Archives of gerontology and geriatrics最新文献

{"title":"Associations of serum uric acid-to-high density lipoprotein cholesterol ratio with age-related diseases and mortality among older population in the United States","authors":"Ziqi Chen ,&nbsp;Iokfai Cheang ,&nbsp;Qiang Qu,&nbsp;Xu Zhu,&nbsp;Yiyang Fu,&nbsp;Rongrong Gao,&nbsp;Yanli Zhou,&nbsp;Xinli Li","doi":"10.1016/j.archger.2024.105707","DOIUrl":"10.1016/j.archger.2024.105707","url":null,"abstract":"<div><h3>Background</h3><div>Older adults experience numerous physiological and socioeconomic changes that increase the risk of chronic diseases. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a potential biomarker for assessing various health conditions. This study aimed to investigate the relationship between UHR and the prevalence of age-related diseases and mortality in a nationally representative sample of older adults in the United States.</div></div><div><h3>Methods</h3><div>This retrospective cohort study utilized data from the National Health and Nutrition Examination Surveys (NHANES) 2001–2016 including 17,968 participants aged ≥ 50 years. Mortality data were obtained through the National Death Index (NDI) until December 31, 2019. UHR was calculated by dividing serum uric acid (SUA) by high-density lipoprotein cholesterol (HDL-C). Statistical analyses included Kaplan-Meier, logistic regression models, COX regression, restricted cubic spline (RCS), receiver operating characteristic (ROC), net reclassification index (NRI), integrated discrimination improvement (IDI), and mediation analyses.</div></div><div><h3>Results</h3><div>Significant positive associations were found between UHR levels and the incidence of hypertension, diabetes, chronic kidney disease (CKD), and cardiovascular disease (CVD). Higher UHR levels also correlated with increased cardiovascular and all-cause mortality. Non-linear regressions were observed between UHR and the morbidity of diabetes (<em>p</em> = 0.039), CVD (<em>p</em> = 0.036), all-cause mortality (<em>p</em> = 0.004), with a consistent inflection point at 0.1067478. Subgroup analyses indicated potential effect modifications by gender, BMI, alcohol and drug consumption. UHR outperformed SUA and HDL-C in predicting CVD, as demonstrated by ROC curves and validated by NRI and IDI scores. Mediation analysis indicated that renal impairment partially mediated the link between UHR and all-cause mortality (mediation ratio: 27.39 %).</div></div><div><h3>Conclusion</h3><div>UHR was significantly associated with the incidence of age-related diseases and mortality in adults aged over 50 years. The study provided evidence that UHR may be a more effective predictor of CVD than SUA or HDL-C alone. Our findings highlighted the potential clinical utility of UHR as a diagnostic and prognostic tool in the older population. Further research is required to generalize conclusions and understand underlying mechanisms.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105707"},"PeriodicalIF":3.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining neurocognitive assessment: The essential integration of sensory evaluation","authors":"Joana O. Pinto ,&nbsp;Artemisa R. Dores ,&nbsp;Bruno Peixoto ,&nbsp;Fernando Barbosa","doi":"10.1016/j.archger.2024.105704","DOIUrl":"10.1016/j.archger.2024.105704","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105704"},"PeriodicalIF":3.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study","authors":"Yuze Mi ,&nbsp;Shaokai Lin ,&nbsp;Ke Chen ,&nbsp;Zhendi Shu","doi":"10.1016/j.archger.2024.105706","DOIUrl":"10.1016/j.archger.2024.105706","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is one of the most common and challenging consequences of aging, which negatively affects older adults, their families, and society. Caffeine has been shown to be associated with a reduced risk of frailty by observational studies, yet its causal relationship with frailty remains to be tested using more robust methods.