Archives of gerontology and geriatrics最新文献

{"title":"CircRSU1 contributes to the development of osteoarthritis via the miR-345-3p/TRAF6 signaling","authors":"Yinan Zhao ,&nbsp;Yingchun Wang ,&nbsp;Mo Li,&nbsp;Zhiquan Li","doi":"10.1016/j.archger.2024.105696","DOIUrl":"10.1016/j.archger.2024.105696","url":null,"abstract":"<div><div>Objective: Osteoarthritis (OA) is a common type of prevalent joint diseases in the elderly. At present, circular RNAs receive more attention due to their roles during the progression of OA. In this paper, the expression profiles of circRSU1 and relevant molecules in OA patients and cell models were evaluated, and the underlying regulatory mechanisms of circRSU1-modulated OA development were also explored. Methods: The proliferation of chondrocytes was examined using CCK-8 assay. The levels of relevant proteins were evaluated by western blotting. The production of pro-inflammatory cytokines were measured by ELISA. Results: The results revealed upregulation of circRSU1 in OA samples, and IL-1β treatment could elevate the expression of circRSU1 in human chondrocytes. In addition, knockdown of circRSU1 abolished the dysfunctions caused by IL-1β in chondrocytes. Furthermore, miR-345–3p was identified as the novel downstream molecule of circRSU1. The levels of miR-345–3p were notably decreased in cells transfected with oe-circRSU1 and elevated in cells treated with si-circRSU1, respectively. Moreover, si-circRSU1 was able to attenuate IL-1β-induced impairments in chondrocyte via miR-345–3p. In addition, to verify the downstream mechanisms of circRSU1-modulated OA progression, TRAF6 was identified as the putative target of miR-345–3p, and miR-345–3p inhibition abolished circRSU1 knockdown-triggered downregulation of TRAF6 in IL-1β-induced OA cell model. In addition, miR-345–3p protected chondrocytes from IL-1β-induced dysfunction such as impaired ECM, reduced proliferation and upregulated apoptosis of chondrocytes, and elevated production of proinflammatory cytokines through regulating TRAF6. Conclusion: In summary, circRSU1 was able to contribute to the progression of OA through regulating the miR-345–3p/TRAF6 pathway, and this novel signalling could be novel candidate for targeted therapy for OA patients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105696"},"PeriodicalIF":3.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of wearable sensors in constructing a fall risk prediction model for community-dwelling older adults: A scoping review","authors":"Bingqing Wang,&nbsp;Yiwen Liu,&nbsp;Aming Lu,&nbsp;Cenyi Wang","doi":"10.1016/j.archger.2024.105689","DOIUrl":"10.1016/j.archger.2024.105689","url":null,"abstract":"<div><h3>Background</h3><div>Falls are a particularly important public health problem among older people. Early identification of risk factors is crucial for reducing the risk of falls in older adults. Studies have confirmed the effectiveness of sensor-based fall risk prediction models for the older population. This article aims to sort out the current use of wearable sensors in building fall risk models for older adults in the community and explore the suitable use of sensors in model construction and the prospects and possible difficulties of model application.</div></div><div><h3>Methods</h3><div>This scoping review was conducted from 26 November 2023 to 9 March 2024. It was searched through Web of Science, PubMed, OVID, EBSCO and CNKI using the terms “wearable sensor” or “inertial sensor” or “inertial motion capture” or “wearable electronic devices” or “IMU” or “MEMS” or “accelerometer” or “gyroscope” or “magnetometer” or “smartphone” and “fall” and “predict” or “prediction” and “older adults” or “older men” or “older women” or “elderly” and “community” or “neighborhood” or “dwelling”.</div></div><div><h3>Results</h3><div>Thirty-one articles were included, and the selection of sensor type, location, and other characteristics and indicators, as well as model types, was summarized.</div></div><div><h3>Discussion and Conclusions</h3><div>Wearable sensors with a frequency of 100 Hz located in a combination of spine/ pelvis/ hip-shank-feet position is recommended. In addition, walking tests and TUG and its variants are appropriate in the community. However, more empirical research is needed to obtain the best model construction combination and apply it effectively to the community.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105689"},"PeriodicalIF":3.