Archives of gerontology and geriatrics最新文献

{"title":"Association of childhood and adulthood socioeconomic status with frailty index trajectories: Using five-wave panel data from the China Health and Retirement Longitudinal Study (CHARLS)","authors":"Kai Zhang,&nbsp;Lirong Chai,&nbsp;Yi Zhang,&nbsp;Weijing Wang,&nbsp;Xiaolin Hu,&nbsp;Weizheng Kong,&nbsp;Dongfeng Zhang,&nbsp;Junning Fan","doi":"10.1016/j.archger.2025.105780","DOIUrl":"10.1016/j.archger.2025.105780","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between childhood and adulthood socioeconomic status (SES) and long-term frailty trajectories is unclear. We aimed to assess the frailty index (FI) dynamic trajectories and examine the associations between childhood and adulthood SES and frailty trajectories.</div></div><div><h3>Methods</h3><div>We included 7321 participants aged 45 and older from the 2011–2020 China Health and Retirement Longitudinal Study (CHARLS). Six childhood SES factors and four adulthood SES factors were included. Group-based trajectory modelling was used to identify frailty trajectories and multinomial logistic regression was used to assess the association between SES and frailty trajectories.</div></div><div><h3>Results</h3><div>Three frailty trajectory groups were identified: low-increase trajectory (LT, 59.9 %), moderate-increase trajectory (MT, 31.7 %) and high-increase trajectory (HT, 8.4 %). With the LT group as reference, for childhood SES, participants with an illiterate mother (relative-risk radio [RRR]=1.67, 95 % confidence interval [CI]: 1.10–2.52), having not enough food (1.67, 1.34–2.09), with family's financial situation (2.35, 1.61–3.42) and childhood health status (2.72, 2.09–3.53) worse than others had higher odds of being in the HT group. For adulthood SES, rural residence (1.86, 1.50–2.31), with an educational level of less than middle school (2.75, 1.83–4.15), had higher odds of being in the HT group. Similar results were found for people of different ages, genders, and residences.</div></div><div><h3>Conclusions</h3><div>Participants with lower SES, including maternal and self- low education, childhood hunger, worse family financial and childhood health status are more likely to experience a high-increase FI trajectory, i.e. aging faster. Attention should be paid to reduce early-life social inequalities thus to promote later-time healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105780"},"PeriodicalIF":3.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which pathway of the possible sarcopenia algorithm of the AWGS 2019 guideline is the best in Korean community-dwelling older men and women?","authors":"Sohee Kim ,&nbsp;Hyung Eun Shin ,&nbsp;Miji Kim ,&nbsp;Chang Won Won","doi":"10.1016/j.archger.2025.105778","DOIUrl":"10.1016/j.archger.2025.105778","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the diagnostic accuracy of possible sarcopenia identification pathways, as suggested by Asian Working Group for Sarcopenia (AWGS) in 2019, by gender among Korean community-dwelling older adults.</div></div><div><h3>Design</h3><div>Cross-sectional analysis of data from 2,129 community-dwelling adults (70–84 years, 50.4% men) enrolled in Korean Frailty and Aging Cohort Study.</div></div><div><h3>Methods</h3><div>Based on AWGS 2019 guideline, possible sarcopenia was defined by low handgrip strength (HGS) or slow five-times chair stand test (5CST) time, referred to as “assessments.” “Case-findings” (low calf circumference [CC], SARC-F ≥4, or SARC-CalF ≥11) were recommended for screening ‘possible sarcopenia’ before assessment. For the six ‘possible sarcopenia’ pathways (combining three case-finding and two assessment tools), area under the curve (AUC) and F₁ score are compared.</div></div><div><h3>Results</h3><div>For case-finding in men, CC demonstrated the highest AUC (0.657) and F₁ score (0.504) for predicting sarcopenia compared with SARC-F and SARC-CalF (<em>p</em> &lt;0.001, =0.001). Among men with low CC, ΔAUC between HGS and 5CST was not significant as assessment (<em>p</em>=0.079) (AUCs: 0.763 vs. 0.707; F₁ scores: 0.713 vs. 0.650). For case-finding in women, SARC-CalF demonstrated the highest AUC (0.631) and F₁ score (0.389) compared with CC and SARC-F (<em>p</em>=0.012, &lt;0.001). Subsequently, ΔAUC between HGS and 5CST was not significant in women (<em>p</em>=0.069) (AUCs: 0.566 vs. 0.636; F₁ scores: 0.387 vs. 0.514).</div></div><div><h3>Conclusions</h3><div>Based on AWGS 2019 guideline, CC in men and SARC-CalF in women was the best case-finding tool for community-dwelling older adults. After the best case-finding in each gender, two assessment pathways demonstrated insignificant difference in both genders.