Archives of gerontology and geriatrics最新文献

{"title":"Differential effects of exercise training protocols on blood pressures and lipid profiles in older adults patients with hypertension: A systematic review and meta-analysis","authors":"Keyvan Hejazi ,&nbsp;Zahra Ataran Iraj ,&nbsp;Ayoub Saeidi ,&nbsp;Anthony C. Hackney ,&nbsp;Fatiha Laziri ,&nbsp;Katsuhuko Suzuki ,&nbsp;Ismail Laher ,&nbsp;Zouhal Hassane","doi":"10.1016/j.archger.2024.105737","DOIUrl":"10.1016/j.archger.2024.105737","url":null,"abstract":"<div><div>Decreased physical activity and high blood pressure are both risk factors for cardiovascular diseases. Controlling blood pressure within the normal range can prevent or delay these complications. This systematic review and meta-analysis analyzed the effects of different types of exercise training on the blood pressure and lipid profiles of older adults patients with hypertension. Five electronic databases (Web of Science, Cochrane, PubMed, Google Scholar, and Scopus) were searched from their inception until March 03, 2024. English publications and randomized controlled trials involving different types of exercise training treatments for hypertensive populations were included. Data were analyzed using a random-effects model to estimate weighted mean differences (WMD) and 95 % confidence intervals. The systematic search identified 1998 articles, of which 92 studies met the inclusion criteria and were deemed eligible for inclusion. The results of the meta‐analysis indicated that reduced systolic (SBP) and diastolic blood pressures (DBP) after aerobic training (<em>p &lt;</em> 0.01), resistance training (<em>p &lt;</em> 0.01), combined (aerobic + resistance) exercise training (<em>p &lt;</em> 0.01) and isometric handgrip training (<em>p &lt;</em> 0.01). Significant reductions were also observed in low-density lipoprotein (LDL) and triglyceride (TG) levels following combined (aerobic + resistance) exercise training (<em>p &lt;</em> 0.05 and <em>p &lt;</em> 0.001), and resistance training (<em>p &lt;</em> 0.01), respectively. High-density lipoprotein (HDL) levels were increased following aerobic training (<em>p &lt;</em> 0.01), and combined (aerobic + resistance) exercise training (<em>p &lt;</em> 0.01), but not after resistance and Tai chi training. Isometric handgrip training leads to greater reductions in blood pressure in hypertensive patients compared to the effects of aerobic, resistance, combined aerobic and resistance exercise, and tai chi training. Additional studies are needed to determine the exercise prescription protocols to maximize the health of older adults patients with hypertension.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105737"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional longitudinal associations between subjective oral health and subjective well-being","authors":"Taro Kusama ,&nbsp;Takamasa Komiyama ,&nbsp;Kenji Takeuchi ,&nbsp;Wael Sabbah ,&nbsp;Ken Osaka ,&nbsp;Jennifer E Gallagher","doi":"10.1016/j.archger.2024.105740","DOIUrl":"10.1016/j.archger.2024.105740","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the bidirectional longitudinal association between subjective oral health (SOH) and subjective well-being (SWB) over time.</div></div><div><h3>Methods</h3><div>This cohort study was based on a four-wave surveys conducted by the English Longitudinal Study of Aging. SOH was measured by oral impacts on daily performance (OIDP), self-rated oral health (SROH), and SWB was measured by the Center for Epidemiologic Studies-Depression (CES-D) scale, Control, Autonomy, Self-Realization, and Pleasure (CASP-19), and satisfaction with life scale (SWLS). To evaluate the bidirectional associations between SOH and SWB, separate models were created using SOH and SWB as the outcome and exposure, respectively. Additionally, the synchronous and lagged effects of exposure on outcomes were checked by employing exposures measured at different time points. A generalized estimating equation model was fitted, including the exposure variables, outcome variables in the previous wave, and baseline covariates.