Archives of gerontology and geriatrics最新文献

{"title":"Communication challenges and response strategies of late-deafened older adults","authors":"Gianna Kohl,&nbsp;Erin M. Heniff,&nbsp;Maya E. Dye,&nbsp;Wendy A. Rogers","doi":"10.1016/j.archger.2025.105821","DOIUrl":"10.1016/j.archger.2025.105821","url":null,"abstract":"<div><h3>Background</h3><div>A growing number of adults are aging with hearing impairments. Late-deafened individuals, who experience severe to profound hearing loss after acquiring spoken language, often face unique communication challenges in everyday activities. Despite these difficulties, little is known about the specific activities and contexts where they occur.</div></div><div><h3>Objectives</h3><div>To identify activities that present communication challenges for late-deafened older adults and to explore the response strategies they adopt to manage these challenges.</div></div><div><h3>Methods</h3><div>The Aging Concerns, Challenges, and Everyday Solution Strategies (ACCESS) study uses a mixed-methods approach to explore the daily challenges faced by individuals aging with long-term disabilities. Sixty participants (66.7 % female; M age = 69.3, <em>SD</em> = 6.0) with severe to profound bilateral hearing loss for at least ten years completed questionnaires and structured interviews. Qualitative data were analyzed using content analysis.</div></div><div><h3>Results</h3><div>The content analysis revealed communication challenges with healthcare appointments, entertainment events, interactions with unfamiliar people, and group activities. Specific difficulties included general hearing impairments, challenging listening environments, limitations of assistive technologies, reliance on auditory stimuli, and insufficient social support. To manage these challenges, participants employed various strategies, including the use of assistive technologies, personal amplification devices, communication repair techniques, adaptive communication methods, and disclosing their hearing status.</div></div><div><h3>Conclusions</h3><div>The findings highlight the diverse range of communication challenges faced by late-deafened older adults. The identified strategies illustrated their resilience and adaptability but also underscored areas for improvement. Enhanced assistive technologies, better environmental accommodations, and supportive policies are essential to address these challenges effectively.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105821"},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness analysis of tube feeding among older adults with advanced dementia in Japan: A net benefit regression approach","authors":"Ning Liu ,&nbsp;Akira Babazono ,&nbsp;Kenshi Hayashida ,&nbsp;Aziz Jamal ,&nbsp;Reiko Ishihara ,&nbsp;Reiko Yamao ,&nbsp;Shinichiro Yoshida ,&nbsp;Shinya Matsuda ,&nbsp;Yunfei Li","doi":"10.1016/j.archger.2025.105812","DOIUrl":"10.1016/j.archger.2025.105812","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to assess the cost-effectiveness of percutaneous endoscopic gastrostomy (PEG) and nasogastric tube (NGT) in older adults with advanced dementia, compared with non-artificial nutrition.</div></div><div><h3>Methods</h3><div>Retrospective cohort study. Medical claims data and long-term care claims data from Fukuoka Prefecture, Japan, were used. We identified 3,882 older adults (≥75 years) with advanced dementia who were hospitalized between April 2016 and March 2019 due to dysphagia, malnutrition, or aspiration pneumonia. Using propensity score matching, we matched 192 patients in the PEG group with 192 in the non-artificial nutrition group, and 490 patients in the NGT group with 490 in the non-artificial nutrition group. We examined the survival years and total costs of each patient from the date of admission to March 31, 2020, and thereby estimated the cost-effectiveness of PEG and NGT, respectively, versus non-artificial nutrition. The net benefit regression model was employed to estimate the incremental net benefits (INB) with varying values of willingness-to-pay (WTP) for PEG and NGT. Furthermore, cost-effectiveness acceptability curve was used to present the probability of the cost-effectiveness of each intervention.