Archives of gerontology and geriatrics最新文献

{"title":"Global, regional, and national burden of vertebral fractures due to falls from 1990 to 2021 and predictions for the next 15 years: A systematic analysis of the global burden of disease 2021 study","authors":"Xue Yun ,&nbsp;Lintao Zhang ,&nbsp;Zhaopeng Fan ,&nbsp;Yuxin Fu ,&nbsp;Hua Guo","doi":"10.1016/j.archger.2025.105874","DOIUrl":"10.1016/j.archger.2025.105874","url":null,"abstract":"<div><h3>Objectives</h3><div>This study utilized the latest data from the 2021 Global Burden of Disease Study to analyze the incidence, prevalence, and years lived with disability due to vertebral fractures from 1990 to 2021, providing information for effective management and prevention strategies.</div></div><div><h3>Methods</h3><div>This study describes the trends in incidence, prevalence, and years lived with disability (YLDs) due to vertebral fractures caused by falls. It employs methods such as the Age-Period-Cohort (APC) model, joinpoint regression analysis, and decomposition analysis for further investigation, and calculates the ASIR, ASPR, and ASYR. Finally, it predicts the incidence trend for the next 15 years using the Autoregressive Integrated Moving Average (ARIMA) model.</div></div><div><h3>Results</h3><div>In 2021, the number of new cases of vertebral fractures due to falls globally reached 4.7 million, with a total prevalence of 3.67 million cases, and years lived with disability (YLDs) amounted to 370,000. Compared to 1990, the estimated annual percentage change (EAPC) was -0.37 (-0.41, -0.32), -0.35 (-0.39, -0.31), and -0.37 (-0.41, -0.33) respectively, indicating a declining trend. There are significant differences in the disease burden among different countries and regions. The APC model, Joinpoint model, and ARIMA forecasting model indicate a global declining trend in the disease burden of vertebral fractures.</div></div><div><h3>Conclusions</h3><div>Although the burden of vertebral fractures is on a downward trend, it continues to increase in low and middle SDI regions, as well as among the elderly population. Therefore, targeted preventive measures are still necessary to address the health outcomes related to vertebral fractures.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105874"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond SHAP: Reliable feature selection methods for clinical prediction models","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.archger.2025.105873","DOIUrl":"10.1016/j.archger.2025.105873","url":null,"abstract":"<div><div>This study critically examines the limitations of model-dependent feature importance methods used in clinical prediction modeling, specifically addressing inconsistencies in Xu et al.'s (2025) depression prediction research. We demonstrate how algorithm selection fundamentally alters featured rankings despite similar prediction accuracies, revealing a methodological gap where accuracy validation exists but feature importance validation does not. We propose a comprehensive alternative framework combining statistical and information-theoretic approaches: (1) monotonic relationship detection using Spearman's correlation and Kendall's tau with p-value assessment, and (2) complex interaction analysis using Mutual Information and Effective Transfer Entropy. This dual methodology enables identification of both straightforward variable associations and complex nonlinear dependencies, providing more robust and reliable insights for clinical prediction models.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105873"},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor","authors":"Louis J Koizia ,&nbsp;Vincent E.S Allott ,&nbsp;Michael B. Fertleman ,&nbsp;Benjamin H.L Harris","doi":"10.1016/j.archger.2025.105869","DOIUrl":"10.1016/j.archger.2025.105869","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105869"},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the vicious cycle: Reciprocal influences between social isolation and functional disability and the buffering effect of digital inclusion","authors":"Mingyu Cui ,&nbsp;Yang Liu ,&nbsp;Mengjiao Yang ,&nbsp;Kumi Watanabe Miura ,&nbsp;Jinrui Zhang ,&nbsp;Tokie Anme","doi":"10.1016/j.archger.2025.105871","DOIUrl":"10.1016/j.archger.2025.105871","url":null,"abstract":"<div><div>In aging societies like Japan, social isolation (SI) and functional disability (FD) critically impact older adults’ health, yet their bidirectional relationship and potential moderators remain underexplored. This prospective cohort study examined the bidirectional SI-FD association and tested digital inclusion’s (DI) moderating role among community-dwelling Japanese older adults.