Asian Journal of Pharmaceutical Research最新文献_第6页

Particle Engineering for Customized Drug Particles and its Applications 定制药物颗粒的颗粒工程及其应用

Asian Journal of Pharmaceutical Research Pub Date : 2022-11-22 DOI: 10.52711/2231-5691.2022.00055

Niraj Kale, Ketaki Shinde, Sonam Bendre, Suhit S. Gilda

引用次数: 0

In-silico Study of Phytoconstituents from Tribulus terrestris as potential Anti-psoriatic agent 刺蒺藜植物成分抗银屑病潜在药物的计算机模拟研究

Asian Journal of Pharmaceutical Research Pub Date : 2022-11-22 DOI: 10.52711/2231-5691.2022.00043

R. Gaikwad, Sanket Rathod, Anilkumar Shinde

{"title":"In-silico Study of Phytoconstituents from Tribulus terrestris as potential Anti-psoriatic agent","authors":"R. Gaikwad, Sanket Rathod, Anilkumar Shinde","doi":"10.52711/2231-5691.2022.00043","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00043","url":null,"abstract":"Introduction: Psoriasis (Ps) is a well-known chronic non-infectious, inflammatory skin disease affecting about 2–3% of the worldwide Population. Pathogenesis includes the environmental trigger factors with other factors like genetic factors, trauma, chemicals, bacterial infection etc. Currently there is no drug which can permanently cure the skin lesions as well as completely eradicate this dermatosis. The purpose of this research is to investigate the anti-psoriatic activity of phytoconstituents of Tribulus terrestris by predicting the ligand-receptor binding and by predicting the ADMET parameters using Lipinski's rule. Methodology: The process of research work starts with protein and ligand structure preparation. Further docking was done using PyRxAutodock Vina. Afterward, analysis and visualisation of the interaction between protein-ligands was done, and ADMET profiling was carried out according to lipinski's rules using Swiss ADME. Result: we selected four phytoconstituents of Tribulus terrestris. Molecular docking simulation showed all four compounds had better binding affinities. Based on the results of prediction of ADMET values using the Lipinski rule, compound that are thought to have good activity. Conclusion: Based on results these molecules have discovered that they may be able to produce anti-psoriatic activity and found that they have a lower toxicity, and ADME analysis determined the easily absorbability to the tissue site. Hence, these compounds can be analysed by further in vitro studies and can be a leader in the designing of the potential drug for the psoriasis management.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91532177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antifungal Activity of Senna alata – A Review 番泻草抗真菌活性研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2022-11-22 DOI: 10.52711/2231-5691.2022.00050

Muhammad Hamza Ashfaq, M. Yousaf

引用次数: 1

A Comprehensive Review on Targeted Drug Delivery System 靶向给药系统研究综述

Asian Journal of Pharmaceutical Research Pub Date : 2022-11-22 DOI: 10.52711/2231-5691.2022.00053

Wajid Ahmad, T. Khan, I. Basit, Javed Imran

引用次数: 0

Design, in-silico ADME Study and molecular docking study of novel quinoline-4-on derivatives as Factor Xa Inhibitor as Potential anti-coagulating agents 新型喹啉-4-on衍生物作为Xa因子抑制剂潜在抗凝剂的设计、硅ADME研究和分子对接研究

Asian Journal of Pharmaceutical Research Pub Date : 2022-08-12 DOI: 10.52711/2231-5691.2022.00034

Nikunj Patadiya, V. Vaghela

{"title":"Design, in-silico ADME Study and molecular docking study of novel quinoline-4-on derivatives as Factor Xa Inhibitor as Potential anti-coagulating agents","authors":"Nikunj Patadiya, V. Vaghela","doi":"10.52711/2231-5691.2022.00034","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00034","url":null,"abstract":"The main aim of present work is to identification of potency of novel quinoline-4-one derivatives as a factor Xa inhibitors by in-silico ADME study and molecular docking study. Factor Xa is enzyme which play major role in blood coagulation process by conversation of prothrombine to thrombine. Thrombine is the protein which converts fibrinogen to fibrin (clot). Inhbition of factor Xa is altimetly inhbition of blood coagulation process. Due to the abnormal blood coagulation, serious to very serious problems can create and will lead to death. Betrixaban, Rivaroxaban, Epixaban and Edoxaban which are FDA approval dugs as factor Xa inhibitors. They are very potent drugs and very few side effects compare to other available anti-coagulating drugs so they was taken as a reference molecules for current study. Some novel quinoline-4-one derivatives was design and screened for factor Xa enzyme. We design 26 compounds and first they screen for in-silico ADME parameters. Very few compounds not pass Lipinski rule. A majority compound shows excellent in-silico ADME properties. In molecular docking study almost all compound shows near binding energy to reference drug and shows almost near dock score. Q23 and Q26 show excellent inhibitory activity against Factor Xa. 13 molecules shows very near dock score compare to reference drugs. This study became a reference and provides valuable data for the synthesis, in-vitro and in-vivo evaluation of quinolone-4-on derivatives as Factor Xa inhibitors.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88211556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microwave Generated Bionanocomposites for Solubility and Dissolution Enhancement of Poorly Water Soluble Drug 微波制备生物纳米复合材料增强难水溶性药物的溶解度和溶出度

