Archives of gerontology and geriatrics最新文献

{"title":"Limited role of biological aging in unhealthy aging: A cross-sectional analysis of global life expectancy and disability data","authors":"Wenpeng You ,&nbsp;Luisa Garcia ,&nbsp;Kamal Hezam ,&nbsp;Hui Chen (Rita) Chang","doi":"10.1016/j.archger.2024.105691","DOIUrl":"10.1016/j.archger.2024.105691","url":null,"abstract":"<div><h3>Background</h3><div>Biological aging is known to impact quality of life, but its precise role is debated.</div></div><div><h3>Objective</h3><div>This study explores how biological aging, measured by life expectancy at birth (e0), affects unhealthy aging as indicated by years lost due to disability (YLD).</div></div><div><h3>Methods</h3><div>Data from international organizations, including e0, YLD, and confounding factors like income, obesity, and urbanization, were analyzed. Correlations were visualized with scatter plots, and associations were assessed using Pearson's and nonparametric methods. Partial, multilevel modelling and multiple regression analyses were conducted to determine e0′s impact on YLD.</div></div><div><h3>Results</h3><div>e0 strongly correlated with YLD, explaining about 50 % of its variance. After adjusting for confounders, e0’s contribution fell to 12.18 %. Multiple regression identified e0 and urbanization as significant predictors.</div></div><div><h3>Conclusions</h3><div>Biological aging influences YLD, but its effect diminishes when accounting for other factors, highlighting the need for a comprehensive approach to healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105691"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in senescence markers after a weight loss intervention in older adults with obesity","authors":"David H. Lynch ,&nbsp;Curtis L. Petersen ,&nbsp;Delisha Stewart ,&nbsp;Jamie N. Justice ,&nbsp;Dakota J Batchek ,&nbsp;Susan Sumner ,&nbsp;Susan McRitchie ,&nbsp;John A. Batsis","doi":"10.1016/j.archger.2024.105685","DOIUrl":"10.1016/j.archger.2024.105685","url":null,"abstract":"<div><h3>Background</h3><div>Understanding how weight loss interventions in older adults with obesity impact aging biology can lay the foundation for targeted, ‘geroscience-based’ interventions. This study examines the association between changes in the senescence-associated secretory phenotypes (SASP) and changes in function in response to a weight loss intervention.</div></div><div><h3>Methods</h3><div>We conducted a post-hoc biomarker analysis on adults aged ≥ 65 years with body mass index [BMI] ≥30 kg/m² enrolled in a six-month, non-randomized telemedicine-delivered weight loss intervention. We assessed 16 SASP cytokines using serum samples collected pre-and post-intervention. Clinical outcomes include anthropometric and physical function measurements. A weight loss responder was defined as a loss of ≥5 % of body weight.</div></div><div><h3>Results</h3><div>Mean age was 73.2 ± 3.9 years (73 % female), and BMI was 36.5 ± 5.2 kg/m². Responders lost 7.6 ± 2.5 %, while non-responders lost 2.0 ± 2.3 % of weight (<em>n</em> = 16 per group, <em>p</em> &lt; 0.001). We observed several significant associations between SASP cytokines and physical function and anthropometric measurement outcomes in age- and sex-adjusted linear models. These included grip strength and Interleukin-8 (IL-8) (<em>b</em> = 9.07) and Insulin-like Growth Factor 1 (IGF-1) (<em>b</em> = 2.6); gait speed and Thymus and Activation-Regulated Chemokine (TARC) (<em>b</em> = 0.46) and IL-7(<em>b</em> = 61 0.11); weight IL-6 (<em>b</em> = -6.77) and IL-15 (<em>b</em> = -2.53); BMI and IL-15 (<em>b</em> = -0.95); waist-to-hip ratio and osteopontin (<em>b</em> = -0.07) (<em>p</em> &lt; 0.05 for all).</div></div><div><h3>Conclusions</h3><div>Our pilot data demonstrated an association between changes in select SASP biomarkers and increased functional ability with intentional weight loss in older adults with obesity. However, findings must be replicated in prospective randomized trials with a control group and additional SASP biomarkers.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105685"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambivalent ageism and the pains and gains of informal caregiving for older adults: Findings from Germany","authors":"Larissa Zwar,&nbsp;Hans-Helmut König,&nbsp;Emily Delfin,&nbsp;André Hajek","doi":"10.1016/j.archger.2024.105683","DOIUrl":"10.1016/j.archger.2024.105683","url":null,"abstract":"<div><h3>Background and objectives</h3><div>We analyzed the associations between ambivalent ageism, burden and positive experiences of care among informal caregivers of older adults (aged ≥60 years), to advance understanding of its role as psychosocial risk or resilience factor for informal caregivers.