</div></div><div><h3>Results</h3><div>Among 4,510 participants (mean age=61.7 years [1SD=7.9], men=43.1 %), 8.1 %, 18.2 %, 14.3 %, 30.5 %, and 25.0 % had poor SOH and SWB as measured by OIDP, SROH, CES-D, CASP-19, and SWLS at baseline, respectively. The results of the regression models with all combinations of SOH and SWB measures showed that poor conditions of SOH or SWB were significantly associated with poor conditions of the other measures (all p &lt; 0.05). In almost all combinations of SOH and SWB measures, the synchronous effect was stronger than the lagged effect.</div></div><div><h3>Conclusion</h3><div>SOH and SWB are closely linked, and comprehensive care that considers oral health could contribute to well-being later in life.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105740"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesencephalic astrocyte-derived neurotrophic factor inhibits neuroinflammation through autophagy-mediated α-synuclein degradation","authors":"Kai-Ge Zhou ,&nbsp;Yi-Bin Huang ,&nbsp;Zi-Wen Zhu ,&nbsp;Ming Jiang ,&nbsp;Ling-Jing Jin ,&nbsp;Qiang Guan ,&nbsp;Lu-Lu Tian ,&nbsp;Jing-Xing Zhang","doi":"10.1016/j.archger.2024.105738","DOIUrl":"10.1016/j.archger.2024.105738","url":null,"abstract":"<div><div>Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder marked by the progressive loss of dopamine neurons in the substantia nigra. α-synuclein (SNCA) aggregation-induced microglia activation and neuroinflammation play vital role in the pathology of PD. Our previous studies showed that mesencephalic astrocyte-derived neurotrophic factor (MANF) could inhibit SNCA accumulation and Lipopolysaccharides (LPS)-induced neuroinflammation, but the specific molecular mechanism remains unclear. In this study, we showed that knock-down the expression of MANF leads to the up-regulation of inflammatory factor tumor necrosis factor-α (TNF-α). Exogenous MANF protein inhibits LPS-induced neuroinflammation in BV2 cells. Additionally, our results indicated that knock-down of the expression of MANF triggered autophagic pathway dysfunction, while exogenous addition of MANF protein or using adeno-associated virus 8 (AAV8) mediated MANF over-expression could activate the autophagic system and subsequently suppress SNCA accumulation. Furthermore, using autophagy inhibitor to block autophagic flux, we found that MANF prevented neuroinflammation by autophagy-mediated SNCA degradation. Collectively, this study indicated that MANF has potential therapeutic value for PD. Autophagy and its role in MANF-mediated anti-inflammatory properties may provide new sights that target SNCA pathology in PD.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105738"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary live microbe intake with all-cause and cardiovascular mortality in an older population: Evidence from NHANES 2003-2018","authors":"Shuang Zheng ,&nbsp;Yanqing Lou ,&nbsp;Jiali Zhang ,&nbsp;Yu Wang ,&nbsp;Lugang Lv","doi":"10.1016/j.archger.2024.105741","DOIUrl":"10.1016/j.archger.2024.105741","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between dietary live microbe intake, non-dietary prebiotics/probiotics, and mortality in older adults remains unclear.</div></div><div><h3>Methods</h3><div>Participants from the National Health and Nutrition Examination Survey 2003–2018 were included. Participants were categorized into three groups based on estimated live microbe intake: low, medium, and high. Additionally, they were divided by their consumption of foods with medium or high microbial content. Text mining was employed to identify the use of non-dietary prebiotics and probiotics by analyzing the names and ingredients of dietary supplements and drugs. Associations between live microbe intake, non-dietary prebiotics/probiotics, and all-cause or cardiovascular mortality were assessed using Kaplan-Meier survival curves and Cox regression models. Inverse Probability of Treatment Weighting was used for sensitivity analysis</div></div><div><h3>Result</h3><div>A total of 7882 participants