Asian Journal of Pharmaceutical Research最新文献_第10页

Evaluation of Prokaryotic and Eukaryotic Cell 原核和真核细胞的评价

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00036

Ravi Kumar

引用次数: 1

A Role of Herbal Drug as an Immunity Booster during Covid-19 Pandemic 中药在Covid-19大流行期间的免疫增强作用

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00037

Dhanashri Aware, S. Rohane

引用次数: 7

Medical device’s regulation in South-East Asian countries: Current status and gap areas 东南亚国家的医疗器械法规:现状和差距

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00032

V. Kalaiselvan, Gautam Aishwarya, Ashish Sharma

{"title":"Medical device’s regulation in South-East Asian countries: \u0000Current status and gap areas","authors":"V. Kalaiselvan, Gautam Aishwarya, Ashish Sharma","doi":"10.52711/2231-5691.2021.00032","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00032","url":null,"abstract":"As Medical device application in disease prevention, diagnosis or treatment is evolving to a greater extent; there is a need for regulation to monitor its quality, safety and efficacy. The present article attempts to study the medical device regulation available in eleven South-East Asian World Health Organization (WHO) member countries. The information searched from the available sources reveals that medical device regulation exists in seven countries. Most of the countries follow the International Organization for Standardization (ISO) 13485 for their quality standards in medical devices. Most countries also specified the time frame and authority to which adverse event is to be reported. Countries like India and Thailand have separate Adverse Event reporting forms for the medical device. The present study reveals that there is no separate web-based database for adverse event reporting of medical devices. Therefore, WHO South-East Asian Regulators Network (SEARN) under South East Regulatory Office (SERO) office may provide handholding support to these regions in developing a common software or tool for the management and analysis of signals arising from the adverse events.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74063149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Laconic Review on Liquid Chromatography Mass Spectrometry (LC-MS) Based Proteomics Technology in Drug Discovery 基于液相色谱-质谱(LC-MS)的蛋白质组学技术在药物发现中的应用综述

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00035

Shivani Sharma, Navdeep Singh, A. Ankalgi, Arti Rana, Mahendra Singh Ashawat

{"title":"A Laconic Review on Liquid Chromatography Mass Spectrometry \u0000(LC-MS) Based Proteomics Technology in Drug Discovery","authors":"Shivani Sharma, Navdeep Singh, A. Ankalgi, Arti Rana, Mahendra Singh Ashawat","doi":"10.52711/2231-5691.2021.00035","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00035","url":null,"abstract":"Liquid chromatography mass spectrometry is a powerful technique which is used for the new product development, manufacturing, and to the control the stability or drug abuse. These techniques were commonly preferred in pharmacokinetics studies in pharmaceutical products. The principle involved in the LC-MS technique was justified in our study to understand the basic fundamentals of LC-MS. Also, it is used in combination with HPLC for chemical analysis. Many applications and the future prospects have been highlighted regarding the use for LC-MS in analytical chemistry. It is basically depends on the metabolites which are collected in this technique, furthermore the chemicals are analyzed according to the nature of suitability of LC-MS. This technique was helpful in the analysis of protein components identified in terms of pharmacovigilance, organic/inorganic hybrid nanoflowering. Also, our study highlights the techniques involved in proteomics. In LC-MS-based proteomics, complex mixtures of proteins are first subjected to enzymatic cleavage, then the resulting peptide products are analyzed using a mass spectrometer; this is in contrast to \"top-down\" proteomics, which deals with intact proteins and is limited to single protein mixtures. So, this review aims to highlight the basic introduction, and principle involved in liquid chromatography-mass spectrometry (LC-MS). Also, the advantages, or application of LC-MS were studied. Most importantly the LC-MS based proteomics, and the future aspects of LC-MS technology were studied in this review.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"76 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91467786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

UV Spectrophotometric Method Development and Validation of Carbimazole in Bulk and Tablet Dosage form 卡马唑片剂和散装剂型的紫外分光光度法研究与验证

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00030

Zainab A. Bagalkote, G. Gajeli

引用次数: 3

Phytochemical and Chromatographic studies of two Ayurvedic source plants of Somalata, Cynanchum viminale and Ceropegia juncea 两种阿育吠陀来源植物索马拉的植物化学和色谱研究:Cynanchum viminale和Ceropegia juncea