</div></div><div><h3>Results</h3><div>As WTP increased from JPY 7,747,909 (equivalent to US$51,546) to JPY 28,163,651 (equivalent to US$187,371), the probability of PEG being cost-effective increased from 50 % to nearly100 %. The NGT group had negative INB estimates.</div></div><div><h3>Conclusions</h3><div>Both PEG and NGT are less likely to provide economic values for patients with advanced dementia. However, this conclusion should be further refined through detailed cost-effectiveness analysis from multiple perspectives.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105812"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the triglyceride-glucose index on non-alcoholic fatty liver disease: Causal evidence from longitudinal cohort studies","authors":"Tengrui Cao ,&nbsp;Xuetong Ni ,&nbsp;Aheyeerke Halengbieke ,&nbsp;Jianmin Tang ,&nbsp;Yumei Han ,&nbsp;Feng Sun ,&nbsp;Bo Gao ,&nbsp;Deqiang Zheng ,&nbsp;Yuxiang Yan ,&nbsp;Xinghua Yang","doi":"10.1016/j.archger.2025.105813","DOIUrl":"10.1016/j.archger.2025.105813","url":null,"abstract":"<div><h3>Background</h3><div>Insulin resistance (IR) is strongly related to non-alcoholic fatty liver disease (NAFLD). Triglyceride-glucose (TyG) index serves as a novel substitute indicator for IR. However, research on the effect of TyG index on NAFLD remains sparse. This study aims to investigate the causal association between TyG index and incident NAFLD.</div></div><div><h3>Methods</h3><div>The primary cohort consisted of 27,052 participants from the Beijing Health Management Cohort, while the external validation cohort included 75,023 participants from the Taiwan MJ Cohort. Entropy balancing for continuous treatments (EBCT) combined with logistic regression and targeted maximum likelihood estimation (TMLE) were used to evaluate the causal association between the TyG index and incident NAFLD.</div></div><div><h3>Results</h3><div>During a median follow-up of 2.49 years in the primary cohort, 6,168 participants (median age: 36.0 years) developed incident NAFLD. EBCT combined with logistic regression revealed the odds ratio (95 % CI) of NAFLD risk was 1.742 (1.478–2.054) for each 1-unit increase in the baseline TyG index. In the TMLE model, the risk ratio (95 % CI) for NAFLD was 1.540 (1.406–1.687) in the Q4 (quartile 4) group compared with the Q1 group. These findings were consistent with those from the external validation cohort, reinforcing the robustness of the causal relationship between the TyG index and NAFLD incidence.</div></div><div><h3>Conclusions</h3><div>The advanced double-robust estimation method suggests that a higher baseline TyG index may be causally associated with an increased NAFLD risk, providing more reliable evidence for its role as a simple biomarker and demonstrating the utility of double-robust estimation causal inference models in epidemiology.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105813"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter 2 inhibitors in the treatment of heart failure patients: A systematic review and meta-analysis of cost-utility studies","authors":"Xinyue Zhang ,&nbsp;Yanxia Zhang ,&nbsp;Jiayu Wang ,&nbsp;Zhijia Tang","doi":"10.1016/j.archger.2025.105809","DOIUrl":"10.1016/j.archger.2025.105809","url":null,"abstract":"<div><h3>Aims</h3><div>Sodium–glucose cotransporter-2 inhibitors (SGLT-2i) have shown promise in reducing cardiovascular mortality and hospitalization due to heart failure (HF), a significant global health issue. This study aims to evaluate the incremental net benefit (INB) of SGLT-2i in HF patients through a systematic review and meta-analysis of cost-utility studies.</div></div><div><h3>Methods</h3><div>We searched five databases from their inception until Aug 30, 2024, economic evolution studies reporting cost-effectiveness and cost-utility analyses comparing SGLT-2i combined with standard triple-therapy versus standard triple-therapy alone in HF patients were selected. INB as the primary outcome was calculated in monetary units adjusted for purchasing power parity in 2022 US dollars.