Occupational exposure to combustion by-products and breast cancer risk in postmenopausal women.

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals Of Work Exposures and Health Pub Date : 2025-06-16 DOI:10.1093/annweh/wxaf035

Kahlila Paul-Cole, France Labrèche, Mark S Goldberg, Sydney Westra, Vikki Ho

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引用次数: 0

Abstract

Objective: To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.

Materials and methods: Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 combustion by-products (cooking fumes, diesel engine emissions, leaded and unleaded engine emissions, natural gas combustion products, and polycyclic aromatic hydrocarbons [PAHs]). Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for BC risk, both for all tumours and by tumour molecular subtypes, in relation to occupational exposure to the 6 selected combustion by-products.

Results: No association was observed between occupational exposure to the 6 selected combustion by-products and postmenopausal BC. However, when considering molecular subtypes, women ever occupationally exposed to PAHs had a suggestive higher risk of Luminal B tumours (ORmodel6 = 2.09, 95% CI: 0.87 to 4.60) compared with those never exposed. Additionally, women ever occupationally exposed to cooking fumes compared with those never exposed had a suggestive higher risk of HER2-enriched tumours (ORmodel6 = 2.63, 95% CI: 0.98 to 6.40).

Conclusion: Occupational exposure to the 6 selected combustion by-products was not associated with postmenopausal BC. Suggestive higher risks of certain molecular subtypes of BC were observed with exposure to PAHs and cooking fumes. Future larger studies should consider the role of occupational exposures in the aetiology of BC across different molecular subtypes.

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绝经后妇女职业接触燃烧副产物与乳腺癌风险

目的：评估终身职业暴露于特定燃烧副产物与绝经后乳腺癌（BC）风险之间的关系。材料和方法：数据来自一项基于人群的病例对照研究，研究对象为居住在魁北克省montracimal的绝经后妇女。病例包括661名年龄在47至75岁之间的女性，在2008年至2011年期间被诊断为恶性BC。对照组包括从魁北克选举名单中随机选出的587名妇女，与5岁年龄组的病例频率相匹配。通过访谈收集风险因素和终生职业史信息。两名工业卫生学家利用工作经历确定了对293种物质的暴露，包括6种燃烧副产品（烹饪烟雾、柴油发动机排放、含铅和无铅发动机排放、天然气燃烧产物和多环芳烃[PAHs]）。使用无条件逻辑回归来估计所有肿瘤和肿瘤分子亚型的BC风险的调整优势比（ORs）和95%置信区间（CIs），这些风险与职业暴露于6种选定的燃烧副产物有关。结果：没有观察到职业暴露于6种选定的燃烧副产物和绝经后BC之间的关联。然而，当考虑分子亚型时，与从未暴露于多环芳烃的女性相比，曾经职业暴露于多环芳烃的女性患腔B肿瘤的风险较高（ORmodel6 = 2.09, 95% CI: 0.87至4.60）。此外，与从未接触过烹饪烟雾的女性相比，曾经接触过烹饪烟雾的女性患her2富集肿瘤的风险更高（ORmodel6 = 2.63, 95% CI: 0.98至6.40）。结论：职业性暴露于6种选定的燃烧副产物与绝经后BC无关。暴露于多环芳烃和烹饪烟雾中观察到某些分子亚型BC的高风险。未来更大规模的研究应考虑职业暴露在不同分子亚型BC病因学中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals Of Work Exposures and Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.60

自引率

19.20%

发文量

期刊介绍： About the Journal Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?" We are interested in high quality scientific research addressing: the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures; the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities; populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers; the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems; policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities; methodologies and mechanisms that underlie the quantification and/or control of exposure and risk. There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.