Kahlila Paul-Cole, France Labrèche, Mark S Goldberg, Sydney Westra, Vikki Ho
{"title":"绝经后妇女职业接触燃烧副产物与乳腺癌风险","authors":"Kahlila Paul-Cole, France Labrèche, Mark S Goldberg, Sydney Westra, Vikki Ho","doi":"10.1093/annweh/wxaf035","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.</p><p><strong>Materials and methods: </strong>Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 combustion by-products (cooking fumes, diesel engine emissions, leaded and unleaded engine emissions, natural gas combustion products, and polycyclic aromatic hydrocarbons [PAHs]). Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for BC risk, both for all tumours and by tumour molecular subtypes, in relation to occupational exposure to the 6 selected combustion by-products.</p><p><strong>Results: </strong>No association was observed between occupational exposure to the 6 selected combustion by-products and postmenopausal BC. However, when considering molecular subtypes, women ever occupationally exposed to PAHs had a suggestive higher risk of Luminal B tumours (ORmodel6 = 2.09, 95% CI: 0.87 to 4.60) compared with those never exposed. Additionally, women ever occupationally exposed to cooking fumes compared with those never exposed had a suggestive higher risk of HER2-enriched tumours (ORmodel6 = 2.63, 95% CI: 0.98 to 6.40).</p><p><strong>Conclusion: </strong>Occupational exposure to the 6 selected combustion by-products was not associated with postmenopausal BC. Suggestive higher risks of certain molecular subtypes of BC were observed with exposure to PAHs and cooking fumes. Future larger studies should consider the role of occupational exposures in the aetiology of BC across different molecular subtypes.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Occupational exposure to combustion by-products and breast cancer risk in postmenopausal women.\",\"authors\":\"Kahlila Paul-Cole, France Labrèche, Mark S Goldberg, Sydney Westra, Vikki Ho\",\"doi\":\"10.1093/annweh/wxaf035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.</p><p><strong>Materials and methods: </strong>Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 combustion by-products (cooking fumes, diesel engine emissions, leaded and unleaded engine emissions, natural gas combustion products, and polycyclic aromatic hydrocarbons [PAHs]). Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for BC risk, both for all tumours and by tumour molecular subtypes, in relation to occupational exposure to the 6 selected combustion by-products.</p><p><strong>Results: </strong>No association was observed between occupational exposure to the 6 selected combustion by-products and postmenopausal BC. However, when considering molecular subtypes, women ever occupationally exposed to PAHs had a suggestive higher risk of Luminal B tumours (ORmodel6 = 2.09, 95% CI: 0.87 to 4.60) compared with those never exposed. Additionally, women ever occupationally exposed to cooking fumes compared with those never exposed had a suggestive higher risk of HER2-enriched tumours (ORmodel6 = 2.63, 95% CI: 0.98 to 6.40).</p><p><strong>Conclusion: </strong>Occupational exposure to the 6 selected combustion by-products was not associated with postmenopausal BC. Suggestive higher risks of certain molecular subtypes of BC were observed with exposure to PAHs and cooking fumes. Future larger studies should consider the role of occupational exposures in the aetiology of BC across different molecular subtypes.</p>\",\"PeriodicalId\":8362,\"journal\":{\"name\":\"Annals Of Work Exposures and Health\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals Of Work Exposures and Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/annweh/wxaf035\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals Of Work Exposures and Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/annweh/wxaf035","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Occupational exposure to combustion by-products and breast cancer risk in postmenopausal women.
Objective: To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.
Materials and methods: Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 combustion by-products (cooking fumes, diesel engine emissions, leaded and unleaded engine emissions, natural gas combustion products, and polycyclic aromatic hydrocarbons [PAHs]). Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for BC risk, both for all tumours and by tumour molecular subtypes, in relation to occupational exposure to the 6 selected combustion by-products.
Results: No association was observed between occupational exposure to the 6 selected combustion by-products and postmenopausal BC. However, when considering molecular subtypes, women ever occupationally exposed to PAHs had a suggestive higher risk of Luminal B tumours (ORmodel6 = 2.09, 95% CI: 0.87 to 4.60) compared with those never exposed. Additionally, women ever occupationally exposed to cooking fumes compared with those never exposed had a suggestive higher risk of HER2-enriched tumours (ORmodel6 = 2.63, 95% CI: 0.98 to 6.40).
Conclusion: Occupational exposure to the 6 selected combustion by-products was not associated with postmenopausal BC. Suggestive higher risks of certain molecular subtypes of BC were observed with exposure to PAHs and cooking fumes. Future larger studies should consider the role of occupational exposures in the aetiology of BC across different molecular subtypes.
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About the Journal
Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?"
We are interested in high quality scientific research addressing:
the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures;
the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities;
populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers;
the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems;
policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities;
methodologies and mechanisms that underlie the quantification and/or control of exposure and risk.
There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.
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