Archives of gerontology and geriatrics最新文献

{"title":"Sensory impairments and the risk of cognitive decline and dementia across sex, age, and regions: Longitudinal insights from Europe","authors":"Sören Möller ,&nbsp;Jesper Lykkegaard ,&nbsp;Rikke Syrak Hansen ,&nbsp;Lonny Stokholm ,&nbsp;Niels Kristian Kjær ,&nbsp;Linda Juel Ahrenfeldt","doi":"10.1016/j.archger.2024.105584","DOIUrl":"10.1016/j.archger.2024.105584","url":null,"abstract":"<div><h3>Background</h3><p>In aging populations, understanding predictors of cognitive decline is essential. We aimed to investigate the risk of cognitive decline and dementia by sensory impairments across sex, age, and European regions, and examined the mediating role of activities of daily living (ADL), physical activity, and depressive symptoms.</p></div><div><h3>Methods</h3><p>A cohort study of 72,287 Europeans aged 50+ participating in at least two waves of the Survey of Health, Ageing and Retirement in Europe. We employed mixed-effects and time-to-event models, incorporating sex interactions, and adjusting for socio-demographic factors and medical history.</p></div><div><h3>Results</h3><p>Compared to individuals with good vision and hearing, lower cognitive function was found for people with vision impairment (VI) (males: coef. -0.70, 95 % CI -0.95; -0.46; females: coef. -1.12, 95 % CI -1.33; -0.92), hearing impairment (HI) (males: coef. -0.64, 95 % CI -0.93; -0.35; females: coef. -0.96, 95 % CI -1.27; -0.65) and dual sensory impairment (DSI, i.e. VI and HI) (males: coef. -1.81, 95 % CI -2.16; -1.46; females: coef. -2.71, 95 % CI -3.05; -2.38), particularly among females. Moreover, higher dementia risk was observed among participants with VI (hazard ratio (HR) 1.29, 95 % CI 1.17; 1.43), HI (HR 1.18, 95 % CI 1.05; 1.34), and DSI (HR 1.62, 95 % CI 1.45; 1.81) with no sex-interactions. Findings were overall consistent across age and European regions.</p></div><div><h3>Conclusion</h3><p>The results suggest the necessity of preventing sensory impairments to maintain good cognitive function. Mitigating depressive symptoms, ADL limitations, and physical inactivity could potentially reduce a significant portion of the total effect of sensory impairments on cognitive decline.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105584"},"PeriodicalIF":3.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cognitive function and sleep quality in middle-aged and older adults for minimizing disparities and achieving equity in health: Evidence from multiple nationwide cohorts","authors":"Junyu Wang ,&nbsp;Wei Wang ,&nbsp;Yaqiong Liu ,&nbsp;Menghan Yao ,&nbsp;Qianqian Du ,&nbsp;Yuxin Wei ,&nbsp;Kai Lu ,&nbsp;Chen Li ,&nbsp;Xuelin Li ,&nbsp;Sheng Li ,&nbsp;Xinyue Tian ,&nbsp;Tao Zhang ,&nbsp;Fei Yin ,&nbsp;Yue Ma","doi":"10.1016/j.archger.2024.105585","DOIUrl":"10.1016/j.archger.2024.105585","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive decline, a heavy burden on middle-aged and older adults as global aging is aggravated, was found to be associated with sleep quality. However, the country-between heterogeneity of the association prevented us from quantifying underlying relationship and identifying potential effect modifiers for vulnerable populations and targeted interventions.</p></div><div><h3>Methods</h3><p>We collected data from 79,922 eligible adults in five nationwide cohorts, examined the respective relationships between cognitive function and sleep quality, synthesized underlying average relationships by meta-analysis, and explored effect modifiers by meta-regressions. Additionally, we conducted subgroup and interaction analyses to identify vulnerable populations and to determine their disparities in vulnerability.</p></div><div><h3>Results</h3><p>Although country-between disparities exist, cognitive function is robustly associated with sleep quality in middle-aged and older adults worldwide, with an effect (<span><math><mi>β</mi></math></span>) of 0.015 [0.003, 0.027]. Executive function is the subdomain most relevant to sleep quality. Disparities in the effects of sleep quality on subdomains exist in populations with different sexes (orientation: <span><math><msub><mi>β</mi><mtext>female</mtext></msub></math></span>/<span><math><msub><mi>β</mi><mtext>male</mtext></msub></math></span> = 1.615, <em>P</em> = 0.020), marital statuses (orientation: <span><math><msub><mi>β</mi><mtext>unmarried</mtext></msub></math></span>/<span><math><msub><mi>β</mi><mtext>married</mtext></msub></math></span> = 2.074, <em>P</em> &lt; 0.001), education levels (orientation:<span><math><msub><mi>β</mi><mtext>uneducated</mtext></msub></math></span>/<span><math><msub><mi>β</mi><mtext>educated</mtext></msub></math></span> = 2.074, <em>P</em> &lt; 0.001) and chronic disease statuses (memory: <span><math><msub><mi>β</mi><mtext>unhealthy</mtext></msub></math></span>/<span><math><msub><mi>β</mi><mtext>healthy</mtext></msub></math></span> = 1.560, <em>P</em> = 0.005).