A sero-epidemiological study after two waves of the COVID-19 epidemic.

IF 2.3 4区医学 Q3 ALLERGY

Asian Pacific journal of allergy and immunology Pub Date : 2024-09-01 DOI:10.12932/AP-040721-1177

Raheema Abdul-Raheem, Sheena Moosa, Fazeela Waheed, Maimoona Aboobakuru, Ibrahim N Ahmed, Fathmath N Rafeeg, Mariya Saeed

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引用次数: 0

Abstract

Background: The COVID-19 situation in Maldives have evolved since the epidemic began in March 2020 with unprecedented increase in cases since mid-July 2019 with over 8000 cases at the end of August 2020.

Objective: The aim of the sero-epidemiological investigation is to obtain a sense of the population exposure to the SARS-CoV-2 by measuring the seroprevalence of antibodies to COVID-19 in the general population.

Methods: A population-based, age-stratified prospective method was employed to find out the key epidemiological and serologic characteristics of COVID-19 virus in this study.

Results: The results showed that seroprevalence in the population was 13%. The factors that were associated with antibody results included age (OR: 4.0, CI: 1.7-9.0), nationality (OR: 12.9, CI: 8.3-19.7), being diagnosed for COVID-19 (OR: 24.7, CI: 15.9-38.4) and having symptoms of COVID-19 (OR: 2.0, CI: 1.5-2.8). There was a gradual decrease in the antibody levels from 19 days to 250 days. The mean duration of the presence of antibodies in this study was found to be 124 days.

Conclusions: While the seroprevalence provides a measure that can be used to predict community transmission risk of the disease, the extent of functional immunity provided by antibody titres is still not clear. It is acknowledged that other mechanisms of protection such as T cell mediated immunity will play an important role in providing individual protection.

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两波 COVID-19 流行后的血清流行病学研究。

背景：马尔代夫的COVID-19疫情自2020年3月开始流行以来不断发展，病例自2019年7月中旬以来空前增加，到2020年8月底已超过8000例：血清流行病学调查的目的是通过测量普通人群中 COVID-19 抗体的血清流行率，了解人群感染 SARS-CoV-2 的情况：方法：本研究采用基于人群、年龄分层的前瞻性方法，找出 COVID-19 病毒的主要流行病学和血清学特征：结果表明，人群中的血清流行率为 13%。与抗体结果相关的因素包括年龄（OR：4.0，CI：1.7-9.0）、国籍（OR：12.9，CI：8.3-19.7）、COVID-19 诊断（OR：24.7，CI：15.9-38.4）和 COVID-19 症状（OR：2.0，CI：1.5-2.8）。抗体水平从 19 天到 250 天逐渐下降。本研究发现，抗体存在的平均持续时间为 124 天：结论：虽然血清流行率提供了一个可用于预测疾病社区传播风险的指标，但抗体滴度所提供的功能性免疫的程度仍不明确。人们认识到，T 细胞介导的免疫等其他保护机制将在提供个体保护方面发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.