Archives of gerontology and geriatrics最新文献

{"title":"Prevalence and prognostic significance of cachexia diagnosed by novel definition for Asian population among Chinese cirrhotic patients","authors":"Shuangzhe Yao ,&nbsp;Ziyi Yang ,&nbsp;Jia Li ,&nbsp;Binbin Peng ,&nbsp;Han Wang ,&nbsp;Jing Liang ,&nbsp;Chao Sun","doi":"10.1016/j.archger.2025.105833","DOIUrl":"10.1016/j.archger.2025.105833","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Cachexia is a multifaceted metabolic disorder often linked to chronic illnesses, characterized by substantial weight reduction, inflammatory states, and loss of appetite. The novel diagnostic criteria concerning cachexia established by the Asian Working Group for Cachexia (AWGC) have not been fully validated in Chinese populations with cirrhosis. To assess the prognostic impact of AWGC-defined cachexia among hospitalized cirrhotic patients and explore the synergistic impact of Model for End-Stage Liver Disease 3.0 (MELD 3.0) scores with cachexia status on prognosis.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed clinical data from patients with decompensated cirrhosis admitted to our tertiary hospital between January 2021 and December 2023. Cachexia was identified according to AWGC criteria, and disease severity was assessed using MELD 3.0 scores. The study's primary outcome was all-cause mortality within one year.</div></div><div><h3>Results</h3><div>A total of 368 patients were included in the analyses. The prevalence of cachexia was 61.7 %, and patients with cachexia had a significantly higher one-year all-cause mortality rate (26.4 % vs. 7.8 %, <em>P</em> &lt; 0.001). Multivariate Cox regression analysis showed that cachexia (HR 2.68, 95 %CI 1.40–5.13, <em>P</em> = 0.003), along with MELD 3.0 (HR 1.18, 95 %CI 1.13–1.23, <em>P</em> &lt; 0.001), were independent predictors of one-year mortality. The combined assessment of cachexia and MELD 3.0 scores yielded a higher discriminative ability for predicting one-year mortality compared to either metric alone.</div></div><div><h3>Conclusions</h3><div>AWGC-defined cachexia is a significant prognostic factor in hospitalized patients with cirrhosis. The integration of cachexia with MELD 3.0 scoring enhances prognostic prediction, underscoring the importance to introduce cachexia evaluation during clinical practice for this vulnerable setting.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105833"},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neighborhood physical environment with falls and fear of falling in older adults: A prospective cohort study","authors":"Lucía Arias-Fernández ,&nbsp;Lucía Carcedo-Argüelles ,&nbsp;Esther García-Esquinas ,&nbsp;Francisco Félix Caballero ,&nbsp;Fernando Rodríguez-Artalejo ,&nbsp;Alberto Lana","doi":"10.1016/j.archger.2025.105831","DOIUrl":"10.1016/j.archger.2025.105831","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore the prospective association between physical environment characteristics of the neighborhood and risk of falls/fear of falling among community-dwelling older adults.</div></div><div><h3>Study Design</h3><div>Prospective cohort analysis using data from the Seniors-ENRICA-2 cohort (metropolitan Madrid, Spain).</div></div><div><h3>Methods</h3><div>At baseline (2015–17), a neighborhood physical characteristics score was developed using the Physical Activity Neighborhood Environment Scale and an additional indicator of distance to green areas. In the second wave of follow-up (2019–20) we collected self-reported incident falls and fear of falling, assessed with the Short Falls Efficacy Scale International. Adjusted odds ratios (OR) and 95 % confidence intervals (CI) for the association between neighborhood environment perception and incidence of falls/fear of falling were calculated using logistic regression.</div></div><div><h3>Results</h3><div>Among 1823 participants, 27.7 % reported a fall during the previous year and 32.1 % were concerned about having a fall. Better neighborhood environment was associated with lower risk of falls (OR: 0.75; 95 %CI: 0.57–0.99) and fear of falling (0.73; 0.55–0.96). Specifically, low traffic intensity (0.68; 0.52–0.90) and sidewalks in good condition (0.75; 0.59–0.95) were associated with lower risk of falling. Moreover, available facilities for biking (0.77; 0.61–0.96), sidewalks in good condition (0.67; 0.52–0.86), night security (0.80; 0.60–0.99) and day security (0.62; 0.44–0.98) were independently associated with lower fear of falling.</div></div><div><h3>Conclusions</h3><div>Better neighborhood physical environments could play a key role in the prevention of falls and fear of falling among older adults. Policies aiming to improve residential environments can have broad implications for achieving healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105831"},"PeriodicalIF":3.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life-course socioeconomic inequalities, social mobility and healthy aging in older adults: A multi-cohort study","authors":"Ziting Huang ,&nbsp;Eric T.C. Lai ,&nbsp;Hideki Hashimoto ,&nbsp;Michael Marmot ,&nbsp;Jean Woo","doi":"10.1016/j.archger.2025.105829","DOIUrl":"10.1016/j.archger.2025.105829","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate how socioeconomic positions at different life stages, their relative importance, and social mobility influence IC across the USA, UK, Europe, China, and Japan among adults aged ≥50 years.