{"title":"微波辅助下高原子经济性、化学选择性、区域选择性和立体选择性合成[1h -茚-2,3 ' -吡咯烷-2 ',3 \" -[3H]吲哚]-1,2 \" (1 \" H)二酮类抗菌和抗真菌药物的评价","authors":"M. Kaleeswari, P. S. Harikrishnan","doi":"10.14233/ajomc.2022.ajomc-p356","DOIUrl":null,"url":null,"abstract":"1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and\\nStereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine-\\n2′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents\",\"authors\":\"M. Kaleeswari, P. S. Harikrishnan\",\"doi\":\"10.14233/ajomc.2022.ajomc-p356\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.\",\"PeriodicalId\":8544,\"journal\":{\"name\":\"Asian Journal of Organic & Medicinal Chemistry\",\"volume\":\"3 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Organic & Medicinal Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14233/ajomc.2022.ajomc-p356\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic & Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14233/ajomc.2022.ajomc-p356","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and
Stereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine-
2′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents
1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3Œ-pyrrolidine-2Œ,3ŒŒ-[3H]indole]-1,2ŒŒ(1ŒŒH)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.