Archives of gerontology and geriatrics最新文献

{"title":"Multiple chronic conditions and polypharmacy in cognitively unimpaired older adults are associated with subsequent cognitive decline: results from the national alzheimer's coordinating center data","authors":"Chooza Moon ,&nbsp;Meina Zhang ,&nbsp;Boxiang Wang ,&nbsp;Sue E. Gardner ,&nbsp;Joel C. Geerling ,&nbsp;Karin F. Hoth","doi":"10.1016/j.archger.2025.105846","DOIUrl":"10.1016/j.archger.2025.105846","url":null,"abstract":"<div><div>Prior cross-sectional studies revealed that multiple chronic conditions (MCC) and polypharmacy are associated with cognitive impairment. The purpose of this study was to determine whether the number of chronic conditions and the number of medications are associated with longitudinal changes in cognition (memory, attention/working memory, semantic ability/language, processing speed, executive function). We analyzed data from 5671 individuals (age 71.4 ± 9.3, 68 % female) from the National Alzheimer's Coordinating Center database who were cognitively unimpaired at baseline and had 3 or more subsequent visits. 57 % had more than two chronic conditions, and 44 % were taking 5 or more medications at baseline. At baseline, we observed that individuals with MCC had lower memory, attention/working memory, semantic ability/language, processing speed, and executive function performance than those without MCC. Using mixed-effect modeling approaches, we found that having a higher number of chronic conditions was associated with greater decline in semantic ability/language and executive function, and having a higher number of medications was associated with greater decline in attention/working memory, semantic ability/language, and executive function. The findings suggest that healthcare professionals and service providers should be conscious of the fact that patients dealing with MCC and those on multiple medications are vulnerable and require careful monitoring. Future studies are warranted using more comprehensive multimorbidity data and advanced analytic approaches, and prospective, controlled trials are warranted to test whether managing MCC and reducing the number of unnecessary medications or certain medications can prevent decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105846"},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and burden of age-related hearing loss: 32-year study","authors":"Lingkang Dong ,&nbsp;Wenqi Dong ,&nbsp;Shihui Zhang ,&nbsp;Yuchen Jin ,&nbsp;Yumeng Jiang ,&nbsp;Zhuangzhuang Li ,&nbsp;Chunyan Li ,&nbsp;Dongzhen Yu","doi":"10.1016/j.archger.2025.105847","DOIUrl":"10.1016/j.archger.2025.105847","url":null,"abstract":"<div><h3>Background</h3><div>Age-related hearing loss (ARHL) is a major cause of disability and diminished quality of life in older adults. This study uses data from the 2021 Global Burden of Disease (GBD) study to assess global ARHL.</div></div><div><h3>Methods</h3><div>We evaluated ARHL prevalence, DALYs (Disability-Adjusted Life Years), ASPR (Age-Standardized Prevalence Rate), and ASDR (Age-Standardized DALYs Rate). Trend analysis was conducted using Estimated Annual Percentage Change (EAPC), with projections to 2050.</div></div><div><h3>Result</h3><div>From 1990 and 2021, global ARHL prevalence cases and DALYs increased by 109 %, reaching 1.55 billion and 44.45 million, respectively. The ASPR increased from 17,106.88 to 18,070.26, while the crude prevalence rate significantly from 13,890.66 to 19,587.14. Both ASPR and ASDR demonstrated significant age-related increases, particularly for moderate and moderately severe ARHL, with EAPC values of 1.39 and 1.49 for ASDR, respectively. Among individuals aged over 85 years, the ASPR of ARHL is expected to reach 80 %. Prevalence cases peaked in the 55–69 age group, with the highest number of cases (179.43 million) observed in the 55–59 subgroup. High-middle SDI regions and East Asia exhibited the most rapid growth. By 2050, ARHL cases are projected to reach 2.31 billion, with ASPR and ASDR expected to continue rising.</div></div><div><h3>Conclusion</h3><div>ARHL has increased globally over the past three decades, largely due to population aging. The burden is most severe in middle SDI regions, East Asia, and the 55–69 age group, primarily due to their substantial population bases. Addressing this escalating challenge requires enhanced public awareness, early screening initiatives, and targeted interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105847"},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative blood pressure burden and the risk of functional dependence in elderly cohorts: An exploration of the influencing factors","authors":"Yanfen Hu ,&nbsp;Junxia Yu ,&nbsp;Zhenjie Xu ,&nbsp;Lingxia Li","doi":"10.1016/j.archger.2025.105849","DOIUrl":"10.1016/j.archger.2025.105849","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the correlation between cumulative blood pressure levels and functional dependence in individuals aged 60 and older.