Archives of gerontology and geriatrics最新文献

{"title":"Prevalence, determinants, and health outcomes of potentially inappropriate medication use according to the 2023 beers criteria among hospitalised older patients","authors":"Kittipak Jenghua ,&nbsp;Sirayut Phatthanasobhon ,&nbsp;Duangkamon Poolpun","doi":"10.1016/j.archger.2024.105693","DOIUrl":"10.1016/j.archger.2024.105693","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to determine the prevalence, determinants, and rehospitalisation outcomes of potentially inappropriate medication (PIM) use among hospitalised older patients.</div></div><div><h3>Design and participants</h3><div>This retrospective cohort study analysed older patients admitted to a tertiary care hospital from 2021 to 2023. We evaluated PIM prescriptions using the 2023 Beers criteria, classifying the patients as PIM users or non-users. We assessed the prevalence of PIM use, identified its determinants, and investigated the association between PIM use and rehospitalisation for any reason within one year of discharge, as well as the related length of stay and total medical costs.</div></div><div><h3>Results</h3><div>The study comprised 20,629 hospitalised older patients with a mean age of 71.17 ± 8.14 years, 50.21% of whom were women. PIM usage was prevalent among 91.32% of the patients. The determinants of PIM use included being female, having a longer hospital stay, an increasing number of prescribed drugs, and three or more chronic conditions. However, the use of PIM did not significantly increase the risk of rehospitalisation (adjusted hazard ratios = 1.02; 95% CI = 0.87–1.19), length of stay (adjusted mean difference [aMD] = 0.35 days; 95% CI = -1.31 to 2.01 days), or cost of medical care (aMD = 2,039 Baht; 95% CI = -9,824 to 13,901 Baht).</div></div><div><h3>Conclusions</h3><div>The use of PIMs among hospitalised older patients remains alarmingly high and is strongly correlated with the number of prescribed drugs. However, no significant link was found between PIM use and rehospitalisation outcomes within a one-year period.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105693"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular mechanisms of steroid hormone effects on cognitive function","authors":"Hai Duc Nguyen ,&nbsp;Giang Huong Vu ,&nbsp;Woong-Ki Kim","doi":"10.1016/j.archger.2024.105684","DOIUrl":"10.1016/j.archger.2024.105684","url":null,"abstract":"<div><h3>Objective</h3><div>There is a lack of information on the molecular mechanisms by which steroid hormones (testosterone, estrogen, and progesterone) regulate cognitive impairment. Thus, we aimed to identify the protective effects of steroid hormones on cognitive function.</div></div><div><h3>Methods</h3><div>We analyzed the literature on the molecular mechanisms, biological activities, physicochemical properties, and pharmacokinetics of steroid hormones.</div></div><div><h3>Results</h3><div>Steroid hormones can protect against cognitive impairment by regulating key genes (INS, TNF, STAT3, ESR1). Specific microRNAs, namely hsa-miR-335-5p, hsa-miR-16-5p, and hsa-miR-26b-5p, along with transcription factors NFKB1, PPARG, NR3C1, GATA2, EGR1, ATF3, and CEBPA, play a significant role in this protective mechanism. The involvement in cognitive processes, regulation of phosphorylation, neuronal apoptosis, and signaling pathways related to Alzheimer's disease significantly influence the protein-protein interaction network underlying these effects. Additionally, steroid hormones exhibit anti-hypercholesterolemic properties, anti-inflammatory activity, antitoxic properties, and function as inhibitors of acetylcholine neuromuscular transmission. They also hold promise as therapeutic agents for the treatment of dementia. Promising therapeutic interventions for cognitive impairment include the use of miRNA sponges targeting hsa-miR-16-5p, along with the administration of capsaicin, minocycline, dopamine, sertraline, and minaprine. The gut microbiota species <em>Lactobacillus amylovorus, Paraprevotella clara, Libanicoccus massiliensis, Prevotella oris, Turicibacter sanguinis</em>, and <em>Dubosiella newyorkensis</em> were identified as significant contributors to cognitive impairment and altered levels of steroid hormones.