Archives of gerontology and geriatrics最新文献

{"title":"The impacts of multimorbidity trajectories and patterns on functional limitations over time in middle-aged and older adults","authors":"Yan Wu ,&nbsp;Xiao Niu ,&nbsp;Bosen Lv ,&nbsp;Xiaohui Li ,&nbsp;Weijing Wang ,&nbsp;Wenjing Feng ,&nbsp;Haiping Duan ,&nbsp;Yili Wu","doi":"10.1016/j.archger.2025.105919","DOIUrl":"10.1016/j.archger.2025.105919","url":null,"abstract":"<div><h3>Background</h3><div>Although multimorbidity is a risk factor for functional limitations, few studies have simultaneously examined the impacts of multimorbidity trajectories and patterns on long-term functional limitations change. We aim to identify multimorbidity trajectories and patterns and explore their relationships with functional limitations in middle-aged and older adults.</div></div><div><h3>Methods</h3><div>This study included 6302 participants aged ≥50 from the English Longitudinal Study of Ageing survey 2008–2021. Group-based trajectory model was conducted to identify multimorbidity trajectories from 22 chronic conditions (2008–2014). Exploratory factor analysis was employed to assess multimorbidity pattern using data collected in 2014. The impacts of multimorbidity trajectories and patterns on the change in functional limitations across the subsequent 7 years (2014–2021) were examined through generalized estimating equation models.</div></div><div><h3>Results</h3><div>This study identified four multimorbidity trajectories: low-maintaining, new-increasing, moderate-increasing, and high-maintaining trajectory and four multimorbidity patterns: multi-system, cardiovascular, vision impairment, and metabolic-skeletal patterns. Across all multimorbidity trajectories and patterns, functional limitations showed sustained increases over time, with levels consistently higher than reference groups (all <em>P</em> &lt; 0.001). There were significant interactions of multimorbidity trajectories and patterns with time, particularly for high-maintaining trajectory (T6:<em>β</em> = -0.218, <em>P</em> = 0.007; T7:<em>β</em> = -0.271, <em>P</em> = 0.004), multi-system pattern (T6:<em>β</em> = -0.323, <em>P</em> = 0.001; T7:<em>β</em> = -0.593, <em>P</em> &lt; 0.001), and metabolic-skeletal pattern (T6:<em>β</em> = -0.313, <em>P</em> &lt; 0.001; T7:<em>β</em> = -0.481, <em>P</em> &lt; 0.001), indicating the high-maintaining multimorbidity trajectory, multi-system and metabolic skeletal patterns accelerated the progression of functional limitations.</div></div><div><h3>Conclusions</h3><div>Implement targeted preventive interventions and personalized health management strategies for high-risk multimorbidity patients to delay disability onset.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105919"},"PeriodicalIF":3.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cachexia defined by the Asian Working Group for Cachexia 2023 criteria as a determinant of functional recovery in post-stroke patients capable of oral intake","authors":"Fumihiko Nagano ,&nbsp;Yoshihiro Yoshimura ,&nbsp;Ayaka Matsumoto ,&nbsp;Yoichi Sato ,&nbsp;Takafumi Abe ,&nbsp;Sayuri Shimazu ,&nbsp;Ai Shiraishi ,&nbsp;Takahiro Bise ,&nbsp;Yoshifumi Kido ,&nbsp;Takenori Hamada ,&nbsp;Aomi Kuzuhara ,&nbsp;Kouki Yoneda","doi":"10.1016/j.archger.2025.105921","DOIUrl":"10.1016/j.archger.2025.105921","url":null,"abstract":"<div><h3>Background and aims</h3><div>Cachexia is a common condition in stroke patients, yet its prevalence and impact on functional outcomes based on the Asian Working Group for Cachexia (AWGC) 2023 criteria remain unclear. This study aimed to determine the prevalence of cachexia and examine its association with functional prognosis in post-acute stroke patients capable of oral intake.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 856 post-stroke patients (mean (SD) age: 78 (7) years; 52 % men) admitted to a Japanese rehabilitation hospital between 2015 and 2023. Cachexia was diagnosed at admission using the AWGC 2023 criteria. Functional outcomes were assessed using the Functional Independence Measure (FIM)-motor score at discharge and FIM-motor gain. The association between cachexia and functional outcomes was analyzed using multiple linear regression, adjusting for age, sex, stroke type, baseline FIM-motor and FIM-cognitive scores, and other confounders.