Archives of gerontology and geriatrics最新文献

{"title":"Ageism and the feminization of old age: A Systematic review","authors":"Juan Robles Costa ,&nbsp;Angélica Quintero-Flórez ,&nbsp;Emilio García-Cabrera ,&nbsp;Julia Romero-Barranca ,&nbsp;Ángel Vilches-Arenas","doi":"10.1016/j.archger.2025.106084","DOIUrl":"10.1016/j.archger.2025.106084","url":null,"abstract":"<div><h3>Background</h3><div>Increases in life expectancy and declining birth rates have intensified the demographic weight of older adults, particularly women. This population frequently faces intersecting age and gender-based discrimination, resulting in greater health burdens and lower quality of life compared to men.</div></div><div><h3>Objective</h3><div>To examine gender-based disparities affecting older adults, particularly older women, intending to uncover underlying mechanisms and contribute to the formulation of more equitable, gender-responsive, and age-sensitive public health policies.</div></div><div><h3>Study design</h3><div>This systematic review followed PRISMA guidelines and was registered in PROSPERO (CRD420251104219).</div></div><div><h3>Methods</h3><div>Six databases were searched (2014–2024) for studies in English or Spanish on gender- and age-based health inequalities in older adults. Eligible systematic reviews, observational, and experimental studies were quality-assessed (PRISMA, STROBE, CONSORT), and findings were synthesized qualitatively.</div></div><div><h3>Results</h3><div>Fourteen studies met the inclusion criteria. Across contexts, older women consistently exhibited higher prevalence of disability, frailty, depression, and poorer self-rated health, frequently linked to lower educational attainment and income. In contrast, older men showed lower prevalence of these conditions but faced higher mortality risks from frailty and suicide. Men also tended to report better subjective quality of life.</div></div><div><h3>Conclusions</h3><div>While women live longer, they often experience greater illness and functional limitations. Socioeconomic disadvantages explain part of these gaps, but a considerable proportion remains unexplained. These findings highlight the urgent need for gender- and age-sensitive public health strategies to reduce inequities in later life.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106084"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Home-Based interventions for older adults with frailty or pre-frailty: a systematic review and meta-analysis","authors":"Gengxin Yao ,&nbsp;Fei Li ,&nbsp;Xuehan Ma ,&nbsp;Xinyu Wan ,&nbsp;Yali Yang ,&nbsp;Yiran Xu ,&nbsp;Lishuang Zheng ,&nbsp;Guichen Li ,&nbsp;Li Chen","doi":"10.1016/j.archger.2025.106083","DOIUrl":"10.1016/j.archger.2025.106083","url":null,"abstract":"<div><h3>Aim</h3><div>To systematically summarise the characteristics and effectiveness of home-based interventions on health outcomes in older adults with frailty or pre-frailty.</div></div><div><h3>Design</h3><div>Systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>Seven databases were searched from their inception through 31st October 2024. Two reviewers independently performed study screening, selection, data extraction, and quality appraisal. Pooled effects were quantified using standardised mean differences (SMDs) with 95 % confidence intervals (CIs). Risk of bias and evidence certainty were assessed using RoB2 and GRADE, respectively.</div></div><div><h3>Results</h3><div>Twenty-four studies (20 RCTs; <em>n</em> = 3, 826 participants) were included. The meta-analysis demonstrated that home-based interventions significantly reduced frailty phenotype scores (SMD = -0.27, 95 % CI:0.39 to -0.15) and depressive symptoms (SMD = -0.11, 95 % CI:0.20 to -0.01), alongside marked increases in grip strength (MD = 0.84, 95 % CI: 0.26 to 1.42) and mental health-related quality of life (SMD = 0.17, 95 % CI: 0.04 to 0.30). Subgroup analyses indicated that significant improvements in physical function were observed only in supervised subgroup. No significant changes were observed for overall quality of life, or physical health-related quality of life.</div></div><div><h3>Conclusions</h3><div>Home-based interventions are a valuable strategy for improving frailty, grip strength, and mental health outcomes in older adults with frailty or pre-frailty. Improvements in physical function appear to depend on home-based interventions delivered under professional supervision, while the unsupervised mode may pose the risk of potential iatrogenic harm and therefore necessitates caution alongside safety monitoring.</div></div><div><h3>Reporting Method</h3><div>This review followed PRISMA guidelines (PROSPERO: CRD42024604527).