Asian Journal of Pharmaceutical Research最新文献_第3页

A Short Review on Euphorbia neriifolia 大戟属植物综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00022

Priyanka. V. Pawar, Maaz A. Shaikh, Trupti P. Sali, Lalit N. Salunke, Devyani V. Salunke, Neha Jayswal

引用次数: 0

A new challenge the Zygomycosis an invasive life-threatening disease 接合菌病是一种侵袭性威胁生命的疾病

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00024

Manjusha S. Kareppa, Priti B. Savant, Shachi V. Ratnaparkhi, Sohel S. Shaikh, Mohini B. Kadbhane, Someshwar M. Naybal

引用次数: 0

A Review on Eulophia nuda Immunomodulatory activity in Peritoneal macrophages and an assessment of its in-vivo activity in mice 嗜血球对腹腔巨噬细胞免疫调节活性的研究进展及其在小鼠体内活性的评价

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00023

Komal R. Thakre, V. V. Paithnakar, J. Vyas, A. Wankhade

{"title":"A Review on Eulophia nuda Immunomodulatory activity in Peritoneal macrophages and an assessment of its in-vivo activity in mice","authors":"Komal R. Thakre, V. V. Paithnakar, J. Vyas, A. Wankhade","doi":"10.52711/2231-5691.2023.00023","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00023","url":null,"abstract":"The purpose of this review is to highlight the findings of research on immunomodulatory activity of eulophia nuda tubers. Taxonomically, the genus Eulophia and the genus Dioscorea are represented in Amarkand. Pharmacologically, this plant has cytotoxic, antioxidant, antiglycation, and DNA protective activities. The selection of papers was made using the most relevant databases for the pharmacological activity on the basis of their phytochemical constituents. The review also goes over different in-vitro assay techniques and animal study conformation. The effect of Eulophia nuda extracts on the release of mediators such as nitric oxide (NO), superoxide, lysosomal enzyme, and myeloperoxidase activity of isolated murine peritoneal macrophages was studied at different doses. Eulophia nuda extracts were tested biochemically, hematologically, serologically, and histopathologically. The effect of eulophia nuda extracts on delayed-type hypersensitivity (DTH), serum antibody response, and cyclophosphamide-induced myelosuppression in Swiss albino mice was studied. The current work reviews the histopathological, biological, and statistical analysis of eulophia nuda extract on animal models.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83704131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Antifungal Therapy in Treating different Types of Fungal Infections and it’s Future: A Systematic Review 抗真菌治疗在不同类型真菌感染中的作用及其前景:系统综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00026

Amitder Nath Chatterjee

{"title":"Role of Antifungal Therapy in Treating different Types of Fungal Infections and it’s Future: A Systematic Review","authors":"Amitder Nath Chatterjee","doi":"10.52711/2231-5691.2023.00026","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00026","url":null,"abstract":"An estimated 20-25 percent of the world's population has a fungal infection, which is most commonly a Trichophyton type of infection, making fungal disease infection one of the most common types of infection worldwide. Due to drug resistance and changes in the morphology of the fungi, treating fungal infections in humans is one of the most difficult cases to cure. Since 1960, the discovery of systemic antifungal chemotherapy has made a substantial contribution to the treatment of the majority of human fungal infections. Antifungal agents' chemotherapy rely completely on their ability to disrupt the integrity of the plasma membrane, cell wall, cell metabolism, mitotic activity, or inhibit fungal cell formation. Topically (to treat local infections) or systemically (to heal skin infections) antifungal treatments are available (systemic infections treatment). Structure, solubility, mode of action, pharmacokinetics, activity spectrum, therapeutic impact (fungicidal or fungistatic), and toxicity are all characteristics of antifungal medicines. The emerging of multi-drug-resistant fungal diseases has given rise to a new class of fungal infections. The availability of medications that target fungal cells rather than human cells further restricts pharmaceutical options for treating fungal infections. A brief systematic overview of the types of fungal infections, characteristics of antifungal medicines, and the future of antifungal therapy has been clearly stated in the current review so that it can be utilised in further upcoming study.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82359415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse Phase High Performance Liquid Chromatography Method for Simultaneous Estimation of Aspirin and Caffeine in Pure and Tablet 反相高效液相色谱法同时测定阿司匹林纯品和片剂中咖啡因的含量