</div></div><div><h3>Methods</h3><div>We included 54,217 participants from five nationally representative cohorts in the USA, UK, Europe, China, and Japan. Life-course socioeconomic positions were assessed in early-life (childhood socioeconomic positions), early-adulthood (education), and late-adulthood (household wealth). Healthy aging was measured by intrinsic capacity including cognition, psychological health, locomotion, vitality, and sensory functions. Linear mixed models were used to estimate the associations of intrinsic capacity with each socioeconomic position indicator and social mobility.</div></div><div><h3>Findings</h3><div>Higher levels of education and wealth were both significantly associated with better intrinsic capacity (<em>p</em> &lt; 0.05 in all cohorts).</div><div>Education had a stronger impact on intrinsic capacity than wealth in the USA, Europe, China, and Japan. Middle and high childhood socioeconomic positions were significantly linked to better intrinsic capacity compared with the low group (<em>p</em> &lt; 0.05 in all cohorts). Compared to stable groups, upward and downward social mobility groups were associated with better and worse intrinsic capacity, respectively.</div></div><div><h3>Conclusion</h3><div>Socioeconomic measures throughout the life course can predict healthy aging in the USA, Europe, and Asia. The long-term negative impact of disadvantaged childhood socioeconomic positions on healthy aging can be partially mitigated by upward mobility later in life. Policies need to narrow the social inequalities from early life and prevent adults from experiencing downward mobility, thereby reducing disparities in healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105829"},"PeriodicalIF":3.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burdens of hip fractures in elderly individuals from 1990 to 2021 and predictions up to 2050: A systematic analysis of the Global Burden of Disease Study 2021","authors":"Chuwei Tian ,&nbsp;Liu Shi ,&nbsp;Jinyu Wang ,&nbsp;Jun Zhou ,&nbsp;Chen Rui ,&nbsp;Yueheng Yin ,&nbsp;Wei Du ,&nbsp;Shimin Chang ,&nbsp;Yunfeng Rui","doi":"10.1016/j.archger.2025.105832","DOIUrl":"10.1016/j.archger.2025.105832","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to analyse the global, regional, and national burdens of hip fractures in older adults from 1990 to 2021, with projections to 2050, on the basis of data from the GBD 2021 study.</div></div><div><h3>Methods</h3><div>We employed a joinpoint model to analyse trends in the burden of hip fractures from 1990‒2021. The estimated annual percentage change (EAPC) was used to quantify temporal trends over this period. We evaluated the relationship between the social development index and the burden of hip fracture in elderly people and conducted a health inequality analysis. Additionally, we applied Long-short Term Memory (LSTM) networks to forecast burden trends of hip fractures up to 2050.</div></div><div><h3>Results</h3><div>The global age-standardized incidence rate (ASIR) for hip fractures in older adults rose from 781.56 per 100,000 in 1990 to 948.81 in 2021. The 2021 age-standardized prevalence rate (ASPR) was 1,894.07, and the age-standardized YLD rate (ASDR) was 173.52. From 1990 to 2021, the incidence and prevalence increased by 168.71 % and 173.07 %, respectively, while the burden of DALYs decreased. Future trends were projected via the LSTM. The burden and risk factors for hip fractures varied significantly by sex, country, and region. Population and aging are primary contributors to the rising incidence of elderly hip fractures, with falls being the leading direct cause.</div></div><div><h3>Conclusion</h3><div>From 1990 to 2021, the global burden of hip fractures in the elderly population, especially among older women, steadily increased. Population ageing highlights the urgent need for targeted public health interventions and resource allocation, including early diagnosis, effective prevention strategies, and region-specific management approaches.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105832"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Age Gap Associations with Body Composition and Metabolic Indices in an Asian Cohort: An MRI-Based Study","authors":"Han-Jui Lee ,&nbsp;Chen-Yuan Kuo ,&nbsp;Yu-Chung Tsao ,&nbsp;Pei-Lin Lee ,&nbsp;Kun-Hsien Chou ,&nbsp;Chung-Jung Lin ,&nbsp;Ching-Po Lin","doi":"10.1016/j.archger.2025.105830","DOIUrl":"10.1016/j.archger.2025.105830","url":null,"abstract":"<div><h3>Background</h3><div>Global aging raises concerns about cognitive health, metabolic disorders, and sarcopenia. Prevention of reversible decline and diseases in middle-aged individuals is essential for promoting healthy aging. We hypothesize that changes in body composition, specifically muscle mass and visceral fat, and metabolic indices are associated with accelerated brain aging. To explore these relationships, we employed a brain age model to investigate the links between the brain age gap (BAG), body composition, and metabolic markers.