Asian Journal of Pharmaceutical Research Pub Date : 2022-08-12 DOI: 10.52711/2231-5691.2022.00031

Suxam Suxam, Nitan Bharti, Pooja Sharma, N. Kumari

引用次数: 0

Synthesis, Characterization, Antibacterial and Antifungal study of Novel Co (II) metal complexes of bidentate 3-Formylchromone based Schiff bases 新型希夫碱双齿3-甲酰基色素Co (II)金属配合物的合成、表征及抑菌抑菌研究

Asian Journal of Pharmaceutical Research Pub Date : 2022-08-12 DOI: 10.52711/2231-5691.2022.00033

Ram Vishun Prasad, Ashutosh Singh

引用次数: 0

A Study on Formulation and Evaluation of Herbal Hand Sanitizer and Herbal Handwash 草药洗手液和草药洗手液配方及评价研究

Asian Journal of Pharmaceutical Research Pub Date : 2022-08-12 DOI: 10.52711/2231-5691.2022.00032

Priyanka Kusarkar, Mayuri Kupkar, Trupti D Dudhgaonkar

引用次数: 3

A Review on: Therapeutic Activities of Spirulinaon skin 螺旋藻对皮肤的治疗作用研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2022-08-12 DOI: 10.52711/2231-5691.2022.00039

Tejshri Tambe, Mayur Bhosale, Pankaj Sonawane, S. Shinde

{"title":"A Review on: Therapeutic Activities of Spirulinaon skin","authors":"Tejshri Tambe, Mayur Bhosale, Pankaj Sonawane, S. Shinde","doi":"10.52711/2231-5691.2022.00039","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00039","url":null,"abstract":"Spirulina stands out as a sustainable bioactive microalga with health promoting parcels, and an important active element of natural cosmetics products. Presently, Spirulina has been incorporated in topical skin care phrasings, similar as a moisturizing, antiwrinkles, antiaging and antiacne agent. Likewise, this microalga is used by ornamental inventors to promote healthy sunscreen protection, to treat skin achromatism conditions and to heal injuries. Utmost of marketablecosmetics claim an outsized range of Spirulina parcels, including antioxidant, revitalizing, remineralizing, moisturizing, guarding alongside sanctification and shining action, both for hair and for skin. In this review, recent ornamental operations of Spirulina are revised, by pressing its capability in perfecting skin appearance and health. Also, the analysis of the Spirulina ornamental standardis mooted. Looking at the current emergence of the beauty assiduity, numerous Spirulina extracts anddry cream/ flakes, both the starting element and final Spirulina rested ornamental products, areavailable on the request. In this artificial field, Spirulina — substantially Spirulina platensis and Spirulinamaxes — is used either as a cream, like in the case of cheaper products, or as a phycocyaninrichblue Extract, particularly in the luxury request.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88760533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AQBD Approach in Chemo metric assisted Method Development for the Estimation of Ciprofloxacin and Metronidazole by UV-VIS Spectrophotometry 紫外-可见分光光度法测定环丙沙星和甲硝唑的AQBD方法

Asian Journal of Pharmaceutical Research Pub Date : 2022-08-12 DOI: 10.52711/2231-5691.2022.00030

S. Jogdand, K. Mane, Rohit B Jadhav, G. Dyade

{"title":"AQBD Approach in Chemo metric assisted Method Development for the Estimation of Ciprofloxacin and Metronidazole by UV-VIS Spectrophotometry","authors":"S. Jogdand, K. Mane, Rohit B Jadhav, G. Dyade","doi":"10.52711/2231-5691.2022.00030","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00030","url":null,"abstract":"Quality by design is applied for the development of various pharmaceutical processes including analytical methods. By applying QbD approach chemometric based analytical method was developed for the estimation of Ciprofloxacin (CFN) and Metronidazole (MND) by UV-VIS spectrophotometry. Solvent Distilled water was utilised and 271.5nm and 319nm were the wavelength of absorbance measurement for CFN and MND respectively. Effect of input variables on spectrum characteristics were studied for selection of critical parameters and developed method was validated as per ICH Q 2 R1 regulatory guidelines. Linearity of both the drugs was ascertained over the conc range 1 -14mcg/ml. The accuracy of assay was found 98% for CFN and 100.78% for MND; and the precision study was shown acceptable data as %RSD data varied from 0.6369 to 1.3192 for CFN and from 0.5509 to 1.2171 for MND. The developed method is rigid, robust and efficient for the estimation of CFN and MND from the composition of dosage form. QbD was applied to build rigid robust method through risk assessment at early stage and defining the design space at the later stage.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91275879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2