Annals Of Work Exposures and Health最新文献

{"title":"Association of occupational testicular radiation exposure with offspring sex ratio.","authors":"Yasukazu Hijikata, Tsukasa Kamitani, Yosuke Yamamoto, Takahiro Itaya, Yoshinori Matsuoka, Koichi Morota, Haruki Funao, Masayuki Miyagi, Tadatsugu Morimoto, Haruo Kanno, Akinobu Suzuki, Yoshihisa Kotani, Ken Ishii","doi":"10.1093/annweh/wxae093","DOIUrl":"10.1093/annweh/wxae093","url":null,"abstract":"<p><strong>Objectives: </strong>The association between paternal occupational radiation exposure and the sex ratio of offspring remains controversial. Therefore, we aimed to explore testicular radiation exposure in spine surgeons and its association with their offspring's sex ratio.</p><p><strong>Methods: </strong>The Minimally Invasive Spine Treatment Society in Japan administered a survey in October 2020. Male surgeons were divided into high- and low-radiation exposure groups according to the type of lead protectors used during the time frame surrounding the child's conception. Apron-type lead protectors were associated with high exposure, while no radiation or using a coat-type protector was considered low exposure. Risk ratios were calculated via generalized estimating equations with a log link binomial distribution. A secondary analysis was conducted wherein the high-exposure group was further divided into 2 categories based on whether they were in a posture that facilitated exposure during the procedures.</p><p><strong>Results: </strong>A total of 209 male surgeons participated, providing responses regarding 436 children, of which 308 and 128 were associated with high and low radiation exposure, respectively. There were more female children in the high-exposure group (53% versus 39%). The adjusted risk ratio for the child being female with high exposure was 1.35 (95% CI: 1.04 to 1.73). A dose-response relationship was observed: the adjusted risk ratios for high exposure with and without an exposure-prone posture were 1.36 (1.04 to 1.78) and 1.30 (0.96 to 1.78), respectively.</p><p><strong>Conclusions: </strong>High radiation exposure to the testes is associated with a lower male-sex ratio in offspring. Medical professionals using radiation should ensure proper radiation protection.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"544-552"},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of 7 urinary metabolites of polycyclic aromatic hydrocarbons during a wildfire response as part of the Wildland Firefighter Exposure and Health Effects Study.","authors":"Alexander C Mayer, Kenneth W Fent, I-Chen Chen, Kathleen Navarro DuBose, Corey R Butler, Molly West, Antonia M Calafat, Julianne Cook Botelho, Christine Toennis, Juliana Meadows, Deborah Sammons","doi":"10.1093/annweh/wxaf024","DOIUrl":"10.1093/annweh/wxaf024","url":null,"abstract":"<p><p>The occupation of firefighting, including wildland firefighting, has been classified as a known human carcinogen by the International Agency for Research on Cancer. Wildland firefighters (WFFs) can be exposed to polycyclic aromatic hydrocarbons (PAHs) present in wildfire smoke, some of which are known or probable carcinogens. Currently, there is no approved respiratory protection for WFFs against wildfire smoke, making inhalation exposure to PAHs a health concern. Recent studies have also highlighted the risk of dermal exposure to PAHs for WFFs due to factors like elevated skin temperature, sweat, and the inability to shower or routinely conduct good skin hygiene practices during wildfire incidents. This pilot study aimed to assess PAH exposure among 19 WFFs in different job positions during a wildfire incident by determining urine concentrations of 7 PAH metabolites in samples collected before and after shifts across 3 days. Overall, we observed increases from pre- to post-shift for all 7 PAH metabolites when we combined all WFF samples across the 3 days. When we stratified by job position and by day, concentrations of the PAH metabolites significantly increased from pre- to post-shift for 88% (37/42) of the comparisons (P-values <0.05). Additionally, median post-shift creatinine-corrected concentrations of 2-hydroxynaphthalene exceeded the 95th percentile of the nonsmoking US general population in 67% (4/6) of comparisons. Post-shift concentrations of hydroxynaphthalenes also exceeded concentrations measured in structural firefighters responding to training fires. Overall, 2-hydroxynaphthalene was highest on Day 2 (median creatinine-corrected concentrations of 2-hydroxynaphthalene from pre- to post-shift increased 425% for crew member/overhead; 146% for saw team). Despite this finding, we did not observe significant differences by job position. However, future studies could evaluate how job position affects WFF exposures while also exploring how dermal and inhalation contribute to WFFs' PAH exposure burden.