Archives of gerontology and geriatrics最新文献

{"title":"Life-course socioeconomic inequalities, social mobility and healthy aging in older adults: A multi-cohort study","authors":"Ziting Huang ,&nbsp;Eric T.C. Lai ,&nbsp;Hideki Hashimoto ,&nbsp;Michael Marmot ,&nbsp;Jean Woo","doi":"10.1016/j.archger.2025.105829","DOIUrl":"10.1016/j.archger.2025.105829","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate how socioeconomic positions at different life stages, their relative importance, and social mobility influence IC across the USA, UK, Europe, China, and Japan among adults aged ≥50 years.</div></div><div><h3>Methods</h3><div>We included 54,217 participants from five nationally representative cohorts in the USA, UK, Europe, China, and Japan. Life-course socioeconomic positions were assessed in early-life (childhood socioeconomic positions), early-adulthood (education), and late-adulthood (household wealth). Healthy aging was measured by intrinsic capacity including cognition, psychological health, locomotion, vitality, and sensory functions. Linear mixed models were used to estimate the associations of intrinsic capacity with each socioeconomic position indicator and social mobility.</div></div><div><h3>Findings</h3><div>Higher levels of education and wealth were both significantly associated with better intrinsic capacity (<em>p</em> &lt; 0.05 in all cohorts).</div><div>Education had a stronger impact on intrinsic capacity than wealth in the USA, Europe, China, and Japan. Middle and high childhood socioeconomic positions were significantly linked to better intrinsic capacity compared with the low group (<em>p</em> &lt; 0.05 in all cohorts). Compared to stable groups, upward and downward social mobility groups were associated with better and worse intrinsic capacity, respectively.</div></div><div><h3>Conclusion</h3><div>Socioeconomic measures throughout the life course can predict healthy aging in the USA, Europe, and Asia. The long-term negative impact of disadvantaged childhood socioeconomic positions on healthy aging can be partially mitigated by upward mobility later in life. Policies need to narrow the social inequalities from early life and prevent adults from experiencing downward mobility, thereby reducing disparities in healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105829"},"PeriodicalIF":3.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burdens of hip fractures in elderly individuals from 1990 to 2021 and predictions up to 2050: A systematic analysis of the Global Burden of Disease Study 2021","authors":"Chuwei Tian ,&nbsp;Liu Shi ,&nbsp;Jinyu Wang ,&nbsp;Jun Zhou ,&nbsp;Chen Rui ,&nbsp;Yueheng Yin ,&nbsp;Wei Du ,&nbsp;Shimin Chang ,&nbsp;Yunfeng Rui","doi":"10.1016/j.archger.2025.105832","DOIUrl":"10.1016/j.archger.2025.105832","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to analyse the global, regional, and national burdens of hip fractures in older adults from 1990 to 2021, with projections to 2050, on the basis of data from the GBD 2021 study.</div></div><div><h3>Methods</h3><div>We employed a joinpoint model to analyse trends in the burden of hip fractures from 1990‒2021. The estimated annual percentage change (EAPC) was used to quantify temporal trends over this period. We evaluated the relationship between the social development index and the burden of hip fracture in elderly people and conducted a health inequality analysis. Additionally, we applied Long-short Term Memory (LSTM) networks to forecast burden trends of hip fractures up to 2050.</div></div><div><h3>Results</h3><div>The global age-standardized incidence rate (ASIR) for hip fractures in older adults rose from 781.56 per 100,000 in 1990 to 948.81 in 2021. The 2021 age-standardized prevalence rate (ASPR) was 1,894.07, and the age-standardized YLD rate (ASDR) was 173.52. From 1990 to 2021, the incidence and prevalence increased by 168.71 % and 173.07 %, respectively, while the burden of DALYs decreased. Future trends were projected via the LSTM. The burden and risk factors for hip fractures varied significantly by sex, country, and region. Population and aging are primary contributors to the rising incidence of elderly hip fractures, with falls being the leading direct cause.</div></div><div><h3>Conclusion</h3><div>From 1990 to 2021, the global burden of hip fractures in the elderly population, especially among older women, steadily increased. Population ageing highlights the urgent need for targeted public health interventions and resource allocation, including early diagnosis, effective prevention strategies, and region-specific management approaches.