Asian Journal of Pharmaceutical Research最新文献

{"title":"Formulation and Evaluation of Yohimbine HCl Proliposomal Gels","authors":"Wajid Ahmad, Rihan Jawed","doi":"10.52711/2231-5691.2022.00049","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00049","url":null,"abstract":"The study was aimed to develop a proliposomal formulation for anti- inflammatory drug Yohimbine HCl. Proliposomes with various concentrations of mannitol, phospholipid and cholesterol were prepared using thin-film hydration technique (vacuum rotatory evaporator). The optimization of proliposomal formulation was achieved based on Average size, Entrapment efficiency and drug content. The proliposomal formulation was incorporated in the gel (carbopol) and characterized for their rheology and in vitro drug release studies. The results of formulations revealed that maximum entrapment efficiency was dependent on phospholipid and cholesterol concentration. Rheological studies revealed that the proliposome formulation containing 2% w/w carbopol is stable for topical drug delivery. The In-vitro studies revealed that proliposomal gel formulation exhibits increased skin permeation showing sustain release when compared to that of pure drug.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80971627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro Screening of Anti-microbial, Anti-fungal and Anti-oxidant activities of Ethanolic leaf extract of Anthocephalus cadamba","authors":"Priyanka Nalla, S. M, G. Babu, S. M., V. Sri, Vasanthi M., Lakshmi Bhargavi K. Sri, T. Y., Vasavi K. Mohana Sri, Raviteja N.","doi":"10.52711/2231-5691.2022.00044","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00044","url":null,"abstract":"Anthocephalus cadamba, Rubiaceae, is a medicinal herb of great importance for traditional applications against several disease kinds. Because of the range of compounds, the genus Anthocephalus is regarded as one of the most significant genus utilised in many medical systems. The plant was chemically investigated for its phytoconstituents in the current analysis, Anthocephalus cadamba. The results for steroids, flavanoids, tannins and glycosides were shown to be positive. Bacterial species, such as Staphylococcus aureus, Bacillus subtiliis and Escherichia coli, have been moderately actively monopolised. Antifungal activity at doses of 100mg/ml, 300mg/ml with fungal organisms, was observed in the ethanol leaves extract. Plant ethanol extract had a substantial impact on the hydrogen peroxide radical activity of scavenging and less effects than the standard of nitric oxide radical activity.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83311170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Arthritis, A Laconic Review to understand their Basic Concept and Management Process","authors":"S. Sweta, A. Chaudhary, V. Pandit, M. Ashawat, Tarun Kumar","doi":"10.52711/2231-5691.2022.00051","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00051","url":null,"abstract":"Rheumatoid arthritis is a chronic inflammatory illness characterized by joint stiffness, bone and cartilage destruction, and swelling above the joints. The condition is linked to chemicals found within the major histocompatibility complex, also as T-cells that are hooked in to them. The condition is more severe in women than in men, also as within the elderly population. The effects of gender on the clinical course of the disease are studied, but the results are mixed. The factor like genetic, environmental, smoking, and age of a person were trigger’s the rheumatoid arthritis. The other clinical complications were observed in patients with rheumatoid arthritis which includes depression, infection, malignancy, cardiovascular disorder, pulmonary disease etc. According to research, RA risk might be impacted by a genetic predisposition, environmental factors, or a combination of both. Immune cells such as lymphocytes, neutrophils, and macrophages have long been thought to have a role in the development of RA involved in pathological mechanism. Rheumatoid arthritis have been diagnosed by imaging with colour doppler sonography or gadolinium-enhanced magnetic resonance imaging can detect the presence of osynovitis, and serologic testing for auto-antibodies and APRs was required to diagnose rheumatoid arthritis. To cure and prevent the patients form rheumatoid arthritis it is very necessary to take suitable treatment. So, in present work we also highlighted the available drugs used for the treatment of RA. The first line therapy agents include Non-steroidalantiinflammatory drugs, and corticosteroids. The second line agents used in RA are Disease modifying Antirheumatic drugs (DMARDs). The patients having age more than 60 years also need surgery to cure rheumatoid arthritis. To decrease the side effects from some potent agents include methotrexate the vitamin D, folic acid, and dietary supplements were used with treatment. So, this review article helps the researcher’s to understand the basic overview of rheumatoid arthritis, causes, other disease development, and management process with regards to available FDA approved therapeutics, and published patents.