Archives of gerontology and geriatrics最新文献

{"title":"A novel HDAC1-specific inhibitor prevents estrogen deficiency-induced osteoporosis in mice by inhibiting osteoclast function","authors":"Hang Yuan ,&nbsp;Yizhong Bao ,&nbsp;Li Li ,&nbsp;Yepeng Luan ,&nbsp;Fangcai Li","doi":"10.1016/j.archger.2025.106020","DOIUrl":"10.1016/j.archger.2025.106020","url":null,"abstract":"<div><div>Postmenopausal osteoporosis (PMOP) features reduced bone mass and deteriorated bone microstructure, increasing fracture risk. Estrogen deficiency-induced osteoclast overactivation is a primary driver. OCP-001, a novel highly selective HDAC1 inhibitor, was investigated. TRAP staining showed dose-dependent inhibition of osteoclast differentiation by OCP-001. qPCR revealed concomitant downregulation of RANKL-induced osteoclast marker genes (<em>Trap, DC-Stamp, NFATc1, ATP60</em>) and key regulatory proteins (c-Fos, NFATc1, Blimp-1, IRF-8). In an ovariectomized (OVX)-induced PMOP mouse model, body weight monitoring showed no toxicity from OCP-001 treatment. Micro-CT analysis confirmed that it effectively prevented femoral bone mass loss and microstructural deterioration. Histological analysis further verified its inhibition of OVX-induced osteoclastogenesis. Furthermore, OCP-001 normalized OVX-altered serum bone turnover markers (PINP, β-CTx). Mechanistically, OCP-001 suppressed osteoclast differentiation partly via inhibiting the Blimp-1/IRF-8 pathway. Thus, the selective HDAC1 inhibitor OCP-001 alleviates OVX-induced bone loss and deterioration by potently inhibiting osteoclastogenesis and function, supporting its potential as a PMOP therapeutic.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106020"},"PeriodicalIF":3.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding barriers and facilitators to oral health interventions in community-dwelling older adults with cognitive impairment: A scoping review","authors":"Yaqi Huang ,&nbsp;Youran Liu ,&nbsp;Chun Man Wong ,&nbsp;Yaqian Liu ,&nbsp;Juan Chen ,&nbsp;Angela Yee Man Leung","doi":"10.1016/j.archger.2025.106014","DOIUrl":"10.1016/j.archger.2025.106014","url":null,"abstract":"<div><h3>Background</h3><div>Older adults with cognitive impairment face significant challenges in maintaining oral health while the barriers and facilitators for implementing communitybased oral health interventions are uncertain.</div></div><div><h3>Objective</h3><div>To understand the barriers and facilitators for the implementation of oral health intervention among community-dwelling older adults with cognitive impairment.</div></div><div><h3>Methods</h3><div>Literature was searched in PubMed, CINAHL, Embase, PsycINFO, Scopus and Google Scholar. Studies reporting oral health interventions for community-dwelling older adults with cognitive impairment were included. Behaviour Change Techniques (BCTs) were identified and classified using BCT Taxonomy v1. Barriers and facilitators to the implementation were synthesized using thematic analysis.</div></div><div><h3>Results</h3><div>Eleven studies were included. Four types of interventions with 20 distinct BCTs were identified. Facilitators included: 1) Adaptive solutions improved usability and accessibility; 2) Training and guidance enhance the feasibility; 3) The involvement of professionals and care partners ensured the adoption of the new oral hygiene routines; and 4) Participants in earlier stages of cognitive impairment can gradually adjust to new oral care routines. Barriers included: 1) Technique challenges and physical limitations affected participants’ ability to perform correct oral hygiene tasks; 2) Memory decline, emotional distress, and lack of motivation hindered participants' engagement and adherence to oral health practices; 3) Care partners burdens and unmet needs affected consistent support; and 4) Logistical constraints and cultural factors influenced participation and access to oral health interventions.</div></div><div><h3>Conclusions</h3><div>While various interventions have been developed, evidence remains limited. Incorporating user-friendly hygiene techniques, more BCTs, appropriate technical support, caregiver involvement, and oral–cognitive dual-task training were recommended.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106014"},"PeriodicalIF":3.