were included in the study. During a mean follow-up of 8.08 years, all-cause mortality was 18 % lower in older adults with high dietary live microbe intake in fully adjusted models (HR, 0.82; 95 %CI 0.70–0.96), and cardiovascular mortality was reduced by 23 % (HR, 0.77; 95 %CI 0.61–0.98). The risk of all-cause mortality was reduced by 21 % in the G3 group compared with the G1 group (HR, 0.79; 95 % CI 0.69–0.89) and a 29 % reduction in the risk of cardiovascular disease-specific death (HR, 0.71;95 %CI 0.59–0.86). In addition, we also observed that nondietary prebiotic and probiotic supplement intake was also associated with a reduced risk of mortality in an older US population.</div></div><div><h3>Conclusion</h3><div>In older U.S. adults, higher dietary live microorganisms and non-dietary probiotics/prebiotics intake was associated with a reduced risk of all-cause and cardiovascular mortality.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105741"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional associations of grip strength-gait speed with mild cognitive impairment and specific cognitive abilities among older adults: A longitudinal analysis","authors":"Shijun Yang ,&nbsp;Jie Li ,&nbsp;Peipei Fu ,&nbsp;Yihong Sun ,&nbsp;Yang Liu ,&nbsp;Chengchao Zhou","doi":"10.1016/j.archger.2024.105733","DOIUrl":"10.1016/j.archger.2024.105733","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies showed that physical performance was associated with mild cognitive impairment (MCI). As the easily measured aging biomarkers, grip strength and gait speed could effectively reflect physical function. However, whether grip strength, gait speed, and the combination of the two were bidirectionally associated with MCI and specific cognitive function domains, have not been explored.</div></div><div><h3>Methods</h3><div>The bidirectional relationships between grip strength and MCI, gait speed and MCI, and the combination of grip strength with gait speed and MCI, were examined by generalized estimating equation (GEE). GEE was performed to further estimate the bidirectional relationships between grip strength combined with gait speed and the five domains of cognitive function, respectively.</div></div><div><h3>Results</h3><div>In total, 2,227 older adults (3 waves) were included. The MCI risk was higher for low grip strength group (OR = 1.78; <em>P</em> &lt; 0.001) compared to normal grip strength group, as well as higher for low gait speed group (OR = 1.71; <em>P</em> &lt; 0.001) compared to normal gait speed group. Low grip strength combined with low gait speed had the maximum associations with MCI (OR = 4.13; <em>P</em> &lt; 0.001) and decline in orientation, immediate memory, delayed memory, attention and calculation, and language. Older adults with MCI and decline in those five domains of cognition also longitudinally related to lower grip strength and lower gait speed.</div></div><div><h3>Conclusion</h3><div>The main findings revealed the importance of regularly monitoring grip strength, gait speed, global cognition, and specific cognitive function domains among older people. Early interventions for grip strength, gait speed, and cognition function might achieve reciprocal benefits.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105733"},"PeriodicalIF":3.5,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-based going-out program and dementia onset in Japanese older adults: A longitudinal observational study","authors":"Masanori Morikawa ,&nbsp;Kenji Harada ,&nbsp;Satoshi Kurita ,&nbsp;Chiharu Nishijima ,&nbsp;Kazuya Fujii ,&nbsp;Daisuke Kakita ,&nbsp;Yukari Yamashiro ,&nbsp;Naoto Takayanagi ,&nbsp;Motoki Sudo ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2024.105736","DOIUrl":"10.1016/j.archger.2024.105736","url":null,"abstract":"<div><h3>Objectives</h3><div>With dementia prevalence rising globally among older adults, effective and scalable community-based interventions are urgently needed to reduce dementia onset. This study aimed to estimate the association of the going-out program with dementia onset in older adults.