</div></div><div><h3>Design and methods</h3><div>Data of 433 informal caregivers (≥18 years) of adults with care needs (≥60 years) from the Attitudes towards Informal Caregivers (ATTIC) project was used. The Ambivalent Ageism Scale, Positive Aspects of Care Scale and the Burden Scale for Family Caregivers were used. Linear regression analyses adjusted for context and personal factors were conducted, with age and gender included as moderators in additional tests.</div></div><div><h3>Results</h3><div>High ageism (total score) was significantly associated with a high level of positive aspects of care and burden. Further analyses showed a significant positive association between benevolent ageism and positive aspects of care, while stronger hostile ageism was associated with less positive aspects of care. Hostile ageism was also significantly associated with more burden, while benevolent ageism and burden were not associated. Additional analyses indicated no moderation by gender, but by age. The association between hostile ageism and burden was weaker with caregivers’ higher age.</div></div><div><h3>Discussion and implications</h3><div>While hostile ageism and worse caregiver burden were associated, positive care experiences seemed to benefit from benevolent ageism. This highlights the complex associations between ageism and caregivers’ well-being, which need to be taken into account in theory and practice focused on improving the care situation for both caregivers and care recipients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105683"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of obesity indices and their association with pain in community-dwelling older adults: Findings from the English longitudinal study of ageing","authors":"Shangmin Chen ,&nbsp;Mengzhen Min ,&nbsp;Lin Du ,&nbsp;Yongshan Gao ,&nbsp;Lei Xie ,&nbsp;Junjie Gao ,&nbsp;Liping Li ,&nbsp;Zhigang Zhong","doi":"10.1016/j.archger.2024.105690","DOIUrl":"10.1016/j.archger.2024.105690","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of pain has increased with the increase of obesity, and finding indicators to predict pain risk has become an urgent need. BMI, WC, and WHtR have the potential to be excellent predictors. However, the association of these obesity indicators with various pains remains unclear.</div></div><div><h3>Methods</h3><div>This longitudinal cohort study included 2155 pain-free participants (mean age = 68.5 years, standard deviation [SD] = 8.6) from the English Longitudinal Study of Ageing (ELSA). BMI, WC, and WHtR were measured during nurse visits at waves 0, 2, and 4. The Group-Based Trajectory Model (GBTM) was used to identify optimal trajectories for BMI, WC, and WHtR. Self-reported pain at four anatomical sites (lower back, hip, knee and total pain) was assessed at Waves 4 to 9. Cox proportional hazards models were employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between obesity indices and pain risk.</div></div><div><h3>Results</h3><div>Over a median follow-up period of 7.49 years, we observed 1,059 incident cases of all-cause pain. After adjusting for confounders, participants in the High-Stable WC group had a 30% higher risk of experiencing pain (HR: 1.30, 95 % CI: 1.05–1.60, <em>P</em> = 0.014), while those in the High-Stable WHtR group had a 29% higher risk (HR: 1.29, 95% CI: 1.06–1.56, <em>P</em> = 0.010) compared to the Low-Stable group. High-stable trajectories for BMI, WC, and WHtR were also associated with an elevated risk of back, hip, and knee pain.</div></div><div><h3>Conclusion</h3><div>This study identifies long-term obesity indices as significant predictors of pain, suggesting the importance of monitoring these measures for effective clinical risk assessments. Further research is needed to explore the underlying mechanisms of these associations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105690"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging with rejuvenation or morbidity and disability expansion?","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2024.105686","DOIUrl":"10.1016/j.archger.2024.105686","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105686"},"PeriodicalIF":3.