Annals Of Work Exposures and Health最新文献

{"title":"Development of Korean CARcinogen EXposure: occupation-based exposure matrix.","authors":"Dong-Hee Koh, Sangjun Choi, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Inah Kim, Jeehee Min, Yujin Kim, Dong-Uk Park","doi":"10.1093/annweh/wxae090","DOIUrl":"10.1093/annweh/wxae090","url":null,"abstract":"<p><strong>Objectives: </strong>Information systems focusing on occupational carcinogen exposure, whether categorized by industry or occupation, play a pivotal role in the prevention of occupational cancers. Recently, the Korean CARcinogen EXposure (K-CAREX) system was developed to assess carcinogen exposure by industry. However, corresponding information categorized by occupation has yet to be developed. This study aimed to develop an occupation-based exposure matrix for occupational carcinogens as an extension of the K-CAREX framework.</p><p><strong>Methods: </strong>The Work Environment Measurement Database (WEMD) and the Special Health Examination Database (SHED) were combined to estimate exposure intensity by occupation. The WEMD supplied exposure levels, whereas the SHED provided occupation information. Additionally, the SHED served as the primary data source for constructing an indicator of exposure prevalence by occupation, utilizing standard occupational classification.</p><p><strong>Results: </strong>A total of 22 carcinogens were selected for evaluating exposure intensity, and 20 carcinogens were selected for assessing exposure prevalence. Exposure intensity and prevalence were assigned to 156 occupational groups based on these carcinogens. For instance, in terms of welding fume exposure, welders were assigned an exposure intensity rating of 3 and exhibited exposure prevalence of 26%.</p><p><strong>Conclusions: </strong>Our findings complement the previously developed K-CAREX, which offered an industry-based exposure matrix. The resultant comprehensive K-CAREX, incorporating both industry- and occupation-based matrices, can be utilized for occupational cancer prevention and epidemiological studies.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"191-200"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent trends in respirable crystalline silica and elemental carbon exposure in the Ontario, Canada mining industry.","authors":"Victoria H Arrandale, Ali Shakeel, Kevin Hedges, Kimberly O'Connell, Melanie Gorman Ng","doi":"10.1093/annweh/wxae094","DOIUrl":"10.1093/annweh/wxae094","url":null,"abstract":"<p><strong>Introduction: </strong>Mining is a high-hazard industry with significant occupational disease risks. Despite this there is limited data describing current exposure conditions. The aim of this short communication is to share recent exposure data from underground mines in Ontario, Canada.</p><p><strong>Methods: </strong>Data from underground mines were accessed through a freedom of information request. Data were cleaned and standardized. Data contained measurements of several hazards from 2013 to 2018; analysis focused on personal samples for respirable crystalline silica (RCS) and elemental carbon (EC) from 2014 to 2018. Descriptive statistics were calculated overall and by sampling year; comparisons were made to current occupational exposure limits. Linear regression models were constructed to examine time trends.</p><p><strong>Results: </strong>EC exposures decreased significantly, ~10% per year over the measurement period (2014 to 2018). Overall 14% of EC measurements were above the current mining exposure limit (0.12 mg/m3 EC) in Ontario, Canada. Results for silica did not show a statistically significant trend but did suggest a reduction of ~1.8% per year. Almost one-third of the RCS measurements were above the American Conference of Governmental Industrial Hygienists (ACGIH) recommended threshold (0.025 mg/m3).</p><p><strong>Conclusions: </strong>Current exposure data is needed to understand workers' exposure and support occupational disease prevention. Recent data from the Ontario mining industry suggests that exposure to elemental carbon decreased significantly from 2014 to 2018, but the annual reduction for silica exposure was not nearly as substantial. Mining workers continue to be exposed to levels of EC and RCS that are hazardous to health.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"220-224"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health effects of repeated exposures during wildland firefighting: a data-linkage cohort study from Alberta, Canada.","authors":"Nicola Cherry, Mike Fedun, Jean-Michel Galarneau, Doryen Senkevics, Tanis Zadunayski","doi":"10.1093/annweh/wxae089","DOIUrl":"10.1093/annweh/wxae089","url":null,"abstract":"<p><strong>Introduction: </strong>Very little is known about the effects on the health of work as a wildland firefighter over repeated fire seasons. In Alberta, where the fire season runs from 1 March to 31 October, the great majority of firefighters are hired seasonally. We examined whether there was a dose-response relationship between hours of firefighting and ill-health.