Archives of gerontology and geriatrics最新文献

{"title":"Systematic review of interventions for pre-frail and frail older adults: Evidence from clinical trials on frailty levels","authors":"Andressa C. da Silva Sobrinho ,&nbsp;Reisa Cristiane de Paula Venancio ,&nbsp;Guilherme da Silva Rodrigues ,&nbsp;Mariana Porto ,&nbsp;Layana Liss Schwenger ,&nbsp;Letícia Fernanda Belo ,&nbsp;Luana K. Ferreira ,&nbsp;Carlos Roberto Bueno Júnior ,&nbsp;Grace Angelica de Oliveira Gomes","doi":"10.1016/j.archger.2025.105851","DOIUrl":"10.1016/j.archger.2025.105851","url":null,"abstract":"<div><h3>Introduction</h3><div>The increasing global longevity underscores the necessity of effective interventions for older adults. Pre-frailty and frailty affect 54.1 % and 26.3 % of the elderly population, respectively, leading to adverse physical and cognitive outcomes. This study systematically reviewed the effectiveness of interventions targeting robust, pre-frail, and frail older adults in randomized controlled trials, analyzing frailty levels both collectively and individually.</div></div><div><h3>Methods</h3><div>Following the Joanna Briggs Institute (JBI) methodology and PRISMA guidelines, seven databases were searched for studies published between 2018 and 2023. Randomized controlled trials involving individuals aged ≥65 years were included. Methodological quality was assessed using the PEDro scale, with scores ranging from 7 to 10, indicating moderate to high quality.</div></div><div><h3>Results</h3><div>A total of 3416 records were identified, and 40 studies were included, encompassing 17,822 participants (82.3 % women, mean age: 68–79 years). Physical exercise interventions accounted for 42.5 % of the studies, while multicomponent programs constituted 27.5 %. Improvements in frailty levels were reported in 32.5 % of the studies, with significant gains in quality of life (+15.2 %), gait speed (+0.22 m/s), and muscle strength (+18.7 %). Pre-frail individuals exhibited the greatest responsiveness to interventions, reflecting their remaining adaptability and potential for improvement.</div></div><div><h3>Discussion</h3><div>Multifaceted interventions were found to be particularly effective for pre-frail individuals, emphasizing the need for standardized criteria for frailty assessment. Geographic variability and inconsistencies in assessment methods were noted. Physical activity emerged as a key component in improving outcomes, with most interventions led by physiotherapists and physical education professionals.</div></div><div><h3>Conclusion</h3><div>Integrated interventions significantly enhance health and functionality, particularly for pre-frail older adults, underscoring the importance of early and tailored approaches. This study highlights the need for standardized guidelines and multidisciplinary strategies to address the heterogeneity of the aging population effectively.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105851"},"PeriodicalIF":3.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of frailty index and biological aging with all-cause and cause-specific mortality: a population-based longitudinal cohort study","authors":"Shichen Zhou ,&nbsp;Guang Chen ,&nbsp;Tung-Leong Fong ,&nbsp;Guoyi Tang ,&nbsp;Ruogu Xiong ,&nbsp;Ya Xuan Sun ,&nbsp;Junjie Lu ,&nbsp;Ning Wang ,&nbsp;Yibin Feng","doi":"10.1016/j.archger.2025.105856","DOIUrl":"10.1016/j.archger.2025.105856","url":null,"abstract":"<div><h3>Background</h3><div>The role of frailty in all-cause, cardiovascular, and cancer mortality is debatable, and the modification effect of biological aging remains unclear. Therefore, we aimed to evaluate the joint association of frailty index and biological aging with all-cause and cause-specific mortality.</div></div><div><h3>Methods</h3><div>In this population-based cohort study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) and National Death Index (NDI). Demographic variables were extracted, frailty index was constructed, and biological aging was calculated. All-cause deaths, cancer deaths, and cardiovascular disease (CVD) deaths were extracted as outcomes. Cox proportional hazards regression models were used to estimate the correlations, stratified subgroup analyses were used to figure out effect modifiers, and sensitivity analyses were used to confirm the robustness.