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of social support and strain in predicting older adults’ sleep disturbances","authors":"Shinae Seo ,&nbsp;Meghan K. Mattos ,&nbsp;Shannon Reilly ,&nbsp;Ishan Williams ,&nbsp;Wen You","doi":"10.1016/j.archger.2024.105682","DOIUrl":"10.1016/j.archger.2024.105682","url":null,"abstract":"<div><div>Sleep disturbances impact the well-being of older adults, but there has been limited research on their longitudinal patterns and how they are affected by the quality of social relationships. This study explored longitudinal sleep disturbance patterns and examined the influence of social support and social strain on sleep disturbances in older adults using data from the Health and Retirement Study (HRS) spanning from 2010 to 2018. Group-based trajectory modeling identified distinct trajectory groups. Multinomial logistic regression and a fixed effects model investigated the relationship between sleep disturbances, social support, social strain, and sociodemographic factors. Three sleep disturbance trajectories were identified: high sleep disturbances, moderate sleep disturbances, and low sleep disturbances. Multinomial logistic regression showed that higher social support decreased the likelihood of classification in the high and moderate sleep disturbance groups. Conversely, higher social strain scores increased the likelihood of belonging to the high and moderate sleep disturbance groups. The fixed effects model confirmed the role of social support in predicting sleep disturbances over time, but social strain was not a significant predictor. These findings suggest the need for tailored interventions addressing social support to reduce sleep disturbances in this population.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105682"},"PeriodicalIF":3.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into young-onset dementia hospitalizations: An 8-year nationwide study using administrative data","authors":"Bárbara Ferraz Pinto ,&nbsp;Manuel Gonçalves-Pinho ,&nbsp;Alberto Freitas ,&nbsp;Lia Fernandes ,&nbsp;Ana Rita Ferreira","doi":"10.1016/j.archger.2024.105666","DOIUrl":"10.1016/j.archger.2024.105666","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize all Portuguese public hospitalizations of patients aged &lt; 65 years with a primary or secondary diagnosis of dementia, based on ICD-9-CM coding.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted using a nationwide database encompassing all hospitalizations occurred in Portuguese mainland public hospitals with discharge from 2008 to 2015. Hospitalizations of patients aged 35–64 years with primary or secondary diagnoses of dementia were selected based on ICD-9-CM codes 290.1X-290.4X, 291.2, 292.82, 294.1X, 294.2X, 331.0, 331.1X, 331.82, 333.4 and 046.1, excluding diagnostic codes 317-319, 330.X, 343, 758.0-758.3 and 759.3. Information on age, sex, primary diagnosis, comorbidities (secondary diagnosis), type of admission, length of stay (LoS), in-hospital mortality, suicide attempts, discharge destination, readmissions and dementia etiology was collected.</div></div><div><h3>Results</h3><div>From 7971 hospitalizations, for 5682 inpatients, the median age was 57.3 years (SD±6.5) and 61.8% were of male patients. Vascular dementia was the most prevalent etiology, followed by Alzheimer's disease. Most admissions were urgent and had a primary diagnosis of ‘Delirium, dementia and other cognitive disorders’, followed by pneumonia and alcohol-related disorders. Dementia, cerebrovascular disease and diabetes were the most common comorbidities. Overall, 55.4% of admissions were first-time admissions during the study period and the median LoS was 10.0 days (Q1;Q3: 5.0;20.0). Suicide attempts were recorded in 0.6% of the episodes. The in-hospital mortality rate was 9.2% and most patients were discharged home (80.2%).</div></div><div><h3>Conclusions</h3><div>This study describes the complexity and strain of young-onset dementia hospitalizations providing a detailed overview and recommendations for further research and tailored interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105666"},"PeriodicalIF":3.5,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the 25-question Geriatric Locomotive Function Scale with all-cause mortality in older adults: The Nagahama study","authors":"Yasuharu Tabara ,&nbsp;Tome Ikezoe ,&nbsp;Kazuya Setoh ,&nbsp;Takahisa Kawaguchi ,&nbsp;Fumihiko Matsuda","doi":"10.1016/j.archger.2024.105670","DOIUrl":"10.1016/j.archger.2024.105670","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Locomotive syndrome is a condition in which a person is at risk of requiring nursing care due to musculoskeletal disorders. The 25-question Geriatric Locomotive Function Scale (GLFS-25) was developed to determine the severity of locomotive syndrome. In this study, we aimed to determine the prognostic significance of the GLFS-25 for all-cause mortality.