Archives of gerontology and geriatrics最新文献

{"title":"Enhancing vision and well-being: eyewear design opportunities for older adults","authors":"Yu-Hsiu Hung ,&nbsp;Wan Zi Lin ,&nbsp;Chih Ming Chen","doi":"10.1016/j.archger.2025.105895","DOIUrl":"10.1016/j.archger.2025.105895","url":null,"abstract":"<div><div>The contemporary society emphasizes the need to prioritize the well-being and independence of older adults. Vision, which constitutes 70–80 % of human perception and interaction with the external world, is of particular significance. However, age-related vision problems present substantial challenges that impact their quality of life. The study aims to comprehensively understand the visual issues affecting older adults, pinpoint gaps in the current market for eyewear tailored to their needs, and propose opportunities for future eyewear design specifically for this demographic to enhance their daily experiences. The study encompasses an extensive literature review, a Visual Activities Questionnaire (VAQ) survey to evaluate daily vision-related issues, an analysis of existing eyewear products to identify market deficiencies, and in-depth interviews with older adults to gain nuanced insights. The findings offer potential guidance for the development of visual-assistance products for older adults and serve as a valuable resource for related research.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105895"},"PeriodicalIF":3.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between self-neglect and incident cognitive impairment among Chinese older adults and its subgroup differences","authors":"Yaqi Wang ,&nbsp;Bowen Wan ,&nbsp;Xueying Xu ,&nbsp;Qingyun Lv ,&nbsp;Yuan He ,&nbsp;Jingwen Liu ,&nbsp;Hairong Chang ,&nbsp;Yue Zhao ,&nbsp;Li Fu ,&nbsp;Xiaoying Zang ,&nbsp;Xiaonan Zhang","doi":"10.1016/j.archger.2025.105893","DOIUrl":"10.1016/j.archger.2025.105893","url":null,"abstract":"<div><h3>Background</h3><div>Population aging has led to growing concerns regarding self-neglect and cognitive impairment among older adults. However, research on the association between self-neglect and incident cognitive impairment remains limited. We aimed to investigate the association between self-neglect and incident cognitive impairment and variations in gender and age.</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted involving 2595 Chinese older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) database. Self-neglect was assessed using 17 items from the CLHLS, and cognitive function was evaluated using the Mini-Mental State Examination. Participants with cognitive impairment at baseline were excluded, and incident cognitive impairment during the follow-up period was documented. Cox proportional hazards models, restrictive cubic spline analysis (RCS), and stratified analyses based on gender and age (with 80 as the threshold) were conducted.</div></div><div><h3>Results</h3><div>The study sample comprised 1249 (48.1 %) men and 1346 (51.9 %) women, with an mean age of 79.7 ± 9.8 years. The risk of cognitive impairment was significantly higher for those in the third (Q3) and fourth (Q4) quartiles of self-neglect scores compared to those in the first quartile (Q1). The RCS analysis indicated a significantly linear relationship. The interaction between gender and self-neglect scores was significantly associated with incident cognitive impairment (<em>P</em> for interaction &lt;0.001), suggesting that men are at a higher risk compared to women.</div></div><div><h3>Conclusion</h3><div>Self-neglect is identified as a significant risk factor for incident cognitive impairment among older adults, with a particular impact on men, highlighting the critical need to address self-neglect to prevent cognitive decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105893"},"PeriodicalIF":3.