</div></div><div><h3>Methods</h3><div>Data were sourced from two distinct elderly databases: CHARLS and ELSA. Various statistical techniques, including logistic regression analysis, restricted cubic spline analysis, forest plot visualization, and interaction analyses, were employed to delve into the associations between cumulative blood pressure and difficulties in performing activities of daily living.</div></div><div><h3>Results</h3><div>Across both cohorts, there was a discernible trend towards an increased risk of ADL difficulties with escalating cumulative blood pressure levels. Logistic regression analysis confirmed a statistically significant relationship between cumulative blood pressure and ADL difficulties (<em>P</em> &lt; 0.001). The results derived from restricted cubic spline plots further underscored this relationship, demonstrating that, after adjusting for a multitude of confounding factors, the risk of ADL difficulties augmented with rising cumulative blood pressure. Additionally, the forest plot and interaction plot findings revealed that the association between heightened cumulative blood pressure and the risk of ADL difficulties was contingent upon factors such as body mass index, gender, and memory-related disorders.</div></div><div><h3>Conclusions</h3><div>Our findings indicate a positive correlation between cumulative blood pressure and the risk of experiencing difficulties with ADLs. Furthermore, this association appears to be modulated by BMI, gender, and the presence of memory-related diseases.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105849"},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of metabolic dysfunction-related fatty liver disease and dementia risk: A prospective study based on the UK biobank","authors":"Chaofan Geng ,&nbsp;Peiyang Gao ,&nbsp;Yi Tang","doi":"10.1016/j.archger.2025.105845","DOIUrl":"10.1016/j.archger.2025.105845","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention for its potential link with dementia. This study aims to investigate the association between MAFLD and dementia, including its subtypes, to address existing knowledge gaps.</div></div><div><h3>Methods</h3><div>A total of 415,116 participants from the UK Biobank were included, with standardized screening criteria used to determine MAFLD diagnosis. Cox regression was employed to assess the relationship between MAFLD and dementia risk. Subgroup analyzes were conducted to provide further insights into the impact of MAFLD on dementia risk, and the mediation effect of inflammation was evaluated.</div></div><div><h3>Results</h3><div>Among the 150,509 MAFLD patients, there was a significantly elevated risk of dementia, with hazard ratios (HR) of 1. 526 (95 % CI = 1. 460–1. 596) for all-cause dementia, 1. 356 (95 % CI = 1. 266–1. 453) for Alzheimer's disease (AD), and 2. 206 (95 % CI = 2. 000–2. 434) for vascular dementia (VaD). MAFLD patients showed a significant reduction in gray matter volume in MAFLD patients (β = -0. 07, 95 % CI = -0. 17, -0. 01) and a marked increase in deep white matter lesion volume (<em>P</em> &lt; 0. 001). Elevated inflammatory markers in MAFLD patients accounted for a mediation effect of 30. 8 %<strong>.</strong></div></div><div><h3>Conclusion</h3><div>MAFLD substantially increases the risk of dementia, underscoring the importance of early intervention and prevention strategies targeting MAFLD to reduce dementia incidence.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105845"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, awareness, behaviours, beliefs, attitudes, and perceptions of older Australians regarding muscle health and sarcopenia: A national survey","authors":"Robin M. Daly,&nbsp;David Scott,&nbsp;Nicole Kiss,&nbsp;Michael Tieland,&nbsp;Brenton Baguley,&nbsp;Jackson J. Fyfe","doi":"10.1016/j.archger.2025.105835","DOIUrl":"10.1016/j.archger.2025.105835","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated older Australians understanding, awareness, knowledge, perceptions, behaviours, beliefs and attitudes towards muscle health and sarcopenia, and barriers towards exercise and nutrition as prevention options.</div></div><div><h3>Methods</h3><div>A national, anonymous 41-question, online purpose-designed survey covering the concepts outlined in the study objective was conducted from March-May 2024.</div></div><div><h3>Results</h3><div>1261 adults (≥50-y) aged 50–94 years participated. Low muscle strength and poor function were the most common criteria associated with poor muscle health. Knowledge of common signs/symptoms, risk factors, consequences, and effective treatments was generally high. However, there was uncertainty about unintentional weight loss as a risk factor, increased risk for infection/reduced immunity and chronic conditions as consequences, and ineffective treatments options (only 5–12 % recognised any form of exercise, aerobic exercise and eating more fruits/vegetables as ineffective treatments). Only 8.9 % reported their doctor had discussed muscle health but 82–95 % would act if they received information on risk factors or if informed they were at risk for poor muscle health. Two-thirds recognised sarcopenia as a serious condition, with 48 % concerned about its potential impact, despite 90 % acknowledging muscle health is very important to maintain. Only around half believed they had sufficient knowledge and confidence to adopt lifestyle changes to reduce their risk, with motivation the leading barrier to engaging in exercise or dietary strategies to optimize muscle health.