</div></div><div><h3>Methods</h3><div>The study participants consisted of 3,447 community residents aged ≥65 years. All-cause mortality was determined using residential registry records. Skeletal muscle mass assessed via bioimpedance methods was considered in the analysis as a confounding factor.</div></div><div><h3>Results</h3><div>During a mean follow-up period of 3,236 days (30,566 person–years), 288 cases of all-cause mortality occurred. When participants were categorized by the GLFS-25 score [grade 1: &lt;7 points (<em>n</em> = 1,948); grade 2: ≥7 to &lt;16 points (<em>n</em> = 894); grade 3: ≥16 points (<em>n</em> = 605)], their survival probability decreased linearly with increasing grade (log-rank test <em>P</em> = 0.014). In a Cox proportional hazards model adjusted for confounding factors, including low skeletal muscle mass, GLFS-25 grade 3 was identified as an independent risk factor for all-cause mortality (hazard ratio: 1.60; <em>P</em> = 0.007) in the subpopulation aged ≥70 years but not in the overall population (<em>P</em> = 0.062). The hazard ratio for all-cause mortality with GLFS-25 grade 3 and low skeletal muscle mass combined was 2.66 (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The GLFS-25 is independently associated with all-cause mortality in older adults. Using this questionnaire to assess locomotive syndrome could be useful for identifying individuals at risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105670"},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questionable prospective effect of grip strength on cognitive function: A simulated reanalysis and comment on Cui et al. (2024)","authors":"Kimmo Sorjonen,&nbsp;Bo Melin","doi":"10.1016/j.archger.2024.105667","DOIUrl":"10.1016/j.archger.2024.105667","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105667"},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral small vessel disease and its relationship with all-cause mortality risk: Results from the Amsterdam Ageing cohort","authors":"Julia H.I. Wiersinga ,&nbsp;Hadil M. Diab ,&nbsp;Mike J.L. Peters ,&nbsp;Marijke C. Trappenburg ,&nbsp;Hanneke F.M. Rhodius-Meester ,&nbsp;Majon Muller","doi":"10.1016/j.archger.2024.105669","DOIUrl":"10.1016/j.archger.2024.105669","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral Small-Vessel Disease (CSVD) is a complex condition affecting the brain's vascular network, linked to cognitive and physical decline, cerebrovascular disease, and death. This study assesses the relationship between CSVD (composite and individual features) and all-cause mortality in a large cohort of geriatric outpatients.</div></div><div><h3>Methods</h3><div>Data from 1305 geriatric outpatients (mean age 78 ± 7; 51 % female) in the Amsterdam Ageing cohort were analysed. CSVD presence was based on brain imaging (MRI or CT), defined by a Fazekas score ≥ 2, presence of ≥1 lacunes, or (in MRI) ≥ 3 microbleeds. Mortality data (February 2016 - January 2024) was sourced from the Dutch Municipality Register. The relationship between CSVD and all-cause mortality was evaluated using a Cox proportional-hazards model, adjusting for key confounders.</div></div><div><h3>Results</h3><div>At baseline, 835 (64 %) of the 1305 patients had CSVD. During a median follow-up of 3.1 years (IQR 1.6–4.6 years), all-cause mortality was 40 % (333 patients) in the CSVD group and 26 % (121 patients) in the non-CSVD group, corresponding with incidence rates of 137 and 78 per 1000 patient-years, respectively. The age- and sex-adjusted hazard ratio for mortality in the CSVD group was 1.6 (95 % CI: 1.3–2.0). This association remained significant after adjusting for cardiovascular disease and its risk factors, physical function (gait speed), and cognitive function (MMSE).</div></div><div><h3>Conclusion</h3><div>Radiographic CSVD presence is prevalent and its integration into daily care is important as it is independently linked to increased all-cause mortality in geriatric outpatients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105669"},"PeriodicalIF":3.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}