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale and study design of multicomponent exercise intervention for frail older patients with acutely decompensated heart failure: Pilot of the randomized controlled trial J REHAB-HF trial","authors":"Yuji Kono ,&nbsp;Nobuaki Hamazaki ,&nbsp;Satoshi Katano ,&nbsp;Shuhei Yamamoto ,&nbsp;Kodai Ishihara ,&nbsp;Kotaro Iwatsu ,&nbsp;Masatsugu Okamura ,&nbsp;Masato Ogawa ,&nbsp;Ken-ichi Kasai ,&nbsp;Masashi Takeuchi ,&nbsp;Kohei Nozaki ,&nbsp;Masashi Yamashita ,&nbsp;Satoshi Yamamoto ,&nbsp;Shohei Yamamoto ,&nbsp;Kentaro Kamiya ,&nbsp;Tetsuya Takahashi ,&nbsp;Hideo Izawa ,&nbsp;Yohei Otaka","doi":"10.1016/j.archger.2025.105892","DOIUrl":"10.1016/j.archger.2025.105892","url":null,"abstract":"<div><h3>Background</h3><div>In Japan, a growing number of older adults with heart failure (HF) are experiencing physical frailty. Healthcare providers recommend multicomponent exercise program for frail patients; however, their effectiveness in older Japanese adults with HF, who differ physiologically from their Western counterparts, remains unclear. In this study, we will compare the feasibility and efficacy of a multicomponent exercise program with those of conventional exercise therapy as pilot study of the randomized controlled trial, Japanese REHAB-HF (J REHAB-HF) trial.</div></div><div><h3>Methods</h3><div>In this multicenter study, frail older adults hospitalized with worsening HF will be randomly assigned to participate in a program of either multicomponent or conventional exercise therapy. We developed a multicomponent exercise program to target characteristics of physical frailty: poor gait performance, balance ability, muscle strength, and exercise tolerance. The primary outcome is the total score on the Short Physical Performance Battery; additional outcome measures include feasibility and safety of the programs.</div></div><div><h3>Conclusion</h3><div>The pilot study of the J REHAB-HF trial is an evaluation of whether a multicomponent exercise program enhances physical function more effectively than does conventional exercise therapy in frail older adults with HF. The findings will guide the design of the main J REHAB-HF trial and improve care for these individuals.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105892"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training vs. moderate-intensity continuous training on arterial stiffness in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Ping Luo ,&nbsp;Mingxuan Huang ,&nbsp;Yufang Ye ,&nbsp;Ruixue Wang ,&nbsp;Weiyi Yan ,&nbsp;Lin Zhu ,&nbsp;Shanqi Liu ,&nbsp;Yao Tang ,&nbsp;Kang Liu ,&nbsp;Weifeng Gao","doi":"10.1016/j.archger.2025.105890","DOIUrl":"10.1016/j.archger.2025.105890","url":null,"abstract":"<div><h3>Objective</h3><div>Arterial stiffness (AS) is regarded as an independent predictor of cardiovascular events and all-cause mortality, and it is significantly associated with global mortality rates. Physical activity (PA) plays a positive role in reducing AS and improving cardiovascular health. The aim of this study is to compare the differences between high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in their effects on reducing AS.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search of the PubMed, Cochrane, Embase, Web of Science, and EBSCO electronic databases, covering the period from their inception to January 10, 2025. We used a fixed-effect model to compare the changes in pulse wave velocity (PWV) before and after intervention between the HIIT group and the MICT group. Data were reported using the weighted mean difference (WMD) and 95 % confidence interval (95 % CI).</div></div><div><h3>Results</h3><div>This study included 619 participants from 22 studies. Compared to MICT, HIIT demonstrated a more significant reduction in PWV (-0.10 m/s [95 % CI:0.16 to -0.03], <em>P</em> = 0.005). Additionally, we found that HIIT was superior in reducing CF-PWV (-0.10 m/s [95 % CI:0.17 to -0.02], <em>P</em> = 0.01).</div></div><div><h3>Conclusion</h3><div>HIIT is more effective than MICT in improving PWV and promoting arterial health in adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105890"},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynapenic abdominal obesity and chronic kidney disease: Results from a nationwide prospective cohort study of middle-aged and older adults in China","authors":"Zhipeng Chen,&nbsp;Feng Zhao,&nbsp;Siqi Li","doi":"10.1016/j.archger.2025.105879","DOIUrl":"10.1016/j.archger.2025.105879","url":null,"abstract":"<div><h3>Introduction</h3><div>The relationship between dynapenic abdominal obesity (D/AO) and chronic kidney disease (CKD) remains underexplored, particularly among Chinese middle-aged and older adults. This study aimed to address this gap by examining the association between these conditions in a specific population.