</div></div><div><h3>Methods</h3><div>Using T1-weighted anatomical brain MRIs, we developed a machine learning model to predict brain age from gray matter features, trained on 2,675 healthy individuals aged 18–92 years. This model was then applied to a separate cohort of 458 Taiwanese adults (57.8 years ± 11.6; 280 men) to assess associations between BAG, body composition quantified by MRI, and metabolic markers.</div></div><div><h3>Results</h3><div>Our model demonstrated reliable generalizability for predicting individual age in the clinical dataset (MAE = 6.11 years, <em>r</em> = 0.900). Key findings included significant correlations between larger BAG and reduced total abdominal muscle area (<em>r</em> = -0.146, <em>p</em> = 0.018), lower BMI-adjusted skeletal muscle indices, (<em>r</em> = -0.134, <em>p</em> = 0.030), increased systemic inflammation, as indicated by high-sensitivity C-reactive protein levels (<em>r</em> = 0.121, <em>p</em> = 0.048), and elevated fasting glucose levels (<em>r</em> = 0.149, <em>p</em> = 0.020).</div></div><div><h3>Conclusions</h3><div>Our findings confirm that muscle mass and metabolic health decline are associated with accelerated brain aging. Interventions to improve muscle health and metabolic control may mitigate adverse effects of brain aging, supporting healthier aging trajectories.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105830"},"PeriodicalIF":3.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From patterns to pathways: Latent class trajectories of self-perceptions of aging and their causal effects on multi-state functional transitions","authors":"Lingjun Liu ,&nbsp;Boshu Mao ,&nbsp;Fei Ji","doi":"10.1016/j.archger.2025.105827","DOIUrl":"10.1016/j.archger.2025.105827","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the heterogeneous developmental trajectories of self-perceptions of aging (SPA) and their causal effects on functional health transitions in older adults. Specifically, we aim to identify latent classes of SPA development, assess their impact on multi-state functional transitions, and quantify the loss in healthy life expectancy attributable to negative SPA.</div></div><div><h3>Methods</h3><div>Drawing from the Chinese Longitudinal Healthy Longevity Survey (2008–2018; <em>n</em> = 14,020), we implemented latent class trajectory modeling to identify SPA developmental patterns. We then applied multi-state Markov models to examine the effects of SPA on transitions among functional states (fully independent, assistance needed, and deceased), and established a counterfactual framework to estimate the loss in multi-state life expectancy attributable to SPA.</div></div><div><h3>Results</h3><div>Analysis revealed two distinct SPA trajectories: a high-level group (57.75 %) and a low-level group (42.25 %), both exhibiting declining trends while maintaining consistent level differences. After adjusting for demographic characteristics, negative SPA significantly increased the risk of functional impairment (HR=1.31, 95 % CI: 1.20–1.44) and diminished the probability of functional recovery (HR=0.61, 95 % CI: 0.53–0.71). At age 65, negative SPA was associated with a 2.18-year reduction in total life expectancy, with substantial disparities in healthy life expectancy (10.93 vs. 7.96 years).</div></div><div><h3>Discussion</h3><div>This study reveals two distinct trajectories of SPA in later life and demonstrates its causal effects on health state transitions. Early interventions targeting negative aging perceptions, particularly before age 65, may effectively extend healthy life expectancy.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105827"},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical frailty and social support in community-dwelling older adults: A systematic review","authors":"Xiaofan Dou ,&nbsp;Lifeng Yao ,&nbsp;Hai Xu ,&nbsp;Ruijian Yan ,&nbsp;Nannan Dai ,&nbsp;Qiao He","doi":"10.1016/j.archger.2025.105826","DOIUrl":"10.1016/j.archger.2025.105826","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults with frailty have an increased likelihood of unmet care needs, falls and fractures and so on, which brings serious burdens to society. By evaluating the association between physical frailty and social support in community-dwelling older adults, we will provide reference for preventing the occurrence of frailty.</div></div><div><h3>Methods</h3><div>Cross-sectional and longitudinal studies on association between frailty and social support in community-dwelling older adults were mainly searched from the database of Medline, Embase, PsycINFO, CINAHL Plus and Web of Science from their establishment to February 16, 2024. After literature screening, two researchers completed data extraction, and the risk of bias was assessed using the 8-item Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies for cross-sectional studies and the Newcastle-Ottawa Scale for Cohort Studies for longitudinal studies.