A Review on New Herbal Remedies for treatment of Mouth Ulcer

Abstract

Mouth ulcer is one of the common disorders caused due to variety of etiological factors. The two most common causes of oral ulceration are local trauma (e.g. rubbing from a sharp edge on a filling) and aphthous stomatitis ("canker sores"), a condition characterized by recurrent formation of oral ulcers for largely unknown reasons. Mouth ulcers often cause pain and discomfort, and may alter the person's choice of food while healing occurs. This review focusses on various herbal remedies for the treatment of mouth ulcer. Lozenges are solid preparations that contain one or more medicaments, usually in a flavoured, sweetened base, and are intended to dissolve or disintegrate slowly in the mouth or these are medicated candy intended to be dissolved slowly in the mouth to lubricate and sooth the irritated tissues of throat. Lozenges are one of the widely used dosage forms. The benefits of the medicated lozenges are they increase the retention time of the dosage form in oral cavity which increases bioavailability, reduces gastric irritation and bypasses first pass metabolism. Lozenges provide a palatable means of dosage form administration and enjoy its position in pharmaceutical market owing to its several advantages but it suffers from certain disadvantages too. This dosage form can be adopted for local as well as systemic therapy and a wide range of active ingredient can be incorporated in them lozenges or troches are experiencing a renewed popularity as a means of delivering many different drug products. Lozenges have various advantages and disadvantages. Different types of lozenges and their methods of preparation along with ingredients used in their preparation are discussed. Drug candidates which can be incorporated in lozenges include antiseptics, local aesthetics, antibiotics, antihistamines, antitussives, analgesics, decongestants and demulcents. The selection criteria for flavouring agents are mentioned, quality control tests of lozenges have been reviewed. The present review covers more or less all aspects associated with lozenges and also throws light on the development criteria of the lozenges dosage form.