</div></div><div><h3>Method</h3><div>We conducted a prospective analysis utilizing two waves (2011 and 2015) of data from 5932 participants aged ≥45 years in the China Health and Retirement Longitudinal Study (CHARLS). Three logistic regression models with covariate adjustment were employed to examine the longitudinal association between D/AO and CKD progression. To strengthen the validity of our results, rigorous sensitivity analyses and subgroup analyses were systematically conducted to assess the robustness of the observed primary association between D/AO and CKD.</div></div><div><h3>Results</h3><div>After adjusting for all covariates, D/AO was associated with a significantly increased risk of CKD (OR, 1.57; 95 % CI, 1.03–2.35). In the subgroup analyses, middle-aged adults with D/AO exhibited a significantly higher incidence of CKD, while showing no significant difference in older populations. Subgroup analyses revealed middle-aged adults with D/AO was associated with a significantly increased risk of CKD (OR, 2.40; 95 % CI, 1.14–4.59; <em>p</em> = 0.01), whereas older adults showed no statistically significant association (OR, 1.56; 95 % CI, 0.96–2.46; <em>p</em> = 0.06).</div></div><div><h3>Conclusion</h3><div>This prospective cohort study demonstrates that D/AO conferred elevated CKD risk in Chinese middle-aged adults, while showing no significant association in older populations. These findings highlight the need for interventions aimed at improving muscle strength and reducing abdominal adiposity in CKD prevention strategies and public health policies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105879"},"PeriodicalIF":3.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study","authors":"Mizhgan Fatima ,&nbsp;Ben Kirk ,&nbsp;Sara Vogrin ,&nbsp;Wei-Ju Lee ,&nbsp;Li-Ning Peng ,&nbsp;Liang-Kung Chen ,&nbsp;Gustavo Duque","doi":"10.1016/j.archger.2025.105888","DOIUrl":"10.1016/j.archger.2025.105888","url":null,"abstract":"<div><h3>Background</h3><div>Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk.</div></div><div><h3>Objectives</h3><div>To investigate if osteosarcopenia is associated with frailty risk in community-dwelling older adults.</div></div><div><h3>Design</h3><div>Retrospective analysis of a prospective cohort study.</div></div><div><h3>Setting</h3><div>I–Lan Longitudinal Aging Study (ILAS).</div></div><div><h3>Participants</h3><div>1779 older adults (≥50 years) at baseline, and 998 participants at follow-up.</div></div><div><h3>Measurements</h3><div>Frailty was defined based on the Fried criteria. Osteosarcopenia was defined by the coexistence of osteopenia or osteoporosis (WHO definition) and sarcopenia (Asian Working Group definition). Multinomial logistic regression models were employed to examine the association of osteosarcopenia (at baseline) with frailty risk (at eight years), adjusted for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Out of 1779 adults (mean age 63.9 ± 9.2 SD, women 53.1 %), 998 (mean age 67.1 ± 7.6 SD, women 52.6 %) completed a follow-up at eight years. At baseline, osteosarcopenia was more prevalent in the frail group (27.5 %) compared to the pre-frail (10.8 %) and non-frail groups (0 %). However, neither osteosarcopenia (Odds Ratio [OR] 2.67, 95 %CI 0.85–8.40, <em>p</em> = 0.094) nor its components (sarcopenia (OR 3.13, 95 %CI 0.64–15.21, <em>p</em> = 0.158); osteopenia (OR 1.33, 95 %CI 0.70–2.53, <em>p</em> = 0.386); osteoporosis (OR 1.71, 95 %CI 0.64–4.59, <em>p</em> = 0.287)) were associated with frailty risk at eight years.</div></div><div><h3>Conclusion</h3><div>Neither osteosarcopenia nor its components were associated with frailty risk. However, a greater number of older adults with osteosarcopenia and extended follow-up are needed to re-evaluate whether osteosarcopenia is associated with frailty risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105888"},"PeriodicalIF":3.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional relationship between diabetes and frailty in middle-aged and older adults: A systematic review and meta-analysis","authors":"Huaxin Si ,&nbsp;Yiran Zhang ,&nbsp;Peng Zhao ,&nbsp;Na Li ,&nbsp;Wendie Zhou ,&nbsp;Yemin Yuan ,&nbsp;Ping He ,&nbsp;Cuili Wang","doi":"10.1016/j.archger.2025.105880","DOIUrl":"10.1016/j.archger.2025.105880","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes and frailty are prevalent and burdensome in middle-aged and older adults. However, current evidence on their association is inconsistent, and no quantitative meta-analysis exists. We conducted a systematic review and meta-analysis to examine whether diabetes increased the risk of frailty and vice versa.