Archives of gerontology and geriatrics最新文献

{"title":"The prognostic value of estimated glomerular filtration rate change in elderly patients undergoing valvular replacement surgery","authors":"Le Yang ,&nbsp;Zhang-jun Wu ,&nbsp;Han Weng ,&nbsp;Di Wu ,&nbsp;Jun-quan Lu ,&nbsp;Sheng-long Chen","doi":"10.1016/j.archger.2024.105719","DOIUrl":"10.1016/j.archger.2024.105719","url":null,"abstract":"<div><h3>Background</h3><div>While the estimated glomerular filtration rate (eGFR) is a common metric for assessing kidney function, its prognostic value in elderly patients undergoing valvular replacement surgery remains uncertain.</div></div><div><h3>Methods</h3><div>A total of 4531 elderly patients (aged ≥ 60 years) who underwent valvular replacement surgery at Guangdong Provincial People's Hospital in China were retrospectively included in the study, covering the period from January 2010 to April 2019. The patients were divided into four groups based on the difference between early postoperative and preoperative estimated glomerular filtration rates (eGFR): ΔeGFR ≤ 0, 0 &lt; ΔeGFR ≤ 25, 25 &lt; ΔeGFR &lt; 50, and ΔeGFR ≥ 50. The association between postoperative eGFR changes and both in-hospital and one-year mortality was examined using univariate and multivariate analyses. Kaplan-Meier curves were used to illustrate cumulative hazard rates.</div></div><div><h3>Result</h3><div>Overall, 204 patients (4.5 %) died during their hospital stay, and 344 patients (7.59 %) patients died within one year. Our analysis revealed significant differences in clinical outcomes between patients with ΔeGFR ≤ 0 and those with ΔeGFR ≥ 50. Patients with ΔeGFR ≥ 50 had higher rates of postoperative dialysis (<em>P</em> &lt; 0.001), acute heart failure (<em>P</em> = 0.037), and in-hospital mortality (<em>P</em> &lt; 0.001). Cumulative survival curves showed a markedly higher one-year mortality rate among patients with ΔeGFR ≥ 50 compared to the other three groups (<em>p</em> &lt; 0.0001). Multivariable analyses demonstrated a significant association between ΔeGFR ≥ 50 and both in-hospital mortality (OR = 2.939, <em>P</em> &lt; 0.001) and one-year all-cause mortality (HR = 2.567, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Our study identified ΔeGFR ≥ 50 as an independent risk factor for clinical events and in-hospital mortality.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105719"},"PeriodicalIF":3.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taking an age-period-cohort perspective to assess changes in the incidence of self-perceptions of aging over time","authors":"Liat Ayalon ,&nbsp;Octavio Bramajo","doi":"10.1016/j.archger.2024.105716","DOIUrl":"10.1016/j.archger.2024.105716","url":null,"abstract":"<div><div>Self-perceptions of aging (SPA) are defined as an evaluation of one's own aging. SPA can be positive (e.g., perceiving no change or improvement with age) or negative (e.g., perceived self-decline with age). We disentangle age, period, and cohort effects (e.g., attributed to a) individual differences associated with the passage of one's chronological age, b) circumstances affecting all in the same way, or c) circumstances differentially affecting groups of people born at a particular time, respectively) associated with changes in SPA over time. We relied on data from the Health and Retirement Survey collected between 2008 and 2020, consisting of 42,346 observations of individuals over the age of 50. We found a decline in the incidence of positive SPA after the age of 65 and an increase in the incidence of negative SPA, starting at 50. The effects of age on the incidence of negative and positive SPA varied somewhat across gender and ethnicity. We identified a strong linear trend suggesting a decline in negative SPA over time for Whites and Latinos. We also found a slight non-linear cohort effect in cohorts of Black men born between 1950 and 1955 and women born after 1955, with a higher relative risk of reporting negative SPA compared to other cohorts. For positive SPA, we did not identify linear or non-linear period or cohort effects. Clinically, the findings point to the susceptibility of older persons to lesser positive SPA and more negative SPA with age, thus highlighting a need for differential interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105716"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of serum uric acid-to-high density lipoprotein cholesterol ratio with age-related diseases and mortality among older population in the United States","authors":"Ziqi Chen ,&nbsp;Iokfai Cheang ,&nbsp;Qiang Qu,&nbsp;Xu Zhu,&nbsp;Yiyang Fu,&nbsp;Rongrong Gao,&nbsp;Yanli Zhou,&nbsp;Xinli Li","doi":"10.1016/j.archger.2024.105707","DOIUrl":"10.1016/j.archger.2024.105707","url":null,"abstract":"<div><h3>Background</h3><div>Older adults experience numerous physiological and socioeconomic changes that increase the risk of chronic diseases. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a potential biomarker for assessing various health conditions. This study aimed to investigate the relationship between UHR and the prevalence of age-related diseases and mortality in a nationally representative sample of older adults in the United States.</div></div><div><h3>Methods</h3><div>This retrospective cohort study utilized data from the National Health and Nutrition Examination Surveys (NHANES) 2001–2016 including 17,968 participants aged ≥ 50 years. Mortality data were obtained through the National Death Index (NDI) until December 31, 2019. UHR was calculated by dividing serum uric acid (SUA) by high-density lipoprotein cholesterol (HDL-C). Statistical analyses included Kaplan-Meier, logistic regression models, COX regression, restricted cubic spline (RCS), receiver operating characteristic (ROC), net reclassification index (NRI), integrated discrimination improvement (IDI), and mediation analyses.</div></div><div><h3>Results</h3><div>Significant positive associations were found between UHR levels and the incidence of hypertension, diabetes, chronic kidney disease (CKD), and cardiovascular disease (CVD). Higher UHR levels also correlated with increased cardiovascular and all-cause mortality. Non-linear regressions were observed between UHR and the morbidity of diabetes (<em>p</em> = 0.039), CVD (<em>p</em> = 0.036), all-cause mortality (<em>p</em> = 0.004), with a consistent inflection point at 0.1067478. Subgroup analyses indicated potential effect modifications by gender, BMI, alcohol and drug consumption. UHR outperformed SUA and HDL-C in predicting CVD, as demonstrated by ROC curves and validated by NRI and IDI scores. Mediation analysis indicated that renal impairment partially mediated the link between UHR and all-cause mortality (mediation ratio: 27.39 %).</div></div><div><h3>Conclusion</h3><div>UHR was significantly associated with the incidence of age-related diseases and mortality in adults aged over 50 years. The study provided evidence that UHR may be a more effective predictor of CVD than SUA or HDL-C alone. Our findings highlighted the potential clinical utility of UHR as a diagnostic and prognostic tool in the older population. Further research is required to generalize conclusions and understand underlying mechanisms.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105707"},"PeriodicalIF":3.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining neurocognitive assessment: The essential integration of sensory evaluation","authors":"Joana O. Pinto ,&nbsp;Artemisa R. Dores ,&nbsp;Bruno Peixoto ,&nbsp;Fernando Barbosa","doi":"10.1016/j.archger.2024.105704","DOIUrl":"10.1016/j.archger.2024.105704","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105704"},"PeriodicalIF":3.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study","authors":"Yuze Mi ,&nbsp;Shaokai Lin ,&nbsp;Ke Chen ,&nbsp;Zhendi Shu","doi":"10.1016/j.archger.2024.105706","DOIUrl":"10.1016/j.archger.2024.105706","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is one of the most common and challenging consequences of aging, which negatively affects older adults, their families, and society. Caffeine has been shown to be associated with a reduced risk of frailty by observational studies, yet its causal relationship with frailty remains to be tested using more robust methods.</div></div><div><h3>Aims</h3><div>This study aimed to explore the causal association between plasma caffeine and frailty using a two-sample Mendelian Randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Single nucleotide polymorphisms related to plasma caffeine concentrations were selected as instrumental variables. Data on the Frailty Index (FI) were sourced from the UK Biobank and TwinGen meta-analysis (<em>n</em> = 175,226), while data on the Fried Frailty Score (FFS) were obtained from the UK Biobank (<em>n</em> = 386,565). The causal association between plasma caffeine levels and frailty was tested using five MR methods, with the inverse-variance weighted method as the primary approach.