Asian Journal of Pharmaceutical Research Pub Date : 2023-06-03 DOI: 10.52711/2231-5691.2023.00016

B. Sudhakar, Palaparthi Srivalli, R. Sri. S

{"title":"Reverse Phase High Performance Liquid Chromatography Method for Simultaneous Estimation of Aspirin and Caffeine in Pure and Tablet","authors":"B. Sudhakar, Palaparthi Srivalli, R. Sri. S","doi":"10.52711/2231-5691.2023.00016","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00016","url":null,"abstract":"A new, simple, rapid, accurate and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Aspirin and Caffeine, in Active Pharmaceutical Ingredient form as well as in combined tablet dosage form. Chromatography was carried out on Symmetry ODS C18 (4.6mm × 250mm, 5µm) column using a mixture of Methanol: Acetonitrile (35:65v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 273nm. The retention time of the Aspirin and Caffeine, was 2.085, 5.262±0.02min respectively. The method produces linear responses in the concentration range of 30-70mg/ml of Aspirin and 6-14mg/ml of Caffeine. The mean % assay of marketed formulation was found to be 100.04%, and % recovery was observed in the range of 98-102%. Relative standard deviation for the precision study was found <2%. The developed method is simple, precise and rapid, making it suitable for estimation of Aspirin and Caffeinein API and combined tablet dosage form. The method is useful in the quality control of bulk and pharmaceutical formulations.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81439461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Henna 指甲花综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-03-22 DOI: 10.52711/2231-5691.2023.00009

Snehal D. Kothavale, Asha K. Patil, Roshani P. Kumbhar, S. K. Mohite

引用次数: 0

In vivo Analgesics and in vitro Antioxidants Activity of Newly Synthesized Mannich Bases of Lawsone 新合成的罗氏酮曼尼希碱的体内镇痛及体外抗氧化活性

Asian Journal of Pharmaceutical Research Pub Date : 2023-03-22 DOI: 10.52711/2231-5691.2023.00002

Gulam Muheyuddeen, Sarwar Husain Rayini, P. Yadav, Sujeet Kumar Gupta

{"title":"In vivo Analgesics and in vitro Antioxidants Activity of Newly Synthesized Mannich Bases of Lawsone","authors":"Gulam Muheyuddeen, Sarwar Husain Rayini, P. Yadav, Sujeet Kumar Gupta","doi":"10.52711/2231-5691.2023.00002","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00002","url":null,"abstract":"1, 4- naphthoquinone (Lawsone) is widely distributed in nature and has been used since ancient times in traditional medicine. Lawsone has been used as a dye, and both its natural form and synthetic derivatives exhibit antifungal, antibacterial, antitumor, Antimalarial, molluscicidal, and antioxidant activity. 1, 4- naphthoquinone (Lawsone) was isolated from the leaves of Lawsonia inermis by using the pH gradient (agitation) and maceration method. A convenient synthesis of 2-substituted amino naphthalene-1, 4-dione (3a-o) has been achieved by reaction of isolated 1, 4- naphthoquinone with substituted aniline in the presence of ethanol and DPPH model is used for the evaluation of the antioxidant activities and in vivo analgesic activity using albino mice morphine-induced hot plate method. The structure of the ultimate analogs has been inveterate on the basis of elemental analysis, IR, 1H NMR, and mass spectra. All the standards of elemental investigation, IR, 1H NMR, and mass spectra were initiate to be prominent. The results indicate that synthesized compound 3d having IC50 75.39 ± 4.12mg/ml showed potent antioxidant activity comparable to standard ascorbic acid (IC50 45.54 ± 3.06mg/ml). 3c, 3m, and 3o showed potent analgesic activity comparable to standard nimesulide (100% at 50mg/kg b.w). This reading suggests that leaves of Lawsonia inermis have bioactive compounds for innovative antioxidant and analgesic remedy development.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87822267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calotropis gigantea: A brief Study on Phytochemical and Pharmacological Profile 巨茶甘油三酯:植物化学和药理研究简介