</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106083"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between changes in social isolation status and frailty among older adults","authors":"Cho Rong Kim ,&nbsp;Jisu Ko ,&nbsp;Min Jin Ha ,&nbsp;Kui Son Choi ,&nbsp;Eun-Cheol Park","doi":"10.1016/j.archger.2025.106080","DOIUrl":"10.1016/j.archger.2025.106080","url":null,"abstract":"<div><h3>Introduction</h3><div>Considering social isolation in approaches to frailty is important for the early detection of health problems in older adults and the development of appropriate intervention strategies. This study aims to investigate the relationship between changes in social isolation and frailty using the data the Korea Longitudinal Study of Aging (2006–2022).</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted with 17,932 adults aged ≥65 years. Frailty was assessed using the frailty index, changes in social isolation were categorized into four groups. Associations between changes in social isolation and frailty were examined using generalized estimating equations with logistic regression to account for repeated measures and within-subject correlations.</div></div><div><h3>Results</h3><div>Compared to participants who remained non-isolated, those whose social isolation status changed from a non-isolated to isolated state had 3.47 times higher odds of frailty (95 % confidence interval [CI]: 3.03–3.96), and those in a consistently isolated state had 3.18 times higher odds (95 % CI: 2.80–3.62). Analysis by frailty type indicated that the transition from non-isolated to isolated status exhibited a stronger association with psychological frailty (odds ratio [OR] 4.38, 95 % CI 4.36–4.39) than physical frailty, and the highest increase was observed in the likelihood of exhibiting both physical and psychological frailty (OR 6.81, 95 % CI 6.77–6.84).</div></div><div><h3>Conclusions</h3><div>The transition to an isolated state was associated with frailty among older adults. These findings emphasize the need for early identification and active interventions to address social isolation to prevent frailty among older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106080"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association between sleep disorders and delirium: A bidirectional mendelian randomization analysis for clinical practice","authors":"Wenxiu Niu ,&nbsp;Jingjing Zhang ,&nbsp;Xuhong Lan ,&nbsp;Yuhan Sha ,&nbsp;Xiaomeng Han ,&nbsp;Jijun Qiao ,&nbsp;Fei Zheng ,&nbsp;Lu Liu ,&nbsp;Fangli Ma ,&nbsp;Li Yao ,&nbsp;Zhigang Zhang","doi":"10.1016/j.archger.2025.106046","DOIUrl":"10.1016/j.archger.2025.106046","url":null,"abstract":"<div><h3>Background</h3><div>Numerous studies have identified a correlation between sleep disorders and delirium; however, the causal relationship remains ambiguous. This bidirectional two-sample Mendelian randomization (MR) study, combined with colocalization and enrichment analyses, aims to investigate the potential causal relationship between sleep-associated phenotypes and delirium.</div></div><div><h3>Methods</h3><div>We performed a two-sample bidirectional Mendelian randomization analysis using 10 gene variants associated with sleep phenotypes to investigate the causal relationship between sleep disorders and delirium. Five methods for MR Analysis. Moreover, sensitivity analyses were conducted to assess the robustness of our findings. Enrichment and colocalization analyses were conducted to uncover the genetic mechanisms linking sleep phenotypes and delirium.</div></div><div><h3>Results</h3><div>The IVW method showed that insomnia positively correlates with delirium (OR = 2.523, 95 % CI: 1.048–6.079, <em>P</em> = 0.039). Morning person is causally negatively associated with delirium (OR = 0.869, 95 % CI: 0.774–0.977, <em>P</em> = 0.018). Conversely, delirium is negatively associated with daytime napping (OR = 0.987, 95 % CI: 0.984–0.990, <em>P</em> &lt; 0.001), insomnia (OR = 0.985, 95 % CI: 0.981–0.989, <em>P</em> &lt; 0.001), snoring (OR = 0.991, 95 % CI: 0.985–0.997, <em>P</em> = 0.002), and single item chronotype (beta = -0.161, 95 % CI:0.241–0.081, <em>P</em> = 0.002). Insomnia-related genes are enriched in neuro-metabolic and epigenetic pathways, while Morning person is linked to circadian rhythm regulation. A morning person shares genetic signals with delirium at the rs2398144 locus on chromosome 16 (PPH4 &gt; 0.5).