</div></div><div><h3>Results</h3><div>The study included a total of 14 articles, including 9 cross-sectional studies and 5 longitudinal studies. There was no clear consensus on the correlation between social support and frailty among community-dwelling older adults. The overall quality of the included studies was very high.</div></div><div><h3>Conclusion</h3><div>Although the correlation between social support and frailty among community-dwelling older adults needs further verification, given the important role of social support, it is still recommended that family members provide multi-faceted social support, especially subjective support, for older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105826"},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of group reminiscence therapy assisted by memory specificity training (GRT-mest) on depressive symptoms in older adults: A cluster randomized controlled trial","authors":"Yuejin Wu ,&nbsp;Tianzhuo Yu ,&nbsp;Yuanjian Xia ,&nbsp;Yuewei Li ,&nbsp;Lirong Guo ,&nbsp;Xin Leng ,&nbsp;Ting Zeng ,&nbsp;Xinyang Bai ,&nbsp;Lijuan Zhang ,&nbsp;Xuejiao Wu ,&nbsp;Haiyan Xu ,&nbsp;Yanwei Du ,&nbsp;Feng Li","doi":"10.1016/j.archger.2025.105811","DOIUrl":"10.1016/j.archger.2025.105811","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the effects of the Group Reminiscence Therapy assisted by Memory Specificity Training (GRT-mest) in older adults, and to further investigate the indirect effect of autobiographical memory in improving depressive symptoms.</div></div><div><h3>Methods</h3><div>In this single-blind, three-arm parallel group, cluster randomized controlled trial, 78 eligible participants were randomly assigned to two intervention groups and one control group in two nursing homes, and assessments were conducted at baseline, immediately post-intervention, and 1-month and 3-month follow-ups. Data analysis was performed using SPSS 26.0.</div></div><div><h3>Results</h3><div>The GRT-mest had more significant improvements in depressive symptoms (ES=0.08, <em>P</em> &lt; 0.001), autobiographical memory (ES=0.07, <em>P</em> &lt; 0.001), and rumination (ES=0.07, <em>P</em> &lt; 0.001) compared to other two groups, and these effects were maintained up to 3 months post-intervention. The improvement of autobiographical memory only had an indirect effect on improving depressive symptoms at immediately post-intervention (Indirect effect =-1.3231, 95% CI [-2.4187, -0.4053], <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The GRT-mest can improve depressive symptoms, autobiographical memory, and rumination in older adults, with these effects being maintained for up to 3 months. Additionally, the improvement in autobiographical memory plays a short-term mediating role in alleviating depressive symptoms. This study further supports the theoretical effectiveness of incorporating mest into the treatment of depressive symptoms among older adults in domestic settings.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105811"},"PeriodicalIF":3.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning model for predicting depression in middle-aged and elderly Chinese arthritis patients: A nationwide prospective cohort study","authors":"Xiao Xu ,&nbsp;Hai-Yan Huang ,&nbsp;Shu-yun Wang ,&nbsp;Shen-Yee Tan ,&nbsp;Hong-Hui Chen ,&nbsp;Ming-Ming Zhou ,&nbsp;Mei-juan Qian","doi":"10.1016/j.archger.2025.105810","DOIUrl":"10.1016/j.archger.2025.105810","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"134 ","pages":"Article 105810"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FP receptor inhibits autophagy to aggravate aging-related cardiac fibrosis through PI3K/AKT/mTOR signaling pathway","authors":"Jia Qi ,&nbsp;Bin Lu ,&nbsp;Cheng-wei Jin ,&nbsp;Yuan-yuan Shang ,&nbsp;Hui Pan ,&nbsp;Hao Li ,&nbsp;Zhou-jie Tong ,&nbsp;Wei Zhang ,&nbsp;Lu Han ,&nbsp;Ming Zhong","doi":"10.1016/j.archger.2025.105824","DOIUrl":"10.1016/j.archger.2025.105824","url":null,"abstract":"<div><h3>Background</h3><div>F-prostanoid receptor (FP receptor), a receptor for Prostaglandin F2α(PGF2α), is involved in the process of tissue fibrosis, but its exact role in the aging heart remains unclear.</div></div><div><h3>Methods</h3><div>We investigated cardiac function, myocardial fibrosis levels, autophagy levels and related mechanistic pathways in different groups of mice using gene silencing. At the cellular level, we simulated the senescence process of cardiac fibroblasts and investigated the related mechanisms using relevant inhibitors.</div></div><div><h3>Results</h3><div>In aging mice, FP receptor and PI3K/AKT/mTOR pathways are increased and autophagy levels are decreased, ultimately leading to cardiac fibrosis. FP receptor gene silencing slows down the above process. We found similar changes at the cellular level.</div></div><div><h3>Conclusion</h3><div>FP receptor could activate PI3K/AKT/mTOR pathway and inhibit cardiac autophagy, which resulted in aging-related cardiac fibrosis. Thus, the inhibition of FP receptor could improve aging-related cardiac remodeling, implicating its potential therapeutic application to treat cardiovascular diseases associated with aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105824"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}