Assay and drug development technologies最新文献

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Unlocking Antioxidant-Anticancer Synergy: An Exploration of Therapeutic Bioactives from Methanolic Extracts of Rubus ellipticus and Boerhavia diffusa Using HeLa Cell Line. 揭示抗氧化剂与抗癌剂的协同作用:利用 HeLa 细胞系探索椭圆茜草和白苧麻甲醇提取物中的治疗生物活性物质
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI: 10.1089/adt.2024.040
Vipresh Bhardwaj, G T Kulkarni, Kalpana Nagpal
{"title":"Unlocking Antioxidant-Anticancer Synergy: An Exploration of Therapeutic Bioactives from Methanolic Extracts of <i>Rubus ellipticus</i> and <i>Boerhavia diffusa</i> Using HeLa Cell Line.","authors":"Vipresh Bhardwaj, G T Kulkarni, Kalpana Nagpal","doi":"10.1089/adt.2024.040","DOIUrl":"10.1089/adt.2024.040","url":null,"abstract":"<p><p>\u0000 <i>This study aimed to assess the synergistic antioxidant and anticancer effects of methanolic extracts derived from <i>Rubus ellipticus</i> and <i>Boerhavia diffusa</i> fruits against the HeLa cell line. The methanolic extracts were prepared from the fruits of <i>R. ellipticus</i> and <i>B. diffusa</i>, and their antioxidant potential was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity assay and the ferric reducing antioxidant power (FRAP) assay. The anticancer effects of benzoic acid and rutin extracted from the aforementioned fruits were also investigated against the HeLa cell line using the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay to measure the cell metabolic activity. Using Synergy Finder plus software, the bioactive compounds were tested to explore any synergistic effects. <i>R. ellipticus</i> exhibited higher antioxidant potential as revealed by higher DPPH scavenging activity and FRAP value compared with <i>B. diffusa</i>. The benzoic acid extracted from <i>R. ellipticus</i> demonstrated potent anticancer activity against the HeLa cell line, with an IC<sub>50</sub> of 1.07 µg/mL. Similarly, rutin extracted from <i>B. diffusa</i> displayed moderate anticancer activity with an IC<sub>50</sub> of 1.4 µg/mL while exhibiting minimal impact on normal cell lines. The combination studies of the extracted bioactive compounds revealed a synergistic effect. These findings suggest the therapeutic potential of <i>R. ellipticus</i> and <i>B. diffusa</i> in combating the oxidative stress and cancer. Their bioactive compounds like benzoic acid and rutin were observed to act synergistically. Further investigations are warranted to elucidate the underlying mechanisms and evaluate their applicability in clinical settings.</i>\u0000 </p>","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"361-372"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug Repurposing Patent Applications: April-June 2024. 药物再利用专利申请:2024 年 4 月至 6 月。
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1089/adt.2024.081
Hermann A M Mucke
{"title":"Drug Repurposing Patent Applications: April-June 2024.","authors":"Hermann A M Mucke","doi":"10.1089/adt.2024.081","DOIUrl":"10.1089/adt.2024.081","url":null,"abstract":"","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"387-394"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyherbal Antiacne Gel: In Vitro Antibacterial Activity and Efficacy Evaluation Against Cutibacterium acnes. 多草本祛痘凝胶:针对痤疮杆菌的体外抗菌活性和功效评估
IF 1.8 4区 医学
Assay and drug development technologies Pub Date : 2024-09-10 DOI: 10.1089/adt.2024.031
Praveen Kumar Gaur,Rosaline Mishra,Rahul Kaushik,Krishan Kumar Verma,Nitin Kumar,Kank Lata
{"title":"Polyherbal Antiacne Gel: In Vitro Antibacterial Activity and Efficacy Evaluation Against Cutibacterium acnes.","authors":"Praveen Kumar Gaur,Rosaline Mishra,Rahul Kaushik,Krishan Kumar Verma,Nitin Kumar,Kank Lata","doi":"10.1089/adt.2024.031","DOIUrl":"https://doi.org/10.1089/adt.2024.031","url":null,"abstract":"Acne is a common skin condition that affects people of all ages and can lead to significant physical and psychological distress. The first line of action against acne is topical products, though the most effective are topical antibiotics. In such a scenario, the development of effective and safe herbal formulations for the treatment