</div></div><div><h3>Aims</h3><div>This study aimed to explore the causal association between plasma caffeine and frailty using a two-sample Mendelian Randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Single nucleotide polymorphisms related to plasma caffeine concentrations were selected as instrumental variables. Data on the Frailty Index (FI) were sourced from the UK Biobank and TwinGen meta-analysis (<em>n</em> = 175,226), while data on the Fried Frailty Score (FFS) were obtained from the UK Biobank (<em>n</em> = 386,565). The causal association between plasma caffeine levels and frailty was tested using five MR methods, with the inverse-variance weighted method as the primary approach.</div></div><div><h3>Results</h3><div>Our results consistently showed significantly negative associations between genetically predicted plasma caffeine with FI (<em>β</em> = -0.050, 95 % CI:0.077 to -0.023, <em>P</em> &lt; 0.001) and FFS (<em>β</em> = -0.049, 95 % CI:0.064 to -0.034, <em>P</em> &lt; 0.001). These results remained robust in further sensitivity analyses using a leave-one-out approach.</div></div><div><h3>Conclusion</h3><div>Our findings confirm a causal relationship between plasma caffeine and frailty and suggest that increasing plasma caffeine levels may help prevent and reduce the risk of frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105706"},"PeriodicalIF":3.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separating neurocognitive mechanisms of maintenance and compensation to support financial ability in middle-aged and older adults: The role of language and the inferior frontal gyrus","authors":"Macarena Suárez-Pellicioni ,&nbsp;Ian M. McDonough","doi":"10.1016/j.archger.2024.105705","DOIUrl":"10.1016/j.archger.2024.105705","url":null,"abstract":"<div><div>This study investigated the role of brain regions involved in arithmetic processing in explaining individual differences in financial ability in 67 50–74-year-old cognitively normal adults. Structural integrity and resting-state functional connectivity measures were collected in the MRI scanner. Outside the scanner, participants performed financial ability and other cognitive tasks, and answered questionnaires to determine dementia risk, and financial risk and protective factors. Regions of interest involved in arithmetic processing were defined, focusing on language- and quantity-processing areas in temporo-frontal and parieto-frontal cortices, respectively. Our results showed that structural integrity and functional connectivity in brain regions associated with arithmetic retrieval were positively associated with financial ability, with language skill mediating left IFG structural integrity and financial ability. Connectivity patterns suggested that reliance on quantity mechanisms (i.e. calculation) was associated with poorer financial ability. Analyses revealed that reliance on these brain mechanisms did not depend on participants’ age or risk of dementia and that protective factors such as household income or financial literacy supported the maintenance of connectivity related to financial abilities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105705"},"PeriodicalIF":3.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined healthy lifestyle behaviors and all-cause mortality risk in middle-aged and older US adults: A longitudinal cohort study","authors":"Luyao Qiao,&nbsp;Yan Wang,&nbsp;Yi Deng,&nbsp;Jiaxing Peng,&nbsp;Yanping Li,&nbsp;Min Li,&nbsp;Zhenyu Tang","doi":"10.1016/j.archger.2024.105702","DOIUrl":"10.1016/j.archger.2024.105702","url":null,"abstract":"<div><h3>Background</h3><div>While various lifestyle behaviors separately or partly have been shown to be associated with health outcomes, including a multitude of diseases and death, none of the earlier research has comprehensively investigated the combined impact of modified lifestyle behaviors. This longitudinal study investigated the association between a composite of healthy lifestyle behaviors and all-cause mortality in middle-aged and older Americans.</div></div><div><h3>Methods</h3><div>We utilized data from the National Health and Nutrition Examination Survey from 2007 to 2018, as well as relevant mortality data, applying the Healthy Lifestyle Score<span><span>¹</span></span> (HLS) index to assess healthy lifestyle behaviors, defined by no smoking, moderate alcohol, appropriate sleep, a balanced diet, adequate physical activity, and limited sedentary time. Weighted multivariate Cox proportional hazards analyses were applied to investigate the associations between these lifestyle practices and overall mortality, followed by stratified analyses to explore potential effect modifications by subgroups.