Archives of gerontology and geriatrics最新文献

{"title":"Dual trajectories of nighttime sleep duration and frailty in relation to cardiovascular disease risk in middle-aged and older Chinese adults: a longitudinal study","authors":"Qingcui Wu ,&nbsp;Junfeng Zhang ,&nbsp;Jianqi Liu,&nbsp;Huijie Huang,&nbsp;Zihao Zhang,&nbsp;Shuoying Yue,&nbsp;Meng Su,&nbsp;Jiageng Chen,&nbsp;Shi Zhao,&nbsp;Jun Ma","doi":"10.1016/j.archger.2026.106149","DOIUrl":"10.1016/j.archger.2026.106149","url":null,"abstract":"<div><h3>Background</h3><div>Little is known about the associations between long-term patterns of sleep and frailty and their impact on cardiovascular disease risk. We aimed to delineate trajectories of nighttime sleep duration and frailty, compare baseline characteristics across trajectory groups, and evaluate their independent and joint associations with cardiovascular disease (CVD) risk.</div></div><div><h3>Methods</h3><div>Trajectories of sleep duration and frailty index (FI) were modeled using three biennial waves (2011–2015) of the China Health and Retirement Longitudinal Study (CHARLS). Group-based and dual trajectory modeling identified distinct patterns. Baseline characteristics across trajectories were examined using multinomial logistic regression. Cox proportional hazards models estimated hazard ratios (HRs) and 95 % confidence intervals (CIs) for CVD events occurring during 2015–2018 follow-up.</div></div><div><h3>Results</h3><div>Among 6972 participants, four sleep trajectories and three frailty trajectories were identified. Compared with the stable-8-hours sleep trajectory, the stable-5-hours group had higher risks of CVD (HR: 1.33, 95 % CI: 1.05–1.68) and heart disease (HR: 1.42, 95 % CI: 1.07–1.88), significant only for women in sex-stratified analyses. Stable pre-frail and frail trajectories were linked to elevated risks of CVD (HR: 1.92, 95 % CI: 1.45–2.55; HR: 3.70, 95 % CI: 2.63–5.21) and heart disease (HR: 2.28, 95 % CI: 1.60–3.24; HR: 4.61, 95 % CI: 3.03–7.00) in both sexes. Dual-trajectory analyses revealed co-development patterns of sleep and frailty, with the highest CVD risk (HR: 3.04, 95 % CI: 1.88–4.91) observed among individuals with both stable pre-frail/frail and stable-5-hours trajectories.</div></div><div><h3>Conclusion</h3><div>Sleep duration and frailty trajectories are interrelated over time and jointly influence CVD risk. Monitoring their long-term patterns may improve the precision of CVD prevention.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106149"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning model for prediction of risk of dementia superimposed on delirium in intensive care patients","authors":"Xinya Li ,&nbsp;Weisheng Chen ,&nbsp;Zhigang Wang ,&nbsp;Lei Wang ,&nbsp;Xi Huai ,&nbsp;Hongtao Cheng ,&nbsp;Yu Wang ,&nbsp;Jun Lyu","doi":"10.1016/j.archger.2026.106161","DOIUrl":"10.1016/j.archger.2026.106161","url":null,"abstract":"<div><h3>Background</h3><div>The objective of this study was to construct a predictive model using multiple machine learning algorithms to predict the risk of dementia superimposed on delirium (DSD) in dementia patients in the ICU.</div></div><div><h3>Methods</h3><div>The data for this study were sourced from the Medical Information Mart for Intensive Care IV database. The dataset was divided into a development set (70%) and a test set (30%). Feature selection was conducted using the Boruta algorithm to identify clinically relevant predictors, followed by model development using logistic regression, decision trees, random forest, XGBoost, glmnet, k-nearest neighbors (KNN), support vector machine (SVM), and neural network (NNET). The performance of the model was evaluated using several performance metrics, including the area under the curve (AUC), accuracy, precision, sensitivity, specificity, and the F-beta score.</div></div><div><h3>Results</h3><div>The findings demonstrated that the XGBoost model showed stable and acceptable discriminative performance, with an AUC of 0.7072 in the development set and 0.7258 in the test set, along with reasonable agreement between predicted and observed risks. The model achieved a balanced classification profile, with satisfactory specificity and sensitivity, and an F-beta score of 0.7594 in the test set. Decision curve analysis indicated that the XGBoost model provided net clinical benefit across a range of decision thresholds.</div></div><div><h3>Conclusions</h3><div>XGBoost-based machine learning models demonstrate moderate discriminative ability for predicting the occurrence of DSD in ICU patients with dementia and may support risk stratification in similar ICU settings, pending further external validation in independent cohorts.