Asian Journal of Pharmaceutical Research最新文献

{"title":"Ethosomes: A carrier for Transdermal Drug Delivery System","authors":"Muskan M. Maniyar, Amol S. Deshmukh, Suvarna J. Shelke","doi":"10.52711/2231-5691.2022.00037","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00037","url":null,"abstract":"In our five sense organs skin is the biggest organ which prevents entry of different foreign particles into the systemic circulation. For our body drug is also considered as a foreign particle hence it is difficult task to reach the drug into systemic circulation through the transdermal route without invasion. Now a day’s many novel formulations are present in the market which allows the transfer of drug through the transdermal route without invasion like liposomes, phytosomes, neosomes and ethosomes. But with the help of ethosome formulation it becomes very easy to transfer the drug into systemic circulation through the transdermal route. Large drug molecules can be delivered to site of action by ethosomes. Ethosomes are the bilayer lipid vesicles which allow the transfer of drug into the deep skin layers and into the blood. It contains large amount of ethanol and penetration enhancers are incorporated into it to enhance the rate of penetration. It contains the phospholipid bilayer with polar head and nonpolar tail. At the center ethanolic cavity is present which is filled with the hydroethanolic solution. We can incorporate all types of drug into the ethosome i.e., lipophilic, hydrophilic, and amphiphilic and this property makes it unique from other dosage forms. Further we can formulate cream, gel or patches of ethosomes. Cellutight EF, Nanominox, Noicellex, Supravir cream these are some examples of marketed ethosomal formulations. This review summarizes the types of ethosomes i.e., classical ethosomes, binary ethosomes and transethosomes. And also includes advantages, disadvantages, therapeutic applications, methods of preparation and characterization of the ethosomes.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74304451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review Article on Formulation and Evaluation of Polyherbal Antidandruf Powder Shampoos","authors":"Sonawane Chaitanya J., N. Jaiswal","doi":"10.52711/2231-5691.2022.00035","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00035","url":null,"abstract":"The objective of this study is to communicate and evaluate polyhedral shampoo for cosmetic purpose from herbal elements. Dandruff is a public condition affecting the scalp disorder affected by yeast Pittosporum. Dandruff cannot be totally removed but can only be achieved and professionally controlled. Shampoo is a haircare creation used for the eradication of oils, dirt, skin elements, dandruff, ecological contaminants and other pollutant elements that slowly build up in hair. Herbal anti-dandruff shampoos were framed using herbal based elements like Lemon Grass Oil, Neem oil, Henna, Aloe Vera gel and other elements for formulating base shampoo. ment with least side effects has been recognized that ayurvedic preparation is to be auspicious for cosmetic usage too. In the situation of altering food habits, stress level and dependent stratosphere situations, amount of skin and hair diseases are come upon. Preservation of other issue shall not satisfy the indispensable so superfluous management is important that to which is safe. In circumstance of hair syndromes like dandruff problem, appropriate collection of herbal fundamental with their indispensable numbers, dose procedure can be prepared as precipitate shampoo to battle against dandruff this study is focus to formulate a entirely accepted shampoo and its comparative calculation with promoted products. Ingredients and Methods: In contemporary work the research and valuation of the shampoo of lawsonia interims, calendula officinalis Linn, citrus limnonym, citrus ulgaric and santolina trifoliatus, leaf extract and supplementary with two marketed bathes. The extract was absorbed under reduced pressure and weighed for determination of vintage. Withdrawal was completed in selected herbs by different extraction technique.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77546851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Prophylactic Regimen by Evaluation of Asymptomatic SARS CoV-II Carriers","authors":"Ashwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. Patel","doi":"10.52711/2231-5691.2022.00036","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00036","url":null,"abstract":"The coronavirus disease 19(COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-II), which emerged in Wuhan, China and spread around the world. It is considered a relative of Severe Acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), The cause of COVID-19 is a beta coronavirus named SARS-CoV-2 that affects the lower respiratory tract and manifests as pneumonia in humans. The Asymptomatic carriers have become the current focus of global epidemic prevention and control efforts. These carriers of the virus display no clinical symptoms but are known to be contagious. As \"silent spreaders\", asymptomatic carriers warrant attention as a part of disease prevention and control. The comparable viral load in a group of asymptomatic carriers of COVID-19 was found to be higher than that of the symptomatic carriers. There are numerous micronutrients which are essential for immunocompetence, particularly Vitamin A, C, D, E, B, iron, selenium, and zinc. Immunonutrition refers to the modulation of the immune system through the modification of dietary nutrients. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. The present review provides a brief information on supplementation of Immunonutrients in form of vitamins which ultimately can act as prophylactic regimen for Asymptomatic carriers of SARS CoV-II virus.