</div></div><div><h3>Results</h3><div>Cachexia was diagnosed in 20 % (172/856) of patients. The mean (SD) length of hospital stay was 85 (44) days. Stroke types were cerebral infarction (<em>n</em> = 634, 74 %), cerebral hemorrhage (<em>n</em> = 188, 22 %), and subarachnoid hemorrhage (<em>n</em> = 34, 4 %). The most common underlying diseases were cancer (<em>n</em> = 120, 14 %), chronic heart failure (<em>n</em> = 52, 6 %), and chronic kidney disease (<em>n</em> = 26, 3 %). After adjusting for confounders, cachexia remained independently associated with lower FIM-motor at discharge (β=-0.092, <em>P</em> = 0.009) and lower FIM-motor gain (β=-0.079, <em>P</em> = 0.024).</div></div><div><h3>Conclusion</h3><div>Cachexia, as defined by the AWGC 2023 criteria, was prevalent in post-stroke patients and negatively impacted functional recovery. Early identification and targeted interventions may be essential for improving rehabilitation outcomes and quality of life.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105921"},"PeriodicalIF":3.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful aging rates of global older adults: A subgroup meta-analysis","authors":"Xuan Zhang ,&nbsp;Yurong Liu ,&nbsp;Haixia Hao,&nbsp;Wen Li,&nbsp;Xiangrui Fu,&nbsp;Chenxiao Jia,&nbsp;Yuan Wang,&nbsp;Wenli Lu","doi":"10.1016/j.archger.2025.105920","DOIUrl":"10.1016/j.archger.2025.105920","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to assess the successful aging (SA) rates of individuals aged 60 and above in different subgroups based on gender, age, region, etc., in order to provide a scientific basis for improving the quality of life of the older adults.</div></div><div><h3>Setting and Participants</h3><div>Older adults (≥60 years).</div></div><div><h3>Methods</h3><div>A systematic review was conducted by searching six electronic databases including PubMed, Embase, CINAHL, Web of Science, SCOPUS, and PsycINFO as of July 17, 2023. Quality assessment, screening, data extraction, and analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. A total of 64 studies involving 546 228 individuals aged 60 and above were included, and subgroup analyses were conducted based on sex, age, region, study time, and study quality. Statistical analyses were conducted using Revman 5.3 and Stata 11.0.</div></div><div><h3>Results</h3><div>The SA rate was higher in males (26.0 %, 95 % CI 22.0 %-30.0 %) compared to females (19.0 %, 95 % CI 16.0 %-22.0 %). The SA rates in older adults in the 60–69 (36.0 %), 70–79 (30.0 %), and 80+ (19.0 %) age groups showed a decreasing trend. In regional subgroup analysis, SA rates were higher in North America (30.0 %) and South America (26.0 %), and lower in Asia (19.0 %), Africa (17.0 %), Oceania (16.0 %) and Europe (15.0 %). The SA rate before 2010 (26.0 %) was higher than that 2010 and after (22.0 %). Compared to low quality studies (18.0 %), high quality studies (27.0 %) had a higher SA rate.</div></div><div><h3>Conclusions and Implications</h3><div>The study found that males had a higher SA rate than females, and the SA rate decreased with age. There were regional differences in SA rates. Variations in economic and educational levels among different countries may affect the likelihood of achieving SA in the older population. Measures are recommended to improve the living conditions of older adults with low education and economic status.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105920"},"PeriodicalIF":3.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for in-hospital outcomes in older patients with hip fracture and atrial fibrillation: A Nationwide Inpatient Sample analysis","authors":"Kuan-Ju Chen ,&nbsp;Jr-Kai Chen","doi":"10.1016/j.archger.2025.105916","DOIUrl":"10.1016/j.archger.2025.105916","url":null,"abstract":"<div><h3>Purpose</h3><div>Older adults with pre-existing atrial fibrillation (AF) who sustain a hip fracture that requires surgery are at increased risk of morbidity and mortality. This study aims to identify predictors of in-hospital mortality and prolonged length of stay (LOS) in these patients.