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106161"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-dimensional social frailty index for predicting disability and mortality in community-dwelling older adults: JAGES cohort","authors":"Takahiro Hayashi ,&nbsp;Taiji Noguchi ,&nbsp;Ryota Watanabe ,&nbsp;Yuta Kubo ,&nbsp;Taishi Tsuji ,&nbsp;Masashige Saito ,&nbsp;Katsunori Kondo","doi":"10.1016/j.archger.2026.106158","DOIUrl":"10.1016/j.archger.2026.106158","url":null,"abstract":"<div><h3>Background and objectives</h3><div>We explored the association between a constructed multi-dimensional social frailty index and incidence of disability and all-cause mortality among community-dwelling older adults, examining its prognostic validity.</div></div><div><h3>Research design and methods</h3><div>We obtained data from the 2016 Japan Gerontological Evaluation Study (JAGES), surveying community-dwelling individuals aged ≥65 years, not certified as requiring long-term care, at baseline. The analytical sample comprised 73,472 participants (mean age, 73.7 years; 53.4% women) from 18 municipalities across 10 prefectures in Japan. The social frailty index comprised seven items across four domains: general resources (subjective financial conditions), social resources (living arrangements; social networks [visiting friends]), social behavior/activities (social participation; decreased frequency of going out), and basic social needs fulfillment (emotional social support; social cohesion [community attachment]). Incident disability and all-cause mortality were recorded over a mean 3.5-year follow-up. Associations were examined using Cox proportional hazards models adjusted for demographics, health status, and physical, cognitive, and depressive symptoms.</div></div><div><h3>Results</h3><div>Participants were classified as socially non-frail (51.6%), socially pre-frail (39.5%), and socially frail (9.0%). Higher social frailty scores were significantly associated with increased risk of disability and mortality. In the demographics and health status-adjusted model, incident disability hazard ratios were 1.41 for social pre-frailty and 1.77 for social frailty, whereas corresponding mortality hazard ratios were 1.35 and 1.65, respectively (all <em>P</em> &lt; 0.001).</div></div><div><h3>Discussion</h3><div>The multi-dimensional social frailty index demonstrated robust prognostic validity for adverse health outcomes.</div></div><div><h3>Implications</h3><div>Integrating social dimensions into frailty assessments may facilitate early interventions, inform policy development, and improve health maintenance in aging populations.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106158"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of functional exercise on healthy aging in women over 60 years of age: A systematic review and meta-analysis","authors":"Hugo Rodríguez-Otero ,&nbsp;Pablo Hernandez-Lucas ,&nbsp;Juan Lopez-Barreiro ,&nbsp;Raquel Leirós-Rodríguez","doi":"10.1016/j.archger.2026.106129","DOIUrl":"10.1016/j.archger.2026.106129","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthy aging is a major public health priority, particularly for women, who have a longer life expectancy and a high prevalence of conditions associated with frailty, sarcopenia, and loss of functional independence. Therefore, the objective of this systematic review and meta-analysis was to evaluate the effects of functional exercise on physical and psychosocial outcomes in women over 60 years of age.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis was conducted following PRISMA guidelines. Searches were performed in PubMed, Scopus, Web of Science, and Cochrane Library up to September 2025. Only randomized controlled trials involving women aged 60 years and older who participated in functional exercise interventions were included. Methodological quality was assessed with the PEDro scale, and pooled analyses were conducted using standardized mean differences (SMD) with 95% confidence intervals.</div></div><div><h3>Results</h3><div>Seventeen randomized controlled trials with a total of 968 participants met the inclusion criteria. Meta-analyses showed that functional exercise significantly improved physical capacities, including functionality (SMD = 0.81; 95% CI = 0.62 to 0.99), strength (SMD = 0.51; 95% CI = 0.11 to 0.91), and power (SMD = 0.28; 95% CI = 0.10 to 0.46). Additional evidence suggested improvements in psychosocial outcomes and reductions in proinflammatory cytokines, although results were more heterogeneous. The overall methodological quality of the included studies was moderate to high.