Archives of gerontology and geriatrics最新文献

{"title":"Effects of Otago Exercise Program and aquatic exercise on fall risk in older adults: A systematic review","authors":"Mingyuan Dong ,&nbsp;Xi Liu ,&nbsp;Yongchul Choi ,&nbsp;Ning Li","doi":"10.1016/j.archger.2025.105799","DOIUrl":"10.1016/j.archger.2025.105799","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this systematic review was to determine the processes and forms of participation in Otago Exercise Program (OEP) and Aquatic exercise(AE) for the prevention of falls in older adults, and to compare the effectiveness of the two exercises as interventions for the prevention of falls in older adults.</div></div><div><h3>Methods</h3><div>Using electronic databases such as PubMed, Web of Science, Embase, Scopus, and Google Scholar, we searched for relevant domestic and foreign papers in the last 15 years, and evaluated the methodology and quality of the report by both AMSTAR 2 and PRISMA scales to evaluate the methodology and reporting quality.</div></div><div><h3>Results</h3><div>A total of 33 papers were included by searching various literatures related to the topic of this study and carefully reviewed by the researcher.</div></div><div><h3>Conclusion</h3><div>This systematic review confirms that OEP and AE effectively prevent falls in older adults by improving cognitive function, lower limb muscle strength, and balance. OEP significantly enhances muscle strength, while AE shows slight superiority in improving balance-related abilities like gait stability. These findings highlight the need for optimized training cycles in OEP and AE to maximize muscle adaptation. Both programs are safe and effective, with potential to reduce falls and enhance physical and cognitive functions. Tailored interventions, aligned with home health care guidelines and specific living environments, can improve quality of life. Future research should explore the optimal exercise modalities and intensities, and conduct longitudinal studies to assess long-term outcomes, particularly for older adults with specific health conditions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105799"},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary indices to measure diet quality in older cancer survivors: A scoping review on tools, their components and association with health outcomes","authors":"Andrea Boehmer ,&nbsp;Christina Syu Hong Thio ,&nbsp;Juliana Christina ,&nbsp;Michelle Miller ,&nbsp;Alex Fauer ,&nbsp;Elsa Dent ,&nbsp;Wendy Wing Tak Lam ,&nbsp;Danielle Wing Lam Ng ,&nbsp;Raymond Javan Chan ,&nbsp;Chad Yixian Han","doi":"10.1016/j.archger.2025.105797","DOIUrl":"10.1016/j.archger.2025.105797","url":null,"abstract":"<div><h3>Background</h3><div>Older cancer survivors live with more comorbidities and have a higher mortality rate compared to the general older population. A high-quality diet that adheres to evidence based dietary recommendations and guidelines may help mitigate these issues. This can be assessed using dietary quality indices (DQIs), which objectively summarize scores for selected dietary components.</div></div><div><h3>Objective</h3><div>Identify the DQIs available in the literature for older cancer survivors, and their associations with health outcomes.</div></div><div><h3>Method</h3><div>Five databases were searched to identify peer-reviewed articles in English, from inception to 12th November 2024. Two researchers independently screened 3,145 studies, extracted and qualitatively assessed data from 28 included reports from 16 studies.</div></div><div><h3>Results</h3><div>12 DQIs and 40 unique components within these indices were identified and summarised narratively. Total vegetables (<em>n</em> = 8), total fruits (<em>n</em> = 8), whole grains (<em>n</em> = 6), saturated fat (<em>n</em> = 8), and salt/sodium (<em>n</em> = 8) were the most frequently incorporated components within a DQI. All DQIs were derived from evidence-based dietary guidelines. Only three DQIs were specifically designed for oncology population. Higher diet quality was associated with higher HR-QoL in breast, prostate, and colorectal cancer survivors in all but one study. The associations between mortality and diet quality were inconsistent, depending on the type of cancer and the mortality type i.e., cancer-specific or other causes.