</div></div><div><h3>Conclusions</h3><div>Our findings provide evidence for a potential causal relationship between sleep disorders and delirium.These findings may support better prevention and management of delirium in older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106046"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engagement in cognitive activities and risk of loneliness: A longitudinal study among Japanese older adults","authors":"Fumio Sakimoto ,&nbsp;Takehiko Doi ,&nbsp;Sho Nakakubo ,&nbsp;Soichiro Matsuda ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2025.106061","DOIUrl":"10.1016/j.archger.2025.106061","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness is a growing public health concern due to its association with adverse health outcomes in older adults. Research on the relationship between participation in cognitive activities and the alleviation of loneliness remains limited. This study examined longitudinal associations between engagement in cognitive activities and the onset of loneliness among community-dwelling older adults in Japan.</div></div><div><h3>Methods</h3><div>The prospective cohort initially included 5563 older adults. After excluding participants with baseline loneliness or missing data, 2317 participants (mean age 73.5 ± 5.4 years; 58.1 % women) were analyzed and followed for 36.7 ± 2.3 months. Loneliness was assessed using the UCLA Loneliness Scale. Six cognitive activities were evaluated: reading, keeping a diary, solving crossword puzzles, playing board games, participating in group discussions, and playing musical instruments. Logistic regression, adjusted for demographic, lifestyle, health, and cognitive covariates, examined associations of individual activities and total activity frequency with the onset of loneliness.</div></div><div><h3>Results</h3><div>During follow-up, 574 participants (24.8 %) developed loneliness. Reading (OR = 0.61, 95 % CI = 0.41–0.91, <em>p</em> = .01) and participating in group discussions (OR = 0.63, 95 % CI = 0.51–0.77, <em>p</em> &lt; .001) were significantly associated with a reduced risk of loneliness. Frequent engagement in other cognitive activities was not associated with lower loneliness.</div></div><div><h3>Conclusions and implications</h3><div>Engagement in specific cognitive activities was associated with lower odds of loneliness. These findings suggest that it may be important to consider not only the frequency of cognitive activities but also their specific characteristics and qualities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106061"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145384571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in the associations of community gathering place participation with healthy ageing","authors":"Kazushige Ide ,&nbsp;Kenjiro Kawaguchi ,&nbsp;Ryota Watanabe ,&nbsp;Aki Shibata ,&nbsp;Kiyomi Matsumura ,&nbsp;Taishi Tsuji ,&nbsp;Katsunori Kondo ,&nbsp;Atsushi Nakagomi","doi":"10.1016/j.archger.2025.106060","DOIUrl":"10.1016/j.archger.2025.106060","url":null,"abstract":"<div><h3>Background</h3><div>Extending healthy life expectancy is a critical policy priority in aging societies worldwide. In Japan, community gathering places (CGPs) for older adults, which are resident-led group activities conducted in accessible local spaces. While prior studies have suggested benefits of CGPs participation, most evidence is limited to single municipalities. The potential heterogeneity in benefits across sociodemographic subgroups remains unclear.</div></div><div><h3>Methods</h3><div>We analyzed data from 55,982 community-dwelling older adults aged 65 years or older across 21 municipalities participating in the Japan Gerontological Evaluation Study. We linked pre-baseline data from 2016, baseline data from 2019, and follow-up data from 2019 to 2022. Our outcome was loss of healthy life expectancy, defined as incident functional disability or death. Our exposure was CGPs participation. Logistic regression models estimated odds ratios, adjusting for pre-exposure covariates. We applied a moderator-wide approach to assess effect modification by sociodemographic characteristics.</div></div><div><h3>Results</h3><div>Participation in CGPs was associated with lower odds of the incidence functional disability or death (OR, 0.88; 95 % CI, 0.79–0.98). Stratified analyses suggested stronger associations in subgroups including women, older adults (≥75), individuals with lower education or income, unemployed, living alone and rural residents. However, formal tests did not detect statistically significant effect modification.</div></div><div><h3>Conclusion</h3><div>Participation in CGPs may promote healthy aging across diverse older populations. These findings support CGPs as an equitable and scalable strategy for improving population health. Future research should involve longer follow-up periods and explore more dimensions of heterogeneity.