</div></div><div><h3>Conclusions</h3><div>Functional exercise may be a beneficial strategy to enhance physical and psychosocial capacities in women over 60 years of age. It may also contribute to modulating inflammatory and immunosenescence-related responses; however, the evidence remains limited and should be interpreted with caution. Further high-quality studies are needed to support its integration into healthy aging and preventive care programs.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106129"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty trajectories and risk of incident advanced CKM syndrome: A national cohort analysis","authors":"Haojiang Li ,&nbsp;Qingqing Li ,&nbsp;Ru Sun ,&nbsp;Li Ni ,&nbsp;Feng Wang ,&nbsp;Jia Cheng ,&nbsp;Ling Zhou ,&nbsp;Chunxia Zhao","doi":"10.1016/j.archger.2026.106159","DOIUrl":"10.1016/j.archger.2026.106159","url":null,"abstract":"<div><h3>Background</h3><div>The interplay between frailty dynamics and the newly defined Cardiovascular-Kidney-Metabolic (CKM) syndrome remains poorly understood. We aimed to quantify the association between frailty transitions and the risk of incident advanced CKM syndrome and identify modifiable drivers of frailty progression.</div></div><div><h3>Methods</h3><div>Using data from the China Health and Retirement Longitudinal Study (CHARLS), we analyzed 8159 participants cross-sectionally and 3506 longitudinally over four years. Frailty was assessed using a deficit-accumulation index. The primary outcome was prevalent and incident advanced CKM syndrome (Stages 3–4). We employed multivariable regression models to evaluate associations and a machine learning pipeline to identify key predictors of frailty progression.</div></div><div><h3>Results</h3><div>Baseline frailty showed a robust dose-response relationship with prevalent advanced CKM (OR 1.44 per 0.1-unit FI increase; 95% CI 1.38–1.51). Longitudinally, individuals progressing to a frail state had a 40% increased risk of incident advanced CKM compared to stable non-frail peers (OR 1.40; 95% CI 1.01–1.94). Notably, this risk was sex-specific, observing a significant association in men (OR 2.20; 95% CI 1.33–3.64) but not in women. Machine learning identified life satisfaction, smoking status, and sleep duration as the top predictors of frailty progression.</div></div><div><h3>Conclusions</h3><div>Frailty progression acts as a potent, sex-specific risk amplifier for advanced CKM syndrome. Integrating frailty screening into CKM care and targeting psychosocial well-being—specifically life satisfaction—alongside lifestyle factors may be important strategies to preempt frailty and potentially mitigate cardiovascular-renal-metabolic risks.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106159"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of cardiac ejection fraction and atrial fibrillation on elderly hemodialysis patients","authors":"Da Woon Kim ,&nbsp;Yu Ah Hong ,&nbsp;Sung Joon Shin ,&nbsp;Soon Hyo Kwon ,&nbsp;Sungjin Chung ,&nbsp;Young Youl Hyun ,&nbsp;Byung Chul Yu ,&nbsp;Jae Won Yang ,&nbsp;Won Min Hwang ,&nbsp;Jang-Hee Cho ,&nbsp;Kyung Don Yoo ,&nbsp;In O Sun ,&nbsp;Gang-Jee Ko ,&nbsp;Hyunsuk Kim ,&nbsp;Woo Yeong Park ,&nbsp;Eunjin Bae ,&nbsp;Sang Heon Song","doi":"10.1016/j.archger.2026.106140","DOIUrl":"10.1016/j.archger.2026.106140","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate all-cause mortality in elderly patients starting hemodialysis (HD) according to left ventricular ejection fraction [LVEF] and atrial fibrillation (AF).</div></div><div><h3>Methods</h3><div>We analyzed 1,137 incident HD patients aged ≥70 years from a retrospective multicenter cohort of the Korean Society of Geriatric Nephrology. All-cause mortality was evaluated within the first 6 months and beyond 6 months using a landmark analysis (median follow-up, 3.7 years) according to LVEF and AF status. Sequential Cox proportional hazards models were applied, adjusted for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Patients were classified into four groups according to LVEF (≥50% vs. &lt;50%) and AF status. After full adjustment, neither reduced LVEF nor AF was independently associated with 6-month mortality. Early mortality was mainly associated with older age, lower serum albumin, and impaired mobility. In the 6-month landmark analysis, compared with patients with preserved LVEF and no AF, those with reduced LVEF without AF (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.01–1.65), preserved LVEF with AF (HR 1.35, 95% CI 1.02–1.80), and reduced LVEF with AF (HR 1.69, 95% CI 1.03–2.79) had progressively higher long-term mortality risks.