Asian Journal of Pharmaceutical Research最新文献

{"title":"Emulgel: A Review","authors":"Sahil Hasan, Saloni Bhandari, Ankita Sharma, Poonam Garg","doi":"10.52711/2231-5691.2021.00047","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00047","url":null,"abstract":"Emulgel systems are currently attention to the pharmaceutical sectors because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules and higher stability compared to the other dosage form like cream, lotion, gel, etc. Emulsions are either available in an oil in water or water in oil type. These are prepared by the incorporation of the emulsion into the gel with constant stirring at a moderate speed. Incorporation of emulsion into a gel makes it a dual control release system, thereby, increasing its stability. It has better drug release if we compare to other topical drug delivery system. It is non greasy because of the presence of gel phase which enhances patient compliance. Gels has a major limitation for the delivery of hydrophobic drugs, so to overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic drug can enjoy the unique properties of gels. In recent years, these have also been a great interest in the use of novel polymers. These emulgels are having major advantages on vesicular drug delivery systems as well as on conventional systems in various aspects. Various permeation enhancers can enhance the effect; due to this emulgels can be used as better topical drug delivery systems over current drug delivery systems. The emulsion can be use for analgesics and antifungal drugs.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"267 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79550909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relugolix is the first and currently only Orally-Administered GnRH Receptor Antagonist Approved for the treatment of Prostate Cancer:\u0000A Review","authors":"S. Bavaskar, Mayur Bhurat","doi":"10.52711/2231-5691.2021.00043","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00043","url":null,"abstract":"Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under the brand name Orgovyx, for the treatment of advanced prostate cancer. Relugolix has also been studied in the symptomatic treatment of endometriosis. Relugolix is the first (and currently only) orally-administered GnRH receptor antagonist approved for the treatment of prostate cancer-similar therapies such as degarelix require subcutaneous administration-and therefore provides a less burdensome therapeutic option for patients who might otherwise require clinic visits for administration by healthcare professionals.In addition to its relative ease-of-use, relugolix was shown to be superior in the depression of testosterone levels when compared to leuprolide, another androgen deprivation therapy used in the treatment of prostate cancer1,2","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83029936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Solid Self Nano Emulsifying drug delivery System of Olanzapine to Enhance Aqueous Solubility and Dissolution Rate","authors":"M. Reddy, Baskarla Sravani","doi":"10.52711/2231-5691.2021.00040","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00040","url":null,"abstract":"Present research work was aimed to enhance aqueous solubility and dissolution rate of olanzapine by solid self nano emulsifying drug delivery system(S-SNEDDS). Olanzapine is a BCS class II drug having 65% oral bioavailability; it is used in the treatment of psychosis, depression and mania conditions. Oils, Surfactants, Co surfactants were selected depending upon the saturated solubility of olanzapine in those components; excipients were screened depending on olanzapine solubility in various oils, surfactants and co surfactants. Surfactant: co surfactant {Smix} ratios i.e., 3:1 and 4:1 were prepared to determine nano emulsion regions and also to formulate liquid self nano emulsifying drug delivery system (L-SNEDDS). Pseudo ternary phase diagram were plotted by using Triplot version 4.1.2 software, nano emulsion region was determined and evaluated. Formulations were designed based on saturated solubility of olanzapine and Pseudo ternary phase diagram using various ratios of oils [Capryol 90], surfactants [Kolliphor EL], co surfactants [Lauroglycol 90] depending on its solubility and nano emulsion formation four formulations were developed which are further selected for characterisation of L-SNEDDS like robustness to dilution, self emulsification, determination of droplet size, PDI, Drug loading efficacy, zeta potential and also Invitro drug release. Among those four formulations, F1 (SB184J 4:6) was optimum because compared to other three formulations F3 gave best results in terms of droplet size (66nm) with PDI (0.24), Invitro drug release, dissolution rate of F1 SNEDDS having (88.201± 0.25%). Invitro drug release of F1 formulation was compared with that of Olanzapine [API] (45.281± 0.52%) the results indicating that there is a increase in solubility and dissolution rate of olanzapine by 2.2 times more compared to pure olanzapine (API). F1 (SB184J 4:6) were converted into S-SNEDDS by adsorption process by addition porous carriers (Aerosil 200). Formulated S-SNEDDS were undergone various evaluation parameters and also reconstitution parameters to determine Droplet size and Invitro drug release of solid F1 (SB184J4:6) formulation. The results of present study demonstrates that olanzapine SNEDDS has an ability and potential to enhance solubility and dissolution rate.