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106060"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status and frailty in rheumatoid arthritis: A multicenter observational study (T-FLAG)","authors":"Mochihito Suzuki ,&nbsp;Shuji Asai ,&nbsp;Yoshifumi Ohashi ,&nbsp;Yasumori Sobue ,&nbsp;Kenya Terabe ,&nbsp;Shiro Imagama","doi":"10.1016/j.archger.2025.106073","DOIUrl":"10.1016/j.archger.2025.106073","url":null,"abstract":"<div><h3>Objective</h3><div>Frailty is a relevant clinical issue in rheumatoid arthritis (RA) patients, particularly as the population ages. Malnutrition, decreased physical function, and a loss of social connections are key contributors to frailty. This study aimed to investigate the association of nutritional status with frailty in RA patients, with a focus on physical function and social frailty.</div></div><div><h3>Methods</h3><div>This cross-sectional study examined RA patients from a multicenter cohort at three hospitals. Nutritional status was assessed using the Geriatric Nutritional Risk Index (GNRI). Frailty was defined using the Kihon Checklist, physical function using the Health Assessment Questionnaire Disability Index (HAQ-DI), and social frailty using the Makizako Social Frailty Index. Multivariate logistic regression was performed to identify independent associations with frailty.</div></div><div><h3>Results</h3><div>A total of 667 patients were included (median age, 72 years; 73 % women). Frailty prevalence increased progressively with worsening nutritional status (GNRI), from 29.6 % in the no risk group to 66.7 % in the major risk group (<em>P</em> &lt; 0.001). In multivariate models, GNRI and social frailty were significantly associated with frailty. This association, however, was no longer significant after adjusting for HAQ-DI, suggesting that physical function may influence this relationship. Stratified analysis confirmed that poor nutritional status was associated with increased frailty prevalence even among patients in HAQ remission (HAQ-DI ≤0.5).</div></div><div><h3>Conclusion</h3><div>Nutritional status is associated with frailty in RA patients, and this association may be influenced by physical function. A multidimensional approach addressing nutrition, physical function, and social factors is warranted in RA management.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106073"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between obesity and the transitions of frailty based on multi-state Markov model: A prospective study","authors":"Bosen Lv ,&nbsp;Xiaohui Li ,&nbsp;Qianning Lu ,&nbsp;Xiangjie Kong ,&nbsp;Bixuan Liu ,&nbsp;Yan Wu ,&nbsp;Liying Jing ,&nbsp;Jingyi Wang ,&nbsp;Wenjing Feng ,&nbsp;Yili Wu","doi":"10.1016/j.archger.2025.106074","DOIUrl":"10.1016/j.archger.2025.106074","url":null,"abstract":"<div><h3>Background</h3><div>New evidence has revealed the dynamic transition characteristics of frailty. However, the potential differences in the effects of different types of obesity on the transition of frailty remain unclear. This prospective study aims to assess the association between obesity-related indicators and frailty transition in older adults.</div></div><div><h3>Methods</h3><div>This study included 2375 individuals aged ≥60, excluding underweight ones from the English Longitudinal Study of Aging (ELSA) 2008–2016. Frailty was assessed via a 60-item frailty index. Obesity was rated by 4 indicators including body mass index (BMI), waist circumference (WC), conicity index, and body roundness index (BRI). Using multi-state Markov model to evaluate how the obesity affected the probability of frailty state transitions.</div></div><div><h3>Results</h3><div>During 8 years follow-up, 2517 frailty transitions were observed, with 1484 worsening and 1033 improving. Compared with normal participants, people with obesity were linked to higher risks of deterioration (non-frail to pre-frail: <em>HR</em>_BMI=1.32, 95 % <em>CI</em>=1.07–1.63, <em>HR</em>_WC=1.16, 95 % <em>CI</em>=1.00–1.35; pre-frail to frail: <em>HR</em>_BMI=1.90, <em>CI</em>=1.30–2.78; <em>HR</em>_WC=1.36, 95 % <em>CI</em>=1.03–1.81) and reduced likelihood of recovery (pre-frail to non-frail: <em>HR</em>_BMI=0.52, <em>CI</em>=0.40–0.67, <em>HR</em>_WC=0.66, <em>CI</em>=0.55–0.80). Compared with the low tertiles, the high tertiles of conicity index or BRI similarly accelerated the deterioration (non-frail to pre-frail: <em>HR</em>_{conicity index}=1.29, 95 % <em>CI</em>=1.04–1.59, <em>HR</em>_BRI=1.45, 95 % <em>CI</em>=1.20–1.76; pre-frail to frail: <em>HR</em>_BRI=1.58, 95 % <em>CI</em>=1.13–2.20) and hindered the recovery (pre-frail to non-frail: <em>HR</em>_{conicity index}=0.67, 95 % <em>CI</em>=0.53–0.84, <em>HR</em>_BRI=0.57, 95 % <em>CI</em>=0.46–0.72).