Archives of gerontology and geriatrics最新文献

{"title":"Understanding physical aging in relation to biological aging, telomere length: A systematic review","authors":"Kyi Mar Wai ,&nbsp;Arkar Min Paing ,&nbsp;Thinzar Swe","doi":"10.1016/j.archger.2025.105854","DOIUrl":"10.1016/j.archger.2025.105854","url":null,"abstract":"<div><h3>Background</h3><div>Telomere length (TL) serves as a marker for biological aging, influenced by chronological aging but distinct from it. This systematic review aims to synthesize the evidence on the associations between components of physical aging and TL in the elderly population.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in online databases of PubMed, Web of Science, ProQuest, and ScienceDirect to identify the eligible papers published until 1st August 2024. The authors independently extracted data using the standardized form. The quality of the included studies was evaluated for the risks of biases.</div></div><div><h3>Results</h3><div>A total of 1080 records were initially identified using the predefined search strategy. A total of 40 eligible records were included in this review. When assessing physical aging, the nature and type of measurements across studies vary, including subjective, objective, and a combination of both approaches. Subjective assessments of general health or physical limitations may be linked with TL, while frailty, whether measured subjectively or objectively, shows associations with TL in less than 35 percent of total studies. In contrast, composite measures of physical performance/ability are consistently associated with TL in the elderly population.</div></div><div><h3>Conclusions</h3><div>In conclusion, we demonstrated that the associations between physical aging and TL varies depending on the type and nature of physical aging assessments. Composite measures of physical performance/ability demonstrate a strong and consistent parameter of physical aging to link with TL. Future research should prioritize standardized, multidimensional approaches to measure physical aging to understand better its association with TL to support healthy aging strategies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105854"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wakefulness after sleep offset and the elevated risk of mortality in older adults with evening preferences: A community-based 5-year longitudinal study","authors":"Georg von Fingerhut,&nbsp;Keitaro Makino,&nbsp;Osamu Katayama,&nbsp;Ryo Yamaguchi,&nbsp;Daiki Yamagiwa,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.archger.2025.105852","DOIUrl":"10.1016/j.archger.2025.105852","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>This study investigated the relationship between wakefulness after sleep offset timing (WASF), evening chronotype preferences, and mortality risk in community-dwelling older adults.</div></div><div><h3>Research design and methods</h3><div>We conducted a community-based longitudinal study with a sample of 4167 older adults aged ≥60. The sleep characteristics, WASF, subjective chronotype preferences, and other relevant variables of the participants at baseline were evaluated. We examined the association between WASF and mortality over a 5-year period using Cox proportional hazards models, with stratification by subjective chronotype preferences to explore potential effect modification.</div></div><div><h3>Results</h3><div>Data from 3734 participants were analyzed (71.1 ± 6.9 years; 2114 [56.6 %] women). The 5-year mortality incidence was 6.3 %. Overall, participants had a median (IQR) of 5.0 (2–20) min WASF, and 767 (20.6 %) were evening types. WASF of ≤5 min = 10.6 (95 % CI, 8.9–12.8), WASF of &gt;5 min = 14.6 (95 % CI, 12.1–17.6). The mortality incidence rates per 1000 person-years were: WASF of ≤5 min = 10.6 (95 % CI, 8.9–12.8) and WASF of &gt;5 min = 14.6 (95 % CI, 12.1–17.6). Even after adjusting for covariates, the longer WASF participants had a higher hazard ratio of 1.40 (95 % CI, 1.04–1.88) compared to the shorter WASF participants. Regular, prolonged WASF was found to be significantly associated with an increased risk of mortality among evening-type individuals (2.69; 95 % CI: 1.19–6.08) in the stratified model based on subjective chronotype preferences. However, we found no statistically significant association among the other types.</div></div><div><h3>Discussion and implications</h3><div>Reducing morning time in bed, and addressing prolonged WASF are crucial factors in decreasing mortality risk among older adults, especially among those with evening preferences.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105852"},"PeriodicalIF":3.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clearing the confounding confusion: Benzodiazepines and the risk of dementia?","authors":"Kevin J Friesen ,&nbsp;Jamie Falk ,&nbsp;I Fan Kuo ,&nbsp;Alexander Singer ,&nbsp;Shawn Bugden","doi":"10.1016/j.archger.2025.105850","DOIUrl":"10.1016/j.archger.2025.105850","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the relationship between duration of benzodiazepine exposure and the risk of dementia.