</div></div><div><h3>Results</h3><div>A total of 22,729 NHANES participants were included in this study, with 6786 all-cause deaths, 1830 CVD deaths, and 1396 cancer deaths occurred during an average follow-up of 8.5 years over a total of 192,601 person-years. The hazard ratios (HRs) of delayed aging group for all-cause mortality, CVD mortality, and cancer mortality were 0.45 (95 % CI: 0.41–0.49), 0.39 (95 % CI: 0.34–0.45), and 0.54 (95 % CI: 0.46–0.63), respectively, compared to accelerated aging group (P for all comparisons &lt; 0.001). Likewise, the frailty index score was positively associated with all-cause mortality (HR, 1.06 [95 % CI, 1.06–1.06] per 0.01 increase in the frailty index), cardiovascular (CVD) mortality (HR, 1.07 [95 % CI, 1.06–1.07] per 0.01 increase in the frailty index), and cancer mortality (HR, 1.04 [95 % CI, 1.03–1.04] per 0.01 increase in the frailty index). The associations of frailty index with all-cause mortality and CVD mortality were modified by biological aging (P for interaction = 0.044), but cancer mortality was not (P for interaction = 0.482).</div></div><div><h3>Conclusions</h3><div>Accelerated biological aging is associated with higher frailty index, whereas delayed biological aging is inversely associated with risk of all-cause mortality, CVD mortality, and cancer mortality. Biological aging is effect modification among the associations of frailty index with all-cause mortality and CVD mortality, but not for cancer mortality. These findings suggest that for people with high frailty index and acceleration biological aging, to lower frailty degree and decrease biological aging acceleration by approaches such as lifestyle modifications might be beneficial for individual's longevity and lifespan.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105856"},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient healthcare utilization among formerly married adults in India: Evidence from the Longitudinal Ageing Study in India (LASI-1)","authors":"Saurabh Singh,&nbsp;Akancha Singh,&nbsp;Neha Shri","doi":"10.1016/j.archger.2025.105859","DOIUrl":"10.1016/j.archger.2025.105859","url":null,"abstract":"<div><div>India has been on the brink of rapid socio-economic changes and these changes have manifested themselves through improvements in health and overall living standards of the general population. Although several health strategies and policies have addressed the equitable distribution of health care in India, not many studies have been undertaken on this topic, especially among formerly married older adults. The aim of this paper is to evaluate income related-inequalities in healthcare utilization among formerly married older population in India. This study utilizes individual level data from the first wave of the Longitudinal Ageing Study in India. Logistic regression was employed to examine the effect of the socio-economic characteristics on the health seeking behavior of the formerly married older adult population. The magnitude of socio-economic inequity in health care utilization was quantified using Wagstaff decomposition analysis. The regression results revealed that with higher levels of education, the odds of getting inpatient health care utilization decreased. For instance, the health care utilization was 32 % less among individuals with 10+ years of schooling than those who did not have any formal level of education [OR: 0.68; 95 % C.I.:0.52–0.88]. The odds of inpatient health care utilization was higher among those who had morbidity [one morbidity, OR:1.98; 95 % C.I.:1.68–2.36 &amp; multimorbidity OR: 2.68; 95 % C.I.:2.25–3.20]. Additionally, presence of multi-morbidity (83 %) and geographical regions (50 %) were two of the largest contributors to inequality in healthcare utilization. Findings from the current study point towards the need for having improved social security systems in place to protect the households from distress financing and reducing inequalities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105859"},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-treatment-induced accelerated aging in older adult cancer survivors: A call for actions for future perspectives in geriatric oncology","authors":"Médéa Locquet (epidemiologist)","doi":"10.1016/j.archger.2025.105858","DOIUrl":"10.1016/j.archger.2025.105858","url":null,"abstract":"<div><div>Cancer treatment has significantly improved survival rates, but older adult cancer survivors remain at risk of cancer-treatment-induced late effects such as cardiac complications and second primary cancers. A new hypothesis emerged in the literature suggesting that such late effects can indeed be the manifestation of an accelerated aging process induced by cancer treatments. The cancer-treatment-induced