</div></div><div><h3>Results</h3><div>This review included 46 studies, with 41 studies (55 comparisons) pooled into meta-analysis. Adding SGLT2is was cost-effective compared to standard triple-therapy alone, from both healthcare system perspective (INB, $4042.08; 95 % CI, $1758.70-$6325.46) and payer perspective (INB, $12,972.84; 95 % CI, $4711.5-$21,234.22). However, subgroup analyses showed non-significant economic benefit in HF patients with preserved ejection fraction (HFpEF) both from the healthcare system perspective (INB, -$639.32; 95 % CI, -$1850.09-$571.44) and the payer perspective (INB, $3611.07; 95 % CI, -$208.49-$7430.64). Additionally, HF patients from low- and middle-income countries did not show significant economic benefit from the payer perspective (INB, $55,645.70; 95 % CI, -$51,000.00-$160,000.00).</div></div><div><h3>Conclusions</h3><div>The findings suggest that adding SGLT-2i is cost-effective compared to conventional standard triple-therapy alone, from both healthcare system and payer perspectives. Nevertheless, the economic benefits are limited in HFpEF and those from low- and middle-income countries. Further research is needed to explore the cost-effectiveness from a broader societal perspective.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105809"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies","authors":"Yajing Gao ,&nbsp;Yuli Huang ,&nbsp;Ran An,&nbsp;Yi Yang,&nbsp;Xinyao Chen,&nbsp;Qiaoqin Wan","doi":"10.1016/j.archger.2025.105807","DOIUrl":"10.1016/j.archger.2025.105807","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is generally an age-related condition in older people that impacts adverse health consequences in terms of quality of life, morbidity and mortality. With the increasing interest of clinical and research interest in sarcopenia internationally, the epidemiological evidence reveals sarcopenia risk begins in early adulthood, influenced by gene, lifestyle and a range of chronic conditions across life course.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to systematically summarize the risk factors for sarcopenia across the life course, and to identity the high-risk population.</div></div><div><h3>Methods</h3><div>Searches were performed in PubMed, Web of Science, Scopus, Embase, MEDLINE, and SPORTDiscus databases from inception to July 2024. Longitudinal studies assessing the risk factors for sarcopenia in community setting were included in the analysis. Fixed- and random-effect models were used to pool effect size. Based on the results of meta-analysis, we developed a risk predictive model for sarcopenia.</div></div><div><h3>Results</h3><div>Fifty-three studies were included in our systematic review. Risk factors associating with sarcopenia were grouped into eight domains: sociodemographic, anthropometric, health behaviors, health condition, biomarkers, early life factors, psychosocial and living environment factors. Fifteen risk factors derived from the twenty-three included studies were eligible for meta-analysis, and ten variables were identified as statistically significant. A risk predictive model was developed for secondary sarcopenia in community setting.</div></div><div><h3>Conclusions</h3><div>This study provides a fully understanding of sarcopenia across the life-course. Our risk predictive model could facilitate the early identification and prevention of secondary sarcopenia in community setting.</div></div><div><h3>Registration</h3><div>The systematic review and meta-analysis have been registered in PROSPERO(CRD42024536346)</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105807"},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of DNA methylation-based epigenetic age acceleration with facial expression recognition in older adults","authors":"Da-eun Lee ,&nbsp;Yinan Zheng ,&nbsp;Kyoung-Bok Min ,&nbsp;Brian Joyce ,&nbsp;Jun Wang ,&nbsp;Tao Gao ,&nbsp;Lifang Hou ,&nbsp;Sang-Won Ha ,&nbsp;Da-Eun Jeong ,&nbsp;Min-Ju Kang ,&nbsp;Jin-Young Min ,&nbsp;Kyeezu Kim","doi":"10.1016/j.archger.2025.105808","DOIUrl":"10.1016/j.archger.2025.105808","url":null,"abstract":"<div><h3>Background</h3><div>Facial expression recognition (FER) abilities play a crucial role in fostering beneficial social relationships for healthy aging, however, these abilities tend to decline as people age. We investigated the association between epigenetic age acceleration (EAA) and FER among older individuals.</div></div><div><h3>Methods</h3><div>Accuracy rates and response times for six emotions, anger, disgust, fear, happiness, sadness, and surprise, were assessed in outpatients who visited the Veterans Health Service Medical Center. We calculated six EAA measures (intrinsic EAA, extrinsic EAA, PhenoAge acceleration, GrimaAge2 acceleration, skin and blood Age Acceleration, and Dunedin Pace of Aging Calculated from the Epigenome), based on DNA methylation levels across 935,000 CpGs. We employed multiple linear regression models adjusting for demographic and socioeconomic variables.