Archives of gerontology and geriatrics最新文献

{"title":"Causal relationships between micronutrients and sarcopenia: a two-sample bidirectional Mendelian randomization study","authors":"Huilin Liu ,&nbsp;Jiahui Chen ,&nbsp;Shihao Ni ,&nbsp;Wenjie Long ,&nbsp;Xiaoming Dong ,&nbsp;Huili Liao ,&nbsp;Lu Lu ,&nbsp;Zhongqi Yang","doi":"10.1016/j.archger.2025.105917","DOIUrl":"10.1016/j.archger.2025.105917","url":null,"abstract":"<div><div>Sarcopenia, a geriatric syndrome in older adults, significantly impacts quality of life and elevates health risks. This study examines the causal relationships between specific micronutrients—magnesium, selenium, calcium, zinc, iron, phosphorus, and omega-3 fatty acids—and sarcopenia-related traits (SP-traits) using Mendelian randomization (MR) based on genome-wide association studies (GWAS). A bidirectional two-sample MR analysis was performed using data from fourteen GWAS, focusing on five SP-traits: low hand grip strength, moderate-to-vigorous physical activity (MVPA), ability to walk or cycle unaided for 10 min (AWCU10), usual walking pace, and adjusted appendicular lean mass (ALM). The analysis identified 14 single nucleotide polymorphisms (SNPs) linked to zinc levels and MVPA, and 12 SNPs associated with usual walking pace. Concerning ALM, 72 SNPs were associated with magnesium and 81 with omega-3 fatty acids. Significant associations were noted between zinc levels and MVPA (beta = 0.85, <em>P</em> = 0.026) and usual walking pace (beta = 0.53, <em>P</em> = 0.008). The reverse MR analysis revealed a positive correlation between ALM and magnesium (beta = 0.126, <em>P</em> = 0.0004) and a nominally significant negative correlation with omega-3 (beta = -0.083, <em>P</em> = 0.008). While some heterogeneity was noted, no pleiotropy was detected, reinforcing the robustness of the findings. This study highlights the importance of magnesium, zinc, and omega-3 fatty acids in muscle health and advocates for their inclusion in public health strategies to enhance the physical function and quality of life in older adults. Further research is needed to validate these findings across diverse populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105917"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort study","authors":"Mamoru Sato ,&nbsp;Manami Hoshi-Harada ,&nbsp;Kenji Takeuchi ,&nbsp;Taro Kusama ,&nbsp;Takaaki Ikeda ,&nbsp;Sakura Kiuchi ,&nbsp;Masashige Saito ,&nbsp;Naoki Nakaya ,&nbsp;Ken Osaka","doi":"10.1016/j.archger.2025.105914","DOIUrl":"10.1016/j.archger.2025.105914","url":null,"abstract":"<div><h3>Objectives</h3><div>Social isolation and loneliness each have negatively affect various health outcomes. No studies have examined the combined association of social isolation and loneliness on frailty onset. This study aimed to investigate both the objective and subjective aspects of isolation by evaluating social isolation and loneliness and to determine their interaction effects on frailty onset.</div></div><div><h3>Methods</h3><div>This cohort study used data from the 2019 and 2022 Japan Gerontological Evaluation Study. The eligible participants were independent older adults aged ≥65 years without frailty in 2019. The outcome variable was frailty onset in 2022. The exposure variables were social isolation and loneliness in 2019. Risk ratios (RR) and 95 % confidence intervals (CI) were estimated using modified Poisson regression models, with potential confounders as covariates. Moreover, a multiplicative scale and relative excess risk due to interaction (RERI) was used to assess the interaction.</div></div><div><h3>Results</h3><div>The analysis included 8440 participants (mean age: 73.2 [standard deviation, 5.5] years). During the follow-up, 15.1 % of participants experienced frailty onset. After adjusting for all covariates, the “severe isolation” &amp; “severe loneliness” group had the highest risk of frailty onset (RR = 2.09 [95 % CI: 1.60–2.73]) compared to “no isolation” &amp; “no loneliness” group. However, there were no significant multiplicative and additive interaction between social isolation and loneliness on frailty onset (multiplicative scale: 0.75 [95 % CI: 0.50–1.11]; RERI:0.29 [95 % CI:1.02–0.44]).</div></div><div><h3>Discussion</h3><div>These findings highlight the importance of considering social factors such as interaction with others and loneliness, to prevent frailty.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105914"},"PeriodicalIF":3.