Archives of gerontology and geriatrics最新文献

{"title":"Geroprotective effect of Apigenin against skin senescence induced by an acute dose of gamma rays in male rats is associated with p-AMPK mediated autophagic flux","authors":"Mahmoud E. Habieb,&nbsp;Maha M. Ali,&nbsp;Thanaa M. Fahim,&nbsp;Fatma Y. Abdou","doi":"10.1016/j.archger.2026.106185","DOIUrl":"10.1016/j.archger.2026.106185","url":null,"abstract":"<div><div>One common side effect of radiotherapy is radiation-induced skin senescence. The current study is designed to explore the possible geroprotective effect of Apigenin (Api) against skin senescence induced by an acute dose of gamma rays in male rats. Thirty-two adult male rats were assigned into four groups: Control, γ-Radiation (6 Gy), Apigenin (50 mg/kg, orally), and Rad (6 Gy) + Api (50 mg/kg) for two weeks. Exposure to an acute dose of gamma radiation caused a significant increase in the levels of MDA and a significant decrease in GSH levels in comparison to control rats. Exposure to gamma radiation significantly increased skin collagen-1, p16^INK4a, and AGEs levels and upregulated γ-H2AX and P62 protein levels in comparison to the control. Moreover, gamma rays significantly reduced the skin content of MMP-1 and p-AMPK and downregulated LC3II/LC3I ratio protein expression compared to control rats. Microscopically, all the examined skin tissues of irradiated rats displayed deteriorated microarchitecture as well as lessened PCNA immunoexpression. Oral administration of Apigenin (50 mg/kg) to gamma-irradiated rats effectively alleviated all the tested parameters in skin tissues when compared to irradiated rats. Apigenin could effectively mitigate gamma radiation-induced damage of the skin of rats via its antioxidant effect and modulation of autophagy. Thus, the current findings support the radioprotective function of Apigenin by triggering autophagy and assisting in the removal of damaged cellular components. Apigenin could be a promising ameliorative remedy for skin protection against gamma irradiation.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"144 ","pages":"Article 106185"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and its dynamic change associate with risk of cardiovascular disease: Evidence from multinational prospective cohorts","authors":"Yanzhi Liu,&nbsp;Jinxi Wang,&nbsp;Xuemei Zhao,&nbsp;Xinqing Li,&nbsp;Chengyi Wang,&nbsp;Jiaying Yang,&nbsp;Huiqiao Han,&nbsp;Qiong Zhou,&nbsp;Yuhui Zhang","doi":"10.1016/j.archger.2026.106183","DOIUrl":"10.1016/j.archger.2026.106183","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease (CVD) is the leading cause of mortality and disability in aging populations. Intrinsic capacity (IC) is a novel measure related to health outcomes. However, most previous studies focused on baseline IC within individual cohorts. We investigated IC and its longitudinal changes in relation to CVD across three prospective cohorts.</div></div><div><h3>Methods</h3><div>Participants (over 45 years) were from China Health and Retirement Longitudinal Study (CHARLS), Health and Retirement Study (HRS), and English Longitudinal Study of Ageing (ELSA). IC was calculated as a composite score of locomotion, cognition, psychological well-being, sensory function, and vitality. IC change was assessed as tertile transition over four years and as longitudinal trajectories based on latent class mixed model. Incident CVD included angina, myocardial infarction, arrhythmia, heart failure, and stroke. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Analyses included 11,101, 6456, and 5761 participants from CHARLS, HRS, and ELSA for baseline IC; 7144, 4754, and 3979 for change-patterns; and 5428, 4754, and 2703 for trajectories. Higher IC was associated with lower CVD risk in all cohorts (CHARLS: HR 0.97, 95 % CI 0.97–0.98; HRS: HR 0.97, 95 % CI 0.96–0.97; ELSA: HR 0.98, 95 % CI 0.97–0.99). Among participants with low baseline IC, improvement to higher tertiles reduced risk. Compared with stable high-IC trajectory group, other groups showed higher risk.</div></div><div><h3>Conclusions</h3><div>Baseline IC, tertile change patterns, and trajectories are consistently associated with long-term CVD risk across nations. Lower IC, declining tertiles, and adverse trajectories increase risk, whereas higher IC and favorable changes are protective.