</div></div><div><h3>Design</h3><div>A retrospective cohort study using administrative health data followed 3 age-based strata (ages 55, 65 and 75) for up to a maximum of 22 years to examine risk of dementia due to benzodiazepine use. Each stratum was analyzed as a whole, then restricted to persons with depression or anxiety, and finally using high dimension propensity scores (HDPS) matched cohort.</div></div><div><h3>Setting</h3><div>We used administrative data on subjects receiving standard medical care in Manitoba, Canada.</div></div><div><h3>Measurements</h3><div>Prescription data was used to quantify benzodiazepine using cumulative defined-daily-dose (DDD). Comorbidities and cases of dementia were determined using medical and hospital data.</div></div><div><h3>Results</h3><div>Dementia risk in high-dose users of the youngest strata was elevated compared to non-users (adjusted HR (aHR) 1.33; 95 % CI 1.05–1.68)). Little to no difference was found in the middle (aHR 1.17; 1.02–1.33) and oldest strata (aHR 1.02; 0.93–1.11). Restriction to persons with depression or anxiety eliminated the association. No association was found using HDPS-matched comparison groups.</div></div><div><h3>Conclusions</h3><div>Only a modest increase in dementia risk was seen in the high-dose benzodiazepine users. This association appears to be driven by the confounding due to higher rates of diabetes, cardiovascular disease, depression, and anxiety among users. Using restriction or HDPS to better control for confounding effects eliminates the association. While benzodiazepines do not appear to be a significant risk factor for dementia, tolerance, dependency and adverse effects caution against their long-term use.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105850"},"PeriodicalIF":3.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effects of Otago Exercise Program and Aquatic Exercise on Fall Risk in Older Adults: A Systematic Review”. [Archives of Gerontology and Geriatrics, 2025: 105799.]","authors":"Mingyuan Dong ,&nbsp;Xi Liu ,&nbsp;Yongchul Choi ,&nbsp;Ning Li","doi":"10.1016/j.archger.2025.105838","DOIUrl":"10.1016/j.archger.2025.105838","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105838"},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple chronic conditions and polypharmacy in cognitively unimpaired older adults are associated with subsequent cognitive decline: results from the national alzheimer's coordinating center data","authors":"Chooza Moon ,&nbsp;Meina Zhang ,&nbsp;Boxiang Wang ,&nbsp;Sue E. Gardner ,&nbsp;Joel C. Geerling ,&nbsp;Karin F. Hoth","doi":"10.1016/j.archger.2025.105846","DOIUrl":"10.1016/j.archger.2025.105846","url":null,"abstract":"<div><div>Prior cross-sectional studies revealed that multiple chronic conditions (MCC) and polypharmacy are associated with cognitive impairment. The purpose of this study was to determine whether the number of chronic conditions and the number of medications are associated with longitudinal changes in cognition (memory, attention/working memory, semantic ability/language, processing speed, executive function). We analyzed data from 5671 individuals (age 71.4 ± 9.3, 68 % female) from the National Alzheimer's Coordinating Center database who were cognitively unimpaired at baseline and had 3 or more subsequent visits. 57 % had more than two chronic conditions, and 44 % were taking 5 or more medications at baseline. At baseline, we observed that individuals with MCC had lower memory, attention/working memory, semantic ability/language, processing speed, and executive function performance than those without MCC. Using mixed-effect modeling approaches, we found that having a higher number of chronic conditions was associated with greater decline in semantic ability/language and executive function, and having a higher number of medications was associated with greater decline in attention/working memory, semantic ability/language, and executive function. The findings suggest that healthcare professionals and service providers should be conscious of the fact that patients dealing with MCC and those on multiple medications are vulnerable and require careful monitoring. Future studies are warranted using more comprehensive multimorbidity data and advanced analytic approaches, and prospective, controlled trials are warranted to test whether managing MCC and reducing the number of unnecessary medications or certain medications can prevent decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105846"},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and burden of age-related hearing loss: 32-year study","authors":"Lingkang Dong ,&nbsp;Wenqi Dong ,&nbsp;Shihui Zhang ,&nbsp;Yuchen Jin ,&nbsp;Yumeng Jiang ,&nbsp;Zhuangzhuang Li ,&nbsp;Chunyan Li ,&nbsp;Dongzhen Yu","doi":"10.1016/j.archger.2025.105847","DOIUrl":"10.1016/j.archger.2025.105847","url":null,"abstract":"<div><h3>Background</h3><div>Age-related hearing loss (ARHL) is a major cause of disability and diminished quality of life in older adults. This study uses data from the 2021 Global Burden of Disease (GBD) study to assess global ARHL.