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in the association between internet use and dementia among older adults: A machine-learning analysis","authors":"Atsushi Nakagomi ,&nbsp;Katsunori Kondo ,&nbsp;Koichiro Shiba","doi":"10.1016/j.archger.2025.105912","DOIUrl":"10.1016/j.archger.2025.105912","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Internet use among older adults may reduce the risk of dementia, but it remains unknown how the effects vary across individuals. The aim of this study was to rigorously examine heterogeneity in the association between internet use and dementia among older adults with a machine learning approach.</div></div><div><h3>Methods</h3><div>This cohort study used data from the Japan Gerontological Evaluation Study involving functionally independent adults aged 65 or older (n = 5,451). The exposure, internet use a few times a month or more often, was assessed with the 2016 survey (baseline) and covariates (potential confounders and effect modifiers) were assessed with the 2013 survey (pre-baseline). Follow-up continued until 2022, identifying 5.5-year dementia onset (n = 549) using the public long-term care insurance system. Using the generalized random forest algorithm, we estimated how the association between internet use and dementia onset during a 5.5-year follow-up period varies by pre-baseline sociodemographic characteristics and health conditions.</div></div><div><h3>Results</h3><div>Internet use was on average associated with a lower risk of dementia (estimated population average effect = -0.033; 95 % CI: -0.051, -0.016). However, we found evidence of between-individual heterogeneity in this association, where internet use appeared more beneficial among individuals who reported middle income, higher education levels, and were socially and physically inactive at the pre-baseline wave.</div></div><div><h3>Conclusions</h3><div>Internet use may disproportionately benefit people based on socioeconomic status, suggesting equity concerns of universal implementation. Understanding such effect heterogeneity can inform more targeted public health interventions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105912"},"PeriodicalIF":3.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial performance of people with acquired cognitive impairments or affective disturbances – A prospective, European-wide study","authors":"Ting Jiang,&nbsp;Geraldina F. Gaastra,&nbsp;Janneke Koerts","doi":"10.1016/j.archger.2025.105911","DOIUrl":"10.1016/j.archger.2025.105911","url":null,"abstract":"<div><h3>Background</h3><div>Financial capability, encompassing both financial competence and financial performance, is essential for independent living. However, individuals with neurological and psychiatric disorders often demonstrate difficulties with financial capability. This study examined the influence of common neurological and psychiatric conditions, i.e., Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and affective disturbances, on financial performance.</div></div><div><h3>Methods</h3><div>Prospective data from wave 8 (<em>n</em>= 53,695) and wave 9 (<em>n</em>= 69,477) of the Survey of Health, Retirement and Ageing in Europe were used, which included individuals aged 50+; part of Wave 8 and all of Wave 9 data were collected during the COVID-19 pandemic. Logistic regressions and group comparisons were conducted to analyze the influence of self-reported disease diagnosis on three aspects of (future) financial performance: difficulties in managing money, difficulties in making ends meet, and debt situation.</div></div><div><h3>Results</h3><div>Compared to controls, participants with one of the four conditions reported significantly more often having difficulties managing money. Within the AD group, over half of the participants reported these difficulties. The different diagnoses also predicted both current and future difficulties in managing money and making ends meet. However, only affective disorders were associated with and predicted a higher likelihood of having household debts.</div></div><div><h3>Discussion and Implications</h3><div>Compared to controls, individuals with PD, AD, stroke, or affective disorders are more prone to experiencing impairments with both current and future financial performance, potentially facing financial difficulties. These results emphasize the importance of recognizing financial difficulties in such individuals and offering financial assistance when needed.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105911"},"PeriodicalIF":3.