</div></div><div><h3>Conclusion</h3><div>Steroid hormones are promising compounds for improving cognitive function. Further research is needed to validate these findings through focused investigations into apoptosis, regulation of neuronal cell death, miRNA sponges, interactions with gut microbiota, and the potential efficacy of pharmaceutical agents.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105684"},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing of the Nrf2 pathway in aging promotes a decrease in the anti-inflammatory effect of resveratrol","authors":"Filipe Nogueira Franco,&nbsp;Brenda Evangelista Peixoto,&nbsp;Glaucy Rodrigues de Araújo,&nbsp;Miriam Martins Chaves","doi":"10.1016/j.archger.2024.105694","DOIUrl":"10.1016/j.archger.2024.105694","url":null,"abstract":"<div><div>During aging, in addition to increased oxidative stress, inflammation also occurs. A chronic and low-grade inflammation - called “inflammaging” - develops, which contributes to the etiology of diseases related to aging. Resveratrol (Resv.) is a polyphenol well known for its biologically active properties, such as antioxidant and anti-inflammatory properties. This balance can be regulated by Nrf2 - a transcription factor that regulates cellular defense against oxidative agents through the expression or inhibition of certain genes. The objective was to evaluate the effect of Nrf2 on the production of cytokines in leukocytes of different ages treated with resveratrol (5µm). The subjects were divided into three groups: 20–39, 40–59 and 60–80 years old. After separation of the leukocytes, a 24-hour treatment was carried out with and without ML385 inhibitor with the treatments: Control, Resv, Peroxide and Peroxide+Resv. 150 µM peroxide was set to develop an oxidative environment. Cytokines were measured by ELISA (*<em>p</em> &lt; 0.05). In general, there was an increase in TNF and IL-6 in cells stimulated with peroxide compared to controls. A decrease in these two cytokines was also observed in cells treated with resveratrol, both at basal levels and in an oxidizing environment (with peroxide). The polyphenol was able to increase IL-10 only in the youngest age groups. The same profile was observed comparing the same groups when the Nrf2 pathway was inhibited with ML385. It is concluded that resveratrol may have a better effect on preventing oxidation and inflammation present in aging, especially through the antioxidant and anti-inflammatory Nrf2 pathway.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105694"},"PeriodicalIF":3.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the relationship between participation in salons aimed at care prevention through the promotion of social participation and the subsequent cost of care: A 3-year prospective follow-up study in JAGES","authors":"Hiroshi Hirai ,&nbsp;Masashige Saito ,&nbsp;Tokunori Takeda ,&nbsp;Katsunori Kondo","doi":"10.1016/j.archger.2024.105688","DOIUrl":"10.1016/j.archger.2024.105688","url":null,"abstract":"<div><div>Many previous studies have found that social participation improves the health and functional maintenance of older people. However, to determine whether promoting social participation can prevent functional decline in the elderly, it is necessary not only to compare the prognosis of those who participate in social activities to those who do not but also to demonstrate that the intervention was effective in promoting social participation. Although the effect of social participation in preventing caregiving has been demonstrated, the key question is whether preventing functional decline through social participation can reduce care costs. This study aims to examine the relationship between participation in salons aimed at care prevention through the promotion of social participation and the subsequent cost of care. We use the Japan Gerontological Evaluation Study (JAGES) dataset to conduct longitudinal, individuallevel analysis. We focus on all residents 65 years and older who did not have a without disability in Taketoyo town and ran three regression analyses. First, a generalized linear model (GLM) with Tweedie distribution and log-link function, as well as robust estimation of variance components was used to estimate the dependent variables. Second, we used an inverse probability weighting (IPW) model to minimize selection bias. Finally, we performed the IV analysis. In this study, the GLM with IPW and IV models revealed link between salon participants and lower caregiving costs. The link between participation and caregiving costs was confirmed in a model with reduced selection bias, rather than in a simple GLM model.