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00029

M. Deepak, C. Sulaiman, M. Athulya, I. Balachandran

{"title":"Phytochemical and Chromatographic studies of two Ayurvedic source plants of Somalata, Cynanchum viminale and Ceropegia juncea","authors":"M. Deepak, C. Sulaiman, M. Athulya, I. Balachandran","doi":"10.52711/2231-5691.2021.00029","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00029","url":null,"abstract":"Soma is an important Ayurvedic drug used for various therapeutic aspects. Botanical identity of the source plant of Soma is a matter of controversy. Different plants are being used under the name Soma in different regions of India. Cynanchum viminale and Ceropegia juncea are being used as two important source plants of Soma. In this study, these two plants were compared phytochemically using various quantitative assays and chromatographic techniques like High Performance Thin Layer Chromatography and High-Performance Liquid Chromatography. On quantitative assays C. viminale showed higher flavonoid content whereas C. juncea showed higher percentage of phenolics, carbohydrates and amino acid contents. Presence of a terpenoid and a steroid was identified in plants using high performance thin layer chromatography and both plants showed similar steroids and terpenoids profile. Detailed chromatographic studies revealed that the source plants of Somalata such as C. viminale and C. juncea are almost similar in their phytochemical profiles. The study provided a scientific background for the traditional use of C. viminale and C. juncea as source plants of somalata.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85712598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats 植物丝达醇提物对卡拉胶致大鼠足跖水肿的镇痛和抗炎作用

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00027

Prajakta P Shinde, Shahu D Khule, S. Sonawane, Suvarna J. Shelke

{"title":"Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats","authors":"Prajakta P Shinde, Shahu D Khule, S. Sonawane, Suvarna J. Shelke","doi":"10.52711/2231-5691.2021.00027","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00027","url":null,"abstract":"India has rich heritage of use of medicinal plants in clinical practices since ancient times. Diabetes mellitus is a group of syndromes characterized by hyperglycemia, altered lipid, carbohydrate and protein metabolism, and an increased risk of vascular disease complications. More than 400 plant species have been recorded to display hypoglycemic effects, but only a few of them have been investigated. Although many drugs are available to control the diabetes but has several adverse effects. The plant Sida cordata activities have been reported such as Antibacterial, Antitumor, Antifungal, Antiulcer, Antitussive, Anti-inflammatory, Anti-malarial, Anti-oxidant, Analgesic, Antidepressant, Antihyperglycemic, Hepatoprotective in ayurvedic system of medicine. This research was conducted undertaken In order to investigate the anti-diabetic activity of methnolic extract of Sida cordata. The two dose (100 and 200 mg/kg) methnolic extract of Sida cordata used for treatment of Alloxan induced diabetic rats. The glucose level was significantly (p<0.01) high in Alloxan control rats when opposed to normal control. But the level of glucose was significantly (p<0.01) decreased after 7th day in diabetic rats treated with methanol extract (200 mg/kg) as compared with diabetic control rats.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73085375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mouth Dissolving Tablet: A Novel Drug Delivery System 口腔溶片:一种新型给药系统

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00033

Davesh S. Jire, Nitin S. Gosavi, Roshan B. Badhe, Dipak H. Jagdale

引用次数: 8

Therapeutic effect of certain Indian medicinal compounds against the Corona Virus: An in-silico study 某些印度药物化合物对冠状病毒的治疗效果:一项计算机研究

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00031

Sakshi Nand, Neelabh

{"title":"Therapeutic effect of certain Indian medicinal compounds against the Corona Virus: An in-silico study","authors":"Sakshi Nand, Neelabh","doi":"10.52711/2231-5691.2021.00031","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00031","url":null,"abstract":"Introduction: Since Covid-19 has emerged as a pandemic, it has taken innumerable lives and caused havoc in the developing as well as developed countries. The health facilities throughout the world have taken a toll and to counter this some immediate alternative measures have to be taken. Utilization of the plant-based products from the Indian traditional medicine can be one such measure. Methods: NCBI, Pubchem and PDB databases were used to obtain the structures of the relevant protein targets and plant-based ligands. Apart from this, softwares such as Open Babel, UCSF Chimera, PatchDock and FireDock were used for the purpose of interconversion of file formats, visualization of the structures and docking respectively. Results: After the screening of 9 plant-based products against the 3 main protein targets (spike protein, hemagglutinin, nucleocapsid) of corona virus we found that glucoraphanin showed the best binding energy against spike protein (-51.44 KJ/mol), alpha amyrin showed the best binding energy against hemagglutinin (-31.76 KJ/mol) and beta-sitosterol showed best binding energy against nucleocapsid (-55.44 KJ/mol). Conclusion: This study would aid in the speedy recovery and better immune response of the corona virus infected patients.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88316753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Brief Review on Genotoxic impurities in Pharmaceuticals 药物中基因毒性杂质的研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2021-08-14 DOI: 10.52711/2231-5691.2021.00034

A. Patel, Ashish H. Asnani, A. Vyas, Nilesh Patel, Ajay I. Patel, Arvind N. Lumbhani

引用次数: 12