Asian Pacific journal of allergy and immunology最新文献

{"title":"Pulmonary function characteristics in children with suspected asthma: implications for asthma diagnosis.","authors":"Mireu Park, Yun Young Roh, Ha Min Kim, Jae Hwa Jung, Soo Yeon Kim, Jong Deok Kim, Yong Ju Lee, Min Jung Kim, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn","doi":"10.12932/ap-020523-1601","DOIUrl":"https://doi.org/10.12932/ap-020523-1601","url":null,"abstract":"In children suspected of asthma, diagnosis is confirmed via variable expiratory airflow limitation. However, there is no single gold standard test for diagnosing asthma.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"76 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, predictors, and treatment outcomes of biphasic anaphylaxis in the emergency department of a tertiary hospital:A 5-year retrospective study.","authors":"Waratchaya Uawattanasakul, Ploylarp Lertvipapath, Thanachit Krikeerati, Chamard Wongsa, Torpong Thongngarm, Mongkhon Sompornrattanaphan","doi":"10.12932/ap-101223-1745","DOIUrl":"https://doi.org/10.12932/ap-101223-1745","url":null,"abstract":"Biphasic anaphylaxis despite successful treatment has an incidence of 4-5% based on NIAID/FAAN criteria. Our study aimed to investigate the frequency and predictive factors associated with biphasic reactions within the emergency department (ED) at Siriraj Hospital.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"16 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus exacerbation in ovalbumin-induced asthma in Fc gamma receptor IIb deficient mice, partly due to hyperfunction of dendritic cells.","authors":"Thansita Bhunyakarnjanarat, Jiradej Makjaroen, Wilasinee Saisorn, Kankorn Hirunsap, Jidapond Chiewchengchol, Patcharee Ritprajak, Asada Leelahavanichkul","doi":"10.12932/ap-290823-1677","DOIUrl":"https://doi.org/10.12932/ap-290823-1677","url":null,"abstract":"Although allergy might be another factor that exacerbates lupus as demonstrated by several epidemiologic studies, the direct correlation between lupus activities and allergy is still in question.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"22 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term impact of exposure to ambient air volatile organic compounds on daily clinic visits for urticaria in Kaohsiung, Taiwan.","authors":"Hui-Wen Tseng, Ling-Ying Lu","doi":"10.12932/ap-270923-1701","DOIUrl":"https://doi.org/10.12932/ap-270923-1701","url":null,"abstract":"Air volatile organic compounds (VOCs) cause allergic reaction mainly via the respiratory tract or skin.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"38 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCR combined with lateral flow dipstick assay (PCR-LFD) for a rapid diagnosis of melioidosis.","authors":"Priyapa Najomtien, Wisitsak Phoksawat, Sukanya Khammanthoon, Wadcharin Klasuk, Nuttiya Srisurat, Supaksorn Chattagul, Chotima Photisap, Chonlatip Pipattanaboon, Rasana W Sermswan, Surasakdi Wongratanacheewin","doi":"10.12932/ap-021023-1703","DOIUrl":"https://doi.org/10.12932/ap-021023-1703","url":null,"abstract":"Melioidosis is an infectious disease caused by Burkholderia pseudomallei. Septicemic melioidosis patients have a high mortality rate within 48 hours.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"22 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative anaphylaxis to chlorhexidine: Crucial role of in-vitro testing.","authors":"Alessandro Buonomo, Arianna Aruanno, Valter Perilli, Angela Rizzi, Manuela Ferraironi, Eleonora Nucera","doi":"10.12932/AP-250620-0890","DOIUrl":"10.12932/AP-250620-0890","url":null,"abstract":"<p><strong>Background: </strong>Chlorhexidine is a synthetic biguanide with a broad antibacterial activity and has become an important cause of perioperative anaphylaxis.</p><p><strong>Objective: </strong>Reactions due to chlorhexidine allergy are usually IgE-mediated. The aim of this report is to demonstrate utility of laboratory in-vitro testing for diagnosis.</p><p><strong>Methods: </strong>We report the case of a 36-year old man who experienced severe anaphylaxis during general anesthesia. He underwent skin tests, specific detection of specific IgE to chlorhexidine and basophil activation test (BAT).</p><p><strong>Results: </strong>Skin tests gave false positive results due to dermographism. So, on the basis of a clinical reaction to chlorhexidine and positive tests for IgE to chlorexidine and BAT, we assessed the diagnosis of chlorhexidine allergy.</p><p><strong>Conclusions: </strong>Physicians should be aware of the role of chlorhexidine in the etiology of perioperative anaphylaxis. In vitro testing such specific IgE and BAT are useful in patient with suspected chlorexidine allergy and limitation to perform skin tests.