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105688"},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited role of biological aging in unhealthy aging: A cross-sectional analysis of global life expectancy and disability data","authors":"Wenpeng You ,&nbsp;Luisa Garcia ,&nbsp;Kamal Hezam ,&nbsp;Hui Chen (Rita) Chang","doi":"10.1016/j.archger.2024.105691","DOIUrl":"10.1016/j.archger.2024.105691","url":null,"abstract":"<div><h3>Background</h3><div>Biological aging is known to impact quality of life, but its precise role is debated.</div></div><div><h3>Objective</h3><div>This study explores how biological aging, measured by life expectancy at birth (e0), affects unhealthy aging as indicated by years lost due to disability (YLD).</div></div><div><h3>Methods</h3><div>Data from international organizations, including e0, YLD, and confounding factors like income, obesity, and urbanization, were analyzed. Correlations were visualized with scatter plots, and associations were assessed using Pearson's and nonparametric methods. Partial, multilevel modelling and multiple regression analyses were conducted to determine e0′s impact on YLD.</div></div><div><h3>Results</h3><div>e0 strongly correlated with YLD, explaining about 50 % of its variance. After adjusting for confounders, e0’s contribution fell to 12.18 %. Multiple regression identified e0 and urbanization as significant predictors.</div></div><div><h3>Conclusions</h3><div>Biological aging influences YLD, but its effect diminishes when accounting for other factors, highlighting the need for a comprehensive approach to healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105691"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in senescence markers after a weight loss intervention in older adults with obesity","authors":"David H. Lynch ,&nbsp;Curtis L. Petersen ,&nbsp;Delisha Stewart ,&nbsp;Jamie N. Justice ,&nbsp;Dakota J Batchek ,&nbsp;Susan Sumner ,&nbsp;Susan McRitchie ,&nbsp;John A. Batsis","doi":"10.1016/j.archger.2024.105685","DOIUrl":"10.1016/j.archger.2024.105685","url":null,"abstract":"<div><h3>Background</h3><div>Understanding how weight loss interventions in older adults with obesity impact aging biology can lay the foundation for targeted, ‘geroscience-based’ interventions. This study examines the association between changes in the senescence-associated secretory phenotypes (SASP) and changes in function in response to a weight loss intervention.</div></div><div><h3>Methods</h3><div>We conducted a post-hoc biomarker analysis on adults aged ≥ 65 years with body mass index [BMI] ≥30 kg/m² enrolled in a six-month, non-randomized telemedicine-delivered weight loss intervention. We assessed 16 SASP cytokines using serum samples collected pre-and post-intervention. Clinical outcomes include anthropometric and physical function measurements. A weight loss responder was defined as a loss of ≥5 % of body weight.</div></div><div><h3>Results</h3><div>Mean age was 73.2 ± 3.9 years (73 % female), and BMI was 36.5 ± 5.2 kg/m². Responders lost 7.6 ± 2.5 %, while non-responders lost 2.0 ± 2.3 % of weight (<em>n</em> = 16 per group, <em>p</em> &lt; 0.001). We observed several significant associations between SASP cytokines and physical function and anthropometric measurement outcomes in age- and sex-adjusted linear models. These included grip strength and Interleukin-8 (IL-8) (<em>b</em> = 9.07) and Insulin-like Growth Factor 1 (IGF-1) (<em>b</em> = 2.6); gait speed and Thymus and Activation-Regulated Chemokine (TARC) (<em>b</em> = 0.46) and IL-7(<em>b</em> = 61 0.11); weight IL-6 (<em>b</em> = -6.77) and IL-15 (<em>b</em> = -2.53); BMI and IL-15 (<em>b</em> = -0.95); waist-to-hip ratio and osteopontin (<em>b</em> = -0.07) (<em>p</em> &lt; 0.05 for all).</div></div><div><h3>Conclusions</h3><div>Our pilot data demonstrated an association between changes in select SASP biomarkers and increased functional ability with intentional weight loss in older adults with obesity. However, findings must be replicated in prospective randomized trials with a control group and additional SASP biomarkers.