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75608636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic Review of Aloe vera and its Properties","authors":"Farha Fatma, Anil Kumar","doi":"10.52711/2231-5691.2021.00045","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00045","url":null,"abstract":"Aloe vera is one of the oldest medicinal plant ever known, commonly known as Ghrit Kumari. It is well known for its therapeutic potential. Some of its beneficial effects include anticancer, hypoglycemic, antifungal, anti-inflammatory, burn healing properties. Phytochemistry of Aloe vera gel has revealed presence of bioactive chemicals. In this review paper, properties of Aloe vera, its composition, its beneficial effects and pharmaceutical uses, its application in foods and cosmetics etc. have been summarized.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73069008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Toxicity study of Synthesized drug and Herbal Product","authors":"Tanuja T. Yadav, S. Rohane","doi":"10.52711/2231-5691.2021.00044","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00044","url":null,"abstract":"Acute toxicity study describes the adverse effects of a substance that result either from a single exposure or from multiple exposures in a short period of time. Whenever an investigator administered a chemical substance or herbal drug to a biological system different types of interactions can occur and a series of dose-related responses result. In most cases these responses are desired and useful, but there are a number of other effects which are not advantageous. These may or may not be harmful to the patient. Acute toxicity study is involved in estimation of LD50. Also it determines the therapeutic index i.e ratio between the lethal dose and the pharmacologically effective dose in the same strain and species. This article Review the methods so for utilized for the determination of acute toxicity.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88786475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Composition of Gmelina arborea: A Review","authors":"Y. Chowdhary","doi":"10.52711/2231-5691.2021.00048","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00048","url":null,"abstract":"Gmelina arborea is a fast-growing tree, which grows on different localities and prefers moist fertile valleys with 750–4500 mm rainfall. It does not thrive on ill-drained soils and remains stunted on dry, sandy or poor soils; drought also reduces it to a shrubby form. The tree attains moderate to large heights of up to 30 m, with a girth of 1.2 to 4 m. It has a chlorophyll layer just under the outer bark, which is pale yellow on the outside and white inside.Gmelina arborea wood is pale yellow to cream-coloured or pinkish-buff when fresh, turning yellowish brown on exposure and is soft to moderately hard, light to moderately heavy, lustrous when fresh, usually straight to irregular or rarely wavy grained and medium course textured. Flowering takes place during February to April when the tree is more or less leafless whereas fruiting starts from May onwards up to June. The fruit is up to 2.5 cm long, smooth, dark green, turning yellow when ripe and has a fruity smell. The fruit is edible and has a bitter-sweet taste.4 This tree is commonly planted as a garden and an avenue tree; growing in villages along agricultural land and on village community lands and wastelands. It is light demander, tolerant of excessive drought, but moderately frost hardy. It has good capacity to recover from frost injury. Gamhar trees coppices very well with vigorous growth. Saplings and young plants need protection from deer and cattle. Gmelina arborea grows naturally throughout India, Myanmar, Thailand, Laos, Cambodia, Vietnam and in southern provinces of China","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89077912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of calcium Starch: A New Controlled Release Polymer for floating tablets of Losartan Potassium","authors":"K. Prathyusha, B. Hemalatha, K. Padmalatha","doi":"10.52711/2231-5691.2021.00039","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00039","url":null,"abstract":"Losartan potassium is used to treat high blood pressure (hypertension). The present study was aimed to prepare a floating drug delivery system to design a controlled release oral dosage form of Losartan potassium. This helps to overcome the demerit of limited residence time of the drug in the gastrointestinal track and hence to increase the duration of release. Hence objective of the present study is to develop Losartan potassium floating tablets by direct compression method using calcium starch as release retarding polymer. The calcium starch was synthesized by gelatinizing potato starch in the presence of sodium hydroxide and cross linking by treatment with calcium chloride. The micromeritic properties studies indicated that calcium starch is a promising pharmaceutical excipient in tablets. Floating tablets of Losartan potassium was formulated by direct compression technique, using different concentration of calcium starch and compared with HPMC K-100 as release retard polymer. As the amount of calcium starch in the tablet increased, the drug release decreased. The formulation F5 containing 125 mg calcium starch showed better controlled release of 76.38% after 12 hours.