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Asian Journal of Organic & Medicinal Chemistry最新文献

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Screening of Anticancer Potential and DNA Damage Ability ofSyringodium isoetifolium against HeLa Cell Line 异叶丁香抗HeLa细胞潜能及DNA损伤能力的筛选
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p381
M. Pradeep, V. Shudarsan, M. Kaviraj, V. Lakshimi, D. Satheesh
{"title":"Screening of Anticancer Potential and DNA Damage Ability of\u0000Syringodium isoetifolium against HeLa Cell Line","authors":"M. Pradeep, V. Shudarsan, M. Kaviraj, V. Lakshimi, D. Satheesh","doi":"10.14233/ajomc.2022.ajomc-p381","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p381","url":null,"abstract":"Cervical cancer is a kind of cancer, which mainly occurs in the lower portion of uterus. Human papilloma virus plays a major role in the occurrence of cervical cancer. Major symptoms are vaginal bleeding, foul odour in vagina, pelvic pain, etc. It is mostly diagnosed by biopsy. Chemotherapy, radiation and surgery are the widely used treatments for cervical cancer, but the main drawback was their side effects. To avoid these conditions people might follow the ancient methods of treatment. Medicinal plants got wide attention in the current society to cure various diseases. The seagrass obtained from the seashores possess a wide range of medicinal properties like anticancer activity. In this study, the anticancer potentials of the seagrass, Syringodium isoetifolium was checked with the help of MTT and Comet assays. The various functional compounds present in the seagrass were also detected by FT-IR analysis. From the results obtained from MTT assay, the least inhibitory concentration of the sample was found to be 35.63 μg/mL. Further results obtained from the Comet assay prove that the sample has the ability to kill the cancer cells. This study concludes that the methanolic extract of Syringodium isoetifolium can be used as an alternative and marine based source for the treatment of cervical cancer.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86357259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring 3D QSAR Study of Pyridone-Pyrimidone Derivatives as GlucokinaseActivators in Treatment of Diabetes Mellitus by using CoMFA Method CoMFA法探讨吡啶酮-嘧啶酮衍生物作为葡萄糖激酶激活剂治疗糖尿病的三维QSAR研究
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p360
Priyanka N. Chhajed, R. B. Patil
{"title":"Exploring 3D QSAR Study of Pyridone-Pyrimidone Derivatives as Glucokinase\u0000Activators in Treatment of Diabetes Mellitus by using CoMFA Method","authors":"Priyanka N. Chhajed, R. B. Patil","doi":"10.14233/ajomc.2022.ajomc-p360","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p360","url":null,"abstract":"In this work, we have performed 3D QSAR study of reported pyridone-pyrimidone derivatives. CoMFA was applied to generate 3D QSAR models. Total eight QSAR models were generated. Model 2 was close to standard set criteria. Effect of steric and electrostatic substituents on biological activity was observed on contour maps. This study will be helpful for future researchers in designing new pyridinepyrimidone derivatives.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91424291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound Assisted New Imines of 3E-3-(4-Substituted benzylidene)-4-(substituted-1,3,4-thiadiazole-2-ylimino)pentane-2-one and their Antimicrobial Studies 超声辅助3E-3-(4-取代苄基)-4-(取代-1,3,4-噻二唑-2-酰基)戊烷-2- 1的新亚胺及其抗菌研究
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p364
M.B. Zade, S. N. Ibatte
{"title":"Ultrasound Assisted New Imines of 3E-3-(4-Substituted benzylidene)-4-(substituted-1,3,4-\u0000thiadiazole-2-ylimino)pentane-2-one and their Antimicrobial Studies","authors":"M.B. Zade, S. N. Ibatte","doi":"10.14233/ajomc.2022.ajomc-p364","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p364","url":null,"abstract":"A new series of Schiff bases of 3-(4-substituted benzylidene)-4-(substituted-1,3,4-thiadiazole-2- ylimino)pentane-2-one having various substituents of aryl attached to acetoacetone by Knovengel condensation and substituted 1,3,4-thiadiazole were synthesized by using solid supported tetrabutylammonium hydrogen sulfate in microwave irradiation. The synthesized Schiff bases have been evaluated by 1H NMR, elemental analysis, FTIR, mass spectroscopy. All Schiff bases have been screened for their antimicrobial activities. These compounds possess good result of antimicrobial studies.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88069753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review Paper on Net Zero Energy Buildings 净零能耗建筑检讨文件
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp48-50
{"title":"Review Paper on Net Zero Energy Buildings","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp48-50","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp48-50","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74815898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Stabilization Using Fly Ash of Clayey Soil – A Review 粉煤灰在粘性土中的稳定研究进展
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp83-85