</div></div><div><h3>Methods</h3><div>We evaluated ARHL prevalence, DALYs (Disability-Adjusted Life Years), ASPR (Age-Standardized Prevalence Rate), and ASDR (Age-Standardized DALYs Rate). Trend analysis was conducted using Estimated Annual Percentage Change (EAPC), with projections to 2050.</div></div><div><h3>Result</h3><div>From 1990 and 2021, global ARHL prevalence cases and DALYs increased by 109 %, reaching 1.55 billion and 44.45 million, respectively. The ASPR increased from 17,106.88 to 18,070.26, while the crude prevalence rate significantly from 13,890.66 to 19,587.14. Both ASPR and ASDR demonstrated significant age-related increases, particularly for moderate and moderately severe ARHL, with EAPC values of 1.39 and 1.49 for ASDR, respectively. Among individuals aged over 85 years, the ASPR of ARHL is expected to reach 80 %. Prevalence cases peaked in the 55–69 age group, with the highest number of cases (179.43 million) observed in the 55–59 subgroup. High-middle SDI regions and East Asia exhibited the most rapid growth. By 2050, ARHL cases are projected to reach 2.31 billion, with ASPR and ASDR expected to continue rising.</div></div><div><h3>Conclusion</h3><div>ARHL has increased globally over the past three decades, largely due to population aging. The burden is most severe in middle SDI regions, East Asia, and the 55–69 age group, primarily due to their substantial population bases. Addressing this escalating challenge requires enhanced public awareness, early screening initiatives, and targeted interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105847"},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative blood pressure burden and the risk of functional dependence in elderly cohorts: An exploration of the influencing factors","authors":"Yanfen Hu ,&nbsp;Junxia Yu ,&nbsp;Zhenjie Xu ,&nbsp;Lingxia Li","doi":"10.1016/j.archger.2025.105849","DOIUrl":"10.1016/j.archger.2025.105849","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the correlation between cumulative blood pressure levels and functional dependence in individuals aged 60 and older.</div></div><div><h3>Methods</h3><div>Data were sourced from two distinct elderly databases: CHARLS and ELSA. Various statistical techniques, including logistic regression analysis, restricted cubic spline analysis, forest plot visualization, and interaction analyses, were employed to delve into the associations between cumulative blood pressure and difficulties in performing activities of daily living.</div></div><div><h3>Results</h3><div>Across both cohorts, there was a discernible trend towards an increased risk of ADL difficulties with escalating cumulative blood pressure levels. Logistic regression analysis confirmed a statistically significant relationship between cumulative blood pressure and ADL difficulties (<em>P</em> &lt; 0.001). The results derived from restricted cubic spline plots further underscored this relationship, demonstrating that, after adjusting for a multitude of confounding factors, the risk of ADL difficulties augmented with rising cumulative blood pressure. Additionally, the forest plot and interaction plot findings revealed that the association between heightened cumulative blood pressure and the risk of ADL difficulties was contingent upon factors such as body mass index, gender, and memory-related disorders.</div></div><div><h3>Conclusions</h3><div>Our findings indicate a positive correlation between cumulative blood pressure and the risk of experiencing difficulties with ADLs. Furthermore, this association appears to be modulated by BMI, gender, and the presence of memory-related diseases.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105849"},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of metabolic dysfunction-related fatty liver disease and dementia risk: A prospective study based on the UK biobank","authors":"Chaofan Geng ,&nbsp;Peiyang Gao ,&nbsp;Yi Tang","doi":"10.1016/j.archger.2025.105845","DOIUrl":"10.1016/j.archger.2025.105845","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention for its potential link with dementia. This study aims to investigate the association between MAFLD and dementia, including its subtypes, to address existing knowledge gaps.</div></div><div><h3>Methods</h3><div>A total of 415,116 participants from the UK Biobank were included, with standardized screening criteria used to determine MAFLD diagnosis. Cox regression was employed to assess the relationship between MAFLD and dementia risk. Subgroup analyzes were conducted to provide further insights into the impact of MAFLD on dementia risk, and the mediation effect of inflammation was evaluated.</div></div><div><h3>Results</h3><div>Among the 150,509 MAFLD patients, there was a significantly elevated risk of dementia, with hazard ratios (HR) of 1. 526 (95 % CI = 1. 460–1. 596) for all-cause dementia, 1. 356 (95 % CI = 1. 266–1. 453) for Alzheimer's disease (AD), and 2. 206 (95 % CI = 2. 000–2. 434) for vascular dementia (VaD). MAFLD patients showed a significant reduction in gray matter volume in MAFLD patients (β = -0. 07, 95 % CI = -0. 17, -0. 01) and a marked increase in deep white matter lesion volume (<em>P</em> &lt; 0. 