</div></div><div><h3>Methods</h3><div>A 5-year longitudinal observational study was employed. Following a baseline assessment in 2015 and 2017, we observed 2,977 individuals engaging in a community-based going-out program for 12 months in Japan. Participants with continuous data over 12 months were defined as the engaged group, while those without such data were classified as the non-engaged group. After propensity score matching, 1,690 participants were selected. Dementia onset was obtained from the Japanese National Health Insurance and Later-Stage Medical Care System for 48-month follow-up. Incidence of dementia, absolute risk reduction (ARR), and number needed to treat (NNT) were calculated. The Cox proportional hazards model was used to estimate the effect of engagement in the program on dementia onset and to calculate a hazard ratio and 95 % confidential interval (CI).</div></div><div><h3>Results</h3><div>The incidence of dementia onset was 59 out of 845 (7.0 %) in the non-engagement group and 34 out of 845 (4.0 %) in the engagement group. The ARR rate was 3.0 % (95 % CI 0.8, 5.2), and the NNT was 33 (95 % CI 19, 125). The hazard ratio was 0.57 (95 % CI 0.37, 0.86).</div></div><div><h3>Discussion</h3><div>Engagement in the going-out program resulted in a 3.0 % reduction in the risk of dementia onset. The going-out program, which can be implemented in communities, holds potential efficacy in preventing dementia onset.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105736"},"PeriodicalIF":3.5,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of resistance training on inflammatory markers, body composition and functional capacity in healthy older adults: A systematic review and meta-analysis","authors":"Ali Nejatian Hoseinpour ,&nbsp;Minoo Bassami ,&nbsp;Sajad Ahmadizad ,&nbsp;Lars Donath ,&nbsp;Shayan Setayesh ,&nbsp;Meraj Mirzaei ,&nbsp;Gholam Rasul Mohammad Rahimi","doi":"10.1016/j.archger.2024.105731","DOIUrl":"10.1016/j.archger.2024.105731","url":null,"abstract":"<div><h3>Background</h3><div>: Older adults experience chronic inflammation, which is associated with health conditions such as sarcopenia, and resulting in reduced functional capacity. Resistance training (RT) is a beneficial intervention for improving health in the elderly.</div></div><div><h3>Objective</h3><div>: This study aimed to investigate the effect of RT on inflammatory biomarkers, body composition, and functional capacity in healthy adults aged 60 years and over. Additionally, this study conducted a meta-regression to investigate the moderating effect of exercise variables on inflammatory markers.</div></div><div><h3>Method</h3><div>: Medline, PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar were searched systematically until December 2023. Randomized controlled trials (RCTs) assessing the impact of RT on C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), body weight, BMI, fat percentage, fat mass, lean mass, leg extension strength and six-minute walk test (6-MWT) were included. Effect size was estimated by using the mean difference (MD) with 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>: Nineteen RTCs involving 728 participants were included. The results revealed that CRP levels significantly decreased following RT programs (MD:0.74, <em>p</em> <em>=</em> 0.008), while TNF-α (MD: 0.1, <em>p</em> <em>=</em> 0.95) and IL-6 (MD:0.27, <em>p</em> <em>=</em> 0.12) did not show significant changes. Additionally, RT enhanced leg extension strength and 6-MWT performance.</div></div><div><h3>Conclusion</h3><div>: RT effectively reduces CRP concentrations and enhances functional capacity in healthy older adults. However, it does not have a significant impact on TNF-α and IL-6 levels. Future researches are needed to make a clear conclusion and understand the mechanisms underlying the effects of RT in healthy older adults.</div><div><strong>Registration:</strong> The original protocol was registered (CRD42023487573) in PROSPERO database.