</div></div><div><h3>Results</h3><div>In men, EAA was associated with a lower accuracy rate for fear (DunedinPACE: β= -7.53, 95 % CI= -12.12, -2.95) and a higher rate for sadness (Grim2AA: β= 5.44, 95 % CI= 0.37, 10.51). In women, EAA was associated with a lower accuracy rate for anger (SBAA: β= -5.06, 95 % CI= -9.43, -0.70) and a higher rate for happiness (EEAA: β= 4.79, 95 % CI= 0.85, 8.73). In men, EAA had an association with a faster response for fear (EEAA: β= -0.24, 95 % CI= -0.44, -0.05) and in women, for all emotions except sadness.</div></div><div><h3>Conclusions</h3><div>Greater EAA was associated with higher accuracy rates in recognizing happiness among women and sadness among men. Our findings suggest that biological aging may enhance recognition of positive emotions and empathy for others' sadness, rather than simply reducing FER abilities.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105808"},"PeriodicalIF":3.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction as a biomarker of frailty: The FRAMITO study protocol","authors":"Edoardo Locatelli ,&nbsp;Barbara Torsello ,&nbsp;Sofia De Marco ,&nbsp;Martina Lombardi ,&nbsp;Francesca Remelli ,&nbsp;Giulia Pampolini ,&nbsp;Elena Ferrighi ,&nbsp;Marialucia Bursi ,&nbsp;Andrea Bellotti ,&nbsp;Valentina Pasquale ,&nbsp;Giacomo Ducci ,&nbsp;Ouldouz Navaei ,&nbsp;Raffaella Candeloro ,&nbsp;Maria Cristina Ferrara ,&nbsp;Wenxiang Guo ,&nbsp;Eleonora Cucini ,&nbsp;Giuseppe Bellelli ,&nbsp;Massimiliano Castellazzi ,&nbsp;Elena Sacco ,&nbsp;Giuseppe Paglia ,&nbsp;Caterina Trevisan","doi":"10.1016/j.archger.2025.105803","DOIUrl":"10.1016/j.archger.2025.105803","url":null,"abstract":"<div><div>Frailty syndrome often coexists with multimorbidity, sharing several risk factors and outcomes. Therefore, considering multimorbidity when exploring frailty biomarkers may deepen our understanding of these conditions’ pathophysiology. In this regard, most studies focused on inflammation, but markers of mitochondrial dysfunction, such as mitochondrial DNA damage, cell respiratory impairment, and oxidative stress, are less explored. The FRAMITO project aims to evaluate mitochondrial dysfunction in frailty, with and without multimorbidity. This cross-sectional study will enroll 75 individuals aged ≥65 years from inpatient and outpatient clinics at the Geriatrics Units of the University Hospital of Ferrara (Ferrara, Italy) and Fondazione IRCCS San Gerardo dei Tintori (Monza, Italy). Participants will be categorized into three groups: 25 without frailty and multimorbidity, 25 with frailty but not multimorbidity, and 25 with frailty and multimorbidity. Blood samples will be collected to isolate Peripheral Blood Mononuclear Cells. Frailty biomarkers will be identified using untargeted metabolomics and functional studies on mitochondrial dysfunctions in PBMCs and their subpopulations, evaluating mitochondrial DNA damage, mitochondrial and glycolytic cellular bioenergetics, and intracellular reactive oxygen species. This project will advance our understanding of mitochondrial dysfunctions in frailty, particularly when combined with multimorbidity, revealing potential synergistic effects.</div></div><div><h3>Clinicaltrial.gov registration number</h3><div>NCT06433427.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105803"},"PeriodicalIF":3.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global challenge of multimorbidity in an aging world","authors":"Liang-Kung Chen","doi":"10.1016/j.archger.2025.105804","DOIUrl":"10.1016/j.archger.2025.105804","url":null,"abstract":"","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"132 ","pages":"Article 105804"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of protein intake with the risk of fractures: A prospective cohort study of UK biobank participants","authors":"Haohan Yang ,&nbsp;Yu Jiang ,&nbsp;Yan Luo ,&nbsp;Kaihua Qin ,&nbsp;Chang Yang ,&nbsp;Dingfa Liang ,&nbsp;Yong Xie ,&nbsp;Xiang Cui ,&nbsp;Wen Ju ,&nbsp;Peifu Tang ,&nbsp;Licheng Zhang ,&nbsp;Houchen Lyu","doi":"10.1016/j.archger.2025.105805","DOIUrl":"10.1016/j.archger.2025.105805","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the associations between protein intake and fractures risk in a large population-based cohort.