</div></div><div><h3>Results</h3><div>This study included 5448 participants, categorized into unfavorable (28%), intermediate (56%), and favorable (16%) HLS groups. During a median 103-month follow-up, 388 participants died. Cox regression revealed that individuals with favorable lifestyles had a reduced likelihood of death than those with unfavorable lifestyles (HR = 0.49, 95% CI: 0.34–0.70). There was a linear negative relationship established between HLS and the likelihood of all-cause death (<em>p</em> for non-linearity = 0.0512).</div></div><div><h3>Conclusion</h3><div>Adherence to a composite of healthy habits is linearly and substantially related to decreasing the likelihood of all-cause mortality among the elderly in the U.S., highlighting the substantial benefits of maintaining these behaviors for longevity and health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105702"},"PeriodicalIF":3.5,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of comprehensive geriatric assessment and Traditional Chinese Medicine constitution types for integrative geriatric care","authors":"Wan-Ling Lin ,&nbsp;Tun-Pin Hsueh ,&nbsp;Yu-Chun Wang ,&nbsp;Jenn-Tien Chiu ,&nbsp;Ssu-Sheng Yan ,&nbsp;Yu-Fen Wang ,&nbsp;Chih-Kuang Liang ,&nbsp;Ying-Hsin Hsu ,&nbsp;Mei-Chen Liao ,&nbsp;Ming-Yueh Chou","doi":"10.1016/j.archger.2024.105697","DOIUrl":"10.1016/j.archger.2024.105697","url":null,"abstract":"<div><h3>Background</h3><div>Complementary medicine may enhance conventional geriatric care, but clinical guidance for incorporating Traditional Chinese Medicine (TCM) therapies remains limited. This study aimed to investigate the link between TCM body constitutions and comprehensive geriatric assessment scores in older adults.</div></div><div><h3>Method</h3><div>This prospective observational study recruited 100 participants aged 65 and older between January 2020 and December 2021. Each participant underwent comprehensive geriatric assessments, including the Body Constitution Questionnaire, functional tests, and comprehensive geriatric assessment questionnaires evaluating depression, activities of daily living, nutrition, cognition, comorbidities, frailty, and sensory impairments.</div></div><div><h3>Results</h3><div>Increasing age, polypharmacy, and impaired Timed Up and Go Test performance were associated with abnormal TCM body constitutions, while sarcopenia was not. Specific geriatric domains significantly linked to abnormal constitutions included impairments in activities of daily living (ADLs), instrumental ADLs (IADLs), cognitive function, hearing, sleep, and urinary continence (all <em>p</em> &lt; 0.05). Individuals with more than five affected geriatric domains were more likely to exhibit an abnormal constitution. Logistic regression identified sleep disturbances and dependence in ADLs as potential risk factors for developing an abnormal constitution.</div></div><div><h3>Conclusion</h3><div>This study elucidates key geriatric syndrome components linked to abnormal TCM constitutions in older adults, including hearing, sleep, continence, functional and cognitive impairments. Multiple affected geriatric domains increased the likelihood of an abnormal constitution. These findings inform holistic TCM-integrated care by identifying areas for targeted interventions to address constitutional abnormalities and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105697"},"PeriodicalIF":3.