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enalapril induces muscle epigenetic changes and contributes to prevent a decline in running capacity in spontaneously hypertensive rats","authors":"Denis Carlos dos Santos ,&nbsp;Fernando Henrique Ferrari Alves ,&nbsp;Luiz Fernando Veríssimo ,&nbsp;Hiviny Ataides Raquel ,&nbsp;Vinicius Lucca Volpini ,&nbsp;Leonardo André da Costa Marques ,&nbsp;Marli Cardoso Martins-Pinge ,&nbsp;Karen Barros Parron Fernandes ,&nbsp;Karoliny Coelho Andrade ,&nbsp;Lisete Compagno Michelini ,&nbsp;Gislaine Garcia Pelosi","doi":"10.1016/j.archger.2024.105699","DOIUrl":"10.1016/j.archger.2024.105699","url":null,"abstract":"<div><div>Drugs such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers can improve muscle function and exercise capacity, as well as preventing, attenuating or reversing age-related losses in muscle mass, however, the exact mechanisms by which these drugs affect muscle cells, are not yet fully elucidated. Moreover, the potential epigenetic alterations induced in skeletal muscle tissue are also largely unexplored. The aim of this study was to evaluate if enalapril or losartan can change the physical performance and epigenetic profile of skeletal muscle in spontaneously hypertensive rats (SHRs). Male SHRs were treated with water, enalapril (10/mg/kg/day) or losartan (10/mg/kg/day) for 28 consecutive days and submitted to progressive testing on a treadmill. Body weight, perigonadal and retroperitoneal fat, mean arterial pressure, heart rate, running distance and global DNA methylation in the gastrocnemius and soleus muscles were evaluated. Enalapril reduced the rate of weight gain, as well as reducing retroperitoneal fat (<em>p</em> &lt; 0.05) and MAP (<em>p</em> &lt; 0.05) and avoiding the decline in running distance when compared to the other groups (<em>p</em> &gt; 0.05), even 7 days after the end of treatment (<em>p</em> &gt; 0.05). Moreover, enalapril increased global DNA methylation in gastrocnemius muscle cells (<em>p</em> &lt; 0.01). No effects were observed in the losartan-treated group. Our data showed that enalapril prevented the decline in physical function in SHR, as well as reduced the rate of weight gain of the animals. In addition, the results showed, alterations in the global DNA methylation of skeletal muscle cells skeletal structures of the gastrocnemius muscle.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105699"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, determinants, and health outcomes of potentially inappropriate medication use according to the 2023 beers criteria among hospitalised older patients","authors":"Kittipak Jenghua ,&nbsp;Sirayut Phatthanasobhon ,&nbsp;Duangkamon Poolpun","doi":"10.1016/j.archger.2024.105693","DOIUrl":"10.1016/j.archger.2024.105693","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to determine the prevalence, determinants, and rehospitalisation outcomes of potentially inappropriate medication (PIM) use among hospitalised older patients.</div></div><div><h3>Design and participants</h3><div>This retrospective cohort study analysed older patients admitted to a tertiary care hospital from 2021 to 2023. We evaluated PIM prescriptions using the 2023 Beers criteria, classifying the patients as PIM users or non-users. We assessed the prevalence of PIM use, identified its determinants, and investigated the association between PIM use and rehospitalisation for any reason within one year of discharge, as well as the related length of stay and total medical costs.</div></div><div><h3>Results</h3><div>The study comprised 20,629 hospitalised older patients with a mean age of 71.17 ± 8.14 years, 50.21% of whom were women. PIM usage was prevalent among 91.32% of the patients. The determinants of PIM use included being female, having a longer hospital stay, an increasing number of prescribed drugs, and three or more chronic conditions. However, the use of PIM did not significantly increase the risk of rehospitalisation (adjusted hazard ratios = 1.02; 95% CI = 0.87–1.19), length of stay (adjusted mean difference [aMD] = 0.35 days; 95% CI = -1.31 to 2.01 days), or cost of medical care (aMD = 2,039 Baht; 95% CI = -9,824 to 13,901 Baht).</div></div><div><h3>Conclusions</h3><div>The use of PIMs among hospitalised older patients remains alarmingly high and is strongly correlated with the number of prescribed drugs. However, no significant link was found between PIM use and rehospitalisation outcomes within a one-year period.