Bempedoic acid a novel drug used for the treatment of Hyperlipidaemia: A Review

Abstract

Hyperlipidemia is characterized by elevated levels of lipids that can be caused by a variety of genetic or acquired disorders. In adults, hyperlipidemia has been shown to be a major risk factor in developing CVD. Currently statins, Bile Acid Sequestrants (Resins), Cholesterol Absorption Inhibitors, Fibric Acids, Nicotinic Acid, Omega-3 Fatty Acids are used for the treatment of hyperlipidemia. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the first-line drugs for the treatment of hyperlipidemia by helping to decrease LDL-C and TG levels and increase HDL-C levels in familial and severe hypercholesterolemia. Statins were found to be associated with muscular adverse effects cover a wide range of symptoms, including asymptomatic increase of creatine kinase serum activity and life-threatening rhabdomyolysis Bempedoic acid is a novel lipid-lowering drug with a unique mechanism of action. This article includes a brief review for the Bempedoic acid used in the treatment of hyperlipidaemia.