Archives of gerontology and geriatrics最新文献

{"title":"Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults","authors":"Brendan L. McNeish ,&nbsp;Iva Miljkovic ,&nbsp;Matthew A. Allison ,&nbsp;Timothy Hughes ,&nbsp;Ilya Nasrallah ,&nbsp;Eric Terkpertey ,&nbsp;Caterina Rosano","doi":"10.1016/j.archger.2025.105823","DOIUrl":"10.1016/j.archger.2025.105823","url":null,"abstract":"<div><h3>Background</h3><div>Prior research linking myosteatosis with cognition in older adults has been conducted in relatively homogenous populations with narrow age ranges. We evaluated if abdominal myosteatosis was associated with processing speed in a multiethnic cohort of middle aged and older adults.</div></div><div><h3>Methods</h3><div>The sample included 1,268 adults (46–86 years-old, mean 63±9 years, 53 % female, 41 % White, 20 % Black, 14 % Chinese, and 25 % Hispanic), a subset from the Multi-Ethnic Study of Atherosclerosis. Bivariate analyses examined the relationships between abdominal computed tomography-derived muscle density (measure of myosteatosis) at clinical exam 3, Digit Symbol Coding (DSC) performance at clinical exam 5, and cytokine levels from clinical exam 1. Multivariable models were adjusted for demographics, education, general cognition, and further adjusted for other known predictors of dementia: <em>APOE</em>-4, physical activity, diabetes, cholesterol, smoking, and blood pressure. We assessed whether central adiposity, general adiposity, and cytokines modified this association. We tested interactions by ethnicity, sex, and age.</div></div><div><h3>Results</h3><div>Rectus abdominis myosteatosis was significantly associated with worse DSC (B=-0.247, 95 % CI: 0.098,0.396, p = 0.001) independent of demographics, education, general cognition, and dementia risk factors. Adjustment for central adiposity, and cytokines did not attenuate the associations and interactions by ethnicity, sex, and age were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Rectus abdominis myosteatosis is associated with worse processing speed in this middle and older aged multiethnic population of men and women, independent of known predictors of cognition. Longitudinal studies should assess the interplay of myosteatosis with other markers of adiposity, inflammation, and circulating mediators and their impact on processing speed.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105823"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The temporal trend in frailty prevalence from 2011 to 2020 and disparities by equity factors among middle-aged and older people in China: A population-based study","authors":"Dongfeng Tang ,&nbsp;Katie J Sheehan ,&nbsp;Aicha Goubar ,&nbsp;Julie Whitney ,&nbsp;Matthew DL O'Connell","doi":"10.1016/j.archger.2025.105822","DOIUrl":"10.1016/j.archger.2025.105822","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a challenging issue in China, however the prevalence of frailty across different population groups and whether this is changing over time remain unclear.</div></div><div><h3>Methods</h3><div>Unstandardized and age-and sex-standardized prevalence of frailty (95 % confidence interval (95 % CI)) (Frailty Index) in the overall sample and for subgroups defined by equity factors (PROGRESS-Plus framework) from 2011 to 2020 were estimated using analyses of cross-sectional surveys in adults aged 45 and older participating in 5 waves (<em>N</em> = 16,784 to 18,904 across waves) of the China Health and Retirement Longitudinal Studies (CHARLS). Poisson regression was used to estimate prevalence ratios (PRs) of frailty by equity factors.</div></div><div><h3>Results</h3><div>Unstandardized prevalence of frailty increased from 13.6 % (13.0 %-14.1 %) in 2011 to 18.7 % (18.1 %-19.3 %) in 2020.The standardized prevalence increased from 13.5 % (13.0 %-14.0 %) in 2011 to 16.3 % (15.8 %-16.9 %) in 2020. Frailty was consistently more prevalent at advanced ages, in rural areas, among females, as well as those less educated, without social engagement, and non-drinkers. Based on the Poisson regression model, non-north region, being female and older, lower education, having no social engagement, smoking and non-drinking, and higher household capital consumption were associated with higher prevalence.</div></div><div><h3>Conclusions</h3><div>The prevalence of frailty among the middle-aged and older population in China has increased. There will be an associated health and social care cost. Interventions targeted at older adults, those in rural areas, women, as well as those less educated, having no social engagement, and non-drinkers to mitigate the negative effects of frailty may be warranted.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105822"},"PeriodicalIF":3.