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"74-76"},"PeriodicalIF":5.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25411599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of food sensitization in young children with atopic dermatitis.","authors":"Araya Yuenyongviwat, Vanlaya Koosakulchai, Yada Treepaiboon, Wipa Jessadapakorn, Pasuree Sangsupawanich","doi":"10.12932/AP-250820-0946","DOIUrl":"10.12932/AP-250820-0946","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a common chronic and relapsing skin disease in children and food allergies have been well documented in one-third of children. However, there are limit data about the risk factors of food sensitization in children with AD.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the risk factors associated with food sensitization, among AD children.</p><p><strong>Methods: </strong>A cross-sectional study, from the electronic medical records of 119 AD patients, aged from 2 to 5 years were reviewed. The demographic data, onset and severity of AD, family history of atopy, age of first antibiotic usage, age of first applying and frequency of moisturizer used, age of introduction to allergenic foods and food specific IgE levels were recorded.</p><p><strong>Results: </strong>The prevalence of food sensitization was; 60%. The most common food allergens were egg white (56.8%), cow's milk (40%) and wheat (34.7%). The significant factors associated with overall food sensitization were; history of parent-reported food allergies (OR = 4.4, P = 0.001), severe AD (OR = 4.5, P = 0.03) and breast feeding > 6 months (OR = 3.5, P = 0.002). Factors associated with egg white allergies were the history of parent-reported food allergies (OR = 3.8, P = 0.02), and severe AD (OR = 4.2, P = 0.04). There were also significant factors associated with cow's milk allergies this being; severe AD (OR = 6, P = 0.03) and a maternal history of asthma (OR = 10.9, P = 0.01).</p><p><strong>Conclusions: </strong>Severe AD was a factor associated with all food sensitization, egg allergy and cow's milk allergy. Maternal asthma was also significantly associated with cow's milk allergy.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"30-35"},"PeriodicalIF":5.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38771357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilia, asthma, NERD and the use of oral corticosteroids predict uncontrolled chronic rhinosinusitis with nasal polyps after surgery.","authors":"Elina Penttilä, Saara Sillanpää, Seija I Vento, Jyri Myller, Anni Koskinen, Sari Hammarén-Malmi, Anu Laulajainen-Hongisto, Maija Hytönen, Annina Lyly, Markus Lilja, Paula Kauppi, Jura Numminen, Markus Rautiainen, Johanna Sahlman, Mikko Nuutinen, Sanna Toppila-Salmi, Paula Virkkula","doi":"10.12932/AP-310321-1102","DOIUrl":"10.12932/AP-310321-1102","url":null,"abstract":"<p><strong>Background: </strong>Severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) is a challenging condition to treat. The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS2020) has the following criteria when considering biological therapy for severe uncontrolled CRSwNP: eosinophilia, need for oral corticosteroids (OCS), symptom score, loss of sense of smell and co-morbid asthma.</p><p><strong>Objective: </strong>This study aimed at finding associations of baseline factors with uncontrolled CRSwNP after endoscopic sinus surgery (ESS).</p><p><strong>Methods: </strong>Electronic health record data of CRSwNP patients (N = 137) undergoing ESS in 2002-17 were used. Endpoints of uncontrolled CRSwNP were revision ESS, purchased OCS and antibiotic courses during follow up. Baseline factors were chosen based on EPOS2020 and the data available: nasal polyp (NP) eosinophilia, peripheral blood eosinophilia, co-existing asthma and/or non-steroidal anti-inflammatory drug exacerbated respiratory disease (NERD), need for OCS during the previous year, previous ESS, endoscopic NP score, and Lund-Mackay score of sinus computed tomography scans.</p><p><strong>Results: </strong>During the follow-up of 10.1 ± 3.1 (mean ± standard deviation) years, 35 (25.5%) individuals underwent revision ESS. The best predictive model was obtained by a sum of baseline (1) blood eosinophilia ≥ 250 cells/≥l and/or NP eosinophilia ≥ 30% (Eos), (2) asthma/NERD, and (3) ≥ 1 OCS/year. It was significantly associated with revision ESS, purchased doctor-prescribed OCS and antibiotic courses during follow-up.