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105685"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambivalent ageism and the pains and gains of informal caregiving for older adults: Findings from Germany","authors":"Larissa Zwar,&nbsp;Hans-Helmut König,&nbsp;Emily Delfin,&nbsp;André Hajek","doi":"10.1016/j.archger.2024.105683","DOIUrl":"10.1016/j.archger.2024.105683","url":null,"abstract":"<div><h3>Background and objectives</h3><div>We analyzed the associations between ambivalent ageism, burden and positive experiences of care among informal caregivers of older adults (aged ≥60 years), to advance understanding of its role as psychosocial risk or resilience factor for informal caregivers.</div></div><div><h3>Design and methods</h3><div>Data of 433 informal caregivers (≥18 years) of adults with care needs (≥60 years) from the Attitudes towards Informal Caregivers (ATTIC) project was used. The Ambivalent Ageism Scale, Positive Aspects of Care Scale and the Burden Scale for Family Caregivers were used. Linear regression analyses adjusted for context and personal factors were conducted, with age and gender included as moderators in additional tests.</div></div><div><h3>Results</h3><div>High ageism (total score) was significantly associated with a high level of positive aspects of care and burden. Further analyses showed a significant positive association between benevolent ageism and positive aspects of care, while stronger hostile ageism was associated with less positive aspects of care. Hostile ageism was also significantly associated with more burden, while benevolent ageism and burden were not associated. Additional analyses indicated no moderation by gender, but by age. The association between hostile ageism and burden was weaker with caregivers’ higher age.</div></div><div><h3>Discussion and implications</h3><div>While hostile ageism and worse caregiver burden were associated, positive care experiences seemed to benefit from benevolent ageism. This highlights the complex associations between ageism and caregivers’ well-being, which need to be taken into account in theory and practice focused on improving the care situation for both caregivers and care recipients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105683"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of obesity indices and their association with pain in community-dwelling older adults: Findings from the English longitudinal study of ageing","authors":"Shangmin Chen ,&nbsp;Mengzhen Min ,&nbsp;Lin Du ,&nbsp;Yongshan Gao ,&nbsp;Lei Xie ,&nbsp;Junjie Gao ,&nbsp;Liping Li ,&nbsp;Zhigang Zhong","doi":"10.1016/j.archger.2024.105690","DOIUrl":"10.1016/j.archger.2024.105690","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of pain has increased with the increase of obesity, and finding indicators to predict pain risk has become an urgent need. BMI, WC, and WHtR have the potential to be excellent predictors. However, the association of these obesity indicators with various pains remains unclear.</div></div><div><h3>Methods</h3><div>This longitudinal cohort study included 2155 pain-free participants (mean age = 68.5 years, standard deviation [SD] = 8.6) from the English Longitudinal Study of Ageing (ELSA). BMI, WC, and WHtR were measured during nurse visits at waves 0, 2, and 4. The Group-Based Trajectory Model (GBTM) was used to identify optimal trajectories for BMI, WC, and WHtR. Self-reported pain at four anatomical sites (lower back, hip, knee and total pain) was assessed at Waves 4 to 9. Cox proportional hazards models were employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between obesity indices and pain risk.</div></div><div><h3>Results</h3><div>Over a median follow-up period of 7.49 years, we observed 1,059 incident cases of all-cause pain. After adjusting for confounders, participants in the High-Stable WC group had a 30% higher risk of experiencing pain (HR: 1.30, 95 % CI: 1.05–1.60, <em>P</em> = 0.014), while those in the High-Stable WHtR group had a 29% higher risk (HR: 1.29, 95% CI: 1.06–1.56, <em>P</em> = 0.010) compared to the Low-Stable group. High-stable trajectories for BMI, WC, and WHtR were also associated with an elevated risk of back, hip, and knee pain.