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social context matters: Neighborhood environment as a moderator of the longitudinal relationship between edentulism and cognitive function among older adults in the United States","authors":"Ruotong Liu ,&nbsp;Xiang Qi ,&nbsp;Weiyu Mao ,&nbsp;Huabin Luo ,&nbsp;Zhijing Xu ,&nbsp;Bei Wu","doi":"10.1016/j.archger.2025.105806","DOIUrl":"10.1016/j.archger.2025.105806","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has shown poor oral health and neighborhood environment are both risk factors for cognitive decline among older adults. Little research has assessed the synergistic effects of poor oral health and neighborhood environment on cognitive health. This study examined whether neighborhood environment moderates the relationship between edentulism and cognitive function over time.</div></div><div><h3>Methods</h3><div>Using data from the Health and Retirement Study, we analyzed 9,994 adults aged 60 and older with 39,976 person-wave observations over 14 years (2006–2020). Cognitive function was measured using the modified Telephone Interview for Cognitive Status. Edentulism status was self-reported complete tooth loss. Neighborhood environment included perceived neighborhood cohesion and disorder. We used linear mixed-effect models to examine the moderation effect of neighborhood environment on the association between edentulism and cognitive function over time.</div></div><div><h3>Results</h3><div>Edentulous participants (22.4 %) showed an accelerated decline over time in cognitive function compared to dentate participants (β = -0.57, 95 % CI: -0.98, -0.16). The analysis revealed that neighborhood cohesion moderated the relationship between edentulism and cognitive function over time (β = 0.08, 95 % CI: 0.01, 0.15). Specifically, among individuals reporting higher neighborhood cohesion, the negative effect of edentulism on cognitive decline was attenuated. Neighborhood disorder had no significant associations with cognitive function.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the relationship between edentulism and cognitive function varies by levels of neighborhood cohesion. The findings highlight the significance of neighborhood context in understanding the relationship between oral health and cognitive aging and suggest interventions addressing community environment may be particularly relevant for older adults with oral health challenges.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105806"},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication challenges and response strategies of late-deafened older adults","authors":"Gianna Kohl,&nbsp;Erin M. Heniff,&nbsp;Maya E. Dye,&nbsp;Wendy A. Rogers","doi":"10.1016/j.archger.2025.105821","DOIUrl":"10.1016/j.archger.2025.105821","url":null,"abstract":"<div><h3>Background</h3><div>A growing number of adults are aging with hearing impairments. Late-deafened individuals, who experience severe to profound hearing loss after acquiring spoken language, often face unique communication challenges in everyday activities. Despite these difficulties, little is known about the specific activities and contexts where they occur.</div></div><div><h3>Objectives</h3><div>To identify activities that present communication challenges for late-deafened older adults and to explore the response strategies they adopt to manage these challenges.</div></div><div><h3>Methods</h3><div>The Aging Concerns, Challenges, and Everyday Solution Strategies (ACCESS) study uses a mixed-methods approach to explore the daily challenges faced by individuals aging with long-term disabilities. Sixty participants (66.7 % female; M age = 69.3, <em>SD</em> = 6.0) with severe to profound bilateral hearing loss for at least ten years completed questionnaires and structured interviews. Qualitative data were analyzed using content analysis.</div></div><div><h3>Results</h3><div>The content analysis revealed communication challenges with healthcare appointments, entertainment events, interactions with unfamiliar people, and group activities. Specific difficulties included general hearing impairments, challenging listening environments, limitations of assistive technologies, reliance on auditory stimuli, and insufficient social support. To manage these challenges, participants employed various strategies, including the use of assistive technologies, personal amplification devices, communication repair techniques, adaptive communication methods, and disclosing their hearing status.</div></div><div><h3>Conclusions</h3><div>The findings highlight the diverse range of communication challenges faced by late-deafened older adults. The identified strategies illustrated their resilience and adaptability but also underscored areas for improvement. Enhanced assistive technologies, better environmental accommodations, and supportive policies are essential to address these challenges effectively.