accelerated aging could first arise from clinical and biological manifestations such as frailty, sarcopenia, cognitive impairments, cellular senescence, telomere attrition, and chronic inflammation, paralleling hallmarks of aging. Older adult cancer survivors frequently demonstrated early-onset frailty, sarcopenia, osteoporosis, cognitive impairments, diminished physical function, and increased levels of aging biomarkers compared to cancer-free age-matched older adults. However, existing studies are limited by their narrow focus on specific cancers, the use of single aging outcome measures, and short follow-up durations. A holistic research approach, incorporating comprehensive geriatric assessments and aging biomarkers, is crucial for describing the induced health burden and the mechanisms underlying these induced aging vulnerabilities. Addressing these gaps through large-scale longitudinal studies could lead to personalized interventions, improved treatment protocols, and supportive care strategies in older adult cancer survivors. Such efforts will enhance quality of life, promote healthy aging trajectories, and mitigate societal and economic burdens. To this end, concrete actions, such as establishing international consortia that include patient advocacy, are encouraged. Efforts should also include developing a centralized, registry-based repository for clinical and biological aging outcomes.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105858"},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, validation, and clinical utility of a risk prediction model to identify older women with dementia for proactive palliative care","authors":"Begashaw Melaku Gebresillassie ,&nbsp;John Attia ,&nbsp;Dominic Cavenagh ,&nbsp;Melissa L. Harris","doi":"10.1016/j.archger.2025.105853","DOIUrl":"10.1016/j.archger.2025.105853","url":null,"abstract":"<div><h3>Background</h3><div>Accurately estimating one-year mortality risk in older women with dementia can inform clinical decision-making, facilitate timely advanced care planning, and optimise palliative care delivery. This study aimed to develop, validate, and assess the clinical utility of a prediction model for one-year all-cause mortality in this population using a nationally representative Australian cohort.</div></div><div><h3>Methods</h3><div>This prognostic study utilised data from the 1921–26 cohort of the nationally representative, population-based Australian Longitudinal Study on Women's Health (ALSWH) and linked national and state-based administrative health records. Candidate predictors were identified through a systematic review and expert consultation, then refined using a data-driven statistical approach. A multivariable binary logistic regression model was developed and validated to predict one-year all-cause mortality.</div></div><div><h3>Results</h3><div>The analysis included 1576 older women with dementia (mean age, 72.6 ± 1.5 years). The model demonstrated good discrimination (AUC: 75.1 %, 95 % CI: 72.7 %–77.5 %) and excellent calibration (slope = 1.00, 95 % CI: 0.87–1.13; intercept = 0.00, 95 % CI: 0.11 – 0.11). Model validation using both 10-fold cross-validation and 1000 bootstrap iterations showed minimal optimism in its predictive performance, with AUC optimism of 0.0047 and 0.0042, respectively. Decision curve analysis indicated a net benefit across probability thresholds from 0.24 to 0.88, supporting the model's clinical utility for guiding palliative care decisions.</div></div><div><h3>Conclusion</h3><div>This prediction model, incorporating readily available predictors, demonstrated compelling performance and clinical utility for identifying older women with dementia at high risk of one-year mortality. The model has the potential to facilitate timely palliative care interventions and is publicly accessible via a web-based calculator. Further external validation in diverse populations and healthcare settings is warranted to confirm its generalisability.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105853"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory symptoms in preserved ratio impaired spirometry: Link to comorbidities and increased mortality risk","authors":"Ping Lin ,&nbsp;Faming Jiang ,&nbsp;Yu Wang,&nbsp;Zongan Liang,&nbsp;Ting Wang","doi":"10.1016/j.archger.2025.105855","DOIUrl":"10.1016/j.archger.2025.105855","url":null,"abstract":"<div><h3>Backgroundx</h3><div>Respiratory symptoms are frequently observed in subjects with Preserved Ratio Impaired Spirometry (PRISm); however, their association with comorbidities and mortality in this population remains poorly understood.