Archives of gerontology and geriatrics最新文献

Insights into young-onset dementia hospitalizations: An 8-year nationwide study using administrative data 青年痴呆症住院情况透视：一项利用行政数据进行的为期 8 年的全国性研究。

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-11-02 DOI: 10.1016/j.archger.2024.105666

{"title":"Insights into young-onset dementia hospitalizations: An 8-year nationwide study using administrative data","authors":"","doi":"10.1016/j.archger.2024.105666","DOIUrl":"10.1016/j.archger.2024.105666","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize all Portuguese public hospitalizations of patients aged < 65 years with a primary or secondary diagnosis of dementia, based on ICD-9-CM coding.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted using a nationwide database encompassing all hospitalizations occurred in Portuguese mainland public hospitals with discharge from 2008 to 2015. Hospitalizations of patients aged 35–64 years with primary or secondary diagnoses of dementia were selected based on ICD-9-CM codes 290.1X-290.4X, 291.2, 292.82, 294.1X, 294.2X, 331.0, 331.1X, 331.82, 333.4 and 046.1, excluding diagnostic codes 317-319, 330.X, 343, 758.0-758.3 and 759.3. Information on age, sex, primary diagnosis, comorbidities (secondary diagnosis), type of admission, length of stay (LoS), in-hospital mortality, suicide attempts, discharge destination, readmissions and dementia etiology was collected.</div></div><div><h3>Results</h3><div>From 7971 hospitalizations, for 5682 inpatients, the median age was 57.3 years (SD±6.5) and 61.8% were of male patients. Vascular dementia was the most prevalent etiology, followed by Alzheimer's disease. Most admissions were urgent and had a primary diagnosis of ‘Delirium, dementia and other cognitive disorders’, followed by pneumonia and alcohol-related disorders. Dementia, cerebrovascular disease and diabetes were the most common comorbidities. Overall, 55.4% of admissions were first-time admissions during the study period and the median LoS was 10.0 days (Q1;Q3: 5.0;20.0). Suicide attempts were recorded in 0.6% of the episodes. The in-hospital mortality rate was 9.2% and most patients were discharged home (80.2%).</div></div><div><h3>Conclusions</h3><div>This study describes the complexity and strain of young-onset dementia hospitalizations providing a detailed overview and recommendations for further research and tailored interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the 25-question Geriatric Locomotive Function Scale with all-cause mortality in older adults: The Nagahama study 25 个问题的老年运动功能量表与老年人全因死亡率的关系：长滨研究

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-22 DOI: 10.1016/j.archger.2024.105670

{"title":"Association of the 25-question Geriatric Locomotive Function Scale with all-cause mortality in older adults: The Nagahama study","authors":"","doi":"10.1016/j.archger.2024.105670","DOIUrl":"10.1016/j.archger.2024.105670","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Locomotive syndrome is a condition in which a person is at risk of requiring nursing care due to musculoskeletal disorders. The 25-question Geriatric Locomotive Function Scale (GLFS-25) was developed to determine the severity of locomotive syndrome. In this study, we aimed to determine the prognostic significance of the GLFS-25 for all-cause mortality.</div></div><div><h3>Methods</h3><div>The study participants consisted of 3,447 community residents aged ≥65 years. All-cause mortality was determined using residential registry records. Skeletal muscle mass assessed via bioimpedance methods was considered in the analysis as a confounding factor.</div></div><div><h3>Results</h3><div>During a mean follow-up period of 3,236 days (30,566 person–years), 288 cases of all-cause mortality occurred. When participants were categorized by the GLFS-25 score [grade 1: <7 points (<em>n</em> = 1,948); grade 2: ≥7 to <16 points (<em>n</em> = 894); grade 3: ≥16 points (<em>n</em> = 605)], their survival probability decreased linearly with increasing grade (log-rank test <em>P</em> = 0.014). In a Cox proportional hazards model adjusted for confounding factors, including low skeletal muscle mass, GLFS-25 grade 3 was identified as an independent risk factor for all-cause mortality (hazard ratio: 1.60; <em>P</em> = 0.007) in the subpopulation aged ≥70 years but not in the overall population (<em>P</em> = 0.062). The hazard ratio for all-cause mortality with GLFS-25 grade 3 and low skeletal muscle mass combined was 2.66 (<em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>The GLFS-25 is independently associated with all-cause mortality in older adults. Using this questionnaire to assess locomotive syndrome could be useful for identifying individuals at risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Questionable prospective effect of grip strength on cognitive function: A simulated reanalysis and comment on Cui et al. (2024) 握力对认知功能的前瞻性影响值得怀疑：模拟再分析及对 Cui 等人（2024）的评论