</p></div><div><h3>Conclusions</h3><p>Cognitive function decreases with worsening sleep quality in middle-aged and older adults. Vulnerability to poor sleep generally persists in singles, females, the uneducated and people with chronic diseases. To minimize disparities and achieve health equity, we advocate for targeted interventions, i.e., encouraging socialization in singles, confirming effectiveness of hormone replacement therapy in females, employing compulsory education in middle-aged and older adults.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105585"},"PeriodicalIF":3.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin improves skeletal muscle and physical capacity by stabilizing neuromuscular junction in older adults","authors":"Rizwan Qaisar ,&nbsp;Mashal Javed ,&nbsp;Imran Muhammad Khan ,&nbsp;Firdos Ahmad ,&nbsp;Asima Karim","doi":"10.1016/j.archger.2024.105587","DOIUrl":"10.1016/j.archger.2024.105587","url":null,"abstract":"<div><h3>Objectives</h3><p>Metformin is an anti-diabetic drug with protective effects on skeletal muscle and physical capacity. However, the relevant mechanisms of action on skeletal muscle remain poorly understood. We investigated the potential contribution of neuromuscular junction (NMJ) degradation to skeletal muscle and physical capacity in geriatric men taking metformin.</p></div><div><h3>Method</h3><p>We recruited geriatric men for placebo (Age=73.1 ± 4.2 years, <em>n</em> = 70) and metformin (Age=70.1 ± 4.5 years, <em>n</em> = 62) groups. The patients in the metformin group received 1700 mg of metformin twice a day for 16 weeks. We measured plasma c-terminal agrin-fragment-22 (CAF22) and neurofilament light chain (NfL) as markers of neuromuscular junction (NMJ) degradation and neurodegeneration, respectively, with relevance to handgrip strength (HGS) and short physical performance battery (SPPB; a marker of physical capacity) in older adults taking metformin. These findings were associated with reduced oxidative stress in the metformin group.</p></div><div><h3>Results</h3><p>At baseline, both groups had similar HGS, gait speed, SPPB scores, and plasma biochemistry. Metformin improved HGS, gait speed, and cumulative SPPB scores in geriatric men (all <em>p</em> &lt; 0.05). Metformin also reduced plasma CAF22 and NfL levels when compared to baseline. Similar observations were not found in the placebo group. Correlation analysis revealed significant correlations of plasma CAF22 with HGS, gait speed, and cumulative SPPB scores in the metformin group. These observations were associated with reduced oxidative stress in the metformin group.</p></div><div><h3>Conclusion</h3><p>Altogether, the restorative effects of metformin on skeletal muscle and physical capacity involve NMJ stabilization. Our data is clinically relevant for geriatric men with functional disabilities.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105587"},"PeriodicalIF":3.5,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociation of focal and large-scale inhibitory functions in the older adults: A multimodal MRI study","authors":"Yi-Hsuan Liu ,&nbsp;Yi-Cheng Lin ,&nbsp;Ling-Chieh Shih ,&nbsp;Ching-Po Lin ,&nbsp;Li-Hung Chang","doi":"10.1016/j.archger.2024.105583","DOIUrl":"10.1016/j.archger.2024.105583","url":null,"abstract":"<div><h3>Background</h3><p>The decline of inhibitory in cognitive aging is linked to reduced cognitive and mental capacities in older adults. However, this decline often shows inconsistent clinical presentations, suggesting varied impacts on different inhibition-related tasks. Inhibitory control, a multifaceted construct, involves various types of inhibition. Understanding these components is crucial for comprehending how aging affects inhibitory functions. Our research investigates the influences of aging on large-scale and focal-scale inhibitory and examines the relationship with brain markers.