Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and Stereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine- 2′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents

Abstract

1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.