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How social isolation and loneliness leave distinct imprints on memory: a thematic analysis informed by descriptive phenomenology","authors":"Ji Won Kang ,&nbsp;Charity Oga-Omenka ,&nbsp;Suzanne L. Tyas ,&nbsp;Joel A. Dubin ,&nbsp;Mark Oremus","doi":"10.1016/j.archger.2025.106003","DOIUrl":"10.1016/j.archger.2025.106003","url":null,"abstract":"<div><div>With growing recognition of psychosocial risks for cognitive impairment, research on social isolation (SI) and loneliness (LON) and their relationship to memory has increased over the past decade. However, most studies have examined SI and LON separately, leaving their combined influence on memory underexplored, particularly in qualitative research. This study presents the qualitative arm of a larger mixed-methods investigation, exploring how SI and LON, separately and together, shape memory in middle-aged and older adults. Ten individuals aged 47 – 81 were recruited through purposive and snowball sampling for semi-structured interviews, analyzed using thematic analysis informed by descriptive phenomenology. Participants generally viewed LON as more damaging to memory than SI, noting that mental stimulation is still possible during isolation, whereas LON often drains the motivation to engage in such activities. Some described SI positively (form of self-care), though extended SI was seen as detrimental due to increased social anxiety (further limits social engagement), disrupted routines, and diminished sense of purpose, all critical for memory. The combination of SI and LON was perceived as most harmful, creating a feedback loop that exacerbates both conditions and increases vulnerability to self-destructive behaviours (smoking, physical inactivity, poor diet). This research identifies distinctive indicators and psychosocial needs of those experiencing SI, LON, or both, supporting more precise screening and intervention triage in clinical and community settings. It underscores the value of targeted, multimodal brain health interventions addressing diverse contributing factors through strategies like social connection, purpose-driven living, cognitively stimulating activities, chronic disease management, and healthy lifestyle habits.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106003"},"PeriodicalIF":3.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and regional drivers of chronic kidney disease burden in older adults: The dominant role of high fasting plasma glucose and the rise of obesity in China","authors":"Jie Gu ,&nbsp;Huaizhou You","doi":"10.1016/j.archger.2025.106006","DOIUrl":"10.1016/j.archger.2025.106006","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) is a major public health challenge for older adults, increasing global healthcare burdens. However, comprehensive global analyses of long-term trends and regional disparities in CKD burden among older adults are still lacking. To fill this critical gap, we aimed to assess global, regional, and national CKD trends and identify age-specific patterns among adults aged ≥60 years.</div></div><div><h3>Methods</h3><div>Data was obtained from the Global Burden of Disease (GBD) 2021 database. Temporal trends were evaluated via Joinpoint regression to compute average annual percentage changes (AAPC) values. Trends were further disaggregated by age, period, and birth cohort using an age-period-cohort model. The determinants of CKD burden were also explored.</div></div><div><h3>Results</h3><div>In 2021, the global prevalence of CKD in older adults was 296.22 million, with 13.47 million new cases, 1.17 million deaths, and 24.03 million disability-adjusted life years (DALYs)—representing increases of 113 %, 163 %, 177 %, and 208 % respectively since 1992. However, age-standardized prevalence rate (ASPR) slightly declined [AAPC –0.14 (95 % confidence interval:0.15 to –0.14)]. The CKD burden in older adults varied by region and age group, with notable gender disparities. Type 2 diabetes mellitus (T2DM), primarily driven by high fasting plasma glucose, emerged as a leading contributor to DALYs. In addition, high body mass index emerged as a fast-growing, previously under-recognized contributor, particularly in China and middle-SDI regions.</div></div><div><h3>Conclusion</h3><div>Between 1992 and 2021, CKD-related mortality and DALYs among older adults increased significantly worldwide, primarily driven by population growth and T2DM, despite a slight decline in the ASPR.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106006"},"PeriodicalIF":3.