</p><p><strong>Methods: </strong>A cohort was established linking employment records from Alberta Wildfire to administrative health data and cancer records. The employment records contained information on each deployment for all firefighters with employment from 1998 to 2022. Health records had details of diagnoses recorded at all physician consultations for the same period. Cancer records included diagnostic information for all confirmed cancers in the province. Exposure indices (hours worked) were related to health outcomes, with relative risk estimated by multilevel Poisson regression, using data lagged by 10 years for cancer outcomes.</p><p><strong>Results: </strong>Of 16,816 firefighters with employment records, 12,731 were matched on name, age, and sex in health records and were living in Alberta at the end of at least one fiscal year. One in three had only been employed for one fire season with 10% employed in 10 or more years. The overall mean cumulative exposure was 795 h with 568 h of sustained attack (SA). In multivariable regression, adjusted for age, sex, and inferred First Nation origin, the risk of chronic obstructive pulmonary disease (COPD) and pneumonia increased with hours of firefighting on foot and decreased with fighting less complex fires or holding a permanent appointment. Hours of firefighting in the year of health report were protective for cardiovascular disease (CVD) and mental ill-health but the risk of injury from external causes increased with firefighting hours. The risk of COPD, pneumonia, and asthma increased with cumulative hours over multiple fire seasons of SA firefighting and decreased with cumulative hours fighting less complex fires. Risks of CVD and mental ill-health were also positively related to cumulative hours of SA. No increase in risk was found with cancer incidence (all cancers, bladder cancer, lung cancer, skin: melanoma or nonmelanoma), with exposures unlagged or lagged by 10 years.</p><p><strong>Conclusion: </strong>Wildland firefighters were found to be at increased risk of lung conditions, both acutely in the year of firefighting and in subsequent years. No increased risk was found for cancer.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"132-146"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk assessment methods in occupational health and hygiene: a scoping review.","authors":"Andrew Floeder, Rachael M Jones, Susan F Arnold","doi":"10.1093/annweh/wxae095","DOIUrl":"10.1093/annweh/wxae095","url":null,"abstract":"<p><strong>Background: </strong>There are a variety of risk assessment methods to evaluate occupational hazards in the field of industrial hygiene. With the development of emerging technologies in the workforce, the previously established risk assessment methods may need to be adapted or new methods developed to address the risk of new hazards.</p><p><strong>Methods: </strong>A scoping review was conducted consistent with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data was extracted and analyzed using a matrix method before undergoing a narrative synthesis. Risk assessment methods were classified as traditional and nontraditional.</p><p><strong>Results: </strong>Seventy-nine articles were included in this scoping review, with 81% using traditional risk assessment methods and 19% using nontraditional methods.</p><p><strong>Discussion: </strong>Among the nontraditional methods was control banding, with the most recent applications focused on nanomaterials. This approach, which was borne out of the need for a systematic approach for identifying potential health risks that required the use of engineering controls to be used safely, may have an important role in the area of emerging technologies, where the pace of technological innovation outstrips the rate at which health risks can be assessed and characterized. Risk assessment methods with the capacity to look at groups of similar chemicals and chemical mixtures are needed to address emerging hazards associated with emerging technologies.