</p><p><strong>Conclusions: </strong>We identified similar predictive variables for uncontrolled CRSwNP that are used in the EPOS2020 indications of biological therapy, thus suggesting that these estimates are usable in clinical practice.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"50-60"},"PeriodicalIF":5.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39432383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The validity and reliability of the Thai version of the asthma control test.","authors":"Nutchanok Niyatiwatchanchai, Warawut Chaiwong, Chaicharn Pothirat","doi":"10.12932/AP-130820-0940","DOIUrl":"10.12932/AP-130820-0940","url":null,"abstract":"<p><strong>Background: </strong>The Asthma Control Test (ACT) has been widely used for the assessment of asthma control. However, it has never been validated in adult Thai asthmatic patients.</p><p><strong>Objective: </strong>To determine the validity and reliability of the Thai version of the ACT in adult Thai asthmatic patients.</p><p><strong>Methods: </strong>Any correlation between ACT and level of asthma controlled was determined using the Spearman's rank correlation coefficient. The ACT was carried out at 2 visits to a physician (4-12 weeks apart) to ascertain the level of reliability. Discriminant validity was determined using an area under receiver operating characteristic curve (AuROC) to identify the optimum cut-off point of the levels of control.</p><p><strong>Results: </strong>Seventy-one asthmatic adult patients, 40 (56.3%) female with a mean age of 54.2 ± 14.7 years were enrolled. The Thai version of ACT showed an acceptable internal consistency reliability with a Cronbach's alpha = 0.75. Test-retest reliability was 0.82. There was a significant correlation between the ACT scores and GINA symptom control tool (r = 0.87, p < 0.001). An ACT ≤ 22 was used to screen \"not well-controlled\" asthma with a sensitivity of 96.4% and specificity of 93.0% and an ACT score ≤ 19 was used to screen \"uncontrolled\" asthma.</p><p><strong>Conclusions: </strong>The Thai version of ACT is valid and a reliable tool for use in adult Thai asthmatic patients. However, the cut off points of ACT for levels of control should be changed to 22 and 19 for differentiation between well vs. partly controlled and partly vs. uncontrolled asthma, respectively.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"24-29"},"PeriodicalIF":5.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39119438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis.","authors":"Witchaya Srisuwatchari, Mongkhon Sompornrattanaphan, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Punchama Pacharn","doi":"10.12932/AP-250520-0856","DOIUrl":"10.12932/AP-250520-0856","url":null,"abstract":"<p><strong>Background: </strong>Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe and potentially life-threatening food allergy. Diagnosis of WDEIA is challenging because reactions are not always reproducible.</p><p><strong>Objective: </strong>This study aimed to evaluate the positivity rate of exercise-food challenge test at our allergy unit in order to confirm the diagnosis, and to investigate the effect on the episode of reactions after the test.</p><p><strong>Methods: </strong>This retrospective evaluation included patients aged 5-60 years who presented at the pediatric and adult allergy units of Siriraj Hospital during 2014-2018 with a convincing history of WDEIA and who underwent a 4-day exercise-food challenge test. Demographic data, challenge test result, and episodes of the reaction before and after the challenge test were obtained.</p><p><strong>Results: </strong>Fourteen of the 17 patients that were enrolled were included in the analysis. The 3 excluded patients were found to have IgE-mediated wheat allergy. Median age and time to diagnosis was 18.3 years (range: 10.5-43.4) and 1.8 years (range: 0.3-6.2). History of recurrent acute urticaria before the onset of anaphylaxis was reported in 5 patients (35.7%). Exercise-food challenge test was positive in 10 patients (71.4%). Median mean number of exacerbations per year before and after the confirmation test was 2 (range: 1-10) and 1 (range: 0-3), respectively.</p><p><strong>Conclusions: </strong>For WDEIA, time to diagnosis was delayed, and one-third of patients had recurrent acute urticaria proceeding anaphylaxis onset. Our exercise-food challenge test could be utilized safely in both children and adult and able to elicit symptoms in two-third of patients.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"43-49"},"PeriodicalIF":5.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38771356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}