</div></div><div><h3>Methods</h3><div>We conducted a prospective population-based study of UK Biobank. Participants aged 40–69 who completed the Oxford WebQ dietary questionnaire at least once were included. Exposures were percentage of energy provided by protein and its components (animal and vegetable protein). Participants were categorized into quintiles based on these exposures. The primary outcome was composite fracture, and secondary outcomes included osteoporotic and hip fractures, defined by ICD-10 codes. We used Cox proportional hazard models and restricted cubic splines (RCS) to assess the association between exposure and outcomes, as well as their dose-response relationships.</div></div><div><h3>Results</h3><div>This study included 132,807 participants (mean [SD] age, 56.8 [8.0] years; 68,769 [51.8 %] female). During a median follow-up of 12.4 years, 6,673 composite fractures, 4,496 osteoporotic fractures and 930 hip fractures occurred. Regarding protein intake, compared to the lowest quintile (Q1), individuals in the highest quintile (Q5) had significantly lower risks of composite fracture (HR 0.82, 95 % CI 0.75–0.90), osteoporotic fracture (HR 0.81, 95 % CI 0.72–0.91) and hip fracture (HR 0.63, 95 % CI 0.49–0.82). Similar results were observed for animal and vegetable protein intake. RCS revealed a negative linear dose-response relationship between protein intake and fractures risk.</div></div><div><h3>Conclusion</h3><div>Increased protein intake can significantly reduce the risk of fractures and may serve as an important dietary strategy for promoting bone health.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105805"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The connection between 91 inflammatory cytokines and frailty mediated by 1400 metabolites: An exploratory two-step Mendelian randomization analysis","authors":"Bo Wen ,&nbsp;Shizhuang Wei ,&nbsp;Daolai Huang ,&nbsp;Chao Zhang ,&nbsp;Hua Wang ,&nbsp;Sisi Liu ,&nbsp;Xianghua Wu","doi":"10.1016/j.archger.2025.105774","DOIUrl":"10.1016/j.archger.2025.105774","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, a common, multifaceted, and significant geriatric condition, involves crucial roles of inflammation and metabolic factors in its onset and progression. Nevertheless, the ambiguities and complexities in earlier observational studies make current research into their interactions somewhat insufficient. Our goals were to clarify the causal link between inflammatory cytokines and frailty and to explore the potential mediating effect of metabolites using Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Utilizing detailed summary-level data from genome-wide association studies, we conducted two-sample Mendelian randomization analyses to evaluate the potential causal connection between 91 inflammatory cytokines and the frailty index, along with the possible mediating pathways that involve 1400 metabolites. For our main analysis, we applied the inverse variance weighted method. To evaluate the potential mediating pathways of metabolites, a two-step MR analysis was utilized.</div></div><div><h3>Results</h3><div>We identified 8 inflammatory cytokines that were genetically associated with the frailty index, we subsequently identified 2 mediated relationships, with 2 metabolites acting as potential mediators between 2 inflammatory cytokines and frailty index. The 8 inflammatory cytokines were fractalkine (CX3CL1), interleukin-33 (IL-33), leukemia inhibitory factor receptor (LIF-R), monocyte chemoattractant protein-1 (CCL8), C<img>C motif chemokine 4 (CCL4), C-X-C motif chemokine 10 (CXCL10), fibroblast growth factor 5 (FGF-5), and TNF-beta (TNFB) levels.</div></div><div><h3>Conclusions</h3><div>The findings of this study demonstrate a direct connection between inflammatory cytokines and the frailty index, as well as two pathways mediated by metabolites. These biomarkers contribute valuable insights into the foundational mechanisms of frailty, presenting a novel research avenue for upcoming clinical studies.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"133 ","pages":"Article 105774"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}