Ultrasound Assisted New Imines of 3E-3-(4-Substituted benzylidene)-4-(substituted-1,3,4- thiadiazole-2-ylimino)pentane-2-one and their Antimicrobial Studies

Abstract

A new series of Schiff bases of 3-(4-substituted benzylidene)-4-(substituted-1,3,4-thiadiazole-2- ylimino)pentane-2-one having various substituents of aryl attached to acetoacetone by Knovengel condensation and substituted 1,3,4-thiadiazole were synthesized by using solid supported tetrabutylammonium hydrogen sulfate in microwave irradiation. The synthesized Schiff bases have been evaluated by 1H NMR, elemental analysis, FTIR, mass spectroscopy. All Schiff bases have been screened for their antimicrobial activities. These compounds possess good result of antimicrobial studies.