</div></div><div><h3>Methods</h3><div>The United States (US) Nationwide Inpatient Sample (NIS) database was retrospectively reviewed for patients ≥ 60 years old with AF who underwent surgical management of a hip fracture between 2016 and 2020. Outcomes evaluated were in-hospital mortality and prolonged LOS (≥ 7 days). Multivariable logistic regressions were performed to identify risk factors for these outcomes.</div></div><div><h3>Results</h3><div>Among 43,667 eligible patients, the strongest predictors for in-hospital mortality were sepsis (adjusted odds ratio [aOR] = 6.45), respiratory failure (aOR = 5.91), liver disorders (aOR = 2.61), and acute kidney injury (aOR = 2.40). Other predictors were pneumonia, advanced age, high Injury Severity Score (ISS ≥ 16), deep vein thrombosis, pulmonary embolism, and heart failure with reduced ejection fraction (HFrEF). For prolonged LOS, the strongest independent predictors included sepsis (aOR = 4.84), pneumonia (aOR = 3.25), deep vein thrombosis (aOR = 4.62), respiratory failure, and advanced age.</div></div><div><h3>Conclusion</h3><div>These results indicate the impact of critical complications and comorbidities on in-hospital mortality and LOS in elderly hip fracture patients with pre-existing AF. These findings particularly support the need for vigilance and enhanced perioperative management targeting sepsis, respiratory complications, and kidney function to improve outcomes in this high-risk group.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105916"},"PeriodicalIF":3.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative disadvantages in nursing home COVID-19 infections and deaths: implications of ownership status and location","authors":"Sungjae Hong,&nbsp;Shannon T. Mejía","doi":"10.1016/j.archger.2025.105918","DOIUrl":"10.1016/j.archger.2025.105918","url":null,"abstract":"<div><h3>Objective</h3><div>Disadvantages accumulated over the span of residents’ lives before nursing home placement can compound within nursing homes, potentially amplifying the effects of those disadvantages on resident outcomes. This study examined the extent to which nursing home location and ownership differentiated the outcome trajectories and susceptibility to the impact of momentary threats, the time-varying stressors that can influence COVID-19 outcomes during a specific period.</div></div><div><h3>Methods</h3><div>The COVID-19 Nursing Home Data provided weekly reports of COVID-19 infections and deaths from June 2020 to January 2021 from 11,088 nursing homes. Nursing homes were categorized by for-profit vs. not-for-profit ownership and rural vs. urban location. Momentary threats included the nursing home and county-level COVID-19 infection rate and staff shortage. Multilevel multinomial negative binomial regression nested weekly observations within nursing homes and tested the impact of nursing home factors on the trajectory and momentary threats.</div></div><div><h3>Results</h3><div>COVID-19 infection/mortality rates were higher in for-profit than in non-profit nursing homes, showing worsening disparities over time. At baseline, rural nursing homes had lower COVID-19 infection/mortality rates than urban nursing homes, but rural nursing homes reported higher rates than urban nursing homes over time. Weekly county-level COVID-19 infection had stronger impacts in rural nursing homes. However, the impact of weekly variation in nursing home COVID-19 infections on deaths was smaller in for-profit and rural nursing homes.</div></div><div><h3>Conclusion</h3><div>This study revealed cumulative disadvantage of nursing home characteristics in COVID-19 infections and deaths, implying the importance of addressing inequalities in prevention and control of COVID-19 within nursing homes.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105918"},"PeriodicalIF":3.