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105832"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Age Gap Associations with Body Composition and Metabolic Indices in an Asian Cohort: An MRI-Based Study","authors":"Han-Jui Lee ,&nbsp;Chen-Yuan Kuo ,&nbsp;Yu-Chung Tsao ,&nbsp;Pei-Lin Lee ,&nbsp;Kun-Hsien Chou ,&nbsp;Chung-Jung Lin ,&nbsp;Ching-Po Lin","doi":"10.1016/j.archger.2025.105830","DOIUrl":"10.1016/j.archger.2025.105830","url":null,"abstract":"<div><h3>Background</h3><div>Global aging raises concerns about cognitive health, metabolic disorders, and sarcopenia. Prevention of reversible decline and diseases in middle-aged individuals is essential for promoting healthy aging. We hypothesize that changes in body composition, specifically muscle mass and visceral fat, and metabolic indices are associated with accelerated brain aging. To explore these relationships, we employed a brain age model to investigate the links between the brain age gap (BAG), body composition, and metabolic markers.</div></div><div><h3>Methods</h3><div>Using T1-weighted anatomical brain MRIs, we developed a machine learning model to predict brain age from gray matter features, trained on 2,675 healthy individuals aged 18–92 years. This model was then applied to a separate cohort of 458 Taiwanese adults (57.8 years ± 11.6; 280 men) to assess associations between BAG, body composition quantified by MRI, and metabolic markers.</div></div><div><h3>Results</h3><div>Our model demonstrated reliable generalizability for predicting individual age in the clinical dataset (MAE = 6.11 years, <em>r</em> = 0.900). Key findings included significant correlations between larger BAG and reduced total abdominal muscle area (<em>r</em> = -0.146, <em>p</em> = 0.018), lower BMI-adjusted skeletal muscle indices, (<em>r</em> = -0.134, <em>p</em> = 0.030), increased systemic inflammation, as indicated by high-sensitivity C-reactive protein levels (<em>r</em> = 0.121, <em>p</em> = 0.048), and elevated fasting glucose levels (<em>r</em> = 0.149, <em>p</em> = 0.020).</div></div><div><h3>Conclusions</h3><div>Our findings confirm that muscle mass and metabolic health decline are associated with accelerated brain aging. Interventions to improve muscle health and metabolic control may mitigate adverse effects of brain aging, supporting healthier aging trajectories.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105830"},"PeriodicalIF":3.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From patterns to pathways: Latent class trajectories of self-perceptions of aging and their causal effects on multi-state functional transitions","authors":"Lingjun Liu ,&nbsp;Boshu Mao ,&nbsp;Fei Ji","doi":"10.1016/j.archger.2025.105827","DOIUrl":"10.1016/j.archger.2025.105827","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the heterogeneous developmental trajectories of self-perceptions of aging (SPA) and their causal effects on functional health transitions in older adults. Specifically, we aim to identify latent classes of SPA development, assess their impact on multi-state functional transitions, and quantify the loss in healthy life expectancy attributable to negative SPA.</div></div><div><h3>Methods</h3><div>Drawing from the Chinese Longitudinal Healthy Longevity Survey (2008–2018; <em>n</em> = 14,020), we implemented latent class trajectory modeling to identify SPA developmental patterns. We then applied multi-state Markov models to examine the effects of SPA on transitions among functional states (fully independent, assistance needed, and deceased), and established a counterfactual framework to estimate the loss in multi-state life expectancy attributable to SPA.</div></div><div><h3>Results</h3><div>Analysis revealed two distinct SPA trajectories: a high-level group (57.75 %) and a low-level group (42.25 %), both exhibiting declining trends while maintaining consistent level differences. After adjusting for demographic characteristics, negative SPA significantly increased the risk of functional impairment (HR=1.31, 95 % CI: 1.20–1.44) and diminished the probability of functional recovery (HR=0.61, 95 % CI: 0.53–0.71). At age 65, negative SPA was associated with a 2.18-year reduction in total life expectancy, with substantial disparities in healthy life expectancy (10.93 vs. 7.96 years).