</div></div><div><h3>Conclusions</h3><div>In elderly patients initiating HD, reduced LVEF and AF were independently associated with higher long-term mortality, whereas short-term mortality was predominantly driven by frailty and nutritional status rather than cardiac factors. These findings highlight the importance of time-specific risk stratification and integrated cardiovascular and geriatric management in this population.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106140"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic status, dietary pattern, and frailty in older adults in rural China: A prospective longitudinal study","authors":"Huaqing Liu ,&nbsp;Yuhui Sun ,&nbsp;Xiaoting Hu ,&nbsp;Xi Tian ,&nbsp;Chengchao Zhou","doi":"10.1016/j.archger.2026.106130","DOIUrl":"10.1016/j.archger.2026.106130","url":null,"abstract":"<div><h3>Objective</h3><div>This study explored the association between dietary patterns and frailty, and the mediating role of diet in the socioeconomic status (SES)-frailty relationship among rural Chinese older adults.</div></div><div><h3>Methods</h3><div>Data came from the Shandong Rural Elderly Health Cohort Survey (2019-2022). Longitudinal associations between dietary patterns and frailty were analyzed using generalized estimating equations. Mediation pathways were examined using Hayes’ <em>PROCESS</em> macro to determine how dietary patterns influence the socioeconomic gradient in frailty.</div></div><div><h3>Results</h3><div>Of 1903 participants, 12.3 % developed frailty over 3-year follow-up, with significant differences across education and household income levels (<em>P</em> &lt; 0.001). After adjustment of confounders (age, sex, marital status, education level, occupation, physical activity, smoking status, drinking status, household income, BMI, and chronic diseases), adherence to a milk–bean–egg–fruit dietary pattern was associated with a lower risk of frailty, with OR in Q2, Q3, and Q4 of 0.69 (95 % CI: 0.53‒0.91), 0.62 (95 % CI: 0.47‒0.81), and 0.53 (95 % CI: 0.40‒0.70), respectively, compared with Q1. Notably, this dietary pattern significantly mediated the associations of household income and education level with frailty risk, explaining 28.33 % and 15.58 % of the respective total effects.</div></div><div><h3>Conclusions</h3><div>The milk–bean–egg–fruit dietary pattern exerts a protective effect against frailty and mediates the association between socioeconomic status and frailty risk. The current findings underscore the importance of educational and socioeconomic support initiatives in rural areas as well as promoting healthier dietary habits among older adults through targeted nutritional interventions to reduce frailty risk.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106130"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisation trends for falls and facial fractures in elderly Australian: A national ecological analysis, from 2013–14 to 2022–23","authors":"Parmis Aminian,&nbsp;Max Eton,&nbsp;Marc Tennant,&nbsp;Estie Kruger","doi":"10.1016/j.archger.2026.106147","DOIUrl":"10.1016/j.archger.2026.106147","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated national trends in fall- and facial fracture–related hospitalisations among Australians aged 65 years and over from 2013 to 14 to 2022–23, and examined the association between hospitalisation of specific facial fracture subtypes and fall rates.</div></div><div><h3>Study Design</h3><div>Ecological study using publicly available national hospitalisation data.</div></div><div><h3>Methods</h3><div>The dataset included all hospital admissions with a principal diagnosis of fall or facial fracture. Trends in hospitalisation rates were analysed using linear regression, and Pearson correlation was applied to assess associations between fall and facial fracture rates. Indexed trends and scatterplots were used to visualise temporal and population-level relationships.</div></div><div><h3>Results</h3><div>From 2013–14 to 2022–23, facial fracture hospitalisation rates among Australians aged 65+ increased from 55.7 to 84.4 per 100,000, while fall-related hospitalisations rose from 2891.5 to 3171.8 per 100,000. Although both trends were significant, facial fractures increased disproportionately faster than falls over the decade-long study period overall. Nasal fractures had the highest average rate (40.04 per 100,000) and mandibular fractures the lowest (5.17 per 100,000). Fall-related hospitalisation rates were 9.4 times higher in adults aged 85+ years than in those aged 65–69, while facial fracture rates were 6.6 times higher in the oldest group. Correlation analysis showed a strong positive association between fall-related and overall facial fracture hospitalisation rates across the study period. Reliance on principal diagnosis codes likely underestimated facial fractures.