Asian Biomedicine最新文献

{"title":"Copy number variations of cytochrome <i>P450</i> genes in Kinh Vietnamese.","authors":"Nhung Phuong Vu,&nbsp;Ton Dang Nguyen,&nbsp;Binh Huy Nguyen,&nbsp;Duong Thuy Nguyen,&nbsp;Hai Van Nong,&nbsp;Ha Hai Nguyen","doi":"10.2478/abm-2023-0048","DOIUrl":"https://doi.org/10.2478/abm-2023-0048","url":null,"abstract":"<p><strong>Background: </strong>The cytochrome P450 (<i>CYP450</i>) family is well known as a major group of drug metabolizing enzymes. The polymorphism of <i>CYP450</i> genes is the main factor having an impact on the interindividual difference in drug response, including drug efficacy and drug safety. The single nucleotide polymorphism (SNPs) of Vietnamese Kinh has been widely studied, but information about the copy number variations (CNVs) of other <i>CYP450</i> genes is still unknown.</p><p><strong>Objective: </strong>To identify the CNV variability of <i>CYP450</i> in 154 healthy unrelated Kinh Vietnamese, except e<i>CYP2D6</i>, which was previously reported.</p><p><strong>Methods: </strong>Multiplex Ligation-Dependent Probe Amplification (MLPA) was applied for determination of copy number of 10 <i>CYP450</i> genes. Later, PCR or quantitative PCR (qPCR) was used to confirm the detected CNVs in randomly chosen subjects.</p><p><strong>Results: </strong>Of the 154 subjects, along with <i>CYP2D6</i>, 4 other <i>CYP450</i> genes showed CNVs including duplications (<i>CYP1B1</i>), deletions (<i>CYP2A6</i> and <i>CYP2C9</i>), and both duplications and deletions (<i>CYP2E1</i>). Among these, <i>CYP2A6</i> exhibited the greatest frequency of CNVs compared with other <i>CYP450</i>, in which <i>CYP2A6</i>Del accounted for 11%. Meanwhile, allele <i>CYP2E1</i>Del showed the lowest frequency with only 0.3%.</p><p><strong>Conclusions: </strong>The present study provides new insight into <i>CYP450</i> CNVs in the Kinh Vietnamese cohort. Our data have contributed to genetic profiling of <i>CYP450</i> CNVs in Vietnam, which would be helpful for facilitating implementation of pharmacogenetics in drug dosing adjustment in Vietnam.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10306690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidic environment could modulate the interferon-γ expression: Implication on modulation of cancer and immune cells' interactions.","authors":"Vishal Sharma,&nbsp;Jagdeep Kaur","doi":"10.2478/abm-2023-0047","DOIUrl":"https://doi.org/10.2478/abm-2023-0047","url":null,"abstract":"<p><strong>Background: </strong>In rapidly growing solid tumors, insufficient vascularization and poor oxygen supply result in an acidic tumor microenvironment, which can alter immune response.</p><p><strong>Objective: </strong>To investigate the role of the acidic microenvironment in immune response modulation along with cancer and immune cells' interactions.</p><p><strong>Method: </strong>To mimic the tumor microenvironment conditions, T cells (Jurkat), macrophages (THP-1), and HeLa (cervical) cells were cultured under acidic conditions (pH 6.9, pH 6.5) and physiological pH (7.4). The HeLa cell culture medium was exploited as a tumor cell conditioned medium. Real-time PCR was carried out to quantify the mRNA levels, while flow cytometry and western blot hybridization was carried out to ascertain the levels of different proteins.</p><p><strong>Results: </strong>The acidic microenvironment around the T cells (Jurkat) and macrophage cells (THP-1) could lead to the downregulation of the interferon gamma (IFN-γ). An increase in IFN-γ expression was observed when Jurkat and macrophage cells were cultured in HeLa cells conditioned medium (HCM) at low pH (pH 6.9, pH 6.5). The HeLa cells under acidic environment (pH 6.9, pH 6.5) upregulated interleukin 18 levels and secreted it as exosome anchored. Additionally, enhanced nuclear localization of NF-κB was observed in Jurkat and THP-1 cells cultured in HCM (pH 6.9, pH 6.5). Jurkat and THP-1 cultured in HCM revealed enhanced cytotoxicity against the HeLa cells upon reverting the pH of the medium from acidic to physiological pH (pH 7.4).</p><p><strong>Conclusion: </strong>Collectively, these results suggest that the acidic microenvironment acted as a key barrier to cancer and immune cells' interactions.