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of the built environment and perceived neighborhood on physical frailty and sarcopenia in older adults: A systematic review","authors":"Lucas dos Santos Ferreira ,&nbsp;Thais Evelin Marques da Silva ,&nbsp;Eliziane Batista dos Santos ,&nbsp;Felipe Fank ,&nbsp;João Araújo Barros Neto ,&nbsp;Enaiane Cristina Menezes","doi":"10.1016/j.archger.2025.105910","DOIUrl":"10.1016/j.archger.2025.105910","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the scientific evidence on the relationship between the built environment, perceived neighborhood, and physical frailty and sarcopenia in older adults.</div></div><div><h3>Methods</h3><div>The search used PUBMED, SCOPUS, EMBASE, Web of Science, Scielo databases, and Google Scholar as gray literature. Studies with non-institutionalized older adults aged 60 years or older that tested the relationship with the perceived neighborhood and built environment and with physical frailty or sarcopenia, as well as observational studies published in English, Portuguese, and Spanish, were included.</div></div><div><h3>Results</h3><div>18 studies were included in the qualitative synthesis (<em>n</em> = 102.789 older adults). Three studies evaluated the relationship between the built environment and perceived neighborhood and sarcopenia, and 15 studies with physical frailty. Regarding the study design, five studies were cohort, and 13 were cross-sectional. The results found that lack of access to public transportation, poor access to recreational facilities, absence of destination, hazard hills, and absence of traffic safety were risk factors for sarcopenia. Walkability, safety from crime, recreational facilities/walking and cycling facilities/exercise facilities and neighborhood aesthetics, were environmental characteristics that showed associations with physical frailty. After sensitivity analysis, walkability was shown to be inconclusive.</div></div><div><h3>Conclusion</h3><div>Evidence indicates that older adults who live in built environments with higher walkability, access to recreational facilities/walking and cycling facilities/exercise facilities and neighborhood aesthetics are less likely to develop physical frailty. Current evidence regarding sarcopenia remains limited and inconclusive.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"137 ","pages":"Article 105910"},"PeriodicalIF":3.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the “European health divide”: Functional limitation disparities among older adults in Central and Eastern Europe","authors":"Shane D. Burns ,&nbsp;Liili Abuladze ,&nbsp;Luule Sakkeus","doi":"10.1016/j.archger.2025.105908","DOIUrl":"10.1016/j.archger.2025.105908","url":null,"abstract":"<div><h3>Objectives</h3><div>Countries in Central and Eastern Europe (CEE) generally have worse health outcomes than the rest of Europe, commonly referred to as the “European health divide”. Regional specificities and historical pathways can shape health outcomes later in life, although variance of older adult functional limitation <em>within</em> CEE is understudied.</div></div><div><h3>Methods</h3><div>We used wave 9 (2021–2022) data (<em>n</em> = 18,903) from the Survey of Health, Ageing and Retirement in Europe (SHARE) with mixed effects regression models to analyze difficulty with mobility, near vision, hearing, and episodic memory among those ages 65+ in the Baltic States (Estonia; Latvia; Lithuania), Visegrád Group (Czechia; Hungary; Poland; Slovakia), Former Yugoslavia (Croatia; Slovenia), and the Black Sea (Bulgaria; Romania) while accounting for demographic, socioeconomic, health, and social tie indicators.</div></div><div><h3>Results</h3><div>Age-adjustments showed the highest difficulty rates of: mobility in Romania and Hungary, near vision in Latvia and Bulgaria, hearing in Estonia and Poland, and episodic memory in Poland and Croatia. Compared to the Baltic States, odds of reporting mobility difficulty were greater in the Black Sea but accounted for by socioeconomic factors. Fully adjusted odds of reporting near vision difficulty were lower in Visegrád Group and Former Yugoslavia. Fully adjusted odds of reporting hearing difficulty were lower in Visegrád Group, Former Yugoslavia, and the Black Sea. There were no regional differences in episodic memory.</div></div><div><h3>Discussion</h3><div>Functional limitation disparities, which were largely shaped by socioeconomic factors, varied throughout CEE. These findings highlight the heterogenous health and long-term care needs of older adults throughout CEE.