</div><div>We analyzed 480 adults aged ≥65 across three waves (baseline, 3-year, 6-year follow-ups) using multi-group random intercept cross-lagged panel models (RI-CLPM) to disentangle within-person and between-person effects.</div><div>At the between-person level, SI was positively connected with FD (β = 0.50, <em>p</em> &lt; 0.001). Within individuals, SI and FD demonstrated reciprocal worsening over time, with SI’s cross-lagged effect on subsequent FD (T1→T2: β = 0.42, <em>p</em> &lt; 0.001; T2→T3: β = 0.40, <em>p</em> &lt; 0.001) exceeding FD’s effect on SI (T1→T2: β = 0.21, <em>p</em> &lt; 0.01; T2→T3: β = 0.29, <em>p</em> &lt; 0.01). DI significantly attenuated SI’s adverse impacts: in the digitally included group (<em>n</em> = 291), SI’s autoregressive effects and cross-lagged effects on FD became nonsignificant (<em>p</em> &gt; 0.05), SI’s cross-lagged effect on subsequent FD also weakened (T1→T2: β = 0.19, <em>p</em> &lt; 0.05; T2→T3: β = 0.22, <em>p</em> &lt; 0.05).</div><div>Findings suggest bidirectional SI-FD links are partially mitigated by digital engagement. While social interventions remain critical, integrating digital literacy programs may disrupt SI’s cascading effects on disability. Study limitations include regional sampling and self-reported measures. Future research should validate these mechanisms across diverse populations and explore targeted digital-social hybrid interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105871"},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Friends and trends: Friendship across life phases and cohorts","authors":"Erika Augustsson ,&nbsp;Roger Keller Celeste ,&nbsp;Stefan Fors ,&nbsp;Johan Rehnberg ,&nbsp;Carin Lennartsson ,&nbsp;Neda Agahi","doi":"10.1016/j.archger.2025.105872","DOIUrl":"10.1016/j.archger.2025.105872","url":null,"abstract":"<div><h3>Objective</h3><div>This study describes how subjective frequency of contact with friends changes over the lifespan, whether it has increased across cohorts, and if later-born cohorts maintain this contact into older ages.</div></div><div><h3>Methods</h3><div>Cross-sectional data from individuals aged 15–97 collected between 1968 and 2021 were used to create an age pattern, analyse changes within age groups, and compare self-reported age trajectories of frequent contact with friends across birth cohorts.</div></div><div><h3>Results</h3><div>Reported frequency of contact with friends follows a clear age pattern: decreasing from young adulthood, plateauing in midlife, and decreasing again in older age. Later-born cohorts are more likely to report frequent contact with friends, but this difference converges in older age. There is no strong evidence that later-born cohorts maintain frequent contact with friends into old age, though upcoming cohorts may show changes in this trend.</div></div><div><h3>Discussion</h3><div>As life expectancy and overall health in older age improve, understanding the role of contact with friends in supporting well-being becomes increasingly important. The convergence of the frequency of contact with friends across cohorts in older age could lead to unmet expectations of social contact in upcoming cohorts. Therefore, continued research and proactive measures to support social interactions throughout the ageing process could enhance social connectedness in ageing populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105872"},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual obstacle-avoidance training using daily-life obstacles with physical feedback in older people: A cross-over trial","authors":"Yixuan He ,&nbsp;Jamie Lee ,&nbsp;Juno Kim ,&nbsp;Matthew A. Brodie ,&nbsp;George Mitri ,&nbsp;Kimberley S. van Schooten ,&nbsp;Nigel H. Lovell ,&nbsp;Stephen R. Lord ,&nbsp;Yoshiro Okubo","doi":"10.1016/j.archger.2025.105866","DOIUrl":"10.1016/j.archger.2025.105866","url":null,"abstract":"<div><div>Failures in avoiding environmental hazards can lead to falls. We developed a virtual reality (VR) obstacle-avoidance training system that provides physical feedback upon foot contact with a virtual obstacle. This study aimed to assess whether physical feedback reduces obstacle collisions in older adults within a VR environment. Fifty-six participants (mean age 72.3 ± 5.4 (SD) years) wore an immersive VR head-mounted display and safety harness and walked on a split-belt treadmill in two 8-minute conditions performed in random order. They walked on a virtual suburban footpath, collecting virtual apples and avoiding slip-and-trip obstacles. In the