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10306692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h.","authors":"Guangfeng Zhao,&nbsp;Xiongjun He,&nbsp;Yajie Liu,&nbsp;Liang Zhang,&nbsp;Kaifeng Li","doi":"10.2478/abm-2023-0046","DOIUrl":"https://doi.org/10.2478/abm-2023-0046","url":null,"abstract":"<p><strong>Background: </strong>Evidence of endovascular treatment (ET) for patients with progressive infarction of the posterior circulation exceeding 24 h is lacking.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of ET for progressive posterior circulation cerebral infarction.</p><p><strong>Methods: </strong>This retrospective study evaluated the ET for 18 patients with posterior circulation infarction caused by vertebrobasilar artery occlusion from July 2017 to November 2018. The conditions of patients worsened despite receiving intravenous thrombolysis or combination therapy with clopidogrel and aspirin. The time from the onset of cerebral infarction to puncture was >24 h. The preoperative National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), and related risk factors of patients at 3 months were analyzed postoperatively.</p><p><strong>Results: </strong>The preoperative NIHSS score was 10.6 (IQR: 6.5), and the time from onset to puncture was 163.5 ± 144.7 h. Postoperative blood flow was modified thrombolysis in cerebral infarction (mTICI) grade 2b or above. During the follow-up period, 1 patient died of basilar artery re-occlusion and pulmonary infection, and 1 died of postoperative hyperperfusion hemorrhage, with a mortality rate of 11.1% (2/18). No recurrent ischemic events were observed in any of the 16 patients during the 3-month follow-up period. The mean mRS score was 1.3 (IQR: 2.3), and 75% patients (12/16) had an mRS score of 0-2. There were no significant differences in age, gender, clinical characteristics, and stroke subtype between patients with mRS scores ≤2 and >2.</p><p><strong>Conclusion: </strong>In patients with progressive posterior circulation cerebral infarction caused by vertebral basilar artery occlusion, ET is effective and safe even if the time from onset to puncture exceeds 24 h.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10306688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous monitoring of trends in pathogen and susceptibility profiles in patients with skin and soft tissue infections (SSTIs).","authors":"","doi":"10.2478/abm-2023-0043","DOIUrl":"https://doi.org/10.2478/abm-2023-0043","url":null,"abstract":"The skin is colonized by a diverse collection of microorganisms. Most microorganisms coexist with their human hosts without any complications. However, in many conditions, such as impaired host immunity and presence of virulent pathogens, skin and soft tissue infections (SSTIs) can occur [1]. The most common organisms associated with SSTIs are bacteria, but other organisms such as fungi, viruses, Mycobacterium tuberculosis, and protozoa may occur [1]. The profile of predominant pathogens may vary based on geographical regions. This is most likely due to evolution of pathogens associated with environmental changes, as well as the volume of antimicrobial use in the areas to control infections in humans and animals. The inappropriate use of antimicrobial agents can cause antimicrobial resistance [2, 3]. The spectrum of clinical manifestations in patients with SSTIs may range from cellulitis, folliculitis, erysipelas, and abscesses, including large furuncles and carbuncles. The clinical spectrum of the SSTIs can range from mild to severe, including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis [4]. Definite diagnosis of pathogens causing SSTIs is necessary for an appropriate choice of antimicrobial regimens. Definite diagnosis will require the isolation of pathogens via cultures of the skin lesions, biopsy with adequate tissues, and blood culture, among others. Isolated pathogens can be identified through specific microbiological analytic techniques such as special stains, molecular techniques, and antigen detection methodologies [1]. Immunocompromised hosts such as patients with immunodeficiencies, HIVs, cancers, and other clinical conditions can pose special diagnostic and therapeutic challenges [1]. Removal of pus and necrotic tissue from the source of infection is needed. The choice of initial treatment depends on the epidemiological trends (communityor hospital-acquired infections), pathogen or pathogens involved, the virulence of pathogens, the seriousness of pathology, the patient’s