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105908"},"PeriodicalIF":3.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long fever Fever as a long-term risk factor for mortality in persons in assisted living facilities","authors":"Abdullah Y. Ali ,&nbsp;Ahmed Adham R. Elsayed ,&nbsp;William P. Newman ,&nbsp;Marilyn G. Klug ,&nbsp;Marc D. Basson","doi":"10.1016/j.archger.2025.105909","DOIUrl":"10.1016/j.archger.2025.105909","url":null,"abstract":"<div><h3>Background</h3><div>The aging population and increasing use of assisted living facilities necessitate a better understanding of risk factors for adverse outcomes. Fever as a long-term risk factor in elderly populations remains understudied.</div></div><div><h3>Methods</h3><div>We analyzed data from 16,523 veterans in assisted living facilities between 2012–2022, examining the relationship between fever (defined as temperature ≥100.4°F) and mortality at 90-, 365-, and 730-days post-admission. Subjects were categorized by fever timing (none, at intake, or after intake), temperature severity, and percentage of days febrile.</div></div><div><h3>Results</h3><div>Fever at intake and fever after admission were associated with significantly increased mortality compared to no fever (<em>p</em> &lt; .001) at all time points. Higher fever temperatures (&gt;105°F) and a greater percentage of days febrile (&gt;5 %) correlated with worse mortality. Patients with fever at intake and a few percentage of days febrile (&lt;5 %) had an OR of 1.24 (95 % CI 1.01–1.53) for mortality by 1 year compared to patients who did not have a fever. High (&gt;105°F) early fever had an OR of 1.46 (95 % CI 1.20–1.78), and early fever with many days febrile (&gt;5 %) had an OR of 1.53 (95 % CI 1.33–1.75) for mortality at 730 days compared to patients with no fever.</div></div><div><h3>Conclusions</h3><div>Fever in assisted living residents increases mortality risk for up to two years, depending on temperature severity and duration. These findings suggest a \"long fever\" phenomenon, where acute febrile episodes may have lasting consequences. Incorporating fever status into risk stratification may help identify high-risk patients requiring enhanced monitoring and care.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105909"},"PeriodicalIF":3.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incident dementia across neighbourhood material deprivation: Implications for underdiagnosis","authors":"Sanjna Navani ,&nbsp;Isabelle Vedel ,&nbsp;Geneviève Arsenault-Lapierre ,&nbsp;Nadia Sourial ,&nbsp;Amélie Quesnel-Vallée ,&nbsp;Louis Rochette ,&nbsp;Victoria Massamba ,&nbsp;Claire Godard-Sebillotte","doi":"10.1016/j.archger.2025.105905","DOIUrl":"10.1016/j.archger.2025.105905","url":null,"abstract":"<div><h3>Background</h3><div>Evidence consistently demonstrates that lower socioeconomic status (SES) confers greater dementia risk and that it is associated with poorer outcomes including reduced access to care. Furthermore, underdiagnosis is a widespread issue in dementia. However, few studies investigate whether one of the poorer outcomes associated with lower SES is a greater degree of dementia underdiagnosis.</div></div><div><h3>Methods</h3><div>We conducted a province-wide repeated yearly cross-sectional study (2000–17) of community-dwelling people with incident dementia in Quebec. Data were sourced from health administrative data held at the Quebec National Institute of Public Health and SES was assessed through a material deprivation index (a composite measure of the SES of census-based neighbourhoods). Given our near population-level sample, we used a descriptive approach: we described the proportion of incident dementia cases in each of 5 SES categories, from least to most material deprivation.</div></div><div><h3>Results</h3><div>Of the 193,834 community-dwelling people with a new diagnosis of dementia between 2000–17, around 20 % belonged to each material deprivation category on average. Incident cases in the two least deprived categories comprised 18 % each of total incident cases, and 22 % each in the two most deprived categories.</div></div><div><h3>Conclusion</h3><div>Despite global findings of higher dementia incidence in lower SES, we found similar incidence across levels of material deprivation. Considering that recent work indicates that lower SES in Quebec is associated with poorer health outcomes consistent with literature, our discrepant finding of comparable incidence cases in the least and most deprived neighbourhoods indicates that there is likely severe underdiagnosis of dementia in people living in more materially deprived neighbourhoods in Quebec.