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105693"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular mechanisms of steroid hormone effects on cognitive function","authors":"Hai Duc Nguyen ,&nbsp;Giang Huong Vu ,&nbsp;Woong-Ki Kim","doi":"10.1016/j.archger.2024.105684","DOIUrl":"10.1016/j.archger.2024.105684","url":null,"abstract":"<div><h3>Objective</h3><div>There is a lack of information on the molecular mechanisms by which steroid hormones (testosterone, estrogen, and progesterone) regulate cognitive impairment. Thus, we aimed to identify the protective effects of steroid hormones on cognitive function.</div></div><div><h3>Methods</h3><div>We analyzed the literature on the molecular mechanisms, biological activities, physicochemical properties, and pharmacokinetics of steroid hormones.</div></div><div><h3>Results</h3><div>Steroid hormones can protect against cognitive impairment by regulating key genes (INS, TNF, STAT3, ESR1). Specific microRNAs, namely hsa-miR-335-5p, hsa-miR-16-5p, and hsa-miR-26b-5p, along with transcription factors NFKB1, PPARG, NR3C1, GATA2, EGR1, ATF3, and CEBPA, play a significant role in this protective mechanism. The involvement in cognitive processes, regulation of phosphorylation, neuronal apoptosis, and signaling pathways related to Alzheimer's disease significantly influence the protein-protein interaction network underlying these effects. Additionally, steroid hormones exhibit anti-hypercholesterolemic properties, anti-inflammatory activity, antitoxic properties, and function as inhibitors of acetylcholine neuromuscular transmission. They also hold promise as therapeutic agents for the treatment of dementia. Promising therapeutic interventions for cognitive impairment include the use of miRNA sponges targeting hsa-miR-16-5p, along with the administration of capsaicin, minocycline, dopamine, sertraline, and minaprine. The gut microbiota species <em>Lactobacillus amylovorus, Paraprevotella clara, Libanicoccus massiliensis, Prevotella oris, Turicibacter sanguinis</em>, and <em>Dubosiella newyorkensis</em> were identified as significant contributors to cognitive impairment and altered levels of steroid hormones.</div></div><div><h3>Conclusion</h3><div>Steroid hormones are promising compounds for improving cognitive function. Further research is needed to validate these findings through focused investigations into apoptosis, regulation of neuronal cell death, miRNA sponges, interactions with gut microbiota, and the potential efficacy of pharmaceutical agents.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105684"},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing of the Nrf2 pathway in aging promotes a decrease in the anti-inflammatory effect of resveratrol","authors":"Filipe Nogueira Franco,&nbsp;Brenda Evangelista Peixoto,&nbsp;Glaucy Rodrigues de Araújo,&nbsp;Miriam Martins Chaves","doi":"10.1016/j.archger.2024.105694","DOIUrl":"10.1016/j.archger.2024.105694","url":null,"abstract":"<div><div>During aging, in addition to increased oxidative stress, inflammation also occurs. A chronic and low-grade inflammation - called “inflammaging” - develops, which contributes to the etiology of diseases related to aging. Resveratrol (Resv.) is a polyphenol well known for its biologically active properties, such as antioxidant and anti-inflammatory properties. This balance can be regulated by Nrf2 - a transcription factor that regulates cellular defense against oxidative agents through the expression or inhibition of certain genes. The objective was to evaluate the effect of Nrf2 on the production of cytokines in leukocytes of different ages treated with resveratrol (5µm). The subjects were divided into three groups: 20–39, 40–59 and 60–80 years old. After separation of the leukocytes, a 24-hour treatment was carried out with and without ML385 inhibitor with the treatments: Control, Resv, Peroxide and Peroxide+Resv. 150 µM peroxide was set to develop an oxidative environment. Cytokines were measured by ELISA (*<em>p</em> &lt; 0.05). In general, there was an increase in TNF and IL-6 in cells stimulated with peroxide compared to controls. A decrease in these two cytokines was also observed in cells treated with resveratrol, both at basal levels and in an oxidizing environment (with peroxide). The polyphenol was able to increase IL-10 only in the youngest age groups. The same profile was observed comparing the same groups when the Nrf2 pathway was inhibited with ML385. It is concluded that resveratrol may have a better effect on preventing oxidation and inflammation present in aging, especially through the antioxidant and anti-inflammatory Nrf2 pathway.