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"42 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80092021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asian Journal of Pharmaceutical Research","authors":"S. Hasni, A. Khelil, Salma Habita, K. Bireche, Zineb Mahcene, Z. Boual, Abdulatef M Ahhmed","doi":"10.52711/2231-5691","DOIUrl":"https://doi.org/10.52711/2231-5691","url":null,"abstract":"Camel urine has been widely used in the biomedical field as a traditional healing liquid for several health disorders, this study aims to evaluate the antioxidant activity of camel urine and its association with the breeding and the feeding system. Urine samples were collected from domestic (from private farms) and desertic camels, where spectrophotometric method was chosen to evaluate the phenolic, flavonoid content and the antioxidant activity. As results, it was found from the applied testes that the antioxidant activity of the camel urine is very important, where both types of urine illustrated a very low EC50. However, it has been found that the significant anti-radical activity and a reducing power of urine of domesticated camels fed in private farms was higher than the urine of desertic camels. concluding that the consumption and usage of camel urine can contribute to the prevention of diseases associated with oxidative stress.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"194 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72649005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude and Practice towards Haemovigilance among Health care Professionals in North Karnataka","authors":"B. K. M, A. Parveen, Nikita Biradar, Naman Kumar Jain, Aniket N Pund, D. H","doi":"10.52711/2231-5691.2022.00046","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00046","url":null,"abstract":"Haemovigilance Programme of India was launched in 2012 with the purpose to identify, analyse and learn the complications related to transfusion and blood donation, in order to avoid such complications in future. It is essential to identify the adverse transfusion reactions to reduce the incidence and make transfusion easier. Thereare rare reports available about knowledge, attitude, and practice of healthcare professionals towards haemovigilance. A prospective questionnaire survey was conducted for a period of three months in 100 Healthcare Professionals. Data was collected using pre-validated questionnaire and that questionnaire emphasized on knowledge, attitude and practice of healthcare professionals towards haemovigilance. Data was analysed using descriptive statistics. From all the Participants, most of them were in the age group of 20-30 years i.e., 64% and 36% were physicians and 34% pharmacists. Among them 67% were aware about Haemovigilance and 64% did not have knowledge about how to report transfusion reaction. From the depicted results 44% had documented blood transfusion reaction, 56% didn’t document. Factors discouraging reaction, 56% of them had fear of consequences and 56% healthcare professionals said that due to lack of time they didn’t report any transfusion reaction. 86% participants opted thathealth care professionals should be trained in reporting. Most of healthcare professionals have a positive attitude towards transfusion reaction reporting but knowledge regarding the haemovigilance concept was poor and the majority of them never reported adverse transfusion reaction. There is a need for training program to strengthen the haemovigilance system, especially adverse transfusion reaction reporting.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76662971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audit Trail in Pharma: A Review","authors":"Amitabh S Saxena","doi":"10.52711/2231-5691.2022.00056","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00056","url":null,"abstract":"“Audit trail” (also known as audit log) management in the pharmaceutical industry has become an integral part of the quality system because of the current international regulatory demand associated with a pharmaceutical product. Regulators, industry, and standards-setting organizations have recognized the significance of an audit trail, as it is associated with data integrity problems. Industries need to rely more on a risk-based approach to the review of audit trails and establish more nimble and flexible standards to complement these efforts. Pharmaceutical audits by governing bodies issued warning letters to many companies, and they have recognized that quality needs to be built into systems and processes throughout the lifecycle of the product. The audit trails feature is a key source and helps manufacturers to minimize the risk, to maintain the reliability, and security of electronic data to recover lost data. The review study shares some insight into the anatomy of an audit trail, what are its benefits, its types, features, regulatory guidance that are associated with various regulatory agencies, the review of an audit trail, and how to best comply with the audit trail. This article reiterates an interpretation that an audit trail feature plays a vital role to assure compliance.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73774668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Warning letters Issued by US FDA Over 2019-2021","authors":"Ashok B. Patel, Bhumi K. Jinja, Amit Kumar J. Vyas, Nilesh K. Patel, Ajay I. Patel, Devang B. Sheth, Sunny R. Shah","doi":"10.52711/2231-5691.2022.00048","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00048","url":null,"abstract":"The United States Food and Drug Administration (US FDA) is a department of health and human services federal agency. If the FDA notices major violations of federal regulations, it sends warning letters to pharmaceutical makers, distributors, and clinical investigators. The nature of the infractions discovered, as well as the FDA's proposed corrective activities, are detailed in these warning letters. Following the completion of the corrective activities, the recipient may request a follow-up inspection. This review article examines the current state of warning letters issued by the US Food and Drug Administration (FDA) from 2019 to 2021. The main goal of this study is to examine warning letters related to drug and determine what the significant violations.