perturbation condition (VR+<em>P</em>), foot-obstacle collisions were accompanied by immediate physical feedback via treadmill belt accelerations/decelerations. In the non-perturbation condition (VR-only), no physical feedback was provided. Obstacle collision rates and subjective acceptability were assessed. In the VR+<em>P</em> condition, participants had fewer obstacle collisions (0.63 versus 0.75), fewer trailing foot collisions (0.57 versus 0.68) and a greater margin of stability compared with the VR-only condition (<em>p</em> &lt; 0.05). Participants reported significantly higher levels of anxiety and greater task difficulty for the VR+<em>P</em> condition (<em>p</em> &lt; 0.05). Motion sickness was rarely reported, and enjoyment ratings were high, with no significant differences between the conditions. In summary, physical feedback reduced obstacle collisions and increased gait stability. The low levels of motion sickness and anxiety and high levels of enjoyment reported suggest that VR obstacle avoidance training is highly acceptable to older people. Future research is required to determine the generalisation of improved motor skills to real-world scenarios.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105866"},"PeriodicalIF":3.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses","authors":"Dongze Chen ,&nbsp;Yali Zhang ,&nbsp;Zhiqiang Ji ,&nbsp;Yi Zhou ,&nbsp;Zhisheng Liang","doi":"10.1016/j.archger.2025.105862","DOIUrl":"10.1016/j.archger.2025.105862","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between frailty and the progression trajectories of stroke-dementia comorbidity remains inconclusive. This study aimed to determine whether there are associations between frailty and the progression trajectories of stroke-dementia comorbidity, including the transitions from enrollment to incident stroke/dementia, progression to stroke-dementia comorbidity, and ultimately to mortality.</div></div><div><h3>Methods</h3><div>This prospective study was conducted based on the UK Biobank cohort. Frailty was assessed using the frailty index (FI) and categorized as robust (FI ≤ 0.10), prefrail (0.10 &lt; FI ≤ 0.25), or frail (FI &gt; 0.25). We used multi-state models and one-sample Mendelian randomization (MR) to investigate the relationships between frailty and the progression trajectories of stroke-dementia comorbidity. Population attributable fraction (PAF) analyses were conducted to assess the attributable risks of frailty and its components.</div></div><div><h3>Results</h3><div>The final analysis included 459,924 participants. In comparison to the robust, the frail group significantly elevated the risk of transitioning from enrollment to stroke [HR(95 %CI): 2.32(2.19–2.45)], from enrollment to dementia [2.56(2.31–2.83)], from enrollment to mortality [2.32(2.23–2.42)], from stroke to stroke-dementia comorbidity [1.59(1.23–2.05)], from dementia to stroke-dementia comorbidity [1.79(1.29–2.48)], and from stroke to mortality [1.25(1.11–1.40)]. MR analyses revealed that genetically predicted FI was causally associated with higher risks of stroke-dementia comorbidity. PAF analyses indicated that hypertension, diabetes, lung disease, and visual impairment were significant contributors to the risk of progression to stroke-dementia comorbidity.</div></div><div><h3>Conclusion</h3><div>Our findings revealed that frailty status increases the risk of post-stroke dementia, offering important insights for the clinical management and public health strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105862"},"PeriodicalIF":3.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic blood pressure patterns and their significance in aging","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105868","DOIUrl":"10.1016/j.archger.2025.105868","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105868"},"PeriodicalIF":3.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and its dimensions in relation to functional ability in older adults: A systematic review and meta-analysis","authors":"Yilin Cheng,&nbsp;Weiyao Li,&nbsp;Shuqin Xiao,&nbsp;Yuxin Chen,&nbsp;Xiaoyan Qi","doi":"10.1016/j.archger.2025.105860","DOIUrl":"10.1016/j.archger.2025.105860","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to explore the association between declines in intrinsic capacity and its individual domains with functional impairment in older adults and to compare the predictive ability of overall intrinsic capacity and its specific domains for functional disability.