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105731"},"PeriodicalIF":3.5,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea consumption and cognitive health in Chinese older adults: A propensity score matching and weighting analysis","authors":"Jie Huang ,&nbsp;Jiaqi Xu ,&nbsp;Yiqing Gu ,&nbsp;Hao Sun ,&nbsp;Huan Liu ,&nbsp;Yan He ,&nbsp;Mengjie Li ,&nbsp;Xin Gao ,&nbsp;Zaixiang Tang ,&nbsp;Hongfen Wang","doi":"10.1016/j.archger.2024.105735","DOIUrl":"10.1016/j.archger.2024.105735","url":null,"abstract":"<div><h3>Background</h3><div>The association between tea consumption, especially different types, and cognitive function has not been adequately explored. This study aimed to investigate the associations of tea consumption, including status, frequency, and type, with cognitive function, considering selection bias.</div></div><div><h3>Methods</h3><div>We used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2018(<em>N</em> = 8498). Cognitive function was measured by Mini-Mental State Examination (MMSE). Logistic and linear regression were applied to assess the associations of tea consumption with cognitive impairment and cognitive scores, respectively. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to balance characteristic differences between groups.</div></div><div><h3>Results</h3><div>The characteristics of tea consumption status, frequency and type were well balanced between groups after using PSM and IPTW. Drinking tea was associated with less cognitive impairment (OR_adjusted:0.84, OR_PSM:0.84, OR_IPTW:0.87) and higher cognitive scores (Coefficient_adjusted:0.29, Coefficient_PSM:0.33, Coefficient_IPTW:0.29). Regular tea drinkers may have better cognitive function than those who never or rarely consumed (<em>P</em>_trend &lt; 0.05 for both methods). Green tea drinkers had lower prevalence of cognitive impairment (OR_adjusted:0.71, OR_IPTW:0.75) and higher cognitive scores (Coefficient_adjusted:0.45, Coefficient_IPTW:0.54). Men, uneducated, and those with annual income&gt;10,000 RMB were more likely to benefit from flower tea. Significant interactions of tea consumption with age, education and income were observed.</div></div><div><h3>Conclusions</h3><div>Tea consumption, especially regular and green tea consumption, was associated with less cognitive impairment and higher cognitive scores, even after PSM and IPTW adjustments. Flower teas may have potential protective effect that is worth further study. Age, education and income have synergistic effects with tea consumption on cognitive function.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105735"},"PeriodicalIF":3.5,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of PGAM5 hyperactivation reduces neuronal apoptosis in PC12 cells and experimental vascular dementia rats","authors":"Ding Zhang ,&nbsp;Fangcun Li ,&nbsp;Chunying Sun ,&nbsp;Canrong Chen ,&nbsp;Hongling Qin ,&nbsp;Xuzhou Wu ,&nbsp;Minghe Jiang ,&nbsp;Keqing Zhou ,&nbsp;Chun Yao ,&nbsp;Yueqiang Hu","doi":"10.1016/j.archger.2024.105732","DOIUrl":"10.1016/j.archger.2024.105732","url":null,"abstract":"<div><h3>Purpose</h3><div>The incidence of vascular dementia (VaD), as one of the main types of dementia in old age, has been increasing year by year, and exploring its pathogenesis and seeking practical and effective treatment methods are undoubtedly the key to solving this problem. Phosphoglycerate translocase 5 (PGAM5), as a crossroads of multiple signaling pathways, can lead to mitochondrial fission, which in turn triggers the onset and development of necroptosis, and thus PGAM5 may be a novel target for the prevention and treatment of vascular dementia.</div></div><div><h3>Methods</h3><div>Animal model of vascular dementia was established by Two-vessel occlusion (2-VO) method, and cellular model of vascular dementia was established by oxygen glucose deprivation (OGD) method. Neuronal damage was detected in <em>vivo</em> and in <em>vitro</em> in different groups using different concentrations of the PGAM5-specific inhibitor LFHP-1c, and necroptosis and mitochondrial dynamics-related factors were determined.