</div></div><div><h3>Discussion</h3><div>This study reveals two distinct trajectories of SPA in later life and demonstrates its causal effects on health state transitions. Early interventions targeting negative aging perceptions, particularly before age 65, may effectively extend healthy life expectancy.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105827"},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical frailty and social support in community-dwelling older adults: A systematic review","authors":"Xiaofan Dou ,&nbsp;Lifeng Yao ,&nbsp;Hai Xu ,&nbsp;Ruijian Yan ,&nbsp;Nannan Dai ,&nbsp;Qiao He","doi":"10.1016/j.archger.2025.105826","DOIUrl":"10.1016/j.archger.2025.105826","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults with frailty have an increased likelihood of unmet care needs, falls and fractures and so on, which brings serious burdens to society. By evaluating the association between physical frailty and social support in community-dwelling older adults, we will provide reference for preventing the occurrence of frailty.</div></div><div><h3>Methods</h3><div>Cross-sectional and longitudinal studies on association between frailty and social support in community-dwelling older adults were mainly searched from the database of Medline, Embase, PsycINFO, CINAHL Plus and Web of Science from their establishment to February 16, 2024. After literature screening, two researchers completed data extraction, and the risk of bias was assessed using the 8-item Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies for cross-sectional studies and the Newcastle-Ottawa Scale for Cohort Studies for longitudinal studies.</div></div><div><h3>Results</h3><div>The study included a total of 14 articles, including 9 cross-sectional studies and 5 longitudinal studies. There was no clear consensus on the correlation between social support and frailty among community-dwelling older adults. The overall quality of the included studies was very high.</div></div><div><h3>Conclusion</h3><div>Although the correlation between social support and frailty among community-dwelling older adults needs further verification, given the important role of social support, it is still recommended that family members provide multi-faceted social support, especially subjective support, for older adults.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105826"},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of group reminiscence therapy assisted by memory specificity training (GRT-mest) on depressive symptoms in older adults: A cluster randomized controlled trial","authors":"Yuejin Wu ,&nbsp;Tianzhuo Yu ,&nbsp;Yuanjian Xia ,&nbsp;Yuewei Li ,&nbsp;Lirong Guo ,&nbsp;Xin Leng ,&nbsp;Ting Zeng ,&nbsp;Xinyang Bai ,&nbsp;Lijuan Zhang ,&nbsp;Xuejiao Wu ,&nbsp;Haiyan Xu ,&nbsp;Yanwei Du ,&nbsp;Feng Li","doi":"10.1016/j.archger.2025.105811","DOIUrl":"10.1016/j.archger.2025.105811","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the effects of the Group Reminiscence Therapy assisted by Memory Specificity Training (GRT-mest) in older adults, and to further investigate the indirect effect of autobiographical memory in improving depressive symptoms.</div></div><div><h3>Methods</h3><div>In this single-blind, three-arm parallel group, cluster randomized controlled trial, 78 eligible participants were randomly assigned to two intervention groups and one control group in two nursing homes, and assessments were conducted at baseline, immediately post-intervention, and 1-month and 3-month follow-ups. Data analysis was performed using SPSS 26.0.</div></div><div><h3>Results</h3><div>The GRT-mest had more significant improvements in depressive symptoms (ES=0.08, <em>P</em> &lt; 0.001), autobiographical memory (ES=0.07, <em>P</em> &lt; 0.001), and rumination (ES=0.07, <em>P</em> &lt; 0.001) compared to other two groups, and these effects were maintained up to 3 months post-intervention. The improvement of autobiographical memory only had an indirect effect on improving depressive symptoms at immediately post-intervention (Indirect effect =-1.3231, 95% CI [-2.4187, -0.4053], <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The GRT-mest can improve depressive symptoms, autobiographical memory, and rumination in older adults, with these effects being maintained for up to 3 months. Additionally, the improvement in autobiographical memory plays a short-term mediating role in alleviating depressive symptoms. This study further supports the theoretical effectiveness of incorporating mest into the treatment of depressive symptoms among older adults in domestic settings.