Archives of gerontology and geriatrics最新文献

{"title":"Age-related changes in anthropometric measurements, body composition, and physical function among middle-aged and older Japanese community-dwellers: A longitudinal study","authors":"Rei Otsuka ,&nbsp;Shu Zhang ,&nbsp;Yukiko Nishita ,&nbsp;Sayaka Kubota ,&nbsp;Chikako Tange ,&nbsp;Hiroshi Shimokata ,&nbsp;Hiroshi Yatsuya","doi":"10.1016/j.archger.2025.105943","DOIUrl":"10.1016/j.archger.2025.105943","url":null,"abstract":"<div><h3>Objective</h3><div>To quantify annual changes and develop population-normalized aging curves for height, body weight, and grip strength according to specific birth cohorts.</div></div><div><h3>Methods</h3><div>This longitudinal study analyzed data from the National Institute for Longevity Sciences – Longitudinal Study of Aging, following 1901 community-dwelling adults aged 40−79 years for up to 12 years. Annual changes in height, body weight, body mass index (BMI), body fat percentage, skeletal muscle mass, and grip strength were assessed by sex using linear mixed-effects models. Birth cohort-specific reference values according to sex were developed using participants who participated in at least one wave between 1997 and 2022 (<em>n</em> = 1990) with generalized additive mixed models.</div></div><div><h3>Results</h3><div>Significant negative follow-up years × age interactions were observed for height, body weight, BMI, skeletal muscle mass, and grip strength in men (all <em>p</em>-values &lt; 0.001) and for height, body weight, BMI, body fat percentage, and skeletal muscle mass in women (all <em>p</em>-values &lt; 0.01). Grip strength began declining preceding any significant change in other indicators. For height and grip strength, birth cohort-specific reference values for age-related changes showed a gradual decline with age in both sexes, with more recent birth cohorts being consistently taller but having weaker grip strength than earlier cohorts. Men experienced slight weight increases until ages 60−70 years, followed by a decline. Women maintained a stable weight until age 60 years before declining.</div></div><div><h3>Conclusions</h3><div>These reference values provide evidence-based tools for detecting age-related changes in body composition and function among relatively healthy participants and guiding preventive interventions in clinical and community settings.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105943"},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health clusters and risk of cardiovascular disease among community-dwelling older men and women: A clustering and causal machine learning approach","authors":"Achamyeleh Birhanu Teshale ,&nbsp;Htet Lin Htun ,&nbsp;Alice J. Owen ,&nbsp;Mor Vered ,&nbsp;Christopher M. Reid ,&nbsp;Andrew Tonkin ,&nbsp;Rosanne Freak-Poli","doi":"10.1016/j.archger.2025.105942","DOIUrl":"10.1016/j.archger.2025.105942","url":null,"abstract":"<div><h3>Background</h3><div>Social determinants of health (SDoH) significantly impact cardiovascular disease (CVD) risk. This study aims to identify SDoH clusters and explore their cumulative effects on CVD risk.</div></div><div><h3>Methods</h3><div>Data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, ASPREE eXTension study, and ASPREE Longitudinal Study of Older Persons (ALSOP) were used. The study participants were community-dwelling healthy individuals (5884 men and 7012 women) aged 70+ years. These participants were followed for 12 years (median: 8.4 years). The K-prototype algorithm to identify clusters of SDoH and the Cox model to evaluate the association between the SDoH clusters and CVD events were used. Causal Survival Forest was employed to explore the heterogenous treatment effect (HTE) of the SDoH clusters on CVD events.</div></div><div><h3>Results</h3><div>Two SDoH clusters, disadvantageous and advantageous, were identified. The advantageous group were more economically stable, socially active, and had positive neighbourhood factors. Being membership in the advantageous group was statistically significantly associated with a 31 % reduced risk of CVD events among women. By taking the disadvantageous SDoH group as the <em>control group</em> and the advantageous group as the <em>treated group</em>, there was indication of HTE on CVD among women; women who were in the treated group had delayed onset of CVD and the treatment could benefit specific groups, including smokers, individuals on antihypertensive medication, and older adults. However, among men there was no statistically significant association and HTE.</div></div><div><h3>Conclusion</h3><div>The study highlights the interconnectedness of SDoH and their greater impact on women's CVD risk compared to men.