{"title":"CoMFA法探讨吡啶酮-嘧啶酮衍生物作为葡萄糖激酶激活剂治疗糖尿病的三维QSAR研究","authors":"Priyanka N. Chhajed, R. B. Patil","doi":"10.14233/ajomc.2022.ajomc-p360","DOIUrl":null,"url":null,"abstract":"In this work, we have performed 3D QSAR study of reported pyridone-pyrimidone derivatives. CoMFA was applied to generate 3D QSAR models. Total eight QSAR models were generated. Model 2 was close to standard set criteria. Effect of steric and electrostatic substituents on biological activity was observed on contour maps. This study will be helpful for future researchers in designing new pyridinepyrimidone derivatives.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"73 9","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring 3D QSAR Study of Pyridone-Pyrimidone Derivatives as Glucokinase\\nActivators in Treatment of Diabetes Mellitus by using CoMFA Method\",\"authors\":\"Priyanka N. Chhajed, R. B. Patil\",\"doi\":\"10.14233/ajomc.2022.ajomc-p360\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this work, we have performed 3D QSAR study of reported pyridone-pyrimidone derivatives. CoMFA was applied to generate 3D QSAR models. Total eight QSAR models were generated. Model 2 was close to standard set criteria. Effect of steric and electrostatic substituents on biological activity was observed on contour maps. This study will be helpful for future researchers in designing new pyridinepyrimidone derivatives.\",\"PeriodicalId\":8544,\"journal\":{\"name\":\"Asian Journal of Organic & Medicinal Chemistry\",\"volume\":\"73 9\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Organic & Medicinal Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14233/ajomc.2022.ajomc-p360\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic & Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14233/ajomc.2022.ajomc-p360","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Exploring 3D QSAR Study of Pyridone-Pyrimidone Derivatives as Glucokinase
Activators in Treatment of Diabetes Mellitus by using CoMFA Method
In this work, we have performed 3D QSAR study of reported pyridone-pyrimidone derivatives. CoMFA was applied to generate 3D QSAR models. Total eight QSAR models were generated. Model 2 was close to standard set criteria. Effect of steric and electrostatic substituents on biological activity was observed on contour maps. This study will be helpful for future researchers in designing new pyridinepyrimidone derivatives.