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-22 DOI: 10.1016/j.archger.2024.105667

引用次数: 0

Cerebral small vessel disease and its relationship with all-cause mortality risk: Results from the Amsterdam Ageing cohort 脑小血管疾病及其与全因死亡风险的关系：阿姆斯特丹老龄化队列研究结果

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-22 DOI: 10.1016/j.archger.2024.105669

{"title":"Cerebral small vessel disease and its relationship with all-cause mortality risk: Results from the Amsterdam Ageing cohort","authors":"","doi":"10.1016/j.archger.2024.105669","DOIUrl":"10.1016/j.archger.2024.105669","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral Small-Vessel Disease (CSVD) is a complex condition affecting the brain's vascular network, linked to cognitive and physical decline, cerebrovascular disease, and death. This study assesses the relationship between CSVD (composite and individual features) and all-cause mortality in a large cohort of geriatric outpatients.</div></div><div><h3>Methods</h3><div>Data from 1305 geriatric outpatients (mean age 78 ± 7; 51 % female) in the Amsterdam Ageing cohort were analysed. CSVD presence was based on brain imaging (MRI or CT), defined by a Fazekas score ≥ 2, presence of ≥1 lacunes, or (in MRI) ≥ 3 microbleeds. Mortality data (February 2016 - January 2024) was sourced from the Dutch Municipality Register. The relationship between CSVD and all-cause mortality was evaluated using a Cox proportional-hazards model, adjusting for key confounders.</div></div><div><h3>Results</h3><div>At baseline, 835 (64 %) of the 1305 patients had CSVD. During a median follow-up of 3.1 years (IQR 1.6–4.6 years), all-cause mortality was 40 % (333 patients) in the CSVD group and 26 % (121 patients) in the non-CSVD group, corresponding with incidence rates of 137 and 78 per 1000 patient-years, respectively. The age- and sex-adjusted hazard ratio for mortality in the CSVD group was 1.6 (95 % CI: 1.3–2.0). This association remained significant after adjusting for cardiovascular disease and its risk factors, physical function (gait speed), and cognitive function (MMSE).</div></div><div><h3>Conclusion</h3><div>Radiographic CSVD presence is prevalent and its integration into daily care is important as it is independently linked to increased all-cause mortality in geriatric outpatients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heatwaves and its impact on the depressive symptoms among Chinese community-dwelling older adults: Examining the role of social participation 热浪及其对中国社区老年人抑郁症状的影响：探讨社会参与的作用

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-22 DOI: 10.1016/j.archger.2024.105668

{"title":"Heatwaves and its impact on the depressive symptoms among Chinese community-dwelling older adults: Examining the role of social participation","authors":"","doi":"10.1016/j.archger.2024.105668","DOIUrl":"10.1016/j.archger.2024.105668","url":null,"abstract":"<div><h3>Objectives</h3><div>Based on the Environment-Person Fit Perspective, this study explores the relationship between heatwaves and subsequent depressive symptoms among older Chinese community dwellers. Additionally, the study investigates if this association varies among older adults with different levels of social participation.</div></div><div><h3>Methods</h3><div>Heatwaves were defined as the frequency of occurrences where daily maximum temperature exceeded 35 °C for 3 consecutive days. A sample including 7124 older adults aged 55 and above was selected from the 2018 China Health and Retirement Longitudinal Study. Depressive symptoms were measured by the 10-item Centre for Epidemiological Studies Depression Scale. Social participation was measured by volunteer participation and leisure participation. Multilevel fixed effect model was employed to investigate the temporal association between heatwaves and depressive symptoms, as well as the moderating effect of social participation.</div></div><div><h3>Results</h3><div>This study found that older adults who had experienced a greater number of heatwaves presented more severe depressive symptoms (<em>b</em> = 0.66, <em>p</em> < 0.001). However, a high level of leisure participation buffered the effect of heatwaves on depressive symptoms (<em>b</em> = ̶ 0.52, <em>p</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>This study highlighted the differential impact of heatwaves on mental health outcomes among older adults depending on their levels of social participation. Our findings provide valuable insights into designing an integrative heatwave adaption scheme that simultaneously focuses on temperature adjustment and social participation enhancement.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of social activities on delayed memory in older adults: A cross-cultural study 社交活动对老年人延迟记忆的影响：跨文化研究

