Archives of gerontology and geriatrics最新文献

{"title":"Service robots in caring for older adults: Uncovering the current conceptual and intellectual structures and future research agenda","authors":"Larissa C Cesário ,&nbsp;Priscila Barbosa ,&nbsp;Paulo Augusto Cauchick Miguel ,&nbsp;Glauco H.S. Mendes","doi":"10.1016/j.archger.2025.105755","DOIUrl":"10.1016/j.archger.2025.105755","url":null,"abstract":"<div><div>Service robots have supported human activity, mainly caring for older adults, for many years. However, a new generation of service robots empowered by artificial intelligence and other novel technologies indicates an increasing use of service robots in our society. Thus, this article aims to synthesize and integrate current research on service robots in caring for older adults, identifying its conceptual and intellectual structures and future research opportunities. A total of 390 articles ranging from the year 1997 to 2022 were analyzed with text-mining and visualization methods. We found that this research is composed of six main themes: (i) acceptance and design of robots; (ii) social role and ethical values (iii) obstacles and criticism; (iv) effects, effectiveness, and impact of using robots; (v) therapeutic use of robots and (vi) perceptions of health professionals and services. We also identified future research opportunities which researchers can use to advance the topics of this research. Identifying research clusters and key works in this multidisciplinary research field can assist researchers in understanding the current status of this research and, after that, better positioning their studies and finding avenues to move forward with the use of service robots for caring for older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105755"},"PeriodicalIF":3.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty and subjective life expectancy in Sub-Saharan Africa: Evidence from Côte D'Ivoire","authors":"Gideon Dzando ,&nbsp;Richard K. Moussa","doi":"10.1016/j.archger.2025.105757","DOIUrl":"10.1016/j.archger.2025.105757","url":null,"abstract":"<div><h3>Aim</h3><div>Frailty and Subjective Life Expectancy are important determinants of the health and well-being of older adults. This study aims to investigate the relationship between frailty and Subjective Life Expectancy in Sub-Sahara Africa.</div></div><div><h3>Methods</h3><div>This study is a cross-sectional study involving 1,017 older adults aged 50 years and above across three regions of Côte d'Ivoire. A 30-item Frailty Index was used to determine the prevalence of frailty. Subjective Life Expectancy was measured using self-reported estimates of expected lifespan. The point estimate and probabilistic procedures were used, with target ages set at 60, 80, 85, and 90 years. A non-parametric estimation procedure was used to compute the average life expectancy at individual level based on data from the probabilistic procedure. The distributional effects of frailty on Subjective Life Expectancy were assessed with the quantile selection model.</div></div><div><h3>Results</h3><div>The results indicate that, more than half (59.3 %) of the study participants were frail, 24.6 % were pre-frail and 16.1 % were non-frail. Being frail was negatively associated with Subjective Life Expectancy. Frail individuals had up to 3.7 years lower Subjective Life Expectancy compared to the non-frail individuals. Compared to individuals aged 50–54, those aged 55–59 and 80+ years had 4.8 and 27.8 years lower Subjective Life Expectancy respectively.</div></div><div><h3>Conclusion</h3><div>The study demonstrates a close connection between frailty and Subjective Life Expectancy among older adults, suggesting that interventions aimed at preventing or reducing frailty can influence Subjective Life Expectancy and overall well-being.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105757"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particulate matter, socioeconomic status, and cognitive function among older adults in China","authors":"Qi Zhao","doi":"10.1016/j.archger.2025.105756","DOIUrl":"10.1016/j.archger.2025.105756","url":null,"abstract":"<div><h3>Background</h3><div>Both air pollution and low socioeconomic status (SES) are associated with worse cognitive function. The extent to which low SES may compound the adverse effect of air pollution on cognitive function remains unclear.