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"144 ","pages":"Article 106183"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The growing burden of Alzheimer’s Disease and other dementias in China: Lessons for an aging society","authors":"Che Wang ,&nbsp;Tong Xin ,&nbsp;Wenting Zhong ,&nbsp;Qiong Tian ,&nbsp;Lihong Chen","doi":"10.1016/j.archger.2026.106165","DOIUrl":"10.1016/j.archger.2026.106165","url":null,"abstract":"<div><div>Alzheimer’s disease and other dementias (AD&amp;D) represent an escalating health and social challenge in China’s rapidly aging population. Using data from the Global Burden of Disease 2021 study, we observed substantial increases in incidence and prevalence over the past three decades, particularly among women and the oldest age groups. These trends underline the growing strain on family-based care systems and the urgent need for integrated, age-friendly health and social policies to address dementia in aging societies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"144 ","pages":"Article 106165"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146154188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life expectancy in stomach cancer survivors adjusted for blood-test-based frailty: insights into biological aging","authors":"Minh-Thao Tu ,&nbsp;Hoejun Kwon ,&nbsp;Bao-Yen Luong-Thanh ,&nbsp;Yoon-Jung Choi ,&nbsp;Bang Wool Eom ,&nbsp;Hyunsoon Cho","doi":"10.1016/j.archger.2026.106166","DOIUrl":"10.1016/j.archger.2026.106166","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is associated with biological aging, causing poor prognosis for cancer survivors, but has not been considered in life expectancy (LE) estimates. This study aims to estimate frailty-adjusted LE for patients aged ≥50 with stomach cancer, using routine blood tests.</div></div><div><h3>Methods</h3><div>We included 8,281 patients aged ≥50 diagnosed with stomach cancer in 2007-2018 at National Cancer Center (NCC), extracted from electronic health records. Frailty was assessed by 27 laboratory tests (FI-Lab) and classified as non-frail and frail. The impact of frailty on mortality was estimated by cause-specific Cox regression models with age as the timescale. The area under the survival curve was used to estimate the remaining LE adjusted for frailty.</div></div><div><h3>Results</h3><div>Frail patients (higher FI-Lab) had 1.4-fold higher risk of cancer and non-cancer mortality and shorter LE than non-frail patients (lower FI-Lab). Frailty affected 31.2% of middle-aged populations, leading to larger LE losses than in older groups. LE losses due to frailty for males at age 50 and 85 were 7.6 and 2.0 years, slightly higher than the losses in females (6.9 and 1.8 years, respectively). The mortality risk and LE loss due to frailty were largest in localized stage, at age 50: 3.9 years for males and 3.0 years for females, compared to &lt;2 years in regional stage and 0.5 years in distant stage for both sexes.</div></div><div><h3>Conclusions</h3><div>FI-Lab-defined frailty was associated with significant LE loss, particularly in male, middle-aged survivors with early-stage stomach cancer. By capturing early signs of biological aging, FI-Lab-based LE estimates may support clinical assessment and individualized survivorship care.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"144 ","pages":"Article 106166"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in spatial and temporal gait dynamics during aging: a narrative review on the role of the neural system","authors":"Christoph Centner ,&nbsp;Ramona Ritzmann ,&nbsp;Uros Marusic ,&nbsp;Luke Hughes","doi":"10.1016/j.archger.2026.106189","DOIUrl":"10.1016/j.archger.2026.106189","url":null,"abstract":"<div><div>Gait dynamics, encompassing both spatial and temporal parameters, undergo significant changes with aging, often leading to increased gait variability and, consequentially, a higher risk of falls. While cognitive and musculoskeletal factors have been demonstrated to contribute to these alterations, the role of the neural system is crucial and yet not fully understood. This review aims to synthesize the existing evidence on the age-related deterioration in locomotor functioning, with a specific emphasis on the neural mechanisms involved. Besides summarizing appropriate measures to quantify gait variability, several neural factors including cortical, neurotransmitter, and sensory system degeneration, are explored as key contributors to the observed changes in locomotion during aging. Additionally, the review discusses the potential use of diverse interventions to enhance gait variability during aging to reduce the risk of falls. By elucidating the complex interplay between aging, gait dynamics, and neural function, this review underscores the importance of targeted interventions aimed at preserving neural health to maintain gait stability and reduce fall risk in the aging population. The findings suggest that further research is needed to develop and refine strategies for the early detection and prevention of gait-related impairments linked to neural decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"144 ","pages":"Article 106189"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different non-pharmacological interventions on executive function in healthy older people: A systematic review and network meta-analysis","authors":"Ying Bai ,&nbsp;Yuan Yuan ,&nbsp;Bopeng Qiu ,&nbsp;Yong Yang ,&nbsp;Chen Cheng ,&nbsp;Junyu Wang ,&nbsp;Hao Liu ,&nbsp;Tao Wang ,&nbsp;Zhiyu Xiong ,&nbsp;Yiqi Li ,&nbsp;Zhongli Wang ,&nbsp;Lin Zhang","doi":"10.1016/j.archger.2026.106141","DOIUrl":"10.1016/j.archger.2026.106141","url":null,"abstract":"<div><h3>Objective</h3><div>Executive function (EF) is a critical component of healthy aging, and its decline represents a fundamental challenge to neurological health. This network meta-analysis (NMA) systematically compared and ranked the effects of a spectrum of non-pharmacological interventions on overall EF and its key subdomains—working memory, cognitive flexibility, and inhibition—in healthy older adults.