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-20 DOI: 10.1016/j.archger.2024.105664

引用次数: 0

Five-factor theory of aging and death due to aging 衰老和衰老导致死亡的五因素理论。

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-19 DOI: 10.1016/j.archger.2024.105665

{"title":"Five-factor theory of aging and death due to aging","authors":"","doi":"10.1016/j.archger.2024.105665","DOIUrl":"10.1016/j.archger.2024.105665","url":null,"abstract":"<div><div>This new theory of aging explains that aging and death due to aging are due to five factors, and also explains how these factors are interconnected and jointly lead to aging and death of the organism, pointing to many facts that strongly support it. The first factor is the harmful changes that occur in cellular structures. The second factor is the cessation of cell division in adult organisms, which leads to the inability to restore cellular structures. The third factor is the feature that cells do not die due to the accumulation of harmful changes that occur in the cells during the life of the organism. The fourth factor is the inability of stem cells to regenerate tissue by replacing such cells with new ones, because somatic cells do not die and there are no signals that stimulate the proliferation of stem cells and their differentiation into new ones that would replace dead cells. The fifth factor is that all cells die suddenly, due to the cessation of one of the vital functions of the organism, and not gradually during life, due to a decrease in the functionality of cells caused by the introduction of harmful changes in cellular structures, which would allow stem cells to regenerate tissues and keep the body young. Also, to show that this aging theory is valid, the theory gives its view of the evolution of five factors, which according to this theory lead to aging, which gives strong support to this theory.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of nordic walking on the cardiovascular risk factors in older adults: A systematic review and meta-analysis 溯溪行走对老年人心血管风险因素的影响：系统回顾和荟萃分析。

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-18 DOI: 10.1016/j.archger.2024.105663

{"title":"The effects of nordic walking on the cardiovascular risk factors in older adults: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.archger.2024.105663","DOIUrl":"10.1016/j.archger.2024.105663","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of Nordic walking on cardiovascular risk factors in the elderly population through a systematic review and meta-analysis of randomized controlled trials.</div></div><div><h3>Methods</h3><div>Literature searches were conducted in PubMed, Embase, Cochrane Library, and Web of Science through November 2023. Two authors independently assessed heterogeneity in subgroups, performed sensitivity and meta-regression analyses, and extracted data. Outcomes were measured using mean difference (MD) or standardized mean difference (SMD), each with a corresponding 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>A total of 22 studies comprising 1,271 subjects, with an average age of 62.21±7.76 years were included in the meta-analysis. Nordic walking significantly reduced body mass index (MD = -0.67, 95 % CI [-1.12; -0.23], <em>p</em> < 0.01), body weight (MD = -1.76, 95 % CI [-2.91; -0.62], <em>p</em> < 0.01), waist circumference (MD = -2.21, 95 % CI [-4.13; -0.29], <em>p</em> = 0.02), and body fat percentage (MD = -1.54, 95 % CI [-2.61; -0.48], <em>p</em> < 0.01). It also significantly enhanced maximal oxygen consumption (SMD = 0.60, 95 % CI [0.11; 1.10], <em>p</em> < 0.01), and reduced systolic blood pressure (MD = -2.92, 95 % CI [-5.23; -0.60], <em>p</em> < 0.01), low-density lipoprotein (SMD = -0.27, 95 % CI [-0.43; -0.12], <em>p</em> < 0.01), total cholesterol (SMD = -0.20, 95 % CI [-0.35; -0.05], <em>p</em> < 0.01), triglycerides (SMD = -0.30, 95 % CI [-0.47; -0.13], <em>p</em> < 0.01) in older adults, while also improving diastolic blood pressure in people over 65 years of age (MD =-5.26, [-8.79,-1.72], <em>p</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>Nordic walking mitigates cardiovascular risk factors in older adults and is particularly effective in improving diastolic blood pressure in individuals over 65 years of age.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between insomnia and multidimensional frailty in community-dwelling older adults: A systematic review 社区老年人失眠与多维虚弱之间的关系：系统综述。