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"559-567"},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to bioaerosols in the Norwegian salmon processing industry.","authors":"Marte Renate Thomassen, Bjørg Eli Hollund, Türküler Özgümüs, Anne Mette Madsen, Anna Beate Overn Nordhammer, Hans Thore Smedbold, Magne Bråtveit, Anje Christina Höper, Berit Bang, Miriam Grgic, Maja Karlsen Linchausen, Jorunn Kirkeleit","doi":"10.1093/annweh/wxaf038","DOIUrl":"https://doi.org/10.1093/annweh/wxaf038","url":null,"abstract":"<p><strong>Objectives: </strong>Workers in salmon processing plants are at risk of respiratory diseases. The aim of this study was to describe the Norwegian salmon processing industry in respect to production-related factors that may influence the generation of bioaerosols in the work atmosphere, and to assess salmon processing workers' personal exposure to protein and endotoxin.</p><p><strong>Methods: </strong>The study comprised 222 workers from 9 plants. Fullshift personal exposure measurements of total protein (inhalable aerosol fraction, n = 380) and endotoxin (total aerosol sampler, n = 178) were collected on 4 consecutive workdays. Technical and process-related information was collected through plant visits and meetings with technical and production staff. Linear mixed-effect model was used, treating individuals as random effect and work area and work task within areas as fixed effects.</p><p><strong>Results: </strong>Plants differed in size, setup, processing procedures, and use of labor along the processing lines. Salmon processing overall geometric mean (GM) exposure to inhalable protein across the plants was highest in filleting area with 4.83 µg/m3 (geometric standard deviation [GSD] 3.16), followed by 3.91 µg/m3 (GSD 2.42) in slaughtering area, and 1.68 µg/m3 (GSD 2.40) in other areas. Endotoxin levels were generally low with the highest levels in slaughtering (GM 0.24 EU/m3; GSD 3.48), followed by other area (GM 0.19 EU/m3; GSD 4.05) and filleting (GM 0.10 EU/m3; GSD 2.51). The overall correlation between inhalable protein and endotoxin (total aerosol sampler) was poor (r = 0.13, P = 0.12).</p><p><strong>Conclusions: </strong>Salmon processing workers are exposed to airborne inhalable protein bioaerosols at levels similar to those measured over a decade ago, indicating that a systematic approach to reduce exposure levels is still needed. Given the known health risk, the industry and regulatory bodies need to intensify efforts to reduce exposure and protect workers' health. The variance in exposure levels to inhalable protein across plants, areas, and tasks might form the basis for better exposure-reducing strategies.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contamination of firefighters' merino wool and mixed fibre sweater and hood undergarments with polycyclic aromatic hydrocarbons.","authors":"Cecilie Rosting, Hilde P Notø, Dag G Ellingsen, Thea H Johansen, Raymond Olsen","doi":"10.1093/annweh/wxaf031","DOIUrl":"https://doi.org/10.1093/annweh/wxaf031","url":null,"abstract":"<p><strong>Background: </strong>Several authors have studied contamination of polycyclic aromatic hydrocarbons (PAHs) found on the outer gears of firefighters, but to our knowledge, none have investigated merino wool and mixed fibre undergarments used underneath the protective turnout gear. We therefore performed a comprehensive study regarding selected PAHs in pieces cut out from different areas of firefighter's sweaters and hood used in real fires and laundered after each use.</p><p><strong>Method: </strong>Hoods (38) and sweaters (58) were donated by 3 fire departments and from these garments 558 pieces of fabric were cut out. Extracts of the fabric pieces were analysed by liquid chromatography with ultraviolet and fluorescence detection for 7 PAHs: anthracene, benzo[a]pyrene, chrysene, fluoranthene, naphthalene, phenanthrene, and pyrene. In addition, a small study was performed to examine the removal of PAHs from sweaters during laundry.