</p></div><div><h3>Methods</h3><p>We examined the impact of aging on inhibitory in 18 younger (20–35 years) and 17 older adults (65–85 years) using focal and large-scale inhibition tasks. The Gabor task assessed focal-scale inhibition, while the Stop Signal Task (SST) evaluated large-scale inhibition. Participants underwent neuropsychological assessments and MRI scans, including magnetic resonance spectroscopy (MRS) and structural and resting fMRI.</p></div><div><h3>Results</h3><p>Older adults exhibited a marked decline in inhibitory function, with slower SST responses indicating compromised large-scale inhibition. Conversely, the Gabor task showed no significant age-related changes. MRS findings revealed decreased levels of GABA, glutamate, glutamine, and NAA in the pre-SMA, correlating with observed large-scale inhibition in older adults. Additionally, pre-SMA seed-based functional connectivity analysis showed reduced brain network connections in older adults, potentially contributing to inhibitory control deficits.</p></div><div><h3>Conclusions</h3><p>Our study elucidates the differential effects of aging on inhibitory functions. While large-scale inhibition is more vulnerable to aging, focal-scale inhibition is relatively preserved. These findings highlight the importance of targeted cognitive interventions and underscore the necessity of a multifaceted approach in aging research.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105583"},"PeriodicalIF":3.5,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0167494324002590/pdfft?md5=972004c8d3c30ed54fd69a21642e4cb5&pid=1-s2.0-S0167494324002590-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of cerebral atrophic rate in mild cognitive impairment and its interactive association with proteins related to microglia activity on longitudinal cognitive changes","authors":"Jingyi Tang ,&nbsp;Zhiyu Cao ,&nbsp;Ming Lei ,&nbsp;Qun Yu ,&nbsp;Yingren Mai ,&nbsp;Jiaxin Xu ,&nbsp;Wang Liao ,&nbsp;Yuting Ruan ,&nbsp;Lin Shi ,&nbsp;Lianhong Yang ,&nbsp;Jun Liu ,&nbsp;Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.archger.2024.105582","DOIUrl":"10.1016/j.archger.2024.105582","url":null,"abstract":"<div><h3>Background</h3><p>Heterogeneity of cerebral atrophic rate commonly exists in mild cognitive impairment (MCI), which may be associated with microglia-involved neuropathology and have an influence on cognitive outcomes.</p></div><div><h3>Objective</h3><p>We aim to explore the heterogeneity of cerebral atrophic rate among MCI and its association with plasma proteins related to microglia activity, with further investigation of their interaction effects on long-term cognition.</p></div><div><h3>Subjects</h3><p>A total of 630 MCI subjects in the ADNI database were included, of which 260 subjects were available with baseline data on plasma proteins.</p></div><div><h3>Methods</h3><p>Group-based multi-trajectory modeling (GBMT) was used to identify the latent classes with heterogeneous cerebral atrophic rates. Associations between latent classes and plasma proteins related to microglia activity were investigated with generalized linear models. Linear mixed effect models (LME) were implemented to explore the interaction effects between proteins related to microglia activity and identified latent classes on longitudinal cognitive changes.</p></div><div><h3>Results</h3><p>Two latent classes were identified and labeled as the slow-atrophy class and the fast-atrophy class. Associations were found between such heterogeneity of atrophic rates and plasma proteins related to microglia activity, especially AXL receptor tyrosine kinase (AXL), CD40 antigen (CD40), and tumor necrosis factor receptor-like 2 (TNF-R2). Interaction effects on longitudinal cognitive changes showed that higher CD40 was associated with faster cognitive decline in the slow-atrophy class and higher AXL or TNF-R2 was associated with slower cognitive decline in the fast-atrophy class.</p></div><div><h3>Conclusions</h3><p>Heterogeneity of atrophic rates at the MCI stage is associated with several plasma proteins related to microglia activity, which show either protective or adverse effects on long-term cognition depending on the variability of atrophic rates.