</div></div><div><h3>Methods</h3><div>7,087 older adults aged 65 and above were included from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and followed up in 4 waves during 2008–2018. Cognitive function was measured repeatedly at each wave using the modified Chinese Mini-Mental State Examination (MMSE). Concentrations of particulate matter (PM₁, PM_2.5, and PM₁₀) were evaluated using satellite-based spatiotemporal models. SES was measured based on five components and categorized into three levels (low, middle, and high). Generalized estimating equation models were used to estimate the association of PM and SES with cognitive function. Stratified analyses and effect modification by SES levels were further conducted.</div></div><div><h3>Results</h3><div>Each 10 µg/m³ increase in PM₁, PM_2.5, and PM₁₀ was associated with a 0.43 (95 % CI: -0.58, -0.27), 0.29 (95% CI: -0.37, -0.20), and 0.17 (95 % CI: -0.22, -0.13) unit decrease in MMSE scores, respectively. Lower SES was associated with worse cognitive function. Significant effect modifications were observed by SES, with the corresponding association of PM exposure being more pronounced among participants with a lower SES (p-interaction = 0.006, 0.001, and 0.006 for PM₁, PM_2.5, and PM₁₀, respectively).</div></div><div><h3>Conclusions</h3><div>SES is an important effect modifier, and lower SES may compound the detrimental effect of PM on cognitive health. This finding may have implications for identifying vulnerable populations and targeted interventions against air pollution.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105756"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic performance of phase angle for sarcopenia among older adults: A systematic review and diagnostic meta-analysis","authors":"Shuanglong Hou ,&nbsp;Xin Zhao ,&nbsp;Jiaxin Wei ,&nbsp;Gang Wang","doi":"10.1016/j.archger.2025.105754","DOIUrl":"10.1016/j.archger.2025.105754","url":null,"abstract":"<div><h3>Objective</h3><div>Phase angle is a promising tool for diagnosing sarcopenia. This study aimed to summarize its diagnostic performance by performing a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of PubMed, Web of Science, Embase, and Scopus. The Quality Assessment of Diagnostic Accuracy Studies, Version 2, was used to evaluate the quality of the studies. A bivariate random effects model was employed for data synthesis, and diagnostic performance was reported in terms of pooled sensitivity, specificity, and the area under the summary receiver operating characteristic curve (AUC). Additionally, meta-regression, subgroup analyses, and sensitivity analyses were performed.</div></div><div><h3>Results</h3><div>A total of 15 studies were included in this meta-analysis, involving 4,063 participants. The overall risk of bias in the included studies was high. The meta-analysis revealed that the pooled sensitivity and specificity across all studies were 0.74 [95 % confidence interval (CI): 0.71–0.78] and 0.75 (95 % CI: 0.70–0.79), respectively, with an AUC of 0.79 (95 % CI: 0.76–0.83). Meta-regression indicated that study design, country, population, sex-specificity, and age may influence the diagnostic performance of phase angle. The optimal diagnostic performance was observed in the cut-off interval of 4.20 to 4.50°.</div></div><div><h3>Conclusion</h3><div>The phase angle demonstrated moderate diagnostic performance for sarcopenia, and the possible cut-off interval is 4.20 to 4.50 °. However, large-scale, multicenter prospective studies are necessary to assess its clinical applicability at specific cut-off values.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105754"},"PeriodicalIF":3.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effects of social isolation and loneliness on disability incidence in older adults","authors":"Hiroyuki Shimada ,&nbsp;Takehiko Doi ,&nbsp;Kota Tsutsumimoto ,&nbsp;Keitaro Makino ,&nbsp;Kenji Harada ,&nbsp;Kouki Tomida ,&nbsp;Masanori Morikawa ,&nbsp;Hidenori Arai","doi":"10.1016/j.archger.2025.105749","DOIUrl":"10.1016/j.archger.2025.105749","url":null,"abstract":"<div><h3>Objectives</h3><div>Relationships among social isolation, loneliness, and disability onset remain unclear. We investigated the distinct patterns of disability development among Japanese older adults who experience social isolation and loneliness.