</div></div><div><h3>Conclusion</h3><div>Older Australians recognize the importance of muscle health, understand key strategies to manage it and would act if identified to be at risk, but many lack knowledge and confidence to adopt lifestyle changes to improve their muscle health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105835"},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence applications and aging (1995–2024): Trends, challenges, and future directions in frailty research","authors":"Ali Mufraih Albarrati ,&nbsp;Rakan Nazer ,&nbsp;Siddig Ibrahim Abdelwahab ,&nbsp;Mohammed Albratty","doi":"10.1016/j.archger.2025.105837","DOIUrl":"10.1016/j.archger.2025.105837","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, a significant predictor of adverse health outcomes, has become a focal point of research, particularly with the advent of artificial intelligence (AI) technologies. This study aimed to provide a comprehensive bibliometric analysis of research trends in AI and frailty to map conceptual developments, collaborations, and emerging themes in the field.</div></div><div><h3>Methods</h3><div>A systematic search was conducted using the Scopus database employing a comprehensive set of keywords related to AI and frailty. The search was refined to include only original articles in English, yielding 1213 documents. Data extraction was performed in October 2024 and exported in the CSV and BibTeX formats. Annual growth trends were analyzed using Microsoft Excel, while VOSviewer and R-package were used for bibliometric analyzes and visualization to identify key contributors, collaborations, and thematic clusters.</div></div><div><h3>Results</h3><div>The analysis revealed rapid growth in research publications, with AI applications in frailty gaining prominence over the past decade. Thematic clusters highlight areas such as predictive modeling, machine learning applications, and geriatric care innovations. The United States, United Kingdom, and Italy emerged as leading contributors to publications and collaborations. The key topics included prediction models, dementia, sarcopenia, and rehabilitation. This bibliometric study underscores the increasing integration of AI into frailty research, revealing key trends, collaborative networks, and emerging areas of focus.</div></div><div><h3>Conclusion</h3><div>These findings can guide future research, foster collaborations, and enhance the application of AI technologies to improve frailty assessment and management.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105837"},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance care planning procedure in older patients at a high risk of death after discharge from the acute geriatric unit: A study protocol","authors":"Fabien Visade ,&nbsp;Guillaume Deschasse ,&nbsp;Frédéric Roca ,&nbsp;Cédric Villain ,&nbsp;Sylvia Pelayo ,&nbsp;Romaric Marcilly ,&nbsp;Matthieu Calafiore ,&nbsp;Paul Quindroit ,&nbsp;Chloé Prod'homme ,&nbsp;Clémence Levesque ,&nbsp;Williams Vandenberghe ,&nbsp;Laurène Norberciak ,&nbsp;Marie Buttitta ,&nbsp;Carla Di Martino ,&nbsp;Jean-Baptiste Beuscart","doi":"10.1016/j.archger.2025.105836","DOIUrl":"10.1016/j.archger.2025.105836","url":null,"abstract":"<div><div>The SAPHARI (“Home-based Nurse Intervention in the Care of High-Risk-of-Death Patients after Discharge from a Geriatric Department”) prospective, multicenter, randomized, controlled, open-label study has been designed to evaluate the effectiveness of implementing advance care planning (ACP) in older patients at a high risk of death. Patients aged 75 or over, at a high risk of death (according to the DAMAGE prognostic score) and discharged alive to home or to a nursing home from an acute geriatric unit will be included and followed up for 12 months. We plan to randomize 104 patients into a control group or an intervention group. The patients in the intervention group will receive an in-home intervention by an expert advanced practice nurse trained in the implementation of ACP. The primary outcome will focus on the intervention's feasibility: the proportion of patients included and randomized, the proportion completing in the study, and the proportion having engaged in ACP within a month of discharge. A secondary efficacy outcome will be compliance with advance directives (drafted at the time of ACP) at 12 months in each of the two study groups. Symptom's of anxiety and depression, the intervention's acceptability, and changes in quality of life will be documented in patients, family carers, and professional caregivers. The patients' and caregivers' experience of the intervention will be explored in qualitative analyses. Lastly, the intervention's implementation will be analyzed, with a view to understanding the results and identifying factors that will foster generalization of the conclusions. Through this project, we hope to lay the foundations for better care of very frail older patients at the end of life. The results of our study will provide robust, scientific evidence to fuel the long-standing but evolving social and political debate over the right to a dignified end of life.