of acne is of great importance. Rubia cordifolia, Aloe barbadensis, and Allium cepa extracts are rich sources of bioactive metabolites and are safe compared with antibiotics, in addition to being cost effective, sustainable, and eco-friendly. Also, their combination has not been studied for treating acne, and their potential benefits need to be investigated. The present study aimed to develop an effective polyherbal gel formulation of R. cordifolia, A. barbadensis, and A. cepa combined extract for treating acne and validate its effect with reference to conventional antibiotics. Plant materials were extracted in water by the reflux method, and phytochemical analysis was done for flavonoid, anthraquinone, and phenolic contents. The combined extract (R. cordifolia, A. barbadensis, and A. cepa extracts) was formulated in gel. The selected polyherbal gel was evaluated for in vitro antibacterial activity using agar well diffusion against Cutibacterium acnes (P. acnes) culture. Phytochemical analysis of the composite extract revealed the rich presence of flavonoids, phenolics, and anthraquinones. The polyherbal gels showed good physicochemical properties; however, FCEG-4 was selected for further studies. It was found to be effective against C. acnes (MTCC 1951) in agar well diffusion, as it showed a similar zone of inhibition as that of standard. Also, during in vivo studies, FCEG-4 showed comparable efficacy with clindamycin gel. It was concluded from the study that composite extracts incorporated in an aqueous-based gel system were effective in topical therapy of mild acne vulgaris, showing similar efficacy to that of clindamycin cream.","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":"1 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142202113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latest Delivery Advancements of Lipid Nanoparticles for Cancer Treatment. 脂质纳米粒子用于癌症治疗的最新进展。
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-08-01 Epub Date: 2024-07-05 DOI: 10.1089/adt.2024.019
Somia Chauhan, Kalpana Nagpal
{"title":"Latest Delivery Advancements of Lipid Nanoparticles for Cancer Treatment.","authors":"Somia Chauhan, Kalpana Nagpal","doi":"10.1089/adt.2024.019","DOIUrl":"10.1089/adt.2024.019","url":null,"abstract":"<p><p>\u0000 <i>As one of the primary causes of illness and death globally, cancer demands novel and potent treatment approaches, which is why lipid nanoparticles (LNPs) have gained attention as a promising delivery system for anticancer drugs with precision and efficacy. The article discusses the salient characteristics of LNPs, such as the lipid components, particle size, polydispersity index, and encapsulation efficiency, followed by strategies that enhance their remarkable drug delivery capabilities. The articles explore LNPs ability to improve the solubility, stability, and bioavailability of various chemotherapeutics, nucleic acids, and immunotherapeutic modalities. It also highlights the recent advancement in surface modification of LNPs, which is essential to improve their effectiveness. Tailored coatings of LNPs improve targeting precision, stability, and biocompatibility; enhancing their transport to boost therapeutic efficacy for cancer targeting. The review summarizes the recent advancements made in using LNPs to treat different forms of cancer and focuses on the most recent clinical studies. Overall, the review highlights that the LNPs can target and treat cancer in a tailored manner through gene therapy, RNA interference, and immunotherapy.</i>\u0000 </p>","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"340-360"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel In Situ Gelling System of Quercetin/Sulfobutyl-Ether-β-Cyclodextrin Complex-Loaded Chitosan Nanoparticles for the Treatment of Vulvovaginitis. 用于治疗外阴阴道炎的槲皮素/磺丁基醚-β-环糊精复合物壳聚糖纳米粒子的新型原位胶凝系统
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-08-01 Epub Date: 2024-07-19 DOI: 10.1089/adt.2024.042
Amala Maxwell, Prachi Modi, Karishma Sequeira, Masuma Punja, Shaila Lewis