</div></div><div><h3>Methods</h3><div>We searched PubMed, Cochrane, Embase, and Web of Science from their inception to February 17, 2025, for randomized controlled trials (RCTs) investigating non-pharmacological interventions in healthy older people (≥ 60 years). All analyses were performed using the R package “netmeta”. The risk of bias was assessed using the revised Cochrane Risk of Bias tool (RoB 2), and the confidence in the evidence was evaluated with the CINeMA (Confidence in Network Meta-Analysis) framework.</div></div><div><h3>Results</h3><div>A total of 115 RCTs with 16,824 healthy older people were included, evaluating 11 types of non-pharmacological interventions. Network meta-analysis revealed comparative effectiveness among the interventions: dance showed favorable outcomes for improving overall executive function (standardized mean difference [SMD] = 0.82, 95 % confidence interval [CI]: 0.40 to 1.24) and cognitive flexibility (SMD = 0.96, 95 % CI: 0.50 to 1.43). Resistance training was associated with greater improvement in working memory (SMD = 0.86, 95 % CI: 0.51 to 1.20), while computerized cognitive training showed a positive effect on inhibition (SMD = 0.48, 95 % CI: 0.28 to 0.68).</div></div><div><h3>Conclusions</h3><div>This network meta-analysis suggests that dance improves overall executive function and cognitive flexibility, resistance training enhances working memory, and computerized cognitive training benefits inhibition in healthy older adults. These findings offer an evidence-based ranking to inform the selection of targeted non-pharmacological interventions in clinical and community settings.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106141"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectedness matters more than feeling isolated: A 12-year longitudinal study of age-related decline in naming ability","authors":"Yanbing Hu ,&nbsp;Chenguang Du ,&nbsp;Xiaofeng Ma","doi":"10.1016/j.archger.2025.106126","DOIUrl":"10.1016/j.archger.2025.106126","url":null,"abstract":"<div><div>Naming ability supports effective communication and functional independence in late life, yet it declines variably. Psychosocial factors like loneliness may exacerbate this trajectory, yet research often treats loneliness as a unitary construct. This study examined whether overall loneliness and its subdimensions, subjective isolation and structural lack of connections, differentially predict naming trajectories, and whether naming and social connectedness are bidirectionally related. Using four biennial waves of Health and Retirement Study data (2008–2020; <em>N</em> = 3504), we applied hierarchical linear models to analyze trajectories and cross-lagged panel models to test directionality, adjusting for demographics, health, and family factors. Greater overall loneliness predicted faster naming decline. Crucially, decomposing loneliness revealed that the lack of available social connections, a structural dimension, robustly predicted decline even after rigorous adjustment, whereas subjective isolation did not predict decline when covariates were included. Cross-lagged effects were small and stage-specific, showing that naming ability predicted later connectedness (in early and late stages) and that connectedness predicted later naming performance (in the mid-stage). These findings highlight that structural connectedness, defined as the actual availability of a social network, is more critical for preserving linguistic function than the mere feeling of isolation. Furthermore, the link between language and connection is dynamic and mutually reinforcing. Interventions should therefore prioritize maintaining social engagement and providing communication support, targeting structural connectedness as a modifiable factor to preserve language and cognitive health in aging populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106126"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: “Ageism and the feminization of old age: A systematic review”","authors":"Fatma Ozge Kayhan Kocak ,&nbsp;Elif Gungor Genc","doi":"10.1016/j.archger.2026.106164","DOIUrl":"10.1016/j.archger.2026.106164","url":null,"abstract":"<div><div>This is a Letter to the Editor and does not include an abstract Highlights Gendered late-life vulnerabilities reflect cumulative life-course disadvantage Social isolation shows distinct mental health pathways for women and men Older women show higher depression risk; older men higher suicide risk·Clinical observations reinforce review-based policy implications.