Archives of gerontology and geriatrics最新文献

{"title":"The molecular mechanisms of steroid hormone effects on cognitive function","authors":"Hai Duc Nguyen ,&nbsp;Giang Huong Vu ,&nbsp;Woong-Ki Kim","doi":"10.1016/j.archger.2024.105684","DOIUrl":"10.1016/j.archger.2024.105684","url":null,"abstract":"<div><h3>Objective</h3><div>There is a lack of information on the molecular mechanisms by which steroid hormones (testosterone, estrogen, and progesterone) regulate cognitive impairment. Thus, we aimed to identify the protective effects of steroid hormones on cognitive function.</div></div><div><h3>Methods</h3><div>We analyzed the literature on the molecular mechanisms, biological activities, physicochemical properties, and pharmacokinetics of steroid hormones.</div></div><div><h3>Results</h3><div>Steroid hormones can protect against cognitive impairment by regulating key genes (INS, TNF, STAT3, ESR1). Specific microRNAs, namely hsa-miR-335-5p, hsa-miR-16-5p, and hsa-miR-26b-5p, along with transcription factors NFKB1, PPARG, NR3C1, GATA2, EGR1, ATF3, and CEBPA, play a significant role in this protective mechanism. The involvement in cognitive processes, regulation of phosphorylation, neuronal apoptosis, and signaling pathways related to Alzheimer's disease significantly influence the protein-protein interaction network underlying these effects. Additionally, steroid hormones exhibit anti-hypercholesterolemic properties, anti-inflammatory activity, antitoxic properties, and function as inhibitors of acetylcholine neuromuscular transmission. They also hold promise as therapeutic agents for the treatment of dementia. Promising therapeutic interventions for cognitive impairment include the use of miRNA sponges targeting hsa-miR-16-5p, along with the administration of capsaicin, minocycline, dopamine, sertraline, and minaprine. The gut microbiota species <em>Lactobacillus amylovorus, Paraprevotella clara, Libanicoccus massiliensis, Prevotella oris, Turicibacter sanguinis</em>, and <em>Dubosiella newyorkensis</em> were identified as significant contributors to cognitive impairment and altered levels of steroid hormones.</div></div><div><h3>Conclusion</h3><div>Steroid hormones are promising compounds for improving cognitive function. Further research is needed to validate these findings through focused investigations into apoptosis, regulation of neuronal cell death, miRNA sponges, interactions with gut microbiota, and the potential efficacy of pharmaceutical agents.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105684"},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing of the Nrf2 pathway in aging promotes a decrease in the anti-inflammatory effect of resveratrol","authors":"Filipe Nogueira Franco,&nbsp;Brenda Evangelista Peixoto,&nbsp;Glaucy Rodrigues de Araújo,&nbsp;Miriam Martins Chaves","doi":"10.1016/j.archger.2024.105694","DOIUrl":"10.1016/j.archger.2024.105694","url":null,"abstract":"<div><div>During aging, in addition to increased oxidative stress, inflammation also occurs. A chronic and low-grade inflammation - called “inflammaging” - develops, which contributes to the etiology of diseases related to aging. Resveratrol (Resv.) is a polyphenol well known for its biologically active properties, such as antioxidant and anti-inflammatory properties. This balance can be regulated by Nrf2 - a transcription factor that regulates cellular defense against oxidative agents through the expression or inhibition of certain genes. The objective was to evaluate the effect of Nrf2 on the production of cytokines in leukocytes of different ages treated with resveratrol (5µm). The subjects were divided into three groups: 20–39, 40–59 and 60–80 years old. After separation of the leukocytes, a 24-hour treatment was carried out with and without ML385 inhibitor with the treatments: Control, Resv, Peroxide and Peroxide+Resv. 150 µM peroxide was set to develop an oxidative environment. Cytokines were measured by ELISA (*<em>p</em> &lt; 0.05). In general, there was an increase in TNF and IL-6 in cells stimulated with peroxide compared to controls. A decrease in these two cytokines was also observed in cells treated with resveratrol, both at basal levels and in an oxidizing environment (with peroxide). The polyphenol was able to increase IL-10 only in the youngest age groups. The same profile was observed comparing the same groups when the Nrf2 pathway was inhibited with ML385. It is concluded that resveratrol may have a better effect on preventing oxidation and inflammation present in aging, especially through the antioxidant and anti-inflammatory Nrf2 pathway.