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"120-131"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the validity of a perfluorooctane sulfonic acid exposure reconstruction using a measured serum concentration among workers with a wide range of exposure.","authors":"Jerry L Campbell, Matthew W Linakis, Anna K Porter, Emma M Rosen, Perry W Logan, Sarah E Kleinschmidt, Kara L Andres, Sue Chang, Oyebode A Taiwo, Geary W Olsen, Harvey J Clewell, Matthew P Longnecker","doi":"10.1093/annweh/wxae099","DOIUrl":"10.1093/annweh/wxae099","url":null,"abstract":"<p><strong>Background: </strong>Studies among workers with a wide range of exposure to perfluoroalkyl substances inform risk assessments. Perfluorooctane sulfonate (PFOS), a ubiquitous environmental contaminant, was recently examined in relation to mortality and cancer incidence in an occupationally exposed population by Alexander et al. in 2024. In that study, cumulative occupational exposure (mg/m3 PFOS-equivalents in air) was reconstructed using a job-exposure matrix and individual work history. While the exposure reconstruction had good face validity, an assessment of its performance in relation to serum PFOS levels would allow improved interpretation of the occupational epidemiology findings.</p><p><strong>Objective: </strong>The objective of this study was to assess the validity of the exposure reconstruction used by Alexander et al. (2024).</p><p><strong>Methods: </strong>A previous study by Olsen et al. (2003) measured serum PFOS levels in 1998 for 260 workers and because these workers were included in the epidemiologic study by Alexander et al. (2024), the study reported herein compared serum PFOS levels to those predicted using a simple compartmental pharmacokinetic model.</p><p><strong>Results: </strong>The Pearson correlation coefficient between the observed and pharmacokinetic model-predicted serum PFOS concentration was 0.80 (95% confidence interval, 0.75 to 0.84). The median ratio of predicted to observed serum concentrations was 12 (i.e. actual exposure was significantly less than predicted). The predicted serum PFOS concentrations were not sensitive to the parameters used in the pharmacokinetic model other than exposure concentration or absorption.</p><p><strong>Conclusions: </strong>The model did not predict absolute exposure well, probably because of personal protective equipment use not being accounted for and absorption of PFOS or precursors being lower than modeled. On the other hand, the model did a reasonably good job of ranking the workers' exposure, thus classification of workers according to relative amount of cumulative PFOS-equivalents was reasonably accurate in the study by Alexander et al. (2024) when validated using the measured serum PFOS data.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"160-172"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to respirable crystalline silica at an underground copper mine in Zambia.","authors":"Lubinda Nabiwa, Stephanus J L Linde, Adrian Habanyama, Patrick Hayumbu, Mwaba Sifanu, Masilu Daniel Masekameni","doi":"10.1093/annweh/wxae096","DOIUrl":"10.1093/annweh/wxae096","url":null,"abstract":"<p><strong>Introduction: </strong>Overexposure to respirable crystalline silica (RCS) can lead to the development of silicosis and other respiratory diseases. The mine under study was reported to have the highest number of certified cases of pneumoconiosis in Zambia in 2015, and in 2008, a study revealed that 56% of the RCS samples exceeded 0.05 mg/m3. This study aims to assess occupational exposure to RCS at this underground copper mine.</p><p><strong>Method: </strong>In this cross-sectional study, personal exposure monitoring was conducted using National Institute for Occupational Safety and Health's methods 0600 and 7602 (KBr pellet), and 114 samples were collected. Gravimetric analysis of respirable dust (RD) samples and quantification of RCS were performed at an ISO 17025:2005 accredited analytical laboratory. BOHS-NVvA 2022 standard was used for determining activity areas' overexposure.</p><p><strong>Results: </strong>The median, 95th percentile (P95), and maximum (Max) RD concentrations were 0.279, 1.650, and 3.7 mg/m3, respectively. For the RCS exposure, the median, P95, and Max RCS exposure concentrations were 0.02, 0.179, and 0.548 mg/m3, respectively. Thirteen (11.7%) of the 111 samples had exposure exceeding the Republic of South Africa (RSA) TWA-OEL of 0.1 mg/m3, and 11 out of 18 activity areas were statistically overexposed to RCS when applying the BOHS-NVvA 2022 standard.</p><p><strong>Discussion: </strong>The number of RCS samples exceeding 0.05 mg/m3 reduced from the 67% recorded in 2008 to 32.4% in this study. One factor that could have led to this reduction is the mine not working at full capacity during the sampling period. However, the lack of adherence to the occupational health and safety (OHS) guidelines by the miners still leads to personal exposure above the limits set by various countries.