血小板淋巴细胞比值对年轻急性缺血性卒中出血转化的早期预测价值

IF 0.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Huijun Wen, Ning Wang, Min Lv, Yue Yang, Hongmei Liu
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引用次数: 0

摘要

背景 急性缺血性脑卒中(AIS)的发病率越来越高,需要全面了解相关因素。出血性转化(HT)是 AIS 的一种严重并发症,受血小板诱导的炎症和淋巴细胞水平的影响。目的 测量血小板与淋巴细胞比值(PLR)对年轻 AIS 患者发生出血性转化的预测价值。方法 回顾性收集首次入院的年轻 AIS 患者(157 人)的数据。根据入院后是否发生 HT,将患者分为 HT 组(63 例)和非 HT 组(94 例)。采用美国国立卫生研究院卒中量表(NIHSS)评分来确定临床症状的严重程度。使用接收器操作特征(ROC)和曲线下面积(AUC)分析 PLR 与 HT 和 NIHSS 评分之间的关系,以评估 PLR 对 HT 发生的预测价值。结果 多变量分析显示,PLR 和 NIHSS 是 HT 的独立危险因素。观察组的 PLR 值与 NIHSS 评分呈正相关(r = 0.8075,P < 0.0001)。根据 PLR 预测 HT 的发生,AUC 为 0.713(95% CI,0.652-0.781),临界值为 109.073,敏感性和特异性分别为 0.806 和 0.674。结论 PLR 值可在一定程度上预测年轻 AIS 患者发生 HT 的可能性。根据 PLR 值采取有效措施提前预防高血压具有重要的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The early predictive value of platelet-to-lymphocyte ratio to hemorrhagic transformation of young acute ischemic stroke
Background The increasing incidence of acute ischemic stroke (AIS) necessitates a comprehensive understanding of the related factors. Hemorrhagic transformation (HT), a severe complication of AIS, is influenced by platelet-induced inflammation and lymphocyte levels. Objective To measure the predictive value of platelet-to-lymphocyte ratio (PLR) in the occurrence of HT in young AIS patients. Methods Data of young AIS patients (n = 157) admitted to the hospital for the first time were retrospectively collected. The patients were divided into HT (63 patients) and non-HT groups (94 patients) on the basis of whether HT had occurred after admission. The National Institute of Health stroke scale (NIHSS) score was used to determine the severity of clinical symptoms. The relationship between PLR and HT and NIHSS scores was analyzed to evaluate the predictive value of PLR in the occurrence of HT using receiver operating characteristic (ROC) and area under the curve (AUC). Results Multivariate analysis showed that PLR and NIHSS are independent risk factors of HT. The PLR value of the observation group was positively associated with the NIHSS score (r = 0.8075, P < 0.0001). According to the PLR prediction about the occurrence of HT, an AUC of 0.713 (95% CI, 0.652–0.781), a cut-off value of 109.073, and a sensitivity and specificity of 0.806 and 0.674, respectively, were obtained. Conclusions PLR value can predict the possibility of HT in young AIS patients to a certain extent. To take effective measures to prevent HT in advance has crucial clinical significance according to PLR value.
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来源期刊
Asian Biomedicine
Asian Biomedicine 医学-医学:研究与实验
CiteScore
1.20
自引率
0.00%
发文量
24
审稿时长
6-12 weeks
期刊介绍: Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.
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