</div></div><div><h3>Results</h3><div>Our results consistently showed significantly negative associations between genetically predicted plasma caffeine with FI (<em>β</em> = -0.050, 95 % CI:0.077 to -0.023, <em>P</em> &lt; 0.001) and FFS (<em>β</em> = -0.049, 95 % CI:0.064 to -0.034, <em>P</em> &lt; 0.001). These results remained robust in further sensitivity analyses using a leave-one-out approach.</div></div><div><h3>Conclusion</h3><div>Our findings confirm a causal relationship between plasma caffeine and frailty and suggest that increasing plasma caffeine levels may help prevent and reduce the risk of frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105706"},"PeriodicalIF":3.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separating neurocognitive mechanisms of maintenance and compensation to support financial ability in middle-aged and older adults: The role of language and the inferior frontal gyrus","authors":"Macarena Suárez-Pellicioni ,&nbsp;Ian M. McDonough","doi":"10.1016/j.archger.2024.105705","DOIUrl":"10.1016/j.archger.2024.105705","url":null,"abstract":"<div><div>This study investigated the role of brain regions involved in arithmetic processing in explaining individual differences in financial ability in 67 50–74-year-old cognitively normal adults. Structural integrity and resting-state functional connectivity measures were collected in the MRI scanner. Outside the scanner, participants performed financial ability and other cognitive tasks, and answered questionnaires to determine dementia risk, and financial risk and protective factors. Regions of interest involved in arithmetic processing were defined, focusing on language- and quantity-processing areas in temporo-frontal and parieto-frontal cortices, respectively. Our results showed that structural integrity and functional connectivity in brain regions associated with arithmetic retrieval were positively associated with financial ability, with language skill mediating left IFG structural integrity and financial ability. Connectivity patterns suggested that reliance on quantity mechanisms (i.e. calculation) was associated with poorer financial ability. Analyses revealed that reliance on these brain mechanisms did not depend on participants’ age or risk of dementia and that protective factors such as household income or financial literacy supported the maintenance of connectivity related to financial abilities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105705"},"PeriodicalIF":3.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The polygenic hazard score mediates the association between plasma neurofilament light chain and brain morphometry in dementia spectrum","authors":"Hamide Nasiri ,&nbsp;Mohammad Hossein Azaraein ,&nbsp;Shayan Shakeri ,&nbsp;Mohammad Sadeghi ,&nbsp;Ahmadreza Sohrabi-Ashlaghi ,&nbsp;Soorin Berenjian ,&nbsp;Shirin Karimian ,&nbsp;Zahra Hoseinzadeh ,&nbsp;Masoumeh Saberi Rounkian ,&nbsp;Mahsa Mayeli ,&nbsp;for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.archger.2024.105703","DOIUrl":"10.1016/j.archger.2024.105703","url":null,"abstract":"<div><h3>Introduction</h3><div>Blood-based biomarkers such as plasma neurofilament light chain (pNfL) are crucial biomarkers for Alzheimer's disease (AD). Additionally, neuroimaging techniques such as tensor-based morphometry (TBM), which identify structural changes in the brain, can provide valuable insights into AD pathophysiology. However, the role of genetics in linking the blood based biomarkers and imaging findings has not been well understood. Therefore, we aimed to investigate whether the polygenic hazard score (PHS), affects the association between neurofibrillary tangles and neuritis plaques and brain imaging findings.</div></div><div><h3>Methods</h3><div>Using the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, we enrolled all participants for whom a complete dataset of pNfL, PHS, and TBM was available. Using Python, we analyzed the associations between pNfL levels and the TBM data of 567 participants incluidng 152 cognitively normal individuals, 309 participants with mild cognitive impairment (MCI), and 106 patients with AD. We used a mediation analysis to identify the effect of PHS in how pNfL is associated with TBM measures.</div></div><div><h3>Results</h3><div>We found a negative correlation between the accelerated TBM measure and NfL levels in both the MCI and AD groups. The pNfL concentration predicted both accelerated statistical and anatomical TMB measures in patients with MCI. Furthermore, PHS mediatedthe association between statistical TBM measures and NfL levels in AD patients, to the extent that the significant association between NfL and TBM measures disappeared after accounting for PHS.