{"title":"Stabilization Using Fly Ash of Clayey Soil – A Review","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp83-85","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp83-85","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82221451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Investigation of Fluoro, Iodo and Hydroxy Derivative ofChloro Substituted Homoisoflavonoids 氯代同型异黄酮的氟、碘和羟基衍生物的药理研究
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p357
D. Gaikwad, R. Murkute, S. Gaikwad
{"title":"Pharmacological Investigation of Fluoro, Iodo and Hydroxy Derivative of\u0000Chloro Substituted Homoisoflavonoids","authors":"D. Gaikwad, R. Murkute, S. Gaikwad","doi":"10.14233/ajomc.2022.ajomc-p357","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p357","url":null,"abstract":"In present study, the synthesized substituted homoisoflavonoid derivatives were screened for their in vivo/in vitro antiarthritic activity, in vitro anti-inflammatory and DPPH free radical scavenging activity. The male Wistar rats were used for investigation of in vivo antiarthritic activity against complete freund’s adjuvant (CFA) induced arthritis and assessment was done for change in paw volume, serum marker enzymes (ALP, SGOT and SGPT) and membrane stabilization potential. in vitro anti-inflammatory activity was assessed by the protein denaturation method. In vitro free radical scavenging activity was assessed by the DPPH method. The result indicated that compound HIFa showed a significant antiarthritic activity as compared to other substituted homoisoflavonoid derivatives. The significant membrane stabilization and inhibition of protein denaturation showed in vitro antiarthritic and antiinflammatory activity of substituted homoisoflavonoid derivatives. The substituted homoisoflavonoid derivatives showed dose dependent DPPH free radical scavenging activity. From the present study, it was observed that the iodo derivative of substituted homoisoflavonoid derivatives have significant pharmacological activities as compared to floro and hydroxyl derivatives.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90923695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on the Strength Aspects of Light Weight Concrete Using Ultra-light Weight Foamed Glass Aggregate 超轻泡沫玻璃骨料轻混凝土强度研究进展
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp17-19
{"title":"A Review on the Strength Aspects of Light Weight Concrete Using Ultra-light Weight Foamed Glass Aggregate","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp17-19","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp17-19","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76198181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave Assisted a Highly Atom Economic, Chemo-, Regio- andStereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine-2′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents 微波辅助下高原子经济性、化学选择性、区域选择性和立体选择性合成[1h -茚-2,3 ' -吡咯烷-2 '，3 " -[3H]吲哚]-1,2 " (1 " H)二酮类抗菌和抗真菌药物的评价
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p356
M. Kaleeswari, P. S. Harikrishnan
{"title":"Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and\u0000Stereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine-\u00002′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents","authors":"M. Kaleeswari, P. S. Harikrishnan","doi":"10.14233/ajomc.2022.ajomc-p356","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p356","url":null,"abstract":"1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79197923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Characterization, Antimalarial and Anticancer Activities ofFew New Amino Analogues of 1,4-Naphthoquinone 1,4-萘醌氨基类似物的合成、表征及抗疟抗癌活性研究
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p372
S. Sanjay, Shashiprabha, K. Shridhara, K. Nagarajan, H. Sivaramakrishnan, B. Arun
{"title":"Synthesis, Characterization, Antimalarial and Anticancer Activities of\u0000Few New Amino Analogues of 1,4-Naphthoquinone","authors":"S. Sanjay, Shashiprabha, K. Shridhara, K. Nagarajan, H. Sivaramakrishnan, B. Arun","doi":"10.14233/ajomc.2022.ajomc-p372","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p372","url":null,"abstract":"Present study involves the synthesis, characterization, antimalarial and anticancer activities of some novel substituted amino analogues of 1,4-naphthoquinone. The chloro group present in the key starting materials like 2,3-dichloro-1,4-naphthoquinone (1) and 2-chloro-3-[trans-4-(4-chlorophenyl)- cyclohexyl]-1,4-naphthoquinone (2) was replaced by substituted amines. These analogues were isolated, purified and screened for antimalarial and anticancer activities. A few of the novel compounds were found to possess substantial biological activity and are reasonably potent.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85211679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Study the Effect of Unbalancing on Two Overhung Rotors by Vibration Monitoring 通过振动监测研究不平衡对双悬挑转子的影响
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp235-238
{"title":"To Study the Effect of Unbalancing on Two Overhung Rotors by Vibration Monitoring","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp235-238","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp235-238","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87134500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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