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105694"},"PeriodicalIF":3.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune-inflammation index and 2-year all-cause mortality in elderly patients with hip fracture","authors":"Shuhuai Tan ,&nbsp;Yu Jiang ,&nbsp;Kaihua Qin ,&nbsp;Yan Luo ,&nbsp;Dingfa Liang ,&nbsp;Yong Xie ,&nbsp;Xiang Cui ,&nbsp;Junsong Wang ,&nbsp;Houchen Lyu ,&nbsp;Licheng Zhang","doi":"10.1016/j.archger.2024.105695","DOIUrl":"10.1016/j.archger.2024.105695","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the association between systemic immune-inflammation index (SII) and 2-year all-cause mortality in elderly patients with hip fractures.</div></div><div><h3>Methods</h3><div>We performed a cohort study of hip fracture patients aged 65 years or older who received hip fracture surgery at a tertiary hospital from January 2005 to March 2022. The SII was calculated as: SII = (neutrophil count * platelet count) / lymphocyte count, based on the latest blood test before discharge. Patients were categorized into 3 groups according to SII tertiles: low SII group (≤770.92 × 10⁹/L), medium SII group (770.92 × 10⁹/L -1293.03 × 10⁹/L), and high SII group (&gt;1293.03 × 10⁹/L). The primary outcome was 2-year all-cause mortality. We evaluated the association between SII and 2-year all-cause mortality using the multivariate Cox regression model.</div></div><div><h3>Results</h3><div>Among 2766 patients, 296 patients died during the 2-year follow-up period. The incidence of 2-year all-cause mortality per 1000 persons was 90.0 (95 % CI: 73.2–110.2) in the low SII group, 86.8 (95 % CI: 70.3–106.7) in the medium SII group, and 144.3 (95 % CI: 123.1–168.5) in the high SII group. Compared with patients in the low SII group, the hazard ratio for 2-year all-cause mortality was 0.97 (95 % CI: 0.69–1.37) in the medium SII group and 1.47 (95 % CI: 1.07–2.01) in the high SII group (<em>P</em> for trend, 0.010).</div></div><div><h3>Conclusion</h3><div>SII is significantly associated with 2-year all-cause mortality in elderly patients with hip fracture. SII may be used to identify patients at high risk of mortality after hip fracture surgery.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105695"},"PeriodicalIF":3.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intrinsic capacity with incident type 2 diabetes mellitus in older Chinese: Guangzhou Biobank Cohort Study","authors":"Wei Xiang Gao ,&nbsp;Jia Liu ,&nbsp;Jiao Wang ,&nbsp;Ya Li Jin ,&nbsp;Shiu Lun Au Yeung ,&nbsp;Tai Hing Lam ,&nbsp;Wei Sen Zhang ,&nbsp;Lin Xu","doi":"10.1016/j.archger.2024.105687","DOIUrl":"10.1016/j.archger.2024.105687","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization introduced intrinsic capacity (IC) as a metric for healthy aging. However, we found no report on the association between IC and type 2 diabetes mellitus (T2DM). We investigated the association between IC and incident T2DM in older Chinese from the Guangzhou Biobank Cohort Study.</div></div><div><h3>Methods</h3><div>IC was assessed across five domains equally: locomotion, vitality, cognition, psychological and sensory. Composite IC scores (0–10) were classified into three groups: poor (0–5.9), fair (6.0–8.9), and high (9.0–10), with higher scores representing greater IC. Multivariable linear regression and cox regression was used to analyze the association between IC with glycemia and T2DM, respectively.</div></div><div><h3>Results</h3><div>Of 3582 participants with a mean age of 59.1 years (standard deviation (SD)=7.13) without baseline diabetes, during an average follow-up of 3.3 years (SD=0.86), 497 (13.87%) developed T2DM. After adjustments for potential confounders, those with baseline poor IC, versus high, had higher fasting glucose, 2-hour post-load glucose and glycosylated hemoglobin A_1c at follow-up, and a higher risk of incident T2DM (HR (95%CI): 1.80 (1.20, 2.72)). Among IC domains, only vitality impairment was associated with an increased risk of T2DM (P for trend &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>We first reported the prospective associations of poor IC and vitality with higher glycemia and incident T2DM risk. Enhancing muscle strength to improve functional ability may be a possible intervention for reducing future risk of T2DM in older populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105687"},"PeriodicalIF":3.