</p><p><strong>Conclusion: </strong>Exposure to RCS in more than half of the activity areas was not under control. Routine RCS monitoring in Zambian mines should be mandatory, as this is not an isolated case, though it is more of a challenge at this mine because of the high percentage of RCS in RD samples (18.5%). Miners should be continuously trained on the importance of adhering to the OHS guidelines. Furthermore, Zambia should consider adopting the RSA occupational exposure limit for RCS and the BOHS-NVvA 2022 standard for exposure level compliance testing.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"201-212"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational infections in brickmakers: a neglected public health concern.","authors":"Aldo Barajas-Ochoa","doi":"10.1093/annweh/wxae098","DOIUrl":"10.1093/annweh/wxae098","url":null,"abstract":"<p><p>Recent studies highlight brickmaking's environmental and biological impacts, ranging from environmental pollution to toxic exposures in brickmakers and residents of neighboring areas. However, the risk of infections associated with brickmaking is widely understudied. In low- and middle-income countries worldwide, the brickmaking industry often belongs to the informal labor sector. Many of the millions of individuals in the industry belong to disenfranchised groups affected by adverse determinants of health. Manual brickmaking is precarious and exposes workers to infectious risks, yet this field remains understudied. This manuscript aims to raise awareness of these infectious risks and calls for comprehensive research to understand and mitigate them.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"117-119"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of ultrafine particle number emission factors from building materials in standardized conditions.","authors":"Nicolas Concha-Lozano, Yan Muller, Philippe Favreau, Guillaume Suarez","doi":"10.1093/annweh/wxae083","DOIUrl":"10.1093/annweh/wxae083","url":null,"abstract":"<p><p>When comparing the particle emissivity for different materials and/or mechanical activities, a serious methodological issue emerges due to the dynamic nature of solid aerosols. Particle size distribution and concentration depend on initial particle emission that constantly evolves due to aerodynamic collisions. In this context, we propose a methodological approach and an experimental setup that enables to assess the release of fine/ultra-fine particles maintaining a steady-state inhalable mass concentration, here chosen at the Swiss occupational exposure level value for biopersistent granular particles (OEL: 10 mg/m3) in a controlled ventilation chamber. As a case study, this methodological protocol was tested in the occupational exposure scenario in which a series of insulating materials based on silica aerogel and conventional mortar and concrete were subjected to handling or sawing. Once the OEL was reached, the particle size distribution and morphology of the aerosols were characterized using direct reading instruments (scanning mobility sizer, aerosol photometer) and electron microscopy (SEM and TEM) analyses. As a main result, the presence of silica aerogel in the mortar did not modify the emission profile for submicronic particles during sawing in comparison to the bulk mortar. Emission factors for ultra-fine particles were found to be 88 × 106 and 81 × 106 particles/µg of inhalable dust for the aerogel mortar and bulk mortar, respectively. For concrete sawing, the number concentration of submicronic particles at the OEL is one order of magnitude greater. The aerogel-glass-wool handling generated similar particle number concentration at the OEL with ultra-fine particle emission factors of 647 × 106 particles/µg of inhalable dust, in comparison to 758 × 106 particles/µg of inhalable dust during dry concrete sawing. In conclusion, the methodology introduced in this work provides standardized particle emission factors for comparing materials and activities, while establishing a link between particle number emissions and occupational exposure limits.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"213-219"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects.","authors":"Susana Viegas, Carla Martins, Edna Ribeiro, Carina Ladeira, Hermínia Pinhal, Ana Nogueira, Sílvia Santos, Ana Tavares, Bruno Costa Gomes, Catarina Maia Afonso, Henriqueta Louro, Maria João Silva","doi":"10.1093/annweh/wxae091","DOIUrl":"10.1093/annweh/wxae091","url":null,"abstract":"<p><p>In the scope of the European Union (EU) human biomonitoring initiative, a multicentric study on different occupational settings from several European countries was performed, to provide information on occupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen. Biomonitoring approaches were used to obtain exposure data to support the implementation of new risk management measures and policy actions