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (2007–2012) were analyzed. Logistic regression was used to assess the association between respiratory symptoms and comorbidities, while Cox regression was applied to evaluate mortality risks.</div></div><div><h3>Results</h3><div>This study included 5612 adults aged 40 years and older with normal spirometry and 754 participants with PRISm. Among the PRISm group, 331 subjects (43.8 %) reported one or more respiratory symptoms. Compared to individuals with normal spirometry, PRISm subjects with respiratory symptoms exhibited a significantly higher prevalence of comorbidities, including hypertension, diabetes, angina, myocardial infarction, heart failure, and stroke, as well as increased risks of all-cause and cardiovascular mortality. In contrast, PRISm without respiratory symptoms was primarily associated with diabetes and an elevated mortality risk. When comparing PRISm subjects with and without respiratory symptoms, those with symptoms had a markedly higher prevalence of hypertension (OR 1.10, 95 % CI: 1.08–1.11), myocardial infarction (OR 5.75, 95 % CI: 2.25–14.67), heart failure (OR 5.52, 95 % CI: 2.50–12.19), and cancer (OR 2.34, 95 % CI: 1.12–4.86). Additionally, PRISm subjects with respiratory symptoms faced a significantly elevated risk of cardiovascular mortality (HR 1.55, 95 % CI: 1.38–1.74).</div></div><div><h3>Conclusions</h3><div>Respiratory symptoms were associated with a significantly higher burden of comorbidities and an increased risk of cardiovascular mortality in PRISm subjects.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105855"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding physical aging in relation to biological aging, telomere length: A systematic review","authors":"Kyi Mar Wai ,&nbsp;Arkar Min Paing ,&nbsp;Thinzar Swe","doi":"10.1016/j.archger.2025.105854","DOIUrl":"10.1016/j.archger.2025.105854","url":null,"abstract":"<div><h3>Background</h3><div>Telomere length (TL) serves as a marker for biological aging, influenced by chronological aging but distinct from it. This systematic review aims to synthesize the evidence on the associations between components of physical aging and TL in the elderly population.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in online databases of PubMed, Web of Science, ProQuest, and ScienceDirect to identify the eligible papers published until 1st August 2024. The authors independently extracted data using the standardized form. The quality of the included studies was evaluated for the risks of biases.</div></div><div><h3>Results</h3><div>A total of 1080 records were initially identified using the predefined search strategy. A total of 40 eligible records were included in this review. When assessing physical aging, the nature and type of measurements across studies vary, including subjective, objective, and a combination of both approaches. Subjective assessments of general health or physical limitations may be linked with TL, while frailty, whether measured subjectively or objectively, shows associations with TL in less than 35 percent of total studies. In contrast, composite measures of physical performance/ability are consistently associated with TL in the elderly population.</div></div><div><h3>Conclusions</h3><div>In conclusion, we demonstrated that the associations between physical aging and TL varies depending on the type and nature of physical aging assessments. Composite measures of physical performance/ability demonstrate a strong and consistent parameter of physical aging to link with TL. Future research should prioritize standardized, multidimensional approaches to measure physical aging to understand better its association with TL to support healthy aging strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105854"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wakefulness after sleep offset and the elevated risk of mortality in older adults with evening preferences: A community-based 5-year longitudinal study","authors":"Georg von Fingerhut,&nbsp;Keitaro Makino,&nbsp;Osamu Katayama,&nbsp;Ryo Yamaguchi,&nbsp;Daiki Yamagiwa,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2025.105852","DOIUrl":"10.1016/j.archger.2025.105852","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>This study investigated the relationship between wakefulness after sleep offset timing (WASF), evening chronotype preferences, and mortality risk in community-dwelling older adults.