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding loneliness after widowhood: The role of social isolation, social support, self-efficacy, and health-related factors","authors":"Rosanne Freak-Poli ,&nbsp;Htet Lin Htun ,&nbsp;Achamyeleh Birhanu Teshale ,&nbsp;Claryn Kung","doi":"10.1016/j.archger.2024.105692","DOIUrl":"10.1016/j.archger.2024.105692","url":null,"abstract":"<div><h3>Background</h3><div>Widowhood negatively affects trajectories of social isolation and loneliness. Given the inevitability of spousal bereavement for many, further investigation into potential modifiers of bereavement-related loneliness is warranted.</div></div><div><h3>Aim</h3><div>To examine the moderating effects of social isolation, social support, sociodemographic, self-efficacy, health, and quality of life factors on changes in loneliness before and after widowhood.</div></div><div><h3>Methods</h3><div>We analysed 19 waves of data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey, comprising 749 widowed and 8,418 married individuals (comparison). Coarsened exact matching weights were applied, controlling for age and time trends. Local polynomial smoothed plots illustrated social health trajectories from three years before to three years after spousal death. All analyses were gender-stratified.</div></div><div><h3>Results</h3><div>Low social isolation and higher social support did not prevent increased loneliness following widowhood. Men in major cities were less likely to experience reductions in social isolation during bereavement, despite being less socially-isolated at baseline than men in regional/remote areas. The bereavement-loneliness relationship was consistent across all subgroups. For men, this relationship was weakened by older age and being born in a non-English-speaking country, but strengthened by poverty and living in a regional/remote areas. For women, it was weakened by older age, and strengthened by factors such as being born in a non-English-speaking country, poverty, employment or volunteering, and having a long-term mental health condition.</div></div><div><h3>Conclusion</h3><div>Loneliness is a common and potentially unavoidable experience during widowhood, highlighting the importance of screening by healthcare workers to improve wellbeing and prevent future mental health issues.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105692"},"PeriodicalIF":3.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the relationship between participation in salons aimed at care prevention through the promotion of social participation and the subsequent cost of care: A 3-year prospective follow-up study in JAGES","authors":"Hiroshi Hirai ,&nbsp;Masashige Saito ,&nbsp;Tokunori Takeda ,&nbsp;Katsunori Kondo","doi":"10.1016/j.archger.2024.105688","DOIUrl":"10.1016/j.archger.2024.105688","url":null,"abstract":"<div><div>Many previous studies have found that social participation improves the health and functional maintenance of older people. However, to determine whether promoting social participation can prevent functional decline in the elderly, it is necessary not only to compare the prognosis of those who participate in social activities to those who do not but also to demonstrate that the intervention was effective in promoting social participation. Although the effect of social participation in preventing caregiving has been demonstrated, the key question is whether preventing functional decline through social participation can reduce care costs. This study aims to examine the relationship between participation in salons aimed at care prevention through the promotion of social participation and the subsequent cost of care. We use the Japan Gerontological Evaluation Study (JAGES) dataset to conduct longitudinal, individuallevel analysis. We focus on all residents 65 years and older who did not have a without disability in Taketoyo town and ran three regression analyses. First, a generalized linear model (GLM) with Tweedie distribution and log-link function, as well as robust estimation of variance components was used to estimate the dependent variables. Second, we used an inverse probability weighting (IPW) model to minimize selection bias. Finally, we performed the IV analysis. In this study, the GLM with IPW and IV models revealed link between salon participants and lower caregiving costs. The link between participation and caregiving costs was confirmed in a model with reduced selection bias, rather than in a simple GLM model.