</div></div><div><h3>Design</h3><div>This study applied a prospective observational approach.</div></div><div><h3>Participants</h3><div>Data from 4,716 community-dwelling independent older adults were analyzed.</div></div><div><h3>Measurements</h3><div>The Japanese version of the University of California, Los Angeles Loneliness Scale Version 3 and the Social Isolation Scale were used to measure loneliness and social isolation, respectively. The long-term care insurer conducted monthly follow-ups with participants over two years to determine their care needs. Disability onset was defined as the point at which participants were certified by a care manager as requiring long-term care.</div></div><div><h3>Results</h3><div>During the follow-up period, 265 participants (5.6 %) required long-term care insurance certification due to disability onset. The incidence of disability in the lonely and not lonely groups was 8.0 % and 4.5 %, respectively. In the socially isolated and not socially isolated groups, it was 7.1 % and 4.4 %, respectively. The Cox proportional hazards regression model revealed a significantly higher risk of disability incidence in the lonely and socially isolated groups. The high-risk group experiencing both loneliness and social isolation exhibited significantly higher hazard ratios than the low-risk group without these symptoms.</div></div><div><h3>Conclusions</h3><div>The results indicated that older adults experiencing both social isolation and loneliness were at high-risk for future disability incidence. This finding provides insight into the complex interplay between social factors and disability, which can contribute to the development of effective interventions to promote healthy aging and prevent disability.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105749"},"PeriodicalIF":3.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury","authors":"Lichao Ling ,&nbsp;Guoyang Zhou ,&nbsp;Xun Zhang ,&nbsp;Baojie Mao ,&nbsp;Shu Wan ,&nbsp;Yizhong Bao","doi":"10.1016/j.archger.2024.105739","DOIUrl":"10.1016/j.archger.2024.105739","url":null,"abstract":"<div><div>Ischemic stroke, a severe cerebrovascular disease, is particularly prevalent among the elderly. Rsearch has indicated that histone deacetylases (HDACs) are pivotal in the pathogenesis of ischemic stroke. We introduce a novel HDACs inhibitor, HDI-1, as a potential therapeutic strategy for this condition. Our study reveals that HDI-1 expedites the restoration of tight junction proteins, Occludin and Claudin-5, in the oxygen-glucose deprivation/reoxygenation (OGD/R) model using human cerebral microvascular endothelial cells (hCMEC/D3). Moreover, HDI-1 mitigates the impairment of cellular monolayer membrane permeability following injury. This effect may stem from HDI-1′s ability to selectively suppress the enzymatic activity of HDAC2. By inhibiting the activation of the NF-κB pathway triggered by OGD/R injury, HDI-1 reduces the secretion of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α, thereby diminishing the inflammatory response in hCMEC/D3 cells. Meanwhile, HDI-1 exhibits antioxidant properties by enhancing the Nrf2/HO-1 signaling pathway. Collectively, our findings propose HDI-1 as a promising candidate for ischemic stroke treatment.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105739"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-management interventions for men with lower urinary tract symptoms: A systematic review and meta-analysis of randomized controlled trials","authors":"Akash Kumar ,&nbsp;Hamza Ashraf ,&nbsp;Priyanka Keshav Lal ,&nbsp;Rubyisha Sheikh ,&nbsp;Shanzay Akhtar ,&nbsp;Ahsan Raza Raja ,&nbsp;Ibrahim Nagm ,&nbsp;Ram ,&nbsp;Haider Ashfaq","doi":"10.1016/j.archger.2024.105742","DOIUrl":"10.1016/j.archger.2024.105742","url":null,"abstract":"<div><h3>Introduction</h3><div>Lower urinary tract symptoms (LUTS) significantly impact men's quality of life and can cause bothersome symptoms, which often interfere with daily functioning and contribute to psychological distress. While pharmacological and surgical treatments are effective, they can have side effects, and not all men require or desire these interventions. The aim of this study is to assess the impact of self-management interventions on symptom severity.