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105942"},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance training and blood pressure: Insights from a meta-analysis of the aging population","authors":"Negin Ghasemi Kahrizsangi ,&nbsp;Mohammad Ali Faridi Dastjerdi ,&nbsp;Faraz Golafshan ,&nbsp;Navidreza Ghasemi Kahrizsangi ,&nbsp;Mohammad Hossein Shafieyoun ,&nbsp;Mohammad Hadi Parsaeefar","doi":"10.1016/j.archger.2025.105941","DOIUrl":"10.1016/j.archger.2025.105941","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a prevalent cardiovascular risk factor in older adults, contributing to morbidity and mortality worldwide. While aerobic exercise is well-established for blood pressure (BP) management, the role of resistance training (RT) in aging populations remains less clear, with inconsistent findings across studies.</div></div><div><h3>Objective</h3><div>To evaluate the effect of RT on BP in adults aged 60 and older and explore moderators such as intervention duration, gender, and session frequency.</div></div><div><h3>Method</h3><div>Following PRISMA guidelines, we searched PubMed, Web of Science, Scopus, Cochrane Library, and Google Scholar for randomized controlled trials (RCTs) of RT (≥4 weeks) in older adults (mean age ≥60 years), published until February 2025. Data on systolic, diastolic, and mean BP were pooled using random-effects models, with subgroup and meta-regression analyses to assess heterogeneity sources.</div></div><div><h3>Results</h3><div>Fifty-one RCTs (<em>n</em> = 2025) demonstrated that RT significantly reduced systolic BP (MD = -6.11 mmHg), diastolic BP (MD = -2.53 mmHg), and mean BP (MD = -4.10 mmHg; all <em>p</em> &lt; 0.001). Subgroup analysis revealed larger systolic (females: -7.95 mmHg; males: -6.02 mmHg, NS) and diastolic BP reductions (females: -4.24 mmHg; males: -3.39 mmHg, NS), with mean BP reduced significantly in both sexes (females: -4.02 mmHg; males: -7.08 mmHg). Short-term (≤12 weeks) and higher frequency interventions enhanced BP reductions. Heterogeneity was high but sensitivity analyses confirmed robustness.</div></div><div><h3>Conclusion</h3><div>RT effectively lowers BP in older adults, supporting its inclusion in hypertension management strategies. Short-term, frequent RT protocols may optimize outcomes, particularly for females. Further research is needed to explore long-term effects and underlying mechanisms.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105941"},"PeriodicalIF":3.5,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health outcomes and healthcare utilization among older adults based on weight status and muscle strength: Insights from 27 European countries","authors":"Rafaela Cavalheiro do Espírito Santo,&nbsp;Geiziane Melo,&nbsp;Viney Prakash Dubey,&nbsp;Arturas Razbadauskas,&nbsp;Cesar Agostinis-Sobrinho","doi":"10.1016/j.archger.2025.105940","DOIUrl":"10.1016/j.archger.2025.105940","url":null,"abstract":"<div><h3>Background</h3><div>Overweight/obesity and low muscle strength negatively affect older adults’ health and are public health concerns. While previous studies link these conditions to poor outcomes, few have examined their combined association with healthcare use and chronic diseases. This study aims to assess these relationships.</div></div><div><h3>Methods</h3><div>A cross-sectional study using data from Wave 8 of the Survey of Health, Ageing and Retirement in Europe. Four groups were formed based on muscle strength(High vs Low)and weight status(Overweight/obesity vs Non-Overweight/obesity): Overweight/obesity and Low Muscle Strength (O/LM), Non- Overweight/obesity and Low Muscle Strength (NO/LM), Overweight/obesity and High Muscle Strength (O/HM), and Non- Overweight/obesity and High Muscle Strength (NO/HM).</div></div><div><h3>Results</h3><div>Among 53,217 participants(mean age 69.0), 56.9 % were women. Most participants were overweight or obese(63.0 %). Median muscle strength was 41.0 kg for men and 26.0 kg for women. Group distributions included 16.6 % in O/LM, 2.5 % in NO/LM, 53.4 % in O/HM, and 27.5 % in NO/HM. The O/LM group had a higher prevalence of long-term illnesses, multiple chronic diseases, and emergency hospitalizations. They were more likely to take five or more medications. In contrast, the NO/HM group showed better health, with fewer chronic conditions and lower medication use. The O/HM group had more public long-term care insurance. The O/LM group had higher probabilities of chronic diseases such as diabetes, stroke, and Alzheimer's, with risks decreasing across the groups.</div></div><div><h3>Conclusion</h3><div>Overweight/obesity with low muscle strength significantly increases healthcare utilization and the burden of chronic diseases in older adults, highlighting the need for targeted interventions for this vulnerable group.