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105811"},"PeriodicalIF":3.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FP receptor inhibits autophagy to aggravate aging-related cardiac fibrosis through PI3K/AKT/mTOR signaling pathway","authors":"Jia Qi ,&nbsp;Bin Lu ,&nbsp;Cheng-wei Jin ,&nbsp;Yuan-yuan Shang ,&nbsp;Hui Pan ,&nbsp;Hao Li ,&nbsp;Zhou-jie Tong ,&nbsp;Wei Zhang ,&nbsp;Lu Han ,&nbsp;Ming Zhong","doi":"10.1016/j.archger.2025.105824","DOIUrl":"10.1016/j.archger.2025.105824","url":null,"abstract":"<div><h3>Background</h3><div>F-prostanoid receptor (FP receptor), a receptor for Prostaglandin F2α(PGF2α), is involved in the process of tissue fibrosis, but its exact role in the aging heart remains unclear.</div></div><div><h3>Methods</h3><div>We investigated cardiac function, myocardial fibrosis levels, autophagy levels and related mechanistic pathways in different groups of mice using gene silencing. At the cellular level, we simulated the senescence process of cardiac fibroblasts and investigated the related mechanisms using relevant inhibitors.</div></div><div><h3>Results</h3><div>In aging mice, FP receptor and PI3K/AKT/mTOR pathways are increased and autophagy levels are decreased, ultimately leading to cardiac fibrosis. FP receptor gene silencing slows down the above process. We found similar changes at the cellular level.</div></div><div><h3>Conclusion</h3><div>FP receptor could activate PI3K/AKT/mTOR pathway and inhibit cardiac autophagy, which resulted in aging-related cardiac fibrosis. Thus, the inhibition of FP receptor could improve aging-related cardiac remodeling, implicating its potential therapeutic application to treat cardiovascular diseases associated with aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105824"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults","authors":"Brendan L. McNeish ,&nbsp;Iva Miljkovic ,&nbsp;Matthew A. Allison ,&nbsp;Timothy Hughes ,&nbsp;Ilya Nasrallah ,&nbsp;Eric Terkpertey ,&nbsp;Caterina Rosano","doi":"10.1016/j.archger.2025.105823","DOIUrl":"10.1016/j.archger.2025.105823","url":null,"abstract":"<div><h3>Background</h3><div>Prior research linking myosteatosis with cognition in older adults has been conducted in relatively homogenous populations with narrow age ranges. We evaluated if abdominal myosteatosis was associated with processing speed in a multiethnic cohort of middle aged and older adults.</div></div><div><h3>Methods</h3><div>The sample included 1,268 adults (46–86 years-old, mean 63±9 years, 53 % female, 41 % White, 20 % Black, 14 % Chinese, and 25 % Hispanic), a subset from the Multi-Ethnic Study of Atherosclerosis. Bivariate analyses examined the relationships between abdominal computed tomography-derived muscle density (measure of myosteatosis) at clinical exam 3, Digit Symbol Coding (DSC) performance at clinical exam 5, and cytokine levels from clinical exam 1. Multivariable models were adjusted for demographics, education, general cognition, and further adjusted for other known predictors of dementia: <em>APOE</em>-4, physical activity, diabetes, cholesterol, smoking, and blood pressure. We assessed whether central adiposity, general adiposity, and cytokines modified this association. We tested interactions by ethnicity, sex, and age.</div></div><div><h3>Results</h3><div>Rectus abdominis myosteatosis was significantly associated with worse DSC (B=-0.247, 95 % CI: 0.098,0.396, p = 0.001) independent of demographics, education, general cognition, and dementia risk factors. Adjustment for central adiposity, and cytokines did not attenuate the associations and interactions by ethnicity, sex, and age were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Rectus abdominis myosteatosis is associated with worse processing speed in this middle and older aged multiethnic population of men and women, independent of known predictors of cognition. Longitudinal studies should assess the interplay of myosteatosis with other markers of adiposity, inflammation, and circulating mediators and their impact on processing speed.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105823"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The temporal trend in frailty prevalence from 2011 to 2020 and disparities by equity factors among middle-aged and older people in China: A population-based study","authors":"Dongfeng Tang ,&nbsp;Katie J Sheehan ,&nbsp;Aicha Goubar ,&nbsp;Julie Whitney ,&nbsp;Matthew DL O'Connell","doi":"10.1016/j.archger.2025.105822","DOIUrl":"10.1016/j.archger.2025.105822","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a challenging issue in China, however the prevalence of frailty across different population groups and whether this is changing over time remain unclear.