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spillover effects of integrated care: Evidence from the impact of Home- and Community-Based Integrated Care for Older Adults (HCICOA) on spouses’ health and well-being in China","authors":"Yating Liu ,&nbsp;Chenlu Hong ,&nbsp;Guangwen Liu ,&nbsp;Yujie Huang ,&nbsp;Boyuan Guan ,&nbsp;Yanan Luo","doi":"10.1016/j.archger.2025.105907","DOIUrl":"10.1016/j.archger.2025.105907","url":null,"abstract":"<div><h3>Background</h3><div>Home- and Community-Based Integrated Care for Older Adults (HCICOA) has been rapidly implemented in China to address aging population needs. While its direct benefits for care recipients are well studied, its spillover effects on spouses remain underexplored. This study examines HCICOA’s impact on spouses' health and well-being.</div></div><div><h3>Methods</h3><div>Using panel data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, we employed a difference-in-differences (DID) approach to estimate HCICOA’s effects on spouses' happiness, life satisfaction, self-reported health, depressive symptoms, chronic diseases, and function status.</div></div><div><h3>Results</h3><div>HCICOA positively influenced spouses' happiness (β=0.322, <em>P</em> &lt; 0.01), especially among female spouses (β=0.369, <em>P</em> &lt; 0.05), rural residents (β=410, <em>P</em> &lt; 0.01), those with lower education (β=0.394, <em>P</em> &lt; 0.01) and those in western China. However, no significant effects were found on life satisfaction (β=0.084, <em>P</em> = 0.054), self-reported health (β=-0.025, <em>P</em> = 0.577), depressive symptoms (β=0.026, <em>P</em> = 929), chronic diseases (β=-0.046, <em>P</em> = 0.604), or function status (β=0.018, <em>P</em> = 0.860).</div></div><div><h3>Conclusions</h3><div>HCICOA has a positive spillover effect on spousal happiness, underscoring its broader social advantages. Policymakers should expand implementation of the HCICOA and adopt a family-centered approach in designing HCICOA program to further broaden its coverage and impact.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105907"},"PeriodicalIF":3.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social isolation and depression, and sex differences in older adults: A systematic review and meta-analysis","authors":"Yuyan Liu ,&nbsp;Yue Zhou ,&nbsp;Dan Sun ,&nbsp;Yuhang Wen ,&nbsp;Hui Zhao ,&nbsp;Yu Long ,&nbsp;Qiongge Yu ,&nbsp;Qiufeng Jia ,&nbsp;Yufeng Yu","doi":"10.1016/j.archger.2025.105915","DOIUrl":"10.1016/j.archger.2025.105915","url":null,"abstract":"<div><h3>Background</h3><div>Depression is the most common mental health problems worldwide. Although several studies have explored the relationship between social isolation and depression, the specific association and gender differences are still inconsistent.</div></div><div><h3>Objective</h3><div>To systematically evaluate the association between social isolation and depression, and sex differences in older adults.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, Web of Science, Cochrane Library, Scopus, and PsycINFO databases from inception to January 21, 2025. Two researchers independently conducted literature screening, data extraction, and quality evaluation. Meta-analysis was performed using Stata 17.0.</div></div><div><h3>Results</h3><div>This meta-analysis included a total of 11 studies, involving 103,408 older people from 7 different countries, which showed a significantly increased risk of depression in older adults who experienced social isolation (OR 1.46, 95 % CI 1.21–1.77). Sex differences analysis revealed that females (OR 1.59, 95 % CI 1.08–2.33) were at greater risk of depression compared to males (OR 0.98, 95 % CI 0.75–1.27). Subgroup analyses showed that the risk of depression was significantly increased in older people with advanced age and low education levels, and was significantly increased in both developed and developing countries, especially Europe and Asia. Cross-sectional and cohort studies also showed strong associations.</div></div><div><h3>Conclusions</h3><div>Social isolation significantly increases the risk of depression among older adults, with consistent findings across age, education level, region, and level of economic development. Analysis of gender differences suggests that older women are particularly affected. Strengthening the identification of social isolation in older people is essential to prevent depression in older people and promote successful aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105915"},"PeriodicalIF":3.