微球缓释给药研究进展

Malay Paul, H. S Keerthy, Mukesh Sharma, Pradeep Kumar Patel, Sowmya TP
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引用次数: 0

摘要

微球由于其微小的尺寸和不同的性质,在颗粒药物运输中起着至关重要的作用。事实证明,微球是一个适当的桥梁,可以缩小差距,形成强大的剂型,管理药物释放,模拟受控药物释放。微球通常是自由流动的稳定粉末,其中包括蛋白质或人工聚合物,可以生物降解。微球的粒径范围为0.1-800µm,可通过口服、肠外、鼻、眼、透皮、结肠等多种途径给药。微球的各种最新进展,如粘接、中空、漂浮、微气球和磁性,有助于克服使用微球可能遇到的各种问题,其中包括精确定位和向前释放。在未来,通过结合各种新的设计、规划和策略,微球将在新型药物递送,特别是在疾病分子分选、遗传材料、安全、靶向和强大的药物递送中占据中心地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review on Microspheres as Controlled Release Drug Delivery
Microspheres play a totally critical function as a particulate drug transport machine due to theirtiny size and different properties. Microspheres proved an appropriate bridge to scale the gap over to formulate a powerful dosage form, to managed drug release, to simulate controlled drug release. Microspheres are often free-flowing stable powders, which include proteins or artificial polymers, which can be biodegradable. Microspheres having a particle size in the range of 0.1-800µm, can be delivered by several routes like oral, parenteral, nasal, ophthalmic, transdermal, colonal, etc. Various recent advancements in the case of microspheres like mucoadhesive, hollow, floating, micro balloons, and magnetic have contributed to overcoming the diverse troubles which might be related to using microspheres, which incorporates site-precise focused on and stepped forward release. In the future by combining various new designing, planning’s, and strategies, microspheres will find a central place in novel drug delivery, especially in diseased molecular sorting, genetic materials, safe, targeting, and powerful drug delivery.
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