</p><p><strong>Results: </strong>Trace amounts of anthracene, benzo[a]pyrene, fluoranthene, and pyrene were detected both in merino wool and mixed fibre sweaters and hoods with highest concentrations for the hoods and lowest for the back of the sweaters. Highest concentration was found for the forehead position of the hoods. Significantly higher concentrations of PAHs were found in both hoods and sweaters containing the textile meta-aramid. Laundering reduced the amount of PAHs-in the sweaters but not completely.</p><p><strong>Conclusion: </strong>Trace levels of benzo[a]pyrene and 3 other PAHs could be found in firefighters routine laundered undergarments. Cleaning reduced the PAH levels but not completely, and textiles with meta-aramid contained more PAHs than those without. Merino wool and mixed fibre undergarments are used in many countries and the results are valuable outside this study.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of dental dust and aerosol emissions during odontoplasty: assessing potential respiratory health risks.","authors":"Michèle Clarysse, Pieter Bertier, Steven Verpaele, Anne Mette Madsen, Lieven Vlaminck","doi":"10.1093/annweh/wxaf033","DOIUrl":"https://doi.org/10.1093/annweh/wxaf033","url":null,"abstract":"<p><p>Equine dental disorders, such as sharp enamel points and focal overgrowths, are common in horses and are often treated with motorized dental grinding tools. These tools, while effective, produce dust and aerosols that may pose health risks to veterinarians and nearby individuals. This study aimed to assess the health risks associated with dental dust and aerosols generated during equine odontoplasty. Using a realistic setup, air concentrations of inhalable and respirable dust, crystalline silica, and airborne microorganisms and endotoxins were measured in 12 groups of horses undergoing odontoplasty with and without water-cooling. Results indicated that dust emission significantly increases during odontoplasty, but the concentrations of inhalable and respirable dust remained below occupational exposure limits. However, airborne microorganisms, including potential pathogenic fungal species and bacteria such as the methicillin-resistant bacterium Staphylococcus aureus, were detected as well as elevated endotoxin levels, suggesting an occupational health risk. Therefore, protective measures, such as wearing FFP3 masks, gloves, and glasses, are recommended during equine odontoplasty.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bus-exposure matrix, a tool to assess bus drivers' exposure to physicochemical hazards.","authors":"Viviane Fiona Mathilde Remy, Giles Innocent, David Vernez, Irina Guseva Canu","doi":"10.1093/annweh/wxaf036","DOIUrl":"https://doi.org/10.1093/annweh/wxaf036","url":null,"abstract":"<p><p>Swiss bus drivers suffer from musculoskeletal disorders, fatigue, and stress and have an excessive mortality from lung cancer and suicide compared to other workers. However, their occupational exposure is poorly documented. We created a bus-exposure matrix (BEM) to determine occupational exposures to 10 types of physical-chemical hazards for 705 bus models used in Switzerland since 1980. For this, we made a comprehensive bus inventory and review of 50 technical characteristics of each bus model, identified 10 bus models representative of the Swiss bus fleet evolution, and conducted static and dynamic exposure measurement campaigns in the representative buses. The measured values were then extended to the entire fleet using Integrated Nested Laplace Approximation (INLA) models. The choice of predictors and technical bus characteristics included in the models were based on directed acyclic graphs. To demonstrate the usefulness of the BEM as an exposure assessment tool, we used data from the 2022 survey of Swiss bus drivers who listed the bus models they had driven during their careers. The BEM linkage with these bus drivers' histories enabled us to estimate annual exposure to PM10 ratio (-), ultrafine particle ratio (-), whole-body vibration (m/s2), floor vibration (m/s2), equivalent noise (dB(A)), peak noise (dB(C)), high-frequencies electric fields (V/m), low-frequencies magnetic field (µT), low-frequencies electric fields (V/m), and air exchange rate (1/h) of 809 Swiss bus drivers. Historical data assessment from 1985 through 2022 showed that peak noise, high- and low-frequencies electric field levels have increased, while PM10 ratio, ultrafine particle ratio, equivalent noise, whole-body vibration levels, and air exchange rate have decreased. This, first in the world, BEM is an original tool for retrospective exposure assessment that will enable further research in the occupational health of bus drivers.