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircRSU1 contributes to the development of osteoarthritis via the miR-345-3p/TRAF6 signaling","authors":"Yinan Zhao ,&nbsp;Yingchun Wang ,&nbsp;Mo Li,&nbsp;Zhiquan Li","doi":"10.1016/j.archger.2024.105696","DOIUrl":"10.1016/j.archger.2024.105696","url":null,"abstract":"<div><div>Objective: Osteoarthritis (OA) is a common type of prevalent joint diseases in the elderly. At present, circular RNAs receive more attention due to their roles during the progression of OA. In this paper, the expression profiles of circRSU1 and relevant molecules in OA patients and cell models were evaluated, and the underlying regulatory mechanisms of circRSU1-modulated OA development were also explored. Methods: The proliferation of chondrocytes was examined using CCK-8 assay. The levels of relevant proteins were evaluated by western blotting. The production of pro-inflammatory cytokines were measured by ELISA. Results: The results revealed upregulation of circRSU1 in OA samples, and IL-1β treatment could elevate the expression of circRSU1 in human chondrocytes. In addition, knockdown of circRSU1 abolished the dysfunctions caused by IL-1β in chondrocytes. Furthermore, miR-345–3p was identified as the novel downstream molecule of circRSU1. The levels of miR-345–3p were notably decreased in cells transfected with oe-circRSU1 and elevated in cells treated with si-circRSU1, respectively. Moreover, si-circRSU1 was able to attenuate IL-1β-induced impairments in chondrocyte via miR-345–3p. In addition, to verify the downstream mechanisms of circRSU1-modulated OA progression, TRAF6 was identified as the putative target of miR-345–3p, and miR-345–3p inhibition abolished circRSU1 knockdown-triggered downregulation of TRAF6 in IL-1β-induced OA cell model. In addition, miR-345–3p protected chondrocytes from IL-1β-induced dysfunction such as impaired ECM, reduced proliferation and upregulated apoptosis of chondrocytes, and elevated production of proinflammatory cytokines through regulating TRAF6. Conclusion: In summary, circRSU1 was able to contribute to the progression of OA through regulating the miR-345–3p/TRAF6 pathway, and this novel signalling could be novel candidate for targeted therapy for OA patients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105696"},"PeriodicalIF":3.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of wearable sensors in constructing a fall risk prediction model for community-dwelling older adults: A scoping review","authors":"Bingqing Wang,&nbsp;Yiwen Liu,&nbsp;Aming Lu,&nbsp;Cenyi Wang","doi":"10.1016/j.archger.2024.105689","DOIUrl":"10.1016/j.archger.2024.105689","url":null,"abstract":"<div><h3>Background</h3><div>Falls are a particularly important public health problem among older people. Early identification of risk factors is crucial for reducing the risk of falls in older adults. Studies have confirmed the effectiveness of sensor-based fall risk prediction models for the older population. This article aims to sort out the current use of wearable sensors in building fall risk models for older adults in the community and explore the suitable use of sensors in model construction and the prospects and possible difficulties of model application.</div></div><div><h3>Methods</h3><div>This scoping review was conducted from 26 November 2023 to 9 March 2024. It was searched through Web of Science, PubMed, OVID, EBSCO and CNKI using the terms “wearable sensor” or “inertial sensor” or “inertial motion capture” or “wearable electronic devices” or “IMU” or “MEMS” or “accelerometer” or “gyroscope” or “magnetometer” or “smartphone” and “fall” and “predict” or “prediction” and “older adults” or “older men” or “older women” or “elderly” and “community” or “neighborhood” or “dwelling”.</div></div><div><h3>Results</h3><div>Thirty-one articles were included, and the selection of sensor type, location, and other characteristics and indicators, as well as model types, was summarized.</div></div><div><h3>Discussion and Conclusions</h3><div>Wearable sensors with a frequency of 100 Hz located in a combination of spine/ pelvis/ hip-shank-feet position is recommended. In addition, walking tests and TUG and its variants are appropriate in the community. However, more empirical research is needed to obtain the best model construction combination and apply it effectively to the community.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105689"},"PeriodicalIF":3.