卡马唑片剂和散装剂型的紫外分光光度法研究与验证

Zainab A. Bagalkote, G. Gajeli
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引用次数: 3

摘要

目的:建立一种简便、灵敏、精确、重现性好的紫外可见分光光度法测定卡咪唑片剂型的方法。方法:Carbimazole在甲醇和蒸馏水(30:70)中的紫外光谱在289.6nm处显示λ max。Beer定律在10-50µg/ml的浓度范围内有效。该方法具有良好的线性度、准确度、精密度、稳健性和可靠性。结果:该方法在10 ~ 50µg/ml范围内具有良好的线性关系,回归方程为y = 0.0232x + 0.0466,回归系数r2= 0.9992,检出限为1.818µg/ml,检出限为5.509µg/ml。结论:本法可用于卡咪唑片剂的含量测定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
UV Spectrophotometric Method Development and Validation of Carbimazole in Bulk and Tablet Dosage form
Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the estimation of Carbimazole in Tablet dosage form. Methods: The UV spectrum of Carbimazole in methanol and distilled water (30:70) showed λ max at 289.6nm. Beer’s law is valid in the concentration range of 10-50µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 10-50µg/ml with the regression equation y = 0.0232x + 0.0466, and regression coefficient i.e, r2= 0.9992 moreover, the method was found to be highly sensitive with LOD (1.818µg/ml) and LOQ (5.509µg/ml). Conclusion: From the results it can be concluded that the given method can be successfully applied for assay of Carbimazole in Tablet dosage form.
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