at the national and European levels. This work describes the Portuguese contribution to the study, which aimed to assess workers' exposure to Cr, by using exposure biomarkers (urinary chromium [U-Cr]), and industrial hygiene samples (air and hand wipes) and to link exposure to potential long-term health effects by using effect biomarkers. Exposure determinants influencing exposure were explored from the contextual information and human biomonitoring data. The ultimate goal of the study was to appraise the risk management measures contributing to minimize exposure and protect workers' health. Several occupational settings and activities were considered, including plating, welding, and painting. A control group from the Portuguese general population was also included. Data on age, sex, and smoking habits from both groups were considered in the statistical analysis. Information on the risk management measures available for workers was collected and used to identify the ones that mainly contributed to reduce exposure. Environmental monitoring and human biomonitoring revealed that painters were the highest exposed group. The use of respiratory protection equipment showed an influence on total U-Cr levels for workers involved in painting activities. Concerning early health effects, the painters presented also a significantly higher level of DNA and chromosomal damage in peripheral blood cells, as compared to the control group, suggesting a plausible association between exposure to Cr(VI) and early genotoxic effects. The results showed that workers are exposed to Cr(VI) in those occupational settings. These findings point to the need to improve the prevention and risk management measures and the implementation and enforcement of new regulatory actions at the national level.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":"147-159"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the epidemiology of man-made vitreous fibres and respiratory health outcomes.","authors":"Damien M McElvenny, Ireny Iskandar, Sarah Daniels, Matthew Gittins, Martie van Tongeren","doi":"10.1093/annweh/wxaf006","DOIUrl":"https://doi.org/10.1093/annweh/wxaf006","url":null,"abstract":"<p><strong>Objectives: </strong>The generic term man-made vitreous fibres (MMVFs) also known as man-made mineral fibres (MMMFs) denotes non-crystalline, fibrous inorganic material manufactured primarily from glass, rock, minerals, slag, glass, and processed inorganic oxides. The International Agency for Research on Cancer has classified rock (stone) wool, glass wool, and continuous glass filament as Group 3 (not classifiable for carcinogenicity). This study contains an updated systematic review and meta-analysis of respiratory health outcomes and MMMFs.</p><p><strong>Methods: </strong>Cinahl, EMBASE, Medline, Web of Science, and OpenGrey were searched for epidemiological studies of occupational MMMF exposure and malignant and non-malignant respiratory diseases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adopted for reporting. Meta-analyses were carried out separately for cohort and case-control studies.</p><p><strong>Results: </strong>A total of 25 studies were identified for inclusion in the systematic review, with 19 of these (9 cohort; 10 case-control) providing risk estimates for the meta-analyses. Of the cohort studies, 3 were carried out in Sweden, 2 each in Canada and the United States, one in France, and one several European countries. The start of follow-up ranged from 1933 to 1975. The meta-RR for lung cancer from cohort studies (incidence or mortality) was 1.15 (95% CI: 1.01 to 1.32), for laryngeal cancer was 1.03 (95% CI: 0.78 to 1.37), and for non-malignant respiratory diseases (NMRD) mortality was 0.89 (95% CI: 0.66 to 1.22). Of the case-control studies, 9 examined lung cancer and one laryngeal cancer. Three of the lung cancer studies were carried out in France and one each in Germany, Russia, Canada, and China, with one in several European countries and one was a nested case-control study of several case cohorts from across the globe. The meta-OR for lung cancer from the case-control studies was 1.28 (95% CI: 1.10 to 1.50).</p><p><strong>Conclusions: </strong>Our findings broadly agree with a previously published meta-analysis of respiratory system cancers, in that they were similar in terms of magnitude of relative risk. However, overall, our results suggest that exposure to MMMFs is associated with a small, but statistically significantly elevated risk for lung cancer, but not for laryngeal cancer or NMRDs. Given the heterogeneity between studies, and the possibility of residual confounding, further work is required to determine if this association is causal.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}