</div></div><div><h3>Methods</h3><div>We conducted a systematic search across multiple databases, including PubMed, Embase, and Cochrane Library, from inception to August 2024. We identified randomized controlled trials (RCTs) assessing self-management interventions for LUTS in men. Studies were evaluated for quality and analyzed for outcomes on BPH Impact Index, International Prostate Symptom Score (IPSS), and QoL. Publication bias and heterogeneity were examined through LFK indices, sensitivity analyses, and Doi plots.</div></div><div><h3>Results</h3><div>Self-management significantly reduced the BPH Impact Index at 3 months (SMD: -0.73; <em>p</em> = 0.0003) and 6 months (SMD: -0.95; <em>p</em> = 0.05), though publication bias was indicated. The IPSS decreased significantly at 3 months (MD: -5.52; <em>p</em> &lt; 0.01), 6 months (MD: -5.50; <em>p</em> = 0.002), and 12 months (MD: -3.51; <em>p</em> = 0.01). Quality of life also improved at 6 and 12 months (SMD: -0.34, <em>p</em> = 0.002, and SMD: -0.30, <em>p</em> &lt; 0.01, respectively). Sensitivity analysis confirmed the consistency of these findings after adjusting for study heterogeneity.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that self-management interventions provide a significant benefit in reducing LUTS severity and enhancing quality of life in men.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105742"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of exercise training protocols on blood pressures and lipid profiles in older adults patients with hypertension: A systematic review and meta-analysis","authors":"Keyvan Hejazi ,&nbsp;Zahra Ataran Iraj ,&nbsp;Ayoub Saeidi ,&nbsp;Anthony C. Hackney ,&nbsp;Fatiha Laziri ,&nbsp;Katsuhuko Suzuki ,&nbsp;Ismail Laher ,&nbsp;Zouhal Hassane","doi":"10.1016/j.archger.2024.105737","DOIUrl":"10.1016/j.archger.2024.105737","url":null,"abstract":"<div><div>Decreased physical activity and high blood pressure are both risk factors for cardiovascular diseases. Controlling blood pressure within the normal range can prevent or delay these complications. This systematic review and meta-analysis analyzed the effects of different types of exercise training on the blood pressure and lipid profiles of older adults patients with hypertension. Five electronic databases (Web of Science, Cochrane, PubMed, Google Scholar, and Scopus) were searched from their inception until March 03, 2024. English publications and randomized controlled trials involving different types of exercise training treatments for hypertensive populations were included. Data were analyzed using a random-effects model to estimate weighted mean differences (WMD) and 95 % confidence intervals. The systematic search identified 1998 articles, of which 92 studies met the inclusion criteria and were deemed eligible for inclusion. The results of the meta‐analysis indicated that reduced systolic (SBP) and diastolic blood pressures (DBP) after aerobic training (<em>p &lt;</em> 0.01), resistance training (<em>p &lt;</em> 0.01), combined (aerobic + resistance) exercise training (<em>p &lt;</em> 0.01) and isometric handgrip training (<em>p &lt;</em> 0.01). Significant reductions were also observed in low-density lipoprotein (LDL) and triglyceride (TG) levels following combined (aerobic + resistance) exercise training (<em>p &lt;</em> 0.05 and <em>p &lt;</em> 0.001), and resistance training (<em>p &lt;</em> 0.01), respectively. High-density lipoprotein (HDL) levels were increased following aerobic training (<em>p &lt;</em> 0.01), and combined (aerobic + resistance) exercise training (<em>p &lt;</em> 0.01), but not after resistance and Tai chi training. Isometric handgrip training leads to greater reductions in blood pressure in hypertensive patients compared to the effects of aerobic, resistance, combined aerobic and resistance exercise, and tai chi training. Additional studies are needed to determine the exercise prescription protocols to maximize the health of older adults patients with hypertension.