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105821"},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness analysis of tube feeding among older adults with advanced dementia in Japan: A net benefit regression approach","authors":"Ning Liu ,&nbsp;Akira Babazono ,&nbsp;Kenshi Hayashida ,&nbsp;Aziz Jamal ,&nbsp;Reiko Ishihara ,&nbsp;Reiko Yamao ,&nbsp;Shinichiro Yoshida ,&nbsp;Shinya Matsuda ,&nbsp;Yunfei Li","doi":"10.1016/j.archger.2025.105812","DOIUrl":"10.1016/j.archger.2025.105812","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to assess the cost-effectiveness of percutaneous endoscopic gastrostomy (PEG) and nasogastric tube (NGT) in older adults with advanced dementia, compared with non-artificial nutrition.</div></div><div><h3>Methods</h3><div>Retrospective cohort study. Medical claims data and long-term care claims data from Fukuoka Prefecture, Japan, were used. We identified 3,882 older adults (≥75 years) with advanced dementia who were hospitalized between April 2016 and March 2019 due to dysphagia, malnutrition, or aspiration pneumonia. Using propensity score matching, we matched 192 patients in the PEG group with 192 in the non-artificial nutrition group, and 490 patients in the NGT group with 490 in the non-artificial nutrition group. We examined the survival years and total costs of each patient from the date of admission to March 31, 2020, and thereby estimated the cost-effectiveness of PEG and NGT, respectively, versus non-artificial nutrition. The net benefit regression model was employed to estimate the incremental net benefits (INB) with varying values of willingness-to-pay (WTP) for PEG and NGT. Furthermore, cost-effectiveness acceptability curve was used to present the probability of the cost-effectiveness of each intervention.</div></div><div><h3>Results</h3><div>As WTP increased from JPY 7,747,909 (equivalent to US$51,546) to JPY 28,163,651 (equivalent to US$187,371), the probability of PEG being cost-effective increased from 50 % to nearly100 %. The NGT group had negative INB estimates.</div></div><div><h3>Conclusions</h3><div>Both PEG and NGT are less likely to provide economic values for patients with advanced dementia. However, this conclusion should be further refined through detailed cost-effectiveness analysis from multiple perspectives.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105812"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the triglyceride-glucose index on non-alcoholic fatty liver disease: Causal evidence from longitudinal cohort studies","authors":"Tengrui Cao ,&nbsp;Xuetong Ni ,&nbsp;Aheyeerke Halengbieke ,&nbsp;Jianmin Tang ,&nbsp;Yumei Han ,&nbsp;Feng Sun ,&nbsp;Bo Gao ,&nbsp;Deqiang Zheng ,&nbsp;Yuxiang Yan ,&nbsp;Xinghua Yang","doi":"10.1016/j.archger.2025.105813","DOIUrl":"10.1016/j.archger.2025.105813","url":null,"abstract":"<div><h3>Background</h3><div>Insulin resistance (IR) is strongly related to non-alcoholic fatty liver disease (NAFLD). Triglyceride-glucose (TyG) index serves as a novel substitute indicator for IR. However, research on the effect of TyG index on NAFLD remains sparse. This study aims to investigate the causal association between TyG index and incident NAFLD.</div></div><div><h3>Methods</h3><div>The primary cohort consisted of 27,052 participants from the Beijing Health Management Cohort, while the external validation cohort included 75,023 participants from the Taiwan MJ Cohort. Entropy balancing for continuous treatments (EBCT) combined with logistic regression and targeted maximum likelihood estimation (TMLE) were used to evaluate the causal association between the TyG index and incident NAFLD.</div></div><div><h3>Results</h3><div>During a median follow-up of 2.49 years in the primary cohort, 6,168 participants (median age: 36.0 years) developed incident NAFLD. EBCT combined with logistic regression revealed the odds ratio (95 % CI) of NAFLD risk was 1.742 (1.478–2.054) for each 1-unit increase in the baseline TyG index. In the TMLE model, the risk ratio (95 % CI) for NAFLD was 1.540 (1.406–1.687) in the Q4 (quartile 4) group compared with the Q1 group. These findings were consistent with those from the external validation cohort, reinforcing the robustness of the causal relationship between the TyG index and NAFLD incidence.</div></div><div><h3>Conclusions</h3><div>The advanced double-robust estimation method suggests that a higher baseline TyG index may be causally associated with an increased NAFLD risk, providing more reliable evidence for its role as a simple biomarker and demonstrating the utility of double-robust estimation causal inference models in epidemiology.