Asian Journal of Pharmaceutical Research Pub Date : 2023-03-22 DOI: 10.52711/2231-5691.2023.00006

Subhajit Mandal

{"title":"Calotropis gigantea: A brief Study on Phytochemical and Pharmacological Profile","authors":"Subhajit Mandal","doi":"10.52711/2231-5691.2023.00006","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00006","url":null,"abstract":"Medicinal plant is used from the ancient times as the major sources of drugs. The main fact is that, we can obtain various life-saving drugs are present, either directly in the extract form or in the modified synthetic form. Calotropis gigantea is a large shrub, gregarious, much branched and young branches covered with white, cottony hairs, contains milky latex. It is a native of India, Malaysia and China and distributed in almost all over the world, which is commonly known as “milkweed”. It is also used in Unani, Ayurveda and siddha system of medicine for many years. The hole part of this plant like flowers, leaves, bark, latex and roots are used as potential remedy for the treatment of a range of ailments. A wide range of isolated compound like alkaloids, tannins, resins, flavonoids, terpenoids, cardiac glycosides and some chemical compound giganteol, α and β calotropeol, β-amyrin, giganteol and isogiganteol etc. are present in this medicinal plant. Beside these chemical compound, C. gigantea also contains some pharmacological activity: anti-asthmatic, antioxidant, antibacterial, antiviral, wound healing, anti-inflammatory, anti-diarrhoeal, hepatoprotective and hypoglycemic, etc.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87271424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Review on Vitamin C- An Excellent Drug Having a Great Scavenging Property 维生素C——一种具有强大清除能力的优秀药物的最新综述

Asian Journal of Pharmaceutical Research Pub Date : 2023-03-22 DOI: 10.52711/2231-5691.2023.00004

Rahul Jodh, M. Tawar, Gaurav Mude, Apurva Fasate, Renuka Sutane, Purvaja Patanray

{"title":"An Updated Review on Vitamin C- An Excellent Drug Having a Great Scavenging Property","authors":"Rahul Jodh, M. Tawar, Gaurav Mude, Apurva Fasate, Renuka Sutane, Purvaja Patanray","doi":"10.52711/2231-5691.2023.00004","DOIUrl":"https://doi.org/10.52711/2231-5691.2023.00004","url":null,"abstract":"Ascorbic acid, also called Vitamin C, is an antioxidant molecule present in both animals as well as in plants. It acts as a redox buffer, reducing reactive oxygen species and neutralising them. It's a cofactor for enzymes that control photosynthesis, hormone manufacturing, and the regeneration of other cells. Antioxidants control cell division and growth, participate in signal transduction, and have a function in a variety of physiological processes, including immunological activation. Collagen manufacture, hormones, neurotransmitters, and iron absorption are all important. Vit C deficiency leads to scurvy and its low concentration raises susceptibility to infections, loosening of teeth, dry mouth, as well as eyes, loss of hair, itching of skin, and so on. Insomnia and weariness Vitamin C, on the other hand, can serve as a pro-oxidant, especially in the skin. The transition metals, such as copper, iron, etc., trigger a variety of dangerous radical reactions. Vit C is a powerful, effective, low-cost antioxidant and is used as a radical booster at the same time. Additional research is required to explain the dual role of vitamin C.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74578088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bempedoic acid a novel drug used for the treatment of Hyperlipidaemia: A Review 治疗高脂血症的新型药物苯戊酸的研究进展

Asian Journal of Pharmaceutical Research Pub Date : 2023-03-22 DOI: 10.52711/2231-5691.2023.00013

Rahul D. Shimpi, Shashikant D. Barhate, Mayur S. Jain

引用次数: 0