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105737"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional longitudinal associations between subjective oral health and subjective well-being","authors":"Taro Kusama ,&nbsp;Takamasa Komiyama ,&nbsp;Kenji Takeuchi ,&nbsp;Wael Sabbah ,&nbsp;Ken Osaka ,&nbsp;Jennifer E Gallagher","doi":"10.1016/j.archger.2024.105740","DOIUrl":"10.1016/j.archger.2024.105740","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the bidirectional longitudinal association between subjective oral health (SOH) and subjective well-being (SWB) over time.</div></div><div><h3>Methods</h3><div>This cohort study was based on a four-wave surveys conducted by the English Longitudinal Study of Aging. SOH was measured by oral impacts on daily performance (OIDP), self-rated oral health (SROH), and SWB was measured by the Center for Epidemiologic Studies-Depression (CES-D) scale, Control, Autonomy, Self-Realization, and Pleasure (CASP-19), and satisfaction with life scale (SWLS). To evaluate the bidirectional associations between SOH and SWB, separate models were created using SOH and SWB as the outcome and exposure, respectively. Additionally, the synchronous and lagged effects of exposure on outcomes were checked by employing exposures measured at different time points. A generalized estimating equation model was fitted, including the exposure variables, outcome variables in the previous wave, and baseline covariates.</div></div><div><h3>Results</h3><div>Among 4,510 participants (mean age=61.7 years [1SD=7.9], men=43.1 %), 8.1 %, 18.2 %, 14.3 %, 30.5 %, and 25.0 % had poor SOH and SWB as measured by OIDP, SROH, CES-D, CASP-19, and SWLS at baseline, respectively. The results of the regression models with all combinations of SOH and SWB measures showed that poor conditions of SOH or SWB were significantly associated with poor conditions of the other measures (all p &lt; 0.05). In almost all combinations of SOH and SWB measures, the synchronous effect was stronger than the lagged effect.</div></div><div><h3>Conclusion</h3><div>SOH and SWB are closely linked, and comprehensive care that considers oral health could contribute to well-being later in life.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105740"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesencephalic astrocyte-derived neurotrophic factor inhibits neuroinflammation through autophagy-mediated α-synuclein degradation","authors":"Kai-Ge Zhou ,&nbsp;Yi-Bin Huang ,&nbsp;Zi-Wen Zhu ,&nbsp;Ming Jiang ,&nbsp;Ling-Jing Jin ,&nbsp;Qiang Guan ,&nbsp;Lu-Lu Tian ,&nbsp;Jing-Xing Zhang","doi":"10.1016/j.archger.2024.105738","DOIUrl":"10.1016/j.archger.2024.105738","url":null,"abstract":"<div><div>Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder marked by the progressive loss of dopamine neurons in the substantia nigra. α-synuclein (SNCA) aggregation-induced microglia activation and neuroinflammation play vital role in the pathology of PD. Our previous studies showed that mesencephalic astrocyte-derived neurotrophic factor (MANF) could inhibit SNCA accumulation and Lipopolysaccharides (LPS)-induced neuroinflammation, but the specific molecular mechanism remains unclear. In this study, we showed that knock-down the expression of MANF leads to the up-regulation of inflammatory factor tumor necrosis factor-α (TNF-α). Exogenous MANF protein inhibits LPS-induced neuroinflammation in BV2 cells. Additionally, our results indicated that knock-down of the expression of MANF triggered autophagic pathway dysfunction, while exogenous addition of MANF protein or using adeno-associated virus 8 (AAV8) mediated MANF over-expression could activate the autophagic system and subsequently suppress SNCA accumulation. Furthermore, using autophagy inhibitor to block autophagic flux, we found that MANF prevented neuroinflammation by autophagy-mediated SNCA degradation. Collectively, this study indicated that MANF has potential therapeutic value for PD. Autophagy and its role in MANF-mediated anti-inflammatory properties may provide new sights that target SNCA pathology in PD.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105738"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}