001). Elevated inflammatory markers in MAFLD patients accounted for a mediation effect of 30. 8 %<strong>.</strong></div></div><div><h3>Conclusion</h3><div>MAFLD substantially increases the risk of dementia, underscoring the importance of early intervention and prevention strategies targeting MAFLD to reduce dementia incidence.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105845"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, awareness, behaviours, beliefs, attitudes, and perceptions of older Australians regarding muscle health and sarcopenia: A national survey","authors":"Robin M. Daly,&nbsp;David Scott,&nbsp;Nicole Kiss,&nbsp;Michael Tieland,&nbsp;Brenton Baguley,&nbsp;Jackson J. Fyfe","doi":"10.1016/j.archger.2025.105835","DOIUrl":"10.1016/j.archger.2025.105835","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated older Australians understanding, awareness, knowledge, perceptions, behaviours, beliefs and attitudes towards muscle health and sarcopenia, and barriers towards exercise and nutrition as prevention options.</div></div><div><h3>Methods</h3><div>A national, anonymous 41-question, online purpose-designed survey covering the concepts outlined in the study objective was conducted from March-May 2024.</div></div><div><h3>Results</h3><div>1261 adults (≥50-y) aged 50–94 years participated. Low muscle strength and poor function were the most common criteria associated with poor muscle health. Knowledge of common signs/symptoms, risk factors, consequences, and effective treatments was generally high. However, there was uncertainty about unintentional weight loss as a risk factor, increased risk for infection/reduced immunity and chronic conditions as consequences, and ineffective treatments options (only 5–12 % recognised any form of exercise, aerobic exercise and eating more fruits/vegetables as ineffective treatments). Only 8.9 % reported their doctor had discussed muscle health but 82–95 % would act if they received information on risk factors or if informed they were at risk for poor muscle health. Two-thirds recognised sarcopenia as a serious condition, with 48 % concerned about its potential impact, despite 90 % acknowledging muscle health is very important to maintain. Only around half believed they had sufficient knowledge and confidence to adopt lifestyle changes to reduce their risk, with motivation the leading barrier to engaging in exercise or dietary strategies to optimize muscle health.</div></div><div><h3>Conclusion</h3><div>Older Australians recognize the importance of muscle health, understand key strategies to manage it and would act if identified to be at risk, but many lack knowledge and confidence to adopt lifestyle changes to improve their muscle health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"135 ","pages":"Article 105835"},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence applications and aging (1995–2024): Trends, challenges, and future directions in frailty research","authors":"Ali Mufraih Albarrati ,&nbsp;Rakan Nazer ,&nbsp;Siddig Ibrahim Abdelwahab ,&nbsp;Mohammed Albratty","doi":"10.1016/j.archger.2025.105837","DOIUrl":"10.1016/j.archger.2025.105837","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, a significant predictor of adverse health outcomes, has become a focal point of research, particularly with the advent of artificial intelligence (AI) technologies. This study aimed to provide a comprehensive bibliometric analysis of research trends in AI and frailty to map conceptual developments, collaborations, and emerging themes in the field.</div></div><div><h3>Methods</h3><div>A systematic search was conducted using the Scopus database employing a comprehensive set of keywords related to AI and frailty. The search was refined to include only original articles in English, yielding 1213 documents. Data extraction was performed in October 2024 and exported in the CSV and BibTeX formats. Annual growth trends were analyzed using Microsoft Excel, while VOSviewer and R-package were used for bibliometric analyzes and visualization to identify key contributors, collaborations, and thematic clusters.</div></div><div><h3>Results</h3><div>The analysis revealed rapid growth in research publications, with AI applications in frailty gaining prominence over the past decade. Thematic clusters highlight areas such as predictive modeling, machine learning applications, and geriatric care innovations. The United States, United Kingdom, and Italy emerged as leading contributors to publications and collaborations. The key topics included prediction models, dementia, sarcopenia, and rehabilitation. This bibliometric study underscores the increasing integration of AI into frailty research, revealing key trends, collaborative networks, and emerging areas of focus.</div></div><div><h3>Conclusion</h3><div>These findings can guide future research, foster collaborations, and enhance the application of AI technologies to improve frailty assessment and management.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105837"},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}