Archives of gerontology and geriatrics最新文献

{"title":"Social context matters: Neighborhood environment as a moderator of the longitudinal relationship between edentulism and cognitive function among older adults in the United States","authors":"Ruotong Liu ,&nbsp;Xiang Qi ,&nbsp;Weiyu Mao ,&nbsp;Huabin Luo ,&nbsp;Zhijing Xu ,&nbsp;Bei Wu","doi":"10.1016/j.archger.2025.105806","DOIUrl":"10.1016/j.archger.2025.105806","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has shown poor oral health and neighborhood environment are both risk factors for cognitive decline among older adults. Little research has assessed the synergistic effects of poor oral health and neighborhood environment on cognitive health. This study examined whether neighborhood environment moderates the relationship between edentulism and cognitive function over time.</div></div><div><h3>Methods</h3><div>Using data from the Health and Retirement Study, we analyzed 9,994 adults aged 60 and older with 39,976 person-wave observations over 14 years (2006–2020). Cognitive function was measured using the modified Telephone Interview for Cognitive Status. Edentulism status was self-reported complete tooth loss. Neighborhood environment included perceived neighborhood cohesion and disorder. We used linear mixed-effect models to examine the moderation effect of neighborhood environment on the association between edentulism and cognitive function over time.</div></div><div><h3>Results</h3><div>Edentulous participants (22.4 %) showed an accelerated decline over time in cognitive function compared to dentate participants (β = -0.57, 95 % CI: -0.98, -0.16). The analysis revealed that neighborhood cohesion moderated the relationship between edentulism and cognitive function over time (β = 0.08, 95 % CI: 0.01, 0.15). Specifically, among individuals reporting higher neighborhood cohesion, the negative effect of edentulism on cognitive decline was attenuated. Neighborhood disorder had no significant associations with cognitive function.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the relationship between edentulism and cognitive function varies by levels of neighborhood cohesion. The findings highlight the significance of neighborhood context in understanding the relationship between oral health and cognitive aging and suggest interventions addressing community environment may be particularly relevant for older adults with oral health challenges.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105806"},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter 2 inhibitors in the treatment of heart failure patients: A systematic review and meta-analysis of cost-utility studies","authors":"Xinyue Zhang ,&nbsp;Yanxia Zhang ,&nbsp;Jiayu Wang ,&nbsp;Zhijia Tang","doi":"10.1016/j.archger.2025.105809","DOIUrl":"10.1016/j.archger.2025.105809","url":null,"abstract":"<div><h3>Aims</h3><div>Sodium–glucose cotransporter-2 inhibitors (SGLT-2i) have shown promise in reducing cardiovascular mortality and hospitalization due to heart failure (HF), a significant global health issue. This study aims to evaluate the incremental net benefit (INB) of SGLT-2i in HF patients through a systematic review and meta-analysis of cost-utility studies.</div></div><div><h3>Methods</h3><div>We searched five databases from their inception until Aug 30, 2024, economic evolution studies reporting cost-effectiveness and cost-utility analyses comparing SGLT-2i combined with standard triple-therapy versus standard triple-therapy alone in HF patients were selected. INB as the primary outcome was calculated in monetary units adjusted for purchasing power parity in 2022 US dollars.</div></div><div><h3>Results</h3><div>This review included 46 studies, with 41 studies (55 comparisons) pooled into meta-analysis. Adding SGLT2is was cost-effective compared to standard triple-therapy alone, from both healthcare system perspective (INB, $4042.08; 95 % CI, $1758.70-$6325.46) and payer perspective (INB, $12,972.84; 95 % CI, $4711.5-$21,234.22). However, subgroup analyses showed non-significant economic benefit in HF patients with preserved ejection fraction (HFpEF) both from the healthcare system perspective (INB, -$639.32; 95 % CI, -$1850.09-$571.44) and the payer perspective (INB, $3611.07; 95 % CI, -$208.49-$7430.64). Additionally, HF patients from low- and middle-income countries did not show significant economic benefit from the payer perspective (INB, $55,645.70; 95 % CI, -$51,000.00-$160,000.00).