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105688"},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited role of biological aging in unhealthy aging: A cross-sectional analysis of global life expectancy and disability data","authors":"Wenpeng You ,&nbsp;Luisa Garcia ,&nbsp;Kamal Hezam ,&nbsp;Hui Chen (Rita) Chang","doi":"10.1016/j.archger.2024.105691","DOIUrl":"10.1016/j.archger.2024.105691","url":null,"abstract":"<div><h3>Background</h3><div>Biological aging is known to impact quality of life, but its precise role is debated.</div></div><div><h3>Objective</h3><div>This study explores how biological aging, measured by life expectancy at birth (e0), affects unhealthy aging as indicated by years lost due to disability (YLD).</div></div><div><h3>Methods</h3><div>Data from international organizations, including e0, YLD, and confounding factors like income, obesity, and urbanization, were analyzed. Correlations were visualized with scatter plots, and associations were assessed using Pearson's and nonparametric methods. Partial, multilevel modelling and multiple regression analyses were conducted to determine e0′s impact on YLD.</div></div><div><h3>Results</h3><div>e0 strongly correlated with YLD, explaining about 50 % of its variance. After adjusting for confounders, e0’s contribution fell to 12.18 %. Multiple regression identified e0 and urbanization as significant predictors.</div></div><div><h3>Conclusions</h3><div>Biological aging influences YLD, but its effect diminishes when accounting for other factors, highlighting the need for a comprehensive approach to healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105691"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in senescence markers after a weight loss intervention in older adults with obesity","authors":"David H. Lynch ,&nbsp;Curtis L. Petersen ,&nbsp;Delisha Stewart ,&nbsp;Jamie N. Justice ,&nbsp;Dakota J Batchek ,&nbsp;Susan Sumner ,&nbsp;Susan McRitchie ,&nbsp;John A. Batsis","doi":"10.1016/j.archger.2024.105685","DOIUrl":"10.1016/j.archger.2024.105685","url":null,"abstract":"<div><h3>Background</h3><div>Understanding how weight loss interventions in older adults with obesity impact aging biology can lay the foundation for targeted, ‘geroscience-based’ interventions. This study examines the association between changes in the senescence-associated secretory phenotypes (SASP) and changes in function in response to a weight loss intervention.</div></div><div><h3>Methods</h3><div>We conducted a post-hoc biomarker analysis on adults aged ≥ 65 years with body mass index [BMI] ≥30 kg/m² enrolled in a six-month, non-randomized telemedicine-delivered weight loss intervention. We assessed 16 SASP cytokines using serum samples collected pre-and post-intervention. Clinical outcomes include anthropometric and physical function measurements. A weight loss responder was defined as a loss of ≥5 % of body weight.</div></div><div><h3>Results</h3><div>Mean age was 73.2 ± 3.9 years (73 % female), and BMI was 36.5 ± 5.2 kg/m². Responders lost 7.6 ± 2.5 %, while non-responders lost 2.0 ± 2.3 % of weight (<em>n</em> = 16 per group, <em>p</em> &lt; 0.001). We observed several significant associations between SASP cytokines and physical function and anthropometric measurement outcomes in age- and sex-adjusted linear models. These included grip strength and Interleukin-8 (IL-8) (<em>b</em> = 9.07) and Insulin-like Growth Factor 1 (IGF-1) (<em>b</em> = 2.6); gait speed and Thymus and Activation-Regulated Chemokine (TARC) (<em>b</em> = 0.46) and IL-7(<em>b</em> = 61 0.11); weight IL-6 (<em>b</em> = -6.77) and IL-15 (<em>b</em> = -2.53); BMI and IL-15 (<em>b</em> = -0.95); waist-to-hip ratio and osteopontin (<em>b</em> = -0.07) (<em>p</em> &lt; 0.05 for all).</div></div><div><h3>Conclusions</h3><div>Our pilot data demonstrated an association between changes in select SASP biomarkers and increased functional ability with intentional weight loss in older adults with obesity. However, findings must be replicated in prospective randomized trials with a control group and additional SASP biomarkers.