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106164"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tongue strength and cognitive decline in older adults: A scoping review","authors":"Getachew Yideg Yitbarek ,&nbsp;Jane Alty ,&nbsp;Eddy Roccati ,&nbsp;Katherine Lawler ,&nbsp;Lynette R. Goldberg","doi":"10.1016/j.archger.2026.106146","DOIUrl":"10.1016/j.archger.2026.106146","url":null,"abstract":"<div><h3>Objective</h3><div>There is a need to identify non-invasive, accessible biomarkers of cognitive decline and dementia risk. Frailty, sarcopenia and poor nutritional health are known to increase the risk of cognitive impairment and decreased tongue strength is a key component of all these. It remains unclear, though, if tongue strength holds potential as a non-invasive biomarker of cognitive decline. This scoping review mapped evidence from adults ≥50 years of age to document associations between tongue strength and cognitive decline, as well as the known risk factors of frailty, sarcopenia, and poor nutritional health.</div></div><div><h3>Methods</h3><div>The JBI scoping review methodology and the PRISMA-ScR guided the review process. Six databases were searched: PubMed, PsycINFO (Ovid), Scopus, Embase (Ovid), CINAHL, and Web of Science.</div></div><div><h3>Results</h3><div>Of 3409 records identified, 59 studies with 27,073 participants met eligibility criteria; these were published between 2011 and 2024, with 45 studies cross-sectional and 14 longitudinal, including two RCTs. Although measurement methods varied across the studies, there was evidence that decreased tongue strength in older adults was associated with cognitive decline (including Mild Cognitive Impairment and dementia), physical frailty, sarcopenia, and poorer nutritional health.</div></div><div><h3>Conclusions</h3><div>Tongue strength holds promise as a new biomarker of cognitive decline and dementia risk. Effective interventions exist to strengthen the tongue. This further supports the importance of measuring tongue strength to optimise older adults’ health and cognitive function. Further culturally diverse, longitudinal studies are needed to validate the observed associations and establish specific tongue strength cutoff values to determine stages of cognitive decline.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106146"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric transition care between acute hospital and residential healthcare settings: scoping review of current models and proposed conceptual framework","authors":"Emanuele Rossi ,&nbsp;Flavia Di Lorenzo ,&nbsp;Renato Congedo ,&nbsp;Donatella D’Accolti","doi":"10.1016/j.archger.2026.106160","DOIUrl":"10.1016/j.archger.2026.106160","url":null,"abstract":"<div><h3>Background</h3><div>Population ageing and the increasing complexity of care pathways make transitions from hospital to residential healthcare facilities a critical phase for continuity of care. Inadequate management may result in clinical errors, repeated hospitalisations, and increased healthcare costs. The lack of standardised models and limited understanding of transitional care pathways highlight the need for further investigation of existing approaches.</div></div><div><h3>Objectives</h3><div>This scoping review aims to identify and map geriatric transitional care models described in the literature, focusing on their main characteristics, the professionals involved, and their potential applicability within the Italian National Health Service.</div></div><div><h3>Methods</h3><div>A scoping review was conducted according to the guidelines of the Joanna Briggs Institute and Prisma-ScR. The bibliographic search, carried out on Medline, ScienceDirect and Web of Science, identified 2107 articles. After removing duplicates and screening against predefined inclusion and exclusion criteria, seven studies were included.</div></div><div><h3>Results</h3><div>Across the seven studies, twelve transitional care projects were identified. Most models adopted a multidisciplinary, nurse-centred approach with active involvement of patients and family caregivers. Advanced Practice Nurses or equivalent expert nurses played a central role in care coordination, medication reconciliation, and post-discharge follow-up, contributing to reduced hospital readmissions and improved patient satisfaction.</div></div><div><h3>Conclusions</h3><div>Existing models suggest that multidisciplinary transitional care, supported by expert nurses, can enhance continuity and quality of care for older adults transferred to residential facilities. The conceptual framework derived from this mapping should be interpreted as a hypothesis‑generating synthesis to guide local adaptation and piloting in Italy, particularly by strengthening the role and competencies of Family and Community Nurses.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106160"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}