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105940"},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does life get better after middle age? Cultural comparisons of trends and key predictors of life satisfaction across the lifespan","authors":"Santi Sulandari ,&nbsp;Judith Johnson ,&nbsp;Rachel O Coats","doi":"10.1016/j.archger.2025.105939","DOIUrl":"10.1016/j.archger.2025.105939","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated 1) whether there are differences in the trajectory of life satisfaction (LS) across the lifespan between British and Indonesian adults, and 2) which factors are associated with LS overall, and according to culture and age.</div></div><div><h3>Methods</h3><div>1355 participants aged 18 to 91 were included: 649 British and 706 Indonesian. Participants completed an online questionnaire examining LS, quality of life (which included physical health, psychological wellbeing, social relationships, and environment), depression, anxiety, and religiosity. Data were examined looking at all participants within each culture and then by further separating each cultural group into three age groups (Young adults/YA (18-39), middle-aged/MA (40-59), older adults/OA (60+).</div></div><div><h3>Results</h3><div>The trajectory of LS across the lifespan was U-shaped in British participants but followed an inverted U-shaped pattern in Indonesian participants. Regression analyses on Indonesian and British participants (when all ages were grouped together) revealed that psychological well-being, social relationships, and environment were significantly associated with LS in both cultures, but LS was further impacted by other distinct factors in each group, such as anxiety and religiosity in Indonesian participants and depression in British participants. On analysing the age groups separately some of these predictors of LS were no longer significant, or were only applicable to specific age group(s) and/or one country.</div></div><div><h3>Discussion</h3><div>Psychological well-being, social relationships, and environment are important variables which should be incorporated into LS interventions for both cultures. Addressing the distinct needs of different cultures and age groups may further help when tailoring LS interventions for these different groups.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105939"},"PeriodicalIF":3.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pinch strength as an independent correlate of cognitive impairment beyond grip strength in older adults","authors":"Jing Ren ,&nbsp;Xiaoyan Chen ,&nbsp;Wenhua Jiang ,&nbsp;Qian Chen ,&nbsp;Ming Yang","doi":"10.1016/j.archger.2025.105938","DOIUrl":"10.1016/j.archger.2025.105938","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare pinch strength parameters against grip strength metrics for identifying cognitive impairment in community-dwelling older adults.</div></div><div><h3>Design</h3><div>Cross-sectional analysis of baseline data from a prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>954 community-dwelling older adults from three communities.</div></div><div><h3>Methods</h3><div>Pinch and grip strength were measured using portable dynamometers. Derived metrics included peak strength, coefficient of variation (CV), fatigue index, and pinch/grip ratio. Functional assessments were also collected. Cognitive impairment was defined by a Mini-Cog score ≤ 2. Multivariable logistic regression models, adjusted for age, sex, and education, assessed associations between standardized strength metrics and cognitive impairment, reporting adjusted odds ratios (ORs) and 95 % confidence intervals (CIs). Model performance was compared using Area Under the Receiver Operating Characteristic Curve (AUC), Decision Curve Analysis (DCA), and calibration.</div></div><div><h3>Results</h3><div>Cognitive impairment prevalence was 32.7 % (312/954). Lower peak pinch strength strongly correlated with cognitive impairment (OR 0.50, 95 % CI 0.40–0.61), remaining robust after adjusting for grip strength (OR 0.48, 95 % CI 0.38–0.60). Peak grip strength association attenuated when pinch was included. Higher grip strength CV also correlated with cognitive impairment (OR 1.2–1.3, <em>p</em> &lt; 0.05). A simple model with peak pinch strength (AUC 0.689) performed comparably to a full model (AUC 0.699, <em>p</em> = 0.121) and significantly better than a peak grip strength model (AUC 0.633, <em>p</em> &lt; 0.001). DCA indicated clinical utility for pinch-strength-based models.</div></div><div><h3>Conclusions</h3><div>Peak pinch strength demonstrated a stronger association with cognitive impairment than peak grip strength. This finding warrants further research into the mechanisms linking fine motor strength and cognition.