</div></div><div><h3>Conclusions</h3><div>The findings suggest that adding SGLT-2i is cost-effective compared to conventional standard triple-therapy alone, from both healthcare system and payer perspectives. Nevertheless, the economic benefits are limited in HFpEF and those from low- and middle-income countries. Further research is needed to explore the cost-effectiveness from a broader societal perspective.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105809"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies","authors":"Yajing Gao ,&nbsp;Yuli Huang ,&nbsp;Ran An,&nbsp;Yi Yang,&nbsp;Xinyao Chen,&nbsp;Qiaoqin Wan","doi":"10.1016/j.archger.2025.105807","DOIUrl":"10.1016/j.archger.2025.105807","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is generally an age-related condition in older people that impacts adverse health consequences in terms of quality of life, morbidity and mortality. With the increasing interest of clinical and research interest in sarcopenia internationally, the epidemiological evidence reveals sarcopenia risk begins in early adulthood, influenced by gene, lifestyle and a range of chronic conditions across life course.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to systematically summarize the risk factors for sarcopenia across the life course, and to identity the high-risk population.</div></div><div><h3>Methods</h3><div>Searches were performed in PubMed, Web of Science, Scopus, Embase, MEDLINE, and SPORTDiscus databases from inception to July 2024. Longitudinal studies assessing the risk factors for sarcopenia in community setting were included in the analysis. Fixed- and random-effect models were used to pool effect size. Based on the results of meta-analysis, we developed a risk predictive model for sarcopenia.</div></div><div><h3>Results</h3><div>Fifty-three studies were included in our systematic review. Risk factors associating with sarcopenia were grouped into eight domains: sociodemographic, anthropometric, health behaviors, health condition, biomarkers, early life factors, psychosocial and living environment factors. Fifteen risk factors derived from the twenty-three included studies were eligible for meta-analysis, and ten variables were identified as statistically significant. A risk predictive model was developed for secondary sarcopenia in community setting.</div></div><div><h3>Conclusions</h3><div>This study provides a fully understanding of sarcopenia across the life-course. Our risk predictive model could facilitate the early identification and prevention of secondary sarcopenia in community setting.</div></div><div><h3>Registration</h3><div>The systematic review and meta-analysis have been registered in PROSPERO(CRD42024536346)</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105807"},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of DNA methylation-based epigenetic age acceleration with facial expression recognition in older adults","authors":"Da-eun Lee ,&nbsp;Yinan Zheng ,&nbsp;Kyoung-Bok Min ,&nbsp;Brian Joyce ,&nbsp;Jun Wang ,&nbsp;Tao Gao ,&nbsp;Lifang Hou ,&nbsp;Sang-Won Ha ,&nbsp;Da-Eun Jeong ,&nbsp;Min-Ju Kang ,&nbsp;Jin-Young Min ,&nbsp;Kyeezu Kim","doi":"10.1016/j.archger.2025.105808","DOIUrl":"10.1016/j.archger.2025.105808","url":null,"abstract":"<div><h3>Background</h3><div>Facial expression recognition (FER) abilities play a crucial role in fostering beneficial social relationships for healthy aging, however, these abilities tend to decline as people age. We investigated the association between epigenetic age acceleration (EAA) and FER among older individuals.</div></div><div><h3>Methods</h3><div>Accuracy rates and response times for six emotions, anger, disgust, fear, happiness, sadness, and surprise, were assessed in outpatients who visited the Veterans Health Service Medical Center. We calculated six EAA measures (intrinsic EAA, extrinsic EAA, PhenoAge acceleration, GrimaAge2 acceleration, skin and blood Age Acceleration, and Dunedin Pace of Aging Calculated from the Epigenome), based on DNA methylation levels across 935,000 CpGs. We employed multiple linear regression models adjusting for demographic and socioeconomic variables.