Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project

IF 3.5 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Ted K.S. Ng , Todd Beck , Xiaoran Liu , Pankaja Desai , Thomas Holland , Klodian Dhana , Kristin Krueger , Robert S. Wilson , Denis A. Evans , Kumar B. Rajan
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引用次数: 0

Abstract

Background

There have been contradictory findings on the associations between lipids and cognitive decline (CD), which may be attributed to the heterogeneity in the APOE4 carrier status, given APOE's lipid transportation roles. However, extant studies rarely examined the modifying effects of APOE4 carrier status on the associations between lipids and CD.

Methods

We analyzed the Chicago Health and Aging Project, a 20-year cohort study comprising older adults with lipid panel assayed, i.e., total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), and longitudinal cognitive tests. We ran adjusted linear mixed-effects models, regressing cognitive test composite on each of the four lipids independently, first with the total sample and subsequently using interaction and stratified subgroup analyses, examining the modifying effects of APOE4 carrier status on the associations.

Results

3,496 biracial community-dwelling older adults were recruited from the South side of Chicago (58% African American & 64% women; mean follow-up = 4.6 years). In the total sample, there was a borderline association between TG and CD, estimate (SD, p-value) = 0.0001 (0.0000,0.0565). No associations were detected with other lipids. In the interaction and subgroup analyses, only in ε4 carriers that higher TC levels were significantly associated with accelerated CD, -0.020 (0.009,0.035), whereas higher TG levels were significantly associated with decelerated CD, 0.001 (0.001,0.045). No modifying effects of ε4 carrier status were detected with other lipids.

Discussion

Specific lipids, i.e., TC and TG, were associated with CD only in the ε4 carriers, highlighting the potential importance of measuring APOE4 status to better inform risk prediction and treatment.
来自芝加哥健康与老龄化项目的研究结果:在双种族社区居住的老年人中,脂质面板与apoe4携带者状态改变的认知能力下降之间的纵向关联
关于脂质与认知能力下降(CD)之间的关系,一直有相互矛盾的发现,这可能归因于APOE4载体状态的异质性,考虑到APOE的脂质运输作用。然而,现有的研究很少考察APOE4携带者状态对脂质与cd之间关系的调节作用。方法我们分析了芝加哥健康与衰老项目,这是一项为期20年的队列研究,包括老年人的脂质面板分析,即总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL),以及纵向认知测试。我们运行了调整后的线性混合效应模型,对四种脂类中的每一种独立的认知测试组合进行回归,首先使用总样本,然后使用相互作用和分层亚组分析,检查APOE4携带者身份对这些关联的修改作用。结果从芝加哥南部招募了3,496名居住在社区的混血儿老年人(58%是非裔美国人;64%的女性;平均随访4.6年)。在总样本中,TG和CD之间存在临界相关性,估计(SD, p值)= 0.0001(0.0000,0.0565)。与其他脂质无关联。在相互作用和亚组分析中,只有在ε4携带者中,较高的TC水平与加速CD显著相关,为-0.020(0.009,0.035),而较高的TG水平与减速CD显著相关,为0.001(0.001,0.045)。其他脂类对ε4载流子状态无修饰作用。特定脂质,即TC和TG,仅在ε4携带者中与CD相关,这突出了测量APOE4状态对更好地预测风险和治疗的潜在重要性。
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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