</div></div><div><h3>Research design and methods</h3><div>We conducted a community-based longitudinal study with a sample of 4167 older adults aged ≥60. The sleep characteristics, WASF, subjective chronotype preferences, and other relevant variables of the participants at baseline were evaluated. We examined the association between WASF and mortality over a 5-year period using Cox proportional hazards models, with stratification by subjective chronotype preferences to explore potential effect modification.</div></div><div><h3>Results</h3><div>Data from 3734 participants were analyzed (71.1 ± 6.9 years; 2114 [56.6 %] women). The 5-year mortality incidence was 6.3 %. Overall, participants had a median (IQR) of 5.0 (2–20) min WASF, and 767 (20.6 %) were evening types. WASF of ≤5 min = 10.6 (95 % CI, 8.9–12.8), WASF of &gt;5 min = 14.6 (95 % CI, 12.1–17.6). The mortality incidence rates per 1000 person-years were: WASF of ≤5 min = 10.6 (95 % CI, 8.9–12.8) and WASF of &gt;5 min = 14.6 (95 % CI, 12.1–17.6). Even after adjusting for covariates, the longer WASF participants had a higher hazard ratio of 1.40 (95 % CI, 1.04–1.88) compared to the shorter WASF participants. Regular, prolonged WASF was found to be significantly associated with an increased risk of mortality among evening-type individuals (2.69; 95 % CI: 1.19–6.08) in the stratified model based on subjective chronotype preferences. However, we found no statistically significant association among the other types.</div></div><div><h3>Discussion and implications</h3><div>Reducing morning time in bed, and addressing prolonged WASF are crucial factors in decreasing mortality risk among older adults, especially among those with evening preferences.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105852"},"PeriodicalIF":3.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clearing the confounding confusion: Benzodiazepines and the risk of dementia?","authors":"Kevin J Friesen ,&nbsp;Jamie Falk ,&nbsp;I Fan Kuo ,&nbsp;Alexander Singer ,&nbsp;Shawn Bugden","doi":"10.1016/j.archger.2025.105850","DOIUrl":"10.1016/j.archger.2025.105850","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the relationship between duration of benzodiazepine exposure and the risk of dementia.</div></div><div><h3>Design</h3><div>A retrospective cohort study using administrative health data followed 3 age-based strata (ages 55, 65 and 75) for up to a maximum of 22 years to examine risk of dementia due to benzodiazepine use. Each stratum was analyzed as a whole, then restricted to persons with depression or anxiety, and finally using high dimension propensity scores (HDPS) matched cohort.</div></div><div><h3>Setting</h3><div>We used administrative data on subjects receiving standard medical care in Manitoba, Canada.</div></div><div><h3>Measurements</h3><div>Prescription data was used to quantify benzodiazepine using cumulative defined-daily-dose (DDD). Comorbidities and cases of dementia were determined using medical and hospital data.</div></div><div><h3>Results</h3><div>Dementia risk in high-dose users of the youngest strata was elevated compared to non-users (adjusted HR (aHR) 1.33; 95 % CI 1.05–1.68)). Little to no difference was found in the middle (aHR 1.17; 1.02–1.33) and oldest strata (aHR 1.02; 0.93–1.11). Restriction to persons with depression or anxiety eliminated the association. No association was found using HDPS-matched comparison groups.</div></div><div><h3>Conclusions</h3><div>Only a modest increase in dementia risk was seen in the high-dose benzodiazepine users. This association appears to be driven by the confounding due to higher rates of diabetes, cardiovascular disease, depression, and anxiety among users. Using restriction or HDPS to better control for confounding effects eliminates the association. While benzodiazepines do not appear to be a significant risk factor for dementia, tolerance, dependency and adverse effects caution against their long-term use.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105850"},"PeriodicalIF":3.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effects of Otago Exercise Program and Aquatic Exercise on Fall Risk in Older Adults: A Systematic Review”. [Archives of Gerontology and Geriatrics, 2025: 105799.]","authors":"Mingyuan Dong ,&nbsp;Xi Liu ,&nbsp;Yongchul Choi ,&nbsp;Ning Li","doi":"10.1016/j.archger.2025.105838","DOIUrl":"10.1016/j.archger.2025.105838","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105838"},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}