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105582"},"PeriodicalIF":3.5,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sarcopenia and urinary dysfunction in patients with dysphagia","authors":"Shingo Kakehi ,&nbsp;Hidetaka Wakabayashi ,&nbsp;Eri Isono ,&nbsp;Ryohei Takemura ,&nbsp;Yuka Sato ,&nbsp;Yukiko Otsuka ,&nbsp;Takako Nagai ,&nbsp;Shinta Nishioka ,&nbsp;Ryo Momosaki","doi":"10.1016/j.archger.2024.105577","DOIUrl":"10.1016/j.archger.2024.105577","url":null,"abstract":"<div><h3>Introduction</h3><p>The objective was to determine the relationship between sarcopenia and urinary dysfunction in patients with dysphagia.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study was conducted on 460 Japanese Sarcopenic Dysphagia Database participants. Urinary dysfunction was defined as either urinary incontinence or urethral catheter use. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia 2019 criteria. Univariate and multivariate analyses assessed the association between urinary dysfunction and sarcopenia, calf circumference (CC), handgrip strength (HGS), and Barthel Index (BI). Logistic regression analysis was performed for urinary dysfunction adjusted for age, sex, setting, and CCI in addition to BI and HGS or CC or sarcopenia (model 1) or FILS and BI (model 2).</p></div><div><h3>Results</h3><p>The mean age was 80.8 ± 10.5 years and urinary dysfunction in 137 participants. Urinary dysfunction was not associated with sarcopenia (123 versus 281, <em>p</em> = 0.440) but was associated with CC (27.4 ± 4.2 versus 28.5 ± 3.9, <em>p</em> = 0.009), HGS (9.7 ± 7.9 versus 14.4 ± 9.3, <em>p</em> &lt; 0.001), and BI (19.9 ± 0.3 versus 20.3 ± 0.2, <em>p</em> &lt; 0.001). Logistic regression analysis showed urinary dysfunction was associated with HGS (OR: 0.968, CI: 0.938, 0.998) and BI (OR: 0.955, CI: 0.943, 0.966). The cutoff was 19 kg for men (sensitivity 0.786, specificity 0.56, Area Under Curve (AUC) 0.689) and 6.1 kg for women (sensitivity 0.493, specificity 0.774, AUC 0.639) in HGS and 27.5 points in BI (sensitivity 0.781, specificity 0.604, AUC 0.740).</p></div><div><h3>Conclusion</h3><p>Sarcopenia was not associated with urinary dysfunction. However, HGS and BI were related to urinary dysfunction.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105577"},"PeriodicalIF":3.5,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141729323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional causal associations between aging and major mental disorders: A population-based study using the two-sample mendelian randomization method from the UK biobank (AM-SRNMA 002)","authors":"Wenbo Huang ,&nbsp;Cheng Lin ,&nbsp;Mingxin Liu","doi":"10.1016/j.archger.2024.105578","DOIUrl":"10.1016/j.archger.2024.105578","url":null,"abstract":"<div><h3>Aims</h3><p>While observational studies have suggested associations linking aging and mental disorders, the question of causality has remained unclear. This study aimed to explore the causal relationship between aging level and major mental disorders.</p></div><div><h3>Methods</h3><p>We utilized Two-Sample Mendelian randomization (2SMR) with mental disorders data and aging indicators information from an extensive genome-wide association study (GWAS) database. The GWAS database is a comprehensive resource that compiles genetic association data, encompassing a sample size of over 450,000 individuals. We employed five methods for 2SMR and single nucleotide polymorphisms were chosen as instrumental variables.</p></div><div><h3>Results</h3><p>Our analyses consistently supported a bidirectional causal association between the Frailty Index (FI) and Major Depressive Disorder (MDD). Furthermore, our findings indicated potential influences, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Bipolar Disorder (BD) affecting GrimAge, and Anxiety Disorder (AD) impacting Left Hand Grip Strength (LHGS). In contrast, we observed no significant correlations for other mental disorders on FI, Telomere Length (TL), GrimAge, Appendicular Lean Mass (ALM), and LHGS. In the reverse direction, FI showed a significant impact on the risk of MDD, AD, and ADHD, while LHGS affected the risk of MDD. Importantly, no significant associations were found between other factors and the risk of MDD, BD, AD, Schizophrenia (SZ), and ADHD.</p></div><div><h3>Conclusions</h3><p>This 2SMR analysis has presented evidence for a bidirectional causal relationship between FI and MDD, while the relationship between ADHD, BD, and GrimAge should be more considered. Our study provides genetic evidence supporting a causal link between aging indicators and several mental illnesses.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105578"},"PeriodicalIF":3.