</div></div><div><h3>Methods</h3><div>Unstandardized and age-and sex-standardized prevalence of frailty (95 % confidence interval (95 % CI)) (Frailty Index) in the overall sample and for subgroups defined by equity factors (PROGRESS-Plus framework) from 2011 to 2020 were estimated using analyses of cross-sectional surveys in adults aged 45 and older participating in 5 waves (<em>N</em> = 16,784 to 18,904 across waves) of the China Health and Retirement Longitudinal Studies (CHARLS). Poisson regression was used to estimate prevalence ratios (PRs) of frailty by equity factors.</div></div><div><h3>Results</h3><div>Unstandardized prevalence of frailty increased from 13.6 % (13.0 %-14.1 %) in 2011 to 18.7 % (18.1 %-19.3 %) in 2020.The standardized prevalence increased from 13.5 % (13.0 %-14.0 %) in 2011 to 16.3 % (15.8 %-16.9 %) in 2020. Frailty was consistently more prevalent at advanced ages, in rural areas, among females, as well as those less educated, without social engagement, and non-drinkers. Based on the Poisson regression model, non-north region, being female and older, lower education, having no social engagement, smoking and non-drinking, and higher household capital consumption were associated with higher prevalence.</div></div><div><h3>Conclusions</h3><div>The prevalence of frailty among the middle-aged and older population in China has increased. There will be an associated health and social care cost. Interventions targeted at older adults, those in rural areas, women, as well as those less educated, having no social engagement, and non-drinkers to mitigate the negative effects of frailty may be warranted.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105822"},"PeriodicalIF":3.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social context matters: Neighborhood environment as a moderator of the longitudinal relationship between edentulism and cognitive function among older adults in the United States","authors":"Ruotong Liu ,&nbsp;Xiang Qi ,&nbsp;Weiyu Mao ,&nbsp;Huabin Luo ,&nbsp;Zhijing Xu ,&nbsp;Bei Wu","doi":"10.1016/j.archger.2025.105806","DOIUrl":"10.1016/j.archger.2025.105806","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has shown poor oral health and neighborhood environment are both risk factors for cognitive decline among older adults. Little research has assessed the synergistic effects of poor oral health and neighborhood environment on cognitive health. This study examined whether neighborhood environment moderates the relationship between edentulism and cognitive function over time.</div></div><div><h3>Methods</h3><div>Using data from the Health and Retirement Study, we analyzed 9,994 adults aged 60 and older with 39,976 person-wave observations over 14 years (2006–2020). Cognitive function was measured using the modified Telephone Interview for Cognitive Status. Edentulism status was self-reported complete tooth loss. Neighborhood environment included perceived neighborhood cohesion and disorder. We used linear mixed-effect models to examine the moderation effect of neighborhood environment on the association between edentulism and cognitive function over time.</div></div><div><h3>Results</h3><div>Edentulous participants (22.4 %) showed an accelerated decline over time in cognitive function compared to dentate participants (β = -0.57, 95 % CI: -0.98, -0.16). The analysis revealed that neighborhood cohesion moderated the relationship between edentulism and cognitive function over time (β = 0.08, 95 % CI: 0.01, 0.15). Specifically, among individuals reporting higher neighborhood cohesion, the negative effect of edentulism on cognitive decline was attenuated. Neighborhood disorder had no significant associations with cognitive function.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the relationship between edentulism and cognitive function varies by levels of neighborhood cohesion. The findings highlight the significance of neighborhood context in understanding the relationship between oral health and cognitive aging and suggest interventions addressing community environment may be particularly relevant for older adults with oral health challenges.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105806"},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}