</div></div><div><h3>Conclusion</h3><div>This study identifies long-term obesity indices as significant predictors of pain, suggesting the importance of monitoring these measures for effective clinical risk assessments. Further research is needed to explore the underlying mechanisms of these associations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105690"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of social support and strain in predicting older adults’ sleep disturbances","authors":"Shinae Seo ,&nbsp;Meghan K. Mattos ,&nbsp;Shannon Reilly ,&nbsp;Ishan Williams ,&nbsp;Wen You","doi":"10.1016/j.archger.2024.105682","DOIUrl":"10.1016/j.archger.2024.105682","url":null,"abstract":"<div><div>Sleep disturbances impact the well-being of older adults, but there has been limited research on their longitudinal patterns and how they are affected by the quality of social relationships. This study explored longitudinal sleep disturbance patterns and examined the influence of social support and social strain on sleep disturbances in older adults using data from the Health and Retirement Study (HRS) spanning from 2010 to 2018. Group-based trajectory modeling identified distinct trajectory groups. Multinomial logistic regression and a fixed effects model investigated the relationship between sleep disturbances, social support, social strain, and sociodemographic factors. Three sleep disturbance trajectories were identified: high sleep disturbances, moderate sleep disturbances, and low sleep disturbances. Multinomial logistic regression showed that higher social support decreased the likelihood of classification in the high and moderate sleep disturbance groups. Conversely, higher social strain scores increased the likelihood of belonging to the high and moderate sleep disturbance groups. The fixed effects model confirmed the role of social support in predicting sleep disturbances over time, but social strain was not a significant predictor. These findings suggest the need for tailored interventions addressing social support to reduce sleep disturbances in this population.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105682"},"PeriodicalIF":3.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into young-onset dementia hospitalizations: An 8-year nationwide study using administrative data","authors":"Bárbara Ferraz Pinto ,&nbsp;Manuel Gonçalves-Pinho ,&nbsp;Alberto Freitas ,&nbsp;Lia Fernandes ,&nbsp;Ana Rita Ferreira","doi":"10.1016/j.archger.2024.105666","DOIUrl":"10.1016/j.archger.2024.105666","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize all Portuguese public hospitalizations of patients aged &lt; 65 years with a primary or secondary diagnosis of dementia, based on ICD-9-CM coding.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted using a nationwide database encompassing all hospitalizations occurred in Portuguese mainland public hospitals with discharge from 2008 to 2015. Hospitalizations of patients aged 35–64 years with primary or secondary diagnoses of dementia were selected based on ICD-9-CM codes 290.1X-290.4X, 291.2, 292.82, 294.1X, 294.2X, 331.0, 331.1X, 331.82, 333.4 and 046.1, excluding diagnostic codes 317-319, 330.X, 343, 758.0-758.3 and 759.3. Information on age, sex, primary diagnosis, comorbidities (secondary diagnosis), type of admission, length of stay (LoS), in-hospital mortality, suicide attempts, discharge destination, readmissions and dementia etiology was collected.</div></div><div><h3>Results</h3><div>From 7971 hospitalizations, for 5682 inpatients, the median age was 57.3 years (SD±6.5) and 61.8% were of male patients. Vascular dementia was the most prevalent etiology, followed by Alzheimer's disease. Most admissions were urgent and had a primary diagnosis of ‘Delirium, dementia and other cognitive disorders’, followed by pneumonia and alcohol-related disorders. Dementia, cerebrovascular disease and diabetes were the most common comorbidities. Overall, 55.4% of admissions were first-time admissions during the study period and the median LoS was 10.0 days (Q1;Q3: 5.0;20.0). Suicide attempts were recorded in 0.6% of the episodes. The in-hospital mortality rate was 9.2% and most patients were discharged home (80.2%).</div></div><div><h3>Conclusions</h3><div>This study describes the complexity and strain of young-onset dementia hospitalizations providing a detailed overview and recommendations for further research and tailored interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105666"},"PeriodicalIF":3.5,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}