</div></div><div><h3>Conclusions</h3><div>Different types of obesity all show that they accelerate the deterioration of frailty and hinder their ability to recover from frailty among older adults in UK.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106074"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of branched-chain amino acid-rich nutritional supplements combined with resistance training on body composition and body function in older patients with sarcopenia","authors":"Haoran Li ,&nbsp;Runfa Zhang ,&nbsp;Yongye Ma ,&nbsp;Jiaxin He ,&nbsp;Guoxing Li ,&nbsp;Jian Sun ,&nbsp;DuanyingLi","doi":"10.1016/j.archger.2025.106063","DOIUrl":"10.1016/j.archger.2025.106063","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia impairs self-care ability in older adults. While branched-chain amino acids (BCAAs)/leucine enhance muscle protein synthesis and resistance training promotes muscle growth, the combined effect on sarcopenia remains unclear. This meta-analysis evaluates whether combining resistance training with BCAA-rich supplements synergistically improves body composition and function in sarcopenic elders.</div></div><div><h3>Methods</h3><div>We systematically searched four databases and analyzed outcomes using Stata 18.0. Standardized mean differences (SMDs) were calculated via random-effects models.</div></div><div><h3>Results</h3><div>Twelve randomized trials (<em>n</em> = 459) were included. Only skeletal muscle index significantly improved with combined intervention vs. control (SMD = 0.337, 95 % CI [0.035,0.639], <em>p</em> = 0.029). No significant differences were found in: hand grip strength (SMD = 0.289, <em>p</em> = 0.080), 30-s chair stand (SMD = -0.794, <em>p</em> = 0.169), SPPB (SMD = -0.321, <em>p</em> = 0.124), walking speed (SMD = 0.344, <em>p</em> = 0.283), knee extension strength (SMD = 0.332,<em>p</em> = 0.328), total lean mass (SMD = 0.024, <em>p</em> = 0.908), or fat mass (SMD = -0.036, <em>p</em> = 0.866; all <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>BCAA supplementation post-resistance training only increased skeletal muscle index in older adults, without improving other functional or body composition outcomes.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106063"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting α7nAChR mitigates vascular aging and endothelial cell senescence through inhibiting oxidative stress and inflammation via α7nAChR/Nrf2/HO-1 signaling pathway","authors":"Rui Ma ,&nbsp;Yawen Zhang ,&nbsp;Wencheng Wang ,&nbsp;Qian Deng ,&nbsp;Chi Cao ,&nbsp;Shulin Li ,&nbsp;Lei Shi ,&nbsp;Chunyang Yu ,&nbsp;Yinhua Yu ,&nbsp;Jianying Tian","doi":"10.1016/j.archger.2025.106064","DOIUrl":"10.1016/j.archger.2025.106064","url":null,"abstract":"<div><div>Vascular aging is recognized as critical factor contributing to the onset and progression of cardiovascular diseases, which represent a leading cause of morbidity and mortality worldwide. The α7 nicotinic acetylcholine receptor (α7nAChR) exhibits widespread expressed in the cardiovascular system and is intricately linked to a diverse array of pathologies, in cardiovascular, conditions. Research indicates that oxidative stress plays a crucial role in exacerbating endothelial dysfunction and promoting vascular aging. However, less is known regarding the role of α7nAChR in vascular aging. In this study, we employed a combination of cellular experiments, animal models, and molecular biological techniques, utilizing an agonist (PNU282987) and antagonists (Malondialdehyde, MLA) of α7nAChR as pharmacological tools to investigate the role of α7nAChR in aging-related pathologies. The expression of α7nAChR in vascular tissue decreases with age both in rats and humans. Activation of α7nAChR alleviated vascular aging in aged rats, as evidenced by improving endothelium-dependent vasodilatation and endothelial continuity, decreased senescence-associated β-galactosidase activity, phosphorylation of H2A.X^Ser139, expression of p21 and p16INK4a and inflammation, Notably, effective activation of the α7nAChR mediated Nrf2/HO-1 signaling pathway and antioxidant activity by specific agonist, PNU282987, conversely, which were blocked by the α7nAChR-selective inhibitor MLA. The findings highlight the vital role of α7nAChR receptor in preserving vascular health and endothelial integrity in the development of vascular aging, Consequently, targeting the α7nAChR/Nrf2/HO-1 signaling pathway could serve as a potential therapeutic approach for the development of novel anti-aging strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"141 ","pages":"Article 106064"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}