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enalapril induces muscle epigenetic changes and contributes to prevent a decline in running capacity in spontaneously hypertensive rats","authors":"Denis Carlos dos Santos ,&nbsp;Fernando Henrique Ferrari Alves ,&nbsp;Luiz Fernando Veríssimo ,&nbsp;Hiviny Ataides Raquel ,&nbsp;Vinicius Lucca Volpini ,&nbsp;Leonardo André da Costa Marques ,&nbsp;Marli Cardoso Martins-Pinge ,&nbsp;Karen Barros Parron Fernandes ,&nbsp;Karoliny Coelho Andrade ,&nbsp;Lisete Compagno Michelini ,&nbsp;Gislaine Garcia Pelosi","doi":"10.1016/j.archger.2024.105699","DOIUrl":"10.1016/j.archger.2024.105699","url":null,"abstract":"<div><div>Drugs such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers can improve muscle function and exercise capacity, as well as preventing, attenuating or reversing age-related losses in muscle mass, however, the exact mechanisms by which these drugs affect muscle cells, are not yet fully elucidated. Moreover, the potential epigenetic alterations induced in skeletal muscle tissue are also largely unexplored. The aim of this study was to evaluate if enalapril or losartan can change the physical performance and epigenetic profile of skeletal muscle in spontaneously hypertensive rats (SHRs). Male SHRs were treated with water, enalapril (10/mg/kg/day) or losartan (10/mg/kg/day) for 28 consecutive days and submitted to progressive testing on a treadmill. Body weight, perigonadal and retroperitoneal fat, mean arterial pressure, heart rate, running distance and global DNA methylation in the gastrocnemius and soleus muscles were evaluated. Enalapril reduced the rate of weight gain, as well as reducing retroperitoneal fat (<em>p</em> &lt; 0.05) and MAP (<em>p</em> &lt; 0.05) and avoiding the decline in running distance when compared to the other groups (<em>p</em> &gt; 0.05), even 7 days after the end of treatment (<em>p</em> &gt; 0.05). Moreover, enalapril increased global DNA methylation in gastrocnemius muscle cells (<em>p</em> &lt; 0.01). No effects were observed in the losartan-treated group. Our data showed that enalapril prevented the decline in physical function in SHR, as well as reduced the rate of weight gain of the animals. In addition, the results showed, alterations in the global DNA methylation of skeletal muscle cells skeletal structures of the gastrocnemius muscle.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105699"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, determinants, and health outcomes of potentially inappropriate medication use according to the 2023 beers criteria among hospitalised older patients","authors":"Kittipak Jenghua ,&nbsp;Sirayut Phatthanasobhon ,&nbsp;Duangkamon Poolpun","doi":"10.1016/j.archger.2024.105693","DOIUrl":"10.1016/j.archger.2024.105693","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to determine the prevalence, determinants, and rehospitalisation outcomes of potentially inappropriate medication (PIM) use among hospitalised older patients.</div></div><div><h3>Design and participants</h3><div>This retrospective cohort study analysed older patients admitted to a tertiary care hospital from 2021 to 2023. We evaluated PIM prescriptions using the 2023 Beers criteria, classifying the patients as PIM users or non-users. We assessed the prevalence of PIM use, identified its determinants, and investigated the association between PIM use and rehospitalisation for any reason within one year of discharge, as well as the related length of stay and total medical costs.</div></div><div><h3>Results</h3><div>The study comprised 20,629 hospitalised older patients with a mean age of 71.17 ± 8.14 years, 50.21% of whom were women. PIM usage was prevalent among 91.32% of the patients. The determinants of PIM use included being female, having a longer hospital stay, an increasing number of prescribed drugs, and three or more chronic conditions. However, the use of PIM did not significantly increase the risk of rehospitalisation (adjusted hazard ratios = 1.02; 95% CI = 0.87–1.19), length of stay (adjusted mean difference [aMD] = 0.35 days; 95% CI = -1.31 to 2.01 days), or cost of medical care (aMD = 2,039 Baht; 95% CI = -9,824 to 13,901 Baht).</div></div><div><h3>Conclusions</h3><div>The use of PIMs among hospitalised older patients remains alarmingly high and is strongly correlated with the number of prescribed drugs. However, no significant link was found between PIM use and rehospitalisation outcomes within a one-year period.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105693"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}