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105813"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter 2 inhibitors in the treatment of heart failure patients: A systematic review and meta-analysis of cost-utility studies","authors":"Xinyue Zhang ,&nbsp;Yanxia Zhang ,&nbsp;Jiayu Wang ,&nbsp;Zhijia Tang","doi":"10.1016/j.archger.2025.105809","DOIUrl":"10.1016/j.archger.2025.105809","url":null,"abstract":"<div><h3>Aims</h3><div>Sodium–glucose cotransporter-2 inhibitors (SGLT-2i) have shown promise in reducing cardiovascular mortality and hospitalization due to heart failure (HF), a significant global health issue. This study aims to evaluate the incremental net benefit (INB) of SGLT-2i in HF patients through a systematic review and meta-analysis of cost-utility studies.</div></div><div><h3>Methods</h3><div>We searched five databases from their inception until Aug 30, 2024, economic evolution studies reporting cost-effectiveness and cost-utility analyses comparing SGLT-2i combined with standard triple-therapy versus standard triple-therapy alone in HF patients were selected. INB as the primary outcome was calculated in monetary units adjusted for purchasing power parity in 2022 US dollars.</div></div><div><h3>Results</h3><div>This review included 46 studies, with 41 studies (55 comparisons) pooled into meta-analysis. Adding SGLT2is was cost-effective compared to standard triple-therapy alone, from both healthcare system perspective (INB, $4042.08; 95 % CI, $1758.70-$6325.46) and payer perspective (INB, $12,972.84; 95 % CI, $4711.5-$21,234.22). However, subgroup analyses showed non-significant economic benefit in HF patients with preserved ejection fraction (HFpEF) both from the healthcare system perspective (INB, -$639.32; 95 % CI, -$1850.09-$571.44) and the payer perspective (INB, $3611.07; 95 % CI, -$208.49-$7430.64). Additionally, HF patients from low- and middle-income countries did not show significant economic benefit from the payer perspective (INB, $55,645.70; 95 % CI, -$51,000.00-$160,000.00).</div></div><div><h3>Conclusions</h3><div>The findings suggest that adding SGLT-2i is cost-effective compared to conventional standard triple-therapy alone, from both healthcare system and payer perspectives. Nevertheless, the economic benefits are limited in HFpEF and those from low- and middle-income countries. Further research is needed to explore the cost-effectiveness from a broader societal perspective.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105809"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies","authors":"Yajing Gao ,&nbsp;Yuli Huang ,&nbsp;Ran An,&nbsp;Yi Yang,&nbsp;Xinyao Chen,&nbsp;Qiaoqin Wan","doi":"10.1016/j.archger.2025.105807","DOIUrl":"10.1016/j.archger.2025.105807","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is generally an age-related condition in older people that impacts adverse health consequences in terms of quality of life, morbidity and mortality. With the increasing interest of clinical and research interest in sarcopenia internationally, the epidemiological evidence reveals sarcopenia risk begins in early adulthood, influenced by gene, lifestyle and a range of chronic conditions across life course.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to systematically summarize the risk factors for sarcopenia across the life course, and to identity the high-risk population.</div></div><div><h3>Methods</h3><div>Searches were performed in PubMed, Web of Science, Scopus, Embase, MEDLINE, and SPORTDiscus databases from inception to July 2024. Longitudinal studies assessing the risk factors for sarcopenia in community setting were included in the analysis. Fixed- and random-effect models were used to pool effect size. Based on the results of meta-analysis, we developed a risk predictive model for sarcopenia.</div></div><div><h3>Results</h3><div>Fifty-three studies were included in our systematic review. Risk factors associating with sarcopenia were grouped into eight domains: sociodemographic, anthropometric, health behaviors, health condition, biomarkers, early life factors, psychosocial and living environment factors. Fifteen risk factors derived from the twenty-three included studies were eligible for meta-analysis, and ten variables were identified as statistically significant. A risk predictive model was developed for secondary sarcopenia in community setting.</div></div><div><h3>Conclusions</h3><div>This study provides a fully understanding of sarcopenia across the life-course. Our risk predictive model could facilitate the early identification and prevention of secondary sarcopenia in community setting.