Asian Journal of Pharmaceutical Research最新文献_第2页

Synthesis and Anticancer Activity of Bis-Thiosemicarbazone Complexes 双硫代氨基脲配合物的合成及抗癌活性研究

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00034

Muhammad Hamza Ashfaq

{"title":"Synthesis and Anticancer Activity of Bis-Thiosemicarbazone Complexes","authors":"Muhammad Hamza Ashfaq","doi":"10.52711/2231-5691.2023.00034","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00034","url":null,"abstract":"In a present review article, relationships were identified between the structure and activity of the bis-thiosemicarbazone ligands and their zinc and copper complexes. These compounds have different substituents at the diimine point and terminal nitrogen of the backbone. All the copper complexes showed distortion in geometry from square planar while all the zinc complexes showed distortion in geometry from square pyramidal. In electrochemistry determination by cyclic voltammetry, all the copper complexes were found quasi-reversible. When the antiproliferative activity was checked against tumor cells, copper complexes showed the greatest activity. It was seen that antiproliferative activity was decreased when hydrophobic moieties were present at diimine points and terminal nitrogen. Zinc complexes showed the lowest antiproliferative activity because they were failed in ligand delivery intracellularly as they were not chaperone. But cobalt showed good activity by successfully delivering the ligand acting as chaperone1. Copper complexes showed more antiproliferative activity as compared to the ligand. In the environment of the tumor, hypoxia was found which decreased the antiproliferative activity of the ligand and its copper complexes. In the present study, it was concluded that this relationship could be helpful in the synthesis of antitumor agents such as bis-thiosemicarbazone and its complexes.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135097460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview on Neonatal Jaundice 新生儿黄疸综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00038

V. Prema, K. Mohamed Rizwan, S. Tamilarasan

引用次数: 0

An Overview on Emulgel 乳凝胶概述

Asian Journal of Pharmaceutical Research Pub Date : 2023-09-07 DOI: 10.52711/2231-5691.2023.00037

Ashima Chandel, Neha Kumari, Rajesh Gupta, Aamir Nazir, Honey Honey, Abi C. Varghese

引用次数: 9

A Review on Biosimilar – A Medicine from the Life and for the Life 生物仿制药综述——一种从生命出发、为生命而生的药物

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00018

Dnyanda Kangude, S. Mankar

引用次数: 0

Evaluation of Antioxidant and Anti-inflamatory Activity of Ethanolic Extract of Glochidion acuminatum Leaves 荆芥叶乙醇提取物的抗氧化和抗炎活性评价

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00017

Md. Khalequeuzzaman, Shakib Al Hasan, Masoumul Haque, R. Parul, Mohammad Rezwanur Alam

{"title":"Evaluation of Antioxidant and Anti-inflamatory Activity of Ethanolic Extract of Glochidion acuminatum Leaves","authors":"Md. Khalequeuzzaman, Shakib Al Hasan, Masoumul Haque, R. Parul, Mohammad Rezwanur Alam","doi":"10.52711/2231-5691.2023.00017","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00017","url":null,"abstract":"The present study was undertaken to investigate the antioxidant and anti inflammatory activity of ethanolic extract of Glochidion acuminatum leaves. Ethanolic extract of the leaves of the plant was subjected to various in-vitro assays. Antioxidant potential was tested through total phenol content, total flavonoid content, DPPH free radical scavenging capacity and total anti-oxidant capacity assay. Anti-inflammatory activity was tested against the denaturation of protein. Glochidion acuminatum exhibited good antioxidant potential on total phenol content assay, TPC as GAE was 507.24±19.48mg/gm. It showed remarkable antioxidant potential on total flavonoid content assay, TFC as QE was 486.28±16.44mg/gm. In DPPH free radical scavenging assay IC50 value was 14.97μg/ml while for standard ascorbic acid it was found to be 8.87μg/ml which express potent antioxidant activity. It also showed excellent antioxidant potential on total antioxidant capacity assay, TAC as AAE was 712.5±5.89μg/ml. Anti-inflamatory assay showed that the plant leaves extract possess very good anti-inflamatory potential. These effects may be due to the presence of different phytoconstituents present in the extract. Further studies are required to evaluate these effects and due to the findings which warrants further more sophisticated research.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88573225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Pharmacist in Prevention and Management of Diabetics 药师在糖尿病预防管理中的作用