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized interactive multimedia systems to support meaningful activities in dementia care: A systematic review To be published in: Archives of Gerontology and Geriatrics","authors":"Noelia Gerbaudo-González ,&nbsp;Raquel Rodríguez-González ,&nbsp;David Facal-Mayo ,&nbsp;Manuel Gandoy-Crego","doi":"10.1016/j.archger.2024.105575","DOIUrl":"10.1016/j.archger.2024.105575","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>Interactive multimedia systems are widely used to enhance participation in meaningful activities for older people living with dementia. This review aims to analyze and synthesize current evidence regarding personalization of these systems, by considering the type of content included, the selection process and the experience of people living with dementia when interacting with the content.</p></div><div><h3>Materials and Methods</h3><p>In accordance with PRISMA guidelines (PROSPERO registration number blinded for review), a systematic search was undertaken across 4 databases. Meta-aggregation pooled data for synthesis.</p></div><div><h3>Results</h3><p>A total of 520 articles were identified from searches in four databases, and 15 were included in this review. Two classes of content were identified: personal, often autobiographical; and curated, carefully chosen generic content appropriate for a wider group of people in the demographic. Variety of content can act as a trigger for autobiographical memories. Personalized music enhanced a desire to engage and prompted meaningful interactions among participants.</p></div><div><h3>Discussion and Implications</h3><p>Despite some differences in the selected studies, the findings enabled us outline key points to consider when personalizing interactive multimedia systems for people living with dementia. Further research should focus on studying the social condition of the target users during the personalization process and on the benefits for caregivers.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105575"},"PeriodicalIF":3.5,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0167494324002516/pdfft?md5=dbc034811046bdc3becd64d26b6d8c41&pid=1-s2.0-S0167494324002516-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise reshapes aging bodies and minds","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2024.105581","DOIUrl":"10.1016/j.archger.2024.105581","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"126 ","pages":"Article 105581"},"PeriodicalIF":3.5,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates in inspiratory muscle training for older adults: A systematic review","authors":"Elissa Silva de Farias Mello ,&nbsp;André Luiz Musmanno Branco Oliveira ,&nbsp;Thais Dillinger Conway Santanna ,&nbsp;Pedro Paulo da Silva Soares ,&nbsp;Gabriel Dias Rodrigues","doi":"10.1016/j.archger.2024.105579","DOIUrl":"10.1016/j.archger.2024.105579","url":null,"abstract":"<div><p>Systematic reviews support the benefits of inspiratory muscle training (IMT) for exercise performance. Recently, many health benefits from IMT have been reported in older adults. Therefore, this work reviewed the literature focusing on IMT effects beyond physical performance in older adults, such as cardiorespiratory, metabolic, and postural balance outcomes. Searches were conducted with the following terms: (\"respiratory muscle training\" OR \"inspiratory muscle training\") OR (\"inspiratory muscle strength training\") AND (\"elderly\" OR \"older\" OR \"aging\" OR \"aging\"), and using the databases: MEDLINE (PubMed), SCOPUS and EUROPE PMC. Of the 356 articles found, 13 matched the inclusion criteria after screening. Based on reviewed studies, four to eight weeks of IMT (Mostly from 50 % up to 75 % of MIP, 7 days/week) improve cardiac autonomic control at rest and post-exercise, cerebrovascular response to orthostatic stress, static and dynamic balance, blood pressure control, endothelial function, and oxidative stress in older adults. The benefits of IMT in cardiac autonomic and vascular functions are reversed after training cessation. It thus appears that IMT promotes broad physiological gains for the older population. It is necessary to carry out more randomized clinical trials on the subject to confirm the findings of this research.</p></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"127 ","pages":"Article 105579"},"PeriodicalIF":3.5,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}