微波辅助下高原子经济性、化学选择性、区域选择性和立体选择性合成[1h -茚-2,3 ' -吡咯烷-2 '，3 " -[3H]吲哚]-1,2 " (1 " H)二酮类抗菌和抗真菌药物的评价

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI:10.14233/ajomc.2022.ajomc-p356

M. Kaleeswari, P. S. Harikrishnan

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引用次数: 0

摘要

以高度立体和区域选择性的方式，用2-(芳基亚甲基)-2,3-二氢- 1h -吲哚-1- Œ- Œ-[3H]吲哚]-1,2 - Œ- Œ(1′Œ′ŒH)二酮，对肌氨酸和取代的isatins进行脱羧缩合，原位生成非稳定的偶极环加成，得到了dispiro[1h -吲哚-2,3′Œ-pyrrolidine-2′Œ，3′Œ′Œ] 1,2′Œ′Œ(1′Œ′ŒH)二酮。合成的化合物进行了抗菌和抗真菌研究。发现许多化合物对所有被试生物都具有相当的抗菌和抗真菌活性。

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Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and Stereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine- 2′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents

1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.

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Asian Journal of Organic & Medicinal Chemistry

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