluscicide ingestion. We aimed to identify potential predictors of serum iron concentration &gt;54 μmol/L; a cut-off recommended for initiating treatment of human iron toxicosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Medical records across four veterinary hospitals (2013–2019) for dogs with known or suspected iron EDTA molluscicide ingestion were reviewed for signalment, clinical signs, clinicopathological data, treatment regimens and outcomes. Clinical signs of dogs with serum iron concentrations either below or above a cut-off of 54 μmol/L were compared using Fisher's exact test. Association between serum iron and urine discolouration was tested using logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy-three dogs were included. The most frequent characteristic was abnormal faeces (n = 47, 64%) as determined by rectal examination, with more dogs that had serum iron &gt;54 μmol/L showing this clinical sign (24/35), compared to dogs with serum iron &lt;54 μmol/L (4/13) (P = 0.025). Clinicopathologic abnormalities included increased base excess (n = 20/49, 20%), hyperglycaemia (n = 13/57, 23%) and hyperlactataemia (n = 12/57, 21%). Fifty-four dogs received deferoxamine chelation (74%), during which 25/42 (60%) dogs had discoloured urine despite all dogs having subsequent iron concentrations &lt;54 μmol/L. Admission serum iron concentration was associated with urine discolouration during hospitalisation (odds ratio 1.046, 95% confidence interval 1.008–1.107, P = 0.011). Sixty-nine dogs (95%) survived to discharge, with 10 dogs (14%) transferred to another veterinarian.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Iron EDTA molluscicide ingestion caused predominantly gastrointestinal clinical signs, and abnormal faeces, as well as urine discolouration during chelation therapy, which may indicate an elevation of serum iron concentration on presentation. Outcome was excellent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"103 1-2","pages":"13-21"},"PeriodicalIF":1.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}