</div></div><div><h3>Conclusion</h3><div>We showed that although pNfL can predict the cognitiee decline and imaging findings in AD, this effect is mediated by the PHS. Therefore, PHS should be considered when investigating AD biomarkers and their corresponding imaging findings.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105703"},"PeriodicalIF":3.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined healthy lifestyle behaviors and all-cause mortality risk in middle-aged and older US adults: A longitudinal cohort study","authors":"Luyao Qiao,&nbsp;Yan Wang,&nbsp;Yi Deng,&nbsp;Jiaxing Peng,&nbsp;Yanping Li,&nbsp;Min Li,&nbsp;Zhenyu Tang","doi":"10.1016/j.archger.2024.105702","DOIUrl":"10.1016/j.archger.2024.105702","url":null,"abstract":"<div><h3>Background</h3><div>While various lifestyle behaviors separately or partly have been shown to be associated with health outcomes, including a multitude of diseases and death, none of the earlier research has comprehensively investigated the combined impact of modified lifestyle behaviors. This longitudinal study investigated the association between a composite of healthy lifestyle behaviors and all-cause mortality in middle-aged and older Americans.</div></div><div><h3>Methods</h3><div>We utilized data from the National Health and Nutrition Examination Survey from 2007 to 2018, as well as relevant mortality data, applying the Healthy Lifestyle Score<span><span>¹</span></span> (HLS) index to assess healthy lifestyle behaviors, defined by no smoking, moderate alcohol, appropriate sleep, a balanced diet, adequate physical activity, and limited sedentary time. Weighted multivariate Cox proportional hazards analyses were applied to investigate the associations between these lifestyle practices and overall mortality, followed by stratified analyses to explore potential effect modifications by subgroups.</div></div><div><h3>Results</h3><div>This study included 5448 participants, categorized into unfavorable (28%), intermediate (56%), and favorable (16%) HLS groups. During a median 103-month follow-up, 388 participants died. Cox regression revealed that individuals with favorable lifestyles had a reduced likelihood of death than those with unfavorable lifestyles (HR = 0.49, 95% CI: 0.34–0.70). There was a linear negative relationship established between HLS and the likelihood of all-cause death (<em>p</em> for non-linearity = 0.0512).</div></div><div><h3>Conclusion</h3><div>Adherence to a composite of healthy habits is linearly and substantially related to decreasing the likelihood of all-cause mortality among the elderly in the U.S., highlighting the substantial benefits of maintaining these behaviors for longevity and health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105702"},"PeriodicalIF":3.5,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do obstructive and restrictive pulmonary disorders increase the incidence risk of dynapenia in adults aged 50 and older?","authors":"Thales Batista de Souza ,&nbsp;Roberta de Oliveira Máximo ,&nbsp;Isabella Letícia de Pádua Cruz e Souza ,&nbsp;Thaís Barros Pereira da Silva ,&nbsp;Mariane Marques Luiz ,&nbsp;Sara Souza Lima ,&nbsp;Natália Cochar-Soares ,&nbsp;Leticia Coelho Silveira ,&nbsp;Valdete Regina Guandalini ,&nbsp;Patrícia Silva Tofani ,&nbsp;Andrew Steptoe ,&nbsp;Cesar de Oliveira ,&nbsp;Tiago da Silva Alexandre","doi":"10.1016/j.archger.2024.105701","DOIUrl":"10.1016/j.archger.2024.105701","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate whether obstructive or restrictive lung disorders are associated with the incidence of dynapenia in individuals aged 50 and over.</div></div><div><h3>Methods</h3><div>Longitudinal study involving 4,975 participants from the <em>English Longitudinal Study of Aging (ELSA)</em> aged 50 or older, without dynapenia at baseline, followed for eight years. Lung function was assessed by spirometry (predicted percentage) and participants were classified as no pulmonary disorder (FEV₁ ≥ 80 %, FVC ≥ 80 % and FEV₁/FVC ≥ 70 %); with obstructive pulmonary disorder (FEV₁ &lt; 80 %, FEV₁/FVC &lt; 70 % and normal FVC or &lt; 80 %); or with restrictive pulmonary disorder (FVC &lt; 80 %, FEV₁/FVC &gt; 70 % and normal or &lt; 80 % FEV₁). The incidence of dynapenia was defined by handgrip strength &lt; 26 kg for men and &lt; 16 kg for women. Association between obstructive or restrictive pulmonary disorders and the incidence of dynapenia were investigated using Poisson regression models adjusted for sociodemographic, behavioural, and clinical characteristics.