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse health outcomes of oral frailty in community-dwelling older adults: a systematic review and meta-analysis","authors":"Pan Li ,&nbsp;Lixia Xie ,&nbsp;Yifan Ou ,&nbsp;Yutong Zhou ,&nbsp;Wen Zhang ,&nbsp;Yao Chen ,&nbsp;Yijie Fang ,&nbsp;Xinhong Yin","doi":"10.1016/j.archger.2025.106004","DOIUrl":"10.1016/j.archger.2025.106004","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral frailty(OF) is a comprehensive manifestation of impaired chewing, swallowing, and oral function in older adults, and is associated with adverse health outcomes such as malnutrition, physical frailty, and falls. This study analyzes the association between OF and adverse health outcomes in community-dwelling older adults to provide insights for improving their quality of life.</div></div><div><h3>Methods</h3><div>A literature search was conducted in PubMed, Web of Science, The Cochrane Library, Embase, and Scopus databases to identify studies related to OF in community-dwelling older adults and their adverse health outcomes. The search was limited to studies published from the inception of each database up to May 31, 2025. The focus was on studies involving community-dwelling older adults aged 60 years and older, adverse health outcomes associated with OF, and studies employing cross-sectional or cohort study designs.</div></div><div><h3>Results</h3><div>A review of 23 studies involving 27,585 participants found that OF in community-dwelling older adults was associated with physical frailty (OR = 1.78, 95% CI: 1.19, 2.68), sarcopenia (OR = 2.01, 95% CI: 1.64, 2.47), falls (OR = 1.58, 95% CI: 1.37, 1.82), high oral microbial counts (OR = 3.05, 95% CI: 1.35, 6.88), malnutrition (OR=2.18, 95% CI: 1.63, 2.92), and low dietary diversity (OR=1.98, 95% CI: 1.15, 3.39).</div></div><div><h3>Conclusion</h3><div>There is an association between OF and adverse health outcomes in community-dwelling older adults. Investigating the relationship between OF and adverse health outcomes in community-dwelling older adults is of great significance for improving the quality of life of older adults and promoting healthy longevity.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106004"},"PeriodicalIF":3.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing exercise dosage for executive function in alzheimer’s disease: A Bayesian dose-response meta-analysis of randomized trials","authors":"Sihong Sui ,&nbsp;Mingyi Wang","doi":"10.1016/j.archger.2025.106001","DOIUrl":"10.1016/j.archger.2025.106001","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to identify the optimal dose range of physical exercise for improving executive function in individuals with Alzheimer’s disease (AD) and to compare the dose-dependent cognitive response profiles across different exercise modalities.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted across five databases-PubMed, Embase, Cochrane Library, SPORTDiscus, and Web of Science-up to June 20, 2025, with no language restrictions. All analyses were performed in R (version 4.4.2). A Bayesian framework was used to model continuous dose-response curves and to evaluate the relative effects of aerobic training, integrated physical training, and resistance exercise within a network structure.</div></div><div><h3>Results</h3><div>Exercise interventions demonstrated a nonlinear relationship with executive function, with the strongest effect observed at approximately 1000 MET-min/week. Among exercise types, continuous aerobic training showed significant improvement at 670 MET-min/week, indicating a relatively low-dose threshold for benefit. In contrast, integrated physical training programs required higher doses (around 1200 MET-min/week) to reach peak effect, suggesting greater intensity dependence. Resistance training did not yield consistent or statistically significant outcomes across the tested dose levels.</div></div><div><h3>Conclusion</h3><div>This study establishes a quantitative framework that integrates dose modeling with intervention structure to guide exercise-based cognitive strategies for AD. The findings emphasize the need to match exercise volume to modality demands and individual capacity, supporting the development of precision-oriented, non-pharmacological interventions. The identified optimal range (670–1200 MET-min/week) aligns with WHO recommendations for older adults, reinforcing both feasibility and translational potential.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106001"},"PeriodicalIF":3.