co-morbidities, as well as the symptoms and signs of systemic toxicity. There is an increasing use of rapid diagnostic tests to help in the selection and de-escalation of antimicrobials for SSTIs [4]. Knowledge of local epidemiology and antimicrobial susceptibility patterns of community and hospital strains, as well as the immunological status of the patients, is important. Immunocompromised patients with signs of systemic toxicity may need broad coverage to prevent poor outcomes. In immunocompetent patients with nonpurulent cellulitis without systemic toxicity and risk for methicillin-resistant Staphylococcus aureus (MRSA), coverage for low-virulence bacteria such as streptococci and methicillin-sensitive S. aureus may be adequate. For most patients with simple skin abscess, oral antibiotic therapy may be sufficient. Immunocompetent patients with purulent cellulitis and signs of possible systemic toxicity or rapid deterioration may requ","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden and control of congenital syphilis: a need for a comprehensive strategy.","authors":"","doi":"10.2478/abm-2023-0037","DOIUrl":"https://doi.org/10.2478/abm-2023-0037","url":null,"abstract":"Syphilis is caused by the spirochete bacterium Treponema pallidum. If inadequately treated during pregnancy, the spirochete can lead to congenital syphilis (CS), which can give rise to subsequent severe sequelae or fetal, neonatal, or infant death [1]. The burden of CS varies. Recent estimates suggest that CS has decreased worldwide between 2012 and 2016 [2]. However, in some countries such as the United States, reported cases of CS have increased since 2012 [2, 3]. CS is acquired through transplacental transmission of spirochetes. Pregnant mothers with untreated primary or secondary syphilis are at the highest risk of transmitting syphilis to the fetus during pregnancy. Vertical transmission of spirochetes to offspring commonly occurs from mothers who are inadequately treated or not treated at all [4]. Since 2007, the World Health Organization has advocated the global elimination of mother-to-child transmission of T. pallidum aiming at controlling CS, which can cause significant severe sequelae and burden to individuals and the society [5]. Manifestations of early CS are varied, and diagnosis in newborn infants is difficult [1]. It is therefore important to recognize CS in infants and young children with unexplained growth problems and biochemical and hematological abnormalities [6]. All infants born to mothers who have reactive nontreponemal and treponemal tests for syphilis during pregnancy, as well as infants and children with clinical findings compatible with CS, should be initially evaluated. These can be done using existing screening tests such as Venereal Disease Research Laboratory (VDRL) test and rapid plasma reagin titer [6]. Direct fluorescent antibody staining, darkfield microscopy, and/or polymerase chain reaction (PCR) of nasal discharge and/or swabs of skin lesions should be performed if available. A diagnosis of CS may be established by the demonstration of serologic reactions typical of syphilis in relation to mother’s serology, the detection of T. pallidum by darkfield microscopy, or PCR of infected body fluids or lesions; the demonstration of T. pallidum is achieved by special stains or histopathologic examination [6–8]. Kulsirichawaroj and Lumbiganon [9] report, in a large study in this volume, that the incidence of CS in a university hospital is high. Factors associated with CS include inadequate screening and treatment of maternal syphilis and preterm birth. They advocate a systematic approach to improvement of antenatal care. This would require efforts toward evidencebased, interprofessional strategies. A collaborative perinatal/ neonatal preventive approach to the care of pregnant women may reduce the current trends of CS in countries worldwide. Strategies prioritizing early identification and treatment of at-risk neonates are necessary to reduce– and eliminate – the devastating long-term consequences of the conditions in vulnerable populations.