Microwave Generated Bionanocomposites for Solubility and Dissolution Enhancement of Poorly Water Soluble Drug

Abstract

Drugs that shows complete oral absorption and good bioavailability are soluble in gastrointestinal tract or vice versa. Objective and Method: To enhance the solubility and dissolution of poorly water soluble drug itraconazole. Technique used- Microwave generated bionanocomposites technique. Carriers- Chitosan, β- cyclodextrin and Poly vinyl pyrolidine. Result and Conclusion: The prepared bionanocomposites was evaluated by UV spectroscopy, XRD study, In vitro drug release study and TEM. The results shows that in vitro data obtained for bionanocomposites of itraconazole showed increase solubility in phosphate buffer having pH= 6.8 and the method of preparation of itraconazole found to be simple, reproducible, provide good solubility and drug content. Also it is obtained that there was maximum 23 fold increase in solubility when Poly vinyl pyrolidine used as a carrier in 1:4 and hence considered as effective carrier for crystallization of itraconazole.