Asian Journal of Pharmaceutical Research最新文献

Recent Advances on Chitosan Nanoparticles 壳聚糖纳米颗粒研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00030

Aamir Nazir, Neha Kumari, Nitan Bharti Gupta, Rajesh Gupta, Ashima Chandel, Abi C. Varghese

{"title":"Recent Advances on Chitosan Nanoparticles","authors":"Aamir Nazir, Neha Kumari, Nitan Bharti Gupta, Rajesh Gupta, Ashima Chandel, Abi C. Varghese","doi":"10.52711/2231-5691.2023.00030","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00030","url":null,"abstract":"The focal point of this survey is to give an outline of the chitosan based nanoparticles for different non-parenteral applications and furthermore to put a focus on flow research including supported delivery and mucoadhesive chitosan measurement structures. Chitosan is a biodegradable, biocompatible polymer viewed as safe for human dietary use and endorsed for wound dressing applications. Chitosan has been utilized as a transporter in polymeric nanoparticles for drug conveyance through different courses of organization. Chitosan has synthetic useful gatherings that can be adjusted to accomplish explicit objectives, making it a polymer with an enormous scope of expected applications. Nanoparticles (NP) ready with chitosan and chitosan subsidiaries ordinarily have a positive surface charge and mucoadhesive properties to such an extent that can hold fast to bodily fluid films and delivery the medication payload in a supported delivery way. Chitosan-based NP have different applications in non-parenteral medication conveyance for the therapy of malignant growth, gastrointestinal illnesses, aspiratory sicknesses, drug conveyance to the mind and visual contaminations which will be exemplified in this survey. Chitosan shows low poisonousness both in vitro and some in vivo models. This survey investigates ongoing exploration on chitosan based NP for non-parenteral medication conveyance, chitosan properties, adjustment, poisonousness, pharmacokinetics and preclinical examinations.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135097466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperlipidaemia: A Review of Literature 高脂血症:文献综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00033

Swapnil S. Lad, Swati U. Kolhe, Omkar A. Devade, Asawari P. Mansabdar

引用次数: 0

Design, Synthesis, Characterization and Non-steroidal Anti-Inflammatory Activity of Novel Oxazolone Derivatives 新型恶唑酮衍生物的设计、合成、表征及其非甾体抗炎活性

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00028

G. Muthubhupathi, M. Selvakumar, S. Navi Shree, C. Nisha, P. Sathiya Priya, P. A. Varshini

引用次数: 0

Molecular Docking: A useful approach of Drug Discovery on the Basis of their Structure 分子对接:一种基于结构的药物发现方法

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00036

Vishwajit S. Patil, Prithviraj A. Patil

引用次数: 0

Drug use Pattern with Standard Indicators in Chattogram Medical College Hospital in Bangladesh 孟加拉Chattogram医学院医院标准指标用药模式

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00029

Iva Moni, Atashi Saha, Marzina Ajrin

{"title":"Drug use Pattern with Standard Indicators in Chattogram Medical College Hospital in Bangladesh","authors":"Iva Moni, Atashi Saha, Marzina Ajrin","doi":"10.52711/2231-5691.2023.00029","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00029","url":null,"abstract":"Irrational prescription being a global problem leading to ineffective, unsafe treatment. This study was conducted between November 10, 2019 to January 20, 2020 to assess drug use pattern using WHO/INRUD core prescribing indicators at Chattogram Medical College Hospital (CMCH). Total 500 patients were selected randomly. The results showed average number of drugs per encounter is 4.41 (optimal range = 1.6–1.8), generic drug prescription was 1.54% (optimal value = 100%), encounters with an antibiotic prescribed were 32.6% (optimal range =20.0–26.8%), encounters with an injection prescribed were 24.8% (optimal range =13.4–24.1%), drugs prescribed from EDL were 50.43% (optimal value = 100%) and drugs prescribed from the WHO EDL were 56.96% (optimal value = 100%). Average consultation time was 3.1 min (optimal value ≥10 min), average dispensing time was 35 s (optimal value ≥90 s) and the patients’ knowledge of correct dosage was 62.1% (optimal value =100%. The hospital had no copy of EDL and key drugs available in the stock were 82% (optimal value =100%). The concept of generic prescribing was negligible. There was reduced prescription of drugs from the National List of Essential Medicines, the prescription of antibiotics and injections was slightly higher than normal. Shorter consultation and dispensing time may lead to inadequate information about the medication being given to patients and patients had little chance to obtain information about their treatment. This study necessitates we are in need of strict scrutiny on the prescribing method of our country. So, we can achieve the goal of rational use of drug.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135097457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo and In vitro Model for Evaluation of Anti-microbial activity: A Review 体外和体内抗微生物活性评价模型的研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00032