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-18 DOI: 10.1016/j.archger.2024.105661

{"title":"The relationship between insomnia and multidimensional frailty in community-dwelling older adults: A systematic review","authors":"","doi":"10.1016/j.archger.2024.105661","DOIUrl":"10.1016/j.archger.2024.105661","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the relationship between insomnia and multidimensional frailty among community-dwelling older adults.</div></div><div><h3>Method</h3><div>We conducted a comprehensive search in the Pubmed, Web of Science, and Embase databases up to May 15, 2024. The included cross-sectional studies were using the Joanna Briggs Institute's Evidence-Based Health Care Center's checklist for analytical cross-sectional studies; the longitudinal study used the Newcastle-Ottawa Scale for risk of bias assessment.</div></div><div><h3>Results</h3><div>Out of 1571 studies, 14 were selected. The results indicate a positive relationship between insomnia and cognitive frailty, social frailty, and psychological frailty in community-dwelling older adults. However, the relationship between insomnia and total or physical frailty is unclear.</div></div><div><h3>Conclusion</h3><div>This study made an association between insomnia and cognitive frailty, social frailty, and psychological frailty in community-dwelling older adults. Due to the limited quality and quantity of the included studies, more high-quality cohort studies are required to verify the above conclusion.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetically-predicted effects of lifestyle factors on frailty: Evidence from Mendelian randomization study 基因预测的生活方式因素对虚弱的影响：孟德尔随机研究的证据。

IF 3.5 3区医学

Archives of gerontology and geriatrics Pub Date : 2024-10-17 DOI: 10.1016/j.archger.2024.105662

{"title":"Genetically-predicted effects of lifestyle factors on frailty: Evidence from Mendelian randomization study","authors":"","doi":"10.1016/j.archger.2024.105662","DOIUrl":"10.1016/j.archger.2024.105662","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the causal relationships between genetically predicted lifestyle factors and frailty using Mendelian randomization(MR).</div></div><div><h3>Methods</h3><div>We extracted summary data from genome-wide association studies conducted among individuals of European ancestry, examining lifestyle factors such as smoking, alcohol consumption, physical activity, and sedentary behaviors. The outcomes were assessed using Fried Frailty Score (FFS) and Frailty Index (FI). We conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to simultaneously assess the independent causal effects were primarily estimated using inverse variance weighted methods. Multiple sensitivity and validation analyzes were used.</div></div><div><h3>Results</h3><div>The IVW analyzes indicated that smoking increased frailty risk (FFS: β = 0.107, 95 % CI = 0.057 to 0.156, P < 0.001; FI: β = 0.899, 95 % CI = 0.016 to 0.191, <em>P</em> = 0.020.), this effect was amplified in the MVMR analysis after adjusting for alcohol consumption. Strenuous sports or other exercise(SSOE) reduced frailty risk (FFS: β = -0.473, 95 % CI = -0.646 to -0.299, P < 0.001; FI: β = -0.423, 95 % CI = -0.692 to -0.154, <em>P</em> = 0.002). Vigorous and moderate-to-vigorous physical activities were significantly related to lower FFS, although no effects were observed on FI. Increased television watching was linked to higher frailty incidence (FFS: β = 0.227, 95 % CI = 0.197 to 0.257, P < 0.001; FI: β = 0.297, 95 % CI = 0.249 to 0.346, P < 0.001), the impact remained persistent in MVMR adjusting for driving and computer use.</div></div><div><h3>Conclusion</h3><div>This study suggests that modifications in smoking, alcohol consumption, and physical activity may help prevent or manage frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0