</div></div><div><h3>Registration</h3><div>The systematic review and meta-analysis have been registered in PROSPERO(CRD42024536346)</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105807"},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of DNA methylation-based epigenetic age acceleration with facial expression recognition in older adults","authors":"Da-eun Lee ,&nbsp;Yinan Zheng ,&nbsp;Kyoung-Bok Min ,&nbsp;Brian Joyce ,&nbsp;Jun Wang ,&nbsp;Tao Gao ,&nbsp;Lifang Hou ,&nbsp;Sang-Won Ha ,&nbsp;Da-Eun Jeong ,&nbsp;Min-Ju Kang ,&nbsp;Jin-Young Min ,&nbsp;Kyeezu Kim","doi":"10.1016/j.archger.2025.105808","DOIUrl":"10.1016/j.archger.2025.105808","url":null,"abstract":"<div><h3>Background</h3><div>Facial expression recognition (FER) abilities play a crucial role in fostering beneficial social relationships for healthy aging, however, these abilities tend to decline as people age. We investigated the association between epigenetic age acceleration (EAA) and FER among older individuals.</div></div><div><h3>Methods</h3><div>Accuracy rates and response times for six emotions, anger, disgust, fear, happiness, sadness, and surprise, were assessed in outpatients who visited the Veterans Health Service Medical Center. We calculated six EAA measures (intrinsic EAA, extrinsic EAA, PhenoAge acceleration, GrimaAge2 acceleration, skin and blood Age Acceleration, and Dunedin Pace of Aging Calculated from the Epigenome), based on DNA methylation levels across 935,000 CpGs. We employed multiple linear regression models adjusting for demographic and socioeconomic variables.</div></div><div><h3>Results</h3><div>In men, EAA was associated with a lower accuracy rate for fear (DunedinPACE: β= -7.53, 95 % CI= -12.12, -2.95) and a higher rate for sadness (Grim2AA: β= 5.44, 95 % CI= 0.37, 10.51). In women, EAA was associated with a lower accuracy rate for anger (SBAA: β= -5.06, 95 % CI= -9.43, -0.70) and a higher rate for happiness (EEAA: β= 4.79, 95 % CI= 0.85, 8.73). In men, EAA had an association with a faster response for fear (EEAA: β= -0.24, 95 % CI= -0.44, -0.05) and in women, for all emotions except sadness.</div></div><div><h3>Conclusions</h3><div>Greater EAA was associated with higher accuracy rates in recognizing happiness among women and sadness among men. Our findings suggest that biological aging may enhance recognition of positive emotions and empathy for others' sadness, rather than simply reducing FER abilities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105808"},"PeriodicalIF":3.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction as a biomarker of frailty: The FRAMITO study protocol","authors":"Edoardo Locatelli ,&nbsp;Barbara Torsello ,&nbsp;Sofia De Marco ,&nbsp;Martina Lombardi ,&nbsp;Francesca Remelli ,&nbsp;Giulia Pampolini ,&nbsp;Elena Ferrighi ,&nbsp;Marialucia Bursi ,&nbsp;Andrea Bellotti ,&nbsp;Valentina Pasquale ,&nbsp;Giacomo Ducci ,&nbsp;Ouldouz Navaei ,&nbsp;Raffaella Candeloro ,&nbsp;Maria Cristina Ferrara ,&nbsp;Wenxiang Guo ,&nbsp;Eleonora Cucini ,&nbsp;Giuseppe Bellelli ,&nbsp;Massimiliano Castellazzi ,&nbsp;Elena Sacco ,&nbsp;Giuseppe Paglia ,&nbsp;Caterina Trevisan","doi":"10.1016/j.archger.2025.105803","DOIUrl":"10.1016/j.archger.2025.105803","url":null,"abstract":"<div><div>Frailty syndrome often coexists with multimorbidity, sharing several risk factors and outcomes. Therefore, considering multimorbidity when exploring frailty biomarkers may deepen our understanding of these conditions’ pathophysiology. In this regard, most studies focused on inflammation, but markers of mitochondrial dysfunction, such as mitochondrial DNA damage, cell respiratory impairment, and oxidative stress, are less explored. The FRAMITO project aims to evaluate mitochondrial dysfunction in frailty, with and without multimorbidity. This cross-sectional study will enroll 75 individuals aged ≥65 years from inpatient and outpatient clinics at the Geriatrics Units of the University Hospital of Ferrara (Ferrara, Italy) and Fondazione IRCCS San Gerardo dei Tintori (Monza, Italy). Participants will be categorized into three groups: 25 without frailty and multimorbidity, 25 with frailty but not multimorbidity, and 25 with frailty and multimorbidity. Blood samples will be collected to isolate Peripheral Blood Mononuclear Cells. Frailty biomarkers will be identified using untargeted metabolomics and functional studies on mitochondrial dysfunctions in PBMCs and their subpopulations, evaluating mitochondrial DNA damage, mitochondrial and glycolytic cellular bioenergetics, and intracellular reactive oxygen species. This project will advance our understanding of mitochondrial dysfunctions in frailty, particularly when combined with multimorbidity, revealing potential synergistic effects.</div></div><div><h3>Clinicaltrial.gov registration number</h3><div>NCT06433427.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105803"},"PeriodicalIF":3.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}