{"title":"A Novel <i>In Situ</i> Gelling System of Quercetin/Sulfobutyl-Ether-β-Cyclodextrin Complex-Loaded Chitosan Nanoparticles for the Treatment of Vulvovaginitis.","authors":"Amala Maxwell, Prachi Modi, Karishma Sequeira, Masuma Punja, Shaila Lewis","doi":"10.1089/adt.2024.042","DOIUrl":"10.1089/adt.2024.042","url":null,"abstract":"","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"308-324"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Antimicrobial Evaluation, and In Silico Studies of 2-Substituted-Phenyl-3-(5-Aryl/Heteroaryl Substituted Thiazol-2-yl) Thiazolidin-4-One Derivatives. 2-取代苯基-3-(5-芳基/杂芳基取代噻唑-2-基)噻唑烷-4-酮衍生物的合成、抗菌评估和硅学研究。
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1089/adt.2024.027
Swati Pawar, Ram Karan, Srija Hazarika, Mohan Lal, Ravindra K Rawal, Praveen Kumar Gupta
{"title":"Synthesis, Antimicrobial Evaluation, and <i>In Silico</i> Studies of 2-Substituted-Phenyl-3-(5-Aryl/Heteroaryl Substituted Thiazol-2-yl) Thiazolidin-4-One Derivatives.","authors":"Swati Pawar, Ram Karan, Srija Hazarika, Mohan Lal, Ravindra K Rawal, Praveen Kumar Gupta","doi":"10.1089/adt.2024.027","DOIUrl":"10.1089/adt.2024.027","url":null,"abstract":"","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"325-339"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Novel Acrylamide Graft Copolymer of Acacia nilotica Gum for the Stabilization of Melatonin Nanoparticles for Improved Therapeutic Effect: Optimization Using (3)2 Factorial Design. 合成新型刺槐胶丙烯酰胺接枝共聚物,用于稳定褪黑素纳米颗粒以提高治疗效果:使用 (3)2 因式设计进行优化。
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-08-01 Epub Date: 2024-07-04 DOI: 10.1089/adt.2024.013
Sonali Sundram, Neerupma Dhiman, Rishabha Malviya, Rajendra Awasthi
{"title":"Synthesis of Novel Acrylamide Graft Copolymer of <i>Acacia nilotica</i> Gum for the Stabilization of Melatonin Nanoparticles for Improved Therapeutic Effect: Optimization Using (3)<sup>2</sup> Factorial Design.","authors":"Sonali Sundram, Neerupma Dhiman, Rishabha Malviya, Rajendra Awasthi","doi":"10.1089/adt.2024.013","DOIUrl":"10.1089/adt.2024.013","url":null,"abstract":"<p><p>\u0000 <i>The objective of the present study was to optimize the microwave-assisted synthesis of the acrylamide graft copolymer of <i>Acacia nilotica</i> gum (AM-co-ANG). Furthermore, graft copolymer was used for the formulation of a nanoparticulate system using a novel top to bottom solvent antisolvent technique for the delivery of melatonin. Grafting of ANG was optimized by using 3<sup>2</sup> factorial design, where concentrations of polymer and monomer (acrylamide) were used as independent variables and swelling index in acidic (0.1 N HCl) and basic (1 N NaOH) pH. Grafted polymers were further used to develop and optimize nanoparticulate system using concentration of the graft copolymer and concentration of drug as independent variables. The size of the nanoformulation and entrapment efficiency were selected as dependent variables. Difference in infrared spectrum and absorbance maxima in the ultraviolet region confirm that grafting has taken place. Porous structure and a higher contact angle confirmed hydrophobic nature of AM-co-ANG as compared with the native polymer. Acrylamide graft copolymers show more swelling in 1 N NaOH as compared with 0.1 N HCl. <i>In vitro</i> toxicity studies in hepatic (HepG2 cell line), brain (SHSY5Y cell line), and skin (HaCaT cell line) cells easily predict that synthesized polymer have no cytotoxicity. The entrapment efficiency ranged from 55.24 ± 1.35% to 73.21 ± 1.83%. A nonlinear correlation was observed between independent and dependent variables, as confirmed by multivariate analysis of variance, surface regression, and the correlation report. The prepared formulations were able to release drug up to 12 h. The regression coefficient easily predicted that most of the formulations followed Baker-Lonsdale drug release kinetics.</i>\u0000 </p>","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"278-307"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-22-3p Inhibits 5-Fluorouracil Resistance in Cholangiocarcinoma Cells Through PTEN/PI3K/AKT Axis. MiR-22-3p 通过 PTEN/PI3K/AKT 轴抑制胆管癌细胞的 5-氟尿嘧啶抗性
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI: 10.1089/adt.2024.007