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of dust and crystalline silica exposure during indoor demolition.","authors":"Johanne Ø Halvorsen, Pål Graff, Elin Lovise Folven Gjengedal, Torunn K Ervik","doi":"10.1093/annweh/wxaf028","DOIUrl":"https://doi.org/10.1093/annweh/wxaf028","url":null,"abstract":"<p><p>Exposure to dust and respirable crystalline silica (RCS) is a continuing concern in the construction industry when working with silica-containing materials, such as concrete, brick, or stone. Increased knowledge of the dust characteristics can be used to improve measures to reduce potential exposure. This study aimed to characterize dust collected from indoor demolition in terms of particle size distribution and mineral content, including quartz. Airborne dust was collected with Sioutas cascade impactors at five different construction sites involved in indoor demolition and renovation. Four of the locations had workers demolishing concrete, while at the fifth location brick structures were demolished. An aerodynamic particle sizer (APS) was used to continually monitor the particle number concentrations in the size range 0.54 µm to 17 µm. Material samples of demolished material were collected from each location to determine mineral content. The filters from the Sioutas cascade impactors were weighted to determine dust concentrations in five size fractions ranging from 10 µm down to less than 0.25 µm. Quartz concentrations were quantified with X-ray diffraction using the NIOSH 7500 method and Rietveld refinement was further used to determine other mineral content in the Sioutas impactor samples and material samples. Respirable dust and quartz concentrations were calculated from the Sioutas data. The mass- and number-based particle size distributions measured by the APS were similar for the four locations involved in concrete demolition, whereas the location working with brick had a different distribution. The concentration levels varied widely, and the highest levels were observed at an enclosed location with no natural ventilation where concrete demolition took place. Limited natural or mechanical ventilation led to an accumulation of smaller particles around 1 µm and a lower mass median aerodynamic diameter for RCS, down to 1.2 µm, compared to locations with ventilation. The quartz percentages of the dust collected by Sioutas impactors were found to increase with increasing particle size. The dust contained less quartz than the source material, and an up-concentration of softer minerals like calcite was observed. The knowledge of particle size distributions and concentration levels occurring in the field during indoor demolition is important to ensure effective measures to reduce worker exposure. The results highlight the importance of effective ventilation to reduce the accumulation of airborne particles.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure-response relationships for platinum salt sensitization in precious metal refinery workers: a 16-yr retrospective study.","authors":"Lidwien A M Smit, José Jacobs, Frits van Rooy, Dick Heederik, Remko Houba, Lützen Portengen","doi":"10.1093/annweh/wxaf030","DOIUrl":"https://doi.org/10.1093/annweh/wxaf030","url":null,"abstract":"<p><strong>Background: </strong>Occupational allergy to soluble chlorinated platinum (Pt) salts, also known as chloroplatinates, poses a serious health problem in precious metal refineries. We aimed to assess the exposure-response relationship between soluble Pt salts exposure and Pt salt sensitization (PSS) in a 16-yr retrospective cohort study (2000 to 2015).</p><p><strong>Methods: </strong>We analyzed routinely collected data from 5 Pt refineries. In total, 1,614 newly hired workers who entered the industry since 2000 regularly underwent skin prick tests. Exposure to soluble Pt salts was modeled using 2,982 personal air samples. The relationship between time-varying exposure levels and PSS development was analyzed by Cox proportional hazards regression, adjusting for smoking, atopy, and facility.</p><p><strong>Results: </strong>PSS was diagnosed in 117 workers (1.48 per 100 person-years of follow-up time) with median time to PSS of 1.9 yr, and with an estimated median exposure level of 53 ng/m3 (P5-P95: 8 to 302 ng/m3) at the time of PSS development. Statistically significant quantitative exposure-response relationships between PSS and cumulative and current exposure were found. Exposure-response curves showed a steep increase in PSS incidence at exposure levels up to 100 ng/m3, with no or only a slight further increase at higher levels.