</div></div><div><h3>Results</h3><div>The incidence density of dynapenia was 14.2/1000 person-years (95 %CI 12.6–15.9) in those without pulmonary disorders, 25.1/1000 person-years (95 % CI 21.2–29.7) in those with restrictive pulmonary disorders and 36.6/1000 person-years (95 % CI 23.8–56.1) in those with obstructive pulmonary disorders. Having an obstructive pulmonary disorder increased the risk of developing dynapenia by 62 % (95 % CI 1.09–2.41), while having a restrictive pulmonary disorder increased the risk by 37 % (95 % CI 1.13–1.64).</div></div><div><h3>Conclusion</h3><div>Obstructive and restrictive pulmonary disorders are risk factors for a higher incidence of dynapenia in individuals aged 50 years or older.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105701"},"PeriodicalIF":3.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of non-rheumatic valvular heart disease in older adults (60–89 years old), 1990–2019: Systematic analysis of the Global Burden of Disease Study 2019","authors":"Zhili Dou ,&nbsp;Xuan Lai ,&nbsp;Xiaotian Zhong ,&nbsp;Suiyuan Hu ,&nbsp;Yanyan Shi ,&nbsp;Jinzhu Jia","doi":"10.1016/j.archger.2024.105700","DOIUrl":"10.1016/j.archger.2024.105700","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the global burden and risk factors of non-rheumatic valvular heart disease (NRVHD) in older adults is important for effective disease control. We wanted to analyze the prevalence, incidence, disability-adjusted life years (DALY) rate, mortality rate, and risk factors of NRVHD in older adults aged 60–89 years.</div></div><div><h3>Methods</h3><div>Global Burden of Disease Study (GBD) 2019 was used as the data source. Age standardized incidence rate, prevalence, DALY rate, and mortality rate of NRVHD among older adults aged 60–89 years from 1990 to 2019. We analyzed different age groups, genders, regions, sociodemographic index (SDI) across 204 countries/territories. Proportional DALY and mortality attributable to risk factors were calculated.</div></div><div><h3>Results</h3><div>Globally, age-standardized DALY rate (per 100,000 population) for NRVHD in older adults decreased significantly from 44.46 (95 % confidence interval 39.95 to 49.18) in 1990 to 35.94 (32.32 to 40.19) in 2019 with an average annual percent change (AAPC) of -0.19 % (-0.24 % to -0.14 %), and the mortality rate also decreased significantly from 2.48 (2.21 to 2.64) to 2.25 (1.89 to 2.47) with an AAPC of -0.09 % (-0.16 % to -0.03 %,). However, the age-standardized incidence rate (per 100,000 population) increased from 18.37 (17.41 to 19.35) in 1990 to 19.77(18.62 to 20.95) in 2019 with an AAPC of 0.08 % (0.05 % to 0.10 %), and the age-standardized prevalence rate significantly increased from 391.40 (372.71 to 411.20) to 399.50 (378.31 to 420.75) with an AAPC of 0.02 % (0.00 % to 0.05 %). At the regional level, the greatest burden of NRVHD was seen in parts of high-income North America. At the national level, the highest age standardized incidence rate, age standardized DALY rate, and age standardized mortality rate in 2019 were all from Niger, Philippines and Belarus, making it the region with the greatest burden of NRVHD. The age standardized incidence and DALY rate were higher in women 20.83 (19.68 to 22.02) than in men 18.64 (17.39 to 19.88) globally, while the mortality rate was similar in different genders. The differences between men and women in incidence, DALY and mortality were mainly found in age groups of 80–84 and 85–89 years. A significant negative association was found between estimated annual percentage change (EAPCs) and age standardized rate (<em>q</em>=-0.19, <em>p</em> = 0.00). A significant positive relation was detected between EAPCs and human development index (<em>q</em> = 0.17, <em>p</em> = 0.02). The main attributable risk factor for DALY was high body mass index in all regions by SDI.</div></div><div><h3>Conclusion</h3><div>There is a substantial global burden of NRVHD in older adults in 2019, which is varied by age, gender, SDI and region. NRVHD in older people should be paid attention to. Risk factors described here should provide more evidence and clues for disease prevention in the future.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"130 ","pages":"Article 105700"},"PeriodicalIF":3.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}