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Web of Science, Embase, and CINAHL databases from inception to 10 April 2025. Random-effects models were used to calculate pooled odds ratio (OR) and 95 % confidence interval (CI) for cross-sectional analysis and pooled relative risk (RR) for longitudinal analysis. The certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.</div></div><div><h3>Results</h3><div>From 8559 non-duplicated records, 31 articles were included. People with diabetes had increased risks of prevalent frailty (OR=2.21, 95 %CI: 1.60–3.06, I²=99.0 %, n = 15; GRADE=Low), prevalent pre-frailty (OR=2.23, 95 %CI: 2.19–2.28, I²=0.0 %, n = 2; GRADE=Very low), and incident frailty (RR=1.50, 95 %CI: 1.36–1.65, I²=0.0 %, n = 7; GRADE=Moderate). Those with pre-frailty (OR=1.95, 95 %CI: 1.61–2.36, I²=0.0 %; GRADE=Very low) but not with frailty (OR=2.28, 95 %CI:0.96–5.46, I²=92.3 %; GRADE=Very low) had increased odds of prevalent diabetes in two studies. In 15 studies, the pooled RRs for incident diabetes were 1.47 (95 %CI: 1.37–1.57, I²=91.0 %; GRADE=Moderate) in pre-frail participants and 1.96 (95 %CI: 1.73–2.23, I²=92.7 %; GRADE=Moderate) in frail participants.</div></div><div><h3>Conclusion</h3><div>Our findings support the bidirectional relationship between diabetes and frailty in middle-aged and older adults, with each condition contributing to the development of the other. This highlights the importance of early detection and integrated management strategies for diabetes and frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105880"},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and intrinsic capacity in older adults: A systematic review","authors":"Weslley Barbosa Sales ,&nbsp;Paulo Vitor de Souza Silva ,&nbsp;Bianca Stephany Barbosa Vital ,&nbsp;Marcyo Câmara","doi":"10.1016/j.archger.2025.105875","DOIUrl":"10.1016/j.archger.2025.105875","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia and intrinsic capacity are closely linked factors that impact the health and functional aging of older adults.</div></div><div><h3>Objective</h3><div>This systematic review aims to investigate the associations between the domains of IC and sarcopenia in older adults.</div></div><div><h3>Material and methods</h3><div>The study follows PRISMA guidelines and is registered on PROSPERO. The review included original studies (cohort, cross-sectional, or randomized controlled trials) with participants aged 60+ diagnosed with sarcopenia (based on EWGSOP or other recognized definitions). Intrinsic capacity (IC) was assessed based on the five domains defined within the IC framework—cognition, locomotion, sensory, psychological, and vitality. The Integrated Care for Older People (ICOPE) approach developed by the World Health Organization supports the optimization of IC and functional ability through person-centred and coordinated care. Exclusion criteria included studies with insufficient data on sarcopenia prevalence and IC scores, as well as reviews or studies unrelated to sarcopenia or IC.</div></div><div><h3>Results</h3><div>A total of 397 articles were identified, with 5 meeting the inclusion criteria. These studies, involving 6651 participants aged 60 to 82 years (54.8 % male, 45.2 % female), examined the association between sarcopenia and intrinsic capacity in older adults, using the diagnostic criteria for sarcopenia proposed by the EWGSOP and assessing IC based on its key components. Despite the limited number of studies, the findings suggest a significant link between declining intrinsic capacity and sarcopenia.