</div></div><div><h3>Brief summary</h3><div>For case-finding of possible sarcopenia, using calf circumference in older men and using SARC-CalF in older women demonstrated the highest diagnostic accuracy for predicting sarcopenia. After the best case-finding in each gender, two assessment pathways (handgrip strength and five-times chair stand test) of possible sarcopenia demonstrated insignificant difference in both genders.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105778"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dance interventions on cognitive function, balance, mobility, and life quality in older adults: A systematic review and Bayesian network meta-analysis","authors":"Hongli Zhang,&nbsp;Yilun Gao,&nbsp;Yuexin Zhang,&nbsp;Hongtao Ma","doi":"10.1016/j.archger.2025.105775","DOIUrl":"10.1016/j.archger.2025.105775","url":null,"abstract":"<div><h3>Background</h3><div>Physical inactivity in older adults is strongly associated with a variety of health problems that may lead to cognitive decline and impaired physical and mental health. The aim of this study was to investigate the effectiveness of five different dances on cognitive function and quality of life in older adults.</div></div><div><h3>Methods</h3><div>seven databases were systematically searched. Two reviewers independently completed the screening, quality assessment and data extraction of the study. Standardized mean differences (SMDs) were calculated using the Network package in Stata software and network meta-analyses (NMAs) were conducted using Bayesian consistency models using the GeMTC package in R software.</div></div><div><h3>Results</h3><div>The NMA consisted of 28 studies involving 1967 older adults aged 60 years or older, focusing on five different types of dance interventions. The results of the NMA showed that only ballroom dancing significantly improved cognitive function (SMD = 0.89, 95 % confidence interval [CI] (0.07, 1.70)), whereas tango and folk dancing significantly improved balance (SMD = 1. 62, 95 % CI (0.50, 2.76), (SMD = 1.43, 95 % CI (0.15, 2.81)), while tango and self-created dance enhanced mobility (SMD = -1.42, 95 % CI (-2.60, -0.25), (SMD = -1.20, 95 % CI (-2.10, -0.37)). Furthermore, square dancing was the only intervention that significantly improved mental health (SMD = 1.11, 95 % CI (0.03, 2.31)).</div></div><div><h3>Conclusion</h3><div>Ballroom dancing and square dancing appear to be the most effective interventions for improving cognitive ability and mental health, respectively, while tango shows promise as an intervention for improving balance and mobility.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105775"},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differing risk factors for potentially preventable and fall-related injury readmissions of older residents in long-term care facilities after hip fracture","authors":"Seigo Mitsutake ,&nbsp;Reidar P. Lystad ,&nbsp;Tolesa Okuba ,&nbsp;Janet C. Long ,&nbsp;Jeffrey Braithwaite ,&nbsp;Takumi Hirata ,&nbsp;Rebecca Mitchell","doi":"10.1016/j.archger.2025.105779","DOIUrl":"10.1016/j.archger.2025.105779","url":null,"abstract":"<div><h3>Background</h3><div>Although most fall-related injury readmissions are preventable, there may be differences between risk factors for other potentially preventable readmissions (PPR) and fall-related injury readmissions. This study examined the differences between risk factors for 30-day PPR and fall-related injury readmissions among older adults living in residential aged care facilities (RACFs) after a hip fracture.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used linked hospitalization and mortality data in New South Wales, Australia. Residents aged ≥65 years who live in RACFs and were admitted after a hip fracture between 2014 and 2023. Demographic data, the number of Charlson comorbidities, and frailty risk were used. The 30-day PPR was identified using 22 conditions as defined by the Australian government, and three additional conditions (pressure injury, dehydration, sepsis). Multivariable logistic regression examined the predictors for 30-day PPR and fall-related injury readmissions.</div></div><div><h3>Results</h3><div>Among 12,335 residents, there were 266 residents who experienced PPR, and 361 residents who experienced fall-related injury readmissions. Although residents with one (odds ratios: 1.98, 95 % confidence interval: 1.50–2.61) or ≥2 comorbidities (2.38, 1.67–3.37) had a higher risk of 30-day PPR than residents without comorbidities, there was no association of comorbidities with 30-day fall-related injury readmissions. Frailty risk was not associated with 30-day PPR, but residents with high (0.58, 0.37–0.92) and moderate frailty risk (0.63, 0.40–0.99) were less likely to experience fall-related injury readmissions than residents with no frailty risk.