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the shear wave elastic quantitative measurement of penile tissue in rats.","authors":"Wan-Ting Rao,&nbsp;Jing-Dong Tang,&nbsp;Jin-Fang Xing","doi":"10.2478/abm-2023-0040","DOIUrl":"https://doi.org/10.2478/abm-2023-0040","url":null,"abstract":"<p><strong>Background: </strong>As a new ultrasound technology, 2-dimensional shear wave elastography (2D-SWE) can evaluate the elastic characteristics of penile tissue. However, no studies have reported the main factors affecting the shear wave elastic quantitative measurement (SWQ) in penile tissue.</p><p><strong>Objectives: </strong>To analyze the main factors affecting the SWQ reflecting the elastic characteristics of penile tissue by 2D-SWE.</p><p><strong>Methods: </strong>Twenty healthy male Sprague-Dawley rats (5-60 weeks old) were selected for this study. We performed the 2D-SWE examination on the penis using the Aixplorer ultrasound system, with SWQ as the measurement index. We performed penile immunohistochemistry analysis with the positive area proportion (PAP) of alpha-smooth muscle actin (PAP_S) and type III collagen fiber (PAP_C) as the outcomes. Then, we conducted multiple linear regression analysis to explore the correlation of SWQ with PAP_S and PAP_C and established the regression equation.</p><p><strong>Results: </strong>The multiple linear regression analysis showed that the linear regression equation (SWQ = 10.376 - 0.05 PAP_S - 0.07 PAP_C) was statistically significant (<i>F</i> = 21.153, <i>P</i> < 0.001). The content of smooth muscle cells (SMCs) and collagen fibers was negatively correlated with SWQ, affecting 42.6% of the total variation in SWQ (<i>R</i>² = 0.426).</p><p><strong>Conclusions: </strong>SMCs and collagen fibers are the main factors affecting the SWQ value of penile tissue and the primary tissue components determining the SWQ when using 2D-SWE to quantitatively evaluate the elastic characteristics of penile tissue.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contemporary immunoassays for HIV diagnosis: a concise overview.","authors":"Abdullah,&nbsp;Misbahud Din,&nbsp;Abdul Waris,&nbsp;Muddasir Khan,&nbsp;Sajjad Ali,&nbsp;Riaz Muhammad,&nbsp;Muhammad Salman","doi":"10.2478/abm-2023-0038","DOIUrl":"https://doi.org/10.2478/abm-2023-0038","url":null,"abstract":"Abstract Recent advances in human immunodeficiency virus (HIV) diagnostics have improved the management of disease progression significantly, which have also boosted the efficacy of antiviral therapies. The detection of HIV at the earliest is very important. A highly recognized and effective virological biomarker for acute HIV infections is p24 antigen. This brief overview is based on advances of HIV diagnosis while focusing on the latest HIV testing technologies including HIV-specific antigens detecting assays of both anti-HIV antibodies and p24 antigen. In addition to other emerging molecular diagnostics for acute HIV infection, the utilization of p24 antigen has been summarized. Moreover, it has been explained how these immunoassays have reduced the window period for detection of HIV in the acute stage of infection.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of predictive equations for resting energy expenditure estimation in mechanically ventilated Thai patients.","authors":"Napplika Kongpolprom","doi":"10.2478/abm-2023-0041","DOIUrl":"https://doi.org/10.2478/abm-2023-0041","url":null,"abstract":"<p><strong>Background: </strong>Indirect calorimetry (IC) is the most precise approach for estimating calorie demand in critically ill patients. Despite this, owing to unaffordable devices, it is rarely used in practice. Predictive equations are the alternatives.</p><p><strong>Objectives: </strong>To assess the accuracy of 14 predictive resting energy expenditure(REE) equations in ventilated Thai patients.</p><p><strong>Methods: </strong>We compared the accuracy and agreement of 14 equations. The equations included the American College of Chest Physicians(ACCP) equation, Harris-Benedict equation(HBE), 1.2×HBE, 1.5×HBE, Mifflin-St. Jeor(MSJ), Ireton-Jones 1992 and 2002, Penn State 2003(HBE and MSJ) and 2010, Swinamer 1990, Faisy, Brandi 1999, and 25 kcal/kg equation. An equation was ascertained as accurate if the calculated values fell within ±10% of the measured REEs. Spearman correlation coefficient, Bland-Altman method, and intraclass correlation coefficient were used to analysis.