</div></div><div><h3>Results</h3><div>In men, EAA was associated with a lower accuracy rate for fear (DunedinPACE: β= -7.53, 95 % CI= -12.12, -2.95) and a higher rate for sadness (Grim2AA: β= 5.44, 95 % CI= 0.37, 10.51). In women, EAA was associated with a lower accuracy rate for anger (SBAA: β= -5.06, 95 % CI= -9.43, -0.70) and a higher rate for happiness (EEAA: β= 4.79, 95 % CI= 0.85, 8.73). In men, EAA had an association with a faster response for fear (EEAA: β= -0.24, 95 % CI= -0.44, -0.05) and in women, for all emotions except sadness.</div></div><div><h3>Conclusions</h3><div>Greater EAA was associated with higher accuracy rates in recognizing happiness among women and sadness among men. Our findings suggest that biological aging may enhance recognition of positive emotions and empathy for others' sadness, rather than simply reducing FER abilities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105808"},"PeriodicalIF":3.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction as a biomarker of frailty: The FRAMITO study protocol","authors":"Edoardo Locatelli ,&nbsp;Barbara Torsello ,&nbsp;Sofia De Marco ,&nbsp;Martina Lombardi ,&nbsp;Francesca Remelli ,&nbsp;Giulia Pampolini ,&nbsp;Elena Ferrighi ,&nbsp;Marialucia Bursi ,&nbsp;Andrea Bellotti ,&nbsp;Valentina Pasquale ,&nbsp;Giacomo Ducci ,&nbsp;Ouldouz Navaei ,&nbsp;Raffaella Candeloro ,&nbsp;Maria Cristina Ferrara ,&nbsp;Wenxiang Guo ,&nbsp;Eleonora Cucini ,&nbsp;Giuseppe Bellelli ,&nbsp;Massimiliano Castellazzi ,&nbsp;Elena Sacco ,&nbsp;Giuseppe Paglia ,&nbsp;Caterina Trevisan","doi":"10.1016/j.archger.2025.105803","DOIUrl":"10.1016/j.archger.2025.105803","url":null,"abstract":"<div><div>Frailty syndrome often coexists with multimorbidity, sharing several risk factors and outcomes. Therefore, considering multimorbidity when exploring frailty biomarkers may deepen our understanding of these conditions’ pathophysiology. In this regard, most studies focused on inflammation, but markers of mitochondrial dysfunction, such as mitochondrial DNA damage, cell respiratory impairment, and oxidative stress, are less explored. The FRAMITO project aims to evaluate mitochondrial dysfunction in frailty, with and without multimorbidity. This cross-sectional study will enroll 75 individuals aged ≥65 years from inpatient and outpatient clinics at the Geriatrics Units of the University Hospital of Ferrara (Ferrara, Italy) and Fondazione IRCCS San Gerardo dei Tintori (Monza, Italy). Participants will be categorized into three groups: 25 without frailty and multimorbidity, 25 with frailty but not multimorbidity, and 25 with frailty and multimorbidity. Blood samples will be collected to isolate Peripheral Blood Mononuclear Cells. Frailty biomarkers will be identified using untargeted metabolomics and functional studies on mitochondrial dysfunctions in PBMCs and their subpopulations, evaluating mitochondrial DNA damage, mitochondrial and glycolytic cellular bioenergetics, and intracellular reactive oxygen species. This project will advance our understanding of mitochondrial dysfunctions in frailty, particularly when combined with multimorbidity, revealing potential synergistic effects.</div></div><div><h3>Clinicaltrial.gov registration number</h3><div>NCT06433427.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105803"},"PeriodicalIF":3.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global challenge of multimorbidity in an aging world","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105804","DOIUrl":"10.1016/j.archger.2025.105804","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105804"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The connection between 91 inflammatory cytokines and frailty mediated by 1400 metabolites: An exploratory two-step Mendelian randomization analysis","authors":"Bo Wen ,&nbsp;Shizhuang Wei ,&nbsp;Daolai Huang ,&nbsp;Chao Zhang ,&nbsp;Hua Wang ,&nbsp;Sisi Liu ,&nbsp;Xianghua Wu","doi":"10.1016/j.archger.2025.105774","DOIUrl":"10.1016/j.archger.2025.105774","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, a common, multifaceted, and significant geriatric condition, involves crucial roles of inflammation and metabolic factors in its onset and progression. Nevertheless, the ambiguities and complexities in earlier observational studies make current research into their interactions