</div></div><div><h3>Conclusions</h3><div>Targeted approaches for 30-day PPR and fall-related injury readmissions should be optimized based on their specific predictors for preventing 30-day readmissions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105779"},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ikigai is associated with lower incidence of frailty during a 5-year follow-up in older women: The possible role of interleukin-6","authors":"Bo-Kyung Son ,&nbsp;Michiko Nanao-Hamai ,&nbsp;Yumi Umeda-Kameyama ,&nbsp;Weida Lyu ,&nbsp;Tomoki Tanaka ,&nbsp;Yasuyo Yoshizawa ,&nbsp;Masahiro Akishita ,&nbsp;Katsuya Iijima","doi":"10.1016/j.archger.2025.105776","DOIUrl":"10.1016/j.archger.2025.105776","url":null,"abstract":"<div><h3>Purpose</h3><div><em>Ikigai</em>, a psychological concept in Japanese culture representing a life worth living, contributes to health outcomes. This study examined the association between <em>Ikigai</em> and the incidence of frailty and sought to investigate the underlying biological mechanism by exploring inflammatory cytokines.</div></div><div><h3>Materials and methods</h3><div>In the 2016 Kashiwa Cohort Study, 832 community-dwelling older adults without frailty were enrolled. Participants reported their <em>Ikigai</em> status at baseline. Frailty was defined as meeting three of Fried's five phenotypic criteria. Plasma concentrations of inflammatory cytokines, including interleukins (ILs) and tumor necrosis factor α, were measured at baseline using immunoassays. Cox regression was used to analyze the association between <em>Ikigai</em> and new-onset frailty stratified by sex after adjusting for relevant confounders.</div></div><div><h3>Results</h3><div>Overall, 7.1 % of 832 participants (75.8 ± 4.7 years, women 47.0 %) developed new-onset frailty during the 5-year follow-up. Older adults with <em>Ikigai</em> (<em>n</em> = 749) had better vitality and mental health and fewer depressive symptoms than those without <em>Ikigai</em>. In women, <em>Ikigai</em> was associated with a lower risk of developing frailty (a fully-adjusted hazard ratio=0.24, 95 % confidence interval: 0.08–0.73, <em>P</em> = 0.012). Notably, a significantly lower prevalence of exhaustion was observed in women with <em>Ikigai</em> (<em>P</em> &lt; 0.001). A higher concentration of IL-6 was observed in women with <em>Ikigai</em> at baseline than in those without <em>Ikigai</em> who developed frailty (<em>P</em> = 0.036).</div></div><div><h3>Conclusions</h3><div>This study demonstrated that <em>Ikigai</em> could prevent frailty in women, which might be attributed to mitigate exhaustion. Furthermore, the biological actions of <em>Ikigai</em> are associated with high IL-6 levels. Our findings suggest that sex-specific frailty prevention should be considered with <em>Ikigai</em>.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105776"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143355441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear ageing gero-marker dynamics of transcriptomic profile during calcific aortic valve mouse modeling","authors":"Hongzheng Li ,&nbsp;Xiaoshan Cui ,&nbsp;Zucheng Shang ,&nbsp;Wenwen Yang ,&nbsp;Aimei Lu ,&nbsp;Hao Guo ,&nbsp;Zhi'ang Cheng ,&nbsp;Jiayan Zhou ,&nbsp;Yue Wei ,&nbsp;Mengfan Li ,&nbsp;Guang Chen ,&nbsp;Zikai Yu","doi":"10.1016/j.archger.2025.105777","DOIUrl":"10.1016/j.archger.2025.105777","url":null,"abstract":"<div><div>The prevention and management of degenerative heart disease remain challenging and could potentially be significantly improved by understanding of ageing biomarker dynamics. In this study, we constructed the calcific aortic valve mouse model at different age points, measured valve function degeneration along with valve calcification, and investigated the nonlinear dynamics using sequencing data and deep learning models. In C57BL/6 N mouse model, the older mice had higher levels of peak transvalvular jet velocity in terms of valve function. Regarding valve calcification, collagen and elastic fiber calcification in the middle layer increased significantly at 48-week-old (<em>p</em> &lt; 0.001), and the calcification spread to the inner endothelial cells at 72-week-old (<em>p</em> &lt; 0.0001). RNA sequencing illustrated that 30 genes, including <em>Acadsb, L2hgdh</em>, and <em>Cpped1</em>, showed increased expression with age. Among them, four genes, namely <em>Hipk2, 9430069I07Rik, Peli3</em>, and <em>Slc22a12</em>, increased more than threefold in aortic tissues in 72-week-old mice compared to 6-week-old mice. Moreover, a large proportion of genes changed in a nonlinear pattern (6,325 out of 12,160, 52%). In conclusion, both linear and nonlinear gero-markers were found in the calcific aortic valve mouse modeling, which highlighted specific periods of significant wave with accelerated ageing (48-week-old in mice).