</p><p><strong>Results: </strong>We obtained data from 24 ventilated patients undergoing REE measurement by IC. Fifty percent of them were male with a median age of 64.5 years, a median height of 160 cm, and a median body mass index of 22.95 kg/m². The predictive precision of all equations was poor, with largely different accuracies from 6.7% to 48.1%. The most reliable equation was Penn State 2010. The ACCP, HBE, MSJ, and Penn State 2003(HBE) tended to underestimate calorie need. Contrastingly, the other equations tended to overestimate REEs. Despite a moderate degree of correlations, the Bland-Altman plots demonstrated clinically unacceptable discrepancies between measured REE and REE calculated by each equation.</p><p><strong>Conclusions: </strong>In ventilated Thai patients, there were no precise equations for determining REE.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of diphenhydramine intoxication showing prolonged false positive tricyclic antidepressant in the urine assay.","authors":"Dongsun Kim,&nbsp;Hyun Young Shin,&nbsp;Bon D Ku","doi":"10.2478/abm-2023-0042","DOIUrl":"https://doi.org/10.2478/abm-2023-0042","url":null,"abstract":"<p><strong>Background: </strong>The urine immunochromatographic assay is a useful screening tool for patients suspected of acute drug intoxication in emergency conditions. Diphenhydramine intoxication shows symptoms similar to those of tricyclic antidepressant (TCA) intoxication.</p><p><strong>Case presentation: </strong>We examined a case of diphenhydramine intoxication showing cerebellar ataxia and prolonged false positive results for TCA in the urine. The urine TCA test showed persistently positive results even 60 h after the patient's initial drug screening. We observed negative conversion 90 h after the initial drug screening.</p><p><strong>Discussion: </strong>Considering the similarities of clinical symptoms between diphenhydramine and TCA intoxication, emergency physicians should consider the possibility of cross-reactivity in the diagnosis of a patient with unknown acute drug intoxication showing positive results of TCA immunochromatographic assay in the urine.</p><p><strong>Conclusion: </strong>The present case suggests that diphenhydramine overdose may cause cerebellar ataxia and show prolonged cross-reactivity as TCA in the urine.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10296078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and associated factors of congenital syphilis at a tertiary care center in Thailand.","authors":"Pimchanok Kulsirichawaroj,&nbsp;Dissajee Lumbiganon","doi":"10.2478/abm-2023-0039","DOIUrl":"https://doi.org/10.2478/abm-2023-0039","url":null,"abstract":"<p><strong>Background: </strong>The incidence of congenital syphilis is increasing worldwide, in parallel with the increase of syphilis in the general population.</p><p><strong>Objectives: </strong>This study aimed to determine the incidence and risk factors for congenital syphilis at a referral tertiary care center in Bangkok, Thailand.</p><p><strong>Methods: </strong>This is a case-control study using the hospital medical records of neonates born at our hospital, whose mothers had confirmed syphilis during pregnancy or at delivery between 2011 and 2018. Maternal and neonatal data were reviewed. Neonates were categorized into congenital syphilis according to CDC surveillance case definition for congenital syphilis 2015 and the American Academy of Pediatrics Congenital Syphilis 2018: confirmed and probable were assigned to the case group, while possible and less likely congenital syphilis were used as the control group. Factors associated with congenital syphilis were analyzed using univariable and multivariable analysis.</p><p><strong>Results: </strong>Among 19,558 live births, there were 126 neonates born to mothers with syphilis. Almost 40% of mothers were teenage mothers and 48.4% had inadequate or no syphilis treatment. Forty neonates met the criteria of congenital syphilis giving the incidence of 204 per 100,000 live births (95% confidence interval [CI]: 146-278). Factors associated with congenital syphilis were inadequate treatment of maternal syphilis and preterm birth (adjusted odd ratio [aOR]: 2.69, 95% CI: 1.02-7.11, <i>P</i> = 0.046 and aOR: 2.91; 95% CI: 1.01-8.39, <i>P</i> = 0.049, respectively).</p><p><strong>Conclusions: </strong>The incidence of congenital syphilis in our institution was high. Factors associated with congenital syphilis were inadequate treatment of maternal syphilis and preterm birth. Improvement of prenatal care should be emphasized.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}