</div></div><div><h3>Results</h3><div>In <em>vivo</em> experiments, 10 mg/kg^-1 and 20 mg/kg^-1 LFHP-1c improved cognitive deficits, reduced neuronal edema and vacuoles, increased the number of nissl bodies, and it could modulate the expression of Caspase family and Bcl-2 family related proteins and mRNAs and ameliorate neuronal damage. Simultaneously, in <em>vitro</em> experiments, 5 μM, 10 μM and 20 μM LFHP-1c increased the activity and migration number of model cells, reduced the number of apoptotic cells, ameliorated the excessive accumulation of intracellular reactive oxygen species, inhibited the over-activation of caspase-family and Bcl-2-family related proteins and mRNAs, and improved the mitochondrial dynamics of the fission and fusion states. Moreover, in <em>vivo</em> and in <em>vitro</em> experiments have shown that LFHP-1c can also upregulate the expression level of BDNF, inhibit the expression content of TNF-α and ROS, regulate the expression of proteins and mRNAs related to the RIPK1/RIPK3/MLKL pathway and mitochondrial dynamics, and reduce neuronal apoptosis.</div></div><div><h3>Conclusions</h3><div>Inhibition of PGAM5 expression level can reduce neuronal damage caused by chronic cerebral ischemia and hypoxia, which mainly prevents necroptosis by targeting the RIPK1/RIPK3/MLKL signaling pathway and regulates the downstream mitochondrial dynamics homeostasis system to prevent excessive mitochondrial fission, thus improving cognition and exerting cerebroprotective effects.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105732"},"PeriodicalIF":3.5,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and prognostic value of dementia in atrial fibrillation patients in emergency departments: Insights from a national-wide multicenter registry study","authors":"Hanyang Liang,&nbsp;Jiangshan Tan,&nbsp;Wei Xu,&nbsp;Siqi Lyu,&nbsp;Shuang Wu,&nbsp;Juan Wang,&nbsp;Xinghui Shao,&nbsp;Han Zhang,&nbsp;Yanmin Yang","doi":"10.1016/j.archger.2024.105734","DOIUrl":"10.1016/j.archger.2024.105734","url":null,"abstract":"<div><h3>Introduction</h3><div>Atrial fibrillation (AF) and dementia are two common comorbidities in emergency departments (ED) that can significantly affect patients’ quality of life. The aim of this study was to evaluate the prevalence and long-term impact of dementia on survival in patients with AF.</div></div><div><h3>Methods</h3><div>We conducted a multicenter prospective observational study and consecutively recruited 2016 AF patients from 20 hospitals in China. The primary endpoint was all-cause mortality and the secondary endpoint was stroke. Multivariate logistic regression and odds ratio (OR) were used to identify clinical factors associated with AF patients with dementia. Four multivariate adjusted Cox proportional hazard models were conducted to evaluate the risk factors associated with endpoints.</div></div><div><h3>Results</h3><div>Totally, 2.2 % of AF patients were found to have dementia in ED. Older age (OR 1.05, 95 % CI 1.02–1.09, <em>P</em> = 0.005), coronary artery disease (OR 2.61, 95 % CI 1.21–6.05, <em>P</em> = 0.019), previous stroke or transient ischemic attack (TIA) (OR 5.67, 95 %CI 2.92–11.26, <em>P</em> &lt; 0.001) and prior major bleeding (OR 3.89, 95 %CI 1.11–11.49, <em>P</em> = 0.021) were independent risk factors for patients with both AF and dementia. During one-year follow-up, Log-rank analysis presented that dementia decreased overall survival (<em>P</em> &lt; 0.001) and had a higher incidence of stroke (<em>P</em> &lt; 0.001). After adjusting age, body mass index, blood pressure, type of AF, comorbidities and treatments, multivariate Cox models showed that dementia was independently associated with increased mortality and increasing risk of stroke.</div></div><div><h3>Conclusions</h3><div>Dementia significantly affects the survival and stroke incidence in AF patients. Prioritizing cognitive function screening and comprehensive care in ED is crucial for managing AF effectively.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105734"},"PeriodicalIF":3.5,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}