</div></div><div><h3>Conclusions</h3><div>Facial fracture hospitalisations among older Australians increased disproportionately compared with falls, underscoring the need for integrated prevention strategies in this ageing population.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106147"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes and safety of SGLT2 inhibitors in the older population with heart failure: A systematic review and meta-analysis","authors":"Ayan Khalid ,&nbsp;Rahul Balach ,&nbsp;Anas Rasool ,&nbsp;Shaikh Muhammad Daniyal ,&nbsp;Muhammad Taha Nizami ,&nbsp;Isbah Gul ,&nbsp;Ashmat Naqvi ,&nbsp;Gregg C. Fonarow ,&nbsp;Saad Ahmed Waqas","doi":"10.1016/j.archger.2026.106138","DOIUrl":"10.1016/j.archger.2026.106138","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) predominantly affects older adults, yet this group remains underrepresented in sodium–glucose cotransporter-2 inhibitor (SGLT2i) trials. Given their frailty and multimorbidity, clarifying the potential benefit and safety of SGLT2i in older HF patients is essential.</div></div><div><h3>Methods</h3><div>PubMed, ScienceDirect, and Cochrane Central were searched through August 2025 for randomized controlled trials (RCTs) and observational studies comparing SGLT2i with control in patients aged ≥65 years with HF. Hazard ratios (HRs), risk ratios (RRs), and mean differences (MDs) were pooled using random-effects models.</div></div><div><h3>Results</h3><div>Ten studies (4 RCTs, 6 cohorts; <em>n</em> = 20,844) were included. SGLT2i was associated with a lower hazard of all-cause mortality (HR 0.81 [95% CI 0.72–0.90]; <em>p</em> &lt; 0.001), cardiovascular (CV) death (HR 0.83 [0.74–0.94]; <em>p</em> = 0.004), first HF hospitalization (HR 0.73 [0.66–0.80]; <em>p</em> &lt; 0.001), composite CV death or HF hospitalization (HR 0.78 [0.70–0.87]; <em>p</em> &lt; 0.001), and rehospitalization (HR 0.60 [0.53–0.69]; <em>p</em> &lt; 0.001). SGLT2i lowered serious adverse events (RR 0.92 [0.89–0.95]; <em>p</em> &lt; 0.001) and slowed renal function decline (MD 1.86 [1.15–2.58] mL/min/1.73 m² per year; <em>p</em> &lt; 0.001). An increase was observed in genital (RR 3.07 [2.03–4.64]; <em>p</em> &lt; 0.001) and urinary tract infections (RR 1.19 [1.03–1.38]; <em>p</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>In older patients with HF, SGLT2i was associated with lower mortality and HF hospitalizations and with a slower renal decline, while largely maintaining a favorable safety profile. These findings support the consideration of SGLT2i as an important therapeutic option for older adults with HF.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106138"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of childhood conditions and lifestyles on depression trajectories in older adults: a latent growth model approach","authors":"Cindy Xinshan Jia ,&nbsp;Wenjin Wang ,&nbsp;Li Li","doi":"10.1016/j.archger.2026.106154","DOIUrl":"10.1016/j.archger.2026.106154","url":null,"abstract":"<div><h3>Objectives</h3><div>The current study explored how childhood conditions influence the trajectory of depression in older adults, with a focus on the mediating roles of health-related and social lifestyle factors.</div></div><div><h3>Methods</h3><div>Longitudinal data were drawn from the 2018, 2020, and 2022 waves of the China Family Panel Studies. It comprised 2, 878 older adults aged 60 or older. Latent growth modeling was used to assess the effects of childhood conditions on baseline levels and changes in depression over time, as well as the mediating roles of lifestyle.</div></div><div><h3>Results</h3><div>Poor childhood health and lower family status were associated with higher baseline levels of depressive symptoms. Health-promoting and social lifestyle factors, particularly connectedness with children and regular physical activity, were linked to lower initial depression levels, whereas smoking was associated with a faster increase in depressive symptoms over time. In addition, connectedness with children partially mediated the association between childhood health and baseline depression.</div></div><div><h3>Conclusion</h3><div>The findings address the long-term impact of childhood conditions on depression in later life and highlight the protective role of favorable social and health-promoting lifestyles. Suggestions for targeted policies and interventions to support the mental well-being of aging populations were discussed.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"143 ","pages":"Article 106154"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}