壳聚糖纳米颗粒研究进展

Aamir Nazir, Neha Kumari, Nitan Bharti Gupta, Rajesh Gupta, Ashima Chandel, Abi C. Varghese
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引用次数: 0

摘要

本研究的重点是概述壳聚糖纳米颗粒在不同非肠外应用的概况,并进一步将重点放在流动研究上,包括支持递送和粘接壳聚糖测量结构。壳聚糖是一种可生物降解的、生物相容性的聚合物,被认为是安全的人类饮食使用和认可的伤口敷料应用。壳聚糖已被用作高分子纳米颗粒的转运体,用于药物在不同组织过程中的转运。壳聚糖具有合成有用的聚集体,可以调整以实现明确的目标,使其成为具有巨大预期应用范围的聚合物。用壳聚糖和壳聚糖衍生物制备的纳米颗粒(NP)通常具有正的表面电荷和黏附性能,可以紧紧附着在体液膜上,并以支持的方式递送药物有效载荷。壳聚糖基NP在治疗恶性肿瘤、胃肠道疾病、呼吸道疾病、精神药物输送和视觉污染等非肠外药物输送方面有不同的应用。壳聚糖在体外和部分体内模型均显示出较低的毒性。本研究对壳聚糖为基础的NP在非肠外给药、壳聚糖性质、调节、毒性、药代动力学和临床前检查方面的研究进展进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advances on Chitosan Nanoparticles
The focal point of this survey is to give an outline of the chitosan based nanoparticles for different non-parenteral applications and furthermore to put a focus on flow research including supported delivery and mucoadhesive chitosan measurement structures. Chitosan is a biodegradable, biocompatible polymer viewed as safe for human dietary use and endorsed for wound dressing applications. Chitosan has been utilized as a transporter in polymeric nanoparticles for drug conveyance through different courses of organization. Chitosan has synthetic useful gatherings that can be adjusted to accomplish explicit objectives, making it a polymer with an enormous scope of expected applications. Nanoparticles (NP) ready with chitosan and chitosan subsidiaries ordinarily have a positive surface charge and mucoadhesive properties to such an extent that can hold fast to bodily fluid films and delivery the medication payload in a supported delivery way. Chitosan-based NP have different applications in non-parenteral medication conveyance for the therapy of malignant growth, gastrointestinal illnesses, aspiratory sicknesses, drug conveyance to the mind and visual contaminations which will be exemplified in this survey. Chitosan shows low poisonousness both in vitro and some in vivo models. This survey investigates ongoing exploration on chitosan based NP for non-parenteral medication conveyance, chitosan properties, adjustment, poisonousness, pharmacokinetics and preclinical examinations.
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