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76279695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Head and Neck Cancer by Rajyoga: Spiritual Healing","authors":"B. Kumar, Suraj Kumar, Jogander Singh, Niranjan Niranjan, Ritika Gupta","doi":"10.52711/2231-5691.2022.00047","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00047","url":null,"abstract":"Cancer is one of the most dreaded diseases of human beings and is a major cause of death. In cancer cells loose the property of contact inhibition and they undergo uncontrolled growth. As a result of this cancerous cells just continue to divide giving rise to masses of cells called Tumor. There are two types of tumor Benign and malignant. Various causes involve physical, chemical, or biological agents called carcinogens for example x-ray, UV rays, tobacco smoke, certain viruses like HPV. Cancer detection is done mainly by radiography, antibodies against cancer-specific cells. Cancer Healing By Raj Yoga.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91129562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets","authors":"Sanjay S. Patel, Siddhi V. Shah","doi":"10.52711/2231-5691.2022.00052","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00052","url":null,"abstract":"Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property in dosage form can be attained by addition of different varieties of excipients. But the number of fillers/binders/disintegrant which can be used for ODT formulations is limited because these bulk excipients have to fulfill special requirements, such as being soluble in water, pleasant taste, mouth feel, sweetness, and rapid dispersibility. In recent years drug formulation scientists have recognized that single component excipients do not always provide the requisite performance to allow certain active pharmaceutical ingredients to be formulated or manufactured adequately. New combinations of existing excipients are an interesting option for improving excipient functionality now a day. In excipients mannitol is used as diluents but now a day’s modified mannitol is available which give extensive flow, compression and rapid dispersibility to the tablet e.g. like Orocell, Mannogem EZ, and Pearlitol SD 200. The current review article is prepared to have a look over the recent development in excipient technology and the approaches involved in development of such excipients. It emphasizes on the different examples of functionality added materialsalso called as multifunctional co processed excipients available in market such as Ludiflash, Pharmburst, and F- MELT.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78724312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Characterization of Hydrogel containing Finasteride","authors":"Wajid Ahmad, Rihan Jawed","doi":"10.52711/2231-5691.2022.00045","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00045","url":null,"abstract":"The major goal of this study was to create a controlled-release dosage form utilizing a cellulose-based hydrogel that was cross-linked with propylene glycol. Hydrogels were made by crosslinking the polymer Sodium Alginate + Na CMC with propylene glycol, a suitable crosslinking agent. There is no indication of interaction between the medication, polymers, and other excipients, according to an IR and DSC analysis. The hydrogel gave good swelling and controlled release properties due to the cross linking process. The effect of Calcium Chloride concentration on drug content and t75 percent CDR was found to be non-significant based on the findings. However, the influence of Calcium Chloride concentration on swelling index was substantial, indicating that as Calcium Chloride concentration rose, the swelling index of the hydrogel decreased. Again, the effect of response time on drug content and t75 of percent CDR was substantial, implying that as reaction time rose, drug content and t75 of percent CDR of hydrogel increased as well. However, the effect of response time on the swelling index was not statistically significant. Drug content, swelling index, and t75 of percent CDR of run BB1 are the best than compared with based on all responses. This run's drug content, swelling index, and t75 percent CDR are respectively 99.5 percent, 276.64 percent, and 3.5 hrs. So BB1 was used to test the improved formulation, which produced the best in vitro release of 94.24 percent in 6hrs. Different kinetic models were fitted to the in vitro data which showed the best model was higuchi with non-fickian mode of drug release and stability data showed that the formulations were stable during the time span of the study. From the study it was concluded that the prepared hydrogel can provide a sustained release effect with better bioavailability which will surely enhance its absorption throughout the body.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81450241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}