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105836"},"PeriodicalIF":3.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerable blood pressure control levels do not impact mortality of patients over 80-year-old: Insights from NHANES 2009-2018","authors":"Yueqiao Si ,&nbsp;Binjun Lu ,&nbsp;Lanlan Ma ,&nbsp;Juanjuan Zheng ,&nbsp;Wei Eric Wang","doi":"10.1016/j.archger.2025.105828","DOIUrl":"10.1016/j.archger.2025.105828","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the impact of blood pressure levels on all-cause and cardiovascular disease (CVD) mortality in hypertensive patients over 80-year-old using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2018.</div></div><div><h3>Methods</h3><div>A total of 8406 hypertensive patients under 80-year-old and 1082 hypertensive patients over 80-year-old were included. Kaplan-Meier curves, Cox proportional hazards regression models, and restricted cubic spline plots were employed.</div></div><div><h3>Results</h3><div>In patients over 80-year-old, neither systolic blood pressure (SBP) nor diastolic blood pressure (DBP) was significantly associated with all-cause or CVD mortality (<em>P</em> &gt; 0.05). However, in hypertensive patients under 80-year-old, significant differences in mortality were observed across different SBP and DBP subgroups (<em>P</em> &lt; 0.05), with an optimal SBP range of 120–140 mmHg associated with reduced all-cause mortality risk. In patients over 80-year-old, male patients, high urinary albumin-to-creatinine ratio, total cholesterol, red blood cells, and elevated lymphocyte and neutrophil percentages were associated with increased all-cause mortality; SBP interaction with these risk factors slightly reduced the hazard ratio values separately.</div></div><div><h3>Conclusion</h3><div>Based on NHANES data from 2009 to 2018, tolerable SBP and DBP levels appear to have no significant impact on all-cause or CVD mortality in hypertensive patients over 80-year-old”.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105828"},"PeriodicalIF":3.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors and comprehensive approaches for heart failure management in frail older adults","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105834","DOIUrl":"10.1016/j.archger.2025.105834","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105834"},"PeriodicalIF":3.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project","authors":"Ted K.S. Ng ,&nbsp;Todd Beck ,&nbsp;Xiaoran Liu ,&nbsp;Pankaja Desai ,&nbsp;Thomas Holland ,&nbsp;Klodian Dhana ,&nbsp;Kristin Krueger ,&nbsp;Robert S. Wilson ,&nbsp;Denis A. Evans ,&nbsp;Kumar B. Rajan","doi":"10.1016/j.archger.2025.105825","DOIUrl":"10.1016/j.archger.2025.105825","url":null,"abstract":"<div><h3>Background</h3><div>There have been contradictory findings on the associations between lipids and cognitive decline (CD), which may be attributed to the heterogeneity in the APOE4 carrier status, given APOE's lipid transportation roles. However, extant studies rarely examined the modifying effects of APOE4 carrier status on the associations between lipids and CD.</div></div><div><h3>Methods</h3><div>We analyzed the Chicago Health and Aging Project, a 20-year cohort study comprising older adults with lipid panel assayed, i.e., total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), and longitudinal cognitive tests. We ran adjusted linear mixed-effects models, regressing cognitive test composite on each of the four lipids independently, first with the total sample and subsequently using interaction and stratified subgroup analyses, examining the modifying effects of APOE4 carrier status on the associations.</div></div><div><h3>Results</h3><div>3,496 biracial community-dwelling older adults were recruited from the South side of Chicago (58% African American &amp; 64% women; mean follow-up = 4.6 years). In the total sample, there was a borderline association between TG and CD, estimate (SD, p-value) = 0.0001 (0.0000,0.0565). No associations were detected with other lipids. In the interaction and subgroup analyses, only in ε4 carriers that higher TC levels were significantly associated with accelerated CD, -0.020 (0.009,0.035), whereas higher TG levels were significantly associated with decelerated CD, 0.001 (0.001,0.045). No modifying effects of ε4 carrier status were detected with other lipids.</div></div><div><h3>Discussion</h3><div>Specific lipids, i.e., TC and TG, were associated with CD only in the ε4 carriers, highlighting the potential importance of measuring APOE4 status to better inform risk prediction and treatment.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105825"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}