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feedback mechanisms between physical frailty and cognitive declines in older community-dwelling adults: The Rancho Bernardo Study","authors":"Kai Zhang","doi":"10.1016/j.archger.2025.105870","DOIUrl":"10.1016/j.archger.2025.105870","url":null,"abstract":"<div><div>This study investigates bidirectional feedback mechanisms between physical frailty and cognitive decline in older adults using 12-year longitudinal data from the Rancho Bernardo Study. Frailty phenotypes were assessed through measures of body composition (appendicular lean mass, adjusted by BMI and height squared), weakness (handgrip strength), and physical functioning (Timed Up-and-Go test and 5-times chair stand test). Cognitive function was evaluated using the Mini-Mental State Examination (global cognitive function), Trail Making Test (executive function), Category Fluency Test (semantic memory), and Buschke–Fuld Selective Reminding Test (verbal episodic memory). We propose a mediation-based approach to model the temporal sequences within the complex system of frailty, and found significant reciprocal associations between physical and cognitive decline. For example, muscle strength fully mediated the association between prior body composition and subsequent cognitive functions, and vice versa. These findings advance the understanding of frailty as a dynamic, multifaceted syndrome by elucidating the direct and indirect pathways across its functional domains, highlighting muscle strength as a pivotal target for screening and interventions to mitigate frailty progression.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105870"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-fat interactions in aging–A call for mechanistic research to guide clinical practice","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105913","DOIUrl":"10.1016/j.archger.2025.105913","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105913"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between micronutrients and sarcopenia: a two-sample bidirectional Mendelian randomization study","authors":"Huilin Liu ,&nbsp;Jiahui Chen ,&nbsp;Shihao Ni ,&nbsp;Wenjie Long ,&nbsp;Xiaoming Dong ,&nbsp;Huili Liao ,&nbsp;Lu Lu ,&nbsp;Zhongqi Yang","doi":"10.1016/j.archger.2025.105917","DOIUrl":"10.1016/j.archger.2025.105917","url":null,"abstract":"<div><div>Sarcopenia, a geriatric syndrome in older adults, significantly impacts quality of life and elevates health risks. This study examines the causal relationships between specific micronutrients—magnesium, selenium, calcium, zinc, iron, phosphorus, and omega-3 fatty acids—and sarcopenia-related traits (SP-traits) using Mendelian randomization (MR) based on genome-wide association studies (GWAS). A bidirectional two-sample MR analysis was performed using data from fourteen GWAS, focusing on five SP-traits: low hand grip strength, moderate-to-vigorous physical activity (MVPA), ability to walk or cycle unaided for 10 min (AWCU10), usual walking pace, and adjusted appendicular lean mass (ALM). The analysis identified 14 single nucleotide polymorphisms (SNPs) linked to zinc levels and MVPA, and 12 SNPs associated with usual walking pace. Concerning ALM, 72 SNPs were associated with magnesium and 81 with omega-3 fatty acids. Significant associations were noted between zinc levels and MVPA (beta = 0.85, <em>P</em> = 0.026) and usual walking pace (beta = 0.53, <em>P</em> = 0.008). The reverse MR analysis revealed a positive correlation between ALM and magnesium (beta = 0.126, <em>P</em> = 0.0004) and a nominally significant negative correlation with omega-3 (beta = -0.083, <em>P</em> = 0.008). While some heterogeneity was noted, no pleiotropy was detected, reinforcing the robustness of the findings. This study highlights the importance of magnesium, zinc, and omega-3 fatty acids in muscle health and advocates for their inclusion in public health strategies to enhance the physical function and quality of life in older adults. Further research is needed to validate these findings across diverse populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105917"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}