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing palliative care needs and medication appropriateness: Initiation and reinitiation of medications at the end of life","authors":"Degefaye Zelalem Anlay ,&nbsp;Kristel Paque ,&nbsp;Astrid D.H. Brys ,&nbsp;Joachim Cohen ,&nbsp;Tinne Dilles","doi":"10.1016/j.archger.2025.105994","DOIUrl":"10.1016/j.archger.2025.105994","url":null,"abstract":"<div><h3>Background</h3><div>Medications deemed inappropriate and discontinued in the earlier stages of life-limiting disease may become relevant in palliative care context at the end of life. This study aims to determine the incidence of and factors associated with initiation and reinitiation of medications deemed inappropriate according to the STOPPFrail guideline.</div></div><div><h3>Methods</h3><div>A retrospective cohort study using linked healthcare reimbursement data. We included nursing home residents aged ≥65 who died with a condition potentially amenable to palliative care between 2015 and 2019 in Belgium. Outcomes were: (1) reinitiation of previously discontinued STOPPFrail-listed medications; and (2) initiation of these medications, regardless of prior use, in the last three months. Log-binomial regression was used to estimate relative risks (RR) with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>Among 158,689 decedents, 29.7 % had at least one medication initiated, and 16.96 % reinitiated among those with at least one medication discontinued (<em>n</em> = 13,724). By medication type, initiation and reinitiation were significantly higher for symptomatic medications than preventive ones (initiation: 25.5 % symptomatic vs. 6.7 % preventive; reinitiation: 20.3 % symptomatic vs. 11 % preventive). The risk was higher among residents with cancer, who were hospitalized, or taking ≥10 chronic medications.</div></div><div><h3>Conclusions</h3><div>A significant proportion of residents undergo initiation or reinitiation of medications deemed inappropriate at the end of life per existing guidelines. Many were likely prescribed for palliative purposes. Thus, guidelines on medication appropriateness may need to more explicitly address palliative care contexts. A notable number also received preventive medications, suggesting inappropriate prescribing at the end of life that has received little attention.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 105994"},"PeriodicalIF":3.8,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive validity of senior volunteer-led frailty check-up results for disability and mortality among community-dwelling older adults: a cohort study","authors":"Tomoki Tanaka ,&nbsp;Weida Lyu ,&nbsp;Yasuyo Yoshizawa ,&nbsp;Bo-Kyung Son ,&nbsp;Katsuya Iijima","doi":"10.1016/j.archger.2025.105998","DOIUrl":"10.1016/j.archger.2025.105998","url":null,"abstract":"<div><div>A frailty checkup program (FC), a community-based frailty prevention initiative led by trained senior volunteers (FC supporters), has been implemented in over 100 municipalities in Japan. Participants create individual result sheets by marking blue signals for positive responses and red signals for negative responses. This cohort study aimed to examine the association between FC results and the risk of incident disability and mortality among community-dwelling older adults. A total of 3476 older adults (mean age, 73.0 ± 6.1 years, 74 % female) participated in FC in three municipalities between April 2017 and February 2023. At the FC sites, trained supporters evaluated 22 FC items (nutritional status, oral function, physical function, and social status). Outcome information on long-term care needs (incident disability) and mortality was collected from public records until November 2023. During the follow-up (median, 1088 days), 254 participants (7.3 %) developed incident disabilities, and 138 (4.0 %) died. A higher total number of red signals was associated with increased risk; individuals with ≥8 red signals had an increased risk of incident disability (adjusted hazard ratio [95 % confidence interval], 2.93 [2.08–4.12]). We calculated a weighted predictive probability using eight items particularly associated with increased risk of disability and mortality (5.39 [3.82–7.61], 1.94 [1.11–3.40], respectively, in the high-risk group). FC results in community-dwelling older adults were associated with a higher risk of incident disability and mortality. This study highlights the potential of the FC program in identifying high-risk individuals and guiding them to appropriate community-based interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 105998"},"PeriodicalIF":3.