</div></div><div><h3>Conclusions</h3><div>DQIs are associated with important health outcomes. A major knowledge gap exists in DQIs suitable for older cancer survivors. Future research should develop DQIs to better assess how high-quality diets enhance health outcomes in older cancer survivors.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105797"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital reminiscence intervention program using a time-traveling road map for community-dwelling older adults with subjective cognitive decline","authors":"Yeon-Ha Kim ,&nbsp;Chung-Min Cho","doi":"10.1016/j.archger.2025.105789","DOIUrl":"10.1016/j.archger.2025.105789","url":null,"abstract":"<div><h3>Background</h3><div>Subjective cognitive decline (SCD) is a common concern among older adults in the South Korean population. Thus, non-pharmacological interventions are needed to reduce cognition, communication, and mood complaints.</div></div><div><h3>Objective</h3><div>This study evaluated the effects of a Roadmap Time-Traveling Intervention program (RMTI), a digital reminiscence therapy intervention, on cognitive measurements, communication, and mood in older adults with SCD.</div></div><div><h3>Methods</h3><div>Fifty participants were randomly assigned to the experimental or control group. Cognitive function, communication difficulties, quality of life (QoL), depression, and anxiety were assessed at baseline (T0), immediately after the intervention (T1), and four weeks post-intervention (T2). Generalized estimation equations were utilized to analyze the program's effectiveness over time (T0-T1) between groups. A repeated measures ANOVA and the Friedman/Wilcoxon signed-rank tests examined changes across the three time points (T0-T1-T2) within the experimental group. The study followed the Consolidated Standards of Reporting Trials guidelines.</div></div><div><h3>Results</h3><div>The experimental group exhibited significant improvements in the Korean version of the Mini-Mental State Examination (MMSE-K) scores (<em>p</em> &lt; .001) and QoL (<em>p</em> &lt; .001) compared with the control group: MMSE-K scores (Ⲭ² = 9.55, <em>p</em> = .008), communication difficulties (Ⲭ² = 8.57, <em>p</em> = .014), and QoL (Ⲭ² = 3.35, <em>p</em> = .046) improved significantly across the three time points (T0-T1-T2).</div></div><div><h3>Conclusions</h3><div>The RMTI effectively enhanced MMSE-K scores, reduced communication difficulties, and enhanced the QoL in older adults with SCD. This program shows promise for broader implementation in community settings for older adults with SCD.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105789"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of geriatric care on health outcomes in older patients with cardiac disease: A systematic review","authors":"Renee C.M.A. Raijmann ,&nbsp;Terésa N. van Dalen ,&nbsp;Huiberdina L. Koek ,&nbsp;Manon G. van der Meer ,&nbsp;Marielle H. Emmelot-Vonk ,&nbsp;Carolina J.P.W. Keijsers","doi":"10.1016/j.archger.2025.105786","DOIUrl":"10.1016/j.archger.2025.105786","url":null,"abstract":"<div><h3>Background</h3><div>As patients with cardiac disease age and become frail, their care needs become more complex. Therefore geriatric care might benefit these patients. This review summarizes current research investigating the impact of geriatric care on clinical outcomes in older cardiac patients.</div></div><div><h3>Methods</h3><div>The MEDLINE, Embase, and Cochrane databases were searched on 11 May 2023 for randomized controlled trials (RCTs) and observational studies comparing additional geriatric care to usual care in older (+70) cardiac patients. The Cochrane risk of bias tool and Robbins-E tool were used for quality assessment of RCTs and observational studies respectively. Data on mortality rates, readmissions, length of stay, complications, discharge destinations, functional outcomes, and quality of life (QoL) were extracted. Two authors independently selected studies, extracted data and assess study quality.