</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105777"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between trajectories of intrinsic capacity and differences in the risk of functional ability decline in community-dwelling older adults: A socio-ecological approach","authors":"Ji Hye Shin ,&nbsp;Hae Sagong ,&nbsp;Ju Young Yoon","doi":"10.1016/j.archger.2025.105772","DOIUrl":"10.1016/j.archger.2025.105772","url":null,"abstract":"<div><h3>Background</h3><div>Functional ability (FA), a key determinant of healthy aging, is determined by intrinsic capacity (IC), environmental factors, and their interactions. IC is a composite of physical and mental capacities that undergo constant change. Therefore, understanding the factors that influence IC requires a multi-level analysis of individuals to optimize its trajectory.</div></div><div><h3>Methods</h3><div>Individuals aged ≥ 65 were included in the Korean Longitudinal Study of Aging (2012–2020). Impaired IC (IIC) scores were tracked over eight years using latent class growth modeling to classify trajectory patterns. Determinants were identified through multinomial logistic regression. The relationship between IIC trajectory and FA decline was assessed using Kaplan-Meier analysis and the Cox proportional hazards model.</div></div><div><h3>Results</h3><div>Of the 7486 subjects, 2268 (mean age 72.26 [SD 5.31] years; female 56.4 %) were included after excluding those who were underage, had lost independence, or were missing baseline data. The IIC trajectories were categorized into four classes: low-persistent (Class 1, 48.46 %); low-increasing (Class 2, 17.46 %); high-decreasing (Class 3, 20.37 %); and high-stable (Class 4, 13.71 %). Over a mean follow-up of 7.21 years, 536 individuals experienced a decline in FA. After adjusting for confounders, the hazard ratios (HRs) were 1.95 (95 % CI 1.51–2.50) for class 2, 1.93 (1.50–2.46) for class 3, and 3.41 (2.64–4.39) for class 4 compared to class 1. Additionally, age, gender, marital status, employment, social participation, and living status had overlapping effects on both IC and FA.</div></div><div><h3>Conclusions</h3><div>Understanding the heterogeneity of IC, combined with multidomain interventions, can enable FA maintenance and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105772"},"PeriodicalIF":3.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between adverse childhood experiences and subjective cognitive decline: A scoping review","authors":"Areum Kim ,&nbsp;Byunghoon “Tony” Ahn ,&nbsp;Yeonjin Kim ,&nbsp;Jae Won Oh ,&nbsp;Jaesub Park ,&nbsp;Han Wool Jung ,&nbsp;Woo Jung Kim","doi":"10.1016/j.archger.2025.105773","DOIUrl":"10.1016/j.archger.2025.105773","url":null,"abstract":"<div><h3>Background</h3><div>Long-term health effects of adverse childhood experiences (ACEs) include cognitive decline that occurs later in life. Subjective cognitive decline (SCD), recognized as an early indicator of Alzheimer's disease, may present an essential period for intervention in populations with ACEs.</div></div><div><h3>Objective</h3><div>This review aims to explore the associations between ACEs and SCD, while examining the potential moderating effects of sociodemographic factors</div></div><div><h3>Methods</h3><div>A systematic search of four databases (Medline, PsycINFO, CINAHL, and Web of Science) was conducted from inception to July 2024. Eligible studies included adults with a history of ACEs and self-reported SCD. In total, twelve studies were included, primarily using U.S.-based samples, with sample sizes ranging from 46 to over 195,000 participants.</div></div><div><h3>Results</h3><div>The evidence of a dose-response relationship highlights the link between ACEs and SCD. The risk of SCD increases among adults over 65, lower-income groups, and sexual minorities. However, gender differences were inconsistently observed across studies. Mental health conditions, particularly depression is a significant risk factor.</div></div><div><h3>Conclusions</h3><div>Early screening and intervention for SCD among individuals with high ACE exposure may help delay the progression to severe cognitive impairment. However, the reliance on cross-sectional studies and high risk of bias limit causal inferences. Future research should explore longitudinal studies with diverse populations to clarify causal pathways and the role of sociodemographic factors in the ACE-SCD relationship.