somewhat insufficient. Our goals were to clarify the causal link between inflammatory cytokines and frailty and to explore the potential mediating effect of metabolites using Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Utilizing detailed summary-level data from genome-wide association studies, we conducted two-sample Mendelian randomization analyses to evaluate the potential causal connection between 91 inflammatory cytokines and the frailty index, along with the possible mediating pathways that involve 1400 metabolites. For our main analysis, we applied the inverse variance weighted method. To evaluate the potential mediating pathways of metabolites, a two-step MR analysis was utilized.</div></div><div><h3>Results</h3><div>We identified 8 inflammatory cytokines that were genetically associated with the frailty index, we subsequently identified 2 mediated relationships, with 2 metabolites acting as potential mediators between 2 inflammatory cytokines and frailty index. The 8 inflammatory cytokines were fractalkine (CX3CL1), interleukin-33 (IL-33), leukemia inhibitory factor receptor (LIF-R), monocyte chemoattractant protein-1 (CCL8), C<img>C motif chemokine 4 (CCL4), C-X-C motif chemokine 10 (CXCL10), fibroblast growth factor 5 (FGF-5), and TNF-beta (TNFB) levels.</div></div><div><h3>Conclusions</h3><div>The findings of this study demonstrate a direct connection between inflammatory cytokines and the frailty index, as well as two pathways mediated by metabolites. These biomarkers contribute valuable insights into the foundational mechanisms of frailty, presenting a novel research avenue for upcoming clinical studies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105774"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between sarcopenia and depression: A systematic review and meta-analysis","authors":"Xiangpeng Meng ,&nbsp;Ze Wang ,&nbsp;Linyu Lyu","doi":"10.1016/j.archger.2025.105787","DOIUrl":"10.1016/j.archger.2025.105787","url":null,"abstract":"<div><h3>Purpose</h3><div>Recent research has reported a potential bidirectional association between sarcopenia and depression, yet systematic evidence supporting this relationship is still lacking. This study evaluated the bidirectional association of sarcopenia with depression to provide reliable evidence for the development of specific prevention and control strategies.</div></div><div><h3>Methods</h3><div>Relevant articles were extracted from PubMed, Embase, Cochrane, and Web of Science from inception to July 4, 2024. Quality was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies, and the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for cross-sectional studies. Changes in the association between sarcopenia and depression were compared across different study designs, sources of study subjects, and sarcopenia diagnostic criteria by subgroup analyses. Meta-analysis was conducted using R 4.4.1.</div></div><div><h3>Results</h3><div>Thirty-three original studies involving 119,421 subjects were incorporated into this review. Pooled analysis revealed a significant reciprocal relationship between sarcopenia and depression in community populations. The risk of depression increased when sarcopenia was the exposure factor [OR = 2.40(95 % CI: 1.87, 3.08)]. Conversely, the risk of sarcopenia significantly increased when depression was the exposure factor [OR = 1.90(95 % CI: 1.44, 2.50)]. Additionally, there was a markedly increased risk of sarcopenia when depressive symptoms were the exposure factor [OR = 1.38(95 % CI: 1.25, 1.53)]. Similar conclusions were obtained in patients with other diseases<strong>.</strong></div></div><div><h3>Conclusions</h3><div>The significant bidirectional association between sarcopenia and depression enhances the prevention, screening, diagnosis, and treatment of depression, thereby improving quality of life and outcomes.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105787"},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Otago Exercise Program and aquatic exercise on fall risk in older adults: A systematic review","authors":"Mingyuan Dong ,&nbsp;Xi Liu ,&nbsp;Yongchul Choi ,&nbsp;Ning Li","doi":"10.1016/j.archger.2025.105799","DOIUrl":"10.1016/j.archger.2025.105799","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this systematic review was to determine the processes and forms of participation in Otago Exercise Program (OEP) and Aquatic exercise(AE) for the prevention of falls in older adults, and to compare the effectiveness of the two exercises as interventions for the prevention of falls in older adults.