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00019

Sarika S. Lokhande, Raje V. N., S. More, S. Pawar

引用次数: 1

A Study on Pharmaceutical Drug Recall 药品召回研究

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00020

Bansi l. Bhalodiya, Amit Kumar J. Vyas, Ajay I. Patel, Ashvin V. Dudhrejiya, Ashok B. Patel

{"title":"A Study on Pharmaceutical Drug Recall","authors":"Bansi l. Bhalodiya, Amit Kumar J. Vyas, Ajay I. Patel, Ashvin V. Dudhrejiya, Ashok B. Patel","doi":"10.52711/2231-5691.2023.00020","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00020","url":null,"abstract":"The present study describes the pharmaceutical drug recall in different five countries to evaluate the drug recall that occurred in the last three successive years. The different countries have different regulations for drug recall. Drug product recall is an action taken to withdraw or remove a batch or an entire production run of drug product from distribution or use to return them to manufacturer.it is usually done due to deficiency in quality, safety and efficacy. In the USA, guidelines for drugs product recall are described under 21 CFR Parts 7, 107 and 1270. In Australia, guidelines for drugs product recall are described under section 65F of trade practices act 1974. In Canada, it includes under section 25 of Natural Health Products Regulations (NHPR). In India it includes under para 27 and 28 of schedule M. In South Africa SAHPRA (South African Health Products Regulatory Authority) guidelines are responsible for regulations of drug product recall. Majority of drug recalls occur in the United states due to various reasons. In 2020-2022 total 257 drugs were recalled in Last three years. In Canada and Australia 220 and 25 drugs are recalled respectively. India and South Africa have recalled 2 and 21 drugs respectively. By the observation we can conclude that India and South Africa have a smaller number of recalls. In the USFDA number of drug recalls are decreasing due to following up the laws and regulatory.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"9 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83815703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on-Types and Treatment of Alopecia 脱发的类型及治疗综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00025

Poonam C. Rahangdale, Anjali M. Wankhade

{"title":"A Review on-Types and Treatment of Alopecia","authors":"Poonam C. Rahangdale, Anjali M. Wankhade","doi":"10.52711/2231-5691.2023.00025","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00025","url":null,"abstract":"Alopecia is a condition that causes temporary, non-scarring hair loss while maintaining the hair follicle. Alopecia, also known as hair loss, it is a common and upsetting clinical complaint in the primary care setting and can have a variety of aetiologies. The different types of hair loss include well-defined oathces, diffuse hair loss, and total hair loss, which can affect all hair-bearing sites. The most typical type of alopecia is patchy hair loss on the scalp. Hair loss or alopecia affects the majority of the population at some time in their life, and increasingly, sufferers are demanding treatment. There are three primary alopecias (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]). Alopecia areata, tinea capitis, androgenetic alopecia, traction alopecia, trichotillomania, abnormalities in the hair cycle, and congenital alopecia disorders are common causes of alopecia in children and adolescents. There are various forms of alopecia, and each requires a unique course of therapy. The review's goal is to examine the various alopecias and how they impact hair growth and appearance. The review starts out by explaining changes in hair structure and physiology that occur during life. The paper also examines potential future treatments for alopecia, as suggested by recent findings and advancements in technology.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81436540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation Development and Evaluation Nefidipine Loaded Ethosomal Gel for Transdermal Drug Delivery 经皮给药奈非地平溶体凝胶的配方开发与评价

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00015

Y. Sirisha, Buddarthi Sriram, R. Sri. S

引用次数: 0

Corona: Preventive Measures 冠状病毒:预防措施

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00021

D. Sunitha, M. Sudhakar

引用次数: 0