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105773"},"PeriodicalIF":3.5,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143311244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between functional social support, marital status and memory in middle-aged and older adults: An analysis of the canadian longitudinal study on aging","authors":"Paniz Haghighi ,&nbsp;Leilei Zeng ,&nbsp;Suzanne L. Tyas ,&nbsp;Samantha B. Meyer ,&nbsp;Mark Oremus","doi":"10.1016/j.archger.2025.105770","DOIUrl":"10.1016/j.archger.2025.105770","url":null,"abstract":"<div><h3>Purpose</h3><div>Although several studies have reported positive associations between functional social support (FSS) and memory, few have explored how other social variables, such as marital status, may affect the magnitude and direction of this association. We examined whether marital status modifies the association between FSS and memory in a sample of community-dwelling, middle-aged and older adults.</div></div><div><h3>Methods</h3><div>Data at three timepoints, spanning six years, were analyzed from the Tracking Cohort of the Canadian Longitudinal Study on Aging (n = 10,318). Linear mixed models were used to regress memory onto FSS across all three timepoints, adjusting for multiple covariates. The moderating effect of marital status was assessed by adding its interaction with FSS in the model. Separate regression models were built for overall FSS and four subtypes (positive interactions, affectionate, emotional/informational, and tangible support).</div></div><div><h3>Results</h3><div>We found significant and positive adjusted associations for overall FSS (β: 0.07; 95 % CI: 0.01, 0.13), positive interactions (β: 0.06; 95 % CI: 0.01, 0.11), and affectionate support (β: 0.05; 95 % CI: 0.00, 0.11) with memory. However, the interaction between marital status and FSS (overall and subtypes) was not statistically significant (likelihood ratio test p-value = 0.75), indicating that FSS does not have differing effects on memory depending on marital status.</div></div><div><h3>Conclusion</h3><div>Our findings do not provide evidence to suggest that marital status affects the association between FSS and memory in middle-aged and older adults. Nonetheless, policymakers and practitioners should take a comprehensive approach when exploring how various dimensions of social relationships may uniquely influence cognitive trajectories.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105770"},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythm gene cryptochrome 2 (Cry2) interacts with lipid metabolism to promote vascular aging","authors":"Yu Xiao ,&nbsp;Yang Li ,&nbsp;Jinning Gu ,&nbsp;Shan Lu ,&nbsp;Shuang Yu ,&nbsp;Chunli Song","doi":"10.1016/j.archger.2025.105761","DOIUrl":"10.1016/j.archger.2025.105761","url":null,"abstract":"<div><h3>Background</h3><div>Vascular aging is the basis of many chronic diseases of the aged, such as hypertension, coronary heart disease and stroke.</div></div><div><h3>Objective</h3><div>This study aims to deepen our understanding of the pathological mechanisms of vascular aging by combining multiple big data research methods, and reveal potential therapeutic targets and biomarkers.</div></div><div><h3>Methods</h3><div>WGCNA method was used to integrate the aortic transcriptome data of multiple age stages, and extract the key module and key pathway. The gene of aortic rhythm was integrated by JTK algorithm. Correlation calculation was performed for core gene and associated pathways. Finally, the expression of the core gene and their interaction with the associated pathways were verified in cell senescence.</div></div><div><h3>Results</h3><div>WGCNA showed that circadian rhythm is the key pathway of vascular aging, and circadian rhythm and metabolism interact to promote the occurrence of vascular aging. <em>Cry2</em> has been identified as the most critical core rhythm gene. Lipid metabolism is the most <em>Cry2</em>-related subpathway, among which phospholipid metabolism and <em>Serac1</em> have the strongest and most significant correlation with <em>Cry2. Cry2</em> is mainly distributed in endothelial cells in both young and senescent blood vessels, and affects five lipid-related metabolic processes including lipid transport during endothelial senescence.</div></div><div><h3>Conclusion</h3><div>This study suggests that circadian rhythm and <em>Cry2</em> may be potential targets of vascular aging, and further studies on their interaction with lipid metabolism will provide effective strategies for the prevention and treatment of age-related vascular diseases.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105761"},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}