</p><p><strong>Conclusions: </strong>We found a clear exposure-response relationship between soluble Pt salts exposure and PSS incidence among newly hired workers. Despite the limitations inherent to the retrospective study design, this cohort study contributes to the growing body of evidence that the widely adopted occupational exposure limit of 2,000 ng/m3 does not adequately prevent PSS and should be reevaluated.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifications to the membrane filter method with phase-contrast microscopy (PCM) for fibre-counting to support a new occupational exposure limit value.","authors":"Martin Harper, Thomas W S Pang","doi":"10.1093/annweh/wxaf032","DOIUrl":"https://doi.org/10.1093/annweh/wxaf032","url":null,"abstract":"<p><p>The occupational exposure limit value (OELV) currently in force for the concentration of asbestos fibres in air in most of the world is 0.1 f cm-3. This value has been considered in some methods as the limit of detection (LOD) for the membrane filter method with phase-contrast microscopy (PCM). There is a directive within the European Union (EU Directive 2023/2668) to lower the OELV in member States to 0.01 f cm-3 from 21 December 2025. In the EU, OELVs are established with specific requirements for the expanded uncertainty around the target value, and to meet those requirements the OELV should not be a simple LOD. A value of approximately one-half of the OELV, if determined accurately, can give reasonable assurance of compliance with the OELV. There are several options available which can allow modification of the membrane filter method with PCM to measure 0.005 f.cm-3 as a time-weighted average (TWA) over a period of hours. As there will be fewer fibres on a sample, greater precision in counting is required. To achieve greater precision, (i) the filter background must be below 2.5 f.mm-2, which is achievable where filters are manufactured in a clean environment, (ii) microscopists must receive training and evaluation, e.g. through participation in a proficiency test program, and (iii) the sample size for counting will need to be increased by increasing the volume of air sampled and counting additional graticule areas. These modifications to the methods, taken together, should allow accurate measurements at 0.005 f cm-3, thus demonstrating compliance with an OELV of 0.01 f.cm-3 for a 4-h or 8-h TWA sample. Although these changes bring some additional cost in sampling and analysis, the PCM method could be retained. Continuing with the PCM methods has the advantages of low cost, capability for on-site analysis, and traceability to risk assessments based on prior PCM data.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to combustion by-products and breast cancer risk in postmenopausal women.","authors":"Kahlila Paul-Cole, France Labrèche, Mark S Goldberg, Sydney Westra, Vikki Ho","doi":"10.1093/annweh/wxaf035","DOIUrl":"https://doi.org/10.1093/annweh/wxaf035","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.</p><p><strong>Materials and methods: </strong>Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 combustion by-products (cooking fumes, diesel engine emissions, leaded and unleaded engine emissions, natural gas combustion products, and polycyclic aromatic hydrocarbons [PAHs]). Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for BC risk, both for all tumours and by tumour molecular subtypes, in relation to occupational exposure to the 6 selected combustion by-products.</p><p><strong>Results: </strong>No association was observed between occupational exposure to the 6 selected combustion by-products and postmenopausal BC. However, when considering molecular subtypes, women ever occupationally exposed to PAHs had a suggestive higher risk of Luminal B tumours (ORmodel6 = 2.09, 95% CI: 0.87 to 4.60) compared with those never exposed. Additionally, women ever occupationally exposed to cooking fumes compared with those never exposed had a suggestive higher risk of HER2-enriched tumours (ORmodel6 = 2.63, 95% CI: 0.98 to 6.40).</p><p><strong>Conclusion: </strong>Occupational exposure to the 6 selected combustion by-products was not associated with postmenopausal BC. Suggestive higher risks of certain molecular subtypes of BC were observed with exposure to PAHs and cooking fumes. Future larger studies should consider the role of occupational exposures in the aetiology of BC across different molecular subtypes.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}