Ningrong Zhang, Li Zang
{"title":"MiR-22-3p Inhibits 5-Fluorouracil Resistance in Cholangiocarcinoma Cells Through PTEN/PI3K/AKT Axis.","authors":"Ningrong Zhang, Li Zang","doi":"10.1089/adt.2024.007","DOIUrl":"10.1089/adt.2024.007","url":null,"abstract":"<p><p>\u0000 <i>Cholangiocarcinoma (CCA) is a prevalent and highly lethal form of cancer globally. Although microRNAs (miRNAs) have been implicated in the advancement of CCA, their potential influence on 5-fluorouracil (5-Fu) resistance in CCA remains to be fully elucidated. Here, in this study, we investigated the impact of miR-22-3p on CCA resistance. Our investigation involved bioinformatics analysis, which revealed an association between miR-22-3p and the progression, diagnosis, and patient survival of CCA. Furthermore, we validated a notable downregulation of miR-22-3p expression in CCA cell lines. Elevated levels of miR-22-3p inhibit the activity and proliferation of 5-Fu-resistant CCA cell lines. In addition, we confirmed that phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a target gene of miR-22-3p, and its expression correlates with the survival of CCA patients. Reduced PTEN expression enhances apoptosis in 5-Fu-resistant CCA cells. Meanwhile, we verified the existence of the miR-22-3p/PTEN/phosphatidylinositol-3 kinase (PI3K)/Protein kinase B (AKT) regulatory networks in CCA, influencing the sensitivity of CCA cells to 5-Fu. In conclusion, our findings suggest that miR-22-3p acts as a tumor suppressor. Its overexpression inhibits the PTEN/PI3K/AKT axis, promoting cell apoptosis and enhancing CCA sensitivity to 5-Fu.</i>\u0000 </p>","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"217-228"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug Repurposing Patent Applications January-March 2024. 2024 年 1-3 月的药物再利用专利申请。
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-07-01 Epub Date: 2024-06-11 DOI: 10.1089/adt.2024.047
Hermann A M Mucke
{"title":"Drug Repurposing Patent Applications January-March 2024.","authors":"Hermann A M Mucke","doi":"10.1089/adt.2024.047","DOIUrl":"https://doi.org/10.1089/adt.2024.047","url":null,"abstract":"","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":"22 5","pages":"265-275"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Concise Review on Effect of PEGylation on the Properties of Lipid-Based Nanoparticles. PEG 化对脂基纳米粒子特性影响的简明综述。
IF 1.6 4区 医学
Assay and drug development technologies Pub Date : 2024-07-01 Epub Date: 2024-06-03 DOI: 10.1089/adt.2024.015
Janesha Krishnan, Praveena Poomalai, Ashwin Ravichandran, Aishwarya Reddy, Raman Sureshkumar
{"title":"A Concise Review on Effect of PEGylation on the Properties of Lipid-Based Nanoparticles.","authors":"Janesha Krishnan, Praveena Poomalai, Ashwin Ravichandran, Aishwarya Reddy, Raman Sureshkumar","doi":"10.1089/adt.2024.015","DOIUrl":"10.1089/adt.2024.015","url":null,"abstract":"<p><p>\u0000 <i>Nanoparticle-based drug delivery systems have emerged as promising platforms for enhancing therapeutic efficacy while minimizing off-target effects. Among various strategies employed to optimize these systems, polyethylene glycol (PEG) modification, known as PEGylation-the covalent attachment of PEG to nanoparticles, has gained considerable attention for its ability to impart stealth properties to nanoparticles while also extending circulation time and improving biocompatibility. PEGylation extends to different drug delivery systems, in specific, nanoparticles for targeting cancer cells, where the concentration of drug in the cancer cells is improved by virtue of PEGylation. The primary challenge linked to PEGylation lies in its confirmation. Numerous research findings provide comprehensive insights into selecting PEG for various PEGylation methods. In this review, we have endeavored to consolidate the outcomes concerning the choice of PEG and diverse PEGylation techniques.</i>\u0000 </p>","PeriodicalId":8586,"journal":{"name":"Assay and drug development technologies","volume":" ","pages":"246-264"},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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