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105694"},"PeriodicalIF":3.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune-inflammation index and 2-year all-cause mortality in elderly patients with hip fracture","authors":"Shuhuai Tan ,&nbsp;Yu Jiang ,&nbsp;Kaihua Qin ,&nbsp;Yan Luo ,&nbsp;Dingfa Liang ,&nbsp;Yong Xie ,&nbsp;Xiang Cui ,&nbsp;Junsong Wang ,&nbsp;Houchen Lyu ,&nbsp;Licheng Zhang","doi":"10.1016/j.archger.2024.105695","DOIUrl":"10.1016/j.archger.2024.105695","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the association between systemic immune-inflammation index (SII) and 2-year all-cause mortality in elderly patients with hip fractures.</div></div><div><h3>Methods</h3><div>We performed a cohort study of hip fracture patients aged 65 years or older who received hip fracture surgery at a tertiary hospital from January 2005 to March 2022. The SII was calculated as: SII = (neutrophil count * platelet count) / lymphocyte count, based on the latest blood test before discharge. Patients were categorized into 3 groups according to SII tertiles: low SII group (≤770.92 × 10⁹/L), medium SII group (770.92 × 10⁹/L -1293.03 × 10⁹/L), and high SII group (&gt;1293.03 × 10⁹/L). The primary outcome was 2-year all-cause mortality. We evaluated the association between SII and 2-year all-cause mortality using the multivariate Cox regression model.</div></div><div><h3>Results</h3><div>Among 2766 patients, 296 patients died during the 2-year follow-up period. The incidence of 2-year all-cause mortality per 1000 persons was 90.0 (95 % CI: 73.2–110.2) in the low SII group, 86.8 (95 % CI: 70.3–106.7) in the medium SII group, and 144.3 (95 % CI: 123.1–168.5) in the high SII group. Compared with patients in the low SII group, the hazard ratio for 2-year all-cause mortality was 0.97 (95 % CI: 0.69–1.37) in the medium SII group and 1.47 (95 % CI: 1.07–2.01) in the high SII group (<em>P</em> for trend, 0.010).</div></div><div><h3>Conclusion</h3><div>SII is significantly associated with 2-year all-cause mortality in elderly patients with hip fracture. SII may be used to identify patients at high risk of mortality after hip fracture surgery.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105695"},"PeriodicalIF":3.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intrinsic capacity with incident type 2 diabetes mellitus in older Chinese: Guangzhou Biobank Cohort Study","authors":"Wei Xiang Gao ,&nbsp;Jia Liu ,&nbsp;Jiao Wang ,&nbsp;Ya Li Jin ,&nbsp;Shiu Lun Au Yeung ,&nbsp;Tai Hing Lam ,&nbsp;Wei Sen Zhang ,&nbsp;Lin Xu","doi":"10.1016/j.archger.2024.105687","DOIUrl":"10.1016/j.archger.2024.105687","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization introduced intrinsic capacity (IC) as a metric for healthy aging. However, we found no report on the association between IC and type 2 diabetes mellitus (T2DM). We investigated the association between IC and incident T2DM in older Chinese from the Guangzhou Biobank Cohort Study.</div></div><div><h3>Methods</h3><div>IC was assessed across five domains equally: locomotion, vitality, cognition, psychological and sensory. Composite IC scores (0–10) were classified into three groups: poor (0–5.9), fair (6.0–8.9), and high (9.0–10), with higher scores representing greater IC. Multivariable linear regression and cox regression was used to analyze the association between IC with glycemia and T2DM, respectively.</div></div><div><h3>Results</h3><div>Of 3582 participants with a mean age of 59.1 years (standard deviation (SD)=7.13) without baseline diabetes, during an average follow-up of 3.3 years (SD=0.86), 497 (13.87%) developed T2DM. After adjustments for potential confounders, those with baseline poor IC, versus high, had higher fasting glucose, 2-hour post-load glucose and glycosylated hemoglobin A_1c at follow-up, and a higher risk of incident T2DM (HR (95%CI): 1.80 (1.20, 2.72)). Among IC domains, only vitality impairment was associated with an increased risk of T2DM (P for trend &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>We first reported the prospective associations of poor IC and vitality with higher glycemia and incident T2DM risk. Enhancing muscle strength to improve functional ability may be a possible intervention for reducing future risk of T2DM in older populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105687"},"PeriodicalIF":3.