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105685"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambivalent ageism and the pains and gains of informal caregiving for older adults: Findings from Germany","authors":"Larissa Zwar,&nbsp;Hans-Helmut König,&nbsp;Emily Delfin,&nbsp;André Hajek","doi":"10.1016/j.archger.2024.105683","DOIUrl":"10.1016/j.archger.2024.105683","url":null,"abstract":"<div><h3>Background and objectives</h3><div>We analyzed the associations between ambivalent ageism, burden and positive experiences of care among informal caregivers of older adults (aged ≥60 years), to advance understanding of its role as psychosocial risk or resilience factor for informal caregivers.</div></div><div><h3>Design and methods</h3><div>Data of 433 informal caregivers (≥18 years) of adults with care needs (≥60 years) from the Attitudes towards Informal Caregivers (ATTIC) project was used. The Ambivalent Ageism Scale, Positive Aspects of Care Scale and the Burden Scale for Family Caregivers were used. Linear regression analyses adjusted for context and personal factors were conducted, with age and gender included as moderators in additional tests.</div></div><div><h3>Results</h3><div>High ageism (total score) was significantly associated with a high level of positive aspects of care and burden. Further analyses showed a significant positive association between benevolent ageism and positive aspects of care, while stronger hostile ageism was associated with less positive aspects of care. Hostile ageism was also significantly associated with more burden, while benevolent ageism and burden were not associated. Additional analyses indicated no moderation by gender, but by age. The association between hostile ageism and burden was weaker with caregivers’ higher age.</div></div><div><h3>Discussion and implications</h3><div>While hostile ageism and worse caregiver burden were associated, positive care experiences seemed to benefit from benevolent ageism. This highlights the complex associations between ageism and caregivers’ well-being, which need to be taken into account in theory and practice focused on improving the care situation for both caregivers and care recipients.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105683"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of obesity indices and their association with pain in community-dwelling older adults: Findings from the English longitudinal study of ageing","authors":"Shangmin Chen ,&nbsp;Mengzhen Min ,&nbsp;Lin Du ,&nbsp;Yongshan Gao ,&nbsp;Lei Xie ,&nbsp;Junjie Gao ,&nbsp;Liping Li ,&nbsp;Zhigang Zhong","doi":"10.1016/j.archger.2024.105690","DOIUrl":"10.1016/j.archger.2024.105690","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of pain has increased with the increase of obesity, and finding indicators to predict pain risk has become an urgent need. BMI, WC, and WHtR have the potential to be excellent predictors. However, the association of these obesity indicators with various pains remains unclear.</div></div><div><h3>Methods</h3><div>This longitudinal cohort study included 2155 pain-free participants (mean age = 68.5 years, standard deviation [SD] = 8.6) from the English Longitudinal Study of Ageing (ELSA). BMI, WC, and WHtR were measured during nurse visits at waves 0, 2, and 4. The Group-Based Trajectory Model (GBTM) was used to identify optimal trajectories for BMI, WC, and WHtR. Self-reported pain at four anatomical sites (lower back, hip, knee and total pain) was assessed at Waves 4 to 9. Cox proportional hazards models were employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between obesity indices and pain risk.</div></div><div><h3>Results</h3><div>Over a median follow-up period of 7.49 years, we observed 1,059 incident cases of all-cause pain. After adjusting for confounders, participants in the High-Stable WC group had a 30% higher risk of experiencing pain (HR: 1.30, 95 % CI: 1.05–1.60, <em>P</em> = 0.014), while those in the High-Stable WHtR group had a 29% higher risk (HR: 1.29, 95% CI: 1.06–1.56, <em>P</em> = 0.010) compared to the Low-Stable group. High-stable trajectories for BMI, WC, and WHtR were also associated with an elevated risk of back, hip, and knee pain.</div></div><div><h3>Conclusion</h3><div>This study identifies long-term obesity indices as significant predictors of pain, suggesting the importance of monitoring these measures for effective clinical risk assessments. Further research is needed to explore the underlying mechanisms of these associations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"129 ","pages":"Article 105690"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}