Cumulative blood pressure burden and the risk of functional dependence in elderly cohorts: An exploration of the influencing factors

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-03-31 DOI:10.1016/j.archger.2025.105849

Yanfen Hu , Junxia Yu , Zhenjie Xu , Lingxia Li

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引用次数: 0

Abstract

Background

To investigate the correlation between cumulative blood pressure levels and functional dependence in individuals aged 60 and older.

Methods

Data were sourced from two distinct elderly databases: CHARLS and ELSA. Various statistical techniques, including logistic regression analysis, restricted cubic spline analysis, forest plot visualization, and interaction analyses, were employed to delve into the associations between cumulative blood pressure and difficulties in performing activities of daily living.

Results

Across both cohorts, there was a discernible trend towards an increased risk of ADL difficulties with escalating cumulative blood pressure levels. Logistic regression analysis confirmed a statistically significant relationship between cumulative blood pressure and ADL difficulties (P < 0.001). The results derived from restricted cubic spline plots further underscored this relationship, demonstrating that, after adjusting for a multitude of confounding factors, the risk of ADL difficulties augmented with rising cumulative blood pressure. Additionally, the forest plot and interaction plot findings revealed that the association between heightened cumulative blood pressure and the risk of ADL difficulties was contingent upon factors such as body mass index, gender, and memory-related disorders.

Conclusions

Our findings indicate a positive correlation between cumulative blood pressure and the risk of experiencing difficulties with ADLs. Furthermore, this association appears to be modulated by BMI, gender, and the presence of memory-related diseases.

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老年人群累积血压负担与功能依赖风险的影响因素探讨

背景研究 60 岁及以上老年人的累积血压水平与功能依赖性之间的相关性：数据来自两个不同的老年人数据库：CHARLS 和 ELSA。采用多种统计技术，包括逻辑回归分析、限制性三次样条分析、森林图可视化和交互分析，深入研究累积血压与日常生活活动困难之间的关系。逻辑回归分析证实，累积血压与日常活动障碍之间存在显著的统计学关系（P < 0.001）。限制性三次样条曲线图得出的结果进一步强调了这种关系，表明在对多种混杂因素进行调整后，ADL 困难的风险随着累积血压的升高而增加。此外，森林图和交互图结果显示，累积血压升高与 ADL 困难风险之间的关系取决于体重指数、性别和记忆相关疾病等因素。此外，这种关联似乎受到体重指数、性别和记忆相关疾病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.