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89870055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Microsponges a Novel Drug Delivery System","authors":"S. Mankar, Mahale Gayatri","doi":"10.52711/2231-5691.2022.00040","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00040","url":null,"abstract":"Bottom of Form Microparticulate drug delivery systems have shown a good interest within the pharmaceutical space. they permit the rise of drug therapeutic effectiveness and therefore the reduction of aspect effects. during this context, microsponges represent a brand new model of porous uu microspheres, which permit the defense of a good vary of active agents. Microsponge drug delivery system (MDS) was developed to deliver the pharmaceutical ingredients efficiently at the positioning of administration at a restricted dose. MDS is predicated on pore size of sponges. The action of microsponges lasts up to 12 hours. A microsponge's delivery system could be a extremely cross-linked, porous, chemical compound microsphere, chemical compound system consisting of porous microspheres that may entrap and unleash them into the skin over long amount. This delivery system provides extended release with reduced irritation, higher tolerance, improved thermal, physical and chemical stability. Microsponges area unit ready by many technique utilization emulsion system or by suspension chemical process into a liquid-liquid system. Microsponges will entrapped numerous style of drug and incorporated in formulation like cream, powder, gels, and lotions. Topical preparation have some disadvantages like unpleasant odour, oiliness and skin irritation and fail to achieve the circulation this drawback is overcome by microsponges delivery system.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81263105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Monitoring of Cardiovascular Biomarkers using Artificial Intelligence (AI)","authors":"S. Mahajan, Heemani Dave, S. Bothe, Debarshikar Mahpatra, S. Sonawane, S. Kshirsagar, S. Chhajed","doi":"10.52711/2231-5691.2022.00038","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00038","url":null,"abstract":"Different CVDs (CVD) are the leading wreak of mortality and disability worldwide. The pathology of CVD is complex; multiple biological pathways have been involved. Biomarkers act as a measure of usual or pathogenic biological processes. They play a significant part in the definition, prognostication, and decision-making with respect to the treatment of cardiovascular events. Inthis article, we had summarized key biomarkers which are essential to predict CVDs. We had studied prevalence, pattern of expression of biomarkers (salivary, inflammatory, oxidative stress, chemokines, antioxidants, genetic, etc.), its measurable impact, benefits of early detection and its scope. A considerable number of deaths due to cardiovascular diseases (CVDs) can be attributed to tobacco smoking and it rises the precarious of deathfrom coronary heart disease and cerebrovascular diseases. Cytokines which is categorized into pro inflammatory and anti-inflammatory take part in as biomarkers in CHD, MI, HF. Troponin, growth differentiation factor-15(GDF-15), C-reactive protein, fibrinogen, uric acid diagnose MI and CAD. Matrix Metalloproteins, Cell Adhesion Molecules, Myeloperoxidase, Oxidative stress biomarkers, Incendiary biomarkers are useful to predict the risk of UA, MI, and HF. Increased Endothelin-1, Natriuretic peptides, copeptin, ST-2, Galectin-3, mid-regional-pro-adrenomedullin, catecholamines are used to prognosticate Heart failure. Modern technologies like Artificial Intelligence (AI), Biosensor and high-speed data communication made it possible to collect the high-resolution data in real time. The high-resolution data can be analyzed with advance Machine Learning (ML) algorithms, it will not only help to discover the disease patterns but also an real-time and objective monitoring of bio-signals can help to discover the unknown patterns linked with CVD.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80300218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal elicited Hepatoprotection and Hepatotoxicity – A Comprehensive Review","authors":"Amana Parveen, Anju Singh, R. A., Sagar Singh Jough, Shivam Kumar Verma","doi":"10.52711/2231-5691.2022.00024","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00024","url":null,"abstract":"Liver maladies are a significant overall medical issue, with high endemicity in creating nations. They are chiefly brought about by synthetic substances and a few medications when taken in exceptionally high portions. Not with standing propels in present day medication, there is no successful medication accessible that animates liver capacity, offer insurance to the liver from harm or help to recover hepatic cells. There is pressing need, consequently, for powerful medications to supplant/supplement those in current use. The plant realm is without a doubt important as a wellspring of new therapeutic operators. The current work comprises an audit of the writing on plant separates and artificially characterized particles of common beginning with hepatoprotective action. The survey shows various plants, their families, topographical dissemination, plant parts used, kind of test and hepatoprotective action such as A. paniculata and some various species etc. It additionally incorporates 58 mixes confined from higher plants, characterized into proper substance gatherings. This work expects to help scientists in the investigation of regular items helpful in the treatment of liver sicknesses.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77868493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of Communication and relation between Pharmacist and patient","authors":"Manohar D. Kengar, Amol A. Patil, Hrithik S. Ankush, Sayali P. Pawar, Vaishnavi V. Bhagat","doi":"10.52711/2231-5691.2022.00028","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00028","url":null,"abstract":"Communicating with variety of patients will primary concern in healthcare today. The way of communication in which the doctors, Patients, Physicians or therapist convey the massage regarding the care, relation between patient and pharmacist affected by the different factor which include the patient’s healthcare literacy, the amount of information provided clear vision how much the individuals listen to each other, and tone of voice. In daily routine the contact and communication in between the different types of patients, in this basically the important way that is better communication is achieve better patients compliance, also they identify the problems related to the patient by reviewing prescription, case, notes, records and initial consultation with pharmacist for best effective communication there will various steps in that personal call to the patient, consultation to the pharmacist about the medication and therapy.