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87737412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Enhydra Fluctuans","authors":"C. Sonawane, Atul A. Patil, Vikrant M Patil, P. Patil","doi":"10.52711/2231-5691.2021.00046","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00046","url":null,"abstract":"Medicinal plants have played an important role since ancient times in treating various kinds of diseases. Increased drug resistance and side effects of pharmaceutical drugs have led to more research-based study on traditionally available plants. Enhydra fluctuans is one such plant which is available abundantly in India especially in the North-Eastern states. It has immense potential as a medicinal plant and also has many beneficial effects such as anticancer, antioxidant, antidiabetic, anti-inflammatory, antimicrobial, anti-diarrheal, hepatoprotective and even neuropharmacological effects. These activities can be attributed mainly to the presence of phytochemicals such as flavonoids, alkaloids, saponins, tannins, phenols and carbohydrates. The aim of this paper is to summarize the importance of this plant possessing potent medicinal value and the research work being carried out till now.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87751097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method of Validation for Residual Solvents in Bisoprolol Fumarate by GC Technique","authors":"Sandip A. Telavane, S. Kothari, Manohar V. Lokhande","doi":"10.52711/2231-5691.2021.00028","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00028","url":null,"abstract":"Validation is important technique for detection, progress and estimation of drugs for pharmaceutical analysis. Aim of this article was to check the progress and validation of the method employed for the Residual Solvents in Bisoprolol Fumarate by Gas Chromatographic technique. The objective of this protocol is to validate a GC method of analysis for detection and Quantification of Residual Solvents Methanol, Acetone and Methylene dichloride in Bisoprolol Fumarate. In the pharmaceutical industry, validation policy is more important for documented of validation, types of validation and validation policy. The method was developed accurately and validation parameters are explained. Chromatographic condition was GC- 2014, gas chromatograph equipped with FID detector, column: 30 m x 0.32 mm ID x 1.8 µm DB - 624 capillary column or equivalent and column temperature was 45°C (hold 7 minutes) to 250°C @ 40°C/minutes, hold at 250°C for 3 minutes. The parameters such as Accuracy, Specificity, Precision, Linearity and Range, Limit of detection (LOD), Limit of quantitation (LOQ), ruggedness, robustness and system suitability testing with residual solvent such as Methanol, Acetone and methylene dichloride. All validation parameters are used in the routine and stability analysis.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86381136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immuno-Boosters as Health Accelerants to Tackle Viral Infections","authors":"H. Ahad, C. Haranath, Ksheerasagare Tarun, J. Krishna, N. Chandana, Boya Indrani","doi":"10.52711/2231-5691.2021.00038","DOIUrl":"https://doi.org/10.52711/2231-5691.2021.00038","url":null,"abstract":"The immune framework is one of nature's most entrancing creations. It is an astonishing assurance system intended to protect us against many microorganisms, infections, organisms, poisons and parasites. The immune framework is intricate. It is comprised of a few sorts of cells and proteins that have various tasks to take care of in battling against unfamiliar trespassers. On the off chance that the immune framework is working appropriately, we are shielded from perils brought about by organisms. If not, we endure disorder and illness. It is conceivable to intercede in this cycle and make our immune framework more grounded utilizing immune sponsors. Immune supporters work from various perspectives. They increment the number of white platelets in the immune framework armed force, train them to battle against microorganisms causing illnesses. This audit article gives a general view about some significant way of life and food propensities that support resistance.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"178 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85188642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}