</div></div><div><h3>Final considerations</h3><div>These results underscore the importance of a multifactorial approach in assessing and managing sarcopenia, which may improve early detection and support healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105875"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between aging, ferroptosis, and common age-related diseases","authors":"Laleh Mavaddatiyan ,&nbsp;SaghiHakimi Naeini ,&nbsp;Sara Khodabandeh ,&nbsp;Fatemeh Hosseini ,&nbsp;RhysJ.P. Skelton ,&nbsp;Vahid Azizi ,&nbsp;Mahmood Talkhabi","doi":"10.1016/j.archger.2025.105877","DOIUrl":"10.1016/j.archger.2025.105877","url":null,"abstract":"<div><div>Aging is a natural biological process that is characterized by the progressive decline in physiological functions and an increased vulnerability to age-related diseases. The aging process is driven by different cell and molecular mechanisms. It has recently been shown that aging is associated with heightened vulnerability to ferroptosis (an intracellular iron-dependent form of programmed cell death). This susceptibility arises from various factors including oxidative stress, impaired antioxidant defences, and dysregulated iron homeostasis. The progressive decline in cellular antioxidant capacity and the accumulation of damaged components contribute to the increased susceptibility of aging cells to ferroptosis. Dysregulation of key regulators involved in ferroptosis, such as glutathione peroxidase 4 (GPX4), iron regulatory proteins, and lipid metabolism enzymes, further exacerbates this vulnerability. The decline in cellular defence mechanisms against ferroptosis during aging contributes to the accumulation of damaged cells and tissues, ultimately resulting in the manifestation of age-related diseases. Understanding the intricate relevance between aging and ferroptosis holds significant potential for developing strategies to counteract the detrimental effects of aging and age-related diseases. This will subsequently act to mitigate the negative consequences of aging and improving overall health in the elderly population. This review aims to clarify the relationship between aging and ferroptosis, and explores the underlying mechanisms and implications for age-related disorders, including neurodegenerative, cardiovascular, and neoplastic diseases. We also discuss the accumulating evidence suggesting that the imbalance of redox homeostasis and perturbations in iron metabolism contribute to the age-associated vulnerability to ferroptosis.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105877"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between physical activity trajectories and cognitive function in women 50 years and older: A nationally representative cohort study from the China Health and Retirement Longitudinal Study","authors":"Dehua Gong,&nbsp;Seung-Soo Baek","doi":"10.1016/j.archger.2025.105876","DOIUrl":"10.1016/j.archger.2025.105876","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the longitudinal association between physical activity trajectory changes and cognitive function in women aged 50 years and older.</div></div><div><h3>Methods</h3><div>Data were obtained from the China Health and Retirement Longitudinal Study, collected between 2011 and 2020, involving 2,760 women aged 50 years and older. Group-based trajectory modeling was used to identify four physical activity trajectory groups: Low-Fluctuation Group, Moderate-Increasing Group, Moderate-Stability Group, and High-Fluctuation Group. Cognitive function was assessed based on episodic memory and mental intactness. Linear mixed-effects models were employed to examine the association between physical activity trajectories and cognitive function, including interaction effects and age-stratified analyses.</div></div><div><h3>Results</h3><div>The Moderate-Increasing group was significantly associated with higher levels of global cognitive function (β = 0.45, 95% CI: 0.05–0.85) and episodic memory (β = 0.21, 95% CI: 0.05–0.37), particularly among women aged 50–59 years. In contrast, High-Fluctuation and Low-Fluctuation groups exhibited declining trends across cognitive outcomes. Age-stratified analysis suggested that the association between Moderate-Increasing group and cognitive function was not significant among women aged 60 years and older.</div></div><div><h3>Conclusion</h3><div>In women aged 50–59 years, the Moderate-Increasing group was significantly associated with better global cognitive function and episodic memory; however, this association was attenuated or not observed in older age groups.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105876"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}