</div></div><div><h3>Results</h3><div>Twelve articles involving 3531 patients (average age 73–85 years; 44–59 % male) were identified, mainly focussing on heart failure or patients requiring cardiothoracic surgery. The studies had a moderate to high risk of bias. Two out of three studies (<em>n</em> = 771) showed reduced complication rates (e.g. delirium incidence) when comparing geriatric assessment to usual care. Additionally, two out of three studies (<em>n</em> = 449), indicated improved QoL scores for patients who received a geriatric care. No significant effects were found for other outcomes.</div></div><div><h3>Conclusion</h3><div>Low-quality evidence suggests that geriatric care may be associated with lower complication rates and an improved quality of life in older cardiac patients. However, more research is needed to clarify the effect of a geriatric care in this patient population.</div></div><div><h3>Registration</h3><div>The study protocol was registered in the international prospective register of systematic reviews (PROSPERO 2022 CRD42022337353)</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105786"},"PeriodicalIF":3.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the protein-metabolite network of sarcopenia in plasma: A large-scale Mendelian randomization study","authors":"Wenhang Zuo,&nbsp;Jin Peng,&nbsp;Wen Guo,&nbsp;Jinhui Wu","doi":"10.1016/j.archger.2025.105788","DOIUrl":"10.1016/j.archger.2025.105788","url":null,"abstract":"<div><h3>Background</h3><div>Some plasma molecules may have an effect on sarcopenia, but it is not fully understood. We aimed to comprehensively explore the causal effects of plasma proteins and metabolites on sarcopenia traits, and to unravel their network.</div></div><div><h3>Methods</h3><div>A two-sample Mendelian randomization design was adopted. The levels of 4,907 plasma proteins from 35,559 Icelanders, and 1,400 plasma metabolites from 8,299 Europeans, were set as exposures. Low handgrip strength, appendicular lean mass, and usual walking pace from Europeans were set as outcomes. Inverse-variance weighted (IVW) and four other methods, along with sensitivity analyzes, were performed to estimate the causal effects. Enrichment and pathway analyzes were conducted to present their characteristics. IVW was used to estimate the bidirectional relationships between sarcopenia-related proteins and metabolites, and to visualize them within a network.</div></div><div><h3>Results</h3><div>We identified 76 relationships between proteins and sarcopenia traits. The absolute values of causal effects (β_IVW) ranging from 0.01 to 0.35. IL2, AIF1, GDNF, CXCL13, LRRTM3, and SLPI were the top six proteins ranked by causal effects. Additionally, 22 relationships between metabolites and sarcopenia traits were identified, with absolute values of β_IVW ranging from 0.02 to 0.22. Sulfate and serine/pyruvate ratio had the highest values. The network diagram showed some key nodes, such as ISOC1, GSTA1, tryptophan and 5α-androstan-3α,17β-diol monosulfate.</div></div><div><h3>Conclusions</h3><div>This work unraveled a molecular network of sarcopenia in plasma for the first time and identified some key proteins and metabolites. It may help to understand the mechanisms of sarcopenia, providing new insights for predicting, diagnosing and treating sarcopenia.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105788"},"PeriodicalIF":3.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between biological aging and cardiovascular health: Combined evidence based on cross-sectional and prospective study","authors":"Xiaoyi Zhu,&nbsp;Xinyi Wang,&nbsp;Xinling Tian,&nbsp;Yuzhe Kong","doi":"10.1016/j.archger.2025.105785","DOIUrl":"10.1016/j.archger.2025.105785","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the relationship between biological aging metrics and cardiovascular health, as well as the mediating effect of sleep duration.</div></div><div><h3>Method</h3><div>We applied the recommended sampling weights to adjust for the complex survey design of NHANES. Using NHANES data, we first employed restricted cubic spline (RCS) and logistic regression models to explore the cross-sectional associations between biological aging metrics, defined by the Klemera-Doubal method biological age (KDM-BA), phenotypic age (PA), homeostatic dysregulation (HD), and allostatic load (AL), and the prevalence of cardiovascular diseases (CVD) and its subtypes. We then used Cox regression, Kaplan-Meier curves, and RCS models to assess the prospective associations between biological aging metrics and all-cause as well as CVD mortality. Further, ROC and DCA models were used to assess the predicting ability of 4 biological aging metrics to cardiovascular health.