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor. Tackling social frailty: The role of family and community nurses","authors":"Yari Longobucco ,&nbsp;Khadija El Aoufy","doi":"10.1016/j.archger.2025.105989","DOIUrl":"10.1016/j.archger.2025.105989","url":null,"abstract":"<div><div>This letter commends the recent concept analysis of social frailty in older adults by Pradana et al., emphasizing its value as a framework for understanding and addressing an often-overlooked aspect of geriatric vulnerability. The authors’ identification of four antecedent domains—lifestyle, social and environmental factors, medical services, and health conditions—provides a practical scaffold for targeted interventions. Within this context, Family and Community Nurses (FCNs) are uniquely positioned to mitigate the onset and progression of social frailty through their longitudinal, holistic, and preventive role in community-based care. We highlight the need to translate conceptual antecedents into actionable strategies. FCNs can operationalize preventive measures such as home-based health promotion, motivational interviewing, and early frailty screening during home visits. By addressing lifestyle risk factors, enhancing social connections, and facilitating access to services, FCNs convert abstract determinants into individualized care plans. Their work extends to fostering community engagement, coordinating interdisciplinary collaboration, and leveraging local resources to reduce isolation and environmental deprivation. The letter underscores the value of FCNs as care coordinators within interprofessional teams, integrating health and social interventions to optimize continuity of care. In addition, telenursing emerges as an effective complement, particularly for underserved or rural populations, enabling sustained health monitoring and psychosocial support. While challenges such as workforce capacity and training must be addressed, the integration of FCNs into community-based aging programs is increasingly urgent in light of aging populations and pandemic-related exacerbations of social frailty. Grounding FCN-led practice in the identified domains can improve quality of life, resilience, and aging-in-place capacity. Policymakers are urged to embed and strengthen this role within community health systems to transform the theoretical construct of social frailty into measurable, population-level improvements.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 105989"},"PeriodicalIF":3.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a combined intervention of music-based movement, neuromodulation-synchronized cognitive training, and emotion regulation on cognitive function in community-dwelling older adults: A randomized controlled trial","authors":"Chifen Ma ,&nbsp;Chao Wu","doi":"10.1016/j.archger.2025.106000","DOIUrl":"10.1016/j.archger.2025.106000","url":null,"abstract":"<div><h3>Background</h3><div>To enhance cognitive intervention effectiveness, we developed MMNCE—integrating music-based exercise, multi-domain cognitive training with neurostimulation, and emotion-regulation education—grounded in cognitive aging theories.</div></div><div><h3>Methods</h3><div>In this three-arm RCT, we compared MMNCE with cognitive training plus sham neurostimulation (MCS) and a non-intervention control (NIC) among cognitively healthy (CH) and cognitively impaired (CI) older adults. A total of 166 participants (mean age: 68.95 ± 6.27; 70 CI) from community centers in Xuzhou, China, were randomized. Cognitive outcomes (MoCA and executive function) were assessed at baseline, 12, 24, and 36 weeks.</div></div><div><h3>Results</h3><div>At 12 weeks, 124 participants completed the intervention. Independent of the baseline cognitive status, compared to NIC, MMNCE showed larger effect sizes than MCS, with significant improvements in MoCA total scores and domains, including visuospatial ability, naming, attention, abstract reasoning, and episodic memory (η²_p = 0.15 to 0.54). MMNCE outperformed MCS on global cognition and abstraction (MoCA total η²p = 0.07, 95% CI: [0.01, 0.18]; abstraction η²p = 0.11, 95% CI: [0.03, 1]). Compared to MCS, MMNCE had a greater impact on global cognition in CH participants (η²_p = 0.11) while on abstraction in the CI group (η²_p = 0.19). In addition, MMNCE had sustained effects on global cognition. MMNCE also improved physical function and reduced depressive symptoms after intervention, which were not observed in the MCS group.</div></div><div><h3>Conclusions</h3><div>This study highlights MMNCE as an effective nonpharmacological intervention for preserving cognitive function in older adults. Further research is warranted to explore its impact on individuals across various stages of cognitive decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"139 ","pages":"Article 106000"},"PeriodicalIF":3.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}