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105905"},"PeriodicalIF":3.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of two-time zones online training to transform older people's care","authors":"Rafaela. F. da Silva ,&nbsp;Fiona. Ecarnot ,&nbsp;Jane. Barratt ,&nbsp;Joel. Belmin ,&nbsp;Jean-Pierre. Kraehenbuhl ,&nbsp;Jean-Pierre. Michel","doi":"10.1016/j.archger.2025.105896","DOIUrl":"10.1016/j.archger.2025.105896","url":null,"abstract":"<div><div>This paper reports the evaluation by trainees of the innovative online education initiative known as the e-TRIGGER (e-TRaining In Gerontology and Geriatrics) program, which targets healthcare professionals working with older adults in Africa, the Middle East, and Europe (AFMEE course) and in Asia-Oceania (ASIO). The e-TRIGGER programs are implemented under the auspices of the International Association of Gerontology and Geriatrics (IAGG). The first year of teaching of the AFMEE program (May 2023 to April 2024) and the third year of the ASIO program (January to December 2024) were evaluated by the students using a satisfaction survey implemented at the end of the year of teaching. Almost all trainees reported that the course met their personal objectives. A significant majority reported applying acquired knowledge directly (AFMEE, 75 %; ASIO, 78 %) and indirectly (AFMEE, 30 %; ASIO, 42 %) in their daily work. Over half reported improved skills in caring for older adults (AFMEE 65 %, ASIO 52 %). Around one-fifth reported a job or career promotion after course completion (AFMEE 21 %, ASIO 17 %). The evaluation highlights the significant impact and success of the e-TRIGGER program for most alumni. Key challenges of this innovative teaching program include ensuring financial sustainability and addressing specific training needs related to long-term care, dementia management, and technology integration. Future perspectives include expanding the program to Latin America (IAGG e-TRIGGER LATAM) and developing complementary, specialized short courses on specific areas of geriatric medicine and gerontology.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105896"},"PeriodicalIF":3.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different movement velocities during resistance training on bone mineral density in older adults: A systematic review and meta-analysis","authors":"Riccarda A. Quattlaender ,&nbsp;Paul Rothmore ,&nbsp;Mark R. Hutchinson ,&nbsp;Timothy JH. Lathlean","doi":"10.1016/j.archger.2025.105906","DOIUrl":"10.1016/j.archger.2025.105906","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of different movement velocities during progressive resistance training (PRT) on bone mineral density (BMD) in older adults, with an emphasis on program design and training principles.</div></div><div><h3>Methods</h3><div>Seven databases were comprehensively searched to identify studies investigating the effect of PRT at different movement velocities on BMD. The primary outcome was BMD at fracture-relevant sites measured by dual-energy X-ray absorptiometry (DXA). Meta-analysis of within-group changes was conducted using a random-effects model.</div></div><div><h3>Results</h3><div>Of 1830 screened records, 9 studies met the inclusion criteria. No statistical comparison was possible regarding movement velocity. However, the findings suggest benefits of incorporating high-velocity movements. The analysis revealed that moderate-velocity programs frequently failed to prevent bone loss. In terms of program design, significant benefits of variation in PRT programs were observed. Moreover, the interventions demonstrated substantial interindividual variability in efficacy.</div></div><div><h3>Conclusion</h3><div>High-velocity PRT effectively enhanced BMD when overarching training principles were met. Nevertheless, further research is required to confirm the superior efficacy of high-velocity training. Moreover, individualization is essential since responses to programs vary, prompting questions about underlying differences. Considering that osteoporosis involves defective mechanotransduction, factors beyond established confounders may influence the intervention's efficacy.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"136 ","pages":"Article 105906"},"PeriodicalIF":3.5,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}