</div></div><div><h3>Result</h3><div>This study included 7,704 participants. We found that biological aging metrics were strongly linked to the prevalence of CVD and its subtypes, as well as to all-cause and CVD mortality. Sleep duration appeared to moderate these associations. Among the four biological aging metrics, PA was the most effective predictor of CVD prevalence and its subtypes, though none of the metrics accurately predicted mortality.</div></div><div><h3>Conclusion</h3><div>Biological aging metrics were significantly associated with cardiovascular health, while sleep duration may attenuate this relationship. Clinically, PA can be a potential predictor of cardiovascular health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105785"},"PeriodicalIF":3.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein supplementation alone or combined with exercise for sarcopenia and physical frailty: A systematic review and meta-analysis of randomized controlled trials","authors":"Yoshihiro Yoshimura ,&nbsp;Ayaka Matsumoto ,&nbsp;Tatsuro Inoue ,&nbsp;Masatsugu Okamura ,&nbsp;Masafumi Kuzuya","doi":"10.1016/j.archger.2025.105783","DOIUrl":"10.1016/j.archger.2025.105783","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia and physical frailty are age-related syndromes characterized by progressive loss of muscle mass and function, significantly impacting mortality and quality of life in older adults. This systematic review evaluated the effectiveness of protein supplementation interventions for these conditions.</div></div><div><h3>Methods</h3><div>We systematically searched Medline, CENTRAL, and Ichushi Web from January 2000 to March 2023, with additional manual searching extended to March 2024. Randomized controlled trials investigating protein supplementation, alone or combined with exercise, in adults aged ≥65 years with sarcopenia or physical frailty were included. The primary outcomes were changes in muscle mass, strength, and physical performance.</div></div><div><h3>Results</h3><div>The systematic literature search identified 1,506 records through database searching (Medline: 357, CENTRAL: 275, Ichushi Web: 639) and 235 additional records through hand searching. Finally, 13 randomized controlled trials (n=1,057) met the inclusion criteria. Combined protein and exercise interventions demonstrated significant improvements in skeletal muscle index (MD = 0.89 kg/m², 95 % CI: 0.45 to 1.33) and handgrip strength (MD: +2.64 kg, 95 % CI: +0.75 to +4.53) compared to exercise alone. Protein supplementation alone showed modest benefits in muscle strength but limited effects on physical performance. No serious adverse events were reported.</div></div><div><h3>Conclusions</h3><div>While protein supplementation combined with exercise shows promising effects on muscle mass and strength in older adults with sarcopenia or physical frailty, the evidence quality was consistently rated as very low. Further high-quality trials are needed to establish optimal supplementation strategies.</div></div><div><h3>Registration</h3><div>PROSPERO: CRD42023408529</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105783"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis","authors":"Shenbi Yang ,&nbsp;Hongyan Wang ,&nbsp;Yanmin Tao ,&nbsp;Jing Tian ,&nbsp;Zhifei Wen ,&nbsp;Jun Cao ,&nbsp;Wen Zhang ,&nbsp;Sihan Peng ,&nbsp;Xiangeng Zhang","doi":"10.1016/j.archger.2025.105784","DOIUrl":"10.1016/j.archger.2025.105784","url":null,"abstract":"<div><h3>Purpose</h3><div>Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.</div></div><div><h3>Results</h3><div>A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; <em>I²</em> = 82 %, <em>p</em> &lt; 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; <em>I²</em> = 98 %, <em>p</em> &lt; 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.