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85673642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Bedaquiline among Drug Resistant-Tuberculosis patients","authors":"Mohammed Musa Saaduddin, S. G, D. Dhanalakshmi","doi":"10.52711/2231-5691.2022.00020","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00020","url":null,"abstract":"Background: India has one of the highest burdens of drug-resistant tuberculosis (DR-TB) globally. The persistent spread of DR-TB is one of the most daunting problems the world is witnessing. Current regimens for DR-TB are complicated, lengthy, and expensive compared to those used to treat drug-susceptible TB, leaving patients with much less effective treatment options. Bedaquiline (BDQ) is a novel drug that has strong bactericidal and sterilizing activities against Mycobacterium tuberculosis. The WHO recommends BDQ for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). The objective of the study is to evaluate the utilization of BDQ among drug-resistant tuberculosis patients in a tertiary care hospital. Materials and Methods: A hospital-based retrospective observational study was conducted at the Government General and Chest Hospital in Erragadda, Hyderabad, Telangana, where suspected Tuberculosis cases are referred. All patients who were prescribed bedaquiline regimen were included in the study. Results: 23 Patients were prescribed BDQ during the study duration. The mean age of the patients was 41± 14.24 years and most of them were in the age group of 21-40 years. 15 patients (65.21%) were Males. Diabetes mellitus was the most common co-morbid condition. Two patients (8.70%) successfully completed the treatment, 3 patients (13.04%) died during treatment and 18 patients (78.26%) were still receiving the treatment during the study period. Adverse effects were documented in 12 patients and the most common adverse events were related to gastrointestinal tract. Conclusion: Bedaquiline containing regimen was well tolerated with less number of manageable adverse effects.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86206370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on New Herbal Remedies for treatment of Mouth Ulcer","authors":"Rina G. Maskare, Ayush P. Agrawal, Mayuri S. Pal, Jidnyasa R. Yerne, Megham Chaudhri, Anup R. Bawankar, Gaytri B. Sonkusre","doi":"10.52711/2231-5691.2022.00025","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00025","url":null,"abstract":"Mouth ulcer is one of the common disorders caused due to variety of etiological factors. The two most common causes of oral ulceration are local trauma (e.g. rubbing from a sharp edge on a filling) and aphthous stomatitis (\"canker sores\"), a condition characterized by recurrent formation of oral ulcers for largely unknown reasons. Mouth ulcers often cause pain and discomfort, and may alter the person's choice of food while healing occurs. This review focusses on various herbal remedies for the treatment of mouth ulcer. Lozenges are solid preparations that contain one or more medicaments, usually in a flavoured, sweetened base, and are intended to dissolve or disintegrate slowly in the mouth or these are medicated candy intended to be dissolved slowly in the mouth to lubricate and sooth the irritated tissues of throat. Lozenges are one of the widely used dosage forms. The benefits of the medicated lozenges are they increase the retention time of the dosage form in oral cavity which increases bioavailability, reduces gastric irritation and bypasses first pass metabolism. Lozenges provide a palatable means of dosage form administration and enjoy its position in pharmaceutical market owing to its several advantages but it suffers from certain disadvantages too. This dosage form can be adopted for local as well as systemic therapy and a wide range of active ingredient can be incorporated in them lozenges or troches are experiencing a renewed popularity as a means of delivering many different drug products. Lozenges have various advantages and disadvantages. Different types of lozenges and their methods of preparation along with ingredients used in their preparation are discussed. Drug candidates which can be incorporated in lozenges include antiseptics, local aesthetics, antibiotics, antihistamines, antitussives, analgesics, decongestants and demulcents. The selection criteria for flavouring agents are mentioned, quality control tests of lozenges have been reviewed. The present review covers more or less all aspects associated with lozenges and also throws light on the development criteria of the lozenges dosage form.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74097165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Development and Evaluation of Thiocolchicoside and Famotidine Agglomerates by Crystallo Co-Agglomeration Technique","authors":"S. Bhamburkar, S. Patharkar","doi":"10.52711/2231-5691.2022.00019","DOIUrl":"https://doi.org/10.52711/2231-5691.2022.00019","url":null,"abstract":"Thiocolchicoside and Famotidine are both have known to be used in joint pain or in the treatment of rheumatoid arthritis, etc. But the problem arises in the bioavailability and absorption of these drugs in the body. The current study deals with the design and evaluation of crystal co-agglomerates prepared with the use of various concentration of polymers like HPMC K15M and PVA. The aim of the study was to improvise the flow property, wettability, and dissolution property of the drug and to enhance its absorption in the body which will give better therapeutic response. The prepared co-agglomerates were evaluated for the parameters and it was found that the F4 bath was optimum because better flow ability, maximum drug content and increased dissolution property. SEM study shows the clear cylindrical crystals formed and the stability study shows that the prepared co-agglomerates were stable for the period of time without any significant change in the preparation. It was concluded that the preparation of crystal co-agglomerates was a successful approach in improving the various properties which can reduce the chances of metabolism of drug and will give better therapeutic response and stability of the drug.","PeriodicalId":8537,"journal":{"name":"Asian Journal of Pharmaceutical Research","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89815762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}