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding loneliness after widowhood: The role of social isolation, social support, self-efficacy, and health-related factors","authors":"Rosanne Freak-Poli ,&nbsp;Htet Lin Htun ,&nbsp;Achamyeleh Birhanu Teshale ,&nbsp;Claryn Kung","doi":"10.1016/j.archger.2024.105692","DOIUrl":"10.1016/j.archger.2024.105692","url":null,"abstract":"<div><h3>Background</h3><div>Widowhood negatively affects trajectories of social isolation and loneliness. Given the inevitability of spousal bereavement for many, further investigation into potential modifiers of bereavement-related loneliness is warranted.</div></div><div><h3>Aim</h3><div>To examine the moderating effects of social isolation, social support, sociodemographic, self-efficacy, health, and quality of life factors on changes in loneliness before and after widowhood.</div></div><div><h3>Methods</h3><div>We analysed 19 waves of data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey, comprising 749 widowed and 8,418 married individuals (comparison). Coarsened exact matching weights were applied, controlling for age and time trends. Local polynomial smoothed plots illustrated social health trajectories from three years before to three years after spousal death. All analyses were gender-stratified.</div></div><div><h3>Results</h3><div>Low social isolation and higher social support did not prevent increased loneliness following widowhood. Men in major cities were less likely to experience reductions in social isolation during bereavement, despite being less socially-isolated at baseline than men in regional/remote areas. The bereavement-loneliness relationship was consistent across all subgroups. For men, this relationship was weakened by older age and being born in a non-English-speaking country, but strengthened by poverty and living in a regional/remote areas. For women, it was weakened by older age, and strengthened by factors such as being born in a non-English-speaking country, poverty, employment or volunteering, and having a long-term mental health condition.</div></div><div><h3>Conclusion</h3><div>Loneliness is a common and potentially unavoidable experience during widowhood, highlighting the importance of screening by healthcare workers to improve wellbeing and prevent future mental health issues.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105692"},"PeriodicalIF":3.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the relationship between participation in salons aimed at care prevention through the promotion of social participation and the subsequent cost of care: A 3-year prospective follow-up study in JAGES","authors":"Hiroshi Hirai ,&nbsp;Masashige Saito ,&nbsp;Tokunori Takeda ,&nbsp;Katsunori Kondo","doi":"10.1016/j.archger.2024.105688","DOIUrl":"10.1016/j.archger.2024.105688","url":null,"abstract":"<div><div>Many previous studies have found that social participation improves the health and functional maintenance of older people. However, to determine whether promoting social participation can prevent functional decline in the elderly, it is necessary not only to compare the prognosis of those who participate in social activities to those who do not but also to demonstrate that the intervention was effective in promoting social participation. Although the effect of social participation in preventing caregiving has been demonstrated, the key question is whether preventing functional decline through social participation can reduce care costs. This study aims to examine the relationship between participation in salons aimed at care prevention through the promotion of social participation and the subsequent cost of care. We use the Japan Gerontological Evaluation Study (JAGES) dataset to conduct longitudinal, individuallevel analysis. We focus on all residents 65 years and older who did not have a without disability in Taketoyo town and ran three regression analyses. First, a generalized linear model (GLM) with Tweedie distribution and log-link function, as well as robust estimation of variance components was used to estimate the dependent variables. Second, we used an inverse probability weighting (IPW) model to minimize selection bias. Finally, we performed the IV analysis. In this study, the GLM with IPW and IV models revealed link between salon participants and lower caregiving costs. The link between participation and caregiving costs was confirmed in a model with reduced selection bias, rather than in a simple GLM model.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105688"},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}