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105938"},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidomain interventions for healthy aging: From neuroplasticity to population health","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105937","DOIUrl":"10.1016/j.archger.2025.105937","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105937"},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal relationship between intrinsic capacity, falls, and physical activity in Dutch older adults","authors":"Wesna Belimbegovski ,&nbsp;Laura A. Schaap ,&nbsp;Annemiek J. Linn ,&nbsp;Stephanie Medlock ,&nbsp;Julia C.M. van Weert ,&nbsp;Nathalie van der Velde ,&nbsp;Natasja M. van Schoor","doi":"10.1016/j.archger.2025.105936","DOIUrl":"10.1016/j.archger.2025.105936","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between intrinsic capacity (IC) and falls has not been studied in Western European older adults. This study aimed to examine the relationship between IC, falls, and physical activity (PA) in a Western European country, and to examine whether PA mediates the relation between IC and falls.</div></div><div><h3>Methods</h3><div>This study used data from community dwelling older adults from the Longitudinal Aging Study Amsterdam. Per participant, a baseline IC score was calculated (possible range 0–100). A Cox regression analysis (<em>n</em> = 1257) and a linear mixed model analysis (<em>n</em> = 1874) were used to examine the relation between IC and falls over a 3 year follow-up and between IC and PA over 3 and 6 years, respectively. A mediation analysis (<em>n</em> = 898) examined whether PA mediated the relation between IC and falls.</div></div><div><h3>Results</h3><div>Each one-point increase in IC score was associated with a 0.98 times lower 3-year fall hazard (95 % CI, 0.97–0.99). In older adults living in non-urban areas, those with the highest IC scores (range 71.7–92.5) spent on average 192 kcal/day more on PA (95 % CI, 127–256) than those with the lowest IC scores (range 26.5–63.0), while in older adults living in urban areas, those with the highest IC scores spent on average 89 kcal/day more on PA (95 % CI, 8–171). PA did not mediate the relationship between IC and falls.</div></div><div><h3>Conclusion</h3><div>Higher IC in older adults reduced fall risk and increased PA levels. Further research is needed on the acceptability and effectiveness of IC measurement in clinical practice.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105936"},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Beyond the “European health divide”: Functional limitation disparities among older adults in Central and Eastern Europe” [Archives of Gerontology and Geriatrics 136 (2025) 105908]","authors":"Shane D. Burns ,&nbsp;Liili Abuladze ,&nbsp;Luule Sakkeus","doi":"10.1016/j.archger.2025.105924","DOIUrl":"10.1016/j.archger.2025.105924","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105924"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors for multi-dimensional frailty of older adults in community: A systematic review and meta-analysis","authors":"Dongmei Yao ,&nbsp;Shenbi Yang ,&nbsp;Zhifei Wen ,&nbsp;Jing He ,&nbsp;Shuyang Ji ,&nbsp;Minhang Xia ,&nbsp;Hongyan Wang ,&nbsp;Xiangeng Zhang","doi":"10.1016/j.archger.2025.105935","DOIUrl":"10.1016/j.archger.2025.105935","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically evaluate the factors associated with multidimensional frailty assessed by the Tilburg Frailty Indicator among community-dwelling older adults.</div></div><div><h3>Methods</h3><div>A computerized search was conducted on ten databases, including CNKI, WanFang, VIP, CBM, PubMed, Web of Science, Embase, Scopus, Cochrane Library, and CINAHL, covering studies from inception to December 3, 2024. Literature screening, quality assessment, and data extraction were performed independently by two investigators, and meta-analysis was performed using STATA 18 software. The quality of the evidence was evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.</div></div><div><h3>Results</h3><div>A total of 28 articles with 138,924 participants were included, and 18 influencing factors were extracted. Meta-analysis results showed that: aged(OR=1.19), female(OR=1.53), marital status(no spouse) (OR=2.02), rural residence (OR=1.32), low education level(OR=2.53), fear of falling (OR=5.38), drinking (OR=1.20), smoking(OR=1.12), unhealthy lifestyle (OR=2.52), sleep disorders (OR=2.40), depression(OR=1.52), chronic diseases (OR=2.06), comorbidity (OR=2.08), self-rated poor health(OR=1.89), and hospitalization (OR=1.34) were risk factors for multidimensional frailty in community-dwelling older adults. Satisfaction with living conditions(OR=0.22), physical activity (OR=0.74), and consumption of tea (OR=0.53)were protective factors.</div></div><div><h3>Conclusion</h3><div>There are many factors involved in the incidence of multidimensional frailty in community-dwelling older adults by a meta-analysis. Screening for multidimensional frailty in community-dwelling older adults can be carried out early based on their risk factors, and corresponding measures can be taken according to the factors that can be intervened in order to delay or reduce the multidimensional frailty in community-dwelling older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105935"},"PeriodicalIF":3.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}