Saema Saema, Tabassum Wasim Ahmed, Peeyush Kumar Sharma, Imran Khan Pathan, Mamta Bhatia, Marhaba Khan

引用次数: 0

A Review on Drug Addiction and Drug Abuse 药物成瘾与药物滥用研究综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00035

Subhashis Debnath, Donita Devi, Aikyrmen K Dewsaw

引用次数: 0

Simultaneous Estimation of Adapalene from Marketed Gel Formulation along with the Preservative Phenoxyethanol by UV- Visible Spectroscopy 紫外可见光谱法同时测定市售凝胶制剂中阿达帕烯和防腐剂苯氧乙醇的含量

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00039

Tejasvini Neve, Vijaya Vichare, Manasi Rokade, S.N. Dhole

引用次数: 0

A Study to Evaluate the Neuroprotective property of Aqueous Extract of Mentha piperita Leaves on Haloperidol Induced Parkinsonism in Experimental rats 薄荷叶水提物对氟哌啶醇致帕金森大鼠神经保护作用的研究

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00027

Naveen K L, Ananya Bhattacharjee, Karunakar Hegde

{"title":"A Study to Evaluate the Neuroprotective property of Aqueous Extract of Mentha piperita Leaves on Haloperidol Induced Parkinsonism in Experimental rats","authors":"Naveen K L, Ananya Bhattacharjee, Karunakar Hegde","doi":"10.52711/2231-5691.2023.00027","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00027","url":null,"abstract":"The main objective of the proposed study was designed to investigate the neuroprotective property of aqueous extract of the Mentha piperita leaves (AEMPL) against haloperidol induced Parkinsonism in experimental animals. Rats were divided into 5 groups (n=6 animals). Group 1 received vehicle control, Group 2 received Haloperidol (1mg/kg, i.p.), Group 3receivedstandard drug Sinemet (125mg/kg p.o.), Group4andGroup5treated with lower (100mg/kg, p.o.) and higher (250mg/kg, p.o.) doses of AEMPL respectively for 14 days. Later motor co-ordination (rota-rod), locomotor activity (actophotometer) and catalepsy bar test was performed and also brain histopathological examination was also done. Both the lower and higher doses of aqueous extract of Mentha piperita leaves showed dose dependent, extremely significant increases in locomotor activity by increasing number of cuts, decreases fall off time and also decreases in latency period in metal bar test, histopathological examination shows reduction in neuronal loss and normal brain architecture was observed when compared haloperidol treated group. Hence Mentha piperita shows neuroprotective activity because of potential anti-oxidant property. The obtained result was comparable with that of the standard drug levodopa+carbidopa (Sinemet). The outcome of the present study provides the evidence that the aqueous extract of Mentha piperita leaves reported that it has dose dependent beneficial neuroprotective effect against haloperidol induced Parkinson’s disease in experimental rats.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135097458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Microspheres as Controlled Release Drug Delivery 微球缓释给药研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00031

Malay Paul, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP

{"title":"A Review on Microspheres as Controlled Release Drug Delivery","authors":"Malay Paul, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP","doi":"10.52711/2231-5691.2023.00031","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00031","url":null,"abstract":"Microspheres play a totally critical function as a particulate drug transport machine due to theirtiny size and different properties. Microspheres proved an appropriate bridge to scale the gap over to formulate a powerful dosage form, to managed drug release, to simulate controlled drug release. Microspheres are often free-flowing stable powders, which include proteins or artificial polymers, which can be biodegradable. Microspheres having a particle size in the range of 0.1-800µm, can be delivered by several routes like oral, parenteral, nasal, ophthalmic, transdermal, colonal, etc. Various recent advancements in the case of microspheres like mucoadhesive, hollow, floating, micro balloons, and magnetic have contributed to overcoming the diverse troubles which might be related to using microspheres, which incorporates site-precise focused on and stepped forward release. In the future by combining various new designing, planning’s, and strategies, microspheres will find a central place in novel drug delivery, especially in diseased molecular sorting, genetic materials, safe, targeting, and powerful drug delivery.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135097459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0