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Embase, Cochrane Library, Web of Science, SinoMed, CNKI, Wanfang, and VIP databases from inception to December 26, 2024. Meta-analysis was conducted using RevMan 5.4. Study quality was assessed with the Newcastle-Ottawa Scale, and evidence quality was evaluated using GRADE guidelines. The study protocol was registered in PROSPERO (CRD42025634431).</div></div><div><h3>Results</h3><div>This meta-analysis included 15 longitudinal studies with 53,648 participants. Declines in locomotion, cognition, psychological well-being, and vitality were significantly associated with increased Activities of Daily Living (ADL) disability risk. Vision impairment also elevated ADL disability risk but hearing loss did not. Overall intrinsic capacity decline was linked to higher ADL disability risk (OR = 1.22, 95 % CI [1.16, 1.28]), with locomotion demonstrating stronger predictive power than overall intrinsic capacity. For instrumental activities of daily living (IADL) disability, declines in locomotion, cognition, psychological well-being, and vitality were significant risk factors. Sensory functions showed no significant association. Overall intrinsic capacity decline was strongly associated with IADL disability risk (OR = 1.41, 95 % CI [1.29, 1.54]), with no individual dimension showing significantly greater predictive power than overall intrinsic capacity. The GRADE evidence quality was rated as moderate.</div></div><div><h3>Conclusions</h3><div>This study confirms the role of overall intrinsic capacity and its individual domains in predicting functional impairment in older adults. It also compares the predictive value of overall intrinsic capacity with that of its specific domains, identifying locomotion decline as a key driver of functional impairment. Future research should further explore the longitudinal interactions among multiple intrinsic capacity domains using standardized intrinsic capacity assessment methods to refine the theoretical framework of healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105860"},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring associations between dual sensory impairment and neuropsychiatric disorders: Insights from a prospective cohort study in the UK Biobank","authors":"Hai-Hua Guo ,&nbsp;Wei Zhang ,&nbsp;Shuang-Ling Han ,&nbsp;Ya-Nan Ou ,&nbsp;Yan Fu ,&nbsp;Pei-Yang Gao ,&nbsp;Qiong-Yao Li ,&nbsp;Hao-Chen Chi ,&nbsp;Wei Xu ,&nbsp;Lan Tan ,&nbsp;Hui-Fu Wang","doi":"10.1016/j.archger.2025.105865","DOIUrl":"10.1016/j.archger.2025.105865","url":null,"abstract":"<div><h3>Background</h3><div>Evidence of dual sensory impairment (DSI) characterized by comorbid hearing impairment (HI) and visual impairment (VI) is limited in neuropsychiatric disorders. Moreover, the underlying mechanisms remain elusive.</div></div><div><h3>Methods</h3><div>Using data from 169,165 UK Biobank participants, we compared cognition and mental health across the no sensory impairment, HI, VI, and DSI groups and investigated the association between the number of sensory impairments and neuropsychiatric disorders in longitudinal COX analyses. We also analyzed the associations of sensory function and its interaction with brain structure, functional connectivity, inflammatory markers, and metabolites and explored their mediating roles.</div></div><div><h3>Results</h3><div>DSI participants exhibited poor cognition and mental health, and had a higher risk of neuropsychiatric disorders compared to those with HI/VI alone. Both HI and VI were linked to atrophic changes in the hippocampus, thalamus, precuneus, parietal cortex, middle temporal gyrus, etc., and reduced white matter integrity. Brain regions associated with HI and VI exhibited decreased functional connectivity with other cortexes. Hearing and visual performance exhibit a significant interaction in relation to cognitive function, mental health, and metabolites. Brain structures, inflammation, and metabolic biomarkers significantly associated with HI and VI mediated the relationship between sensory impairments and cognition/mental health.</div></div><div><h3>Conclusion</h3><div>Compared to HI/VI alone, DSI is associated with poorer cognitive function, mental health, and a higher risk of neuropsychiatric disorders, potentially driven by the interaction between HI and VI. Additionally, HI and VI are linked to brain atrophy, reduced white matter integrity, and altered functional connectivity. Furthermore, brain structure, inflammation, and metabolic biomarkers mediate the relationship between sensory impairments and cognition/mental health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105865"},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}