</div></div><div><h3>Conclusions</h3><div>No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105784"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A structural equation modeling approach to investigating the influence of smart kitchen appliance design features on older adults' technology acceptance","authors":"Yongchuan Li ,&nbsp;Cuiping Jiang ,&nbsp;Salwa Hanim Abdul-Rashid ,&nbsp;Raja Ariffin Raja Ghazilla ,&nbsp;Jing Jin","doi":"10.1016/j.archger.2025.105781","DOIUrl":"10.1016/j.archger.2025.105781","url":null,"abstract":"<div><div>This study investigates the influence of smart kitchen appliance design features on older adults' technology acceptance in China using the Smart Kitchen Appliance–Senior Technology Acceptance Model (SKA–STAM). The SKA–STAM extends the Technology Acceptance Model (TAM) with five key design elements: ergonomics, visuals, functions, interactive interfaces, and brands. A cross-sectional survey using a structured questionnaire was administered to 352 Chinese older adults aged 65–84 in first- and second-tier cities from August to October 2024. Participants were recruited through convenience sampling in residential areas, parks, and fitness spaces in Shanghai and Nanjing, and online random sampling in other cities. Structural equation modeling (SEM) was used to analyze the relationships between design elements, older adults' perceptions, and behavioral intention. The results support the significant role of ergonomics, functions, interactive interfaces, and brands in shaping older users' perceived usefulness, ease of use, and enjoyment. Perceived ease of use emerged as a critical mediator linking design elements to usefulness and enjoyment perceptions. The findings contribute to the theoretical understanding of technology acceptance among older adults and provide practical insights for designing senior-friendly smart kitchen appliances.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105781"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and pre-frailty prevalence in community-dwelling elderly with multimorbidity: A systematic review and meta-analysis","authors":"Shiying Cai ,&nbsp;Jue Li ,&nbsp;Yi Fang ,&nbsp;Zikai Feng ,&nbsp;Huanjiang Liu ,&nbsp;Jiaxin Chen ,&nbsp;Xiali Yang ,&nbsp;Bin Lin ,&nbsp;Zhiyuan Tian","doi":"10.1016/j.archger.2025.105782","DOIUrl":"10.1016/j.archger.2025.105782","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between frailty/pre-frailty, and multimorbidity in the elderly is recognized, but specific prevalence among community-dwelling elderly with multimorbidity is unclear. This study aims to determine these rates, analyze subgroup, and identify sources of heterogeneity to bolster evidence-based interventions and health policies.</div></div><div><h3>Methods</h3><div>We searched nine databases from inception to November 16, 2023, for cross-sectional and cohort studies on community-dwelling elderly with multimorbidity. Data were extracted to calculate the prevalence of frailty and pre-frailty. Study quality was assessed using AHRQ and NOS tools.</div></div><div><h3>Results</h3><div>Fifteen studies encompassing 9,683 participants with multimorbidity were analyzed. The pooled prevalence of frailty and pre-frailty was 18.1 % and 48.9 %, respectively. Age-stratified analyses found 17 % frailty and 58.4 % pre-frailty in the 70–74 age group, and 16.7 % and 54.2 % in those above 75 years. Cross-sectional studies showed 18.8 % frailty and 48.1 % pre-frailty, while cohort studies showed 18.1 % and 50.5 %, respectively. Asia had higher rates (22.7 % frailty, 43.5 % pre-frailty) than the Americas (9.9 % frailty, 56.3 % pre-frailty). By sample size, frailty prevalence was 21.3 % (&lt;500), 9.1 % (500–999), and 17.9 % (≥1000), with pre-frailty at 51.1 %, 45.6 %, and 47.7 %. The FP method yielded higher prevalence estimates (17.7 % frailty, 51.6 % pre-frailty) than the FS method (9.5 % frailty, 39.2 % pre-frailty).</div></div><div><h3>Conclusion</h3><div>This study provides insights into the prevalence of frailty and pre-frailty among community-dwelling elderly with multimorbidity. Variations in prevalence rates may be attributed to differences in sample size and measurement tools, which also contribute to heterogeneity observed across subgroups.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105782"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}