</div></div><div><h3>Methods</h3><div>Using electronic databases such as PubMed, Web of Science, Embase, Scopus, and Google Scholar, we searched for relevant domestic and foreign papers in the last 15 years, and evaluated the methodology and quality of the report by both AMSTAR 2 and PRISMA scales to evaluate the methodology and reporting quality.</div></div><div><h3>Results</h3><div>A total of 33 papers were included by searching various literatures related to the topic of this study and carefully reviewed by the researcher.</div></div><div><h3>Conclusion</h3><div>This systematic review confirms that OEP and AE effectively prevent falls in older adults by improving cognitive function, lower limb muscle strength, and balance. OEP significantly enhances muscle strength, while AE shows slight superiority in improving balance-related abilities like gait stability. These findings highlight the need for optimized training cycles in OEP and AE to maximize muscle adaptation. Both programs are safe and effective, with potential to reduce falls and enhance physical and cognitive functions. Tailored interventions, aligned with home health care guidelines and specific living environments, can improve quality of life. Future research should explore the optimal exercise modalities and intensities, and conduct longitudinal studies to assess long-term outcomes, particularly for older adults with specific health conditions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105799"},"PeriodicalIF":3.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary indices to measure diet quality in older cancer survivors: A scoping review on tools, their components and association with health outcomes","authors":"Andrea Boehmer ,&nbsp;Christina Syu Hong Thio ,&nbsp;Juliana Christina ,&nbsp;Michelle Miller ,&nbsp;Alex Fauer ,&nbsp;Elsa Dent ,&nbsp;Wendy Wing Tak Lam ,&nbsp;Danielle Wing Lam Ng ,&nbsp;Raymond Javan Chan ,&nbsp;Chad Yixian Han","doi":"10.1016/j.archger.2025.105797","DOIUrl":"10.1016/j.archger.2025.105797","url":null,"abstract":"<div><h3>Background</h3><div>Older cancer survivors live with more comorbidities and have a higher mortality rate compared to the general older population. A high-quality diet that adheres to evidence based dietary recommendations and guidelines may help mitigate these issues. This can be assessed using dietary quality indices (DQIs), which objectively summarize scores for selected dietary components.</div></div><div><h3>Objective</h3><div>Identify the DQIs available in the literature for older cancer survivors, and their associations with health outcomes.</div></div><div><h3>Method</h3><div>Five databases were searched to identify peer-reviewed articles in English, from inception to 12th November 2024. Two researchers independently screened 3,145 studies, extracted and qualitatively assessed data from 28 included reports from 16 studies.</div></div><div><h3>Results</h3><div>12 DQIs and 40 unique components within these indices were identified and summarised narratively. Total vegetables (<em>n</em> = 8), total fruits (<em>n</em> = 8), whole grains (<em>n</em> = 6), saturated fat (<em>n</em> = 8), and salt/sodium (<em>n</em> = 8) were the most frequently incorporated components within a DQI. All DQIs were derived from evidence-based dietary guidelines. Only three DQIs were specifically designed for oncology population. Higher diet quality was associated with higher HR-QoL in breast, prostate, and colorectal cancer survivors in all but one study. The associations between mortality and diet quality were inconsistent, depending on the type of cancer and the mortality type i.e., cancer-specific or other causes.</div></div><div><h3>Conclusions</h3><div>DQIs are associated with important health outcomes. A major knowledge gap exists in DQIs suitable for older cancer survivors. Future research should develop DQIs to better assess how high-quality diets enhance health outcomes in older cancer survivors.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105797"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}